NARC-1/PCSK9 and Its Natural Mutants

Name: Work Video:
Duration: 3 min 30 s
Suzanne Benjannet; David Rhainds; Rachid Essalmani; Janice Mayne; L. Alexandra Wickham; Weijun Jin; Marie‐Claude Asselin; Josée Hamelin; Mathilde Varret; Delphine Allard; Mélanie Trillard; Marianne Abifadel; Angie Tebon; Alan Attie; Daniel J. Rader; Cathérine Boileau; Louise Brissette; Michel Chrètien; Annik Prat; Nabil G. Seidah
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2725, 2781, 2834, 2856, 3135, 3192, 3589, 3603, 3808, 3901, 4016, 4022, 4153, 4271, 4303], 'role': [25, 233, 4273], 'low': [27, 235, 789, 1336], 'density': [28, 236, 790, 848, 1337], 'lipoprotein': [29, 237, 1338], '(LDL)': [30, 238, 1339], 'metabolism.': [31, 239], 'We': [32, 240, 937, 1001, 2148], 'show': [33, 241, 2150, 2171], 'that': [34, 46, 142, 197, 242, 254, 350, 405, 617, 691, 944, 955, 1004, 1342, 1746, 1764, 1836, 1910, 2000, 2110, 2151, 2172, 2194, 2233, 2242, 4042, 4248, 4282, 4301, 4507], 'endoplasmic': [36, 244, 782, 1995], 'reticulum-localized': [37, 245], 'proNARC-1': [38, 246, 1989], 'to': [39, 189, 247, 397, 428, 630, 1385, 1607, 1692, 1743, 1761, 1768, 1895, 1905, 1977, 2108, 2143, 2251, 2320, 2839, 3585, 3709, 3768, 3791, 3884, 3951, 3978, 4357, 4410, 4452], 'NARC-1': [40, 122, 145, 159, 187, 248, 330, 353, 367, 395, 760, 869, 962, 1007, 1019, 1150, 1577, 1603, 1765, 1837, 1866, 1969, 1999, 2046, 2124, 2153, 2178, 2234, 2247, 2270, 2345, 3479, 3539, 3678, 3843, 3858, 3892, 3994, 4300, 4401, 4471, 4482], 'zymogen': [41, 49, 75, 93, 249, 257, 283, 301, 1988, 2095, 2125, 2167, 4276], 'conversion': [42, 250], 'is': [43, 131, 251, 339, 753, 946, 1321, 1330, 1343, 1545, 1586, 1766, 1912, 1990, 2001, 2048, 2163, 4511], 'Ca2+-independent': [44, 252], 'and': [45, 57, 65, 71, 86, 128, 196, 205, 253, 265, 273, 279, 294, 336, 404, 413, 486, 569, 633, 718, 886, 941, 951, 954, 1022, 1025, 1032, 1149, 1259, 1502, 1565, 1594, 1620, 1700, 1759, 1970, 1981, 2099, 2116, 2133, 2203, 2268, 2271, 2346, 2351, 2365, 2392, 2407, 2422, 2438, 2584, 2596, 2651, 2657, 2682, 2738, 2780, 2813, 2861, 2881, 2894, 2896, 2926, 2970, 2972, 3014, 3032, 3037, 3051, 3076, 3130, 3210, 3228, 3243, 3262, 3357, 3398, 3442, 3466, 3474, 3557, 3619, 3695, 3707, 3723, 3753, 3772, 3823, 3866, 3875, 3947, 3999, 4020, 4033, 4109, 4120, 4146, 4280, 4408, 4491], 'within': [47, 255], 'autocatalytic': [50, 258, 966], 'processing': [51, 259, 967, 2096, 4277, 4456], 'site': [52, 260, 4354, 4361, 4457, 4510], 'SSVFAQ↓SIP': [53, 261], 'Val': [54, 262], 'at': [55, 59, 263, 267, 491, 2186, 2717, 3183, 3322, 3406, 3606, 3641, 3665, 3704, 3718, 3729, 3770, 4105, 4125, 4136, 4305, 4338, 4500, 4525], 'P4': [56, 264], 'Pro': [58, 266], 'P3′': [60, 268], 'are': [61, 102, 114, 269, 310, 322, 606, 747, 1043, 1225, 1551, 1605, 1747, 1840, 1902], 'critical.': [62, 270], 'S127R': [64, 109, 272, 317, 1393, 2115, 2177, 2768], 'D374Y': [66, 274, 1466, 1528, 2118, 2136, 2352], 'result': [68, 276, 1580], '∼50–60%': [70, 278], '≥98%': [72, 280], 'decrease': [73, 281], 'processing,': [76, 284, 2126], 'respectively.': [77, 285], 'In': [78, 185, 286, 393, 1518, 1556, 1893, 2087, 3990], 'contrast,': [79, 287], 'double': [81, 289, 1526, 2135], '[D374Y': [82, 290], '+': [83, 291, 1529, 2137, 3658, 3737, 3785], 'N157K],': [84, 292], 'F216L,': [85, 293, 2129], 'R218S': [87, 295], 'natural': [88, 125, 296, 333, 2113], 'mutants': [89, 297, 2273, 2348], 'resulted': [90, 162, 298, 370], 'normal': [92, 300], 'processing.': [94, 302, 2168], 'cell': [96, 304, 629, 631, 810, 2359, 3297], 'surface': [97, 305, 2188], 'LDL': [98, 170, 181, 306, 378, 389, 793, 1566, 1701, 1982, 2236, 2259, 3049, 3104, 3129, 3168, 3294, 3961, 3980], 'receptor': [99, 307], '(LDLR)': [100, 308], 'levels': [101, 113, 309, 321, 1341, 1561, 1703, 1839, 1899, 1980, 2183, 3969, 4030, 4047, 4148, 4165], 'reduced': [103, 116, 311, 324], 'by': [104, 312, 883, 1332, 1749, 1846, 1857, 2676, 2730, 2854, 2886, 3007, 3088, 3134, 3381, 3425, 3461, 3548, 3600, 3625, 3799, 3896, 3899, 3959, 4063, 4168, 4185, 4402, 4460], '35%': [105, 313, 2181], 'lymphoblasts': [107, 315, 2746, 2799], 'patients.': [110, 318], 'LDLR': [112, 195, 320, 403, 1350, 2185, 2668, 2790, 2895, 3011, 3957, 3967], 'also': [115, 323, 2149, 4291], 'stable': [118, 326, 3542, 3673, 3879], 'HepG2': [119, 327, 1844, 2198, 2361, 2687, 3311, 3543, 3674, 3846, 3880, 4476], 'cells': [120, 328, 1845, 2199, 2370, 2403, 2419, 2563, 2688, 2950, 3174, 3216, 3313, 3345, 3400, 3428, 3447, 3984], 'overexpressing': [121, 329, 2200], 'or': [123, 331, 1351, 1394, 1751, 2433, 2441, 2454, 2467, 2694, 2774, 2918, 3169, 3679, 3686, 4475], 'its': [124, 332, 965, 1026, 1039, 2007, 2159, 2272, 2347], 'mutant': [126, 334, 1465], 'S127R,': [127, 335, 2350], 'this': [129, 337, 939, 1592, 2088, 2146, 2201, 4314], 'reduction': [130, 338], 'abrogated': [132, 340, 964], 'presence': [135, 343, 2207, 2455, 2693, 3687, 4522], '5': [137, 345, 2697, 3689], 'mm': [138, 346, 2571, 2574, 2698, 3066, 3069, 3354, 3359, 3757], 'ammonium': [139, 347], 'chloride,': [140, 348], 'suggesting': [141, 349], 'overexpression': [143, 351, 1005], 'increases': [146, 354], 'turnover': [148, 356], 'rate': [149, 357], 'LDLR.': [152, 360, 2266], 'Adenoviral': [153, 361], 'expression': [154, 362, 1017, 1028, 2244], 'wild': [156, 364, 851, 2343], 'type': [157, 365, 2344, 3997], 'human': [158, 366, 785, 2112, 2246, 2357, 2667, 3857, 3891, 4470], 'mice': [161, 175, 369, 383, 2249, 4002, 4035], 'maximal': [165, 373], '∼9-fold': [166, 374], 'increase': [167, 179, 375, 387, 1334, 2256], 'circulating': [169, 199, 377, 407, 1560, 2258], 'cholesterol,': [171, 379, 1906, 4144], 'while': [172, 380], 'LDLR(–/–)': [174, 382, 