Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2122515314', 'doi': 'https://doi.org/10.1093/oxfordjournals.jbchem.a124327', 'title': 'Interferon-γ Induces Different Subunit Organizations and Functional Diversity of Proteasomes1', 'display_name': 'Interferon-γ Induces Different Subunit Organizations and Functional Diversity of Proteasomes1', 'publication_year': 1994, 'publication_date': '1994-02-01', 'ids': {'openalex': 'https://openalex.org/W2122515314', 'doi': 'https://doi.org/10.1093/oxfordjournals.jbchem.a124327', 'mag': '2122515314', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8206875'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/oxfordjournals.jbchem.a124327', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184547178', 'display_name': 'The Journal of Biochemistry', 'issn_l': '0021-924X', 'issn': ['0021-924X', '1756-2651'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034938597', 'display_name': 'Masashi Aki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masashi Aki', 'raw_affiliation_strings': ['Department of Urology, School of Medicine, University of Tokushima.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, School of Medicine, University of Tokushima.', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015030223', 'display_name': 'Naoki Shimbara', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Naoki Shimbara', 'raw_affiliation_strings': ['Biomaterial Research Institute'], 'affiliations': [{'raw_affiliation_string': 'Biomaterial Research Institute', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079538023', 'display_name': 'Makoto Takashina', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Makoto Takashina', 'raw_affiliation_strings': ['Biomaterial Research Institute'], 'affiliations': [{'raw_affiliation_string': 'Biomaterial Research Institute', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014229743', 'display_name': 'Kinya Akiyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kinya Akiyama', 'raw_affiliation_strings': ['Department of Urology, School of Medicine The University of Tokushima'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, School of Medicine The University of Tokushima', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049100460', 'display_name': 'Shunsuke Kagawa', 'orcid': 'https://orcid.org/0000-0002-3610-8211'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Susumu Kagawa', 'raw_affiliation_strings': ['Department of Urology, School of Medicine The University of Tokushima'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, School of Medicine The University of Tokushima', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050855780', 'display_name': 'Tomohiro Tamura', 'orcid': 'https://orcid.org/0000-0003-2409-6556'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomohiro Tamura', 'raw_affiliation_strings': ['Institute for Enzyme Research, The University of Tokushima.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Enzyme Research, The University of Tokushima.', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078899794', 'display_name': 'Nobuyuki Tanahashi', 'orcid': 'https://orcid.org/0000-0003-1497-4685'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobuyuki Tanahashi', 'raw_affiliation_strings': ['Institute for Enzyme Research, The University of Tokushima.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Enzyme Research, The University of Tokushima.', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100922659', 'display_name': 'Tetsuro Yoshimura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuro Yoshimura', 'raw_affiliation_strings': ['Institute for Enzyme Research, The University of Tokushima.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Enzyme Research, The University of Tokushima.', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101573652', 'display_name': 'K Tanaka', 'orcid': 'https://orcid.org/0000-0002-1298-5375'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keiji Tanaka', 'raw_affiliation_strings': ['Institute for Enzyme Research, The University of Tokushima.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Enzyme Research, The University of Tokushima.', 'institution_ids': ['https://openalex.org/I922474255']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077387796', 'display_name': 'Akira Ichihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akira Ichihara', 'raw_affiliation_strings': ['Institute for Enzyme Research, The University of Tokushima.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Enzyme Research, The University of Tokushima.', 'institution_ids': ['https://openalex.org/I922474255']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.247, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 367, 'citation_normalized_percentile': {'value': 0.999966, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '115', 'issue': '2', 'first_page': '257', 'last_page': '269'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasmosis and Neosporosis Research', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gamma-subunit', 'display_name': 'Gamma subunit', 'score': 0.7350082}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.6747909}, {'id': 'https://openalex.org/keywords/proteasome', 'display_name': 'Proteasome', 'score': 0.560472}, {'id': 'https://openalex.org/keywords/antigen-processing', 'display_name': 'Antigen processing', 'score': 0.52084357}, {'id': 'https://openalex.org/keywords/proteasome-inhibitors', 'display_name': 'Proteasome Inhibitors', 'score': 0.508198}], 'concepts': [{'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.9430138}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.76559234}, {'id': 'https://openalex.org/C2910882050', 'wikidata': 'https://www.wikidata.org/wiki/Q5520320', 'display_name': 'Gamma subunit', 'level': 4, 'score': 0.7350082}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.6747909}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.54590255}, {'id': 