Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain

Name: Work Video:
Duration: 3 min 30 s
Philippe Lière; Antoine Pianos; Bernard Eychenne; Annie Cambourg; Suya Liu; William J. Griffiths; Michaël Schumacher; Jan Sjövall; Etienne‐Emile Baulieu
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'https://openalex.org/W2048547196', 'https://openalex.org/W2046714301', 'https://openalex.org/W2020787068', 'https://openalex.org/W1966065254', 'https://openalex.org/W1576839117'], 'abstract_inverted_index': {'A': [0, 191, 2804, 2828, 3516, 4080, 4190], 'new': [1, 192], 'sample': [2, 193, 2806, 3481], 'preparation': [3, 194], 'method': [4, 195, 1789, 3004], 'coupled': [5, 196], 'to': [6, 88, 197, 279, 427, 660, 1276, 1518, 1683, 1751, 1812, 2032, 2188, 2329, 2359, 2517, 2595, 2602, 3007, 3109, 3190, 3231, 3261, 3327, 3413, 3436, 3442, 3451, 3456, 3511, 3543, 3578, 3752, 4072, 4176, 4270, 4309, 4340, 4348, 4373], 'GC-MS': [7, 198, 403, 1638, 3923], 'analysis': [8, 199, 1011, 1791, 1991, 2534, 2637, 2840, 3710, 3939, 4018], 'was': [9, 200, 595, 812, 923, 1748, 1797, 2221, 2253, 2285, 2310, 2411, 2427, 2440, 2531, 2589, 2632, 2708, 2815, 2997, 3030, 3042, 3075, 3093, 3098, 3107, 3114, 3208, 3294, 3363, 3390, 3411, 3417, 3449, 3463, 3477, 3491, 3521, 3552, 3556, 3562, 3657, 3670, 3750, 3810, 3883, 3959, 3986, 4065, 4091, 4107, 4117, 4131, 4142, 4163, 4198, 4203, 4208, 4268, 4290, 4307], 'developed': [10, 201, 387, 1890], 'and': [11, 21, 41, 49, 75, 97, 100, 113, 115, 139, 156, 176, 181, 202, 212, 232, 240, 266, 288, 291, 304, 306, 330, 347, 368, 373, 388, 460, 464, 514, 576, 592, 603, 608, 611, 615, 624, 656, 663, 756, 763, 789, 827, 891, 905, 933, 942, 974, 1007, 1014, 1047, 1154, 1171, 1216, 1223, 1233, 1250, 1258, 1283, 1297, 1307, 1331, 1368, 1409, 1415, 1434, 1471, 1514, 1527, 1566, 1574, 1597, 1625, 1644, 1650, 1717, 1723, 1757, 1769, 1776, 1805, 1826, 1851, 1863, 1885, 1990, 2007, 2064, 2074, 2098, 2135, 2202, 2216, 2237, 2247, 2273, 2282, 2299, 2308, 2317, 2407, 2437, 2455, 2460, 2466, 2478, 2491, 2514, 2548, 2567, 2599, 2601, 2609, 2615, 2628, 2640, 2669, 2687, 2702, 2730, 2762, 2862, 2931, 2938, 2943, 2970, 3012, 3025, 3039, 3064, 3081, 3095, 3111, 3151, 3171, 3188, 3199, 3205, 3370, 3380, 3401, 3427, 3432, 3439, 3454, 3459, 3470, 3527, 3530, 3546, 3558, 3569, 3576, 3592, 3608, 3620, 3623, 3642, 3655, 3714, 3737, 3772, 3778, 3780, 3824, 3837, 3854, 3869, 3879, 3886, 3925, 3927, 3969, 3978, 3993, 4006, 4041, 4050, 4067, 4124, 4153, 4160, 4188, 4196, 4205, 4227, 4251, 4314, 4322, 4328, 4333, 4365], 'validated': [12, 203, 389], 'for': [13, 164, 204, 355, 393, 470, 1548, 1623, 1721, 1861, 1921, 2432, 2471, 2533, 2611, 2800, 2821, 2838, 2999, 3087, 3148, 3168, 3197, 3287, 3523, 3672, 3702, 3815, 3845, 3916, 3922, 3938, 4017, 4077, 4094, 4122, 4165, 4248, 4276, 4343], 'quantification': [14, 205, 506, 2612, 2724, 2754], 'of': [15, 18, 83, 95, 128, 179, 206, 209, 274, 286, 319, 371, 397, 423, 431, 479, 640, 670, 687, 720, 787, 810, 824, 907, 915, 935, 968, 996, 1012, 1041, 1107, 1136, 1174, 1221, 1248, 1281, 1303, 1333, 1400, 1413, 1436, 1503, 1525, 1544, 1564, 1656, 1679, 1687, 1715, 1730, 1737, 1755, 1767, 1782, 1790, 1802, 1809, 1824, 1840, 1845, 1849, 1879, 1917, 1954, 2028, 2036, 2070, 2100, 2167, 2177, 2182, 2320, 2355, 2363, 2390, 2452, 2487, 2496, 2520, 2535, 2538, 2544, 2585, 2597, 2606, 2613, 2626, 2638, 2646, 2663, 2674, 2795, 2823, 2894, 2941, 2968, 3010, 3019, 3047, 3067, 3119, 3128, 3139, 3142, 3175, 3194, 3257, 3265, 3323, 3331, 3361, 3368, 3377, 3395, 3399, 3404, 3423, 3475, 3488, 3495, 3505, 3540, 3549, 3567, 3588, 3600, 3605, 3611, 3628, 3640, 3653, 3665, 3675, 3711, 3745, 3766, 3770, 3775, 3788, 3797, 3830, 3843, 3877, 3894, 3935, 3965, 3983, 3987, 3990, 3996, 4014, 4059, 4063, 4147, 4151, 4156, 4184, 4257, 4262, 4287, 4331, 4336, 4352, 4368], 'sulfate': [16, 207, 715, 864, 1335, 1370, 1438, 1473, 1881, 1925, 1956, 2102, 2137, 2826, 2864], 'esters': [17, 208, 3639, 3677, 3937, 4016], 'pregnenolone': [19, 210, 599, 863, 1924, 1955], '(PREG-S)': [20, 211], 'dehydroepiandrosterone': [22, 213, 601, 714, 970, 1043, 1334, 1437, 1880, 2101, 2969], '(DHEA-S)': [23, 214], 'in': [24, 47, 55, 59, 118, 170, 183, 215, 238, 246, 250, 309, 362, 375, 399, 433, 475, 507, 693, 821, 857, 866, 912, 926, 972, 1003, 1045, 1067, 1155, 1177, 1201, 1212, 1253, 1256, 1259, 1273, 1286, 1300, 1336, 1372, 1417, 