4000], 'delayed': [177, 385], '∼2-fold': [178, 386], 'cholesterol': [182, 390, 1340, 1564, 1567, 1699, 1702, 1750, 1979, 2260, 4029, 4046, 4164, 4220], 'was': [183, 391, 870, 890, 2195, 2324, 2722, 2852, 2975, 3045, 3062, 3086, 3162, 3266, 3289, 3341, 3412, 3423, 3435, 3481, 3545, 3582, 3617, 3650, 3766, 3789, 3797, 3894, 4073, 4099, 4122, 4290, 4316, 4335, 4405], 'observed.': [184, 392], 'conclusion,': [186, 394], 'seems': [188, 396], 'affect': [190, 398, 1598, 2145], 'both': [191, 399, 1549], 'level': [193, 401, 3889, 3955], 'apoB-containing': [200, 408], 'lipoproteins': [201, 409], 'an': [203, 411, 1333, 3033, 3469, 3527, 3818, 4229, 4498], 'LDLR-dependent': [204, 412], '-independent': [206, 414], 'fashion.': [207, 415], 'mammalian': [417], 'convertases': [419, 438, 1062], 'constitute': [420], 'family': [422], '9': [424, 1622], 'serine': [425], 'proteinases': [426], 'related': [427], 'bacterial': [429], 'subtilisin.': [430], 'These': [431, 604, 3868, 4503], 'include': [432], '7': [434], 'basic': [435], 'amino': [436, 1377, 2663, 4345], 'acid-specific': [437], 'known': [439, 754, 1587], 'as': [440, 2003, 2284, 2474, 2930, 3047, 3090, 3111, 3291, 3483, 3907, 4195, 4489], 'PC1/PC3,': [441], 'PC2,': [442], 'furin,': [443], 'PC4,': [444], 'PACE4,': [445], 'PC5/PC6,': [446], 'PC7/LPS': [447], '(1Seidah': [448], 'N.G.': [449, 496, 572, 637, 969, 1202, 1451, 1677, 1876, 2011, 2055, 2220, 2287, 2382, 2478, 2545, 2625, 3509, 3910, 4365, 4416], 'Chretien': [450, 521, 587, 984, 2026, 2070, 2302, 2503, 2542, 2622, 3506, 3925, 4380, 4431], 'M.': [451, 514, 522, 524, 588, 985, 1154, 1156, 1164, 1178, 1198, 1403, 1405, 1413, 1427, 1447, 1629, 1631, 1639, 1653, 1673, 2027, 2071, 2303, 2372, 2496, 2504, 2506, 2529, 2543, 2609, 2623, 2984, 2986, 2988, 3493, 3507, 3926, 4381, 4432], 'Brain': [452], 'Res.': [453, 1815, 3096], '1999;': [454, 473, 532, 1960, 2514], '848:': [455], '45-62Crossref': [456], 'PubMed': [457, 481, 535, 564, 599, 645, 660, 685, 742, 932, 996, 1089, 1144, 1210, 1254, 1312, 1365, 1459, 1497, 1513, 1538, 1685, 1732, 1798, 1824, 1888, 1944, 1963, 2038, 2082, 2226, 2314, 2388, 2517, 2557, 2637, 2944, 2998, 3100, 3124, 3149, 3285, 3375, 3521, 3937, 4214, 4392, 4443], 'Scopus': [458, 482, 536, 565, 600, 646, 661, 686, 743, 933, 997, 1090, 1145, 1211, 1255, 1313, 1366, 1460, 1498, 1514, 1539, 1686, 1733, 1799, 1825, 1889, 1945, 1964, 2039, 2083, 2227, 2315, 2518, 2558, 2638, 2945, 3125, 3150, 3376, 3522, 3938, 4215, 4393, 4444], '(692)': [459], 'Google': [460, 484, 538, 567, 602, 648, 663, 688, 716, 745, 935, 999, 1092, 1147, 1213, 1257, 1315, 1368, 1462, 1500, 1516, 1541, 1688, 1735, 1801, 1827, 1891, 1947, 1966, 2041, 2085, 2229, 2317, 2389, 2520, 2560, 2640, 2758, 2947, 2999, 3101, 3127, 3152, 3286, 3378, 3524, 3940, 4217, 4395, 4446], 'Scholar,': [461, 539, 649, 1093, 1802, 1948, 2521], '2Zhou': [462], 'A.': [463, 508, 531, 584, 586, 595, 639, 738, 923, 981, 983, 992, 1103, 1123, 1174, 1196, 1271, 1291, 1423, 1445, 1649, 1671, 1794, 1870, 1880, 1928, 1959, 2023, 2025, 2034, 2067, 2069, 2078, 2216, 2299, 2301, 2310, 2374, 2490, 2513, 2525, 2533, 2605, 2613, 2978, 3489, 3497, 3922, 3924, 3933, 4377, 4379, 4388, 4428, 4430, 4439], 'Webb': [464], 'G.': [465, 651, 1190, 1439, 1665, 1868], 'Zhu': [466], 'X.': [467, 1119, 1287], 'Steiner': [468], 'D.F.': [469], 'J.': [470, 500, 512, 541, 578, 681, 721, 975, 1138, 1184, 1194, 1306, 1356, 1359, 1433, 1443, 1659, 1669, 1726, 1813, 1874, 1926, 1933, 2017, 2061, 2222, 2293, 2329, 2378, 2384, 2482, 2494, 2546, 2626, 2752, 2989, 3120, 3143, 3276, 3369, 3510, 3916, 4208, 4371, 4422], 'Biol.': [471, 656, 1884, 1934, 2547, 2627, 2990, 3277, 3371, 3511], 'Chem.': [472, 1935, 2548, 2628, 2991, 3278, 3512], '274:': [474], '20745-20748Abstract': [475], 'Full': [476, 478, 559, 561, 1819, 1821, 1939, 1941, 2552, 2554, 2632, 2634, 2995, 3282, 3516, 3518], 'Text': [477, 479, 560, 562, 1820, 1822, 1940, 1942, 2553, 2555, 2633, 2635, 2996, 3283, 3517, 3519], 'PDF': [480, 563, 1823, 1943, 2556, 2636, 2997, 3284, 3520], '(413)': [483], 'Scholar)': [485, 568, 689, 717, 746, 1148, 1258, 1689, 2759, 3153, 3525], 'two': [488, 1058, 1738, 4039, 4461], 'enzymes': [489], 'cleaving': [490], 'nonbasic': [492], 'residues': [493, 4251, 4488], 'SKI-1/S1P': [494, 719], '(3Seidah': [495, 2477], 'Mowla': [497, 2479], 'S.J.': [498, 1129, 1297, 2480], 'Hamelin': [499, 2481], 'Mamarbachi': [501, 2483, 2528, 2608, 3492], 'A.M.': [502, 2484], 'Benjannet': [503, 573, 970, 1167, 1416, 1642, 2012, 2056, 2288, 2485, 3911, 4366, 4417], 'S.': [504, 530, 574, 582, 594, 737, 899, 971, 979, 991, 1073, 1083, 1137, 1168, 1238, 1248, 1305, 1417, 1475, 1483, 1643, 1719, 1793, 1958, 2013, 2021, 2033, 2057, 2065, 2077, 2289, 2297, 2309, 2486, 2512, 2523, 2539, 2603, 2619, 3487, 3503, 3912, 3920, 3932, 4367, 4375, 4387, 4418, 4426, 4438], 'Toure': [505, 2487], 'B.B.': [506, 2488], 'Basak': [507, 583, 980, 2022, 2066, 2215, 2298, 2489, 2532, 2612, 3496, 3921, 4376, 4427], 'Munzer': [509, 2491, 2530, 2610, 3494], 'J.S.': [510, 917, 2376, 2492, 2531, 2611, 3495, 4201], 'Marcinkiewicz': [511, 523, 577, 974, 2016, 2060, 2292, 2493, 2505, 3915, 4370, 4421], 'Zhong': [513, 2495], 'Barale': [515, 2497], 'J.C.': [516, 1081, 1121, 1246, 1289, 2380, 2498], 'Lazure': [517, 2499, 2534, 2614, 3498], 'C.': [518, 1166, 1200, 1204, 1415, 1449, 1453, 1641, 1675, 1679, 2500, 2535, 2615, 3499], 'Murphy': [519, 2501], 'R.A.': [520, 2502], 'Proc.': [525, 589, 732, 986, 1788, 1953, 2028, 2072, 2304, 2507, 3927, 4382, 4433], 'Natl.': [526, 590, 733, 987, 1789, 1954, 2029, 2073, 2305, 2508, 3928, 4383, 4434], 'Acad.': [527, 591, 734, 988, 1790, 1955, 2030, 2074, 2306, 2509, 3929, 4384, 4435], 'Sci.': [528, 