Publication Information

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'well': [16, 132, 289, 405, 567, 1529, 1991, 2969, 3307], 'to': [18, 172, 291, 445, 880, 1680, 1691, 1715, 1733, 1818, 1888, 1924, 2096, 2116, 2182, 2333, 2474, 2614, 2667, 2731, 2911, 2922, 3112, 3216, 3354, 3382, 3413, 3480, 3535, 3620, 3634, 3718, 3730, 3830], 'provide': [19, 253, 292, 526], 'novel': [20, 82, 293, 355, 1987, 2126, 2179], 'targets': [21, 269, 294, 542, 1612, 1995, 2173], 'drug': [23, 296], 'discovery': [24, 263, 297, 536], 'therapeutic': [26, 271, 299, 544, 1436, 1578, 1657, 1997, 2175], 'intervention.': [27, 272, 300, 545], 'Proteomics-based': [28, 301], 'analysis': [29, 302, 2760, 3064, 3072, 3361, 3465], 'traditional': [31, 304], 'sources': [32, 305, 2098], 'biomarkers,': [34, 88, 307, 361, 2133], 'such': [35, 308, 954], 'serum,': [37, 310], 'plasma,': [38, 311], 'or': [39, 169, 312, 442, 1823, 2235, 2948, 3080, 3225, 3468], 'tissue': [40, 313, 753, 1825, 2196, 2499, 3979], 'lyzates,': [41, 314], 'has': [42, 315, 1870], 'resulted': [43, 316], 'in': [44, 66, 120, 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1142, 1168, 1190, 1241, 1330, 1384, 1410, 1432, 1454, 1519, 1574, 1600, 1758, 1792, 1829, 1860, 1890, 1930, 1968, 2000, 2078, 2249, 2316, 2335], 'microenvironment.': [99, 187, 372, 460, 1704], 'We': [100, 373, 3375], 'collected': [101, 374, 2457, 2557], 'TIFs': [102, 375, 2551, 3580], 'from': [103, 376, 1826, 1893, 2009, 2458, 2612, 2819, 2839, 2975, 3026, 3115, 3209, 3222, 3226, 3293, 3427, 3523, 3596, 3632, 3905, 3976], 'small': [104, 377, 2504, 3642, 3663, 3698], 'pieces': [105, 378, 2505, 2836, 2852, 2978], 'freshly': [107, 380], 'dissected': [108, 381], 'invasive': [109, 382, 2145, 2248, 2355], 'carcinomas': [111, 384, 2147], 'analyzed': [113, 386, 1873, 2931, 3205], 'them': [114, 387], 'by': [115, 134, 166, 175, 388, 407, 439, 448, 577, 999, 1695, 1749, 1874, 1918, 2210, 2390, 2769, 2824, 2876, 2905, 2914, 2955, 3073, 3096, 3175, 3191, 3268, 3488, 3859, 3925, 4010, 4086], 'two-dimensional': [116, 389, 665, 2631, 2678, 2695, 2799, 3741], 'polyacrylamide': [117, 390, 666, 2679, 2894], 'gel': [118, 391, 667, 2696, 2800, 2835, 2977, 3638, 3742], 'electrophoresis': [119, 392, 2632, 2676, 2680, 2697, 2707, 2801, 3743], 'combination': [121, 394], 'with': [122, 395, 1359, 1757, 1828, 2200, 2579, 2606, 2757, 2775, 2845, 2853, 2861, 2979, 3029, 3039, 3098, 3109, 3130, 3144, 3228, 3345, 3409, 3436, 3567, 3605, 3763, 3843, 4080], 'matrix-assisted': [123, 396, 698, 3008], 'laser': [124, 397, 699, 1876, 3009, 3161], 'desorption/ionization': [125, 398, 700], 'time-of-flight': [126, 399], 'mass': [127, 400, 2758, 3127, 3170, 3180, 3273, 3286, 3359, 3425, 3514], 'spectrometry,': [128, 401], 'Western': [129, 402], 'immunoblotting,': [130, 403], 'cytokine-specific': [135, 408], 'antibody': [136, 409, 2656, 3629], 'arrays.': [137, 410], 'This': [138, 411, 1801], 'approach': [139, 412, 2191], 'provided': [140, 413, 3924], 'first': [143, 416, 2094, 2154, 2733, 3241], 'time': [144, 417, 613, 2540], 'snapshot': [146, 419], 'protein': [149, 211, 221, 237, 422, 484, 494, 510, 1328, 1736, 1881, 2608, 2803, 3211, 3266, 3284, 3314, 3343, 3389, 3512, 3558, 3639, 3745], 'components': [150, 423], 'TIF,': [153, 426, 653], 'which': [154, 427, 639, 877, 1744, 3457], 'show': [156, 429], 'consists': [157, 430], 'more': [159, 267, 432, 540, 1993, 2227], 'than': [160, 433, 2228, 3348], 'one': [161, 434, 3337, 3412], 'thousand': [162, 435], 'proteins—either': [163, 436], 'secreted,': [164, 437], 'shed': [165, 438], 'membrane': [167, 440], 'vesicles,': [168, 441], 'externalized': [170, 443], 'due': [171, 444], 'cell': [173, 180, 205, 446, 453, 478, 580, 756, 841, 938, 1698, 3882], 'death—produced': [174, 447], 'complex': [177, 450, 1546], 'network': [178, 451, 1549], 'types': [181, 454, 842, 1699], 'make': [183, 456], 'up': [184, 457, 2910], 'So': [188, 461, 897], 'far,': [189, 462, 898], 'identified': [192, 465, 1803, 3487], '267': [193, 466], 'primary': [194, 467, 2201, 4083], 'translation': [195, 468], 'products': [196, 469], 'including,': [197, 470], 'but': [198, 471, 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[251, 524, 1676, 2092], 'should': [252, 525], 'potentially': [257, 530, 2128], 'rich': [258, 531], 'resource': [259, 532], 'diagnostic': [261, 534, 1988, 2170], 'biomarker': [262, 535], 'identifying': [266, 539, 1986], 'selective': [268, 541, 1994], 'Today': [546], 'there': [547], 'is': [548, 556, 1677, 2093], 'evidence': [549], 'indicating': [550], 'growth': [553, 682, 1181, 1187, 1193, 1210, 1215, 1249, 1373, 1381, 1401, 1426, 1445, 1480, 1485, 1511, 1568, 1951, 1955], 'progression': [555, 940, 1030], 'dependent': [557], 'on': [558, 569, 885, 1362, 1619, 2472, 2988, 3034, 3083, 3164, 3282, 3510, 3554, 3983], 'malignant': [560, 1172], 'cells': [565, 626, 726, 748, 849, 853, 856, 864, 1077, 1560, 3880, 3886], 