Title: Evaluation of Quantum Dot Cytotoxicity Based on Intracellular Uptake
Abstract: SmallVolume 2, Issue 12 p. 1412-1417 Communication Evaluation of Quantum Dot Cytotoxicity Based on Intracellular Uptake† Emmanuel Chang, Emmanuel Chang Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA, Fax: (+1) 713-348-5877Search for more papers by this authorNadhi Thekkek, Nadhi Thekkek Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA, Fax: (+1) 713-348-5877Search for more papers by this authorWilliam W. Yu Dr., William W. Yu Dr. Rice University, Department of Chemistry MS-60, PO Box 1892, Houston, TX 77251-1892, USASearch for more papers by this authorVicki L. Colvin Prof., Vicki L. Colvin Prof. Rice University, Department of Chemistry MS-60, PO Box 1892, Houston, TX 77251-1892, USASearch for more papers by this authorRebekah Drezek Prof., Rebekah Drezek Prof. [email protected] Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA, Fax: (+1) 713-348-5877Search for more papers by this author Emmanuel Chang, Emmanuel Chang Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA, Fax: (+1) 713-348-5877Search for more papers by this authorNadhi Thekkek, Nadhi Thekkek Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA, Fax: (+1) 713-348-5877Search for more papers by this authorWilliam W. Yu Dr., William W. Yu Dr. Rice University, Department of Chemistry MS-60, PO Box 1892, Houston, TX 77251-1892, USASearch for more papers by this authorVicki L. Colvin Prof., Vicki L. Colvin Prof. Rice University, Department of Chemistry MS-60, PO Box 1892, Houston, TX 77251-1892, USASearch for more papers by this authorRebekah Drezek Prof., Rebekah Drezek Prof. [email protected] Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA, Fax: (+1) 713-348-5877Search for more papers by this author First published: 27 October 2006 https://doi.org/10.1002/smll.200600218Citations: 313 † The authors would like to thank Diego Diaz and Christie Sayes for assistance with the use of the equipment. This work is supported in part by the Nanoscale Science and Engineering Initiative of the National Science Foundation under NSF Award Number EEC-0118007. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Nanoparticles, such as quantum dots (QDs), composed of biologically toxic materials degrade in highly oxidative environments. Varying the QD surface coating significantly affects the intracellular uptake of QDs. Although the addition of PEG does not alter the inherent QD cytotoxicity, we demonstrate that the improved biocompatibility due to PEG-substitution arises from decreased intracellular uptake, which allows for biological applications of QDs with minimal toxicity. The image shows the live/dead reagent stain used to quantitate cytotoxicity. PEG: poly(ethylene glycol). Citing Literature Volume2, Issue12December 2006Pages 1412-1417 RelatedInformation
Publication Year: 2006
Publication Date: 2006-10-09
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 366
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