Toll‐like receptor 9 protects non‐immune cells from stress by modulating mitochondrial <scp>ATP</scp> synthesis through the inhibition of <scp>SERCA</scp> 2

Name: Work Video:
Duration: 3 min 30 s
Yasunori Shintani; Hannes C. A. Drexler; Hidetaka Kioka; Cesare M. Terracciano; Steven R. Coppen; Hiromi Imamura; Masaharu Akao; Junichi Nakai; Ann P. Wheeler; Shuichiro Higo; Hiroyuki Nakayama; Seiji Takashima; Kenta Yashiro; Ken Suzuki
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230, 351, 472, 649, 770, 922, 1007, 4605], 'Biochemistry,': [54, 352, 473, 771, 923], 'Osaka': [55, 102, 304, 329, 353, 365, 474, 521, 723, 748, 772, 784, 924, 947, 1048], 'Graduate': [57, 104, 194, 306, 331, 355, 367, 476, 523, 613, 725, 750, 774, 786, 926, 949, 982, 1050], 'Medicine,': [60, 101, 107, 133, 303, 309, 358, 364, 370, 479, 520, 526, 552, 722, 728, 777, 783, 789, 929, 946, 952, 965], 'Suita,': [61, 108, 310, 359, 371, 480, 527, 729, 778, 790, 930, 953], 'Japan': [62, 109, 211, 233, 252, 311, 337, 360, 372, 481, 528, 630, 652, 671, 730, 756, 779, 791, 931, 954, 999, 1010, 1018, 1056], 'Search': [63, 87, 110, 146, 179, 212, 234, 253, 289, 312, 338, 373, 404, 437, 482, 506, 529, 565, 598, 631, 653, 672, 708, 731, 757, 792, 823, 856], 'for': [64, 82, 88, 111, 129, 147, 180, 213, 235, 254, 290, 313, 339, 374, 405, 438, 483, 501, 507, 530, 548, 566, 599, 632, 654, 673, 709, 732, 758, 793, 824, 857, 938, 961, 1212, 1310, 1398, 1448, 1538, 1665, 1727, 1751, 1922, 1927, 1987, 2046, 2178, 2183, 2665, 2715, 2743, 2748, 2754, 2760, 2766, 3097, 3236, 3263, 3410, 3557, 3562, 3568, 3705, 3820, 3897, 3947, 4330, 4415, 4436, 4486, 4553, 4561, 4578, 4914, 5428, 5503], 'more': [65, 89, 112, 148, 181, 214, 236, 255, 291, 314, 340, 375, 406, 439, 484, 508, 531, 567, 600, 633, 655, 674, 710, 733, 759, 794, 825, 858], 'papers': [66, 90, 113, 149, 182, 215, 237, 256, 292, 315, 341, 376, 407, 440, 485, 509, 532, 568, 601, 634, 656, 675, 711, 734, 760, 795, 826, 859], 'this': [68, 92, 115, 151, 184, 217, 239, 258, 294, 317, 343, 378, 409, 442, 487, 511, 534, 570, 603, 636, 658, 677, 713, 736, 762, 797, 828, 861, 1575, 1706, 1807, 1821, 1923, 2179, 2247, 2744, 3034, 3558, 3622, 3695, 3804, 4249, 4565, 5552], 'author': [69, 93, 116, 152, 185, 218, 240, 259, 295, 318, 344, 379, 410, 443, 488, 512, 535, 571, 604, 637, 659, 678, 714, 737, 763, 798, 829, 862, 1106], 'Hannes': [70, 73, 489, 492, 868], 'CA': [71, 74, 490, 493, 869], 'Drexler': [72, 75, 491, 494], 'Bioanalytical': [76, 495], 'Mass': [77, 496, 933, 1817], 'Spectrometry,': [78, 497, 934], 'Max': [79, 498, 935], 'Planck': [80, 499, 936], 'Institute': [81, 500, 937], 'Molecular': [83, 502, 939], 'Biomedicine,': [84, 328, 503, 747, 940, 1047], 'Muenster,': [85, 504, 941], 'Germany': [86, 505, 942], 'Hidetaka': [94, 96, 513, 515, 871], 'Kioka': [95, 97, 514, 516, 5335], 'Cardiovascular': [100, 302, 363, 519, 721, 782, 945], 'Cesare': [117, 120, 536, 539, 873], 'MN': [118, 121, 537, 540, 874], 'Terracciano': [119, 122, 538, 541], 'Laboratory': [123, 206, 323, 542, 625, 742, 994], 'Myocardial': [125, 544, 957], 'Electrophysiology,': [126, 545, 958], 'Imperial': [127, 134, 546, 553, 959, 966], 'Centre': [128, 547, 960], 'Translational': [130, 549, 962], 'Experimental': [132, 551, 964], 'College': [135, 554, 967], 'National': [137, 226, 556, 645, 969, 1003], 'Heart': [138, 557, 970], '&': [139, 193, 558, 612, 971, 981, 1118], 'Lung': [140, 559, 972], 'Hammersmith': [142, 561, 974], 'Campus,': [143, 201, 562, 620, 975, 989], 'Steven': [153, 156, 572, 575, 876], 'R': [154, 157, 573, 576, 877, 5006, 5456], 'Coppen': [155, 158, 574, 577, 4851], 'Hiromi': [186, 188, 605, 607, 879], 'Imamura': [187, 189, 606, 608, 5292, 5345], 'Hakubi': [191, 610, 979], 'Center': [192, 611, 980], 'Biostudies,': [197, 616, 985], 'Faculty': [198, 617, 986], 'Kyoto': [202, 229, 621, 648, 990, 1006], 'Science': [204, 248, 326, 623, 667, 745, 992, 1014, 1045], 'Frontier': [205, 624, 993], 'building': [207, 626, 995], 'Room': [208, 627, 996], '305,': [209, 628, 997], 'Kyoto,': [210, 232, 629, 651, 998, 1009], 'Masaharu': [219, 221, 638, 640, 881], 'Akao': [220, 222, 639, 641, 5264], 'Cardiology,': [225, 644, 1002], 'Hospital': [227, 646, 1004], 'Organization': [228, 647, 1005], 'Center,': [231, 650, 1008], 'Junichi': [241, 243, 660, 662, 883], 'Nakai': [242, 244, 661, 663, 5254], 'Saitama': [245, 250, 664, 669, 1016], 'Brain': [247, 666, 1013], 'City,': [251, 670, 1017], 'Ann': [260, 263, 679, 682, 885], 'P': [261, 264, 680, 683, 886, 4532, 4713, 5424], 'Wheeler': [262, 265, 681, 684], 'Blizard': [266, 271, 685, 690, 1024], 'Advanced': [267, 686, 1020], 'Light': [268, 687, 1021], 'Microscopy': [269, 688, 1022], 'Facility,': [270, 689, 1023], 'Shuichiro': [296, 298, 715, 717, 888], 'Higo': [297, 299, 716, 718, 5349], 'Hiroyuki': [319, 321, 738, 740, 890], 'Nakayama': [320, 322, 739, 741], 'Clinical': [325, 744, 1044], 'Pharmaceutical': [334, 753, 1053], 'Sciences,': [335, 754, 1054], 'Osaka,': [336, 755, 1055], 'Seiji': [345, 347, 764, 766, 892], 'Takashima': [346, 348, 765, 767, 4590, 4859, 5069], 'Kenta': [380, 382, 799, 801, 894], 'Yashiro': [381, 383, 800, 802], 'Ken': [411, 415, 830, 834, 897], 'Suzuki': [412, 416, 831, 835, 898, 4572, 5343], 'Information': [864, 4681], '1,2,': [867], 'Drexler3,': [870], 'Kioka4,': [872], 'Terracciano5,': [875], 'Coppen1,': [878], 'Imamura6,': [880], 'Akao7,': [882], 'Nakai8,': [884], 'Wheeler9,': [887], 'Higo4,': [889], 'Nakayama10,': [891], 'Takashima2,4,': [893], 'Yashiro1': [895], '1': [899, 1929, 3121, 4399, 4416, 4471], '1William': [900], '2Department': [920], '3Bioanalytical': [932], '4Department': [943], '5Laboratory': [955], '6The': [978], '7Department': [1000], '8Saitama': [1011], '9Blizard': [1019], '10Laboratory': [1042], '*Corresponding': [1057, 1068], 'author.': [1058, 1069], 'Tel:': [1059, 1070], '+81': [1060, 1063], '668793492;': [1061], 'Fax:': [1062, 1073], '668793493;': [1064], 'E-mail:': [1065, 1076], '[email': [1066, 1077], 'protected]': [1067, 1078], '+44': [1071, 1074], '2078828236;': [1072], '2078828256;': [1075], 'EMBO': [1079], 'Reports': [1080], '(2014)15:438-445https://doi.org/10.1002/embr.201337945': [1081], 