'multidirectional': [571], 'interactions': [572, 599, 1458, 1551], 'local': [574, 592], 'factors': [575, 628, 1382, 1402], 'produced': [576], 'all': [578, 875, 1696, 3185, 3398, 3454], 'types—tumor,': [581], 'stroma,': [582, 638], 'endothelial': [583, 848, 1954], 'cells,': [584, 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1002, 3041], '(ECM)': [645], '1The': [646], 'abbreviations': [647], 'used': [648, 2552, 3238, 3377], 'are:': [649], 'ECM,': [650], 'matrix;': [652], 'fluid;': [656, 660, 705, 709], 'NAF,': [657], 'nipple': [658, 1740, 1784, 1852, 1914], 'aspirate': [659, 1741, 1785, 1853, 1915], 'IHC,': [661], 'immunochemistry;': [662], '2D': [663, 3637, 3723], 'PAGE,': [664, 3724], 'electrophoresis;': [668, 676], 'IEF,': [669], 'isoelectric': [670, 2669], 'focusing;': [671], 'NEPHGE,': [672], 'nonequilibrium': [673, 2673, 2704], 'pH': [674, 2674, 2705, 3770], 'gradient': [675, 2675, 2706], 'MMP,': [677], 'metalloproteinase;': [679], 'EGF,': [680], 'epidermal': [681, 1248], 'factor;': [683], 'PBS,': [684], 'phosphate-buffered': [685], 'saline;': [686], 'TFA,': [687], 'trifluoroacetic': [688, 2907], 'acid;': [689], 'SN,': [690, 2960], 'supernatant;': [691], 'ACN,': [692], 'acetonitrile;': [693], 'PSD,': [694], 'post-source': [695, 3471], 'decay;': [696], 'MALDI-TOF,': [697], 'time-of-flight;': [701], 'MIF,': [702], 'metastasis': [703, 759], 'NIF,': [706], 'nonmalignant': [707], 'FIF,': [710], 'fat': [711], 'fluid.': [713], 'cytokines': [716, 3577, 3616], 'modify': [718], 'biology': [720, 1555, 2017], '(1Leek': [727], 'R.D.': [728, 1778, 1846], 'Harris': [729], 'A.L.': [730], 'Tumor-associated': [731], 'macrophages': [732, 3876], 'cancer..J.': [735], 'Mammary': [736, 1265], 'Gland': [737, 1266], 'Biol.': [738, 802, 1267, 1289, 2635], 'Neoplasia.': [739, 1268], '2002;': [740, 803, 1117, 1301, 1524, 1622, 1641], '7:': [741, 1665], '177-189Google': [742], 'Scholar).': [743, 1667, 1800, 1868, 1936, 2086, 2324, 2644, 2721, 2787, 2814, 2900, 3022, 3713, 3756], 'In': [744, 1979, 2926, 2936, 3453], 'addition,': [745], 'modified': [746, 3302], 'stroma': [747], 'proteases': [750], 'facilitate': [752], 'destruction,': [754], 'migration,': [757], '(2Liotta': [760], 'L.A.': [761, 1297, 1907], 'Kohn': [762], 'E.C.': [763], 'tumour-host': [768], 'interface..Nature.': [769], '2001;': [770, 1151, 1176, 1225, 1290, 1495, 1933, 1972], '411:': [771], '375-379Google': [772], 'Scholar,': [773, 806, 819, 986, 1037, 1120, 1204, 1228, 1293, 1305, 1341, 1390, 1418, 1474, 1498, 1585, 1608, 1625, 1644, 3689], '5Ahmad': [774], 'S.A.': [775], 'Jung': [776], 'Y.D.': [777], 'Liu': [778], 'W.': [779, 1587], 'Reinmuth': [780], 'N.': [781, 972, 1253, 2029, 2058, 2267, 2296], 'Parikh': [782], 'A.': [783, 968, 1041, 1610, 1631, 2048, 2286, 2881], 'Stoeltzing': [784], 'O.': [785, 2885], 'Fan': [786], 'F.': [787, 1160, 1255], 'Ellis': [788], 'L.M.': [789], 'role': [791, 1027, 1508], 'intracellular': [796], 'cross-talk': [797], 'angiogenesis..Semin': [800], 'Cancer': [801, 811, 981, 1007, 1084, 1174, 1199, 1223, 1469, 1493, 1603, 1794, 1862, 2215, 2478], '12:': [804], '105-112Google': [805], '6Quaranta': [807], 'V.': [808, 1039], 'Giannelli': [809], 'G.': [810, 1157], 'invasion:': [812], 'watch': [813], 'your': [814], 'neighbourhood!.Tumori.': [815], '2003;': [816, 832, 947, 1034, 1086, 1244, 1338, 1368, 1415, 1440, 1471, 1582, 1664, 1797, 1865, 2083, 2321, 3019], '89:': [817], '343-348Google': [818], '10Bogenrieder': [820], 'T.': [821, 1126, 1903, 2027, 2056, 2265, 2294], 'Herlyn': [822], 'M.': [823, 1055, 1130, 1132, 1134, 1185, 1317, 1589, 1901, 1962, 2031, 2050, 2064, 2269, 2288, 2302, 2883, 2887, 3001], 'Axis': [824], 'evil:': [826], 'Molecular': [827, 1611], 'mechanisms': [828], 'metastasis..Oncogene.': [831], '22:': [833, 1441, 1583], '6524-6536Google': [834], 'Scholar': [835, 1975], 'Other': [839, 1937], 'non-neoplastic': [840], 'include': [847, 915, 1942], 'their': [851, 1617], '(pericytes),': [854], '(neutrophils,': [857], 'macrophages,': [858], 'eosinophils,': [859], 'mast': [861, 3879], 'cells),': [862, 867], '(lymphocytes,': [865], 'dendritic': [866], 'smooth': [868], 'muscle': [869], 'myoepithelial': [871], 'adipocytes,': [874], 'believed': [879], 'profound': [883], 'influence': [884], 'biological': [887, 1147], '(1,': [892], '2': [893, 2234, 2572], 'been': [902, 1731, 1816, 1872, 1884], 'implicated': [903], 'regulation': [906, 936], 'ecosystem': [910], 'cancer:': [913, 1143, 1191, 1433, 1575], 'estrogen': [917, 1232, 1592, 2239, 2376, 2417, 2443], 'progesterone': [919, 2241, 2378, 2419, 2446], 'receptors': [920], '(11Doisneau-Sixou': [921], 'S.F.': [922], 'Sergio': [923], 'C.M.': [924], 'Carroll': [925], 'J.S.': [926, 1307, 3264], 'Hui': [927], 'R.': [928, 3933, 3939], 'Musgrove': [929], 'E.A.': [930], 'Sutherland': [931], 'R.L.': [932, 1768, 1836], 'Estrogen': [933], 'antiestrogen': [935], 'cycle': [939], 'cells..Endocr.': [944], 