Publication Information

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'https://openalex.org/W4212997115', 'https://openalex.org/W624844300'], 'related_works': ['https://openalex.org/W2552955488', 'https://openalex.org/W2301207443', 'https://openalex.org/W2145412238', 'https://openalex.org/W2114652916', 'https://openalex.org/W2078985265', 'https://openalex.org/W2027591857', 'https://openalex.org/W1996070288', 'https://openalex.org/W1514008659', 'https://openalex.org/W133928371', 'https://openalex.org/W106432333'], 'abstract_inverted_index': {'Atovaquone': [0, 56, 254, 310, 1220, 2309, 2710, 2829, 3352, 3590, 4046, 4282], 'is': [1, 6, 22, 162, 255, 260, 276, 416, 515, 565, 637, 1080, 1984, 2185, 2731, 2863, 2878, 2885, 2904, 2953, 2976, 2986, 3008, 3028, 3223, 3228, 3575, 3737, 3753, 3763, 3867, 3986, 4077, 4169, 4209, 4221, 4228, 4249, 4260, 4283, 4310, 4346], 'a': [2, 52, 136, 182, 256, 306, 390, 436, 566, 1005, 1130, 1222, 1492, 1548, 1564, 1571, 1578, 1599, 1657, 1711, 1842, 1907, 1972, 2108, 2131, 2147, 2175, 2222, 2241, 2280, 2357, 2397, 2423, 2449, 2470, 2571, 2621, 2732, 2886, 2906, 2978, 3136, 3180, 3229, 3236, 3553, 3666, 3679, 3795, 4214, 4293, 4298, 4303, 4364, 4451, 4475], 'substituted': [3, 257], '2-hydroxynaphthoquinone': [4, 258], 'that': [5, 100, 135, 212, 259, 354, 389, 466, 586, 641, 764, 1132, 1680, 1979, 2647, 2758, 2875, 2970, 3011, 3225, 3870, 3910, 3976, 4296, 4433], 'used': [7, 261, 1525, 1880, 2220, 2369, 2421], 'therapeutically': [8, 262], 'to': [9, 24, 81, 103, 128, 152, 179, 198, 217, 225, 238, 263, 278, 335, 357, 382, 406, 433, 452, 471, 479, 492, 539, 803, 967, 978, 983, 1010, 1396, 1595, 1808, 1835, 1961, 2042, 2066, 2107, 2130, 2199, 2324, 2355, 2389, 2432, 2469, 2591, 2778, 2788, 2798, 2839, 2865, 2867, 2898, 2910, 2966, 3124, 3538, 3580, 3662, 3669, 3783, 3869, 3909, 3953, 3957, 4004, 4010, 4103, 4140, 4154, 4177, 4285, 4292, 4300, 4319, 4367, 4447], 'treat': [10, 264], 'Plasmodium': [11, 265, 649, 1042], 'falciparum': [12, 266], 'malaria,': [13, 267], 'Pneumocystis': [14, 268, 724], 'carinii': [15, 269, 725, 1045], 'pneumonia,': [16, 270], 'and': [17, 84, 243, 271, 338, 497, 542, 581, 595, 704, 721, 755, 761, 1039, 1043, 1057, 1076, 1165, 1174, 1208, 1233, 1243, 1275, 1293, 1339, 1381, 1403, 1427, 1436, 1467, 1477, 1485, 1502, 1563, 1616, 1644, 1685, 1689, 1799, 1803, 1887, 1915, 1939, 1951, 2089, 2146, 2168, 2202, 2310, 2337, 2343, 2396, 2512, 2517, 2548, 2699, 2711, 2793, 2880, 2959, 2973, 3038, 3055, 3062, 3087, 3115, 3149, 3187, 3193, 3337, 3358, 3502, 3524, 3535, 3544, 3657, 3759, 3791, 3906, 4076, 4111, 4120, 4144, 4213, 4235, 4240, 4256, 4270, 4291, 4314, 4328, 4340, 4420], 'Toxoplasma': [18, 272, 664], 'gondii': [19, 273], 'toxoplasmosis.': [20, 274], 'It': [21, 275], 'thought': [23, 277], 'act': [25, 279], 'on': [26, 280, 752, 1124, 1652, 2240, 2565, 2652, 2676, 2988, 3021, 3596, 3724, 3814, 4015, 4253, 4398, 4425], 'these': [27, 222, 281, 476, 957, 1027, 1125, 3860], 'organisms': [28, 282], 'by': [29, 283, 790, 1170, 1245, 1258, 1341, 1408, 1441, 1703, 1858, 2074, 2113, 2494, 2620, 2837, 3145, 3272, 3838, 4181], 'inhibiting': [30, 284], 'the': [31, 39, 44, 58, 71, 75, 86, 90, 94, 104, 109, 117, 129, 145, 155, 159, 165, 169, 188, 192, 195, 213, 218, 230, 239, 245, 249, 285, 293, 298, 312, 325, 329, 340, 344, 348, 358, 363, 371, 383, 399, 409, 413, 419, 423, 442, 446, 449, 467, 472, 484, 493, 499, 503, 523, 596, 722, 750, 756, 765, 770, 791, 796, 804, 951, 960, 965, 968, 991, 996, 1012, 1018, 1031, 1069, 1106, 1112, 1117, 1134, 1141, 1146, 1154, 1157, 1163, 1234, 1253, 1400, 1404, 1419, 1433, 1437, 1487, 1498, 1503, 1645, 1667, 1673, 1681, 1696, 1812, 1822, 1830, 1850, 1853, 1863, 1867, 1875, 1898, 1923, 1926, 1929, 1952, 1963, 1967, 1982, 1990, 2025, 2029, 2034, 2043, 2049, 2055, 2064, 2117, 2121, 2137, 2141, 2153, 2159, 2164, 2169, 2178, 2227, 2230, 2248, 2253, 2267, 2338, 2344, 2351, 2371, 2374, 2434, 2457, 2463, 2484, 2489, 2502, 2536, 2541, 2555, 2561, 2566, 2579, 2582, 2593, 2605, 2612, 2625, 2644, 2648, 2656, 2661, 2666, 2677, 2687, 2695, 2700, 2705, 2761, 2769, 2779, 2801, 2832, 2868, 2890, 2899, 2912, 2923, 2929, 2935, 2957, 2967, 2974, 2982, 2989, 2992, 2999, 3012, 3017, 3022, 3033, 3039, 3043, 3048, 3067, 3073, 3080, 3088, 3098, 3108, 3110, 3140, 3150, 3163, 3176, 3199, 3209, 3226, 3233, 3243, 3247, 3262, 3275, 3291, 3299, 3328, 3354, 3364, 3369, 3376, 3488, 3493, 3533, 3549, 3562, 3569, 3572, 3583, 3588, 3593, 3597, 3604, 3612, 3616, 3625, 3634, 3658, 3670, 3674, 3725, 3729, 3739, 3744, 3750, 3755, 3760, 3765, 3775, 3780, 3785, 3788, 3810, 3815, 3819, 3827, 3831, 3842, 3851, 3855, 3874, 3912, 3938, 3942, 3946, 3960, 3983, 3998, 4011, 4016, 4020, 4048, 4060, 4068, 4071, 4085, 4089, 4097, 4108, 4112, 4117, 4123, 4128, 4131, 4138, 4141, 4145, 4152, 4155, 4194, 4202, 4217, 4230, 4254, 4257, 4263, 4266, 4273, 4288, 4312, 4315, 4320, 4356, 4360, 4368, 4373, 4377, 4381, 4392, 4399, 4416, 4426, 4434, 4448, 4453], 'cytochrome': [32, 142, 190, 286, 396, 444, 509, 540, 590, 592, 797, 1037, 1119, 1255, 1384, 1390, 1446, 2232, 2270, 2311, 2335, 2598, 2791, 3157, 3181, 3268, 3278, 3315, 4247, 4277, 4389], 'bc': [33, 45, 59, 110, 131, 147, 171, 240, 287, 299, 313, 364, 385, 401, 425, 494, 510, 531, 766, 969, 1120, 1147, 1167, 1228, 1286, 1391, 1590, 1660, 1748, 1869, 2233, 2271, 2770, 2781, 2833, 2901, 2937, 3023, 3141, 3158, 3269, 3285, 3377, 3495, 3618, 3675, 3745, 3833, 4022, 4050, 4073, 4204], '1': [34, 46, 60, 111, 132, 148, 172, 241, 288, 300, 314, 365, 386, 402, 426, 495, 511, 532, 767, 970, 1121, 1148, 1168, 1229, 1287, 1372, 1392, 1561, 1591, 1609, 1661, 1749, 1870, 2081, 2234, 2272, 2771, 2782, 2834, 2902, 2938, 3024, 3142, 3159, 3270, 3286, 3378, 3496, 3619, 3676, 3746, 3834, 4023, 4051, 4074, 4205], 'complex.': [35, 289, 1122, 1149, 1871, 2772, 3025, 4206], 'We': [36, 290, 