592, 735, 989, 1791, 1956, 2031, 2075, 2307, 2510, 3930, 4385, 4436], 'U.': [529, 593, 736, 905, 990, 1792, 1957, 2032, 2076, 2308, 2511, 3931, 4203, 4386, 4437], '96:': [533, 1961, 2515], '1321-1326Crossref': [534, 2516], '(249)': [537, 2519], '4Sakai': [540], 'Rawson': [542], 'R.B.': [543], 'Espenshade': [544], 'P.J.': [545, 1133, 1301], 'Cheng': [546], 'D.': [547, 1115, 1160, 1172, 1283, 1409, 1421, 1635, 1647], 'Seegmiller': [548], 'A.C.': [549], 'Goldstein': [550, 722, 1786, 1929, 1951], 'J.L.': [551, 723, 1787, 1812, 1930, 1952, 2934], 'Brown': [552, 728, 1784, 1931, 2937], 'M.S.': [553, 729, 1785, 1932, 1950, 2938], 'Mol.': [554, 654], 'Cell.': [555, 655], '1998;': [556, 713, 1936], '2:': [557], '505-514Abstract': [558], '(328)': [566], 'NARC-1/PCSK9': [570], '(5Seidah': [571, 968, 2010, 2054, 2286, 3909, 4364, 4415], 'Wickham': [575, 972, 1169, 1418, 1644, 2014, 2058, 2290, 2526, 2606, 3490, 3913, 4368, 4419], 'L.': [576, 697, 901, 973, 1077, 1170, 1176, 1242, 1419, 1425, 1645, 1651, 1878, 2015, 2059, 2291, 2527, 2607, 3114, 3118, 3491, 3914, 4369, 4420], 'Jasmin': [579, 976, 2018, 2062, 2294, 3917, 4372, 4423], 'S.B.': [580, 977, 2019, 2063, 2295, 3918, 4373, 4424], 'Stifani': [581, 978, 2020, 2064, 2296, 3919, 4374, 4425], 'Prat': [585, 638, 982, 1195, 1444, 1670, 1879, 2024, 2068, 2300, 2373, 3923, 4378, 4429], '2003;': [596, 682, 929, 993, 1141, 1207, 1309, 1362, 1456, 1682, 1795, 1816, 2035, 2079, 2223, 2311, 2385, 3934, 4211, 4389, 4440], '100:': [597, 994, 1796, 2036, 2080, 2312, 3935, 4390, 4441], '928-933Crossref': [598, 995, 2037, 2081, 2313, 3936, 4391, 4442], '(934)': [601, 998, 2040, 2084, 2316, 3939, 4394, 4445], 'Scholar).': [603, 664, 936, 1000, 1214, 1316, 1369, 1517, 1736, 1828, 1892, 1967, 2042, 2086, 2230, 2318, 2390, 2561, 2641, 3000, 3102, 3128, 3287, 3941, 4218, 4396, 4447], 'proteases': [605], 'implicated': [607, 1770], 'limited': [610], 'proteolysis': [611], 'precursors': [613], 'secretory': [615], 'proteins': [616, 1757, 1923, 3004], 'regulate': [618], 'variety': [620], 'cellular': [622, 625, 2702], 'functions,': [623], 'including': [624], 'growth,': [626], 'adhesion,': [627], 'differentiation,': [628], 'communications,': [632], 'endocrine/paracrine': [634], 'functions': [635], '(6Seidah': [636], 'Essays': [640], 'Biochem.': [641, 927, 2221, 2383, 3119], '2002;': [642, 657], '38:': [643], '79-94Crossref': [644], '(188)': [647], '7Thomas': [650], 'Nat.': [652, 1084, 1205, 1249, 1454, 1680], 'Rev.': [653], '3:': [658], '753-766Crossref': [659], '(952)': [662], 'Published': [665], 'gene': [666, 1578, 1627, 2773], 'knockout': [667, 861], 'analyses': [668, 4060], '(reviewed': [669], 'Ref.': [671, 2932], '8Taylor': [672], 'N.A.': [673, 1777], 'Van': [674, 705], 'de': [675, 706], 'Ven': [676, 707], 'W.J.': [677, 708], 'Creemers': [678, 1070, 1096, 1235, 1264], 'J.W.': [679, 1071, 1097, 1236, 1265], 'FASEB': [680], '17:': [683], '1215-1227Crossref': [684], '(192)': [687, 744], 'revealed': [690, 3038, 4497], 'only': [692, 1056], 'furin': [693], '(9Roebroek': [694], 'A.J.': [695], 'Umans': [696], 'Pauli': [698], 'I.G.': [699], 'Robertson': [700], 'E.J.': [701], 'van': [702], 'Leuven': [703], 'F.': [704, 2541, 2621, 3505], 'Constam': [709], 'D.B.': [710], 'Development': [711], '(Camb.).': [712], '125:': [714], '4863-4876PubMed': [715], '(10Yang': [720], 'Hammer': [724], 'R.E.': [725, 1806], 'Moon': [726], 'Y.A.': [727], 'Horton': [730], 'J.D.': [731, 919, 1775], '2001;': [739, 2549, 2629, 3513], '98:': [740, 2942], '13607-13612Crossref': [741], 'embryonic': [748, 786], 'lethal.': [749], 'So': [750], 'far,': [751], 'nothing': [752, 1585], 'about': [755, 1588], 'phenotype': [757], 'consequences': [758], '1The': [761], 'abbreviations': [762], 'used': [763, 1740, 2644, 3883, 3950], 'are:': [764], 'neural': [766, 881], 'apoptosis': [767, 882, 893], 'regulated': [768, 894, 1748, 1975], '1;': [770, 807], 'apoB,': [771], 'apolipoprotein': [772], 'B;': [773], 'ADH,': [774], 'hypercholesterolemia;': [777], 'HCHOLA3,': [778], 'third': [779, 1387], 'locus;': [780], 'ER,': [781], 'reticulum;': [783], 'HEK,': [784], 'kidney;': [787], 'LDL,': [788], 'lipoprotein;': [791, 849], 'LDLR,': [792], 'receptor;': [794], 'PC,': [795], 'convertase;': [797], 'SREBP,': [798], 'sterol': [799, 1753, 1920], 'regulatory': [800, 1754, 1921], 'element': [801, 1755], 'binding': [802, 1756], 'protein;': [803], 'SKI-1,': [804], 'subtilisin-kexin': [805], 'isozyme': [806], 'FACS,': [808], 'fluorescence-activated': [809], 'sorter;': [811], 'mAb,': [812], 'monoclonal': [813, 2647], 'antibody;': [814], 'Tricine,': [815], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine;': [816], 'EBV,': [817], 'Epstein-Barr': [818], 'virus;': [819], 'MEM,': [820], 'minimum': [821], "Eagle's": [822, 2805], 'medium;': [823], 'BSA,': [824], 'bovine': [825, 2913], 'serum': [826, 884, 2811, 2914, 2921, 4028], 'albumin;': [827], 'PBS,': [828, 3579], 'phosphate-buffered': [829], 'saline;': [830], 'RT,': [831, 3771], 'room': [832, 3607, 3642, 3666], 'temperature;': [833], 'SELDI-TOF-MS,': [834], 'surface-enhanced': [835, 3800], 'laser': [836, 3801], 'desorption': [837, 3802], 'time-of-flight': [838, 3563, 3803], 'mass': [839, 3564, 3804, 4324], 'spectrometry;': [840], 'FPLC,': [841], 'fast': [842], 'protein': [843, 889, 3264, 3480, 3576, 3614, 3713, 4496], 'liquid': [844], 'chromatography;': [845], 'HDL,': [846], 'high': [847], 'WT,': [850], 'type;': [852], 'RP,': [853], 'relative': [854, 3954, 3966], 'processing;': [855], 'EGFP,': [856], 'enhanced': [857], 'green': [858], 'fluorescent': [859, 2369, 3960], 'protein.': [860, 3298], 'mice.': [863, 4058], 'cDNA': [865, 3859, 3902], 'enzyme': [868], 