'https://openalex.org/C108249834', 'wikidata': 'https://www.wikidata.org/wiki/Q3922363', 'display_name': 'Antigen processing', 'level': 5, 'score': 0.52084357}, {'id': 'https://openalex.org/C2780841837', 'wikidata': 'https://www.wikidata.org/wiki/Q24741149', 'display_name': 'Interferon gamma', 'level': 3, 'score': 0.5000515}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48801175}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.4762114}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.46873575}, {'id': 'https://openalex.org/C83464605', 'wikidata': 'https://www.wikidata.org/wiki/Q575296', 'display_name': 'Antigen presentation', 'level': 4, 'score': 0.46218976}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.45745528}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.42113772}, {'id': 'https://openalex.org/C170627219', 'wikidata': 'https://www.wikidata.org/wiki/Q13218497', 'display_name': 'MHC class I', 'level': 4, 'score': 0.4051959}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.36080417}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.33408198}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32854608}, {'id': 'https://openalex.org/C207936829', 'wikidata': 'https://www.wikidata.org/wiki/Q423163', 'display_name': 'Major histocompatibility complex', 'level': 3, 'score': 0.2662088}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.20228988}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18725166}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.12883681}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.07058108}], 'mesh': [{'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015395', 'descriptor_name': 'Histocompatibility Antigens Class I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007951', 'descriptor_name': 'Leukemia, Myeloid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008285', 'descriptor_name': 'Major Histocompatibility Complex', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008285', 'descriptor_name': 'Major Histocompatibility Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009693', 'descriptor_name': 'Nucleic Acid Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/oxfordjournals.jbchem.a124327', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184547178', 'display_name': 'The Journal of Biochemistry', 'issn_l': '0021-924X', 'issn': ['0021-924X', '1756-2651'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8206875', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 7, 'referenced_works': ['https://openalex.org/W1258228527', 'https://openalex.org/W1999506801', 'https://openalex.org/W2016355256', 'https://openalex.org/W2022092933', 'https://openalex.org/W2064993319', 'https://openalex.org/W2089482576', 'https://openalex.org/W5959882'], 'related_works': ['https://openalex.org/W4244317160', 'https://openalex.org/W2462657557', 'https://openalex.org/W2409344746', 'https://openalex.org/W2168513984', 'https://openalex.org/W2107554173', 'https://openalex.org/W2058264657', 'https://openalex.org/W2041638315', 'https://openalex.org/W2023967363', 'https://openalex.org/W1991142812', 'https://openalex.org/W1592776416'], 'abstract_inverted_index': {'To': [0], 'obtain': [1], 'information': [2], 'on': [3, 24, 158], 'the': [4, 9, 14, 25, 35, 38, 51, 65, 108, 117, 123, 128, 133, 147, 151, 163, 166], 'role': [5, 164], 'of': [6, 16, 30, 37, 72, 78, 89, 97, 110, 122, 150, 170, 178], 'proteasomes': [7, 171], 'in': [8, 69, 81, 107, 165, 182], 'immune': [10], 'system,': [11], 'we': [12, 161], 'examined': [13], 'effect': [15], 'a': [17], 'major': [18], 'immunomodulatory': [19], 'cytokine,': [20], 'gamma': [21], 'interferon': [22], '(IFN-gamma),': [23], 'expressions,': [26], 'structures,': [27], 'and': [28, 42, 56, 95, 119, 126], 'functions': [29], 'proteasomes.': [31, 112], 'IFN-gamma': [32, 84, 114, 143, 185], 'greatly': [33], 'increased': [34], 'levels': [36], 'mRNAs': [39], 'encoding': [40], 'LMP2': [41], 'LMP7,': [43], 'putative': [44], 'immuno-proteasome': [45], 'subunits': [46, 59, 92], 'encoded': [47], 'by': [48], 'genes': [49, 102], 'within': [50], 'class': [52], 'II': [53], 'MHC': [54], 'region,': [55], 'these': [57, 159], 'two': [58], 'synthesized': [60, 91], 'were': [61], 'assembled': [62], 'completely': [63], 'into': [64], 'proteasomal': [66], 'multi-subunit': [67], 'complex': [68], 'various': [70], 'types': [71], 'human': [73], 'cells.': [74], 'The': [75], 'subunit': [76, 180], 'organization': [77, 149], 'proteasome': [79, 101, 125], 'changed': [80], 'response': [82, 183], 'to': [83, 87, 184], 'stimulation,': [85], 'due': [86], 'assembly': [88, 181], 'newly': [90], 'through': [93, 176], 'up-': [94], 'down-expressions': [96], 'at': [98], 'least': [99], '6': [100], 'including': [103], 'LMP2/LMP7': [104], 'without': [105, 131], 'change': [106], 'structure': [109], 'pre-existing': [111], 'Interestingly,': [113], 'dramatically': [115], 'stimulated': [116], 'trypsin-like': [118], 'chymotrypsin-like': [120], 'activities': [121], 'multifunctional': [124], 'depressed': [127], 'peptidylglutamyl-peptide-hydrolyzing': [129], 'activity,': [130], 'affecting': [132], 'activity': [134], 'for': [135], 'ATP-,': [136], 'ubiquitin-dependent': [137], 'proteolysis.': [138], 'These': [139], 'results': [140], 'indicate': [141], 'that': [142], 'modifies': [144], 'not': [145], 'only': [146], 'structural': [148], 'proteasome,': [152], 'but': [153], 'also': [154], 'its': [155], 'functions.': [156], 'Based': [157], 'findings,': [160], 'discuss': [162], 'antigen': [167], 'processing/presentation': [168], 'pathway': [169], 'with': [172], 'functional': [173], 'diversity': [174], 'acquired': [175], 'alteration': [177], 'their': [179], 'stimulation.': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2122515314', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 25}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-09-08T22:53:49.754991', 'created_date': '2016-06-24'}