'PDFDownload': [1082], 'PDF': [1083], 'article': [1085], 'text': [1086], 'main': [1088, 3692], 'figures.': [1089], 'Peer': [1090], 'ReviewDownload': [1091], 'a': [1092, 1126, 1209, 1234, 1307, 1349, 1385, 1535, 1551, 1580, 1678, 1766, 1789, 1836, 1879, 1944, 2000, 2043, 2255, 2297, 2379, 2404, 2866, 2965, 3041, 3046, 3158, 3234, 3280, 3306, 3472, 3580, 3600, 3701, 3781, 3817, 3885, 3944, 4160, 4265, 4345, 4359, 5278, 5369], 'summary': [1093], 'editorial': [1096, 1100], 'decision': [1097, 1101], 'process': [1098], 'including': [1099, 1438, 1604], 'letters,': [1102], 'reviewer': [1103], 'comments': [1104], 'responses': [1107, 1253, 1542, 3951, 4275], 'to': [1108, 1111, 1175, 1233, 1274, 1478, 1498, 1561, 1563, 1586, 1613, 1620, 1912, 1956, 1966, 1981, 2034, 2122, 2192, 2253, 2453, 2547, 2600, 2632, 2636, 2786, 2854, 2988, 3026, 3074, 3101, 3268, 3430, 3577, 3613, 3670, 3685, 3880, 3930, 3965, 3973, 4039, 4053, 4080, 4094, 4139, 4153, 4197, 4223, 4564, 4609, 4741, 4939, 5100, 5219], 'feedback.': [1109], 'ToolsAdd': [1110], 'favoritesDownload': [1112], 'CitationsTrack': [1113], 'CitationsPermissions': [1114], 'ShareFacebookTwitterLinked': [1115], 'InMendeleyWechatReddit': [1116], 'Figures': [1117], 'Info': [1119], 'Abstract': [1120], '(TLR9)': [1124, 1843, 2052, 2419, 3361], 'has': [1125, 1270, 2798, 3777], 'key': [1127, 1210, 1308, 3235, 3702], 'role': [1128, 2406, 3282, 4953, 5502], 'in': [1129, 1135, 1153, 1168, 1181, 1236, 1257, 1330, 1418, 1426, 1435, 1457, 1482, 1590, 1601, 1649, 1700, 1739, 1795, 1799, 1896, 1915, 1960, 2008, 2020, 2025, 2054, 2068, 2078, 2112, 2120, 2131, 2223, 2265, 2280, 2320, 2351, 2360, 2363, 2372, 2384, 2407, 2412, 2424, 2455, 2505, 2520, 2538, 2562, 2586, 2709, 2792, 2833, 2858, 2861, 2888, 2905, 2998, 3062, 3109, 3134, 3141, 3167, 3202, 3211, 3252, 3283, 3302, 3335, 3346, 3380, 3404, 3415, 3425, 3443, 3483, 3635, 3657, 3673, 3710, 3758, 3811, 3826, 3828, 3855, 3892, 3967, 3991, 3999, 4012, 4019, 4024, 4068, 4073, 4098, 4107, 4110, 4115, 4135, 4141, 4144, 4175, 4239, 4260, 4383, 4544, 4790, 4797, 4823, 4872, 4957, 5036, 5086, 5130, 5152, 5241, 5273, 5466, 5511], 'recognition': [1131], 'pathogen': [1133], 'DNA': [1134, 1142, 1343, 1400, 1408, 1610, 3498, 3850, 4104, 4767, 5512], 'context': [1137], 'infection': [1139], 'cellular': [1141, 1177, 1244, 1338, 1480, 1730, 4866, 5156], 'that': [1143, 1288, 1465, 1489, 1528, 1554, 1624, 1690, 1705, 1760, 1863, 1886, 1970, 2012, 2029, 2294, 2304, 2344, 2400, 2692, 2779, 2796, 2803, 2843, 2883, 3010, 3051, 3067, 3080, 3155, 3161, 3314, 3341, 3626, 3640, 3654, 3698, 3715, 3734, 3746, 3780, 3785, 3837, 3845, 3864, 3913, 3924, 3937, 4008, 4124, 4187, 4229, 4267, 4673], 'is': [1144, 1306, 1348, 1394, 1424, 1534, 1550, 1611, 1662, 1675, 1710, 1854, 2042, 2296, 2775, 3013, 3024, 3072, 3087, 3099, 3157, 3185, 3233, 3697, 3700, 3741, 3751, 3761, 3773, 3809, 3815, 3843, 3882, 3901, 3943, 4015, 4036, 4179, 4227, 4912], 'released': [1145, 1344, 1360, 1409, 3853, 4016], 'damaged': [1147, 1346, 1362, 1411], 'cells.': [1148, 2099], 'Pro-inflammatory': [1149], 'TLR9': [1150, 1170, 1190, 1215, 1218, 1268, 1313, 1319, 1393, 1417, 1423, 1456, 1477, 1492, 1541, 1556, 1577, 1623, 1648, 1668, 1673, 1697, 1708, 1717, 1732, 1745, 1754, 1763, 1783, 1794, 1897, 1913, 1938, 1959, 1974, 1983, 1991, 2011, 2057, 2075, 2102, 2127, 2139, 2204, 2332, 2345, 2353, 2375, 2410, 2807, 2820, 2844, 3016, 3031, 3084, 3165, 3169, 3187, 3295, 3349, 3491, 3641, 3655, 3708, 3717, 3732, 3750, 3800, 3872, 3919, 3950, 3976, 3986, 4067, 4097, 4117, 4132, 4137, 4163, 4173, 4194, 4258, 4284, 4306, 4378, 4864], 'signalling': [1151, 1216, 1269, 1314, 1464, 1581, 1589, 1669, 1674, 1709, 1718, 2053, 2411, 3166, 3350, 3492, 3656, 3709, 3718, 3733, 3873, 4195, 4259, 4307], 'pathways': [1152, 4308], 'immune': [1154, 1258, 1375, 1419, 1427, 3525, 4739], 'have': [1156, 1162, 1471, 1687, 3935, 4292, 4675], 'been': [1157, 1272, 3778], 'well': [1158], 'investigated,': [1159], 'but': [1160, 1797, 1901, 2023, 2328, 3206, 3722, 4076], 'we': [1161, 1198, 1470, 1686, 1985, 2198, 2249, 2342, 2377, 2817, 2841, 2864, 2925, 3019, 3036, 3153, 3292, 3312, 3590, 3624, 3652, 3744, 3797, 3911, 4090, 4122, 4251, 4263], 'recently': [1163, 1271, 1688], 'discovered': [1164], 'an': [1165, 1378, 1473, 1663, 1892, 1978, 2239, 2776, 2799, 3088, 3465, 3762, 4145, 4829, 5043], 'alternative': [1166, 1214, 1312, 1474, 1667, 1707, 2048, 2374, 2409, 3030, 3083, 3164, 3348, 3707, 3716, 3731, 3871, 3975, 4193, 4257, 4283], 'pathway': [1167], 'which': [1169, 1189, 1231, 1647, 2230, 3428, 3677, 3808, 4116, 4178], 'temporarily': [1171], 'reduces': [1172, 1192, 1220, 1495, 1652, 2354, 3170, 3188], 'energy': [1173, 1193, 1283, 1496, 1631, 1694, 2510, 2870, 3505, 3660, 3736, 4870, 5320], 'substrates': [1174, 1194, 1497, 1632], 'induce': [1176, 1479, 2689, 3102, 4207], 'protection': [1178, 1481, 4867], 'cardiomyocytes': [1182, 1276, 1439, 1483, 1500, 1520, 1605, 1702, 1743, 1862, 1961, 1997, 2055, 2079, 2113, 2135, 2209, 2284, 2321, 2364, 2425, 2477, 2521, 2540, 2563, 2625, 2711, 2835, 3063, 3336, 3382, 3445, 3636, 3658, 3827, 3838, 3898, 3953, 4069, 4136, 4261, 4824, 4873], 'neurons.': [1184, 4875], 'However,': [1185, 1642, 1685, 3106], 'mechanism': [1187, 1645, 4254], 'stimulation': [1191, 1219, 1814, 2420, 2814, 2821, 3482, 4029, 4086, 4822], 'remained': [1195, 3118], 'unknown.': [1196, 1657], 'Here,': [1197], 'identify': [1199, 1724], 'calcium-transporting': [1201], 'ATPase,': [1202, 1828], '(also': [1204], 'known': [1205, 1671, 3100, 3779], 'as': [1206, 1208, 1823, 1835, 1878, 2268, 2576, 3045, 3079, 3107, 3471, 3832, 4196, 4303, 5368], 'Atp2a2),': [1207], 'molecule': [1211], 'pathway.': [1217, 1315], 'activity,': [1222, 3668], 'Ca2+': [1224, 1299, 1321, 1332, 1827, 2262, 2358, 2518, 2537, 2560, 2574, 2781, 2790, 2857, 2873, 2887, 2901, 2915, 2927, 2930, 2942, 2949, 2975, 2978, 2984, 2996, 3000, 3070, 3178, 3223, 3244, 3250, 3272, 3297, 3308, 3379, 3403, 3511, 3875, 4011, 4050, 5151, 5217, 5431, 5437], 'handling': [1225, 1322, 3071, 3179, 3273, 3298, 3512], 'between': [1226, 1301, 1323, 1519, 1937, 1990, 2806, 3229, 3255, 3274, 3299, 3582, 3952, 3985, 4493, 4901], 'SR/ER': [1228, 1302, 