Title: Effect of Fasting on Insulin Secretion and Action in Mice
Abstract: Studies in fed and 24 hr fasted mice have shown that fasting causes a resistance to the hypoglycemic action of both sulfonylurea drugs and exogenous insulin. Following the iv administration of tolbutamide to fed mice, there is a moderate elevation of plasma insulin over basal levels. This results in a significant decline in blood glucose. In contrast, after the administration of tolbutamide to 24 hr fasted mice there is no significant fall in blood glucose, despite a greater plasma insulin elevation than that noted in the fed mice. Intravenous insulin tolerance tests in such animals demonstrate that this altered response in the fasting state is at least partially due to decreased insulin sensitivity. The resistance to insulin and tolbutamide action occurring in fasting was abolished by adrenalectomy and was not restored by either physiological (0.15 mg/day) or supraphysiological (0.30 mg/ day) cortisol replacement. The data suggest that the insulin resistance due to fasting may be mediated by adrenal medullary hormones. (Endocrinology86: 313, 1970)
Publication Year: 1970
Publication Date: 1970-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 21
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