Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2122372918', 'doi': 'https://doi.org/10.1093/jnci/djn254', 'title': 'Germline SDHB Mutations and Familial Renal Cell Carcinoma', 'display_name': 'Germline SDHB Mutations and Familial Renal Cell Carcinoma', 'publication_year': 2008, 'publication_date': '2008-08-26', 'ids': {'openalex': 'https://openalex.org/W2122372918', 'doi': 'https://doi.org/10.1093/jnci/djn254', 'mag': '2122372918', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18728283'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jnci/djn254', 'pdf_url': 'https://academic.oup.com/jnci/article-pdf/100/17/1260/7682415/djn254.pdf', 'source': {'id': 'https://openalex.org/S98010888', 'display_name': 'JNCI Journal of the National Cancer Institute', 'issn_l': '0027-8874', 'issn': ['0027-8874', '1460-2105'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jnci/article-pdf/100/17/1260/7682415/djn254.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089457536', 'display_name': 'Christopher J. Ricketts', 'orcid': 'https://orcid.org/0000-0003-4814-7207'}, 'institutions': [{'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'C. Ricketts', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I79619799', 'https://openalex.org/I4210150208', 'https://openalex.org/I2801316944']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036008455', 'display_name': 'Emma R. Woodward', 'orcid': 'https://orcid.org/0000-0002-6297-2855'}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'E. R. Woodward', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I2801316944', 'https://openalex.org/I79619799']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029313570', 'display_name': 'Pip Killick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'P. Killick', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I2801316944', 'https://openalex.org/I79619799']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026843001', 'display_name': 'Mark R. Morris', 'orcid': 'https://orcid.org/0000-0002-0700-355X'}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'M. R. Morris', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I2801316944', 'https://openalex.org/I79619799']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088627051', 'display_name': 'Dewi Astuti', 'orcid': 'https://orcid.org/0000-0003-4205-6160'}, 'institutions': [{'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'D. Astuti', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I2801316944', 'https://openalex.org/I79619799', 'https://openalex.org/I4210150208']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073770568', 'display_name': 'Farida Latif', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'F. Latif', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I2801316944', 'https://openalex.org/I79619799']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056034710', 'display_name': 'Eamonn R. Maher', 'orcid': 'https://orcid.org/0000-0002-6226-6918'}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I79619799', 'display_name': 'University of Birmingham', 'ror': 'https://ror.org/03angcq70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79619799']}, {'id': 'https://openalex.org/I4210099987', 'display_name': "Birmingham Women's Hospital", 'ror': 'https://ror.org/00xe5zs60', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099987', 'https://openalex.org/I4210155225']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'E. R. Maher', 'raw_affiliation_strings': ['Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)'], 'affiliations': [{'raw_affiliation_string': 'Affiliations of authors: Cancer Research UK Renal Molecular Oncology Group, Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Edgbaston, Birmingham, UK (CR, ERW, PK, MRM, DA, FL, ERM)', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I2801316944', 'https://openalex.org/I79619799']}, {'raw_affiliation_string': 'West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK (ERM)', 'institution_ids': ['https://openalex.org/I4210099987']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4978, 'currency': 'USD', 'value_usd': 4978, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 