1678, 3477], 'have': [37, 291, 999, 1110, 1128, 2921, 4176], 'examined': [38, 292, 3479], 'interaction': [40, 294, 992, 1113, 3482, 4106], 'of': [41, 74, 93, 108, 141, 168, 194, 221, 234, 248, 295, 328, 347, 362, 395, 422, 448, 475, 488, 502, 527, 749, 759, 793, 950, 953, 962, 964, 990, 993, 1014, 1030, 1041, 1114, 1145, 1160, 1162, 1226, 1413, 1421, 1424, 1445, 1550, 1555, 1560, 1567, 1634, 1659, 1675, 1714, 1747, 1758, 1821, 1845, 1849, 1862, 1866, 1874, 1897, 1910, 1919, 1928, 1989, 2031, 2033, 2048, 2054, 2158, 2177, 2215, 2282, 2317, 2331, 2400, 2451, 2460, 2474, 2501, 2524, 2558, 2574, 2581, 2596, 2643, 2663, 2684, 2686, 2768, 2790, 2800, 2889, 2915, 2926, 2931, 2951, 3001, 3036, 3041, 3060, 3066, 3083, 3090, 3139, 3152, 3179, 3190, 3198, 3212, 3232, 3238, 3249, 3266, 3282, 3293, 3296, 3301, 3314, 3330, 3351, 3487, 3530, 3561, 3565, 3587, 3606, 3722, 3728, 3738, 3757, 3767, 3787, 3797, 3812, 3818, 3826, 3830, 3853, 3940, 3945, 3990, 3996, 4013, 4019, 4045, 4055, 4070, 4088, 4190, 4201, 4216, 4246, 4265, 4276, 4287, 4359, 4370, 4372, 4380, 4388, 4404, 4418, 4437, 4452], 'atovaquone': [42, 101, 126, 199, 236, 296, 355, 380, 453, 490, 760, 954, 994, 1015, 1115, 1138, 1635, 1888, 2216, 2319, 2653, 2664, 2884, 2916, 2927, 2952, 2984, 3037, 3061, 3084, 3146, 3220, 3331, 3505, 3531, 3632, 3723, 3813, 3977, 4056, 4090, 4191, 4384], 'with': [43, 63, 116, 206, 297, 317, 370, 460, 569, 801, 995, 1116, 1185, 1577, 1626, 1710, 1811, 1852, 1906, 2373, 2392, 2422, 2578, 2928, 2940, 3122, 3185, 3333, 3338, 3353, 3363, 3483, 3501, 3992, 4122, 4233, 4386, 4391], 'complex': [47, 61, 133, 173, 242, 301, 315, 387, 427, 496, 512, 520, 533, 768, 971, 1393, 1592, 1662, 1750, 2273, 2783, 2835, 2903, 2939, 3160, 3271, 3287, 3379, 3497, 3677, 3747, 3835, 4024, 4075], 'isolated': [48, 302, 997, 1290], 'from': [49, 79, 303, 333, 537, 1177, 1189, 1195, 1203, 1212, 1217, 1224, 1291, 1497, 1586, 1672, 1833, 1948, 2350, 2387, 2438, 2624, 2934, 3047, 3162, 3167, 3498, 3678, 3859, 3951, 4002, 4116], 'Saccharomyces': [50, 304, 1002], 'cerevisiae,': [51, 305], 'surrogate,': [53, 307], 'nonpathogenic': [54, 308], 'fungus.': [55, 309], 'inhibits': [57, 311, 2831], 'competitively': [62, 316], 'apparent': [64, 318, 3255], 'K': [65, 319, 1488, 3244, 3256, 3303], 'i': [66, 175, 202, 320, 429, 456, 1489, 3257], '=': [67, 176, 203, 321, 430, 457, 2080, 3205, 3258, 3305, 3519, 3522, 3526, 3542, 3546, 3557], '9': [68, 322, 3259], 'nm,': [69, 323], 'raises': [70, 324], 'midpoint': [72, 326, 3816, 3856, 3943, 3999, 4017], 'potential': [73, 327, 1831, 1855, 1902, 2070, 3817, 3845, 3857, 3944, 4000, 4018], 'Rieske': [76, 95, 118, 330, 349, 372, 597, 2035, 2050, 2802, 3355, 3365, 3489, 3513, 3598, 3671, 3731, 3740, 3820, 3876, 3915, 3947, 3984, 4218, 4289, 4374], 'iron-sulfur': [77, 119, 331, 373, 598, 1969, 2339, 2803, 3366, 3490, 3732, 3741, 3821, 3828, 3948, 4219, 4226], 'protein': [78, 332, 1851, 1878, 1970, 1992, 2036, 2340, 2804, 3367, 3672, 3877, 3916, 4220, 4290, 4406], '285': [80, 334, 3863, 3952, 4003], '385': [82, 336, 3954], 'mV,': [83, 337, 1837, 4008], 'shifts': [85, 339, 3786], 'g': [87, 341, 3563, 3627], 'values': [88, 342, 1490, 1501, 1954, 3628], 'in': [89, 144, 158, 209, 343, 398, 412, 463, 522, 795, 956, 976, 1008, 1017, 1064, 1239, 1282, 1359, 1399, 1418, 1450, 1460, 1598, 1683, 1691, 1695, 1706, 1816, 1824, 1891, 2063, 2087, 2120, 2136, 2333, 2353, 2483, 2504, 2533, 2760, 2955, 2977, 2998, 3053, 3056, 3076, 3097, 3117, 3172, 3202, 3246, 3290, 3327, 3375, 3492, 3508, 3568, 3611, 3623, 3633, 3673, 3743, 3754, 3764, 3779, 3959, 4047, 4059, 4079, 4101, 4127, 4165, 4185, 4193, 4211, 4223, 4272, 4325, 4415], 'EPR': [91, 345, 1522, 3485, 3599, 3726], 'spectrum': [92, 346, 1899, 3600, 3727, 3736, 3752, 3762, 3782], 'center.': [96, 350], 'These': [97, 227, 351, 481, 4158], 'results': [98, 228, 352, 482, 2539, 3166, 3201], 'indicate': [99, 353], 'binds': [102, 237, 356, 491, 2759, 2777, 3978, 4362], 'ubiquinol': [105, 359, 538, 762, 1142, 2762, 2869, 3372, 4061, 4195], 'oxidation': [106, 360, 1143, 2763, 2870, 3373, 4062, 4196], 'pocket': [107, 361, 1144, 2764, 3374, 4063, 4197], 'complex,': [112, 149, 366, 403, 3620], 'where': [113, 367], 'it': [114, 368, 3095, 3222], 'interacts': [115, 369, 4385], 'protein.': [120, 374, 2051, 4375], 'A': [121, 375, 1200, 1756, 2196, 2327, 2361, 2629, 3559, 4402], 'computed': [122, 376], 'energy-minimized': [123, 377, 2091, 2213, 2924, 2949, 3081, 4053], 'structure': [124, 378, 1079, 2104, 2265, 2437, 2466, 2564, 2569, 2925, 2930, 2950, 2985, 3054, 3089, 3101, 4054, 4189], 'for': [125, 164, 379, 418, 578, 1026, 1137, 1156, 1491, 1649, 1881, 2152, 2225, 2365, 2442, 2660, 2704, 2895, 3242, 3261, 3571, 3631, 3665, 3873, 3911, 4180], 'liganded': [127, 381], 'yeast': [130, 160, 189, 196, 384, 414, 443, 450, 1023, 1070, 1118, 1164, 1232, 1240, 1292, 2231, 2269, 2780, 2900, 2936, 3099, 3267, 3284, 3635, 3730, 3832, 3875, 4072, 4203], 'suggests': [134, 388], 'phenylalanine': [137, 391], 'at': [138, 154, 392, 408, 1140, 1386, 1455, 1547, 1752, 1841, 1900, 1932, 2058, 2279, 2378, 2765, 3072, 3218, 3368, 3517, 3962, 4064, 4198, 4229, 4395, 4409, 4430], 'position': [139, 157, 393, 411, 4396], '275': [140, 394], 'b': [143, 397, 798, 1038, 1256, 2312, 2336, 2599, 2792, 4208, 4248, 4278, 4390], 'bovine': [146, 170, 400, 424, 1166, 1294, 3617, 3913, 4021], 'as': [150, 404, 1004, 1261, 1297, 2221, 2481, 2659, 2703, 3094, 3567, 3601, 3629, 3794, 3841, 3969, 3971], 'opposed': [151, 405], 'leucine': [153, 407], 'equivalent': [156, 410], 'enzyme,': [161, 415, 1483], 'responsible': [163, 417], 'decreased': [166, 200, 420, 454], 'sensitivity': [167, 193, 220, 421, 447, 474], '(K': [174, 201, 428, 455], '80': [177, 431], 'nm)': [178, 205, 432, 459, 1941], 'atovaquone.': [180, 226, 434, 480, 3273, 3297, 3484], 'When': [181, 435, 2981], 'L275F': [183, 214, 437, 