Publication Information

{'id': 'https://openalex.org/W2123276946', 'doi': 'https://doi.org/10.1111/epi.12043', 'title': 'Extended‐release antiepileptic drugs: A comparison of pharmacokinetic parameters relative to original immediate‐release formulations', 'display_name': 'Extended‐release antiepileptic drugs: A comparison of pharmacokinetic parameters relative to original immediate‐release formulations', 'publication_year': 2012, 'publication_date': '2012-11-28', 'ids': {'openalex': 'https://openalex.org/W2123276946', 'doi': 'https://doi.org/10.1111/epi.12043', 'mag': '2123276946', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23190215'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/epi.12043', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.12043', 'source': {'id': 'https://openalex.org/S203153751', 'display_name': 'Epilepsia', 'issn_l': '0013-9580', 'issn': ['0013-9580', '1528-1157', '1528-1167'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.12043', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008904502', 'display_name': 'Ilo E. Leppik', 'orcid': 'https://orcid.org/0000-0001-7825-9299'}, 'institutions': [{'id': 'https://openalex.org/I4210122781', 'display_name': 'Minnesota Epilepsy Group', 'ror': 'https://ror.org/02qnmmb02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122781']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ilo E. Leppik', 'raw_affiliation_strings': ['MINCEP Epilepsy Care, Minneapolis, Minnesota 55414, USA.'], 'affiliations': [{'raw_affiliation_string': 'MINCEP Epilepsy Care, Minneapolis, Minnesota 55414, USA.', 'institution_ids': ['https://openalex.org/I4210122781']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024595596', 'display_name': 'Collin A. Hovinga', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Collin A. Hovinga', 'raw_affiliation_strings': ['College of Pharmacy'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3950, 'currency': 'USD', 'value_usd': 3950, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.932, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 55, 'citation_normalized_percentile': {'value': 0.752641, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '54', 'issue': '1', 'first_page': '28', 'last_page': '35'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10094', 'display_name': 'Epilepsy and Seizures', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10094', 'display_name': 'Epilepsy and Seizures', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Prenatal Exposure to Antiepileptic Drugs', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/oxcarbazepine', 'display_name': 'Oxcarbazepine', 'score': 0.88964}, {'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.7627003}, {'id': 'https://openalex.org/keywords/bioequivalence', 'display_name': 'Bioequivalence', 'score': 0.73825574}, {'id': 'https://openalex.org/keywords/levetiracetam', 'display_name': 'Levetiracetam', 'score': 0.69423383}, {'id': 'https://openalex.org/keywords/antiepileptic-drugs', 'display_name': 'Antiepileptic Drugs', 'score': 0.596146}, {'id': 'https://openalex.org/keywords/drug-efflux-pumps', 'display_name': 'Drug Efflux Pumps', 'score': 0.575751}, {'id': 'https://openalex.org/keywords/immediate-release', 'display_name': 'Immediate release', 'score': 0.46127674}], 'concepts': [{'id': 'https://openalex.org/C2781176495', 'wikidata': 'https://www.wikidata.org/wiki/Q176301', 'display_name': 'Oxcarbazepine', 'level': 4, 'score': 0.88964}, {'id': 'https://openalex.org/C2779253243', 'wikidata': 'https://www.wikidata.org/wiki/Q410412', 'display_name': 'Carbamazepine', 'level': 3, 'score': 0.80189675}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.7627003}, {'id': 'https://openalex.org/C2778802184', 'wikidata': 'https://www.wikidata.org/wiki/Q410346', 'display_name': 'Lamotrigine', 'level': 3, 'score': 0.7447381}, {'id': 'https://openalex.org/C42404028', 'wikidata': 'https://www.wikidata.org/wiki/Q864940', 'display_name': 'Bioequivalence', 'level': 3, 'score': 0.73825574}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.69678587}, {'id': 'https://openalex.org/C2777332695', 'wikidata': 'https://www.wikidata.org/wiki/Q417227', 'display_name': 'Levetiracetam', 'level': 3, 'score': 0.69423383}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.6549206}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6392611}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.53251964}, {'id': 'https://openalex.org/C2778337148', 'wikidata': 'https://www.wikidata.org/wiki/Q410400', 'display_name': 'Phenytoin', 'level': 3, 'score': 0.46394277}, {'id': 'https://openalex.org/C3019981671', 'wikidata': 'https://www.wikidata.org/wiki/Q5165929', 'display_name': 'Immediate release', 'level': 2, 'score': 0.46127674}, {'id': 'https://openalex.org/C2775858608', 'wikidata': 'https://www.wikidata.org/wiki/Q576618', 'display_name': 'Anticonvulsant', 'level': 3, 'score': 0.43797845}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.3808363}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.31606677}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000927', 'descriptor_name': 'Anticonvulsants', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002220', 'descriptor_name': 'Carbamazepine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002220', 'descriptor_name': 'Carbamazepine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002220', 'descriptor_name': 'Carbamazepine', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D002220', 'descriptor_name': 'Carbamazepine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D003692', 'descriptor_name': 'Delayed-Action Preparations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004361', 'descriptor_name': 