1325, 2517, 2536, 2559, 2860, 2890], 'mitochondria,': [1230, 3841], 'leads': [1232, 3684], 'decrease': [1235, 1329, 3140, 3644, 3672], 'levels': [1239, 1655, 3113, 3191, 3442, 3477, 3594, 3618, 3634, 5272, 5312, 5362], 'activation': [1242, 2394, 3683, 3825, 4033], 'protective': [1245, 1339, 1731, 4317], 'machinery.': [1246, 1340], 'These': [1247, 2288, 4005], 'findings': [1248], 'reveal': [1249], 'how': [1250, 3186], 'distinct': [1251, 1540, 3949, 4273, 4305], 'innate': [1252, 4958], 'can': [1254, 1413, 3642, 3927, 4541], 'be': [1255, 1445, 1977, 2254, 3260, 3269, 3852, 3928, 4542], 'elicited': [1256, 2626], 'cells—including': [1261], 'cardiomyocytes—using': [1262], 'same': [1264, 3077, 3830, 4209, 4269], 'ligand-receptor': [1265, 4270], 'system.': [1266], 'Synopsis': [1267], 'shown': [1273, 2007, 3414, 3936], 'protect': [1275, 1499], 'neurons': [1278, 1441, 1485, 1502, 3496], 'metabolism.': [1284], 'This': [1285, 4594], 'study': [1286, 3696], 'shows': [1287], 'it': [1289, 3776, 3842, 4226], 'does': [1290, 4129], 'so': [1291], 'inhibiting': [1293, 3093], 'activity': [1295, 2356, 2423, 2469, 2801, 2830, 2850, 3012, 3143, 3721], 'thus': [1297], 'transfer': [1300, 2511, 2871, 5218], 'mitochondria.': [1304, 1327, 5220], 'adaptor': [1309, 1664, 1681, 1725, 2045, 3160], 'modulates': [1320, 3296, 3659], 'A': [1328, 4529], 'subsequent': [1334, 1524], 'activates': [1337, 1639, 3739], 'Introduction': [1341], 'Extracellular': [1342], 'tissue': [1347, 1467, 3502, 3859, 4277], 'sign': [1350], 'danger.': [1352, 4742], 'In': [1353, 2246, 3326, 4063, 4088, 4248], 'danger': [1355], 'model': [1356, 4266], '12,': [1357, 2876], 'self-molecules': [1359], '(the': [1364], 'damage-associated': [1365], 'molecular': [1366, 1582, 1644, 1882, 5173], 'patterns': [1367], '(DAMP))': [1368], 'are': [1369, 1919, 2171, 2175, 2231, 2740, 3215, 3413, 3554, 4233, 4309, 4559], 'sensed': [1370], 'DAMP': [1372, 1389], 'receptors': [1373, 1382, 4789, 4938, 4956], 'on': [1374, 2982, 3028, 3680, 4592, 4961], 'cells,': [1376, 3994, 4114], 'triggering': [1377], 'inflammatory': [1379, 1463, 1512, 1588, 1672, 3529, 3972, 4162, 4328, 4832], 'response.': [1380, 3530, 4833], '(TLRs)': [1383], 'form': [1384], 'major': [1386, 2232], 'group': [1387, 4158], 'receptors.': [1390, 4963], 'Among': [1391], 'TLRs,': [1392], 'only': [1396, 2306, 3197, 4072], 'detecting': [1399, 2088], '(self': [1401], 'non-self)': [1403], '3,': [1404], 'hence,': [1406], 'trigger': [1414], 'inflammation': [1415], 'via': [1416, 1616, 3180, 3370, 3665], '2.': [1421, 2040], 'Naturally,': [1422], 'expressed': [1425, 2111, 3903], 'cells;': [1428], 'however,': [1429], 'its': [1430, 1954, 2195, 3771], 'expression': [1431, 1517, 1530, 1598, 2697, 3112, 3939, 4171, 4244], 'was': [1432, 1737, 1810, 1859, 1894, 1941, 2013, 2017, 2032, 2065, 2076, 2110, 2470, 2590, 2657, 2693, 2704, 2810, 2953, 3144, 3351, 4070, 4077, 4105, 4119, 4344, 4353, 4365, 4459, 4497, 4535, 4596], 'also': [1433, 1460, 2290, 2329, 3207, 3822, 3868, 4185, 4190, 4215, 4576], 'reported': [1434, 1472], '45.': [1442], 'It': [1443], 'would': [1444, 3851], 'very': [1446], 'damaging': [1447], 'such': [1449, 2267, 3997], 'organs': [1450], 'with': [1451, 1584, 1765, 1793, 1867, 1874, 1999, 2015, 2058, 2063, 2104, 2116, 2129, 2138, 2238, 2312, 2315, 2334, 2347, 2472, 2478, 2523, 2565, 2713, 2731, 2836, 2932, 3408, 3549, 3918, 4150, 4181, 4237, 4242, 4322, 4355, 4374, 4408, 4424, 4448, 4461, 4468, 4477, 5042, 5317], 'poor': [1452], 'regenerative': [1453], 'capacity,': [1454], 'if': [1455], 'operates': [1461, 1699], 'increases': [1466, 1634], 'damage.': [1468, 3860], 'Recently,': [1469], 'function': [1475], '6.': [1486, 1641, 3149, 3690, 3835, 3874, 3981, 4087, 4211], 'We': [1487, 3049, 3861, 3934, 4184, 4549, 4558], 'found': [1488, 2222, 2842, 3313, 3625, 3912, 4071, 4106, 4543], 'CpG-oligodeoxynucleotide': [1490], '(CpG-ODN;': [1491], 'ligand)': [1493], 'temporally': [1494], 'activating': [1504], 'AMP-activated': [1505, 2433], 'protein': [1506, 1553, 1778, 1822, 1838, 1910, 2310, 2434, 4905, 5010], 'kinase': [1507, 2435], '(AMPK)': [1508, 2436], 'without': [1509, 2480, 2672, 2838, 2934, 3330], 'inducing': [1510], 'canonical': [1511, 4327], 'signalling.': [1513, 3032, 3085], 'Comparison': [1514], 'profiles': [1518], 'macrophages': [1522, 1591], 'functional': [1525, 2044, 2368, 5176], 'studies': [1526, 2302], 'identified': [1527, 1820], 'level': [1531, 2698, 3220, 3598, 3940, 4245], 'Unc93b1': [1533, 1549, 1600, 3942, 3961, 4170, 4335], 'pivotal': [1536, 2405, 3945], 'switch': [1537, 3027, 3946, 5365], 'regulating': [1544], 'subcellular': [1545], 'localization': [1546, 3424], 'TLR9.': [1548, 2038], 'chaperon-like': [1552], 'helps': [1555], 'travel': [1557], 'ER': [1560, 1615, 1651, 2690, 3103, 3727, 3768, 3881, 4109, 4143, 4222, 4903, 5128], 'endosome': [1562, 4082], 'become': [1564], 'N-terminally': [1566], 'shed,': [1567], 'immune-prone': [1568], 'type': [1569], 'receptor.': [1571], 'After': [1572, 4439], 'ligand': [1573, 2813, 3801, 3819, 4189], 'stimulation,': [1574, 2845], 'cleaved': [1576, 4096], 'subsequently': [1578, 1629, 3678, 4148], 'forms': [1579], 'complex': [1583, 4165], 'MyD88': [1585, 1683, 4332], 'initiate': [1587, 3527], '78.': [1592], 'On': [1593], 'contrary,': [1595], 'under': [1596], 'low': [1597, 4243], 'differentiated': [1607, 3865], 'neurons,': [1608], 'endocytosed': [1609], 'transported': [1612, 4079, 4103], 'retrograde': [1618, 4125], 'route': [1619], 'bind': [1621], 'stays': [1625], 'at': [1626, 1719, 1771, 2106, 2145, 2349, 2550, 2627, 2956, 3120, 3595, 4311, 4413, 4434, 4454, 4483], 'ER,': [1628, 3136, 4075], 'decreases': [1630, 2421, 3362, 3735, 4825], 'AMP/ATP': [1636], 'ratio,': [1637], 'then': [1638, 4037, 4475], 'AMPK': [1640, 2396, 2445, 3060, 3522, 3740, 3824, 4198], 'intracellular': [1653, 4231, 5171], 'remains': [1656], 'Results': [1658], 'Discussion': [1660], 'mediated': [1676, 3352], 'common': [1679], 'TLR': [1680, 4915], 'molecule,': [1682], '9.': [1684], 'demonstrated': [1689, 1953, 2303, 2882, 3108, 3863], 'modulation': [1692, 3068, 3343], 'metabolism': [1695, 3506, 3661, 4871], 'still': [1698], 'MyD88−/−': [1701], '6,': [1703, 3743], 'suggesting': [1704, 