'cloned': [871, 2276, 3870], 'during': [872, 3437], 'pharmaceutical': [873], 'screening': [874], 'mRNAs': [876, 1745], 'up-regulated': [877, 1841], 'following': [878, 2362, 3862], 'induction': [879], 'withdrawal,': [885], 'encoded': [888], 'called': [891], '"neural': [892], '1"': [896], '(NARC-1)': [897], '(11Naureckiene': [898], 'Ma': [900], 'Sreekumar': [902], 'K.': [903, 1127, 1162, 1295, 1411, 1479, 1637, 1711], 'Purandare': [904], 'Lo': [906], 'C.F.': [907], 'Huang': [908], 'Y.': [909, 1715, 1721], 'Chiang': [910], 'L.W.': [911], 'Grenier': [912], 'J.M.': [913, 1188, 1437, 1663, 4205], 'Ozenberger': [914], 'B.A.': [915], 'Jacobsen': [916], 'Kennedy': [918], 'DiStefano': [920], 'P.S.': [921], 'Wood': [922], 'Bingham': [924], 'B.': [925, 1186, 1435, 1661], 'Arch.': [926], 'Biophys.': [928], '420:': [930], '55-67Crossref': [931], '(138)': [934], 'characterized': [938, 1331], 'enzyme,': [940], 'we': [942, 2090, 2170, 4449, 4465], 'showed': [943, 1003, 4302], 'it': [945, 1544, 1911], 'highly': [947], 'expressed': [948], 'liver': [950, 1021], 'small': [952, 1023, 3016], 'intestine': [953, 1024], 'specific': [956, 3160], 'prosegment': [960, 2009], 'completely': [963], 'further': [1002], 'enhances': [1008], 'neurogenesis': [1009], 'progenitor': [1011], 'brain': [1012], 'telencephalic': [1013], 'cells.': [1014, 4477], 'sustained': [1016], 'transient': [1027], 'telencephalon,': [1030], 'kidney,': [1031], 'cerebellum': [1033], 'beg': [1034], 'for': [1035, 1057, 1227, 1325, 2165, 2425, 2600, 2762, 2766, 2784, 2824, 2844, 2904, 2954, 3180, 3319, 3403, 3610, 3638, 3662, 3692, 3701, 3715, 3741, 3750, 3761], 'identification': [1037], 'physiological': [1040], 'substrates,': [1041], 'which': [1042, 1329, 2593, 3085], 'still': [1044], 'unknown.': [1045], 'Human': [1046, 3103], 'genetic': [1047], 'point': [1048, 1372], 'pathology': [1052], 'have': [1053, 2091, 4450], 'been': [1054], 'reported': [1055, 4246], '(PCs),': [1063], 'namely': [1064], 'PC1': [1065], '(gene': [1066, 1151], 'PCSK1)': [1067], '(12Jackson': [1068, 1233], 'R.S.': [1069, 1095, 1234, 1263], 'Ohagi': [1072, 1237], 'Raffin-Sanson': [1074, 1100, 1239, 1268], 'M.L.': [1075, 1101, 1240, 1269], 'Sanders': [1076, 1241], 'Montague': [1078, 1243], 'C.T.': [1079, 1244], 'Hutton': [1080, 1120, 1245, 1288], "O'Rahilly": [1082, 1136, 1247, 1304], 'Genet.': [1085, 1206, 1250, 1455, 1493, 1509, 1534, 1681, 1728, 2754], '1997;': [1086, 1251], '16:': [1087, 1252], '303-306Crossref': [1088, 1253], '(939)': [1091, 1256], '13Jackson': [1094], 'Farooqi': [1098, 1266], 'I.S.': [1099, 1267, 3368], 'Varro': [1102, 1270], 'Dockray': [1104, 1272], 'G.J.': [1105, 1273], 'Holst': [1106, 1274], 'J.J.': [1107, 1275], 'Brubaker': [1108, 1276], 'P.L.': [1109, 1277], 'Corvol': [1110, 1278], 'P.': [1111, 1192, 1279, 1441, 1667], 'Polonsky': [1112, 1280], 'K.S.': [1113, 1281], 'Ostrega': [1114, 1282], 'Becker': [1116, 1284], 'K.L.': [1117, 1285], 'Bertagna': [1118, 1286], 'White': [1122, 1290], 'Dattani': [1124, 1292], 'M.T.': [1125, 1293], 'Hussain': [1126, 1294], 'Middleton': [1128, 1296], 'Nicole': [1130, 1298], 'T.M.': [1131, 1299], 'Milla': [1132, 1300], 'Lindley': [1134, 1302], 'K.J.': [1135, 1303], 'Clin.': [1139, 1307, 1360, 1508, 1533, 3144, 4209], 'Investig.': [1140, 1308, 1361, 3145, 4210], '112:': [1142, 1310], '1550-1560Crossref': [1143, 1311], '(303)': [1146, 1314], 'PCSK9)': [1152], '(14Abifadel': [1153, 1402, 1628], 'Varret': [1155, 1404, 1630], 'Rabes': [1157, 1406, 1632], 'J.P.': [1158, 1407, 1633], 'Allard': [1159, 1408, 1634], 'Ouguerram': [1161, 1410, 1636], 'Devillers': [1163, 1412, 1638], 'Cruaud': [1165, 1414, 1640], 'Erlich': [1171, 1420, 1646], 'Derre': [1173, 1422, 1648], 'Villeger': [1175, 1424, 1650], 'Farnier': [1177, 1426, 1652], 'Beucler': [1179, 1428, 1654], 'I.': [1180, 1429, 1655], 'Bruckert': [1181, 1430, 1656], 'E.': [1182, 1431, 1657, 1810, 2214, 2218], 'Chambaz': [1183, 1432, 1658], 'Chanu': [1185, 1434, 1660], 'Lecerf': [1187, 1436, 1662], 'Luc': [1189, 1438, 1664], 'Moulin': [1191, 1440, 1666], 'Weissenbach': [1193, 1442, 1668], 'Krempf': [1197, 1446, 1672], 'Junien': [1199, 1448, 1674], 'Seidah': [1201, 1450, 1676, 1875, 2219, 2381, 2544, 2624, 3508], 'Boileau': [1203, 1452, 1678], '34:': [1208, 1457, 1683], '154-156Crossref': [1209, 1458, 1684], '(2222)': [1212, 1461, 1687], 'Two': [1215, 2415], 'distinct': [1216], 'mutations,': [1218], 'one': [1219, 1522, 3382, 3731], 'on': [1220, 1552, 2093, 2678, 2724, 2827, 2847, 2968, 3363, 3468, 3526, 4015, 4092, 4152, 4189, 4293, 4328], 'each': [1221, 1382, 2874, 3792, 4026, 4181], 'allele': [1222], 'PCSK1,': [1224], 'responsible': [1226], 'recessive': [1229], 'form': [1230, 1388], 'obesity': [1232], 'endocrine': [1260], 'malfunctions': [1261], '(13Jackson': [1262], 'Autosomal': [1317], 'hypercholesterolemia': [1319], '(ADH)': [1320], 'risk': [1323], 'factor': [1324], 'coronary': [1326], 'heart': [1327], 'disease,': [1328], 'associated': [1344, 1695], 'genes': [1349], 'APOB': [1352], '(15Rader': [1353], 'D.J.': [1354, 4207], 'Cohen': [1355], 'Hobbs': [1357], 'H.H.': [1358], '111:': [1363, 4212], '1795-1803Crossref': [1364], '(479)': [1367], 'Three': [1370, 3942], 'single': [1371], 'causing': [1376], 'acid': [1378, 3356, 3778, 3788], 'changes': [1379], 'were': [1380, 1396, 1568, 1690, 2275, 2353, 2396, 2420, 2471, 2564, 2598, 2645, 2674, 2689, 2715, 2760, 2800, 2819, 2830, 2864, 2879, 2884, 2902, 2951, 3005, 3022, 3109, 3132, 3178, 3213, 3217, 3241, 3253, 3317, 3388, 3401, 3448, 3455, 3623, 3670, 3696, 3721, 3726, 3825, 3851, 3869, 3882, 3949, 3974, 4003, 4013, 4031, 4036, 4051, 4061, 4077, 4114, 4134, 4149, 4166, 4183, 4226], 'reported,': [1381], 'genetically': [1383], 