Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2121754251', 'doi': 'https://doi.org/10.1016/s0021-9258(17)30517-3', 'title': 'Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine', 'display_name': 'Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine', 'publication_year': 1990, 'publication_date': '1990-11-01', 'ids': {'openalex': 'https://openalex.org/W2121754251', 'doi': 'https://doi.org/10.1016/s0021-9258(17)30517-3', 'mag': '2121754251', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2173705'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)30517-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(17)30517-3', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052418709', 'display_name': 'J. Paul Secrist', 'orcid': 'https://orcid.org/0000-0003-0447-6295'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J P Secrist', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049098692', 'display_name': 'Inder Sehgal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'I Sehgal', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011101496', 'display_name': 'Garth Powis', 'orcid': 'https://orcid.org/0000-0003-3976-8415'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G Powis', 'raw_affiliation_strings': ['Experimental Therapeutics'], 'affiliations': [{'raw_affiliation_string': 'Experimental Therapeutics', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010517097', 'display_name': 'Robert T. Abraham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R T Abraham', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.755, 'has_fulltext': False, 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.757195, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '265', 'issue': '33', 'first_page': '20394', 'last_page': '20400'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.815033}], 'concepts': [{'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.815033}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5700462}, {'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.5591029}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.55555224}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50081396}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4715122}, {'id': 'https://openalex.org/C79186569', 'wikidata': 'https://www.wikidata.org/wiki/Q14897880', 'display_name': 'Tropomyosin receptor kinase C', 'level': 5, 'score': 0.41739}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4006287}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34977}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.30583763}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.27274203}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27263176}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.2537014}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)30517-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(17)30517-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1483755415', 'https://openalex.org/W1495653195', 'https://openalex.org/W1498793897', 'https://openalex.org/W1514031343', 'https://openalex.org/W1529423586', 'https://openalex.org/W1540941492', 'https://openalex.org/W1553151363', 'https://openalex.org/W1570617743', 'https://openalex.org/W1589866689', 'https://openalex.org/W1598006501', 'https://openalex.org/W1603483234', 'https://openalex.org/W1603499703', 'https://openalex.org/W1786972795', 'https://openalex.org/W1791835931', 'https://openalex.org/W1883414954', 'https://openalex.org/W1906860287', 'https://openalex.org/W1966969850', 'https://openalex.org/W1968446194', 'https://openalex.org/W1968610357', 'https://openalex.org/W1971722347', 'https://openalex.org/W1983596426', 'https://openalex.org/W1985527771', 'https://openalex.org/W1986694073', 'https://openalex.org/W1999145466', 'https://openalex.org/W2015223741', 'https://openalex.org/W2018698400', 'https://openalex.org/W2027592407', 'https://openalex.org/W2037434894', 'https://openalex.org/W2042381968', 'https://openalex.org/W2045956897', 