2399, 3066, 3130, 3340, 3923], 'MyD88-independent': [1711], 'branches': [1713], 'pro-inflammatory': [1716], 'level.': [1722], 'To': [1723, 2365, 3033], 'molecules': [1726], 'alternative,': [1729], 'signalling,': [1733, 2376, 3977, 4285, 4329], 'tandem': [1734, 1847], 'affinity': [1735, 1848, 1857, 4368, 5432], 'purification': [1736, 1849, 1858, 4369], 'performed': [1738, 1860, 2378, 4634], 'primary': [1740], 'rat': [1741, 2207, 2588, 2710, 2938, 3426], 'neonatal': [1742, 1996, 2072, 2134, 2208, 2476, 2539, 2834], '(alternative': [1744, 1753], 'signal;': [1746, 1755], 'on)': [1747], 'cardiac': [1749, 1800, 1904, 2211, 2919, 5101, 5131, 5242, 5275], 'fibroblasts': [1750, 1801, 1872, 4372], 'comparison': [1752, 1781, 4492], 'off)': [1756], 'using': [1757, 1861, 1994, 2937, 3305, 3599, 3906, 4988, 5012, 5277], 'adenoviral': [1758], 'vectors': [1759], 'encoded': [1761, 5046, 5323], 'full-length': [1762], 'tagged': [1764], 'human': [1767], 'influenza': [1768], 'hemagglutinin': [1769], '(HA)-FLAG': [1770], 'C-terminus': [1773], '(TLR9-HA-FLAG)': [1774], 'or': [1775, 1869, 2272, 2479, 2500, 2528, 2567, 2837, 2933, 3122, 3391, 3459, 3495, 4021, 4298, 4334, 4371, 4379], 'Yellow': [1776], 'fluorescent': [1777, 5047, 5280], '(YFP)-HA-FLAG.': [1779], 'immunoprecipitates': [1784, 1898, 2205, 2225, 2237, 2282], 'revealed': [1785], 'existence': [1787], '95-kDa': [1790, 1808, 1888], 'band': [1791, 1809, 1889], 'associated': [1792, 3917], 'cardiomyocytes,': [1796, 1900, 2022, 2027, 2266, 2589, 2863, 3427], 'not': [1798, 1902, 2024, 2278, 2305, 2688, 3724, 4078, 4092, 4130, 4206], '(Fig': [1802, 1815, 2322, 2336, 2397, 2815, 2851, 2896, 2962, 3002, 3064, 3322, 3619, 3637, 4279], '1A).': [1803], 'Importantly,': [1804], 'intensity': [1805], 'increased': [1811, 1907, 2670, 3059, 3687], 'after': [1812, 2061, 2148, 2541, 2593, 2894, 2959, 3125, 3243, 3383, 3446, 3480, 5091], 'CpG-ODN': [1813, 1906, 2149, 2484, 2529, 2533, 2620, 2685, 2714, 2839, 2884, 2935, 2970, 3320, 3331, 3392, 3454, 3629, 3834, 3966, 4128, 4140], '1B).': [1816], 'spectrometric': [1818], 'analysis': [1819, 2202, 3375, 3438, 4490], 'sarcoplasmic': [1824], 'reticulum': [1825, 5038, 5084, 5098], '(SR)': [1826], 'SERCA2.': [1829, 4151], 'Figure': [1830, 1928, 2039, 2184, 2414, 2749, 2755, 2761, 2767, 3356, 3563, 3569, 4683, 4689, 4695], '1.': [1831], 'Identification': [1832], 'binding': [1837, 1911, 1955, 2234, 2805], 'toll-like': [1840, 2049, 4773, 4937], 'Representative': [1844, 2553, 2606, 3406], 'image': [1845], 'visualized': [1850], 'silver': [1852], 'stain': [1853], 'presented.': [1855], 'Tandem': [1856, 4367], 'were': [1864, 1876, 2136, 2153, 2164, 2221, 2277, 2462, 2494, 2545, 2643, 2679, 4091, 4381, 4420, 4446, 4505, 4517], 'adenovirally': [1865], 'transfected': [1866, 1873, 4373], 'TLR9-HA-FLAG': [1868, 1875, 2109, 2309], 'YFP-HA-FLAG.': [1870], 'Cardiac': [1871], 'used': [1877, 2865, 3470, 3798], 'control.': [1880, 2733, 3474, 3551], 'MW:': [1881], 'weight': [1883], 'markers.': [1884], 'Note': [1885], 'marked': [1890], 'asterisk': [1893], 'observed': [1895, 3050], 'fibroblasts.': [1905, 2212], 'target': [1909], '(asterisk)': [1914], 'cardiomyocytes.': [1916, 2073, 2132, 2352, 2385, 2413, 2940, 3168, 3303, 3405, 3484, 3711, 4099], 'data': [1918, 2174, 2289, 2461, 2493, 2678, 2739, 3553, 3713, 4006, 4516], 'available': [1920, 2176, 2741, 3555], 'online': [1921, 2177, 2742, 3556], 'figure.': [1924, 2180, 2745, 3559], '[embr201337945-sup-0005-SourceData-Fig1.pdf]': [1930], 'Download': [1931, 1933, 2187, 2189, 2770, 2772, 3572, 3574], 'figure': [1932, 2188, 2771, 3573], 'PowerPoint': [1934, 2190, 2773, 3575], 'association': [1936, 1975, 1989, 2031, 3926], 'verified': [1942], 'series': [1945], 'observations.': [1947], 'First,': [1948, 2826, 3304], 'reciprocal': [1949], 'co-immunoprecipitation': [1950, 4983], 'overexpressed': [1958, 2101, 2240, 2308], '(Supplementary': [1962, 2242, 2285, 3337, 3920, 4002], 'Fig': [1963, 2009, 2243, 2286, 2326, 3110, 3338, 3921, 4003], 'S1A).': [1964], 'Second,': [1965], 'exclude': [1967], 'possibility': [1969], 'might': [1976, 4291], 'artefact': [1979], 'due': [1980], 'overexpression,': [1984], 'checked': [1986], 'endogenous': [1988, 2331], 'mouse': [1995, 2071], 'treated': [1998, 2522, 2564, 2712], 'cell-permeable': [2001], 'crosslinker,': [2002], 'dithiobis[succinimidylpropionate]': [2003], '(DSP)': [2004], '10.': [2005], 'As': [2006, 2900, 2964, 3729], '2A,': [2010], 'co-immunoprecipitated': [2014], 'clearly': [2018, 2066], 'detected': [2019, 2067, 2279], 'wild-type': [2021, 2069], 'TLR9−/−': [2026, 2081], 'confirming': [2028, 2083], 'unrelated': [2033], 'overexpression': [2036], 'Co-immunoprecipitated': [2056, 2074], 'antibody': [2060, 2118], 'cross-linking': [2062], 'DSP': [2064], '(WT)': [2070], 'abolished': [2077, 2391], 'mice,': [2082], 'specificity': [2085], 'antibody.': [2089, 2125], 'Each': [2090], 'lane': [2091], 'contains': [2092], 'proteins': [2093, 2217, 2220, 2235, 2264], 'immunoprecipitated': [2094, 4407, 4447], '5': [2096, 2501], '×': [2097, 4430], '106': [2098], 'colocalized': [2103, 2128, 2311, 2333], 'ER/SR.': [2108, 2794], 'labelled': [2115], 'anti-HA': [2117, 4449], '(green)': [2119, 2140], 'addition': [2121], '(red)': [2124, 2143], 'Endogenous': [2126], 'Rat': [2133], 'stained': [2137], 'antibodies': [2144, 3909], '15': [2146, 4437], 'min': [2147, 2893, 2958], 'stimulation.': [2150, 2648, 2661, 3017], 'images': [2152, 2170, 2557, 3407], 'obtained': [2154, 2463, 2495, 2680], 'confocal': [2156], 'microscopy.': [2157], 'Scale': [2158, 2569, 3533], 'bar': [2159, 2570], 'indicates': [2160, 2571], '10': [2161, 2572, 2892, 3536, 4487], 'μm.': [2162, 2573, 3537], 'Experiments': [2163], 'repeated': [2165, 4522], 'three': [2166, 2465, 2682], 'times,': [2167], 'representative': [2169], 'shown.': [2172], '2': [2185, 5367], '[embr201337945-sup-0006-SourceData-Fig2.pdf]': [2186], 'Third,': [2191], 'further': [2193, 3578], 'confirm': [2194, 2366, 3579], 'specific': [2196], 'binding,': [2197], 'added': [2199], 'non-biased': [2200], 'proteomics': [2201], 'Most': [2213], 'heat': [2215], 'shock': [2216], 'ribosomal': [2219], 'both': [2227, 2644, 3915], 'cell': [2228, 