1421, 1439, 1475, 1522, 1569, 1572, 1575, 1591, 1599, 1614, 1627, 1633, 1689, 1713, 1774, 1793, 1837, 1853, 1882, 1957, 1985, 2038, 2067, 2103, 2139, 2223, 2332, 2365, 2413, 2498, 2580, 2587, 2623, 2635, 2643, 2689, 2725, 2728, 2755, 2779, 2835, 2841, 2866, 2934, 3014, 3044, 3057, 3116, 3131, 3172, 3234, 3267, 3300, 3333, 3409, 3507, 3513, 3537, 3573, 3632, 3647, 3742, 3812, 3825, 3840, 3864, 3962, 4035, 4056, 4144, 4223, 4266], 'rat': [25, 48, 216, 239, 1028, 1068, 1140, 1202, 1214, 1337, 1374, 1440, 1477, 1592, 1634, 1775, 1883, 1958, 1986, 2104, 2141, 2521, 2868, 3015, 3020, 3129, 3176, 3195], 'brain.': [26, 51, 217, 242, 1190, 1269, 1778, 3016], 'Using': [27, 218], 'a': [28, 219, 568, 742, 807, 969, 1042, 1139, 1195, 1219, 1401, 1504, 1927, 2168, 2419, 2422, 2664, 2690, 2719, 2808, 2818, 2895, 3058, 3126, 3132, 3165, 3191, 3355, 3480, 3582, 3753, 3791, 3846, 3972], 'solid-phase': [29, 220, 457], 'extraction': [30, 221, 458, 2324, 3097, 4207], 'recycling': [31, 222, 3482, 4313], 'protocol,': [32, 223], 'the': [33, 70, 173, 184, 224, 261, 365, 376, 480, 641, 668, 688, 721, 747, 815, 822, 867, 887, 903, 908, 913, 921, 936, 997, 1004, 1065, 1178, 1213, 1277, 1304, 1373, 1410, 1476, 1523, 1541, 1545, 1620, 1654, 1657, 1731, 1734, 1738, 1753, 1764, 1787, 1800, 1814, 1838, 1858, 2071, 2140, 2438, 2456, 2479, 2508, 2545, 2549, 2603, 2636, 2661, 2671, 2703, 2792, 2798, 2824, 2832, 2842, 2867, 2935, 3002, 3008, 3033, 3040, 3096, 3112, 3173, 3295, 3366, 3387, 3414, 3428, 3443, 3447, 3457, 3460, 3489, 3492, 3499, 3544, 3579, 3633, 3648, 3673, 3735, 3803, 3826, 3833, 3963, 3994, 3997, 4046, 4068, 4087, 4102, 4129, 4136, 4140, 4161, 4181, 4206, 4225, 4236, 4271, 4295, 4300, 4317, 4350, 4374], 'results': [34, 225, 898, 1271, 1761], 'show': [35, 226, 1819], 'that': [36, 69, 227, 260, 889, 1733, 1763, 1796, 1821, 2330, 3232, 3298, 3354, 3908, 3955, 4128], 'little': [37, 228], 'or': [38, 149, 229, 340, 528, 628, 1027, 2797, 3818, 3828, 4111, 4259], 'no': [39, 230], 'PREG-S': [40, 231, 655, 811, 819, 890, 1282, 1414, 1513, 1624, 1722, 1756, 1862, 2234, 2614, 3011, 3189, 3878, 3977], 'DHEA-S': [42, 233, 657, 892, 1284, 1416, 1515, 1626, 1724, 1758, 1864, 2238, 3013, 3880], '(<1': [43, 234], 'pmol/g)': [44, 235], 'is': [45, 236, 467, 716, 1926, 2326, 4033], 'present': [46, 237, 1521, 1773], 'mouse': [50, 241, 986, 1777], 'These': [52, 103, 243, 294, 1270, 1536, 2683, 2713, 2776, 3121], 'data': [53, 141, 244, 332], 'are': [54, 78, 123, 133, 245, 269, 314, 324, 619, 658, 667, 893, 1104, 1272, 1610, 1771, 1828, 2502], 'agreement': [56, 247, 1618, 2780], 'with': [57, 74, 110, 248, 265, 301, 589, 1016, 1540, 1612, 1619, 1866, 1888, 2483, 2781, 3001, 3005, 3125, 3146, 3164, 3358, 3373, 3392, 3420, 3434, 3465, 3502, 3564, 3585, 3597, 3662, 3763, 3785, 3794, 3881, 3914, 3971, 4086, 4109, 4115, 4138, 4235, 4282, 4292, 4304, 4311], 'studies': [58, 249, 883, 1192, 1795], 'which': [60, 251, 455, 1103, 3416], 'steroid': [61, 90, 252, 281, 1783, 2825, 3105, 3676], 'sulfates': [62, 253, 1784], 'were': [63, 254, 1516, 1639, 1651, 1719, 2208, 2241, 2276, 2302, 2319, 2405, 2443, 2458, 2476, 2481, 2512, 2526, 2577, 2619, 2680, 2685, 2716, 2778, 3023, 3071, 3123, 3144, 3158, 3181, 3430, 3535, 3571, 3595, 3644, 3740, 3783, 3835, 3857, 3872, 4054, 4070, 4158, 4214, 4230, 4246, 4326, 4338, 4371], 'analyzed': [64, 255, 2816], 'without': [65, 76, 256, 267], 'deconjugation.': [66, 257], 'We': [67, 258, 1726, 1818], 'suggest': [68, 259], 'discrepancies': [71, 262], 'between': [72, 154, 263, 345, 512, 818, 2760, 4194], 'analyses': [73, 264], 'deconjugation': [77, 268], 'caused': [79, 270], 'by': [80, 92, 271, 283, 402, 436, 621, 759, 814, 1289, 1637, 1692, 1833, 1961, 1992, 2041, 2210, 2255, 2287, 2304, 2312, 2368, 2447, 2979, 3032, 3161, 3184, 3210, 3270, 3336, 3483, 3497, 3659, 3680, 3705, 3940, 4004, 4019, 4232, 4253], 'internal': [81, 272, 2593], 'contamination': [82, 273], 'brain': [84, 120, 275, 311, 400, 434, 509, 1101, 1141, 1215, 1254, 1288, 1306, 1419, 1570, 1635, 1690, 1855, 1884, 2039, 2073, 2366, 2547, 2598, 2648, 2714, 2727, 2757, 3022, 3130, 3177, 3196, 3268, 3334, 3407], 'extract': [85, 276, 3193, 3408], 'fractions,': [86, 277], 'supposed': [87, 278, 1811], 'contain': [89, 280, 1813], 'sulfates,': [91, 282, 3106], 'lipoidal': [93, 284, 1831, 1847, 2184, 3528, 3593, 3618, 3738, 3804, 3855, 3870, 4105, 4272, 4376], 'forms': [94, 285, 