Title: Gamma knife radiosurgery for vestibular schwannomas: Identification of predictors for continued tumor growth and the influence of documented tumor growth preceding radiation treatment
Abstract: The LaryngoscopeVolume 121, Issue 9 p. 1834-1838 Cranial Base Gamma knife radiosurgery for vestibular schwannomas: Identification of predictors for continued tumor growth and the influence of documented tumor growth preceding radiation treatment† Ferdinand C. A. Timmer MD, Corresponding Author Ferdinand C. A. Timmer MD [email protected] the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsRadboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Otorhinolaryngology–Head and Neck Surgery, PO Box 9101 6500 HB Nijmegen, The NetherlandsSearch for more papers by this authorJef J. S. Mulder MD, PhD, Jef J. S. Mulder MD, PhD the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorPatrick E. J. Hanssens MD, Patrick E. J. Hanssens MD the Gamma Knife Center Tilburg, St. Elisabeth Hospital, Tilburg, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorJ. J. van Overbeeke MD, PhD, J. J. van Overbeeke MD, PhD the Gamma Knife Center Tilburg, St. Elisabeth Hospital, Tilburg, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorRogier T. Donders, Rogier T. Donders Department of Epidemiology, Biostatistics and HTA, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorCor W. R. J. Cremers MD, PhD, Cor W. R. J. Cremers MD, PhD the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorKees Graamans MD, PhD, Kees Graamans MD, PhD the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this author Ferdinand C. A. Timmer MD, Corresponding Author Ferdinand C. A. Timmer MD [email protected] the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsRadboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Otorhinolaryngology–Head and Neck Surgery, PO Box 9101 6500 HB Nijmegen, The NetherlandsSearch for more papers by this authorJef J. S. Mulder MD, PhD, Jef J. S. Mulder MD, PhD the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorPatrick E. J. Hanssens MD, Patrick E. J. Hanssens MD the Gamma Knife Center Tilburg, St. Elisabeth Hospital, Tilburg, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorJ. J. van Overbeeke MD, PhD, J. J. van Overbeeke MD, PhD the Gamma Knife Center Tilburg, St. Elisabeth Hospital, Tilburg, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorRogier T. Donders, Rogier T. Donders Department of Epidemiology, Biostatistics and HTA, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorCor W. R. J. Cremers MD, PhD, Cor W. R. J. Cremers MD, PhD the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this authorKees Graamans MD, PhD, Kees Graamans MD, PhD the Department of Otorhinolaryngology–Head and Neck Surgery, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands and the Department of Neurosurgery, Maastricht Medical Center, Maastricht, The NetherlandsSearch for more papers by this author First published: 16 August 2011 https://doi.org/10.1002/lary.21908Citations: 15 † The authors have no funding, financial relationships, or conflicts of interest to disclose. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Objectives/Hypothesis: Gamma knife radiosurgery (GKRS) has become an important treatment modality for vestibular schwannomas. The primary aim of this study was to investigate whether tumor growth at the moment of GKRS has any correlation with the outcome. The secondary aim was to identify clinical predictors of radioresistance in vestibular schwannoma patients treated with GKRS. Study Design: One hundred vestibular schwannoma patients, treated with GKRS, were divided into two groups: 1) proven tumor growth preceding GKRS; and 2) previous history of growth unknown. GKRS outcome was defined in two ways. According to the first definition, GKRS was said to have failed when additional treatment had taken place. According to the second one, a volume decrease >20% after 2 years marked successful treatment. Methods: Correlations between outcome and growth status were determined with SPSS software. Furthermore, the study assessed how different variables (patient data, history, tumor characteristics, imaging, and audiovestibular examinations) correlated with the outcome of GKRS. Results: No significant difference regarding success and failure of GKRS was found between the two patient groups. The mean reduction in tumor volume after GKRS was less pronounced in patients in whom tumor growth was demonstrated before treatment, but this finding was not significant. No significant predictors (P < .05) could be identified in this data set. Conclusions: This study found no indication that growth at the moment of GKRS influences therapeutic outcome, nor did it identify any predictors of the outcome after GKRS in vestibular schwannoma patients. Citing Literature Volume121, Issue9September 2011Pages 1834-1838 RelatedInformation
Publication Year: 2011
Publication Date: 2011-08-16
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 19
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