3894, 3932, 3956, 4026, 5211], 'types,': [2229], 'non-specific': [2233], 'bait': [2241], 'S1B)': [2244], '11.': [2245], 'approach,': [2248], 'again': [2250], 'confirmed': [2251], 'cardiomyocyte-specific': [2256], 'TLR9-binding': [2257], 'protein,': [2258, 5282], 'while': [2259, 3524, 3757, 3995, 4200], 'other': [2260, 3931, 4025, 4230, 4299, 4503], 'abundant': [2261, 3840], 'pump': [2263], 'ryanodine': [2269], '(RyR)': [2271], 'inositol': [2273], '1,4,5-triphosphate': [2274], '(IP3R),': [2276], 'S1B).': [2287], 'support': [2291, 4563, 4581], 'our': [2292, 4064, 4182], 'finding': [2293, 3693], 'TLR9-associating': [2298], 'protein.': [2299], 'Finally,': [2300], 'immunofluorescence': [2301], 'ER/SR': [2317, 2350, 2362, 2787, 2907, 2983, 2995, 3230, 3256, 3276, 4014], 'marker': [2318], 'KDEL': [2319], '2B': [2323], 'Supplementary': [2325, 4546, 4682, 4688, 4694, 4700], 'S1C),': [2327], '2C).': [2337], 'Collectively': [2338, 3648], 'these': [2340, 3007, 3151, 3300, 3650], 'data,': [2341, 3651], 'conclude': [2343, 3154], 'interacts': [2346], 'content': [2359, 2928, 2943], 'involvement': [2369], 'knockdown': [2380, 2427, 3959], 'experiment': [2381], 'Different': [2386, 2438], 'siRNAs': [2387, 2439], 'targeting': [2388, 2440], 'efficiently': [2390], 'CpG-induced': [2393], '3A),': [2398], 'indeed': [2402, 3643], 'plays': [2403, 3279], '3.': [2415], 'RNAi-mediated': [2426], 'diminished': [2430], 'TLR9-induced': [2432, 2444], 'activation.': [2437, 2446, 4776], 'similarly': [2442], 'inhibited': [2443], 'Values': [2447], 'indicate': [2448, 2736, 3009, 3535, 3540], 'densitometric': [2449], 'ratio': [2450, 2514, 2549], 'pAMPK': [2452, 2671], 'tubulin': [2454], 'immunoblots,': [2456], 'mean': [2457], '±': [2458], 's.e.m.': [2459, 2737, 3541], 'independent': [2466, 2683], 'experiments.': [2467, 2684], 'Ca2+-ATPase': [2468, 2778, 2829], 'assessed': [2471, 2577, 2694, 4518], 'microsome': [2473], 'fractions': [2474], '30-min': [2481], 'treatment': [2482, 2595, 2936, 3056], 'over': [2485], 'two': [2486, 3489, 4495], 'different': [2487, 3490], 'concentrations': [2488], 'free': [2490], 'Ca2+.': [2491], '4': [2497], '(Ca2+;': [2498, 2502], '0.17)': [2499], '7.3)': [2503], 'preparations': [2504], 'each': [2506, 2918, 3411], 'group.': [2507], 'Förster': [2508, 2868], 'resonance': [2509, 2869, 5319], '(FRET)/CFP': [2512], 'emission': [2513], 'plots': [2515], 'probe': [2519, 2561], 'control': [2524, 2566, 2602, 2614, 3386, 3449, 4000], '(n': [2525, 2530, 2596, 2603, 3387, 3393, 3450, 3455, 3461], '=': [2526, 2531, 2597, 2604, 2617, 2623, 3388, 3394, 3451, 3456, 3462], '26)': [2527], '27).': [2532], 'significantly': [2534, 2591, 2847, 2885, 2954, 3316, 3400, 3478], 'reduced': [2535, 2848, 2886, 2955, 2971, 3014, 3401, 3630], 'CpG-ODN.': [2542, 2568, 2676], 'measurements': [2544], 'normalized': [2546], 'time': [2551, 2635, 2910, 2987], '0.': [2552], 'FRET/CFP': [2554], 'ratiometric': [2555], 'pseudocoloured': [2556], 'content,': [2575], 'amplitude': [2580, 2651, 2947, 2973], 'caffeine-induced': [2583, 2946], 'Fluo-4': [2584, 2610, 2641, 2654], 'transient': [2585, 2931, 2950, 2976, 3001, 3146, 3742], 'adult': [2587, 2939], 'decreased': [2592, 2658, 3333, 3584, 3666, 3719], 'CpG': [2594, 2647, 2660, 2960, 3398, 3481, 4085], '28)': [2598], 'compared': [2599, 2730, 3548], '26).': [2605], 'traces': [2607], 'cytosolic': [2609, 2914], 'transients': [2611, 2642, 2655], '(black;': [2615], 'n': [2616, 2622], '50)': [2618], '(red;': [2621], '51)-treated': [2624], '0.5': [2628], 'Hz': [2629], 'pacing.': [2630], 'Time': [2631], 'peak': [2633, 2989], '50%': [2637], 'decay': [2638, 2979], 'delayed': [2645], 'Also,': [2649], '(F/F0)': [2656], 'Thapsigargin': [2662, 3086], '(500': [2663], 'ng/ml': [2664], '0,': [2666], '15,': [2667, 3225], '30': [2668, 2957], 'min)': [2669], 'administration': [2674, 2686, 2895, 2961, 2968, 3127, 3321, 3329, 3399, 3627], 'did': [2687, 3723], 'GRP78': [2700, 3115], 'GRP94': [2702, 3117], 'measured': [2705, 2944, 3591], 'real-time': [2707], 'PCR': [2708], 'indicated': [2717], 'period.': [2718], 'information:': [2720, 3532], '*P': [2721], '<': [2722, 2725, 2728, 3543, 3546, 4533], '0.05': [2723, 4534], '**P': [2724, 3542], '0.01': [2726, 3544], '***P': [2727, 3545], '0.001': [2729, 3547], 'Error': [2734, 3538], 'bars': [2735, 3534, 3539], '3': [2750, 3123, 4429], '[embr201337945-sup-0007-SourceData-Fig3.pdf]': [2751], '3C': [2756, 2897], '[embr201337945-sup-0008-SourceData-Fig3C.xlsx]': [2757], '3E': [2762], '[embr201337945-sup-0009-SourceData-Fig3E.xlsx]': [2763], '3G': [2768], '[embr201337945-sup-0010-SourceData-Fig3G.xlsx]': [2769], 'ER/SR-resident': [2777], 'governs': [2780], 'uptake': [2782, 3876], 'cytosol': [2785, 3879], 'regulates': [2789], 'storage': [2791, 2902], 'Given': [2795, 3836], 'enzymatic': [2800], 'enhanced': [2811], '1B),': [2816], 'hypothesized': [2818], 'whether': [2819, 3021, 3294], 'could': [2822], 'modulate': [2823], 'activity.': [2825, 3195], 'measuring': [2828], 'treatment,': [2840], 'indeed,': [2846], '3B).': [2852], 'Next,': [2853, 3018, 3576], 'directly': [2855], 'monitor': [2856, 3431, 3614], 'living': [2862, 5315], 'SR/ER-targeting': [2867], '(FRET)-based': [2872], 'indicator,': [2874], 'D1ER': [2875], 'adenovirus-mediated': [2878], 'delivery.': [2879], 'Time-lapse': [2880, 3374, 3437, 4515], 'observation': [2881], 'D).': [2899], '(Ca2+': [2903, 2922], 'content)': [2904], 'controls': [2908], 'course': [2911], 'concentration': [2916, 3251], 'during': [2917], 'beating': [2920], 'cycle': [2921], 'transient),': [2923], 'next': [2924, 3183], 'analysed': [2926, 4646], 'SR': [2941], '(caffeine-induced': [2951], 'F/F0)': [2952], '3E).': [2963], 'consequence,': [2966], '(F/F0),': [2977], '(mostly': [2980], 'dependent': [2981, 4831], 're-uptake)': [2985], '(an': [2990], 'indication': [2991], 'speed': [2993], 'release)': [2997], '3F': [3003], 'G).': [3005], 'All': [3006], 'results': [3008], 'tested': [3020], 'sufficient': [3025, 3073], 'end,': [3035], 'exploited': [3037], 'property': [3039], 'low-molecular-weight': [3042], 'compound,': [3043], 'thapsigargin,': [3044], 'inhibitor.': [3048], 'short': [3052], 'periods': [3053], 'thapsigargin': [3055, 3096, 3328, 