16.462, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 336, 'citation_normalized_percentile': {'value': 0.999963, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '100', 'issue': '17', 'first_page': '1260', 'last_page': '1262'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11054', 'display_name': 'Adrenal and Paraganglionic Tumors', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sdhb', 'display_name': 'SDHB', 'score': 0.9877149}, {'id': 'https://openalex.org/keywords/sdhd', 'display_name': 'SDHD', 'score': 0.9584526}, {'id': 'https://openalex.org/keywords/proband', 'display_name': 'Proband', 'score': 0.5009997}, {'id': 'https://openalex.org/keywords/folliculin', 'display_name': 'Folliculin', 'score': 0.4829042}], 'concepts': [{'id': 'https://openalex.org/C2780744430', 'wikidata': 'https://www.wikidata.org/wiki/Q14916125', 'display_name': 'SDHB', 'level': 5, 'score': 0.9877149}, {'id': 'https://openalex.org/C2776453936', 'wikidata': 'https://www.wikidata.org/wiki/Q14864964', 'display_name': 'SDHD', 'level': 5, 'score': 0.9584526}, {'id': 'https://openalex.org/C2776734335', 'wikidata': 'https://www.wikidata.org/wiki/Q581592', 'display_name': 'Paraganglioma', 'level': 2, 'score': 0.7791225}, {'id': 'https://openalex.org/C13514818', 'wikidata': 'https://www.wikidata.org/wiki/Q5552256', 'display_name': 'Germline mutation', 'level': 4, 'score': 0.74035406}, {'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.5663802}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5644415}, {'id': 'https://openalex.org/C2779512018', 'wikidata': 'https://www.wikidata.org/wiki/Q536269', 'display_name': 'Pheochromocytoma', 'level': 2, 'score': 0.50594896}, {'id': 'https://openalex.org/C188997412', 'wikidata': 'https://www.wikidata.org/wiki/Q1640386', 'display_name': 'Proband', 'level': 4, 'score': 0.5009997}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.49792194}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.48908716}, {'id': 'https://openalex.org/C97329493', 'wikidata': 'https://www.wikidata.org/wiki/Q18053203', 'display_name': 'Folliculin', 'level': 3, 'score': 0.4829042}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.44427162}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41511905}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38218898}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26453108}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2149969}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.20876026}], 'mesh': [{'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018095', 'descriptor_name': 'Germ-Line Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013385', 'descriptor_name': 'Succinate Dehydrogenase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000310', 'descriptor_name': 'Adrenal Gland Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000310', 'descriptor_name': 'Adrenal Gland Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010235', 'descriptor_name': 'Paraganglioma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010235', 'descriptor_name': 'Paraganglioma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010673', 'descriptor_name': 'Pheochromocytoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010673', 'descriptor_name': 'Pheochromocytoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013385', 'descriptor_name': 'Succinate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jnci/djn254', 'pdf_url': 'https://academic.oup.com/jnci/article-pdf/100/17/1260/7682415/djn254.pdf', 'source': {'id': 'https://openalex.org/S98010888', 'display_name': 'JNCI Journal of the National Cancer Institute', 'issn_l': '0027-8874', 'issn': ['0027-8874', '1460-2105'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18728283', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jnci/djn254', 'pdf_url': 'https://academic.oup.com/jnci/article-pdf/100/17/1260/7682415/djn254.pdf', 'source': {'id': 'https://openalex.org/S98010888', 'display_name': 'JNCI Journal of the National Cancer Institute', 'issn_l': '0027-8874', 'issn': ['0027-8874', '1460-2105'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.78}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1528834211', 