1766], 'PREG': [96, 287, 1768, 1804, 1825, 1850, 2269, 2283, 2639, 3187, 3529, 3619, 3641, 3779, 4288, 4353, 4358, 4369], 'DHEA': [98, 289, 1252, 1568, 1770, 1806, 1827, 1852, 2271, 2274, 2641, 3531, 3621, 3643, 3781, 4360], '(L-PREG': [99, 290, 3622], 'L-DHEA,': [101, 292, 3624], 'respectively).': [102, 293], 'derivatives': [104, 295, 1848, 2185, 3627, 3732, 3782], 'can': [105, 296, 3912], 'be': [106, 297, 661, 1519, 2189], 'acylated': [107, 298], 'very': [108, 299, 468, 1196], 'efficiently': [109, 300], 'heptafluorobutyric': [111, 302, 2294], 'anhydride': [112, 303, 2295], 'triethylamine,': [114, 305], 'their': [116, 129, 168, 307, 320, 360, 604, 664, 828, 1613, 1630, 3917], 'levels': [117, 308, 820, 865, 1280, 1632, 1655], 'rodent': [119, 171, 310, 363, 1418, 1854], '(∼1': [121, 312], 'nmol/g)': [122, 313], 'much': [124, 315], 'higher': [125, 316, 1411, 1652], 'than': [126, 317, 1420, 1653, 2710], 'those': [127, 318], 'unconjugated': [130, 321, 1658, 1803, 4095], 'counterparts.': [131, 322], 'They': [132, 323], 'distinct': [134, 325], 'from': [135, 326, 626, 629, 1534, 1595, 1786, 1830, 2226, 2243, 2278, 2445, 2649, 2660, 2670, 2718, 2789, 2807, 2831, 3509, 3734, 4045, 4101], 'fatty': [136, 327], 'acid': [137, 328, 678, 690, 3638], 'esters,': [138, 329], 'preliminary': [140, 331, 3583], 'do': [142, 333, 884], 'not': [143, 334, 885, 924, 1772, 1965], 'favor': [144, 335, 886], 'structures': [145, 336], 'such': [146, 159, 337, 350, 675, 3975, 4179], 'as': [147, 160, 338, 351, 462, 676, 1138, 1218, 2504, 2591, 2817, 3036, 3297, 3479, 3678, 3859, 3976, 4119, 4180], 'sulfolipids': [148, 339], 'sterol': [150, 341], 'peroxides.': [151, 342], 'Noncovalent': [152, 343], 'interactions': [153, 344], 'steroids': [155, 346, 1296, 1550, 1659, 1740, 2063, 2193, 2268, 3372, 3496, 3594, 3871, 3911, 3968, 3970, 4106, 4126], 'proteolipidic': [157, 348], 'elements,': [158, 349], 'lipoproteins,': [161, 352], 'could': [162, 353, 1856], 'account': [163, 354], 'some': [165, 356, 882, 919, 1061, 3909, 4356], 'experimental': [166, 357, 1711], 'data.Given': [167], 'abundance': [169, 361], 'brain,': [172, 364, 1059, 2522, 2936], 'structural': [174, 366], 'characterization': [175, 367, 934], 'biological': [177, 369, 1172], 'functions': [178, 370], 'L-PREG': [180, 372, 3654, 4250], 'L-DHEA': [182, 374, 3656, 4252], 'central': [185, 377, 481], 'nervous': [186, 378, 482, 530], 'system': [187, 379, 483, 531, 4090, 4239], 'merit': [188, 380], 'considerable': [189, 381], 'attention.': [190, 382], 'data.': [358], 'Given': [359], 'Four': [383], 'years': [384, 2813], 'ago,': [385], 'we': [386], 'an': [390, 424, 684, 717, 1680, 2029, 2356, 2592, 2675, 3258, 3324], 'analytical': [391, 425, 1681, 1746, 2030, 2321, 2357, 3259, 3325], 'procedure': [392, 426, 1682, 2031, 2325, 2358, 3260, 3293, 3326, 3490, 3669], 'measuring': [394], 'trace': [395, 429, 1685, 2034, 2361, 3263, 3329], 'amounts': [396, 430, 1686, 1823, 2035, 2362, 3264, 3330], 'neurosteroids': [398, 432, 474, 1102, 1688, 2037, 2364, 3266, 3332], 'tissue': [401, 435, 1255, 1571, 1691, 2040, 2367, 3269, 3335], '(1Liere': [404, 1660, 2009, 2336, 3238, 3304], 'P.': [405, 415, 492, 547, 559, 561, 635, 850, 1206, 1236, 1323, 1366, 1396, 1426, 1469, 1499, 1552, 1661, 1671, 2010, 2020, 2090, 2133, 2163, 2337, 2347, 2740, 2860, 2890, 2926, 2965, 3239, 3249, 3305, 3315], 'Akwa': [406, 503, 1662, 2011, 2338, 2751, 3240, 3306], 'Y.': [407, 504, 543, 1074, 1134, 1586, 1663, 1871, 1905, 2012, 2339, 2752, 3241, 3307], 'Weill-Engerer': [408, 1664, 2013, 2340, 3242, 3308], 'S.': [409, 486, 707, 957, 1030, 1096, 1356, 1459, 1665, 1979, 2014, 2123, 2341, 2734, 2850, 2961, 3243, 3309, 3930, 4009], 'Eychenne': [410, 493, 1666, 2015, 2342, 2741, 3244, 3310], 'B.': [411, 494, 533, 555, 565, 1667, 2016, 2343, 2742, 3245, 3311], 'Pianos': [412, 495, 1668, 2017, 2344, 2743, 3246, 3312], 'A.': [413, 496, 500, 1076, 1238, 1292, 1554, 1669, 2018, 2059, 2345, 2744, 2748, 3247, 3313, 3691], 'Robel': [414, 634, 849, 1205, 1322, 1365, 1395, 1425, 1468, 1498, 1670, 2019, 2089, 2132, 2162, 2346, 2859, 2889, 2925, 2964, 3248, 3314], 'Sjovall': [416, 1326, 1359, 1429, 1462, 1672, 1980, 2021, 2093, 2126, 2348, 2853, 3250, 3316], 'J.': [417, 553, 563, 771, 841, 976, 1049, 1327, 1360, 1386, 1430, 1463, 1489, 1673, 1981, 2022, 2094, 2127, 2153, 2349, 2854, 2880, 2906, 2922, 2955, 3251, 3317], 'Schumacher': [418, 497, 