3760], 'alone': [3057], 'effectively': [3058, 3332], 'phosphorylation': [3061, 3213], '3H),': [3065], 'achieve': [3075], 'outcome': [3078], 'irreversible': [3089, 3763], 'inhibitor,': [3091], 'hours': [3098], '1314.': [3105], '3I,': [3111], 'unchanged': [3119], 'h': [3124], 'CpG-ODN,': [3129], 'no': [3131, 3996, 4676], 'substantial': [3132, 3846], 'damage': [3133], 'presumably': [3137], 'because': [3138], 'CpG-ODN-induced': [3139], 'incomplete,': [3145], 'reversible': [3148, 3754], 'From': [3150], 'results,': [3152], 'functioning': [3159, 3703], 'mediates': [3162, 4865], 'alteration': [3175, 3508], 'ER/mitochondria': [3177], 'question': [3184], 'decreasing': [3193], 'Not': [3196], 'several': [3198], 'matrix': [3200, 3378, 4450, 4458], 'dehydrogenases': [3201], 'TCA': [3204], 'cycle,': [3205], 'almost': [3208], 'all': [3209], 'steps': [3210], 'oxidative': [3212, 5373], '(OXPHOS)': [3214], 'positively': [3216], 'regulated': [3217, 3883], '([Ca2+]m)': [3224], 'close': [3227], 'proximity': [3228], 'mitochondria': [3232, 3258, 3278, 4040], 'regulation': [3238, 3285, 5154, 5209], '[Ca2+]m': [3240, 3315, 3334, 3345, 3369, 3585, 3664, 4058], '16.': [3241], 'Immediately': [3242], 'release': [3245, 4051], 'ER/SR,': [3248], 'local': [3249, 4043], 'space': [3254], 'will': [3259, 4319], 'high': [3261, 5430], 'enough': [3262], 'calcium': [3266, 4045, 5271], 'uniporter': [3267], 'activated.': [3270], 'Therefore,': [3271], 'critical': [3281], '1718.': [3290], 'Hence,': [3291], 'examined': [3293], 'organelles': [3301], 'mitochondria-targeting': [3307, 3601], 'probe,': [3309, 3604], 'G-CaMP2-mt': [3310], '19,': [3311], 'dropped': [3317, 3479], 'following': [3318], '4A': [3323], 'B).': [3325], 'addition,': [3327, 4089], 'S2A),': [3339], 'inhibition.': [3355], '4.': [3357], 'altering': [3368, 3663], 'A,': [3372, 4758, 4844, 5072, 5348, 5480, 5492], 'B.': [3373], 'G-CaMP2-mt-transfected': [3381], 'vehicle': [3385, 3448], '25;': [3389], 'circle)': [3390], '20;': [3395], 'triangle)': [3396, 3458], 'administration.': [3397], 'pseudocolour': [3409], 'condition': [3412], '(A).': [3416], 'C.': [3417], 'Adenovirus-mediated': [3418, 3607], 'transfection': [3419], 'mit-ATeam': [3421, 3605, 3610], 'showed': [3422, 3714, 4186], 'enabled': [3429, 3611], 'levels.': [3435], 'D.': [3436], 'mit-ATeam-transfected': [3444], '13;': [3452], 'circle),': [3453], '11;': [3457, 3463], 'oligomycin': [3460], 'square),': [3464], 'inhibitor': [3466, 3765, 4403], 'synthase': [3469], 'positive': [3473, 5370], 'Mitochondrial': [3475], 'E.': [3485], 'Schematic': [3486], 'presentation': [3487], 'pathways.': [3493], 'Cardiomyocytes': [3494, 4370], 'sense': [3497], '(danger': [3499], 'signal)': [3500], 'upon': [3501, 3858, 4028, 4276], 'injury,': [3503], 'reduce': [3504], 'microdomain': [3510], 'consequently': [3516], 'increase': [3517], 'tolerance': [3520, 3689], 'activation,': [3523, 4199], '4B': [3564], '[embr201337945-sup-0011-SourceData-Fig4B.xlsx]': [3565], '4D': [3570], '[embr201337945-sup-0012-SourceData-Fig4D.xlsx]': [3571], 'link': [3581], 'synthesis,': [3589, 3676, 4290], 'single-cell': [3597], 'FRET-based': [3602], '2021.': [3606], 'delivery': [3608], 'us': [3612], '4C).': [3620], 'Using': [3621], 'biosensor,': [3623], '4D),': [3638], 'indicating': [3639], 'synthesis.': [3647], 'concluded': [3653], 'leading': [3669], 'switches': [3679], 'AMPK,': [3681], 'whose': [3682], 'adaptor/mediator': [3704], 'Our': [3712], 'cause': [3725], 'detectable': [3726], 'stress.': [3728], 'substrate': [3737], 'speculated': [3745], 'relatively': [3752], 'short,': [3753], 'partial,': [3756], 'contrast': [3759], 'causes': [3767], 'when': [3770], 'long-term.': [3774], 'Indeed,': [3775, 3982], 'number': [3782], 'drugs': [3784], 'reversibly': [3786], 'inhibit': [3787], 'respiration': [3789], 'improve': [3790], 'recovery': [3791], 'ischaemia-reperfusion': [3793], 'injury': [3794, 4278], '22.': [3795], 'While': [3796], 'synthetic': [3799, 3833], '(CpG-ODN)': [3802], 'throughout': [3803], 'study,': [3805], 'DNA,': [3807], 'rich': [3810], 'unmethylated': [3812], 'CpGs': [3813], 'therefore': [3816], 'potent': [3818], 'TLR9,': [3821], 'induced': [3823], 'manner': [3831], 'possess': [3839], 'likely': [3844, 4228], 'amount': [3847], 'extracellularly': [3854], 'heart': [3857, 5090, 5134], 'previously': [3862], 'neuronal': [3866], 'operate': [3869], 'ubiquitous/housekeeping': [3886], 'splicing': [3887], 'isoform': [3888], 'SERCA2,': [3890], 'SERCA2b,': [3891], 'most': [3893], 'types': [3895, 4027, 4048], 'except': [3896], 'where': [3899], 'SERCA2a': [3900, 4554], 'predominantly': [3902], '23.': [3904], 'By': [3905], 'isoform-specific': [3908], '24,': [3910], 'isoforms': [3916, 5462], 'S2B),': [3922], 'TLR9-SERCA2': [3925], 'applied': [3929], 'types.': [3933], 'macrophage-like': [3955], 'line': [3957], 'RAW264.7;': [3958], 'transformed': [3962], 'response': [3964, 4210], 'RAW264.7': [3968, 3993, 4113], 'vice': [3979], 'versa': [3980], 'interaction': [3984, 3998, 4900], 'became': [3989], 'evident': [3990], 'Unc93b1-knocked-down': [3992, 4112], 'S2C).': [4004], 'suggest': [4007], 'stored': [4010], 'RyR': [4018], 'myocytes': [4020, 5276], 'IP3R': [4023], 'and/or': [4030], 'constitutive': [4031, 5214], 'focal': [4032], '17,': [4034], 'transferred': [4038], 'uniporter.': [4046], 'Both': [4047], 'contribute': [4052], 'maintenance': [4055], 'average': [4057], 'hence': [4060], 'bioenergetics.': [4062], 'previous': [4065], 'report,': [4066, 4250], 'regardless': [4083], 'able': [4093], 'detect': [4095], 'Further,': [4100], 'retrogradely': [4102], 'cleavage': [4118, 4133, 4174], 'inhibited.': [4120], 'Thus,': [4121], 'believe': [4123], 'transport': [4126, 4218], 'require': [4131], 'binds': [4138], 'uncleaved': [4146], 'form,': [4147], 'interacting': [4149, 4236], 'According': [4152], 'work': [4155, 4320], "Miyake's": [4157], '25,': [4159], 'bona-fide': [4161], '(TLR9N': [4166], '+': [4167, 5040, 5239], 'TLR9C)': [4168], 'requires': [4169], 'endosome,': [4177], 'consistent': [4180], 'model.': [4183], 'TLR7': [4188, 4214], 'triggers': [4191], 'TLR2': [4201], 'four': [4203], 'ligands': [4204], 'do': [4205], 'TLR3': [4212], 'use': [4216], 