'Relat.': [945], 'Cancer.': [946, 1116], '10:': [948], '179-186Google': [949], 'Scholar),': [950, 1012, 1089, 1154, 1179, 1247, 1272, 1371, 1443, 1527, 3279], 'metalloproteinases': [952], '(MMPs)': [953], 'collagenases,': [957], 'gelatinases,': [958], 'stromelysins,': [959], 'membrane-type': [961], 'MMPs': [962, 3890], '(12Duffy': [963], 'M.J.': [964, 992], 'Maguire': [965], 'T.M.': [966], 'Hill': [967], 'McDermott': [969], 'E.': [970, 1315, 2033, 2271], "O'Higgins": [971], 'Metalloproteinases:': [973], 'Role': [974], 'carcinogenesis,': [977], 'invasion': [978], 'metastasis..Breast': [980], 'Res.': [982, 1008, 1085, 1175, 1200, 1224, 1414, 1470, 1494, 1604, 1795, 1863], '2000;': [983, 1201, 2811, 3753], '2:': [984, 1202, 1270, 1291, 2084, 2322], '252-257Google': [985], '13Fata': [987], 'J.E.': [988, 2019, 2257, 2687, 2764, 2795, 3661, 3693, 3737], 'Werb': [989], 'Z.': [990], 'Bissell': [991], 'Regulation': [993], 'mammary': [995, 1219, 1263, 1467, 1489], 'gland': [996, 1220, 1490], 'branching': [997], 'morphogenesis': [998], 'its': [1004], 'remodeling': [1005], 'enzymes..Breast': [1006], '2004;': [1009, 1605], '6:': [1010, 1606], '1-11Google': [1011], 'urokinase-type': [1013, 1060], 'plasminogen': [1014, 1022, 1061], 'activator': [1015, 1023], 'receptor': [1016, 1071, 1233, 1351, 1428, 1570, 1593, 2242, 2379], '(14Choong': [1017], 'P.F.': [1018], 'Nadesapillai': [1019], 'A.P.': [1020], 'Urokinase': [1021], 'system:': [1024, 1063], 'multifunctional': [1026], 'metastasis..Clin.': [1032], 'Orthop.': [1033], '415:': [1035], 'S46-S58Google': [1036], '15Magdolen': [1038], 'Kruger': [1040], 'Sato': [1042], 'S.': [1043, 1047, 1100, 1124, 2689], 'Nagel': [1044], 'J.': [1045, 1098, 1115, 1295, 1313, 1521, 2040, 2042, 2044, 2060, 2278, 2280, 2282, 2298, 2997], 'Sperl': [1046], 'Reuning': [1048], 'U.': [1049, 1053], 'Rettenberger': [1050], 'P.': [1051, 1398, 2021, 2036, 2038, 2052, 2259, 2274, 2276, 2290, 2691, 2797, 3691, 3739], 'Magdolen': [1052], 'Schmitt': [1054], 'Inhibition': [1056], 'tumor-associated': [1059], 'activation': [1062], 'Effects': [1064], 'high-level': [1066], 'synthesis': [1067], 'soluble': [1069], 'urokinase': [1070], 'ovarian': [1073], 'vitro': [1079], 'vivo..Recent': [1082], 'Results': [1083], '162:': [1087], '43-63Google': [1088], 'intercellular': [1090], 'adhesion': [1091, 1106], 'molecule-1': [1092], "(16O'Hanlon": [1093], 'D.M.': [1094, 3262], 'Fitzsimons': [1095], 'H.': [1096, 2066, 2304], 'Lynch': [1097], 'Tormey': [1099], 'Malone': [1101], 'C.': [1102, 1136, 1905, 2046, 2284], 'Given': [1103], 'H.F.': [1104], 'Soluble': [1105, 1139], 'molecules': [1107], '(E-selectin,': [1108], 'ICAM-1': [1109, 1140], 'VCAM-1)': [1111], 'carcinoma..Eur.': [1114], '38:': [1118], '2252-2257Google': [1119], '17Kostler': [1121], 'W.J.': [1122], 'Tomek': [1123], 'Brodowicz': [1125], 'Budinsky': [1127], 'A.C.': [1128, 1646], 'Flamm': [1129], 'Hejna': [1131], 'Krainer': [1133], 'Wiltschke': [1135], 'Zielinski': [1137], 'C.C.': [1138, 1766, 1834], 'significance': [1145], 'implications..Cancer': [1148], 'Immunol.': [1149], 'Immunother.': [1150], '50:': [1152], '483-490Google': [1153], 'E-cadherin': [1155, 1238], '(18Berx': [1156], 'Van': [1158], 'Roy': [1159], 'E-cadherin/catenin': [1162], 'complex:': [1163], 'An': [1164, 1406], 'important': [1165, 1539], 'gatekeeper': [1166], 'tumorigenesis': [1170], 'progression..Breast': [1173], '3:': [1177, 1226, 1245, 1496], '289-293Google': [1178], 'transforming': [1180], 'factor-β': [1182, 1188, 1211, 1481], 'system': [1183], '(19Kretzschmar': [1184], 'Transforming': [1186, 1192, 1209, 1479], 'factor-β/SMAD': [1194], 'signaling': [1195], 'defects': [1196], 'cancer..Breast': [1198, 1793, 1861], '107-115Google': [1203], '20Pollard': [1205, 1475], 'J.W.': [1206, 1476], 'Tumour-stromal': [1207, 1477], 'interactions.': [1208, 1478], 'isoforms': [1212, 1482], 'hepatocyte': [1214, 1444, 1484, 1510], 'factor/scatter': [1216, 1486], 'factor': [1217, 1250, 1374, 1427, 1446, 1487, 1512, 1569], 'ductal': [1221, 1491, 1751, 2146, 2356, 2405], 'morphogenesis..Breast': [1222, 1492], '230-237Google': [1227, 1497], '21Fearon': [1229], 'E.R.': [1230], 'Connecting': [1231], 'function,': [1234], 'transcriptional': [1235], 'repression,': [1236], 'expression': [1239], 'cancer..Cancer': [1242], 'Cell.': [1243, 1288, 1640, 2081, 2319], '307-310Google': [1246], '(EGF)': [1251], '(22Normanno': [1252], 'Ciardiello': [1254], 'EGF-related': [1256], 'peptides': [1257, 2929, 2944, 2972, 3232, 3386, 3416, 3462, 3521], 'pathophysiology': [1260], 'gland..J.': [1264], '1997;': [1269], '143-151Google': [1271], 'EGF': [1273, 1350], 'receptor-2': [1274], '(HER-2/neu;': [1275], 'c-erbB-2)': [1276], '(23Yarden': [1277], 'Y.': [1278, 2999], 'Sliwkowski': [1279], 'M.X.': [1280], 'Untangling': [1281], 'ErbB': [1283], 'signalling': [1284], 'network..Nat.': [1285], 'Rev.': [1286, 1439, 1581], 