Title: Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High‐Affinity Binding Sites in both Cross‐ and Self‐Association
Abstract: Angewandte Chemie International EditionVolume 49, Issue 17 p. 3081-3085 Communication Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association† Erika Andreetto, Erika Andreetto Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this authorLi-Mei Yan Dr., Li-Mei Yan Dr. Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this authorMarianna Tatarek-Nossol, Marianna Tatarek-Nossol Lehrstuhl für Biochemie und Molekulare Zellbiologie, RWTH Aachen, 52074 Aachen (Germany)Search for more papers by this authorAleksandra Velkova Dr., Aleksandra Velkova Dr. Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this authorRonald Frank Dr., Ronald Frank Dr. Abteilung Chemische Biologie, Helmholtz Zentrum für Infektionsforschung, 38106 Braunschweig (Germany)Search for more papers by this authorAphrodite Kapurniotu Prof. Dr., Aphrodite Kapurniotu Prof. Dr. [email protected] Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this author Erika Andreetto, Erika Andreetto Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this authorLi-Mei Yan Dr., Li-Mei Yan Dr. Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this authorMarianna Tatarek-Nossol, Marianna Tatarek-Nossol Lehrstuhl für Biochemie und Molekulare Zellbiologie, RWTH Aachen, 52074 Aachen (Germany)Search for more papers by this authorAleksandra Velkova Dr., Aleksandra Velkova Dr. Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this authorRonald Frank Dr., Ronald Frank Dr. Abteilung Chemische Biologie, Helmholtz Zentrum für Infektionsforschung, 38106 Braunschweig (Germany)Search for more papers by this authorAphrodite Kapurniotu Prof. Dr., Aphrodite Kapurniotu Prof. Dr. [email protected] Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan (Germany), Fax: (+49) 8161-713-298 http://www.wzw.tum.de/pbchSearch for more papers by this author First published: 01 April 2010 https://doi.org/10.1002/anie.200904902Citations: 147 † E. Andreetto and L.-M. Yan contributed equally to this work. This work has been supported by the Deutsche Forschungsgemeinschaft (DFG). We are grateful to S. Daenicke for synthesis of peptide arrays. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Short peptide sequences are identified as hot regions of the cross-interaction interface of the Alzheimer's disease β-amyloid peptide (Aβ) with the type 2 diabetes islet amyloid polypeptide (IAPP). They are shown to be high-affinity ligands of both Aβ and IAPP, thus suggesting common molecular recognition features in amyloid self- and cross-amyloid hetero-assembly. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_200904902_sm_miscellaneous_information.pdf420.6 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume49, Issue17April 12, 2010Pages 3081-3085 RelatedInformation
Publication Year: 2010
Publication Date: 2010-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 175
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