Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention

Name: Work Video:
Duration: 3 min 30 s
Abdelhakim Ahmed‐Belkacem; Jean‐François Guichou; Rozenn Brillet; Nazim Ahnou; Eva Hernández; Coralie Pallier; Jean‐Michel Pawlotsky
{'id': 'https://openalex.org/W2123348911', 'doi': 'https://doi.org/10.1093/nar/gku632', 'title': 'Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention', 'display_name': 'Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention', 'publication_year': 2014, 'publication_date': '2014-07-22', 'ids': {'openalex': 'https://openalex.org/W2123348911', 'doi': 'https://doi.org/10.1093/nar/gku632', 'mag': '2123348911', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25053847', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4132742'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gku632', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/42/14/9399/14123762/gku632.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://academic.oup.com/nar/article-pdf/42/14/9399/14123762/gku632.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004527126', 'display_name': 'Abdelhakim Ahmed‐Belkacem', 'orcid': 'https://orcid.org/0000-0001-6489-5091'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I3019246885', 'display_name': 'Centre Hospitalier Universitaire Henri-Mondor', 'ror': 'https://ror.org/04m61mj84', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019246885']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Abdelhakim Ahmed-Belkacem', 'raw_affiliation_strings': ['Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I3019246885']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046891747', 'display_name': 'Jean‐François Guichou', 'orcid': 'https://orcid.org/0000-0002-7699-3235'}, 'institutions': [{'id': 'https://openalex.org/I4210100279', 'display_name': 'Centre de Biologie Structurale', 'ror': 'https://ror.org/0189yvq06', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I4210100279']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-François Guichou', 'raw_affiliation_strings': ['Centre de Biochimie Structurale, Inserm U1054, CNRS UMR5048, Universités Montpellier 1 et 2, 29 rue de Navacelles, 34090 Montpellier, France'], 'affiliations': [{'raw_affiliation_string': 'Centre de Biochimie Structurale, Inserm U1054, CNRS UMR5048, Universités Montpellier 1 et 2, 29 rue de Navacelles, 34090 Montpellier, France', 'institution_ids': ['https://openalex.org/I4210100279', 'https://openalex.org/I154526488', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005410030', 'display_name': 'Rozenn Brillet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I3019246885', 'display_name': 'Centre Hospitalier Universitaire Henri-Mondor', 'ror': 'https://ror.org/04m61mj84', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019246885']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Rozenn Brillet', 'raw_affiliation_strings': ['Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I3019246885']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033619979', 'display_name': 'Nazim Ahnou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I3019246885', 'display_name': 'Centre Hospitalier Universitaire Henri-Mondor', 'ror': 'https://ror.org/04m61mj84', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019246885']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nazim Ahnou', 'raw_affiliation_strings': ['Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I3019246885']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049153047', 'display_name': 'Eva Hernández', 'orcid': 'https://orcid.org/0000-0003-0215-4743'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I3019246885', 'display_name': 'Centre Hospitalier Universitaire Henri-Mondor', 'ror': 'https://ror.org/04m61mj84', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019246885']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Eva Hernandez', 'raw_affiliation_strings': ['Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I3019246885']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105989061', 'display_name': 'Coralie Pallier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3019246885', 'display_name': 'Centre Hospitalier Universitaire Henri-Mondor', 'ror': 'https://ror.org/04m61mj84', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019246885']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210164847', 'display_name': 'Hôpital Paul-Brousse', 'ror': 'https://ror.org/05n7yzd13', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210164847']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Coralie Pallier', 'raw_affiliation_strings': ['Department of Virology, Hôpital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94800 Villejuif, France', 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I3019246885', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Department of Virology, Hôpital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94800 Villejuif, France', 'institution_ids': ['https://openalex.org/I4210164847']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051956323', 'display_name': 'Jean‐Michel Pawlotsky', 'orcid': 'https://orcid.org/0000-0003-0745-7559'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210112943', 'display_name': 'Department of Virology', 'ror': 'https://ror.org/01xx2ne27', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I157536573', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210112943']}, {'id': 'https://openalex.org/I3019246885', 'display_name': 'Centre Hospitalier Universitaire Henri-Mondor', 'ror': 'https://ror.org/04m61mj84', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019246885']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Jean-Michel Pawlotsky', 'raw_affiliation_strings': ['Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'National Reference Center for Viral Hepatitis B, C, and Delta, Department of Virology, Hôpital Henri Mondor, Université Paris-Est, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France'], 'affiliations': [{'raw_affiliation_string': 'Inserm U955, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I3019246885']}, {'raw_affiliation_string': 'National Reference Center for Viral Hepatitis B, C, and Delta, Department of Virology, Hôpital Henri Mondor, Université Paris-Est, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France', 'institution_ids': ['https://openalex.org/I4210112943']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5051956323'], 