468, 1235, 1248, 2601, 2649, 2678, 2689], 'mutation': [184, 438, 1249, 2600, 2650], 'was': [185, 439, 769, 1024, 1188, 1193, 1201, 1215, 1221, 1250, 1357, 1394, 1406, 1439, 1448, 1593, 1670, 1751, 1806, 1856, 1959, 2037, 2085, 2093, 2105, 2127, 2219, 2237, 2266, 2341, 2368, 2420, 2430, 2454, 2467, 2550, 2602, 2618, 2635, 2692, 3147, 3154, 3288, 3836, 3846, 3862, 4057, 4091], 'introduced': [186, 440, 1251], 'into': [187, 441, 1252, 1432, 2229, 2604, 2665], 'b,': [191, 445, 591], 'enzyme': [197, 451, 519, 564, 1071, 3186, 3636], '100': [204, 458, 1715], 'no': [207, 461, 988], 'loss': [208, 462], 'activity,': [210, 464], 'confirming': [211, 465], 'exchange': [215, 469], 'contributes': [216, 470], 'differential': [219, 246, 473, 500, 1158], 'two': [223, 477, 2993, 3013, 3068, 3111, 3118], 'species': [224, 478], 'provide': [229, 483], 'first': [231, 485], 'molecular': [232, 486, 1135, 2114, 2143, 2160, 2461], 'description': [233, 487, 2176], 'how': [235, 489], 'explain': [244, 498], 'inhibition': [247, 501, 1161, 3153], 'fungal': [250, 504], 'versus': [251, 505, 1457, 3215, 3322], 'mammalian': [252, 506], 'enzymes.': [253, 507], 'The': [508, 530, 563, 575, 747, 1247, 1389, 1589, 1622, 1745, 1826, 1884, 2052, 2069, 2102, 2123, 2155, 2212, 2263, 2403, 2499, 2615, 2681, 2892, 2948, 3064, 3165, 3308, 3511, 3528, 3734, 3769, 3823, 4225, 4243, 4307, 4322], '(EC': [513], '1.10.2.2)': [514], 'an': [516, 638, 1411, 1451, 1470, 1707, 1916, 1987, 2078, 2090, 3203, 3254, 3360, 3994, 4182], 'essential': [517, 576], 'respiratory': [518], 'present': [521, 1840], 'inner': [524], 'mitochondrial': [525, 1254], 'membrane': [526], 'eukaryotic': [528], 'organisms.': [529], 'catalyzes': [534], 'electron': [535, 579, 1528, 2082], 'transfer': [536, 580], 'c': [541, 593, 1350, 1354, 1385, 1447, 3182, 3279, 3316], 'concomitantly': [543], 'translocates': [544], 'protons': [545], 'across': [546, 4262], 'membranes': [547], '(1Trumpower': [548], 'B.L.': [549, 1303, 1327, 1728, 2007, 2850, 3410, 3644, 3889, 3924, 4032], 'Gennis': [550], 'R.B.': [551], 'Annu.': [552], 'Rev.': [553], 'Biochem.': [554, 654, 776, 864, 883, 1510], '1994;': [555, 4466], '63:': [556], '675-716Crossref': [557], 'PubMed': [558, 659, 677, 699, 716, 742, 781, 832, 852, 869, 888, 911, 944, 1101, 1315, 1334, 1515, 1740, 2019, 2304, 2726, 2753, 2824, 2860, 3398, 3420, 3437, 3459, 3472, 3654, 3696, 3718, 3901, 3934, 4042, 4469], 'Scopus': [559, 660, 678, 700, 717, 743, 782, 833, 853, 870, 889, 912, 945, 1102, 1316, 1335, 1516, 1741, 2020, 2305, 2416, 2727, 2754, 2825, 3399, 3438, 3473, 3697, 3902, 4470], '(468)': [560], 'Google': [561, 608, 635, 662, 680, 702, 719, 745, 784, 835, 855, 872, 891, 914, 947, 1104, 1318, 1337, 1518, 1743, 2022, 2307, 2418, 2729, 2756, 2827, 2861, 3401, 3421, 3440, 3460, 3475, 3655, 3699, 3719, 3904, 3935, 4043, 4472], 'Scholar).': [562, 746, 785, 948, 1066, 1284, 1519, 1744, 2023, 2211, 2308, 2828, 3476, 3936, 4473], 'functional': [567], 'dimer,': [568], 'variable': [570], 'subunit': [571], 'composition': [572], 'among': [573], 'species.': [574], 'subunits': [577], 'energy': [582, 2110, 2125, 2134, 2436, 2465, 2544, 2645, 2683, 4125], 'transduction': [583], 'are': [584, 1687, 1693, 1818, 2061, 2962, 3070, 3078, 3113, 3170, 3506, 3660, 3772, 4279, 4330, 4334, 4338, 4343, 4441], 'those': [585, 1040, 1690, 3663], 'contain': [587], 'prosthetic': [588], 'groups,': [589], '1,': [594, 2919], 'protein.Atovaquone': [599], '(2-[trans-4-(4′-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-hydroxynaphthoquinone)': [600], '(2Wendel': [601], 'W.B.': [602], 'Fed.': [603], 'Proc.': [604], '1946;': [605], '5:': [606], '406-407PubMed': [607], 'Scholar,': [609, 836, 856, 873, 892, 915, 1319, 3402, 3422, 3441, 3461, 3700], '3Hudson': [610], 'T.': [611, 619, 1089, 1720, 1999, 2292, 2716, 2812, 2848, 3408, 3447, 3466, 3642, 3706, 3881, 3922, 4030], 'Dickins': [612], 'M.': [613, 623, 651, 653, 735, 773, 775, 811, 819, 894], 'Ginger': [614], 'C.D.': [615], 'Gutteridge': [616, 730], 'W.E.': [617, 731], 'Holdich': [618], 'Hutchinson': [620], 'D.B.A.': [621], 'Pudney': [622, 652, 734, 774], 'Randall': [624], 'A.W.': [625], 'Latter': [626, 732], 'V.S.': [627, 733], 'Drugs': [628], 'Exp.': [629], 'Clin.': [630], 'Res.': [631], '1991;': [632, 674], '17:': [633], '427-435PubMed': [634], 'Scholar)': [636, 720, 1338, 2419, 2532, 2730, 2757, 3905], 'anti-protozoal': [639], 'compound': [640, 3227], 'has': [642, 787, 986, 1971, 2651], 'broad-spectrum': [643], 'activity': [644, 1356, 3281, 3318], 'against': [645], 'apicomplexan': [646], 'parasites': [647], 'including': [648, 1761, 2174, 2633], '(4Fry': [650, 772], 'Pharmacol.': [655, 777, 1511], '1992;': [656, 778], '43:': [657, 779], '1545-1553Crossref': [658, 780], '(401)': [661, 783], 'Scholar),': [663, 681, 703, 2511, 2862, 3656], '(5Araujo': [665], 'F.G.': [666], 'Huskinson': [667], 'J.': [668, 693, 710, 821, 826, 927, 931, 935, 938, 1085, 1304, 1729, 2008, 2191, 2288, 2410, 2721, 2742, 2808, 2851, 3387, 3411, 3450, 3645, 3709, 3890, 3925, 4033, 4463], 'Remington': [669], 'J.S.': [670], 'Antimicrob.': [671, 736, 905], 'Agents': [672, 737, 906, 1062, 1280], 'Chemother.': [673, 738, 907], '35:': [675], '293-299Crossref': [676], '(173)': [679], 'Theileria': [682], '(6Boehm': [683], 'P.': [684, 817, 823, 917, 1044, 4479], 'Cooper': [685], 'K.': [686, 902, 3443, 3702], 'Hudson': [687], 'A.T.': [688], 'Elphick': [689], 'J.P.': [690, 2738, 3383], 'McHardy': [691], 'N.': [692, 896], 'Med.': [694], 'Chem.': [695, 1306, 1731, 2010, 2411, 2744, 2853, 3389, 3413, 3452, 3647, 3711, 3892, 3927, 4035], '1981;': [696], '24:': [697], '295-299Crossref': [698], '(38)': [701], 'Babesia': [705], '(7Hughes': [706], 'W.T.': [707, 727], 'Oz': [708], 'H.S.': [709], 'Infect.': [711, 827, 939], 'Dis.': [712, 828, 940], '1995;': [713], '172:': [714], '1042-1046Crossref': [715], '(57)': [718], 