548, 636, 1674, 2023, 2350, 2745, 3252, 3318], 'M.': [419, 498, 549, 557, 637, 833, 837, 843, 845, 1122, 1130, 1325, 1354, 1358, 1392, 1428, 1457, 1461, 1495, 1588, 1675, 2024, 2092, 2121, 2125, 2159, 2351, 2746, 2848, 2852, 2886, 2908, 2916, 2959, 3253, 3319, 3689], 'Baulieu': [420, 501, 847, 1207, 1328, 1363, 1393, 1431, 1466, 1496, 1676, 2025, 2095, 2130, 2160, 2352, 2749, 2857, 2887, 2923, 2962, 3254, 3320], 'E.E.': [421, 502, 633, 848, 1208, 1329, 1364, 1394, 1432, 1467, 1497, 1677, 2026, 2096, 2131, 2161, 2353, 2750, 2858, 2888, 2924, 2963, 3255, 3321], 'Validation': [422, 1678, 2027, 2354, 3256, 3322], 'measure': [428, 1684, 1801, 2033, 2360, 3262, 3328], 'gas': [437, 1693, 2042, 2369, 3271, 3337, 3941, 4020], 'chromatography-mass': [438, 1694, 2043, 2370, 3272, 3338], 'spectrometry.J.': [439, 1695, 2044, 2371, 3273, 3339], 'Chromatogr.': [440, 1696, 2045, 2372, 3274, 3340, 3717], 'B': [441, 1697, 2046, 2373, 3275, 3341, 3718], 'Biomed.': [442, 1698, 1931, 2047, 2374, 3276, 3342, 3719], 'Sci.': [443, 871, 1341, 1444, 1699, 2048, 2108, 2375, 3277, 3343, 3720], 'Appl.': [444, 1700, 2049, 2376, 3278, 3344, 3721], '2000;': [445, 1701, 2050, 2377, 3279, 3345], '739:': [446, 1702, 2051, 2378, 3280, 3346], '301-312Crossref': [447, 1703, 2052, 2379, 3281, 3347], 'PubMed': [448, 523, 584, 648, 699, 728, 775, 801, 876, 951, 981, 1022, 1054, 1116, 1149, 1185, 1228, 1264, 1315, 1346, 1380, 1449, 1483, 1580, 1605, 1704, 1897, 1936, 1973, 2002, 2053, 2082, 2113, 2147, 2380, 2771, 2874, 2949, 2992, 3282, 3348, 3725, 3902], 'Scopus': [449, 524, 585, 649, 700, 729, 776, 802, 877, 952, 982, 1023, 1055, 1117, 1150, 1186, 1229, 1265, 1316, 1347, 1381, 1450, 1484, 1581, 1606, 1705, 1898, 1937, 1974, 2003, 2054, 2083, 2114, 2148, 2381, 2772, 2875, 2950, 2993, 3283, 3349, 3726, 3903, 3950, 4029], '(148)': [450, 1706, 2055, 2382, 3284, 3350], 'Google': [451, 526, 587, 651, 702, 731, 754, 778, 804, 879, 954, 984, 1025, 1057, 1119, 1152, 1188, 1231, 1267, 1318, 1349, 1383, 1452, 1486, 1583, 1608, 1707, 1900, 1939, 1976, 2005, 2056, 2085, 2116, 2150, 2383, 2774, 2877, 2952, 2995, 3285, 3351, 3728, 3905, 3952, 4031], 'Scholar).': [452, 652, 805, 880, 1511, 1708, 2384, 2775, 3729], 'This': [453, 2630, 3292, 3473, 3748, 4170], 'method,': [454, 3035], 'includes': [456], '(SPE)': [459], 'HPLC': [461], 'fractionation': [463, 3206, 3809], 'purification': [465, 3204, 3674, 4084], 'steps,': [466], 'suitable': [469, 3921], 'quantifying': [471, 3524], 'simultaneously': [472], 'numerous': [473], 'small': [476], 'individual': [477], 'regions': [478, 1302, 2069], '(CNS)': [484], '(2Weill-Engerer': [485, 2733], 'David': [487, 1237, 1553, 2735], 'J.P.': [488, 539, 551, 2736], 'Sazdovitch': [489, 2737], 'V.': [490, 1164, 2738], 'Liere': [491, 546, 2739], 'Delacourte': [499, 2747], 'Neurosteroid': [505, 2753], 'human': [508, 927, 937, 1234, 1305, 2072, 2726, 2756], 'regions:': [510, 2758], 'comparison': [511, 1015, 2759, 3000], "Alzheimer's": [513, 2729, 2761], 'nondemented': [515, 2731, 2763], 'patients.J.': [516, 2764], 'Clin.': [517, 2765], 'Endocrinol.': [518, 2766], 'Metab.': [519, 2767], '2002;': [520, 581, 2768], '87:': [521, 2769], '5138-5143Crossref': [522, 2770], '(287)': [525, 2773], 'Scholar)': [527, 588, 1058, 1153, 1189, 1232, 1268, 1408, 2006, 2175, 2996, 3286, 3352, 3906, 3953, 4032], 'peripheral': [529, 569], '(3Ferzaz': [532], 'Brault': [534], 'E.': [535, 1126, 1128], 'Bourliaud': [536], 'G.': [537, 541, 1166, 2914], 'Robert': [538], 'Poughon': [540], 'Claustre': [542], 'Marguet': [544], 'F.': [545, 783, 1390, 1493, 2157, 2884], 'Nowicki': [550], 'Fournier': [552], 'Marabout': [554], 'Sevrin': [556], 'George': [558], 'Soubrie': [560], 'Benavides': [562], 'Scatton': [564], 'SSR180575': [566], '(7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide),': [567], 'benzodiazepine': [570], 'receptor': [571, 691], 'ligand,': [572], 'promotes': [573], 'neuronal': [574, 672, 761], 'survival': [575], 'repair.J.': [577], 'Pharmacol.': [578, 750], 'Exp.': [579], 'Ther.': [580], '301:': [582], '1067-1078Crossref': [583], '(116)': [586], 'high': [590, 1279], 'sensitivity': [591], 'accuracy.': [593], 'Interest': [594], 'primarily': [596], 'focused': [597], 'on': [598, 612, 861, 1799, 1875, 1913, 1950, 2973, 3212], '(PREG),': [600], '(DHEA),': [602], 'sulfated': [605, 1549, 1739, 1765, 1816, 3369, 3910, 3967, 4049, 4123], 