'Mol.': [1287], '127-137Google': [1292], '24Baselga': [1294], 'Hammond': [1296], 'HER-targeted': [1298], 'tyrosine-kinase': [1299], 'inhibitors..Oncology.': [1300], '63': [1302], '1:': [1303, 1642], '6-16Google': [1304], '25Ross': [1306], 'Fletcher': [1308], 'J.A.': [1309], 'Linette': [1310], 'G.P.': [1311], 'Stec': [1312], 'Clark': [1314], 'Ayers': [1316], 'Symmans': [1318], 'W.F.': [1319], 'Pusztai': [1320], 'L.': [1321, 2054, 2292], 'Bloom': [1322], 'K.J.': [1323], 'Her-2/neu': [1325], 'gene': [1326], '2003:': [1332], 'Biomarker': [1333], 'target': [1335, 1408, 1658, 3036, 3090], 'therapy..Oncologist.': [1337], '8:': [1339], '307-325Google': [1340], '26Earp': [1342], '3rd,': [1343], 'H.S.': [1344], 'Calvo': [1345], 'B.F.': [1346], 'Sartor': [1347], 'C.I.': [1348], 'family—Multiple': [1352], 'roles': [1353], 'differentiation,': [1356], 'neoplasia': [1358], 'an': [1360, 2583, 3148, 3157, 3477, 3568, 3844], 'emphasis': [1361], 'HER4..Trans.': [1363], 'Am.': [1364], 'Clin.': [1365], 'Climatol.': [1366], 'Assoc.': [1367], '114:': [1369], '315-333Google': [1370], 'insulin': [1372], '1': [1375, 2559, 2613, 3505, 3633, 3798, 3803], '(27Helle': [1376], 'S.I.': [1377], 'Lonning': [1378], 'P.E.': [1379], 'Insulin-like': [1380], 'cancer..Acta': [1385], 'Oncol.': [1386, 1971], '1996;': [1387, 2897], '35:': [1388, 1416], '19-22Google': [1389], '28Gray': [1391], 'S.G.': [1392], 'Stenfeldt': [1393], 'Mathiasen': [1394], 'I.': [1395, 2023, 2261, 2385, 2762], 'De': [1396], 'Meyts': [1397], 'insulin-like': [1400, 1425, 1567], 'insulin-signalling': [1404], 'systems:': [1405], 'appealing': [1407], 'therapy?.Horm.': [1412], 'Metab.': [1413], '857-871Google': [1417], '29Gross': [1419], 'J.M.': [1420, 1562, 2025, 2263], 'Yee': [1421, 1563], 'D.': [1422, 1564, 1629], 'type-1': [1424, 1566], 'tyrosine': [1429, 1571], 'kinase': [1430, 1572, 1635], 'Biology': [1434, 1576, 2479], 'relevance..Cancer': [1437, 1579], 'Metastasis': [1438, 1580], '327-336Google': [1442, 1584], '(9Haslam': [1447], 'S.Z.': [1448], 'Woodward': [1449], 'T.L.': [1450], 'Host': [1451], 'development:': [1456], 'Epithelial-cell-stromal-cell': [1457], 'steroid': [1460], 'hormone': [1461], 'action': [1462], 'normal': [1464, 3684, 4054], 'cancerous': [1466], 'gland..Breast': [1468], '5:': [1472], '208-215Google': [1473], '30Elliott': [1499], 'B.E.': [1500], 'Hung': [1501], 'W.L.': [1502], 'Boag': [1503], 'A.H.': [1504], 'Tuck': [1505], 'A.B.': [1506], '(scatter': [1513], 'factor)': [1514], 'epithelial-mesenchymal': [1516], 'transition': [1517], 'cancer..Can.': [1520], 'Physiol.': [1522], 'Pharmacol.': [1523], '80:': [1525, 1798, 1866], '91-102Google': [1526], 'other': [1532], 'factors.': [1533], 'Some': [1534], 'represent': [1538], 'candidates': [1540], 'therapy': [1543, 1615], 'targeting': [1544], 'dynamic': [1548], 'modulate': [1553], '(29Gross': [1561], '31Shao': [1586], 'Brown': [1588], 'Advances': [1590], 'biology:': [1594], 'Prospects': [1595], 'improvements': [1597], 'targeted': [1599], 'therapy..Breast': [1602], '39-52Google': [1607], '32Ulrich': [1609], 'impact': [1618], 'management..Oncology.': [1621], '63:': [1623], '1-5Google': [1624], '33Shawver': [1626], 'L.K.': [1627], 'Slamon': [1628], 'Ullrich': [1630], 'Smart': [1632], 'drugs:': [1633], 'Tyrosine': [1634], 'inhibitors': [1636], 'therapy..Cancer': [1639], '117-123Google': [1643], '34Erickson': [1645], 'Barcellos-Hoff': [1647], 'M.H.': [1648], 'not-so': [1650], 'innocent': [1651], 'bystander:': [1652], 'cancer..Expert': [1660], 'Opin.': [1661], 'Ther.': [1662], 'Targets.': [1663], '71-88Google': [1666], 'With': [1668], 'advent': [1670], 'enabling': [1672], 'technologies': [1673, 1714, 1762, 2008, 2074, 2312], 'proteomics,': [1675, 2010], 'now': [1678], 'feasible': [1679], 'undertake': [1681], 'systematic': [1683, 2167], 'characterization': [1684, 1782, 1850], 'released': [1690], 'resident': [1700], 'main': [1706], 'challenge,': [1707], 'however,': [1708, 2091], 'remains': [1709], 'application': [1711], 'samples': [1718, 2005, 2565, 3715], 'well-defined': [1721], 'framework.': [1725], 'Toward': [1726, 2119], 'this': [1727, 2120, 2178, 2254, 2554, 3587], 'aim,': [1728, 2121], 'efforts': [1729], 'made': [1732, 3551], 'characterize': [1734], '(NAF),': [1743], 'contains': [1745], 'directly': [1747, 3033], 'secreted': [1748], 'lobular': [1753], 'epithelium,': [1754], 'patients': [1756, 2327], 'using': [1760, 2002, 2177, 2410, 2437, 2751, 2805, 2932, 2958, 3122, 3147, 3176, 3252, 3272, 3364, 3583, 3648, 3747, 4069], 'proteomic': [1761, 2070, 2308], '(35Varnum': [1763, 1831], 'S.M.': [1764, 1832], 'Covington': [1765, 1833], 'Woodbury': [1767, 1835], 'Petritis': [1769, 1837], 'K.': [1770, 1838, 2062, 2300], 'Kangas': [1771, 1839], 'L.J.': [1772, 1840], 'Abdullah': [1773, 1841], 'M.S.': [1774, 1842], 'Pounds': [1775, 1843], 'J.G.': [1776, 1844], 'Smith': [1777, 1845], 'Zangar': [1779, 1847], 'R.C.': [1780, 1848], 'Proteomic': [1781, 