'Drug Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004827', 'descriptor_name': 'Epilepsy', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D014635', 'descriptor_name': 'Valproic Acid', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/epi.12043', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.12043', 'source': {'id': 'https://openalex.org/S203153751', 'display_name': 'Epilepsia', 'issn_l': '0013-9580', 'issn': ['0013-9580', '1528-1157', '1528-1167'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23190215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/epi.12043', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.12043', 'source': {'id': 'https://openalex.org/S203153751', 'display_name': 'Epilepsia', 'issn_l': '0013-9580', 'issn': ['0013-9580', '1528-1157', '1528-1167'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1487549987', 'https://openalex.org/W1967331310', 'https://openalex.org/W1967986271', 'https://openalex.org/W1969836710', 'https://openalex.org/W1974870612', 'https://openalex.org/W1975444170', 'https://openalex.org/W1976952384', 'https://openalex.org/W1982112616', 'https://openalex.org/W1987708379', 'https://openalex.org/W2003114406', 'https://openalex.org/W2004766765', 'https://openalex.org/W2005854469', 'https://openalex.org/W2007754754', 'https://openalex.org/W2014730115', 'https://openalex.org/W2016854448', 'https://openalex.org/W2025797846', 'https://openalex.org/W2027045140', 'https://openalex.org/W2028410743', 'https://openalex.org/W2029173624', 'https://openalex.org/W2035104898', 'https://openalex.org/W2035212715', 'https://openalex.org/W2040804201', 'https://openalex.org/W2043818223', 'https://openalex.org/W2048355456', 'https://openalex.org/W2053816089', 'https://openalex.org/W2053969120', 'https://openalex.org/W2057438779', 'https://openalex.org/W2070435801', 'https://openalex.org/W2082606768', 'https://openalex.org/W2088730720', 'https://openalex.org/W2099081329', 'https://openalex.org/W2122481217', 'https://openalex.org/W2132588848', 'https://openalex.org/W2134537454', 'https://openalex.org/W2146123878', 'https://openalex.org/W2146750707', 'https://openalex.org/W2146791878', 'https://openalex.org/W2191300343', 'https://openalex.org/W4240161274', 'https://openalex.org/W4248891925'], 'related_works': ['https://openalex.org/W4248731226', 'https://openalex.org/W2808187625', 'https://openalex.org/W2393802065', 'https://openalex.org/W2378326032', 'https://openalex.org/W2328907297', 'https://openalex.org/W2080388147', 'https://openalex.org/W2057617584', 'https://openalex.org/W2047168413', 'https://openalex.org/W2025044144', 'https://openalex.org/W1974806456'], 'abstract_inverted_index': {'Summary': [0], 'Many': [1], 'antiepileptic': [2], 'drugs': [3], '(AEDs)': [4], 'have': [5, 43, 72, 138, 158], 'short': [6], 'half‐lives': [7], 'with': [8, 95, 171], 'large': [9], 'fluctuations': [10], 'in': [11, 79, 177], 'peak‐to‐trough': [12], 'plasma': [13, 81], 'concentrations.': [14], 'Consequences': [15], 'of': [16, 40, 124, 205], 'these': [17, 36, 41], 'pharmacokinetic': [18], '(PK)': [19], 'properties': [20], 'may': [21, 65, 104, 144, 146, 197], 'include': [22], 'adverse': [23], 'events': [24], '(AEs)': [25], 'and': [26, 113, 126, 136, 194, 202], 'breakthrough': [27], 'seizures,': [28], 'potentially': [29], 'leading': [30], 'to': [31, 75, 91, 106, 150, 190], 'poor': [32], 'adherence.': [33, 68], 'To': [34], 'address': [35], 'challenges,': [37], 'newer': [38], 'formulations': [39, 71, 128, 143, 157], 'AEDs': [42], 'been': [44], 'developed': [45], 'using': [46], 'unique': [47], 'extended‐release': [48], '(ER)': [49], 'technologies.': [50], 'These': [51], 'technologies': [52], 'extend': [53], 'the': [54, 73, 77, 172, 186, 191, 199], 'dosing': [55, 59], 'interval': [56], 'such': [57], 'that': [58, 88, 140], 'frequency': [60], 'can': [61], 'be': [62, 148], 'minimized,': [63], 'which': [64], 'improve': [66, 185], 'patient': [67], 'Available': [69], 'ER': [70, 127, 142, 156, 183, 207], 'potential': [74], 'minimize': [76], 'spikes': [78], 'maximum': [80], 'concentrations': [82], '(C': [83], 'max': [84, 164], ')': [85, 169], 'at': [86], 'steady‐state': [87], 'often': [89], 'contribute': [90], 'AEs': [92], 'during': [93], 'treatment': [94], 'immediate‐release': [96], '(IR)': [97], 'products.': [98], 'In': [99], 'so': [100], 'doing,': [101], 'tolerability': [102], 'advantages': [103], 'lead': [105], 'increased': [107], 'AED': [108], 'effectiveness': [109], 'by': [110], 'improving': [111], 'adherence': [112, 203], 'allowing': [114], 'higher': [115], 'doses': [116], 'if': [117], 'clinically': [118], 'indicated.': [119], 'Direct': [120], 'PK': [121, 188, 195], 'comparison': [122], 'studies': [123], 'IR': [125, 152, 173], '(e.g.,': [129], 'carbamazepine,': [130], 'divalproate': [131], 'sodium,': [132], 'lamotrigine,': [133], 'oxcarbazepine,': [134], 'levetiracetam,': [135], 'phenytoin)': [137], 'found': [139], 'dose‐normalized': [141], 'or': [145], 'not': [147], 'bioequivalent': [149], 'their': [151], 'counterparts,': [153], 'but': [154], 'most': [155], 'a': [159], 'lower': [160], 'fluctuation': [161], 'index': [162], '([C': [163], '–C': [165], 'min': [166], ']/C': [167], 'avg': [168], 'compared': [170], 'versions.': [174], 'This': [175], 'results': [176], 'flatter': [178], 'concentration‐time': [179], 'plots.': [180], 'Not': [181], 'all': [182], 'preparations': [184], 'various': [187, 206], 'parameters': [189], 'same': [192], 'extent,': [193], 'nuances': [196], 'impact': [198], 'effectiveness,': [200], 'tolerability,': [201], 'rates': [204], 'formulations.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2123276946', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2024-09-23T17:10:57.675455', 'created_date': '2016-06-24'}