Title: Voriconazole‐induced QT interval prolongation and torsades de pointes
Abstract: Pediatrics InternationalVolume 53, Issue 5 p. 761-763 Voriconazole-induced QT interval prolongation and torsades de pointes Ebru Aypar, Corresponding Author Ebru Aypar Pediatric Cardiology UnitEbru Aypar, MD, Pediatric Cardiology Unit, Department of Pediatrics, Ankara University Faculty of Medicine, 06100, Cebeci, Ankara, Turkey. Email: [email protected]Search for more papers by this authorTanıl Kendirli, Tanıl Kendirli Pediatric Intensive Care UnitSearch for more papers by this authorErcan Tutar, Ercan Tutar Pediatric Cardiology UnitSearch for more papers by this authorErgin Çiftçi, Ergin Çiftçi Pediatric Infectious Diseases UnitSearch for more papers by this authorErdal Ince, Erdal Ince Pediatric Infectious Diseases UnitSearch for more papers by this authorTalia Ileri, Talia Ileri Pediatric Hematology Unit, Department of Pediatrics, Ankara University Faculty Of Medicine, Ankara, TurkeySearch for more papers by this authorSemra Atalay, Semra Atalay Pediatric Cardiology UnitSearch for more papers by this author Ebru Aypar, Corresponding Author Ebru Aypar Pediatric Cardiology UnitEbru Aypar, MD, Pediatric Cardiology Unit, Department of Pediatrics, Ankara University Faculty of Medicine, 06100, Cebeci, Ankara, Turkey. Email: [email protected]Search for more papers by this authorTanıl Kendirli, Tanıl Kendirli Pediatric Intensive Care UnitSearch for more papers by this authorErcan Tutar, Ercan Tutar Pediatric Cardiology UnitSearch for more papers by this authorErgin Çiftçi, Ergin Çiftçi Pediatric Infectious Diseases UnitSearch for more papers by this authorErdal Ince, Erdal Ince Pediatric Infectious Diseases UnitSearch for more papers by this authorTalia Ileri, Talia Ileri Pediatric Hematology Unit, Department of Pediatrics, Ankara University Faculty Of Medicine, Ankara, TurkeySearch for more papers by this authorSemra Atalay, Semra Atalay Pediatric Cardiology UnitSearch for more papers by this author First published: 28 September 2011 https://doi.org/10.1111/j.1442-200X.2010.03321.xCitations: 15Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Towbin JA, Friedman RA. Long QT syndrome. In: EP Walsh, JP Saul, JK Triedman (eds). Cardiac Arrhythmias in Children and Young Adults with Congenital Heart Disease. Lippincott Williams & Wilkins, Philadelphia, PA, 2001; 235–70. 2 Scott LJ, Simpson D. Voriconazole: A review of its use in the management of invasive fungal infections. Drugs 2007; 67: 269–98. 3 Alkan Y, Haefeli WE, Burhenne J, Stein J, Yaniv I, Shalit I. Voriconazole-induced QT interval prolongation and ventricular tachycardia: A non-concentration-dependent adverse effect. Clin. Infect. Dis. 2004; 39: e49–52. 4 Philips JA, Marty FM, Stone RM, Koplan BA, Katz JT, Baden LR. Torsades de pointes associated with voriconazole use. Transpl. Infect. Dis. 2007; 9: 33–6. 5 Zimmermann M, Duruz H, Guinand O et al. Torsades de pointes after treatment with terfenadine and ketoconazole. Eur. Heart J. 1992; 13: 1002–3. 6 Esch JJ, Kantoch MJ. Torsades de pointes ventricular tachycardia in a pediatric patient treated with fluconazole. Pediatr. Cardiol. 2008; 29: 210–13. 7 Falagas ME, Rafailidis PI, Rosmarakis ES. Arrhythmias associated with fluoroquinolone therapy. Int. J. Antimicrob. Agents 2007; 29: 374–9. 8 El-Sherif N. T-wave alternans: A marker of vulnerability to ventricular tachyarrhythmias. In: A Raviele (ed). Cardiac Arrhythmias. Springer, Milan, 1995; 12–16. 9 Chao CL, Chen WJ, Wu CC, Lee YT. Torsade de pointes and T-wave alternans in a patient with brainstem hemorrhage. Int. J. Cardiol. 1995; 51: 199–201. 10 Alehan D, Ceviz N, Celiker A. Torsades de pointes associated with encephalitis. Turk. J. Pediatr. 1999; 41: 395–8. 11 FDA Antiviral Drugs Advisory Committee. Briefing Document for Voriconazole (Oral and Intravenous Formulations). [Accessed 4 October 2001]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3792b2_01_Pfizer.pdf 12 Weiss J, Ten Hoevel MM, Burhenne J et al. CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole. J. Clin. Pharmacol. 2009; 49: 196–204. Citing Literature Volume53, Issue5October 2011Pages 761-763 ReferencesRelatedInformation
Publication Year: 2011
Publication Date: 2011-09-28
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 16
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