'conjugates': [606, 2642], '(PREG-S': [607], 'DHEA-S,': [609], 'respectively)': [610, 3625], 'progesterone': [613], '(PROG)': [614], 'allopregnanolone': [616], '(3α-hydroxy-5α-pregnan-20-one).': [617], 'Neurosteroids': [618, 1984], 'synthesized': [620, 2254, 4303], 'glial': [622], 'cells': [623], 'neurons': [625], 'cholesterol': [627], 'blood-borne': [630], 'precursors': [631, 2933], '(4Baulieu': [632], 'Neurosteroids:': [638, 853, 1397, 1500, 2164, 2891, 2927], 'beginning': [639], 'story.Int.': [642], 'Rev.': [643], 'Neurobiol.': [644], '2001;': [645, 948, 1146, 1894], '46:': [646], '1-32Crossref': [647], '(21)': [650], 'In': [653, 918, 1617, 3384, 3615, 4316, 4355], 'particular,': [654], 'known': [659], 'neuroactive,': [662], 'major': [665], 'effects': [666, 1399, 1502, 2166, 2893, 2967], 'modulation': [669], 'several': [671, 1710, 3288, 4177], 'membrane': [673], 'receptors,': [674, 758], 'γ-aminobutyric': [677], '(5Majewska': [679], 'M.D.': [680, 705], 'Schwartz': [681], 'R.D.': [682], 'Pregnenolone-sulfate:': [683], 'endogenous': [685, 1815], 'antagonist': [686, 719], 'gamma-aminobutyric': [689], 'complex': [692], 'brain?.Brain': [694], 'Res.': [695, 724, 1145, 1376, 1479, 2143, 2870, 2987], '1987;': [696], '404:': [697], '355-360Crossref': [698], '(305)': [701], 'Scholar,': [703, 779, 955, 1120, 1319, 1350, 1384, 1453, 1487, 1584, 1901, 1940, 1977, 2057, 2086, 2117, 2151, 2878, 2902, 2953], '6Majewska': [704], 'Demirgoren': [706], 'Spivak': [708], 'C.E.': [709], 'London': [710], 'E.D.': [711], 'The': [712, 1745, 1779, 1843, 2179, 2191, 2266, 2291, 2323, 2385, 2474, 2494, 2510, 2528, 2617, 3017, 3073, 3090, 3101, 3202, 3225, 3406, 3425, 3485, 3554, 3560, 3651, 3730, 3851, 3980, 4000, 4038, 4097, 4113, 4200, 4210, 4220, 4279], 'neurosteroid': [713, 1142, 2723], 'allosteric': [718, 744], 'GABAA': [722], 'receptor.Brain': [723], '1990;': [725], '526:': [726], '143-146Crossref': [727], '(427)': [730], 'Scholar),': [732, 755, 985, 1026, 1609], 'N-methyl-d-aspartate': [733], '(7Wu': [734], 'F.S.': [735], 'Gibbs': [736], 'T.T.': [737], 'Farb': [738], 'D.H.': [739, 3687], 'Pregnenolone': [740, 1367, 1470, 2134, 2861], 'sulfate:': [741], 'positive': [743, 816, 2819], 'modulator': [745], 'at': [746, 2429, 2435, 2463, 2468, 3061, 3078, 3084, 3154, 3821, 4074, 4133, 4168, 4218, 4274, 4346], 'N-methyl-D-aspartate': [748], 'receptor.Mol.': [749], '1991;': [751, 2989], '40:': [752], '333-336PubMed': [753], 'σ': [757], 'affecting': [760], 'excitability': [762], 'behavior': [764], '(8Paul': [765], 'S.M.': [766], 'Purdy': [767, 2258], 'R.H.': [768], 'Neuroactive': [769, 784], 'steroids.FASEB': [770], '1992;': [772], '6:': [773, 3900, 3948, 4027], '2311-2322Crossref': [774], '(1470)': [777], '9Rupprecht': [780], 'R.': [781, 965, 1038, 1362, 1465, 2129, 2257, 2399, 2856, 3685], 'Holsboer': [782], 'steroids:': [785], 'mechanisms': [786], 'action': [788], 'neuropsychopharmacological': [790], 'perspectives.Trends': [791], 'Neurosci.': [792], '1999;': [793, 1182, 3722], '22:': [794], '410-416Abstract': [795], 'Full': [796, 798], 'Text': [797, 799], 'PDF': [800], '(597)': [803], 'Notably,': [806], 'physiologic': [808], 'function': [809, 1220], 'suggested': [813], 'correlation': [817], 'hippocampus': [823, 2551], 'aged': [825, 858], 'rats': [826, 859, 973, 1046, 2396], 'spatial': [829], 'memory': [830], 'performance': [831, 856], '(10Vallée': [832], 'Mayo': [834], 'W.': [835], 'Darnaudery': [836], 'Corpechot': [838, 2956], 'C.': [839, 988, 1321, 1352, 1388, 1424, 1455, 1491, 2088, 2119, 2155, 2846, 2882, 2904, 2910, 2920, 2957, 3693], 'Young': [840, 2905], 'Koehl': [842], 'Moal': [844], 'Le': [846, 2402], 'Simon': [851], 'H.': [852, 990, 992, 1088, 1090, 1168, 1944], 'deficient': [854], 'cognitive': [855], 'depends': [860], 'low': [862, 1197, 1542], 'hippocampus.Proc.': [868], 'Natl.': [869, 1339, 1442, 2106], 'Acad.': [870, 1340, 1443, 2107], 'USA.': [872, 1342, 1445, 2109], '1997;': [873, 1225], '94:': [874], '14865-14870Crossref': [875], '(290)': [878], 'However,': [881, 1709], 'concept': [888], 'actually': [894], 'neurosteroids.': [895, 1876, 1914, 1951], 'Indeed,': [896], 'contradictory': [897], 'have': [899, 1063, 1193], 'been': [900, 1743, 3228, 4173], 'obtained': [901, 2242, 2717, 3806, 4222], 'concerning': [902, 2722], 'presence': [904, 1839, 1844, 3827], 'activity': [906, 1173, 1200, 1211], 'hydroxysteroid': [909, 998, 