'https://openalex.org/W181147267', 'https://openalex.org/W1967291345', 'https://openalex.org/W1976752846', 'https://openalex.org/W1977015709', 'https://openalex.org/W2019573100', 'https://openalex.org/W2021748258', 'https://openalex.org/W2025719835', 'https://openalex.org/W2043893634', 'https://openalex.org/W2057317080', 'https://openalex.org/W2068555261', 'https://openalex.org/W2080126243', 'https://openalex.org/W2094242056', 'https://openalex.org/W2101404359', 'https://openalex.org/W2108479829', 'https://openalex.org/W2116143852', 'https://openalex.org/W2119235043', 'https://openalex.org/W2120614573', 'https://openalex.org/W2126511952', 'https://openalex.org/W2130550277', 'https://openalex.org/W2132463881', 'https://openalex.org/W2144878030', 'https://openalex.org/W2151365359', 'https://openalex.org/W2152430532', 'https://openalex.org/W2152890695', 'https://openalex.org/W2156170457', 'https://openalex.org/W2168394145', 'https://openalex.org/W2804781330'], 'related_works': ['https://openalex.org/W3032011922', 'https://openalex.org/W2424926573', 'https://openalex.org/W2129273005', 'https://openalex.org/W2068005285', 'https://openalex.org/W2058502929', 'https://openalex.org/W2031213674', 'https://openalex.org/W2017691064', 'https://openalex.org/W1998986714', 'https://openalex.org/W1971547204', 'https://openalex.org/W1588499096'], 'abstract_inverted_index': {'Familial': [0], 'renal': [1], 'cell': [2], 'carcinoma': [3], '(RCC)': [4], 'is': [5, 10, 45], 'a': [6, 108, 114, 193], 'heterogeneous': [7], 'disorder': [8], 'that': [9, 163, 178], 'most': [11], 'commonly': [12], 'caused': [13], 'by': [14, 27], 'germline': [15, 50, 109, 115, 173], 'mutations': [16, 51, 88], 'in': [17, 52, 75, 89, 98, 149], 'the': [18, 39, 43, 103], 'VHL': [19], ',': [20, 22, 65, 67, 91, 93], 'MET': [21], 'and': [23, 131, 141, 190, 199], 'FLCN': [24], 'genes': [25, 62], 'or': [26, 58, 94, 125, 134, 139], 'constitutional': [28], 'chromosome': [29], '3': [30, 101], 'translocations.': [31], 'However,': [32], 'for': [33, 172, 188], 'many': [34], 'patients': [35, 77, 164], 'with': [36, 72, 78, 113, 119, 165], 'familial': [37, 120, 197], 'RCC,': [38, 189], 'genetic': [40], 'basis': [41], 'of': [42, 82, 102, 137, 147, 201], 'disease': [44], 'undefined.': [46], 'We': [47], 'investigated': [48], 'whether': [49], 'fumarate': [53], 'hydratase': [54], '(': [55, 63], 'FH': [56, 90], ')': [57, 69], 'succinate': [59], 'dehydrogenase': [60], 'subunit': [61], 'SDHB': [64, 110, 116, 150, 174, 181], 'SDHC': [66, 92], 'SDHD': [68, 95], 'were': [70, 96], 'associated': [71], 'RCC': [73, 84, 121, 127, 148, 168, 198], 'susceptibility': [74, 85], '68': [76, 104], 'no': [79, 132], 'clinical': [80], 'evidence': [81], 'an': [83], 'syndrome.': [86], 'No': [87], 'identified': [97, 180], 'probands,': [99], 'but': [100], '(4.4%)': [105], 'probands': [106], 'had': [107], 'mutation.': [111], 'Patients': [112], 'mutation': [117, 151, 182], 'presented': [118], '(n': [122, 128], '=': [123, 129], '1)': [124, 161], 'bilateral': [126], '2)': [130, 176], 'personal': [133], 'family': [135], 'history': [136], 'pheochromocytoma': [138], 'head': [140], 'neck': [142], 'paraganglioma.': [143], 'Age': [144], 'at': [145], 'diagnosis': [146], 'carriers': [152, 183], 'ranged': [153], 'from': [154], '24': [155], 'to': [156], '73': [157], 'years.': [158], 'These': [159], 'findings': [160], 'demonstrate': [162], 'suspected': [166], 'inherited': [167], 'should': [169, 184], 'be': [170, 185], 'examined': [171], 'mutations,': [175], 'suggest': [177], 'all': [179], 'offered': [186], 'surveillance': [187], '3)': [191], 'provide': [192], 'further': [194], 'link': [195], 'between': [196], 'activation': [200], 'hypoxic-gene': [202], 'response': [203], 'pathways.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2122372918', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 20}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 31}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 40}, {'year': 2013, 'cited_by_count': 36}, {'year': 2012, 'cited_by_count': 29}], 'updated_date': '2024-12-07T22:48:36.251097', 'created_date': '2016-06-24'}