'Unc93b1-dependent': [4217], 'system': [4219, 4271, 4740], 'endosome;': [4224], 'therefore,': [4225], 'TLRs': [4232], 'capable': [4234], 'Ubc93b1.': [4247], 'uncovered': [4252], 'proposed': [4264], 'induces': [4272], 'biological': [4274], '4E).': [4280], 'Mimicking': [4281], 'therapeutic': [4293], 'potential': [4294, 4795], 'against': [4295], 'myocardial': [4296], 'infarction': [4297], 'sterile': [4300], 'inflammation.': [4301], 'Notably,': [4302], 'separated': [4310], 'level,': [4314], 'enhancing': [4315], 'effect': [4318], 'synergistically': [4321], 'unnecessary': [4326], 'example': [4331], 'knockdown.': [4336], 'Materials': [4337], 'Methods': [4339, 4701], 'Plasmids': [4340], 'Mouse': [4341], 'TLR9-myc': [4342], 'cDNA': [4343], 'kind': [4346], 'gift': [4347], 'Dr': [4349], 'Brinkmann.': [4350], 'C-terminal': [4351], 'myc': [4352], 'replaced': [4354], 'HA-FLAG': [4356], 'tag': [4357], 'PCR-based': [4360], 'method,': [4361], 'sequence': [4364], 'confirmed.': [4366], 'adenovirus': [4375], 'expressing': [4376], 'HA-FLAG-tagged': [4377], 'YFP': [4380], 'lysed': [4382], 'lysis': [4384, 4462], 'buffer': [4385, 4425, 4463, 4469], '(20': [4386], 'mM': [4387, 4400], 'MOPS,': [4388], 'pH': [4389], '7.4,': [4390], '10%': [4391], 'glycerol,': [4392], '0.15': [4393], 'M': [4394, 4472, 4479, 5265], 'NaCl,': [4395], '0.5%': [4396], '3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate': [4397], '(CHAPS),': [4398], 'EDTA,': [4401], 'protease': [4402], 'cocktail': [4404], '(Sigma))': [4405], 'anti-FLAG': [4409], 'M2': [4410], 'agarose': [4411], '(Sigma)': [4412, 4433], '4°C': [4414, 4435, 4455], 'h.': [4417], 'beads': [4419], 'washed': [4421, 4460], 'eluted': [4423, 4476], 'containing': [4426, 4470], '0.25': [4427], 'mg/ml': [4428], 'FLAG': [4431], 'peptide': [4432], 'min.': [4438, 4488], 'removal': [4440], 'FLAG-agarose,': [4443], 'eluates': [4445], '(Roche,': [4451], 'clone': [4452], '12CA5)': [4453], 'overnight.': [4456], 'HA': [4457], 'followed': [4464, 4509, 4524], 'another': [4466], 'wash': [4467], 'NaCl': [4473], '0.1': [4478], 'glycine-HCl': [4480], '(pH': [4481], '2.4)': [4482], 'room': [4484], 'temperature': [4485], 'Statistical': [4489], 'groups': [4496], 'made': [4498, 4506], 't-test': [4500], '(two-tailed),': [4501], 'comparisons': [4504], 'ANOVA': [4508, 4521], "Bonferroni's": [4511, 4526], 'post': [4512, 4527], 'hoc': [4513], 'test.': [4514], 'two-way': [4520], 'measure': [4523], 'hoc.': [4528], 'value': [4530], 'considered': [4536], 'statistically': [4537], 'significant.': [4538], 'Additional': [4539], 'methods': [4540], 'Methods.': [4547], 'Acknowledgements': [4548], 'thank': [4550, 4577], 'F.': [4551], 'Wuytack': [4552, 5421, 5451], 'b': [4556], 'antibodies.': [4557], 'grateful': [4560], 'project': [4566], 'members': [4569, 4587], 'laboratory.': [4573], 'authors': [4575, 4671], 'technical': [4580], 'Keiko': [4583], 'Shingu': [4584], 'Lab': [4591], 'revision.': [4593], 'research': [4595], 'supported': [4597], 'New': [4600], 'Investigator': [4601], 'Grant': [4603], 'Council': [4607], '(G1000461': [4608], 'Y.S.),': [4610], 'Charity': [4615], 'NIHR-Cardiovascular': [4617], 'Biomedical': [4618], 'Unit': [4620], '(to': [4621], 'K.S.).': [4622], 'contributions': [4624], 'YS': [4625, 4661], 'conceived': [4626], 'designed': [4628], 'research;': [4629, 4635], 'YS,': [4630, 4636], 'HCAD': [4631], 'HK': [4633], 'HCAD,': [4637], 'CMNT,': [4638, 4649], 'SRC,': [4639], 'HI,': [4640, 4651], 'AWP,': [4641], 'ST,': [4642, 4650], 'KY': [4643], 'KS': [4645, 4663], 'data;': [4647], 'HK,': [4648], 'MA,': [4652], 'JN,': [4653], 'HS,': [4654], 'HN': [4655], 'AWP': [4657], 'contributed': [4658], 'reagents/analytic': [4659], 'tools;': [4660], 'wrote': [4664], 'paper.': [4666], 'Conflict': [4667], 'interest': [4669], 'declare': [4672], 'they': [4674], 'conflict': [4677], 'interest.': [4679], 'Supporting': [4680], 'S1': [4684], '(application/PDF,': [4685, 4691, 4697, 4702, 4708], '602.8': [4686], 'KB)': [4687, 4693, 4699, 4704, 4710], 'S2': [4690], '376.1': [4692], 'S3': [4696], '371.4': [4698], '127.5': [4703], 'Review': [4705], 'Process': [4706], 'File': [4707], '872.5': [4709], 'References': [4711], 'Matzinger': [4712], '(1994)': [4714], 'Tolerance,': [4715], 'danger,': [4716], 'extended': [4719], 'family.': [4720], 'Annu': [4721], 'Rev': [4722, 4744, 5016, 5179], 'Immunol': [4723, 4745, 4799, 4965], '12:': [4724], '991–1045CrossrefCASPubMedWeb': [4725], 'Science®Google': [4727, 4749, 4781, 4807, 4839, 4884, 4923, 4945, 4969, 4997, 5023, 5057, 5108, 5141, 5162, 5183, 5225, 5248, 5290, 5333, 5383, 5406, 5447, 5475, 5519], 'Scholar': [4728, 4750, 4782, 4808, 4840, 4885, 4924, 4946, 4970, 4998, 5024, 5058, 5109, 5142, 5163, 5184, 5226, 5249, 5291, 5334, 5384, 5407, 5448, 5476, 5520], 'Kono': [4729], 'H,': [4730, 5198, 5293, 5297, 5336, 5338, 5346, 5416], 'Rock': [4731], 'KL': [4732], '(2008)': [4733, 4765, 4933], 'How': [4734], 'dying': [4735], 'alert': [4737], 'Nat': [4743, 4964, 5015, 5514], '8:': [4746, 5020], '279–289CrossrefCASPubMedWeb': [4747], 'Haas': [4751], 'T,': [4752, 4760, 4948, 5062, 5192, 5257, 5261, 5263, 5305, 5344, 5488], 'Metzger': [4753], 'J,': [4754, 5117, 5194, 5202, 5255, 5454], 'Schmitz': [4755], 'F,': [4756, 4850, 5422, 5452, 5490], 'Heit': [4757], 'Müller': [4759, 5195], 'Latz': [4761], 'E,': [4762, 4889, 5418], 'Wagner': [4763], 'H': [4764, 5307, 5496], 'sugar': [4768], 'backbone': [4769], '2′': [4770], 'deoxyribose': [4771], 'determines': [4772], 'Immunity': [4777], '28:': [4778], '315–323CrossrefCASPubMedWeb': [4779], 'Crack': [4783], 'PJ,': [4784], 'Bray': [4785], 'PJ': [4786], '(2007)': [4787, 4898, 4981, 5007], 'brain': [4792], 'their': [4794], 'roles': [4796], 'neuropathology.': [4798], 'Cell': [4800, 4918, 5018, 5221, 5401], 'Biol': [4801, 4919, 5019], '85:': [4802], '476–480Wiley': [4803], 'Online': [4804], 'LibraryCASPubMedWeb': [4805], 'Boyd': [4809], 'JH,': [4810], 'Mathur': [4811], 'S,': [4812, 4974, 5070, 5350, 5352, 5494], 'Wang': [4813, 5122], 'Y,': [4814, 4842, 5064, 5066, 5076, 5121, 5303, 5486], 'Bateman': [4815], 'RM,': [4816], 'Walley': [4817], 'KR': [4818], '(2006)': [4819, 5168], 'contractility': [4826], 'initiates': [4828], 'NF-kappaB': [4830], 