1849, 1911], 'fluid:': [1786, 1854], 'Identification': [1787, 1855], 'biomarkers': [1790, 1858, 1923, 1989, 2101, 2171], 'Treat.': [1796, 1864], '87-97Google': [1799, 1867], 'study': [1802, 2255, 2555], '64': [1804], 'proteins,': [1805], 'some': [1806], 'which,': [1808], 'like': [1809], 'cathepsin': [1810, 3914], 'D': [1811], 'osteopontin,': [1813], 'had': [1814, 2329], 'previously': [1815, 2684, 2792, 3656, 3734], 'found': [1817], 'be': [1819, 3355, 3677], 'deregulated': [1820], 'women': [1827, 2199], 'NAF': [1869, 1941], 'also': [1871, 3376], 'surface-enhanced': [1875], 'desorption': [1877], 'ionization': [1878], 'time-of-flight,': [1879], 'signatures': [1882], 'discovered': [1885], 'appear': [1887], 'differentiate': [1889], 'healthy': [1894], 'controls': [1895], '(36Paweletz': [1896], 'C.P.': [1897], 'Trock': [1898], 'B.': [1899, 3926, 3951], 'Pennanen': [1900], 'Tsangaris': [1902], 'Magnant': [1904], 'Liotta': [1906], 'Petricoin': [1908], '3rd.,': [1909], 'E.F.': [1910], 'patterns': [1912], 'fluids': [1916, 2660], 'obtained': [1917, 3139, 3904], 'SELDI-TOF:': [1919], 'Potential': [1920], 'aid': [1925, 2581], 'diagnosis': [1928, 1966], 'cancer..Dis.': [1931], 'Markers.': [1932], '17:': [1934], '301-307Google': [1935], 'detected': [1939, 3618, 4079], 'carcinoembryonic': [1943], 'antigen,': [1944, 1946], 'prostate-specific': [1945], 'lactate': [1947], 'dehydrogenase,': [1948], 'basic': [1949], 'fibroblast': [1950], 'factor,': [1952, 1956], 'vascular': [1953], 'c-erbB-2': [1958], '(37Shao': [1959], 'Z.M.': [1960], 'Nguyen': [1961], 'Nipple': [1963], 'aspiration': [1964], 'cancer..Semin.': [1969], 'Surg.': [1970], '20:': [1973, 3277], '175-180Google': [1974], 'our': [1980, 2160], 'laboratories,': [1981], 'interested': [1984], 'intervention': [1998, 2176], 'cutting-edge': [2007], 'functional': [2011, 2072, 2310], 'genomics,': [2012], 'cellular': [2014], 'molecular': [2016, 3285, 3424, 3513], '(38Celis': [2018, 2256], 'Gromov': [2020, 2258, 2690, 2796, 3738], 'Gromova': [2022, 2260], 'Moreira': [2024, 2262], 'Cabezon': [2026, 2264], 'Ambartsumian': [2028, 2266], 'Grigorian': [2030, 2268], 'Lukanidin': [2032, 2270], 'Thor': [2034, 2272], 'Straten': [2035, 2273], 'Guldberg': [2037, 2275], 'Bartkova': [2039, 2277], 'Bartek': [2041, 2279], 'Lukas': [2043, 2045, 2281, 2283], 'Lykkesfeldt': [2047, 2285], 'Jaattela': [2049, 2287], 'Roepstorff': [2051, 2289], 'Bolund': [2053, 2291], 'Orntoft': [2055, 2293], 'Brunner': [2057, 2295], 'Overgaard': [2059, 2297], 'Sandelin': [2061, 2299], 'Blichert-Toft': [2063, 2301], 'Mouridsen': [2065, 2303], 'Rank': [2067, 2305], 'F.E.': [2068, 2306], 'Integrating': [2069, 2307], 'genomic': [2073, 2311], 'discovery-driven': [2076, 2314], 'translational': [2077, 2315], 'research..Mol.': [2080, 2318], 'Proteomics.': [2082, 2320], '369-377Google': [2085, 2323], 'To': [2087], 'achieve': [2088], 'goals,': [2090], 'necessary': [2095], 'identify': [2097], 'mirror': [2103], 'vivo': [2106], 'situation': [2107], 'accurately': [2109], 'possible,': [2111], 'amenable': [2115], 'multifactorial': [2117], 'analysis.': [2118, 2658, 3556], 'here': [2124], 'breast.': [2150], 'Besides': [2151], 'providing': [2152], 'overview': [2155], 'proteome,': [2159], 'results': [2161], 'open': [2162], 'possibility': [2164], 'search': [2168, 3322, 3394, 3430, 3435, 3494], 'resource.': [2180], 'Access': [2181], 'large': [2183], 'tumors': [2184, 2351], 'was': [2185, 2388, 2488, 2577, 2617, 2650, 2789, 2903, 2953, 3120, 3245, 3340, 3362, 3395, 3407, 3474, 3549, 3560, 3581, 3603, 3645, 4008, 4051, 4067, 4078], 'deemed': [2186], 'essential,': [2187], 'chosen': [2190], 'required': [2192, 3678], 'substantial': [2193], 'amounts': [2194, 2942], 'material.': [2197, 2492], 'Consequently,': [2198], 'operable': [2202], 'high-risk': [2203, 2207], '2The': [2204], 'criteria': [2205], 'applied': [2209, 2730, 3432], 'Danish': [2212], 'Cooperative': [2213], 'Breast': [2214], 'Group': [2216], 'age': [2218, 2360], 'below': [2219], '35': [2220, 2725], 'years': [2221], 'old,': [2222], 'and/or': [2223, 2231, 2244, 3836], 'diameter': [2225], '20': [2229, 2595, 2723, 2917, 3778, 4039], 'mm,': [2230], 'histological': [2232, 2368], 'malignancy': [2233], '3,': [2236], 'and/or,': [2237], 'negative': [2238], 'status,': [2243, 2371, 2374], 'positive': [2245, 3141], 'axillary': [2246, 2348, 2372], 'status.': [2247], 'were': [2251, 2352, 2456, 2469, 2501, 2534, 2556, 2566, 2588, 2665, 2729, 2743, 2749, 2817, 2837, 2858, 2930, 2945, 2986, 3024, 3069, 3106, 3138, 3172, 3189, 3204, 3213, 3237, 3291, 3318, 3352, 3431, 3496, 3594, 3617, 3716, 3728, 3760, 3780, 3809, 3828, 3857, 3903, 3922, 3961, 3974, 4032], 'selected': [2252], 'All': [2325, 2350, 3136, 3202], '16': [2326], 'no': [2330, 2950], 'previous': [2331], 'surgery': [2332, 2467], 'did': [2337, 3327, 3527], 'receive': [2339], 'preoperative': [2340], 'treatment.': [2341], 'Patients': [2342], 