'fungus': [723], '(8Hughes': [726], 'Gray': [728], 'V.L.': [729], '1990;': [739], '34:': [740], '225-228Crossref': [741], '(106)': [744], 'effects': [748, 3595, 3605], 'drug': [751, 805, 966], 'cell': [753, 1709], 'respiration': [754], 'structural': [757, 2893, 2913, 2996, 3030], 'similarities': [758, 2997], 'suggested': [763], 'target': [771], 'This': [786, 1022, 1150, 1957, 2638, 3007, 3578, 3865, 3974], 'been': [788, 987, 1000], 'supported': [789], 'emergence': [792], 'mutations': [794], 'gene': [799, 1257], 'coincident': [800], 'resistance': [802, 955], '(9Walker': [806], 'D.': [807, 858, 1325], 'Wakefield': [808], 'A.': [809, 900], 'Dohn': [810], 'Miller': [812], 'R.': [813, 815, 2521, 2741, 3386], 'Baughman': [814], 'Hossler': [816, 920], 'Bartlett': [818], 'Smith': [820], 'Kazanjian': [822], 'Meshnick': [824, 936], 'S.R.': [825, 937], '1998;': [829, 1732, 2011, 3893], '178:': [830], '1767-1775Crossref': [831], '(117)': [834], '10Srivastava': [837], 'I.K.': [838], 'Morrisey': [839], 'J.M.': [840, 4462], 'Darrouzet': [841], 'E.': [842, 1718, 1997, 3879], 'Daldal': [843], 'F.': [844], 'Vaidya': [845], 'A.B.': [846], 'Mol.': [847, 863, 882, 4464], 'Microbiol.': [848], '1999;': [849, 866, 1307], '33:': [850], '704-711Crossref': [851], '(247)': [854], '11Syafruddin': [857], 'Siregar': [859], 'J.E.': [860], 'Marzuki': [861], 'S.': [862, 877, 2409, 3499], 'Parasitol.': [865, 884], '104:': [867], '185-194Crossref': [868], '(82)': [871], '12McFadden': [874], 'D.C.': [875], 'Tomavo': [876], 'Berry': [878], 'E.A.': [879], 'Boothroyd': [880], 'J.C.': [881], '2000;': [885, 908, 1093, 2296, 2816], '108:': [886], '1-12Crossref': [887], '(119)': [890], '13Korsinczky': [893], 'Chen': [895], 'Kotecka': [897], 'B.': [898, 1055, 1059, 1273, 1277, 2714], 'Saul': [899], 'Rieckmann': [901], 'Cheng': [903], 'Q.': [904], '44:': [909], '2100-2108Crossref': [910], '(289)': [913], '14Kazanjian': [916], 'Armstrong': [918], 'W.': [919, 933], 'P.A.': [921], 'Huang': [922], 'L.': [923, 929, 2195], 'Beard': [924], 'C.B.': [925], 'Carter': [926], 'Crane': [928], 'Duchin': [930], 'Burman': [932], 'Richardson': [934], '2001;': [941], '183:': [942], '819-822Crossref': [943], '(70)': [946, 2728], 'Because': [949], 'appearance': [952], 'protozoan': [958], 'parasites,': [959], 'mechanism': [961, 1013], 'binding': [963, 1139, 2897, 3019, 4186, 4192, 4267], 'must': [972], 'be': [973, 1074, 2325, 3968, 4178], 'fully': [974], 'understood': [975], 'order': [977, 2354, 4102], 'improve': [979], 'its': [980, 1036, 1077, 2785, 2795], 'effectiveness.': [981], 'However,': [982], 'date': [984], 'there': [985, 3027], 'characterization': [989, 3169], 'enzyme.We': [998], 'developing': [1001], 'cerevisiae': [1003, 3500], 'surrogate': [1006], 'organism': [1007], 'which': [1009, 1828, 2956, 4168], 'model': [1011, 1131, 1151], 'action': [1016], 'above': [1019], 'named': [1020], 'pathogens.': [1021], 'chosen': [1025, 1960], 'studies': [1028], 'because': [1029], 'high': [1032], 'sequence': [1033], 'identity': [1034], 'between': [1035, 1482, 2709, 3032, 4107], '(15Hill,': [1046, 1264], 'P.,': [1047, 1265], 'Kessl,': [1048, 1266], 'J.,': [1049, 1267], 'Fisher,': [1050, 1268], 'N.,': [1051, 1269], 'Meshnick,': [1052, 1270], 'S.,': [1053, 1271], 'Trumpower,': [1054, 1272], 'L.,': [1056, 1274], 'Meunier,': [1058, 1276], '(2003)': [1060, 1278], 'Antimicrobiol.': [1061, 1279], 'Chemother.,': [1063, 1281], 'pressGoogle': [1065, 1283], 'In': [1067, 3274, 3298, 3615, 3850, 3937, 4082, 4474], 'addition,': [1068, 1665], 'can': [1072, 3252], 'easily': [1073], 'purified,': [1075], 'crystal': [1078, 3100, 4407], 'available': [1081], '(16Hunte': [1082, 2285, 2805], 'C.': [1083, 1087, 2286, 2290, 2806, 2810], 'Koepke': [1084, 2287, 2807], 'Lange': [1086, 2289, 2809], 'Rossmanith': [1088, 2291, 2811], 'Mitchel': [1090, 2293, 2813], 'H.': [1091, 2294, 2720, 2814], 'Structure.': [1092, 2295, 2815], '8:': [1094, 2297, 2817], '669-684Abstract': [1095, 2298, 2818], 'Full': [1096, 1098, 1310, 1312, 1735, 1737, 2014, 2016, 2299, 2301, 2748, 2750, 2819, 2821, 2857, 3393, 3395, 3417, 3456, 3651, 3715, 3896, 3898, 3931, 4039], 'Text': [1097, 1099, 1311, 1313, 1736, 1738, 2015, 2017, 2300, 2302, 2749, 2751, 2820, 2822, 2858, 3394, 3396, 3418, 3457, 3652, 3716, 3897, 3899, 3932, 4040], 'PDF': [1100, 1314, 1739, 2018, 2303, 2752, 2823, 2859, 3397, 3419, 3458, 3653, 3717, 3900, 3933, 4041], '(508)': [1103, 2306, 2826], 'Scholar).In': [1105], 'current': [1107], 'study,': [1108], 'we': [1109, 1127, 2873, 2920], 'characterized': [1111], 'Based': [1123], 'results,': [1126], 'developed': [1129], 'describes': [1133], 'basis': [1136, 1155, 2150, 2157, 2183, 2894, 2914], 'also': [1152, 2830, 3808, 3907, 4280, 4457], 'explains': [1153], 'efficacy': [1159], 'complexes': [1169, 1288], 'atovaquone.EXPERIMENTAL': [1171], 'PROCEDURESMaterials—Yeast': [1172], 'extract': [1173], 'peptone': [1175], 'were': [1176, 1210, 1237, 1289, 1429, 1465, 1495, 1545, 1624, 1640, 1647, 1701, 1838, 1879, 1889, 1904, 1946, 1955, 2072, 2322, 2348, 2384, 2546, 2673, 3608], 'Difco.': [1178], 'Nitrogen': [1179], 'base': [1180], 'without': [1181, 1663, 3503, 3748], 'amino': [1182], 'acids': [1183], 'but': [1184], 'ammonium': [1186], 'sulfate': [1187], 'U.S.': [1190], 'Biological.': [1191], 'Dodecylmaltoside': [1192], 'obtained': [1194, 1202, 2218, 3872], 'Roche': [1196], 'Applied': [1197], 'Science.': [1198], 'DEAE-Biogel': [1199], 'Bio-Rad.': [1204], 'Diisopropylfluorophosphate,': [1205], 'decyl': [1206], 'ubiquinone,': [1207], 'dithionite': [1209], 'purchased': [1211, 1216], 'Sigma.': [1213], 'Stigmatellin': [1214], 'Fluka': [1218], 'Biochemica.': [1219], 'gift': [1223], 'Glaxo-Wellcome.Purification': [1225], 'Cytochrome': [1227, 1285, 4207], 'Complexes—Wild': [1230], 'type': [1231, 3151], 'mutant': [1236, 2679, 2690], 'grown': [1238], 