'linked': [1384], 'ADH.': [1390], 'F216L': [1395], 'detected': [1397, 3436], 'different': [1399, 1985, 3854], 'French': [1400], 'families': [1401], 'Scholar),': [1463, 1501, 1542, 3379], 'large': [1469, 4467], 'Utah': [1470], 'pedigree': [1471], '(16Timms': [1472], 'K.M.': [1473], 'Wagner': [1474], 'Samuels': [1476], 'M.E.': [1477], 'Forbey': [1478], 'Goldfine': [1480], 'H.': [1481, 1723, 1872], 'Jammulapati': [1482], 'Skolnick': [1484], 'M.H.': [1485], 'Hopkins': [1486], 'P.N.': [1487], 'Hunt': [1488], 'S.C.': [1489], 'Shattuck': [1490], 'D.M.': [1491], 'Hum.': [1492, 1727, 2753], '2004;': [1494, 1510, 1535, 1729, 1885], '114:': [1495], '349-353Crossref': [1496], '(271)': [1499], 'Norwegian': [1504], 'subjects': [1505, 2763, 2776, 2793], '(17Leren': [1506, 1531], 'T.P.': [1507, 1532], '65:': [1511, 1536], '419-422Crossref': [1512, 1537], '(209)': [1515, 1540], 'latter': [1520], 'study,': [1521, 4027], 'patient': [1523], 'exhibited': [1524], 'mutation': [1527, 2179, 2769, 2787], 'N157K': [1530, 2131, 2138], 'although': [1543, 2152], 'not': [1546, 1903, 2141, 2155, 4052, 4317], 'clear': [1547], 'if': [1548, 4341], 'same': [1554, 4127], 'allele.': [1555], 'all': [1557, 2882], 'cases,': [1558], 'total': [1563, 1698, 2409, 3193, 4173], '2–6-fold': [1569], 'higher': [1570], 'than': [1571], 'normal.': [1572], 'Whereas': [1573], 'phenotype,': [1584], 'mechanism(s)': [1590], 'behind': [1591], 'effect': [1593], 'whether': [1595], 'such': [1596, 4041], 'enzymatic': [1600, 4230], 'activity': [1601, 3958, 3968], 'and/or': [1604], 'due': [1606], 'gain': [1609], 'nonenzymatic': [1611], 'function.': [1612], 'Recently,': [1613], 'common': [1615], 'polymorphic': [1616], 'intron': [1617], '1': [1618, 3231, 3611, 3702, 3762, 3773, 4085], '(C(–161)T)': [1619], 'exon': [1621], '(I474V)': [1623], 'variants': [1624], 'shown': [1691], 'be': [1693, 1769, 1855, 4411], 'significantly': [1694, 2144], 'increased': [1697], 'general': [1706], 'population': [1707], 'Japan': [1709], '(18Shioji': [1710], 'Mannami': [1712], 'T.': [1713, 2980, 2982, 3138], 'Kokubo': [1714], 'Inamoto': [1716], 'N.': [1717, 1725], 'Takagi': [1718], 'Goto': [1720], 'Nonogi': [1722], 'Iwai': [1724], '49:': [1730], '109-114Crossref': [1731], '(78)': [1734], 'Independently,': [1737], 'groups': [1739, 4040, 4050], 'microarray': [1741], 'technology': [1742], 'study': [1744], '(SREBPs),': [1758], 'came': [1760], 'conclusion': [1763], 'likely': [1767], 'sterol/lipid': [1772], 'metabolism': [1773, 1983], '(19Horton': [1774], 'Shah': [1776], 'Warrington': [1778], 'J.A.': [1779, 2537, 2617, 3501], 'Anderson': [1780], 'N.N.': [1781], 'Park': [1782], 'S.W.': [1783], '12027-12032Crossref': [1797], '(1097)': [1800], '20Maxwell': [1803], 'K.N.': [1804], 'Soccio': [1805], 'Duncan': [1807], 'E.M.': [1808], 'Sehayek': [1809], 'Breslow': [1811], 'Lipid': [1814, 3095], '44:': [1817], '2109-2119Abstract': [1818], '(310)': [1826], 'Furthermore,': [1829, 2169], 'recent': [1830], 'data': [1831, 2863, 4504], 'from': [1832, 2239, 3343, 3540, 3672, 4005, 4101, 4171, 4180, 4349, 4473], 'our': [1833], 'group': [1834, 4055], 'demonstrated': [1835], 'mRNA': [1838, 1898, 3844, 3893], 'hepatocyte-derived': [1843, 2358], 'hydroxymethylglutaryl-CoA': [1848], 'reductase': [1849], 'inhibitors': [1850, 2964], '"statins."': [1851], 'This': [1852, 2105, 4289], 'process': [1853], 'can': [1854], 'reversed': [1856, 2204], 'mevalonate': [1858, 2929], 'treatment,': [1859], 'implicating': [1860], 'SREBP-2': [1861], 'up-regulation': [1864], '(21Dubuc': [1867], 'Chamberland': [1869], 'Wassef': [1871], 'Davignon': [1873], 'Bernier': [1877], 'Arterioscler.': [1881], 'Thromb.': [1882], 'Vasc.': [1883], '24:': [1886], '1454-1459Crossref': [1887], '(526)': [1890], 'contrast': [1894], 'SKI-1': [1901, 1971], 'sensitive': [1904], 'despite': [1907], 'fact': [1909, 2241], 'key': [1914], 'protease': [1915, 2586, 2963], 'cleavage': [1918, 4268, 4353, 4519], 'element-binding': [1922], '(SREBPs)': [1924], '(22Sakai': [1925], 'Nohturfft': [1927], '273:': [1937], '5785-5793Abstract': [1938], '(191)': [1946], '23Brown': [1949], '11041-11048Crossref': [1962], '(1110)': [1965], 'Thus,': [1968, 4448], 'participate': [1972], 'response': [1976], 'intracellular': [1978], 'via': [1984, 4080], 'mechanisms.': [1986], 'autocatalytically': [1991], 'processed': [1992], 'reticulum': [1996], '(ER)': [1997], 'into': [1998, 3871, 4038], 'secreted': [2002, 3538, 4298, 4472, 4480], 'complex': [2005], '∼14-kDa': [2008], 'pro-form': [2044], '(pro-NARC-1)': [2047], 'found': [2049], 'predominantly': [2050], 'ER': [2053], 'report': [2089], 'focused': [2092], 'pro-NARC-1': [2098, 4279, 4459], 'secretion': [2101], 'mature': [2103], 'NARC-1.': [2104], 'led': [2106, 2250], 'us': [2107], 'demonstrate': [2109], 'especially': [2117], 'greatly': [2119], 'reduce': [2120], 'extent': [2122], 'whereas': [2127, 3417], 'R218S,': [2130], 'alone': [2132], 'do': [2140], 'seem': [2142], 'process.': [2147], 'does': [2154], 'contain': [2156], 'P-domain,': [2158], 'C-terminal': [2160, 2281], 'Cys/His-rich': [2161], 'domain': [2162], 'important': [2164], 'efficient': [2166], 'heterozygote': [2176, 2765, 2783], 'exhibit': [2180], 'lower': [2182], 'their': [2190, 2795], 'lymphoblasts,': [2191], 'finding': [2193], 'reproduced': [2196], 'mutant,': [2202], 'lysosomotrophic': [2210], 'agent': [2211], 'NH4Cl': [2212, 2699], '(24Bergeron': [2213], 'Decroly': [2217], '373:': [2224], '475-484Crossref': [2225], '(51)': [2228], 'Further': [2231], 'proof': [2232], 'regulates': [2235], 'production': [2237], 'comes': [2238], 'adenoviral': [2243], 'very': [2253, 4406], 'significant': [2254], 'time-dependent': [2255], 'even': [2261], 'absence': [2264, 