'underwent': [2343], 'mastectomy': [2344], '(Fig.': [2345, 2508], '1A),': [2346], 'including': [2347], 'dissection.': [2349], 'diagnosed': [2353], 'carcinomas.': [2357], 'Data': [2358], 'concerning': [2359], 'patient,': [2363], 'size': [2364], 'tumor,': [2367], 'grade,': [2369], 'HER-2/neu': [2370], 'nodal': [2373, 2414], 'status': [2380], 'Table': [2384], 'project': [2387], 'approved': [2389], 'Scientific': [2392], 'Ethical': [2394], 'Committee': [2395], 'Copenhagen': [2398], 'Frederiksberg': [2400], 'Municipalities': [2401], '(KF': [2402], '01-069/03).Table': [2403], 'IInvasive': [2404], 'carcinomasPatient': [2406], 'numberAgeSizeHistological': [2407], 'gradeHer-2/neu': [2408], 'statusaDetermined': [2409], 'Hercep': [2411, 2438], 'Test™': [2412, 2439], '(Dako).Axillary': [2413], 'statusbPositive/total.Receptor': [2415], 'statusERcER,': [2416], 'receptor.PGRdPGR,': [2418], 'receptor.mm274720200': [2420], '/15ER+PGR+285324333': [2421], '/12ER+PGR+29451320NDER+PGR+306926231': [2422], '/6ER+PGR+318922116': [2423], '/15ER+PGR+336821231': [2424], '/11ER+PGR+346923213': [2425], '/12ER+PGR+364850238': [2426], '/18ER+PGR+378016100': [2427], '/1ER+PGR−386225222': [2428], '/13ER+PGR−397330120': [2429], '/13ER+PGR−405230220': [2430], '/14ER+PGR+416835331': [2431], '/18ER−PGR−425421325': [2432], '/10ER−PGR−444270217': [2433], '/11ER+PGR+456528124': [2434], '/14ER+PGR+a': [2435], 'Determined': [2436], '(Dako).b': [2440], 'Positive/total.c': [2441], 'ER,': [2442], 'receptor.d': [2444], 'PGR,': [2445], 'receptor.': [2447], 'Open': [2448], 'table': [2449], 'tab': [2453], 'Tissue': [2454], 'biopsies': [2455, 2500], 'Pathology': [2460], 'Department': [2461], 'Righshospitalet': [2463], '20–30': [2464], 'min': [2465, 2573, 2596, 2830, 2918, 3784, 3815, 4040], 'after': [2466, 2558], 'rapidly': [2470], 'transported': [2471], 'ice': [2473], 'Institute': [2476], 'further': [2481, 2589], 'processing.': [2482], 'A': [2483, 2645, 2711, 2772, 2779, 3704], 'fraction': [2484, 2646], 'each': [2486, 2746], 'sample': [2487, 2728, 3014], 'stored': [2489], 'archival': [2491, 3970], 'About': [2493], '0.25': [2494, 3606], 'g': [2495], 'clean': [2497], 'fresh': [2498], 'cut': [2502, 2848, 3975], 'into': [2503, 2849], '(1–3': [2506], 'mm3)': [2507], '1B),': [2509], 'washed': [2510, 3107, 3811], 'carefully': [2511], '5': [2513, 3814], 'ml': [2514, 2530, 2623, 3607], 'phosphate': [2516], 'buffered': [2517], 'saline': [2518], '(PBS),': [2519], 'placed': [2521, 3963], '10-ml': [2524], 'conical': [2525], 'plastic': [2526], 'tube': [2527], 'containing': [2528, 2991, 3766, 3790], '0.8': [2529, 3075], 'PBS.': [2532], 'Samples': [2533, 2587, 3068], 'incubated': [2535, 3604, 3781], 'different': [2537], 'periods': [2538], '(0–24': [2541], 'h)': [2542], '37': [2544], '°C': [2545, 2654, 3612, 3842, 3994], 'humidified': [2548], 'CO2': [2549], 'incubator.': [2550], 'h': [2560, 2873], 'incubation.': [2562], 'Thereafter,': [2563], 'centrifuged': [2567, 2590], '1,000': [2569], 'rpm': [2570, 2593], 'supernatant': [2576, 2934, 3079], 'aspirated': [2578], 'elongated': [2584], 'Pasteur': [2585], 'pipette.': [2586], '5,000': [2592], 'refrigerated': [2599], 'centrifuge': [2600], '(4': [2601], '°C).': [2602], 'final': [2604], 'supernatant,': [2605], 'concentration': [2609, 3802], 'ranged': [2611], '4': [2615, 3611], 'mg/ml,': [2616], 'freeze-dried': [2618], 'resuspended': [2620, 2661], '0.5': [2622], 'lysis': [2625, 2663], 'solution': [2626, 2664, 3765], "(39O'Farrell": [2627], 'P.H.': [2628], 'High': [2629], 'resolution': [2630], 'proteins..J.': [2634], 'Chem.': [2636, 2896, 3018], '1975;': [2637], '250:': [2638], '4007-4021Abstract': [2639], 'Full': [2640], 'Text': [2641], 'PDF': [2642], 'Google': [2643], 'kept': [2651], '–20': [2653], 'array-based': [2657, 3584], 'Freeze-dried': [2659], 'subjected': [2666, 3717, 3829], 'focusing': [2670, 2701], '(IEF)': [2671, 2702], '(NEPHGE)': [2677], '(2D': [2681], 'PAGE)': [2682], 'described': [2685, 2793, 2875, 3657, 3735], '(40Celis': [2686], 'Trentemølle': [2688], 'Gel-based': [2692], 'proteomics:': [2693], 'High-resolution': [2694, 2798, 3740], 'Isoelectric': [2700], '(NEPHGE).in:': [2708], 'Cell': [2709, 2777, 3702], 'Biology.': [2710, 2778, 3703], 'Laboratory': [2712, 2780, 3705], 'Handbook.': [2713, 2781, 3706], '4.': [2714, 2782, 3707], 'Academic': [2715, 2783, 3708], 'Press,': [2716, 2784, 3709], 'San': [2717, 2785, 3710, 3894], 'Diego,': [2718, 3895], 'press2004Google': [2720], 'Between': [2722], 'μl': [2726, 3076], 'dimension,': [2734], 'least': [2737], 'three': [2738], 'IEF': [2739, 3720], 'NEPHGE': [2741, 3722], 'gels': [2742, 2768, 2822, 3526], 'run': [2744], 'sample.': [2747], 'Proteins': [2748, 2857], 'visualized': [2750], 'silver': [2753, 2770], 'staining': [2754, 4048], 'procedure': [2755, 2773, 3053], 'compatible': [2756, 2774], 'spectrometry': [2759, 3119, 3274], '(41Gromova': [2761], 'Celis': [2763, 3660, 3692], 