'Cardiovasc': [4834], 'Res': [4835, 4992], '72:': [4836], '384–393CrossrefCASPubMedWeb': [4837], 'Kapoor': [4843], 'Kaneko': [4845], 'M,': [4846, 5002, 5074, 5196, 5228, 5251, 5253, 5259, 5340, 5411, 5414, 5478], 'Smolenski': [4847], 'RT,': [4848], "D'Acquisto": [4849], 'SR,': [4852], 'Harada-Shoji': [4853], 'N,': [4854, 4976], 'Lee': [4855], 'HJ,': [4856], 'Thiemermann': [4857], 'C,': [4858, 5028, 5113, 5186], 'S': [4860, 4950], 'et': [4861, 5079, 5205, 5355, 5497], 'al': [4862, 5080, 5206, 5356, 5498], '(2013)': [4863, 5499], 'Proc': [4876, 5049, 5325, 5375, 5439], 'Natl': [4877, 5050, 5326, 5376, 5440], 'Acad': [4878, 5051, 5327, 5377, 5441], 'Sci': [4879, 5052, 5328, 5378, 5442], 'USA': [4880, 5053, 5329, 5379, 5443], '110:': [4881, 5105], '5109–5114CrossrefCASPubMedWeb': [4882], 'Brinkmann': [4886, 4927], 'MM,': [4887, 4928], 'Spooner': [4888], 'Hoebe': [4890], 'K,': [4891, 5299], 'Beutler': [4892], 'B,': [4893, 5004, 5144], 'Ploegh': [4894, 4931], 'HL,': [4895], 'Kim': [4896, 4925], 'Y-M': [4897], 'membrane': [4904], 'UNC93B': [4906], 'TLR3,': [4908], '7,': [4909], 'crucial': [4913], 'signaling.': [4916], 'J': [4917, 5285, 5399, 5471], '177:': [4920], '265–275CrossrefCASPubMedWeb': [4921], 'Y-M,': [4926], 'Paquet': [4929], 'M-E,': [4930], 'HL': [4932], 'UNC93B1': [4934], 'delivers': [4935], 'nucleotide-sensing': [4936], 'endolysosomes.': [4940], 'Nature': [4941], '452:': [4942], '234–238CrossrefCASPubMedWeb': [4943], 'Kawai': [4947], 'Akira': [4949], '(2010)': [4951, 5207, 5231], 'pattern-recognition': [4955], 'immunity:': [4959], 'update': [4960], '11:': [4966], '373–384CrossrefCASPubMedWeb': [4967], 'Zhang': [4971], 'L,': [4972, 4978, 5111, 5420], 'Rayner': [4973], 'Katoku-Kikyo': [4975], 'Romanova': [4977], 'Kikyo': [4979], 'N': [4980], 'Successful': [4982], 'Oct4': [4985], 'Nanog': [4987], 'cross-linking.': [4989], 'Biochem': [4990, 5470], 'Biophys': [4991], 'Commun': [4993, 5515], '361:': [4994], '611–614CrossrefCASPubMedWeb': [4995], 'Gingras': [4999], 'A-C,': [5000], 'Gstaiger': [5001], 'Raught': [5003], 'Aebersold': [5005], 'Analysis': [5008], 'complexes': [5011], 'mass': [5013], 'spectrometry.': [5014], 'Mol': [5017, 5400], '645–654CrossrefCASPubMedWeb': [5021], 'Palmer': [5025], 'AE,': [5026], 'Jin': [5027], 'Reed': [5029], 'JC,': [5030], 'Tsien': [5031], 'RY': [5032], '(2004)': [5033, 5081], 'Bcl-2-mediated': [5034], 'alterations': [5035], 'endoplasmic': [5037, 5083, 5097], 'Ca2': [5039, 5238], 'analyzed': [5041], 'improved': [5044], 'genetically': [5045, 5322], 'sensor.': [5048], '101:': [5054], '17404–17409CrossrefCASPubMedWeb': [5055], 'Okada': [5059], 'K-I,': [5060], 'Minamino': [5061], 'Tsukamoto': [5063, 5067, 5341], 'Liao': [5065], 'O,': [5068, 5342], 'Hirata': [5071], 'Fujita': [5073], 'Nagamachi': [5075], 'Nakatani': [5077], 'T': [5078, 5167, 5354], 'Prolonged': [5082], 'hypertrophic': [5087], 'failing': [5089], 'aortic': [5092], 'constriction:': [5093], 'possible': [5094], 'contribution': [5095], 'myocyte': [5102], 'apoptosis.': [5103], 'Circulation': [5104, 5244], '705–712CrossrefPubMedWeb': [5106], 'Ni': [5110], 'Zhou': [5112], 'Duan': [5114], 'Q,': [5115], 'Lv': [5116], 'Fu': [5118], 'X,': [5119], 'Xia': [5120], 'DW': [5123], '(2011)': [5124, 5266], 'β-AR': [5125], 'blockers': [5126], 'suppresses': [5127], 'hypertrophy': [5132], 'failure.': [5135], 'PLoS': [5136], 'ONE': [5137], '6:': [5138], 'e27294CrossrefCASPubMedWeb': [5139], 'Glancy': [5143], 'Balaban': [5145], 'RS': [5146], '(2012)': [5147], 'Role': [5148], 'energetics.': [5157], 'Biochemistry': [5158], '51:': [5159], '2959–2973CrossrefCASPubMedWeb': [5160], 'Rizzuto': [5164], 'R,': [5165, 5301, 5484], 'Pozzan': [5166], 'Microdomains': [5169], 'Ca2+:': [5172], 'determinants': [5174], 'consequences.': [5177], 'Physiol': [5178], '86:': [5180], '369–408CrossrefCASPubMedWeb': [5181], 'Cárdenas': [5185], 'Miller': [5187], 'RA,': [5188], 'Smith': [5189], 'I,': [5190, 5409], 'Bui': [5191], 'Molgó': [5193], 'Vais': [5197], 'Cheung': [5199], 'K-H,': [5200], 'Yang': [5201], 'Parker': [5203], 'I': [5204], 'Essential': [5208], 'bioenergetics': [5212], 'InsP3': [5215], '142:': [5222], '270–283CrossrefCASPubMedWeb': [5223], 'Kohlhaas': [5227], 'Maack': [5229], 'C': [5230], 'Adverse': [5232], 'bioenergetic': [5233], 'consequences': [5234], 'Na+-Ca2+': [5236], 'exchanger-mediated': [5237], 'influx': [5240], 'myocytes.': [5243], '122:': [5245], '2273–2280CrossrefCASPubMedWeb': [5246], 'Iguchi': [5250], 'Kato': [5252, 5337], 'Takeda': [5256], 'Matsumoto-Ida': [5258], 'Kita': [5260], 'Kimura': [5262], 'Direct': [5267], 'monitoring': [5268], 'cultured': [5274], 'novel': [5279], 'indicator': [5281], 'GCaMP2-mt.': [5283], 'Int': [5284], 'Cardiol': [5286, 5402], '158:': [5287], '225–234CrossrefPubMedWeb': [5288], 'Nhat': [5294], 'KPH,': [5295], 'Togawa': [5296], 'Saito': [5298], 'Iino': [5300], 'Kato-Yamada': [5302], 'Nagai': [5304], 'Noji': [5306], '(2009)': [5308, 5391, 5425], 'Visualization': [5309], 'inside': [5313], 'single': [5314], 'fluorescence': [5318], 'transfer-based': [5321], 'indicators.': [5324], '106:': [5330, 5444], '15651–15656CrossrefCASPubMedWeb': [5331], 'Fujikawa': [5339], 'Nakano': [5347], 'Yamazaki': [5351], 'Matsuzaki': [5353], '(2014)': [5357], 'Evaluation': [5358], 'intramitochondrial': [5360], 'identifies': [5363], 'G0/G1': [5364], 'gene': [5366], 'regulator': [5371], 'phosphorylation.': [5374], '111:': [5380], '273–278CrossrefCASPubMedWeb': [5381], 'Burwell': [5385], 'LS,': [5386], 'Nadtochiy': [5387], 'SM,': [5388], 'Brookes': [5389], 'PS': [5390], 'Cardioprotection': [5392], 'metabolic': [5394], 'shut-down': [5395], 'gradual': [5397], 'wake-up.': [5398], '46:': [5403], '804–810CrossrefCASPubMedWeb': [5404], 'Vandecaetsbeek': [5408], 'Trekels': [5410], 'De': [5412], 'Maeyer': [5413], 'Ceulemans': [5415], 'Lescrinier': [5417], 'Raeymaekers': [5419], 'Vangheluwe': [5423], 'Structural': [5426], 'basis': [5427], 'ubiquitous': [5435], 'SERCA2b': [5436], 'pump.': [5438], '18533–18538CrossrefPubMedWeb': [5445], 'Eggermont': [5449], 'JA,': [5450], 'Verbist': [5453], 'Casteels': [5455], '(1990)': [5457], 'Expression': [5458], 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