'corresponding_institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I4210112943', 'https://openalex.org/I3019246885'], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'fwci': 1.917, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.919129, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '42', 'issue': '14', 'first_page': '9399', 'last_page': '9409'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11112', 'display_name': 'Viral Infections and Immunology Research', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.84309113}, {'id': 'https://openalex.org/C2776449523', 'wikidata': 'https://www.wikidata.org/wiki/Q272631', 'display_name': 'RNA polymerase', 'level': 4, 'score': 0.7484381}, {'id': 'https://openalex.org/C41258723', 'wikidata': 'https://www.wikidata.org/wiki/Q2919111', 'display_name': 'RNA-dependent RNA polymerase', 'level': 4, 'score': 0.742785}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.6508067}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5134688}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.48016137}, {'id': 'https://openalex.org/C2776408679', 'wikidata': 'https://www.wikidata.org/wiki/Q708693', 'display_name': 'Hepatitis C virus', 'level': 3, 'score': 0.46180835}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.4417236}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.30315268}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.27881122}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2061865}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19524652}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047309', 'descriptor_name': 'Flavones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012324', 'descriptor_name': 'RNA-Dependent RNA Polymerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017361', 'descriptor_name': 'Viral Nonstructural Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gku632', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/42/14/9399/14123762/gku632.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4132742', 'pdf_url': 'https://europepmc.org/articles/pmc4132742?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132742', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25053847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gku632', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/42/14/9399/14123762/gku632.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.73, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W119403464', 'https://openalex.org/W130223727', 'https://openalex.org/W1484684532', 'https://openalex.org/W149042840', 'https://openalex.org/W1932632320', 'https://openalex.org/W1965962980', 'https://openalex.org/W1987087121', 'https://openalex.org/W1991612900', 'https://openalex.org/W1997809789', 'https://openalex.org/W2027166401', 'https://openalex.org/W2029250802', 'https://openalex.org/W2038463540', 'https://openalex.org/W2045378360', 'https://openalex.org/W2053240007', 'https://openalex.org/W2067108917', 'https://openalex.org/W2068345565', 'https://openalex.org/W2074316595', 'https://openalex.org/W2082953408', 'https://openalex.org/W2083100985', 'https://openalex.org/W2090128149', 'https://openalex.org/W2097641909', 'https://openalex.org/W2108921801', 'https://openalex.org/W2112831402', 'https://openalex.org/W2114999861', 'https://openalex.org/W2121238034', 'https://openalex.org/W2150733875', 'https://openalex.org/W2151898297', 'https://openalex.org/W2177096160', 'https://openalex.org/W2413797402', 'https://openalex.org/W4205254622', 'https://openalex.org/W4210309881', 'https://openalex.org/W4230210080'], 'related_works': ['https://openalex.org/W4210961822', 'https://openalex.org/W2970236921', 'https://openalex.org/W2388834768', 'https://openalex.org/W2228678012', 'https://openalex.org/W2176417755', 'https://openalex.org/W2048863389', 'https://openalex.org/W2009502018', 'https://openalex.org/W1997573290', 'https://openalex.org/W1974233081', 'https://openalex.org/W1971212384'], 'abstract_inverted_index': {'The': [0, 16], 'hepatitis': [1], 'C': [2], 'virus': [3], '(HCV)': [4], 'RNA-dependent': [5], 'RNA': [6, 63, 91, 135, 173], 'polymerase': [7], '(RdRp)': [8], 'is': [9], 'a': [10, 69, 106, 123, 140, 148], 'key': [11], 'target': [12], 'for': [13, 126, 162], 'antiviral': [14, 72, 101, 160], 'intervention.': [15], 'goal': [17], 'of': [18, 50, 62, 78, 89, 98, 129, 134], 'this': [19], 'study': [20], 'was': [21, 55, 103], 'to': [22, 57, 65, 109, 137, 151, 158, 179], 'identify': [23], 'the': [24, 29, 42, 46, 66, 79, 87, 90, 138, 156], 'binding': [25, 64, 84, 136, 174], 'site': [26, 85], 'and': [27, 115, 147, 164], 'unravel': [28], 'molecular': [30], 'mechanism': [31, 102, 125, 141], 'by': [32], 'which': [33], 'natural': [34], 'flavonoids': [35], 'efficiently': [36], 'inhibit': [37, 58], 'HCV': [38, 51, 130, 163], 'RdRp.': [39], 'Screening': [40], 'identified': [41, 82, 122], 'flavonol': [43], 'quercetagetin': [44], 'as': [45], 'most': [47], 'potent': [48], 'inhibitor': [49], 'RdRp': [52, 59, 131, 170], 'activity.': [53], 'Quercetagetin': [54], 'found': [56], 'through': [60, 132], 'inhibition': [61, 128, 133], 'viral': [67, 187], 'polymerase,': [68], 'yet': [70], 'unknown': [71], 'mechanism.': [73], 'X-ray': [74], 'crystallographic': [75], 'structure': [76], 'analysis': [77], 'RdRp-quercetagetin': [80], 'complex': [81], "quercetagetin's": [83], 'at': [86], 'entrance': [88], 'template': [92], 'tunnel,': [93], 'confirming': [94], 'its': [95], 'original': [96], 'mode': [97], 'action.': [99], 'This': [100], 'associated': [104, 142], 'with': [105, 143], 'high': [107, 149], 'barrier': [108, 150], 'resistance': [110], 'in': [111, 182], 'both': [112], 'site-directed': [113], 'mutagenesis': [114], 'long-term': [116], 'selection': [117], 'experiments.': [118], 'In': [119], 'conclusion,': [120], 'we': [121], 'new': [124, 159], 'non-nucleoside': [127], 'enzyme,': [139], 'broad': [144], 'genotypic': [145], 'activity': [146], 'resistance.': [152], 'Our': [153], 'results': [154], 'open': [155], 'way': [157], 'approaches': [161], 'other': [165], 'viruses': [166], 'that': [167, 176], 'use': [168], 'an': [169], 'based': [171], 'on': [172], 'inhibition,': [175], 'could': [177], 'prove': [178], 'be': [180], 'useful': [181], 'human,': [183], 'animal': [184], 'or': [185], 'plant': [186], 'infections.': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2123348911', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}], 'updated_date': '2024-12-13T19:50:48.612143', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