1175, 1198], 'sulfotransferase,': [910], 'implied': [911], 'sulfation': [914], 'free': [916, 1249, 1565, 3371, 3736, 4051, 4125], 'steroid.': [917], 'studies,': [920], 'enzyme': [922, 1066], 'detected': [925], '(11Meloche': [928], 'C.A.': [929, 994], 'Falany': [930], 'C.N.': [931], 'Expression': [932], '3': [938, 2696, 2928, 2971], 'beta-hydroxysteroid': [939], 'sulfotransferases': [940], '(SULT2B1a': [941], 'SULT2B1b).J.': [943], 'Steroid': [944, 1310, 2077, 3897], 'Biochem.': [945, 977, 1050, 1311, 2078, 3898], 'Mol.': [946], 'Biol.': [947], '77:': [949], '261-269Crossref': [950], '(86)': [953], '12Sharp': [956], 'Barker': [958, 1031], 'E.V.': [959, 1032], 'Coughtrie': [960, 1033], 'M.W.': [961, 1034], 'Lowenstein': [962, 1035], 'P.R.': [963, 1036], 'Hume': [964, 1037], 'Immunochemical': [966, 1039], 'characterisation': [967, 1040], 'sulfotransferase': [971, 999, 1044, 1143, 1176, 1199, 1210], 'humans.Eur.': [975, 1048], '1993;': [978, 1051, 2946], '211:': [979, 1052], '539-548Crossref': [980, 1053], '(60)': [983, 1056], '(13Shimizu': [987], 'Fuda': [989], 'Yanai': [991], 'Strott': [993], 'Conservation': [995], 'SULT2B1': [1000], 'gene': [1001], 'structure': [1002, 3630], 'mouse:': [1005], 'pre-': [1006], 'postnatal': [1008], 'expression,': [1009], 'kinetic': [1010], 'isoforms,': [1013], 'prototypical': [1017], 'SULT2A1.Endocrinology.': [1018], '2003;': [1019, 1113, 1933, 1970, 1999], '144:': [1020], '1186-1193Crossref': [1021], '(53)': [1024], '(12Sharp': [1029], 'although': [1060], 'groups': [1062], 'found': [1064, 1517], '(14Shibuya': [1069], 'K.': [1070, 1084, 1124, 1132, 1873, 1911, 1948], 'Takata': [1071], 'N.': [1072, 1078, 1086], 'Hojo': [1073], 'Furukawa': [1075], 'Yasumatsu': [1077], 'Kimoto': [1079], 'T.': [1080, 1082, 1092, 1869, 1903, 1907, 1909, 1942, 1946], 'Enami': [1081], 'Suzuki': [1083], 'Tanabe': [1085, 1125], 'Ishii': [1087], 'Mukai': [1089], 'Takahashi': [1091], 'Hattori': [1093], 'T.A.': [1094, 3932, 4011], 'Kawato': [1095], 'Hippocampal': [1097], 'cytochrome': [1098], 'P450s': [1099], 'synthesize': [1100], 'paracrine': [1105], 'neuromodulators': [1106], 'synaptic': [1108], 'signal': [1109], 'transduction.Biochim.': [1110], 'Biophys.': [1111, 2986], 'Acta.': [1112], '1619:': [1114], '301-316Crossref': [1115], '(120)': [1118], '15Shimada': [1121], 'Yoshinari': [1123], 'Shimakawa': [1127], 'Kobashi': [1129], 'Nagata': [1131], 'Yamazoe': [1133], 'Identification': [1135], 'ST2A1': [1137], 'mRNA.Brain': [1144], '920:': [1147], '222-225Crossref': [1148], '(32)': [1151, 1938], 'frog': [1156, 1179], '(16Beaujean': [1157], 'D.': [1158], 'Mensah-Nyagan': [1159], 'A.G.': [1160], 'Do-Rego': [1161], 'J.L.': [1162], 'Luu-The': [1163], 'Pelletier': [1165], 'Vaudry': [1167], 'Immunocytochemical': [1169], 'localization': [1170], 'brain.J.': [1180], 'Neurochem.': [1181, 1601], '72:': [1183], '848-857Crossref': [1184], '(61)': [1187], 'Other': [1191], 'reported': [1194, 1278, 2331, 3907], '(17Rajkowski': [1203], 'K.M.': [1204], 'Hydroxysteroid': [1209], 'liver': [1217, 2559], 'age': [1222], 'sex.Steroids.': [1224], '62:': [1226], '427-436Crossref': [1227], '(68)': [1230], '(18Knapstein': [1235, 1551], 'Wu': [1239, 1555], 'C.H.': [1240, 1556], 'Archer': [1241, 1557], 'D.F.': [1242, 1558], 'Flickinger': [1243, 1559], 'G.L.': [1244, 1560], 'Touchstone': [1245, 1561, 3885], 'J.C.': [1246, 1562, 3889], 'Metabolism': [1247, 1563], 'sulfoconjugated': [1251, 1567], 'vivo': [1257, 1573], 'vitro.Steroids.': [1260, 1576], '1968;': [1261, 1577], '11:': [1262, 1578], '885-896Crossref': [1263, 1579], '(80)': [1266, 1582], 'apparent': [1274], 'contradiction': [1275], 'measured': [1285, 1636], 'mammalian': [1287], 'RIA': [1290, 2839], '(19Lanthier': [1291], 'Patwardhan': [1293, 2060], 'V.V.': [1294, 2061], 'Sex': [1295, 2062], '5-en-3': [1298, 2065], 'beta-hydroxysteroids': [1299, 2066], 'specific': [1301, 2068], 'cranial': [1308, 2075], 'nerves.J.': [1309, 2076], '1986;': [1312, 2079], '25:': [1313, 2080], '445-449Crossref': [1314, 2081], '(169)': [1317, 2084], '20Corpéchot': [1320, 2087], 'Axelson': [1324, 1357, 1427, 1460, 2091, 2124, 2851], 'Characterization': [1330, 1433, 2097], 'measurement': [1332, 1435, 2099], 'brain.Proc.': [1338, 1441, 2105], '1981;': [1343, 1446, 2110], '78:': [1344, 1447, 2111], '4704-4707Crossref': [1345, 1448, 2112], '(601)': [1348, 1451, 2115], '21Corpéchot': [1351, 1454, 2118], 