'extract/peptone/dextrose': [1241], 'medium': [1242], 'harvested': [1244], 'centrifugation.': [1246], 'biolistic': [1259], 'transformation': [1260], 'described': [1262, 1298, 2186], 'elsewhere': [1263, 2187], 'heart': [1295, 3914], 'mitochondria': [1296], 'previously': [1299, 3871], '(17Snyder': [1300], 'C.H.': [1301, 1724, 2003, 3885], 'Trumpower': [1302, 1727, 2006, 2849, 3409, 3643, 3888, 3923, 4031], 'Biol.': [1305, 1730, 2009, 2743, 2852, 3388, 3412, 3451, 3646, 3710, 3891, 3926, 4034, 4465], '274:': [1308], '31209-31216Abstract': [1309], '(29)': [1317], '18Ljungdahl': [1320], 'P.O.': [1321], 'Pennoyer': [1322], 'J.D.': [1323], 'Robertson': [1324], 'Trumower': [1326], 'Biochim.': [1328, 3431, 3690], 'Biophys.': [1329, 3432, 3691], 'Acta.': [1330, 3433, 3692], '1987;': [1331], '891:': [1332], '227-242Crossref': [1333], '(125)': [1336], 'concentrated': [1340], 'centrifugal': [1342], 'filtration,': [1343], 'using': [1344, 1469, 1570, 2095, 2116, 2140, 2163, 2247, 2476, 2554, 2611, 2694, 3156, 4067], 'Amicon®': [1345], 'Centriprep': [1346], 'YM-30': [1347], 'filtration': [1348], 'tubes.Ubiquinol-Cytochrome': [1349], 'Reductase': [1351], 'Activity': [1352], 'Measurements—Cytochrome': [1353], 'reductase': [1355, 3183, 3280, 3317], 'assayed': [1358], '50': [1360, 1605, 3194, 3206], 'mm': [1361, 1367, 1370, 1373, 1376, 1603, 1606, 1610, 1614, 1628], 'potassium': [1362, 1607, 1795], 'phosphate,': [1363, 1608], 'pH': [1364, 1620], '7.0,': [1365], '250': [1366, 1602, 2452], 'sucrose,': [1368, 1604], '0.2': [1369, 1613], 'EDTA,': [1371, 1615], 'NaN3,': [1374], '2.5': [1375, 1397, 3191], 'KCN,': [1377], '0.01%': [1378, 1617], 'Tween': [1379, 1618], '20,': [1380, 1619], '40': [1382, 3339], 'μm': [1383, 1597, 1716, 3240], '23': [1387], '°C.': [1388], 'diluted': [1395, 1594], 'nm': [1398, 1459, 1945, 1978, 2060, 3192, 3260, 3335, 3340], 'assay': [1401, 1434], 'buffer,': [1402, 1435], 'reaction': [1405, 1438], 'started': [1407, 1440], 'adding': [1409, 1442], '2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol,': [1410], 'analogue': [1412], 'ubiquinol.': [1414], 'To': [1415], 'determine': [1416], 'activities': [1417], 'presence': [1420, 3292, 3756, 3766, 3939], 'various': [1422], 'concentrations': [1423, 3189], 'atovaquone,': [1425, 2634, 3758, 3941, 4326], 'inhibitor': [1426, 1494, 2734, 2888, 3200, 3231, 3798], 'substrate': [1428, 3188, 3216, 3323], 'mixed': [1430], 'simultaneously': [1431], 'enzyme.': [1443, 2891, 3234], 'Reduction': [1444], 'monitored': [1449, 3837], 'Aminco': [1452], 'DW-2a': [1453], 'spectrophotometer': [1454], '550': [1456], '539': [1458], 'dual': [1461], 'wavelength': [1462, 1958], 'mode.': [1463], 'Data': [1464, 2275, 2944, 3103], 'collected': [1466], 'analyzed': [1468], 'Online': [1471], 'Instrument': [1472], 'Systems': [1473], 'Inc.': [1474], 'computer': [1475], 'interface': [1476], 'software.': [1478], 'Assuming': [1479], 'rapid': [1480], 'equilibrium': [1481], 'substrate,': [1484], 'inhibitor,': [1486, 3250, 3302, 3749], 'competitive': [1493, 2733, 2887, 3230, 3263], 'calculated': [1496, 2094, 2983], 'measured': [1499, 3289, 3326], 'IC50': [1500, 3204], 'following': [1504], 'formula': [1505], '(19Cheng': [1506], 'Y.C.': [1507], 'Prusoff': [1508], 'W.H.': [1509], '1973;': [1512], '22:': [1513], '3099-30108Crossref': [1514], '(12187)': [1517], 'Ki=IC501+[S]Km(Eq.': [1520], '1)': [1521], '1The': [1523], 'abbreviations': [1524], 'are:': [1526], 'EPR,': [1527], 'paramagnetic': [1529], 'resonance;': [1530], 'OTTLE,': [1531], 'optically': [1532], 'transparent': [1533], 'thin': [1534], 'layer': [1535], 'electrode;': [1536], 'UHDBT,': [1537, 3359, 3997], '3-undecyl-2-hydroxy-1,4-benzoxythiazole;': [1538], 'HDBT,': [1539], '2-hydroxy-1,4-benzoxythiazole;': [1540], 'NHDBT,': [1541], '3-nonyl-2-hydroxy-1,4-benzoxythiazole.': [1542], 'Spectroscopy—EPR': [1543], 'spectra': [1544, 1674, 1697, 1873, 3486], 'recorded': [1546], 'temperature': [1549, 2394, 2405], '20': [1551, 1650, 3334], 'K,': [1552, 2391], 'microwave': [1553, 1558], 'frequency': [1554], '9.47': [1556], 'GHz,': [1557], 'power': [1559], 'milliwatt,': [1562], 'modulation': [1565], 'amplitude': [1566, 1953, 2027], '0.64': [1568], 'millitesla': [1569], 'Bruker': [1572], 'ESP': [1573], '300E': [1574], 'spectrometer': [1575], 'equipped': [1576], 'liquid': [1579], 'helium': [1580], 'continuous': [1581], 'flow': [1582], 'cryostat,': [1583], 'ESR': [1584], '900,': [1585], 'Oxford': [1587], 'Instruments.': [1588], '24': [1596], 'buffer': [1600], 'containing': [1601], 'sodium': [1611], 'azide,': [1612], '7.0.': [1621], 'samples': [1623, 1646], 'reduced': [1625, 1968, 1991], '5': [1627], 'ascorbate.': [1629], 'After': [1630, 2456], 'reduction,': [1631], '3': [1632], 'eq': [1633], '(72': [1636], 'μm)': [1637], 'or': [1638, 2320, 4412], 'stigmatellin': [1639, 2568, 2896, 2932, 2941, 2990, 3091, 3607, 4098], 'added': [1641, 1807, 1890], 'when': [1642, 1981, 3982], 'indicated,': [1643], 'incubated': [1648], 'min': [1651], 'ice.': [1653], 'For': [1654], 'base-line': [1655], 'correction,': [1656], 'sample': [1658], 'any': [1664, 4172], 'representing': [1666], 'oxidized': [1668, 1985], 'state,': [1669], 'subtracted': [1671], 'ascorbate-reduced': [1676, 3512], 'samples.': [1677], 'estimate': [1679], 'deviations': [1682], 'gz': [1684, 3518, 3534, 3541, 3792], 'gy': [1686, 3521, 3550, 3556, 3573], '±0.001,': [1688], 'gx': [1692, 3525, 3536, 3545, 3613], '±0.005': [1694], 'shown.Potentiometric': [1698], 'Titrations—The': [1699], 'titrations': [1700, 3861], 'performed': [1702], 'CD': [1704, 1930, 1973, 2045, 2056, 3839], 'spectroscopy': [1705, 3840], 'OTTLE': [1708], 'path': [1712], 'length': [1713], '(20Denke': [1717, 3878], 'Merbitz-Zahradnik': [1719, 1998, 3880], 'Hatzfeld': [1721, 2000, 3882], 'O.M.': [1722, 2001, 3883], 'Snyder': [1723, 2002, 3884], 'Link': [1725, 2004, 3886], 