'Protein': [2765, 2815, 3714], 'staining:': [2771], 'mass-spectrometry.in:': [2776], 'Diego2004Google': [2786], 'Immunoblotting': [2788], 'performed': [2790, 3121, 3246, 3363, 3396, 3475, 4009], '(42Celis': [2794, 3736], 'western': [2806, 3748], 'blotting': [2807, 3749], 'ECL': [2809, 3751], 'detection..EXS.': [2810, 3752], '88:': [2812, 3754], '55-67Google': [2813, 3755], 'bands': [2816], 'excised': [2818], 'dry': [2821], 'followed': [2823, 2913, 3095, 4085], 'rehydration': [2825], 'water': [2827], '30': [2829, 4075], 'room': [2832, 2920, 4036], 'temperature.': [2833], 'detached': [2838], 'cellophane': [2841], 'film,': [2842], 'rinsed': [2843, 3761, 4042], 'twice': [2844, 3108, 3762], 'water,': [2846], 'about': [2850], '1-mm2': [2851], 'subsequent': [2854], 'additional': [2855, 3415, 3478], 'washes.': [2856], '"in-gel"': [2859], 'digested': [2860, 3078], 'bovine': [2862], 'trypsin': [2863, 3223], '(unmodified,': [2864], 'sequencing': [2865, 2890, 3539], 'grade;': [2866], 'Roche': [2867], 'Diagnostics,': [2868], 'Mannheim,': [2869], 'Germany)': [2870], '12': [2872], 'Shevchenko': [2877], 'colleagues': [2879], '(43Shevchenko': [2880], 'Wilm': [2882], 'Vorm': [2884], 'Mann': [2886, 3000], 'Mass': [2888, 3118, 3370], 'spectrometric': [2889], 'silver-stained': [2893, 3525], 'gels..Anal.': [2895], '68:': [2898], '850-858Google': [2899], 'reaction': [2902], 'stopped': [2904], 'adding': [2906], 'acid': [2908, 3045], '(TFA,': [2909], '0.4%)': [2912], 'shaking': [2915], 'temperature': [2921, 4037], 'increase': [2923], 'peptide': [2924, 2956, 3325, 3358, 3405, 3498, 3538], 'recovery.': [2925], 'cases,': [2928], '(SN).': [2935], 'few': [2938], 'cases': [2939, 3455, 3566], 'where': [2940], 'too': [2946], 'low,': [2947], 'when': [2949], 'conclusive': [2951, 3542], 'achieved': [2954, 3561], 'fingerprinting': [2957, 3360], 'remaining': [2962], 'amount': [2963, 3057, 3519], 'SN': [2965, 3467], '(∼10': [2966], 'μl)': [2967], 'additionally': [2973], 'extracted': [2974, 3469, 3522], '1%': [2980], 'TFA': [2981, 3032, 3111], '50%': [2983, 3030], 'acetonitrile': [2984], '(ACN)': [2985], 'concentrated': [2987], 'micro': [2989], 'columns': [2990], 'C18-based': [2992], '3-mm': [2993], 'Empore': [2994], 'plugs': [2995], '(44Rappsilber': [2996], 'Ishihama': [2998], 'Stop': [3002], 'go': [3004], 'extraction': [3005, 3052], 'tips': [3006], 'desorption/ionization,': [3010], 'nanoelectrospray,': [3011], 'LC/MS': [3013], 'pretreatment': [3015], 'proteomics..Anal.': [3017], '75:': [3020], '663-670Google': [3021], 'Peptides': [3023], 'eluted': [3025], 'column': [3028], 'ACN/0.2%': [3031], 'co-crystallized': [3038], 'cyano': [3040], '(2': [3042], 'mg/ml': [3043], 'cyano-4-hydroxycinnamic': [3044], '0.5%': [3047], 'TFA/ACN,': [3048], '1.2': [3049], 'v/v).': [3050], 'strongly': [3054, 3667], 'increased': [3055], 'peptides,': [3059], 'thus': [3060], 'allowing': [3061], 'direct': [3062], 'sequence': [3063, 3270, 3464, 3570], 'low-intensity': [3066], 'peptides.': [3067], 'prepared': [3070, 3858], 'applying': [3074], 'microcolumn-eluted': [3081], 'material': [3082], 'surface': [3085], '400/384': [3088], 'AnchorChip': [3089], '(Bruker': [3091, 3200], 'Daltonik,': [3092], 'Billerica,': [3093], 'MA),': [3094], 'co-crystallization': [3097], '0.3-μl': [3099], 'α-cyano': [3100], 'matrix.': [3101], 'After': [3102], 'drying,': [3103], 'droplets': [3105], '2%': [3110], 'remove': [3113], 'contamination': [3114, 3227], 'samples.': [3117], 'Reflex': [3124], 'IV': [3125], 'MALDI-TOF': [3126], 'spectrometer': [3128], 'equipped': [3129], 'Scout': [3132], '384': [3133], 'ion': [3134], 'source.': [3135], 'spectra': [3137, 3171, 3188, 3203, 3236], 'reflector': [3142], 'mode': [3143], 'delayed': [3145], 'extraction,': [3146], 'accelerating': [3149], 'voltage': [3150], '28': [3152], 'kV.': [3153], 'Each': [3154, 3601], 'spectrum': [3155], 'represented': [3156], 'average': [3158, 3569], '100–200': [3160], 'shots,': [3162], 'depending': [3163], 'signal-to-noise': [3166], 'ratio.': [3167], 'resulting': [3169], 'internally': [3173], 'calibrated': [3174], 'auto-digested': [3178], 'tryptic': [3179], 'values': [3181, 3426], '(805.417/906.505/1153.574/1433.721/2163.057/2273.160)': [3182], 'visible': [3183], 'spectra.': [3186], 'Calibrated': [3187], 'processed': [3190], 'Xmass': [3193], '5.1.1': [3194], 'BioTools': [3196], '2.1': [3197], 'software': [3198, 3256, 3380], 'packages': [3199], 'Daltonik).': [3201], 'manually.': [3206], 'Spectra': [3207], 'originating': [3208], 'parallel': [3210], 'digestions': [3212], 'compared': [3214, 3408], 'pairwise': [3215], 'discard': [3217], 'common': [3218], 'peaks': [3219, 3531], 'derived': [3220], 'either': [3221], 'auto-digestion': [3224], 'keratins.': [3229], 'Only': [3230, 3342], 'search.': [3242], 'Database': [3243], 'searching': [3244, 3269], 'against': [3247, 3849, 3864, 3909], 'comprehensive': [3249], 'nonredundant': [3250], 'database': [3251], 