'Synguelakis': [1353, 1456, 2120, 2847], 'Talha': [1355, 1458, 2122, 2849], 'Vihko': [1361, 1464, 2128, 2855], 'its': [1369, 1472, 2136, 2863, 2932, 3991], 'ester': [1371, 1474, 2138, 2865], 'brain.Brain': [1375, 1478, 2142, 2869], '1983;': [1377, 1480, 2144, 2871], '270:': [1378, 1481, 2145, 2872], '119-125Crossref': [1379, 1482, 2146, 2873], '(354)': [1382, 1485, 2149, 2876], '22Young': [1385, 1488, 2152, 2879], 'Corpéchot': [1387, 1490, 2154, 2881], 'Perché': [1389, 1492, 2156, 2883], 'Haug': [1391, 1494, 2158, 2885, 2958], 'pharmacological': [1398, 1501, 2165, 2892], '3beta-hydroxy-steroid': [1402, 1505, 2169, 2896], 'dehydrogenase': [1403, 1506, 2170, 2897], 'inhibitor.Endocrine.': [1404, 1507, 2171, 2898], '1994;': [1405, 1508, 2172, 2899], '2:': [1406, 1509, 2173, 2900], '505-509Google': [1407, 1510, 2174, 2901], 'concentrations': [1412, 3504], 'blood': [1422, 1596, 2410, 2805], '(20Corpéchot': [1423], 'Moreover,': [1512], 'still': [1520, 2186], 'brains': [1524, 1959, 2387], 'castrated': [1526, 2980], 'adrenalectomized': [1528], 'male': [1529, 2394, 2654, 2942, 2981], 'rats,': [1530], 'whereas': [1531, 4299], 'they': [1532], 'disappeared': [1533], 'plasma.': [1535, 2539], 'latter': [1537, 4318], 'results,': [1538], 'together': [1539], 'permeability': [1543], 'blood-brain': [1546], 'barrier': [1547], '23Kishimoto': [1585], 'Hoshi': [1587], 'Dehydroepiandrosterone': [1589], 'sulphate': [1590, 3936, 4015], 'brain:': [1593, 1987], 'incorporation': [1594], 'metabolism': [1598], 'vivo.J.': [1600], '1972;': [1602], '19:': [1603], '2207-2215Crossref': [1604], '(47)': [1607], 'consistent': [1611], 'situ': [1615], 'synthesis.': [1616], 'concentration': [1621], 'range': [1622], 'these': [1628, 1846, 2183, 4341], 'reports,': [1629], 'average': [1631], '8.3': [1640], '±': [1641, 1646, 2553, 2561, 2571], '0.80': [1642], 'ng/g': [1643], '2.5': [1645], '0.27': [1647], 'ng/g,': [1648], 'respectively,': [1649, 4053], 'oddities': [1712], 'terms': [1714], 'reproducibility': [1716], 'linearity': [1718], 'observed': [1720, 1860], 'measurements.': [1725], 'also': [1727, 2578, 2633, 2681, 3645], 'became': [1728], 'aware': [1729], 'fact': [1732], 'chemical': [1735, 2180], 'identity': [1736], 'had': [1741], 'never': [1742], 'established.': [1744], 'protocol': [1747, 2530, 2631, 2829, 3226, 3520], 'thus': [1749], 'modified': [1750], 'improve': [1752], 'reliability': [1754], 'quantification.': [1759], 'Our': [1760], 'demonstrate': [1762], 'previous': [1780, 2334, 2720, 3236], 'detection': [1781, 3009], 'resulted': [1785], 'indirect': [1788, 2008], 'used': [1792, 2532, 2579, 2834, 2998, 3671, 4092, 4247], 'earlier': [1794], 'based': [1798], 'after': [1807, 3790, 3807], 'hydrolysis': [1808], 'fractions': [1810, 3739, 3856, 4044, 4325, 4342], 'conjugates.': [1817], 'here': [1820], 'large': [1822], 'derivatized': [1829, 3873, 4108], 'complexes': [1832], 'acylation': [1834], 'derivatization': [1835, 2292, 3934, 4013, 4244], 'reaction': [1836, 3958, 3985, 4001, 4114, 4137, 4171, 4186, 4280], 'triethylamine': [1841], '(TEA).': [1842], 'explain': [1857], 'variations': [1859], 'measurements': [1865], 'direct': [1867], '(24Higashi': [1868], 'Daifu': [1870, 1904], 'Shimada': [1872, 1910, 1947], 'Studies': [1874, 1912, 1949], 'XIV.': [1877], 'Levels': [1878, 1953], 'serum': [1886], 'determined': [1887, 1960], 'newly': [1889], 'enzyme-linked': [1891, 1918, 1962], 'immunosorbent': [1892, 1919, 1963], 'assay.Steroids.': [1893], '66:': [1895], '865-874Crossref': [1896], '(19)': [1899], '25Higashi': [1902], 'Ikeshima': [1906], 'Yagi': [1908, 1945], 'XV.': [1915], 'Development': [1916], 'assay': [1920, 1964], 'examining': [1922], 'whether': [1923], 'veritable': [1928], 'neurosteroid.J.': [1929], 'Pharm.': [1930, 1968], 'Anal.': [1932], '30:': [1934], '1907-1917Crossref': [1935], '26Higashi': [1941], 'Sugitani': [1943], 'XVI.': [1952], 'requiring': [1966, 2791], 'solvolysis.Biol.': [1967], 'Bull.': [1969], '26:': [1971], '709-711Crossref': [1972], '(39)': [1975], '27Liu': [1978], 'Griffiths': [1982], 'W.J.': [1983], 'extraction,': [1988], 'isolation,': [1989], 'nanoscale': [1993], 'liquid': [1994], 'chromatography-electrospray': [1995], 'mass': [1996, 3708, 3943, 4022], 'spectrometry.Anal.': [1997], 'Chem.': [1998], '75:': [2000], '5835-5846Crossref': [2001], '(124)': [2004], '19Lanthier': [2058], 'methods': [2176], 'analysis.': [2178], 