'T.A.': [1726, 2005, 3887], '273:': [1733, 2012, 3894], '9085-9093Abstract': [1734, 2013, 3895], '(147)': [1742, 2021, 3903], 'concentration': [1746, 1844, 3217, 3324], 'least': [1753], '300': [1754], 'μm.': [1755, 1847], 'mixture': [1757], 'redox': [1759, 1864, 3844], 'mediators': [1760, 1823], 'benzyl': [1762], 'viologen': [1763], '(–358': [1764], 'mV),': [1765, 1768, 1771, 1774, 1777, 1781, 1785, 1788, 1791, 1794, 1798], 'anthraquinone-2-sulfonate': [1766], '(–225': [1767], '2-hydroxy-1,4-naphthoquinone': [1769], '(–152': [1770], 'menadione': [1772], '(–13': [1773], 'duroquinone': [1775], '(5': [1776], 'phenazine': [1778, 1782], 'ethosulfate': [1779], '(55': [1780], 'methosulfate': [1783], '(80': [1784], 'trimethyl-1,4-benzoquinone': [1786], '(99': [1787], '1,2-naphthoquinone': [1789], '(144': [1790], 'tetramethyl-p-phenyldiamine': [1792], '(276': [1793], 'hexacyanoferrate': [1796], '(408': [1797], 'ferrocene-1,1′-dicarboxylic': [1800], 'acid': [1801, 4439], '(530': [1802], '644': [1804], 'mV)': [1805], 'facilitate': [1809], 'equilibration': [1810], 'electrode': [1813], 'potentials': [1814], '(numbers': [1815], 'brackets': [1817], 'E': [1819], 'm7': [1820], 'mV).': [1825], 'mediators,': [1827], 'spanned': [1829], 'range': [1832], '–358': [1834], '+644': [1836], 'all': [1839], 'final': [1843, 2458, 2471, 2562, 2682], '20–25': [1846], 'Equilibration': [1848], 'applied': [1854, 3843], 'confirmed': [1857], 'repetitive': [1859], 'scan': [1860, 1908], 'monitoring': [1861], 'state': [1865], 'entire': [1868], 'Only': [1872], 'completely': [1876], 'equilibrated': [1877], 'data': [1882, 3659, 3961], 'analysis.': [1883], 'inhibitors': [1885, 2842, 2994, 3069, 3112], 'NHDBT': [1886], '3-fold': [1892], 'molar': [1893], 'excess.': [1894], 'Four': [1895], 'scans': [1896], 'each': [1901, 1949, 2386, 2439, 2446, 2549, 2685, 3125], 'value': [1903, 3237, 3564, 3866, 3966], 'accumulated': [1905], 'speed': [1909], '200': [1911], 'nm/min,': [1912], '2-nm': [1913], 'bandwidth,': [1914], 'integration': [1917], 'time': [1918, 2399, 2426], '4': [1920, 4397], 's.': [1921], 'From': [1922, 2024, 3208], 'resulting': [1924], 'spectrum,': [1925, 1950, 1993], 'amplitudes': [1927, 2053], 'signal': [1931, 1974, 2046], 'five': [1933, 2393], 'wavelengths': [1934], '(494,': [1935], '498,': [1936], '500,': [1937], '502,': [1938], '505': [1940], 'centering': [1942, 1975], 'around': [1943, 1976, 4137, 4151], '500': [1944, 1977, 2059], 'extracted': [1947, 2933], 'averaged.': [1956], 'monitor': [1962], 'potentiometric': [1964], 'titration,': [1965], 'since': [1966, 4171], 'disappears': [1980], 'cluster': [1983, 3829, 3949, 4227], '(for': [1986], 'example': [1988], 'see': [1994], 'Ref.': [1995, 4458], '20Denke': [1996], 'total': [2026], 'change,': [2028], 'degree': [2030], 'reduction': [2032, 2040, 3824], 'calculated.': [2038], 'Complete': [2039], 'refers': [2041], 'negative': [2044], 'intensity': [2047], 'signals': [2057, 3516, 3537, 3793], 'indicated': [2062, 3776], 'legend': [2065], 'Fig.': [2067, 2918, 3173, 3509, 4080], '4.': [2068], 'curves': [2071], 'fitted': [2073], 'Nernstian': [2075], 'functions': [2076], 'assuming': [2077], 'n': [2079], 'transition.Molecular': [2083], 'Modeling—Atovaquone': [2084], 'built': [2086, 2603], 'silico': [2088], 'conformation': [2092, 2214, 3082, 4126], 'MacSpartan': [2096], 'Pro®': [2097], '(Wavefunction,': [2098], 'Inc.,': [2099, 2207, 2259, 2528], 'Irvine,': [2100, 2208], 'CA).': [2101, 2262], 'initial': [2103, 3213, 3319], 'submitted': [2106, 2129], 'conformational': [2109, 4166], 'profile': [2111], 'determination': [2112], 'mechanics': [2115, 2161], 'MMFF': [2118, 2165], 'function': [2119], 'program.': [2122], 'lowest': [2124, 2435, 2464, 2543, 4124], 'conformer': [2126], 'then': [2128], 'more': [2132, 3609, 3980], 'refined': [2133], 'minimization': [2135, 2450], 'same': [2138, 2556, 2657, 2701, 3018, 3594, 3626], 'program': [2139], 'Hartree-Fock': [2142, 2170], 'orbital': [2144], 'method': [2145, 2407, 2480], '3–21': [2148, 2179], 'G': [2149, 2180], 'set': [2151, 2377, 2557], 'calculation.': [2154], 'theoretical': [2156], 'calculations': [2162], 'force': [2166, 2697], 'field': [2167, 2698], 'quantum': [2171], 'mechanical': [2172], 'calculations,': [2173, 2372], 'split': [2181], 'valence': [2182], 'set,': [2184], '(21Hehre': [2188], 'W.J.': [2189], 'Yu': [2190], 'Klunzinger': [2192], 'P.E.': [2193], 'Lou': [2194], 'Brief': [2197], 'Guide': [2198], 'Molecular': [2200], 'Mechanics': [2201], 'Quantum': [2203], 'Chemical': [2204], 'Calculations.': [2205], 'Wavefunction,': [2206], 'CA1998:': [2209], '7-35Google': [2210], 'thus': [2217, 2905, 3478], 'starting': [2223, 2264, 2908], 'point': [2224, 2909], 'modeling': [2226, 2236, 2662], 'ligand': [2228, 4110], 'complex.Molecular': [2235], 'carried': [2238, 2674], 'out': [2239, 2675], 'Silicon': [2242], 'Graphics': [2243], 'O2': [2244], 'work': [2245], 'station': [2246], 'Discover': [2249, 2485], '3®': [2250, 2486], 'module': [2251, 2487], 'within': [2252, 2314, 2488], 'Insight': [2254, 2490], 'II®': [2255, 2491], 'software': [2256], 'package': [2257], '(Accelrys': [2258], 'San': [2260], 'Diego,': [2261], 'stigmatellin-liganded': [2268], '(Protein': [2274, 2943, 3102], 'Bank': [2276, 2945, 3104], 'code': [2277, 2946, 3105], '1EZV)': [2278], 'resolution': [2281, 4414], '2.30': [2283], 'Å': [2284, 2316, 4094, 4411], 'residues': [2313, 2332, 2347, 2702, 4440], '4.0': [2315], 'either': [2318], 'Glu272': [2321, 2584, 2789, 4271, 4301, 4329, 4387], 'allowed': [2323, 2641], 'flexible.': [2326], 'surrounding': [2328, 2631], '9.5-Å': [2329, 2362, 2630], 'shell': [2330], 'both': [2334, 3052], 'fixed,': [2342], 'most': [2345], 'distant': [2346], 'excluded': [2349], 'calculation': [2352], 'obtain': [2356, 4104], 'manageable': [2358], 'simulation': [2359, 2398], 'speed.': [2360], 'atom-based': [2363], 