2453, 2695, 3685], 'cDNAs': [2267, 2274], 'Cells—All': [2269], 'pIRES2-EGFP': [2278, 2340, 3680], 'V5': [2282], 'tag,': [2283], 'described': [2285, 2475, 3091, 3112, 3484, 3908, 4196], 'Antibody': [2319], 'LRP1': [2321, 2897, 3015], '(C-terminal': [2322], 'Ab377)': [2323], 'generous': [2326], 'gift': [2327], 'Herz': [2330], '(University': [2331], 'Texas,': [2333], 'Dallas).': [2334], 'Stable': [2335], 'transfectants': [2336, 3881], 'empty': [2338, 3987], 'bicistronic': [2339], 'vector,': [2341, 3681], 'V5-tagged': [2342, 3569, 3677], 'H226A,': [2349], 'obtained': [2354, 2761, 4004, 4100], 'line': [2360], 'G418': [2363], 'selection': [2364], 'FACS': [2366, 2739], 'purification': [2367], '(25Conesa': [2371], 'Mort': [2375], 'Marvaldi': [2377], 'Lissitzky': [2379], '370:': [2386], '703-711Crossref': [2387], 'Transfections': [2391], 'Biosynthetic': [2393], 'Analyses—All': [2394], 'transfections': [2395], 'done': [2397], '3': [2399, 3068, 3571], '×': [2400, 3164, 4086], '105': [2401, 3165], 'HEK293': [2402, 3446, 4474], 'using': [2404, 2731, 2855, 2866, 3039, 3900, 3963, 4160, 4228], 'Effectene': [2405], '(Qiagen)': [2406], '1–1.5': [2411], 'μg': [2412, 3188, 3292, 3327], 'cDNAs.': [2414], 'days': [2416], 'post-transfection,': [2417], 'washed': [2421, 3218, 3651, 3728], 'then': [2423, 2831], 'incubated': [2424, 2690, 2903, 2953, 3024, 3179, 3250, 3318, 3402], 'various': [2426, 4106], 'times': [2427, 3653, 3745, 4107, 4414], 'either': [2429, 2764, 2910], '250': [2430, 3199, 3331], 'μCi/ml': [2431, 2443, 3452], '[35S]Met/Cys': [2432], 'Na2[35SO4]': [2434], '(PerkinElmer': [2435], 'Life': [2436], 'Sciences': [2437], 'Analytical': [2439], 'Sciences)': [2440], '400': [2442, 3451], '[3H]Ile': [2444], '(Amersham': [2445, 2728, 3042, 4187], 'Biosciences).': [2446, 2872, 3043], 'Pulse-chase': [2447], 'experiments': [2448, 2714], '[35S]Met/Cys,': [2450], 'A23187': [2457], '(2': [2458], 'μm),': [2459], 'brefeldin': [2460], 'A': [2461, 3577, 3615, 3714, 4067], '(2.5': [2462], 'μg/ml),': [2463], 'thapsigargin': [2464], '(300': [2465], 'nm),': [2466, 2470], 'nocodazole': [2468], '(66': [2469], 'carried': [2472], 'out': [2473], 'previously': [2476, 3485, 4197, 4247], '26Benjannet': [2522], 'Elagoz': [2524, 2604, 3488], 'Cromlish': [2536, 2616, 3500], 'Sisodia': [2538, 2618, 3502], 'Checler': [2540, 2620, 3504], '276:': [2550, 2630, 3514], '10879-10887Abstract': [2551, 2631, 3515], '(279)': [2559, 2639, 3523], 'lysed': [2565], 'modified': [2567, 2804], 'RIPA': [2568, 2707], 'buffer': [2569, 2708, 2961], '(150': [2570], 'NaCl,': [2572, 3360], '50': [2573, 2814, 2923, 2927, 3394], 'Tris-HCl': [2575], '(pH': [2576, 3636, 3656, 3735, 3748, 3759], '7.5),': [2577], '1%': [2578], 'Nonidet': [2579], 'P-40,': [2580], '0.5%': [2581, 3659, 3738, 3786], 'sodium': [2582, 3070], 'deoxycholate,': [2583], 'inhibitor': [2587], 'mixture': [2588], '(Roche': [2589, 2965, 4157], 'Applied': [2590, 2966, 3528, 4158], 'Science),': [2591], 'after': [2592, 4110], 'lysates': [2595, 3669], 'media': [2597, 3212, 3236], 'prepared': [2599, 3110, 3671, 4466], 'immunoprecipitations': [2601], '(26Benjannet': [2602, 3486], 'antibodies': [2643, 3027], 'V5-mAb': [2648, 3700], '(1:500;': [2649], 'Invitrogen)': [2650], 'LDLR-C7-mAb': [2652, 2823], '(1:200;': [2653], 'Santa': [2654], 'Cruz': [2655, 2842], 'Biotechnology),': [2656], 'rabbit': [2659], 'antibody': [2660, 2837, 3036], 'directed': [2661], 'against': [2662, 3853], 'acids': [2664, 4346], '184–196': [2665], '(1:400;': [2669], 'Research': [2670], 'Diagnostics': [2671], 'Inc.).': [2672], 'Immunoprecipitates': [2673], 'resolved': [2675, 3460], 'SDS-PAGE': [2677, 3462, 3549, 4329], '8%': [2679], 'Tricine': [2680, 3464], 'gels': [2681], 'autoradiographed.': [2683, 3475], 'For': [2684, 2873, 3534, 3562], 'Western': [2685, 2892, 3008], 'blots,': [2686], 'overnight': [2700], 'before': [2701, 3080, 4108, 4118], 'extraction': [2703], 'above': [2706, 4310], 'lacking': [2709], 'SDS.': [2710], 'Most': [2711], 'these': [2713], 'repeated': [2716, 4412], 'least': [2718], 'three': [2719, 2887, 3347, 3652, 3744, 4486], 'times.': [2720], 'Quantitation': [2721, 3044], 'performed': [2723, 2853, 3046, 3798, 4062], 'Storm': [2726], 'Imager': [2727], 'Biosciences)': [2729, 4188], 'ImageQuant': [2733], 'version': [2734], '5.2': [2735], 'software.': [2736], 'Subjects': [2737], 'Analysis': [2740], 'Transformed': [2742], 'Lymphoblasts—Epstein-Barr': [2743], 'virus': [2744], '(EBV)-transformed': [2745], '(27Louie': [2747], 'L.G.': [2748], 'King': [2749], 'M.C.': [2750, 3116], 'Am.': [2751], '1991;': [2755], '48:': [2756], '637-638PubMed': [2757], 'normolipidemic': [2775, 3054], '(six': [2777], 'each)': [2779], 'subject': [2782], 'P664L': [2786], 'gene.': [2791], 'All': [2792], 'gave': [2794], 'informed': [2796], 'consent.': [2797], 'EBV-transformed': [2798], 'cultured': [2801], "Dulbecco's": [2803], 'medium': [2806], '(Invitrogen),': [2807], '10%': [2808, 2911, 2919], 'fetal': [2809, 2912], 'calf': [2810], '(Biomedia),': [2812], 'units/ml': [2815], 'penicillin/streptomycin': [2816], '(Sigma).': [2817], 'Lymphoblasts': [2818], 'stained': [2820, 2832], '30': [2825, 2845], 'min': [2826, 2846, 2956, 3321, 3405, 3640, 3664], 'ice.': [2828, 2848], 'Cells': [2829, 3249, 3387], 'goat': [2835], 'anti-mouse': [2836], 'conjugated': [2838], 'phycoerythrin': [2840], '(Santa': [2841], 'Biotechnology)': [2843], 'Flow': [2849], 'cytometry': [2850], 'analysis': [2851, 3566, 3796, 4140], 'FACScan': [2857], 'Cytometer': [2858], '(BD': [2859, 2871], 'Biosciences),': [2860], 'analyzed': [2865, 3006, 4184], 'CellQuest': [2868], 'software': [2869], 'package': [2870], 'sample,': [2875], '10,000': [2876], 'live': [2877], 