Publication Information

{'id': 'https://openalex.org/W2122082432', 'doi': 'https://doi.org/10.1093/jac/dkq160', 'title': 'TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium', 'display_name': 'TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium', 'publication_year': 2010, 'publication_date': '2010-05-22', 'ids': {'openalex': 'https://openalex.org/W2122082432', 'doi': 'https://doi.org/10.1093/jac/dkq160', 'mag': '2122082432', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20495209'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkq160', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1093/jac/dkq160', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051599788', 'display_name': 'Tsukasa Horiyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tsukasa Horiyama', 'raw_affiliation_strings': ['Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan', 'Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052384578', 'display_name': 'Akihito Yamaguchi', 'orcid': 'https://orcid.org/0000-0001-8083-7609'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akihito Yamaguchi', 'raw_affiliation_strings': ['Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001173964', 'display_name': 'Kunihiko Nishino', 'orcid': 'https://orcid.org/0000-0003-3349-1769'}, 'institutions': [{'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}, {'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kunihiko Nishino', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan', 'Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'PRESTO, Japan Science and Technology Agency, 5-3 Yonbancho, Chiyodaku, Tokyo 102-8666, Japan'], 'affiliations': [{'raw_affiliation_string': 'PRESTO, Japan Science and Technology Agency, 5-3 Yonbancho, Chiyodaku, Tokyo 102-8666, Japan', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': 'Laboratory of Microbiology and Infectious Diseases, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2627, 'currency': 'GBP', 'value_usd': 3222, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.048, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 108, 'citation_normalized_percentile': {'value': 0.999442, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '65', 'issue': '7', 'first_page': '1372', 'last_page': '1376'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10943', 'display_name': 'Escherichia coli research studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10943', 'display_name': 'Escherichia coli research studies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10486', 'display_name': 'Salmonella and Campylobacter epidemiology', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1106', 'display_name': 'Food Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/salmonella-enterica', 'display_name': 'Salmonella enterica', 'score': 0.90078104}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.81579196}], 'concepts': [{'id': 'https://openalex.org/C2779607309', 'wikidata': 'https://www.wikidata.org/wiki/Q2264864', 'display_name': 'Salmonella enterica', 'level': 4, 'score': 0.90078104}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.81579196}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.7607305}, {'id': 'https://openalex.org/C2781065037', 'wikidata': 'https://www.wikidata.org/wiki/Q150839', 'display_name': 'Salmonella', 'level': 3, 'score': 0.71194595}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.6517173}, {'id': 'https://openalex.org/C10389963', 'wikidata': 'https://www.wikidata.org/wiki/Q848328', 'display_name': 'Serotype', 'level': 2, 'score': 0.64703476}, {'id': 'https://openalex.org/C2778910516', 'wikidata': 'https://www.wikidata.org/wiki/Q380136', 'display_name': 'Enterobacteriaceae', 'level': 4, 'score': 0.5335228}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41615072}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.36447734}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.24996236}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.24972606}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.22153732}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10536662}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06701252}], 'mesh': [{'descriptor_ui': 'D001425', 'descriptor_name': 'Bacterial Outer Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001425', 'descriptor_name': 'Bacterial Outer Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024901', 'descriptor_name': 'Drug Resistance, Multiple, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012486', 'descriptor_name': 'Salmonella typhimurium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012486', 'descriptor_name': 'Salmonella typhimurium', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001425', 'descriptor_name': 'Bacterial Outer Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012486', 'descriptor_name': 'Salmonella typhimurium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkq160', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20495209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkq160', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W1573080626', 'https://openalex.org/W1992144107', 'https://openalex.org/W1996452607', 'https://openalex.org/W2088095424', 'https://openalex.org/W2116137883', 'https://openalex.org/W2116201639', 'https://openalex.org/W2119311217', 'https://openalex.org/W2132067013', 'https://openalex.org/W2143095073', 'https://openalex.org/W2171706277'], 'related_works': ['https://openalex.org/W2899636055', 'https://openalex.org/W2802438013', 'https://openalex.org/W2419443326', 'https://openalex.org/W2410634484', 'https://openalex.org/W2112040638', 'https://openalex.org/W2087124265', 'https://openalex.org/W2058846600', 'https://openalex.org/W2019786050', 'https://openalex.org/W1974842464', 'https://openalex.org/W1853827125'], 'abstract_inverted_index': {'TolC': [0, 42, 63], 'is': [1, 152], 'a': [2, 17], 'major': [3], 'outer': [4], 'membrane': [5], 'channel': [6], 'and': [7, 90, 100, 168], 'it': [8], 'plays': [9], 'an': [10], 'important': [11], 'role': [12], 'in': [13, 52, 69, 170], 'the': [14, 41, 62, 74, 81, 102, 111, 126, 135, 149, 155], 'excretion': [15], 'of': [16, 20, 44, 56, 65, 93, 105, 157], 'wide': [18], 'range': [19], 'molecules,': [21], 'including': [22], 'antibiotics.': [23], 'A': [24], 'recent': [25], 'study': [26, 58], 'has': [27, 34], 'shown': [28], 'that': [29], 'Salmonella': [30], 'enterica': [31, 95, 172], 'serovar': [32, 96, 173], 'Typhimurium': [33, 97], 'nine': [35], 'functional': [36], 'drug': [37, 75, 103, 132, 159], 'efflux': [38, 46, 67, 76, 160], 'pumps;': [39], 'however,': [40], 'dependency': [43, 64], 'these': [45, 106], 'pumps': [47, 68], 'remains': [48], 'to': [49, 60, 125, 134, 148], 'be': [50], 'studied': [51], 'detail.': [53], 'The': [54], 'aim': [55], 'this': [57, 70], 'was': [59], 'investigate': [61], 'multidrug': [66], 'organism.All': [71], 'genes': [72, 120], 'encoding': [73], 'systems': [77, 161], 'were': [78, 86, 108], 'cloned': [79], 'into': [80, 88], 'pUC118': [82], 'vector.': [83], 'Constructed': [84], 'plasmids': [85, 140], 'transformed': [87], 'DeltaacrB': [89], 'DeltatolC': [91], 'mutants': [92], 'S.': [94, 171], 'ATCC': [98], '14028s,': [99], 'then': [101], 'susceptibilities': [104], 'transformants': [107], 'determined.Plasmids': [109], 'carrying': [110, 141], 'acrAB,': [112], 'acrD,': [113], 'acrEF,': [114], 'mdsAB,': [115], 'mdtABC,': [116], 'emrAB': [117], 'or': [118, 144], 'macAB': [119], 'did': [121], 'not': [122], 'confer': [123], 'resistance': [124, 133, 147], 'tolC': [127, 150], 'mutant,': [128], 'whereas': [129], 'they': [130], 'conferred': [131, 146], 'acrB': [136], 'mutant.': [137], 'Only': [138], 'three': [139], 'mdsABC,': [142], 'mdfA': [143], 'mdtK': [145], 'mutant.TolC': [151], 'required': [153], 'for': [154], 'function': [156], 'seven': [158], '(AcrAB,': [162], 'AcrD,': [163], 'AcrEF,': [164], 'MdsAB,': [165], 'MdtABC,': [166], 'EmrAB': [167], 'MacAB)': [169], 'Typhimurium.': [174]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2122082432', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-10T13:01:20.886971', 'created_date': '2016-06-24'}