'cut-off': [2364], 'nonbonding': [2366], 'interactions': [2367], 'during': [2370], 'dielectric': [2375], 'constant': [2376], '2.0.': [2379], 'Eight': [2380], 'simulated': [2381, 2670], 'annealing': [2382, 2671], 'runs': [2383, 2672, 2691], 'performed,': [2385], '800': [2388], '298': [2390], 'steps': [2395], '5000': [2401], 'fs/step.': [2402], 'Nosé': [2404], 'control': [2406, 3781], '(22Nose': [2408], 'Phys.': [2412], '1984;': [2413, 2723], '81:': [2414], '511-519Crossref': [2415], '(12165)': [2417], '0.5': [2424], 'fs/iteration': [2425], 'step.A': [2427], 'custom': [2428], 'macro': [2429], 'written': [2431], 'select': [2433], 'dynamics': [2440, 2447], 'run': [2441], 'continued': [2443], 'modeling.': [2444], 'Between': [2445], 'run,': [2448], 'iterations': [2453], 'performed.': [2455], 'round': [2459], 'dynamics,': [2462], 'minimized': [2468, 2538, 4109], 'convergence': [2472], 'criterion': [2473], '0.001,': [2475], "Cauchy's": [2477], 'steepest': [2478], 'descent': [2479], 'implemented': [2482], 'software,': [2492], 'followed': [2493], 'conjugate': [2495], 'gradient': [2496], '(23Jacobs': [2497], 'D.A.H.': [2498], 'State': [2500], 'Art': [2503], 'Numerical': [2505], 'Analysis.': [2506], 'Academic': [2507, 2526], 'Press,': [2508, 2527], 'London1977:': [2509], '256-258Google': [2510], 'Newton': [2513], '(Broyden,': [2514], 'Fletcher,': [2515], 'Goldfarb,': [2516], 'Shand)': [2518], 'methods': [2519], '(24Fletcher': [2520], 'Practical': [2522], 'Methods': [2523], 'Optimization.': [2525], 'New': [2529], 'York1987:': [2530], '54-57Google': [2531], 'succession.': [2534], 'Of': [2535], 'eight': [2537], 'obtained,': [2540], 'three': [2542], 'structures': [2545, 3065, 4408], 'chosen,': [2547], 'modeled': [2551, 2606], 'again': [2552], 'twice,': [2553], 'parameters.': [2559], 'Overlaying': [2560], 'atovaquone-bound': [2563, 2607], 'original': [2567], 'showed': [2570, 3552], 'minimal': [2572, 2639], 'amount': [2573], 'backbone': [2575], 'shifting': [2576], 'and,': [2577, 2836], 'exception': [2580], 'rotated': [2583, 2963, 3120], 'side': [2585, 3044, 4379, 4435], 'chain,': [2586], 'just': [2587], 'enough': [2588], 'side-chain': [2589], 'movement': [2590], 'accommodate': [2592], 'chloro-benzyl': [2594], 'tail': [2595], 'atovaquone.The': [2597], 'center': [2608, 2766, 3370, 3491, 3514, 3742, 3985, 4065, 4199], 'P': [2609, 2767, 3371, 4066, 4200], 'site': [2610], 'Biopolymer®': [2613], 'module.': [2614], 'flexible': [2616], 'subset': [2617], 'defined': [2619], '2.0-Å': [2622], 'radius': [2623], 'mutated': [2626], 'residue': [2627], 'L275F.': [2628], 'radius,': [2632], 'kept': [2636], 'fixed.': [2637], 'flexibility': [2640], 'evaluation': [2642], 'cost': [2646, 4184], 'binding.': [2654], 'Using': [2655, 3235], 'procedure': [2658], 'wild-type': [2667, 2706], 'structure,': [2668, 2991, 4084], 'four': [2669, 2688], 'structure.': [2680], 'evaluated': [2693], 'CFF91': [2696], 'runs.RESULTSStructural': [2707], 'Similarities': [2708], 'Stigmatellin—Stigmatellin': [2712], '(25Kunze': [2713], 'Kemmer': [2715], 'Höfle': [2717], 'G.': [2718, 3464], 'Reichenbach': [2719], 'Antibiot.': [2722], '37:': [2724], '454Crossref': [2725], '(26Covian': [2735, 3380], 'R': [2736, 3381], 'Pardon': [2737, 3382], 'Moreno': [2739, 3384], 'Sanchez': [2740, 3385], '2002;': [2745, 3390], '277:': [2746, 3391], '48449-48455Abstract': [2747, 3392], '(14)': [2755, 3400], 'Its': [2773], 'benzopyranone': [2774, 3040], 'ring': [2775, 2969, 3003, 3035, 4087, 4099, 4119, 4133, 4147, 4309, 4317, 4382], 'system': [2776, 4100], 'via': [2784, 2794, 4363], 'hydroxyl': [2786, 4357], 'group': [2787, 2797, 4358, 4394, 4455], 'carbonyl': [2796, 4393], 'His181': [2799, 4286, 4371], 'analogy': [2838], 'other': [2840], 'hydroxyquinone': [2841, 3034], '(27Bowyer': [2843, 3637, 3917, 4025], 'J.R.': [2844, 3404, 3424, 3445, 3638, 3683, 3704, 3918, 4026], 'Edwards': [2845, 3405, 3639, 3919, 4027], 'C.A.': [2846, 3406, 3640, 3920, 4028], 'Ohnishi': [2847, 3407, 3446, 3465, 3641, 3705, 3921, 4029], '1982;': [2854, 3414, 3648, 3928, 4036], '257:': [2855, 3415, 3649, 3929, 4037], '8321-8330Abstract': [2856, 3416, 3650, 3930, 4038], 'presumed': [2864], 'bind': [2866], 'pocket.': [2871, 4113, 4268], 'Below,': [2872, 3075], 'show': [2874], 'this': [2876, 3168, 3480, 3965, 4083], 'presumption': [2877], 'correct': [2879], 'that,': [2881], 'like': [2882], 'stigmatellin,': [2883, 3042, 3602], 'useful': [2907], 'elucidate': [2911], 'binding.In': [2917], 'compared': [2922, 4121], 'bound': [2942, 3504, 3668, 4294], '1EZV).': [2947, 3106], 'one': [2954, 3009, 3251, 3581], 'hydroxynaphthoquinone': [2958, 3667, 4308, 4361], 'chlorophenyl': [2960, 4146, 4316], 'rings': [2961, 3049], '90°': [2964], 'relative': [2965], 'cyclohexyl': [2968, 4132, 4156], 'links': [2971], 'them,': [2972], 'latter': [2975], 'chair': [2979], 'conformation.': [2980], 'superposed': [2987], 'display': [2995], 'alignment': [3000], 'their': [3002], 'systems': [3004], '(Fig.': [3005, 3848], '1).': [3006], 'indication': [3010], 'molecules': [3014], 'probably': [3015], 'share': [3016], 'mode': [3020], 'Although': [3026], 'some': [3029], 'similarity': [3031], 'chains': [3045, 4436], 'extending': [3046, 4251], 'differ': [3050], 'significantly,': [3051], 'spatial': [3057], 'conformation.Fig.': [3058], '1Structures': [3059], 'stigmatellin.': [3063, 3768], 'shown': [3071, 3079, 3116, 3171, 3507, 4078, 4210, 4222, 4250, 4261], 'top.': [3074], 'color,': [3077], '(in': [3085, 3092], 'yellow)': [3086], 'green)': [3093], 'appears': [3096], 'At': [3107], 'bottom,': [3109], 'superimposed': [3114], 'views,': [3119], '∼90°': [3121], 'respect': [3123], 'other.View': [3126], 'Large': [3127, 3343, 3800, 4348], 'Image': [3128, 3344, 3801, 4349], 'Figure': [3129, 3345, 3802, 4350], 'ViewerDownload': [3130, 3346, 3803, 4351], 'Hi-res': [3131, 3347, 3804, 4352], 'image': [3132, 