'events': [2878], 'collected,': [2880], 'results': [2883, 4296], 'confirmed': [2885], 'independent': [2888], 'experiments.': [2889], 'Protein': [2890, 3532, 3810, 3830], 'Solubilization,': [2891], 'Blots,': [2893], 'Immunodetection—Cells': [2898], '60-mm': [2900], 'plates': [2901, 3177, 3316], '24': [2905], 'h': [2906, 3182, 3703, 3717, 4117], 'MEM': [2908, 3202], 'plus': [2909, 2922, 3204, 3225, 3237, 3393, 3420], 'no': [2916], 'addition': [2917], 'lipoprotein-deficient': [2920], 'μm': [2924, 2928, 3073, 3078], 'compactin': [2925], '28Goldstein': [2933], 'Basu': [2935], 'S.K.': [2936], 'Methods': [2939], 'Enzymol.': [2940], '1983;': [2941, 3372], '241-260Crossref': [2943], '(1287)': [2946], 'Scholar.': [2948], 'washed,': [2952], '10': [2955, 3072, 3077, 3187, 3756], '1.4%': [2958], 'Triton': [2959, 3660, 3739], 'X-100': [2960, 3661, 3740], 'Science)': [2967, 4159], 'ice,': [2969], 'homogenized,': [2971], 'lysate': [2974], 'clarified': [2976], '(29Yoshimura': [2977], 'Yoshida': [2979], 'Seguchi': [2981], 'Waki': [2983], 'Ono': [2985], 'Kuwano': [2987], '1987;': [2992], '262:': [2993], '13299-13308Abstract': [2994], 'Fifty': [3001], 'micrograms': [3002], 'blot': [3009], '(160': [3012], 'kDa)': [3013], 'subunit': [3017], '(85': [3018], 'kDa).': [3019], 'membranes': [3021], 'successively': [3023], 'primary': [3026], '(1:400,': [3028], 'LDLR;': [3029], '1:3000,': [3030], 'LRP1)': [3031], 'appropriate': [3034], 'secondary': [3035], 'ECL': [3040], 'Plus': [3041], 'above.': [3048], 'Isolation': [3050], '125I-Protein': [3052], 'Labeling—Human': [3053], 'plasma': [3055, 4045, 4133], '(Royal': [3056], 'Victoria': [3057], 'Hospital,': [3058], 'Montreal,': [3059], 'Quebec,': [3060], 'Canada)': [3061], 'supplemented': [3063], '0.3': [3065], 'EDTA,': [3067], 'azide,': [3071], 'phenylmethylsulfonyl': [3074], 'fluoride,': [3075], 'Trolox': [3079], 'isolation': [3082], 'lipoproteins,': [3084], 'achieved': [3087], 'ultracentrifugation': [3089], '(30Hatch': [3092], 'F.T.': [3093], 'Adv.': [3094], '1968;': [3097], '6:': [3098], '1-68Crossref': [3099], '(d': [3105], '=': [3106], '1.025–1.063': [3107], 'g/ml)': [3108], '(31Brissette': [3113], 'Charest': [3115], 'Falstrault': [3117], '1996;': [3121], '318:': [3122], '841-847Crossref': [3123], '(35)': [3126], 'holotransferrin': [3131, 3307], '125I-labeled': [3133], 'modification': [3136], '(32Langer': [3137], 'Strober': [3139], 'W.': [3140, 4199], 'Levy': [3141], 'R.I.': [3142], '1972;': [3146], '51:': [3147], '1528-1536Crossref': [3148], '(387)': [3151], 'iodine': [3156], 'monochloride': [3157], 'method.': [3158], 'radioactivity': [3161], '∼1.5': [3163], 'cpm/μg': [3166], 'holotransferrin.': [3170], '125I-LDL': [3171, 3190, 3252], 'Degradation': [3172, 3288], 'Assay—HepG2': [3173], '6-well': [3176], '4': [3181, 3705, 4116], '37': [3184, 3323, 3407], '°C': [3185, 3324, 3408, 3706, 4138], 'volume': [3194], '500': [3196, 3221, 3358], 'μl': [3197, 3200, 3222, 3332, 3572, 3774, 4178], 'containing': [3198, 3712], '(2×)': [3203], '4%': [3205], 'BSA': [3206, 3227], '(MEM-BSA),': [3207], 'pH': [3208, 3335, 3361, 3580], '7.4,': [3209], 'collected.': [3214], 'once': [3219], 'PBS': [3224, 3635, 3655, 3734, 3747], '0.2%': [3226], 'twice': [3229], 'ml': [3232, 3257], 'PBS.': [3234, 3386], 'Incubation': [3235], 'first': [3239, 4485], 'wash': [3240, 3383], 'pooled': [3242, 4179], 'precipitated': [3244], '12%': [3246], 'trichloroacetic': [3247, 3414], 'acid.': [3248], 'homogenized': [3254], '1.5': [3256], '0.2': [3259, 3430], 'n': [3260, 3431], 'NaOH,': [3261], 'content': [3265], 'assayed': [3267], '(33Lowry': [3268], 'O.H.': [3269], 'Rosebrough': [3270], 'N.J.': [3271], 'Farr': [3272], 'A.L.': [3273], 'Randall': [3274], 'R.J.': [3275], '1951;': [3279], '193:': [3280], '265-275Abstract': [3281], 'estimated': [3290, 3895], 'protein/mg': [3295], '125I-Holotransferrin': [3299], 'Recycling': [3300], 'Assay—To': [3301], 'estimate': [3302], 'efficiency': [3304], 'iron-loaded': [3306], '(Sigma)': [3308], 'recycling': [3309], 'cells,': [3312], '12-well': [3315], '15': [3320, 3639, 3663, 3742, 3751], '0.5': [3326, 3574, 3631], '125I-transferrin': [3329, 3340, 3411, 3422], 'MEM-BSA,': [3334], '7.4': [3336], '(pulse).': [3337], 'Cell': [3338, 3370, 3668], 'surface-bound': [3339], 'dissociated': [3342], 'rapid': [3348], 'washes': [3349], 'acetic': [3351, 3355], 'saline': [3352], '(0.2': [3353], '2.5)': [3362], 'ice': [3364], '(34Hopkins': [3365], 'C.R.': [3366], 'Trowbridge': [3367], '97:': [3373], '508-521Crossref': [3374], '(448)': [3377], 'followed': [3380], 'ice-cold': [3385], 're-fed': [3389], 'fresh': [3391], 'MEM-BSA': [3392], 'μg/ml': [3395, 3690], 'unlabeled': [3396], 'transferrin,': [3397], '60': [3404], '(chase).': [3409], 'Recycled': [3410], 'acid-precipitable': [3415], 'fraction,': [3416], 'cell-associated': [3418], '(bound': [3419], 'internalized)': [3421], 'measured': [3424, 4150], 'homogenizing': [3426], 'NaOH.': [3432], 'No': [3433], 'degradation': [3434, 4404], 'chase': [3439], 'phase.': [3440], 'Microsequencing': [3441], 'Mass': [3443, 3794], 'Spectrometry': [3444], 'Analyses—Transfected': [3445], 'pulse-labeled': [3449], '[3H]Ile.': [3453], 'Lysates': [3454], 'immunoprecipitated': [3456], 'V5-mAb,': [3459], '(8%': [3463], 'gel),': [3465, 3552], 'blotted': [3467], 'Immobilon': [3470], 'PSQ': [3471], 'membrane': [3472], '(Millipore)': [3473], 'identified': [3477, 4483], 'radioactive': [3478], 'microsequenced': [3482], 'Biosystems': [3529, 3595, 3833], 'Procise': [3530], 'cLC': [3531], 'Sequencer.': [3533], 'cold': [3535, 4481], 'sequencing,': [3536], 'transfectant': [3544], 'V5-immunoprecipitated,': [3546], 'separated': [3547], '(12%': [3550], 