'https://openalex.org/W2049057488', 'https://openalex.org/W2050338578', 'https://openalex.org/W2051531396', 'https://openalex.org/W2068669272', 'https://openalex.org/W2072105764', 'https://openalex.org/W2074571771', 'https://openalex.org/W2093602828', 'https://openalex.org/W2100837269', 'https://openalex.org/W2119941761', 'https://openalex.org/W2123904777', 'https://openalex.org/W2167622537', 'https://openalex.org/W2167963365', 'https://openalex.org/W2313488969', 'https://openalex.org/W287335106'], 'related_works': ['https://openalex.org/W2395338823', 'https://openalex.org/W2379511625', 'https://openalex.org/W2326027500', 'https://openalex.org/W2172112093', 'https://openalex.org/W2160930114', 'https://openalex.org/W2121754251', 'https://openalex.org/W2069637592', 'https://openalex.org/W2044148403', 'https://openalex.org/W2023447434', 'https://openalex.org/W1491141179'], 'abstract_inverted_index': {'Ligand': [0], 'stimulation': [1, 18, 134], 'of': [2, 13, 19, 45, 66, 122, 129, 135, 161, 204, 221], 'the': [3, 14, 87, 111, 119, 127, 167, 222], 'platelet-derived': [4], 'growth': [5, 175], 'factor': [6, 176], 'receptor': [7, 15, 102, 177], '(PDGF-R)': [8], 'results': [9], 'in': [10, 24, 53, 100, 105, 186], 'rapid': [11], 'activation': [12, 99, 145, 220], 'tyrosine': [16, 97, 120, 179, 224], 'kinase,': [17], 'phosphoinositide': [20, 208], 'hydrolysis,': [21], 'an': [22], 'increase': [23], 'intracellular': [25], 'free': [26], 'Ca2+': [27, 211], 'concentration': [28], '([Ca2+]i),': [29], 'and,': [30], 'ultimately,': [31], 'cellular': [32], 'proliferation.': [33], 'In': [34, 86, 138], 'a': [35, 42, 59, 214], 'previous': [36], 'study,': [37, 89], 'we': [38, 90], 'demonstrated': [39], 'that': [40, 61, 92, 173, 201], 'staurosporine,': [41], 'known': [43], 'inhibitor': [44], 'protein': [46, 67], 'kinase': [47, 68, 98, 180], 'C,': [48], 'blocked': [49], 'PDGF-induced': [50], '[Ca2+]i': [51], 'increases': [52], 'Swiss': [54, 107], 'mouse': [55], '3T3': [56, 108], 'fibroblasts': [57], 'by': [58, 132, 147, 166, 171], 'mechanism': [60], 'appeared': [62], 'unrelated': [63], 'to': [64, 155, 195], 'inhibition': [65], 'activity': [69, 125, 181], '(Olsen,': [70], 'R.,': [71, 77], 'Melder,': [72], 'D.,': [73], 'Seewald,': [74], 'M.,': [75], 'Abraham,': [76], 'and': [78, 104, 126, 182, 210], 'Powis,': [79], 'G.': [80], '(1990)': [81], 'Biochem.': [82], 'Pharmacol.': [83], '39,': [84], '968-972).': [85], 'present': [88], 'report': [91], 'staurosporine': [93, 116, 162, 205], 'inhibits': [94], 'ligand-dependent': [95], 'PDGF-R': [96, 168, 223], 'cell-free': [101], 'preparations': [103], 'intact': [106, 136], 'cells.': [109, 137], 'At': [110], 'same': [112], 'concentrations': [113, 203], '(10(-8)-10(-6)': [114], 'M),': [115], 'suppressed': [117], 'both': [118], 'phosphorylation': [121], 'phospholipase': [123, 143, 184], 'C': [124, 144, 185], 'hydrolysis': [128, 209], 'phosphoinositides': [130], 'induced': [131, 146], 'PDGF': [133], 'contrast,': [139], 'guanine': [140], 'nucleotide-binding': [141], 'protein-dependent': [142], 'bradykinin': [148], 'or': [149], 'fluoroaluminate': [150], 'anion': [151], 'was': [152, 169], 'relatively': [153], 'insensitive': [154], 'staurosporine.': [156], 'A': [157], 'preferential': [158], 'inhibitory': [159, 216], 'effect': [160, 217], 'on': [163, 218], 'signal': [164], 'generation': [165], 'indicated': [170], 'findings': [172], 'epidermal': [174], '(EGF-R)': [178], 'EGF-dependent': [183], 'A-431': [187], 'carcinoma': [188], 'cells': [189], 'were': [190], 'approximately': [191], '100-fold': [192], 'less': [193], 'sensitive': [194], 'this': [196], 'drug.': [197], 'These': [198], 'data': [199], 'indicate': [200], 'submicromolar': [202], 'inhibit': [206], 'PDGF-dependent': [207], 'mobilization': [212], 'through': [213], 'proximal': [215], 'ligand-induced': [219], 'kinase.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2121754251', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-24T13:20:01.678617', 'created_date': '2016-06-24'}