3348, 3805, 4353], 'Download': [3133, 3349, 3806, 4354], '(PPT)Atovaquone': [3134], 'Is': [3135], 'Competitive': [3137], 'Inhibitor': [3138], 'Complex—': [3143], 'Inhibition': [3144], 'measured,': [3148], 'determined': [3155, 3241, 3858], 'purified': [3161, 3283, 3494], 'yeast.': [3164], '2.': [3174], 'Under': [3175], 'usual': [3177], 'conditions': [3178], 'assay,': [3184], 'μm,': [3195], 'respectively,': [3196], 'titration': [3197], 'nm.': [3207], 'reciprocal': [3210, 3312], 'plots': [3211, 3313], 'velocity': [3214, 3320], 'different': [3219], 'concentrations,': [3221], 'evident': [3224], '11': [3239], 'm': [3245], 'absence': [3248, 3300, 3329, 3852], 'calculate': [3253], 'inhibitor.Fig.': [3264], '2Inhibition': [3265], 'left': [3276], 'panel': [3277, 3310], 'varying': [3294], 'amounts': [3295], 'cat': [3304], '130': [3306], 's–1.': [3307], 'right': [3309], 'shows': [3311], '(1/s–1)': [3321], '(1/μm)': [3325], '(diamonds),': [3332], '(squares)': [3336], '(circles)': [3341], 'atovaquone.View': [3342], '(PPT)Interaction': [3350], 'Iron-Sulfur': [3356], 'Protein—Stigmatellin': [3357], 'alkyl-hydroxybenzoxythiazole,': [3361], 'interact': [3362], '27Bowyer': [3403], '28Bowyer': [3423], 'Dutton': [3425, 3448, 3684, 3707], 'P.L.': [3426, 3449, 3685, 3708], 'Prince': [3427, 3686], 'R.C.': [3428, 3687], 'Crofts': [3429, 3688], 'A.R.': [3430, 3689], '1980;': [3434, 3693], '592:': [3435, 3694], '445-460Crossref': [3436, 3695], '(109)': [3439, 3698], '29Matsuura': [3442, 3701], 'Bowyer': [3444, 3703], '1983;': [3453, 3712], '258:': [3454, 3713], '1571-1579Abstract': [3455, 3714], '30von': [3462], 'Jagow': [3463], 'FEBS': [3467], 'Lett.': [3468], '1985;': [3469], '185:': [3470], '311-315Crossref': [3471], '(145)': [3474], 'possible': [3481], '3.': [3510], 'revealed': [3515], '2.028,': [3520], '1.899,': [3523], '1.75.': [3527], 'addition': [3529], 'shifted': [3532], 'higher': [3539], 'field,': [3540], '2.034': [3543], '1.76,': [3547], 'whereas': [3548], 'component': [3551], 'lower': [3554, 4231], 'value,': [3555], '1.888.': [3558], 'shift': [3560], '0.01,': [3566], 'case': [3570], 'signal,': [3574], '∼21': [3576], 'Gauss.': [3577], 'corresponds': [3579], 'times': [3582], 'complete': [3584], 'line': [3585], 'width': [3586], 'signal.': [3589], 'had': [3591], 'almost': [3592, 3624], 'although': [3603], 'pronounced': [3610], 'region.': [3614], 'UHDBT': [3621, 4014], 'resulted': [3622], 'observed': [3630], 'similar': [3661, 4009], 'published': [3664], 'photosynthetic': [3680], 'bacteria': [3681], '(28Bowyer': [3682], 'Scholar).Fig.': [3720], '3Effect': [3721], 'cluster.': [3733, 3822], 'top': [3735], 'middle': [3751], 'bottom': [3761, 4264], 'dashed': [3770], 'lines': [3771], 'drawn': [3773], 'through': [3774, 4302], 'resonance': [3777], 'peaks': [3778], 'emphasize': [3784], 'gx,': [3789], 'gy,': [3790], 'result': [3796], 'binding.View': [3799], '(PPT)We': [3807], 'tested': [3809], 'effect': [3811, 4012], 'status': [3825], 'varied': [3847], '4).': [3849], 'inhibitors,': [3854], 'mV.': [3864, 3955, 3973], 'identical': [3868, 3908], 'increased': [3950, 4001, 4183], 'Due': [3956], 'scatter': [3958], 'low': [3963, 3970, 4449], 'potentials,': [3964], 'may': [3967], '370': [3972], 'indicates': [3975, 4432], '∼50-fold': [3979], 'tightly': [3981], 'reduced.': [3987], 'By': [3988], 'way': [3989], 'comparison,': [3991], 'nonyl-HDBT,': [3993], 'analog': [3995], '350': [4005], '±': [4006], '12': [4007], 'Scholar).Docking': [4044], 'Yeast': [4049], 'Complex—An': [4052], 'docked': [4058], 'coordinates': [4069], '5.': [4081], 'naphthoquinone': [4086, 4118, 4142], 'positioned': [4092], '2.6': [4093], 'deeper': [4095], 'than': [4096], 'maximum': [4105], 'As': [4114], 'viewed': [4115], 'unbound': [4129], 'form,': [4130], 'rotates': [4134, 4148], '47°': [4135], 'clockwise': [4136, 4150], 'bond': [4139, 4153, 4366], 'ring,': [4143], '32°': [4149], 'ring.': [4157, 4401], 'rotational': [4159], 'changes': [4160], 'involve': [4161], 'very': [4162], 'little': [4163], 'change': [4164, 4174], 'energy,': [4167], 'reasonable,': [4170], 'such': [4173], 'would': [4175], 'compensated': [4179], 'energy.Fig.': [4187], '5Energy-minimized': [4188], 'cyan,': [4212], 'portion': [4215], 'gold.': [4224], 'left,': [4232], 'iron': [4234], 'sulfur': [4236], 'atoms': [4237, 4324, 4333, 4337, 4342], 'colored': [4238], 'purple': [4239], 'yellow,': [4241], 'respectively.': [4242], 'C': [4244], 'helix': [4245, 4259], 'vertically': [4252], 'right,': [4255], 'cd1': [4258], 'Leu275': [4269, 4345], 'ef': [4274], 'loop': [4275], 'shown.': [4281], 'hydrogen-bonded': [4284], 'water': [4295], 'forms': [4297], 'bridge': [4299], 'second': [4304], 'hydrogen': [4305, 4341, 4365], 'bond.': [4306], 'toward': [4311], 'front,': [4313], 'extends': [4318], 'rear.': [4321], 'carbon': [4323], 'His181,': [4327], 'green,': [4331], 'oxygen': [4332], 'red,': [4335], 'nitrogen': [4336, 4369], 'blue,': [4339], 'white.': [4344], 'purple.View': [4347], '(PPT)Notably,': [4355], 'On': [4376], 'opposite': [4378], 'system,': [4383], 'quinone': [4400], 'survey': [4403], '∼60': [4405], '2.0': [4410], 'better': [4413], 'Atlas': [4417], 'Side-chain': [4419], 'Main-chain': [4421], 'Hydrogen': [4422], 'Bonds': [4423], '(available': [4424], 'World': [4427], 'Wide': [4428], 'Web': [4429], 'www.biochem.ucl.ac.uk/~mcdonald/atlas/glu.html)': [4431], 'glutamic': [4438], 'usually': [4442], 'not': [4443], 'proton': [4444], 'donors,': [4445], 'due': [4446], 'pK': [4450], 'carboxyl': [4454], '(see': [4456], '31McDonald': [4459], 'E.K.': [4460], 'Thornton': [4461], '238:': [4467], '777-793Crossref': [4468], '(1860)': [4471], 'few': [4476], 'cases': [4477], '(32Maroti': [4478]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2122838518', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-17T13:04:58.212271', 'created_date': '2016-06-24'}