'glycine': [3551], 'electroblotted': [3553], 'onto': [3554], 'polyvinylidene': [3555], 'difluoride,': [3556], 'purified': [3559], 'band': [3560], 'microsequenced.': [3561], 'spectral': [3565, 3795], 'immunocaptured': [3568], 'mg/ml': [3575], '(in': [3578], '8.2)': [3581], 'covalently': [3583], 'bound': [3584], 'spots': [3587, 3711, 3725], 'pre-activated': [3590, 3621], 'PS10': [3591], 'ProteinChip': [3592], 'Array': [3593], '(Ciphergen': [3594, 3832], 'Inc.,': [3596, 3834], 'Palo': [3597, 3835], 'Alto,': [3598, 3836], 'CA)': [3599], 'incubation': [3601, 3626], 'humid': [3604], 'chamber': [3605], 'temperature': [3608], '(RT)': [3609], 'h.': [3612], 'solution': [3616], 'removed,': [3618, 3722], 'residual': [3620], 'sites': [3622], 'blocked': [3624], 'chip': [3629, 3649, 3765], 'm': [3632], 'ethanolamine': [3633], '8)': [3637], 'temperature.': [3643, 3667], 'Following': [3644], 'blocking': [3646], 'step,': [3647], '7.4)': [3657, 3736, 3749, 3760], 'pools': [3675, 3877], 'expressing': [3676, 3985], 'grown': [3682], 'tunicamycin': [3691], '18': [3693], 'h,': [3694], 'preincubated': [3697], '1:1000': [3699], 'added': [3708, 3790], '2': [3716], 'RT.': [3719], 'Samples': [3720], 'sequentially': [3727], 'RT': [3730], 'time': [3732, 4128], 'min,': [3743, 3752], 'finally': [3754], 'Hepes': [3758], 'min.': [3763], 'allowed': [3767], 'dry': [3769], 'saturated': [3776], 'sinapinic': [3777], '(3,5-dimethoxy-4-hydroxycinnamic': [3779], 'acid;': [3780], 'Sigma)': [3781], '50%': [3783], 'acetonitrile': [3784], 'trifluoroacetic': [3787], 'spot.': [3793], 'spectrometry': [3805], '(SELDI-TOF-MS)': [3806], 'Ciphergen': [3809], 'Biology': [3811], 'System': [3812], 'II': [3813, 4156], '(PBS': [3814], 'II).': [3815], 'Analyses': [3816], 'represent': [3817, 4285], 'average': [3819], '100': [3821], 'shots,': [3822], 'masses': [3824], 'calibrated': [3826], 'externally': [3827], 'All-in-1': [3829], 'Standards': [3831], 'CA).': [3837], 'Ribonucleic': [3838], 'Acid': [3839], 'Interference': [3840], 'Knockdown': [3841], 'Cells—Three': [3847], '19-mer': [3848], 'double-stranded': [3849], 'oligonucleotides': [3850], 'designed': [3852], 'segments': [3855], 'sequences:': [3863], '5′-AATGGTTCCGACTTGTCCTC-3′,': [3864], '5′-AGCAAGTGTGACAGTCATGGC-3′,': [3865], '5′-AGGCATTCAATCCTCAGGTCT-3′.': [3867], 'pRNA-U6.1': [3872, 3988], 'vector': [3873], '(GenScript),': [3874], 'hygromycin-resistant': [3876], 'isolate': [3885], 'individual': [3886], 'clones.': [3887], 'Their': [3888], 'Northern': [3897], 'blotting': [3898], 'probe,': [3903], 'spanning': [3904], 'nucleotides': [3905], '484–1059,': [3906], 'selected': [3943], 'clones,': [3944], 'A,': [3945], 'B,': [3946], 'C,': [3948], 'analyze': [3952], 'uptake': [3962, 3981], 'FACS.': [3964], 'clones': [3972], 'A–C': [3973], 'calculated': [3975], 'respect': [3977], 'control': [3983], 'vector.': [3989], 'Vivo': [3991], 'Expression': [3992], 'Mice—Wild': [3996], 'female': [3998], 'C57BL/6': [4001], 'Jackson': [4007], 'Laboratories': [4008], '(Bar': [4009], 'Harbor,': [4010], 'ME).': [4011], 'Mice': [4012, 4076, 4113], 'maintained': [4014], '12-h': [4017], 'light/dark': [4018], 'cycle': [4019], 'fed': [4021], 'chow': [4023], 'diet.': [4024], 'Before': [4025], 'determined,': [4032], 'divided': [4037], 'mean': [4044], 'different.': [4053], 'Each': [4054], 'contained': [4056], 'four': [4057], 'Statistical': [4059], "Student's": [4064], 't': [4065, 4526], 'test.': [4066], 'value': [4068], 'p': [4070], '<': [4071], '0.05': [4072], 'considered': [4074], 'significant.': [4075], 'injected': [4078], 'intravenously': [4079], 'tail': [4082], 'vein': [4083], '1011': [4087], 'particles': [4088], 'recombinant': [4090], 'adenovirus': [4091, 4111], 'day': [4093], '0': [4094], 'study.': [4097], 'Blood': [4098], 'retro-orbital': [4103], 'plexus': [4104], 'injection.': [4112], 'fasted': [4115], 'bleeding,': [4119], 'blood': [4121], 'always': [4123], 'drawn': [4124], 'day.': [4130], 'Aliquots': [4131], 'stored': [4135], '–20': [4137], 'until': [4139], 'lipids.': [4142], 'Plasma': [4143, 4175], 'HDL-C,': [4145], 'triglyceride': [4147], 'enzymatically': [4151], 'Cobas': [4154], 'Fara': [4155], 'Sigma': [4161], 'reagents.': [4162], 'Non-HDL': [4163], 'determined': [4167, 4227], 'subtracting': [4169], 'HDL-C': [4170], 'cholesterol.': [4174], 'samples': [4176], '(200': [4177], 'group)': [4182], 'FPLC': [4186, 4224], 'Superose': [4190], '6': [4191, 4307], 'columns': [4192], 'series': [4194], '(35Jin': [4198], 'Millar': [4200], 'Broedl': [4202], 'Glick': [4204], 'Rader': [4206], '357-362Crossref': [4213], '(202)': [4216], 'concentrations': [4221], 'fractions': [4225], 'assay': [4231], '(Wako': [4232], 'Pure': [4233], 'Chemical': [4234], 'Industries': [4235], 'Ltd.,': [4236], 'Osaka,': [4237], 'Japan).': [4238], 'Mutations': [4239], 'Affecting': [4240], 'Zymogen': [4242], 'Processing': [4243], 'NARC-1—We': [4245], 'underlined': [4250, 4262], 'prodomain': [4254], 'sequence': [4255, 4311], 'proNARC-1,': [4257], 'i.e.': [4258], 'YVVVLKEETHL': [4259], '(where': [4260, 4514], 'boldface': [4263], 'L': [4264], 'indicates': [4265, 4516], 'P1': [4267, 4518], 'position),': [4269], 'play': [4270], 'critical': [4272], 'concluded': [4281], 'Leu82↓': [4283], 'may': [4284], 'zymogen-processing': [4287, 4360, 4509], 'site.': [4288], 'based': [4292], 'microsequencing': [4295, 4492], '[3H]Leu': [4299], 'Leu': [4304], 'position': [4306, 4501], '(see': [4308], 'KEETHL).': [4312], 'However,': [4313], 'deduction': [4315], 'consistent': [4318], 'observed': [4321], 'apparent': [4322], 'molecular': [4323], '∼14': [4326], 'kDa': [4327, 4340], 'co-immunoprecipitating': [4332], 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