'MASCOT': [3254], '1.8': [3255], '(45Perkins': [3257], 'D.N.': [3258], 'Pappin': [3259], 'D.J.': [3260], 'Creasy': [3261], 'Cottrell': [3263], 'Probability-based': [3265], 'databases': [3271], 'data..Electrophoresis.': [3275], '1999;': [3276], '3551-3567Google': [3278], 'without': [3280, 3507], 'restriction': [3281, 3509], 'taxonomy.': [3288, 3516], 'Because': [3289, 3517], 'recovered': [3292], 'dried': [3294], 'gels,': [3295], 'number': [3297], 'fixed': [3299], 'modifications': [3300], '(acrylamide': [3301], 'cystein,': [3303], 'i.e.': [3304], 'propionamide/carbamidomethylation)': [3305], 'variable': [3309], 'ones': [3310], '(methionine': [3311], 'oxidation': [3312], 'N': [3315], 'terminus': [3316], 'acetylation),': [3317], 'included': [3319], 'parameters.': [3323], 'tolerance': [3326, 3499, 3504], 'exceed': [3329], '50': [3330, 3500, 3767], 'ppm': [3331, 3501], 'maximum': [3335], 'only': [3336], 'missed': [3338], 'cleavage': [3339], 'allowed.': [3341], 'identifications': [3344, 3399], 'score': [3346], 'greater': [3347], 'p': [3349], '<': [3350], '0.05': [3351], 'considered': [3353], 'positive.': [3356], 'Additionally,': [3357], 'MS-Fit': [3366], 'program': [3367], '(ProteinProspector;': [3368], 'UCSF': [3369], 'Spectrometry': [3371], 'Facility,': [3372], 'London,': [3373], 'UK).': [3374], 'Find-Mod': [3379], '(ProteinProspector)': [3381], 'check': [3383], 'unmatched': [3385, 3423], 'post-translational': [3390, 3489], 'modifications.': [3391, 3490], 'second': [3393, 3445], 'follows:': [3401], '1)': [3402], 'predicted': [3404], 'digest': [3406], 'experimental': [3411], 'reveal': [3414], 'spectra;': [3420], '2)': [3421], 'initial': [3429], 'extra': [3434], 'reproducibility': [3439], 'requirements': [3440], 'third': [3448], 'spot.': [3452], 'intensity': [3459], 'allowed': [3463], '(either': [3466], 'material),': [3470], 'decay': [3472], '(PSD)': [3473], 'mean': [3479], 'confirm': [3481], 'identity': [3483], 'following': [3492], 'PSD': [3493, 3543, 3555], 'parameters': [3495], 'used:': [3497], 'MS/MS': [3503], 'Da': [3506], 'yield': [3529], 'overall': [3530], 'intensities': [3532], 'high': [3533], 'enough': [3534], 'allow': [3536], 'multiple': [3537, 3576], '(prerequirement': [3540], 'analysis),': [3544], 'never': [3550], 'solely': [3552], 'based': [3553], 'Positive': [3557], '80%': [3563], 'coverage': [3571], '∼33%.': [3573], 'Detection': [3574], 'done': [3582], 'technology.': [3585], 'For': [3586], 'purpose,': [3588], 'RayBio™': [3589], 'Cytokine': [3590], 'Antibody': [3591], 'Arrays': [3592], '5.1': [3593], 'purchased': [3595], 'RayBiotech,': [3597], 'Inc.': [3598], '(Atlanta,': [3599], 'GA).': [3600], 'array': [3602, 3630], 'overnight,': [3613], 'bound': [3615], 'according': [3619], "manufacturer's": [3622], 'instructions.': [3623], 'sensitivity': [3625], 'cytokine': [3628], 'ranges': [3631], '2,000': [3635], 'pg/ml.': [3636], 'profiling': [3640], 'GTP-binding': [3643, 3664, 3699], 'carried': [3646], 'out': [3647], '[α-32P]GTP': [3650, 3800], 'blot': [3651], 'overlay': [3652, 3695], 'assay': [3653, 3696], 'essentially': [3654], '(46Gromov': [3658], 'P.S.': [3659], 'Several': [3662], 'down': [3668], 'regulated': [3669], 'SV40': [3671], 'transformed': [3672], 'human': [3673], 'keratinocytes': [3674], 'maintainance': [3681], 'phenotype..Electrophoresis.': [3685], '1994;': [3686], '15:': [3687], '474-481Google': [3688], '47Gromov': [3690], 'Blot': [3694], 'identification.in:': [3701], 'Diego1997:': [3711], '454-458Google': [3712], 'electro-transferred': [3729], 'nitrocellulose': [3731, 3758, 3807], 'membranes': [3732, 3808, 3827], 'filters': [3759], 'mm': [3768, 3792, 4015], 'Tris-HCl,': [3769], '7.6,': [3771], '10': [3772, 4014, 4028], 'μm': [3773, 3795], 'MgCl2,': [3774], '0.3%': [3776, 4070], 'Tween': [3777], '60': [3783, 3993, 3996], 'buffer,': [3788], '100': [3791, 3794], 'dithiothreitol,': [3793, 3822], 'ATP,': [3796, 3823], 'nm': [3799], '(final': [3801], 'μCi': [3804], '[α-32P]GTP/ml).': [3805], 'then': [3810, 4033], 'four': [3812], 'times,': [3813], 'each,': [3816], 'buffer': [3820, 4017], 'lacking': [3821], '[α-32P]GTP.': [3825], 'Air-dried': [3826], 'phosphorimaging': [3831], '(FLA3000;': [3832], 'Fuji,': [3833], 'Tokyo,': [3834], 'Japan)': [3835], 'exposed': [3837], 'autoradiography': [3839], '−70': [3841], 'intensifying': [3845], 'screen.': [3846], 'Anti-peptide': [3847], 'antibodies': [3848], 'thioredoxin,': [3850], 'controlled': [3853], 'protein,': [3854], '14-3-3σ': [3856], 'Eurogentec': [3860], '(Brussels,': [3861], 'Belgium).': [3862], 'Antibodies': [3863, 3908], 'metastasin': [3865], '(Prolifia': [3866], 'Inc.,': [3867], 'Tucson,': [3868], 'AZ),': [3869], 'neutrophils': [3870], '(neutrophil': [3871], 'elastase;': [3872], 'Dako,': [3873], 'Glostrup,': [3874], 'Denmark),': [3875, 3956], '(CD68;': [3877], 'Dako),': [3878, 3884, 3889], 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