'identities': [2181], 'need': [2187], 'elucidated.': [2190], 'radioactive': [2192], '[3H]PREG': [2194, 2203, 2227, 3147, 3163], '([7-3H]PREG;': [2195, 2205], '25': [2196, 2206, 2219], 'Ci/mmol),': [2197, 2201], '[3H]DHEA-S': [2198], '([1,2,6,7-3H]DHEA-S;': [2199], '92.5': [2200], 'palmitate': [2204], 'Ci/mmol)': [2207, 2220], 'supplied': [2209, 2286, 2311], 'New': [2211], 'England': [2212], 'Nuclear': [2213], '(Boston,': [2214], 'MA),': [2215], '[3H]PREG-S': [2217], '([7-3H]PREG-S;': [2218], 'prepared': [2222, 3733], 'our': [2224, 2333, 2836, 3235, 3301], 'laboratory': [2225, 2837], 'using': [2228, 4294], 'pyridine': [2229], 'sulfur': [2230], 'trioxide.': [2231], 'PREG,': [2232], 'DHEA,': [2233], '(potassium': [2235], 'salt),': [2236], '(sodium': [2239], 'salt)': [2240, 2252], 'Roussel-Uclaf': [2244], '(Romainville,': [2245], 'France),': [2246, 2701], 'tetradeuterated': [2248], '[2H4]PREG-S': [2249, 2586, 3063], '([17,21,21,21-2H4]PREG-S;': [2250], 'trimethylammonium': [2251], 'Dr.': [2256], '(The': [2259], 'Scripps': [2260], 'Research': [2261], 'Institute,': [2262], 'La': [2263], 'Jolla,': [2264], 'CA).': [2265], 'nonpolar': [2267], 'palmitate,': [2270, 4359], 'stearate,': [2272], 'acetate': [2275], 'purchased': [2277], 'Sigma': [2279], '(Saint-Louis,': [2280], 'MO),': [2281], 'tosylate': [2284, 4370], 'Steraloids': [2288], '(Newport,': [2289], 'RI).': [2290], 'reagents': [2293, 2316, 4245], '(HFBA),': [2296], 'N-methyl-N-trimethylsilyltrifluoroacetamide': [2297], '(MSTFA),': [2298], 'methoxyamine': [2300, 4263, 4305], 'hydrochloride': [2301, 4264, 4306], 'provided': [2303], 'Pierce': [2305], '(Rockford,': [2306], 'IL),': [2307], 'TEA': [2309, 4152], 'Sigma.': [2313], 'All': [2314], 'other': [2315, 3041, 4243], 'solvents': [2318, 3814], 'grade.': [2322], 'roughly': [2327], 'similar': [2328], 'paper': [2335, 3237, 3303], 'entire': [2386, 2550], '(∼2': [2388], 'g)': [2389], '2': [2391, 2650, 3065], 'month': [2392, 2651], 'old': [2393, 2652, 2667, 2678], 'Sprague-Dawley': [2395], '[Centre': [2397], "d'Elevage": [2398], 'Janvier,': [2400], '(CERJ),': [2401], 'Genest': [2403], 'St-Isle]': [2404], 'removed': [2406, 3094], 'weighed.': [2408], 'Rat': [2409], 'sampled': [2412], 'heparinized': [2414], 'polypropylene': [2415], 'Falcon': [2416], 'tubes': [2417], 'through': [2418], 'funnel': [2420], 'containing': [2421, 3054, 3104, 4048, 4104], 'heparin-treated': [2423], 'gauze': [2424], 'filter.': [2425], 'Blood': [2426], 'centrifuged': [2428, 2467, 2492, 3083], '3,000': [2430, 2469, 3085], 'g': [2431, 2470, 3086], '10': [2433, 2449, 2484], 'min': [2434, 3817, 4167, 4345], '4°C,': [2436], 'plasma': [2439, 2600], 'collected.': [2441], 'Steroids': [2442], 'extracted': [2444, 2482, 3031], 'tissues': [2446, 2715], 'adding': [2448, 3185], 'volumes': [2450, 2485, 3066], '(w/v)': [2451, 2486], 'methanol': [2453], '(MeOH),': [2454], 'samples': [2457, 3570, 3834, 4069], 'sonicated': [2459], 'left': [2461, 3076], 'overnight': [2462, 3077], 'room': [2464, 3079, 4075], 'temperature': [2465, 3080, 4076, 4130], '5': [2472, 3088, 3359, 3374, 3393, 3397, 3402, 3421, 3547, 3565, 3586, 3598, 3603, 3609, 3663, 3764, 3768, 3773], 'min.': [2473, 3089, 4079, 4278], 'supernatants': [2475, 2511], 'collected,': [2477, 4327], 'residues': [2480], 'MeOH/CHCl3': [2488, 3612, 3634, 4098, 4323], '(1:1,': [2489], 'v/v)': [2490], 'again.': [2493], 'proportions': [2495, 2506], 'solvent': [2497, 2500], 'all': [2499], 'mixtures': [2501], 'given': [2503], 'volume': [2505], 'throughout': [2507], 'article.': [2509], 'combined,': [2513], 'aliquots': [2515, 2543, 2596, 2659], 'corresponding': [2516], '100': [2518, 4057, 4145, 4260, 4334, 4366], 'mg': [2519, 2645, 3141], 'unless': [2523], 'otherwise': [2524], 'stated,': [2525], 'analyzed.': [2527, 2682], 'same': [2529, 3296, 3444, 3461, 3649], '1': [2536, 2624, 3045, 3117, 3538, 3743, 3841], 'ml': [2537, 2625, 3046, 3118, 3360, 3375, 3394, 3398, 3403, 3422, 3539, 3548, 3566, 3587, 3599, 3604, 3610, 3664, 3744, 3765, 3769, 3774, 3787, 3796, 3842], 'One': [2540, 2656], 'hundred': [2541, 2657], 'milligram': [2542, 2658], 'anterior': [2546, 3021], '(144.5': [2552], '13.0': [2554], 'mg;': [2555, 2563, 2573], 'n': [2556, 2564, 2574], '=': [2557, 2565, 2575], '5),': [2558, 2566], '(340.8': [2560], '77.4': [2562], 'adrenal': [2568], 'glands': [2569, 2940], '(38.9': [2570], '6.2': [2572], '5)': [2576], 'this': [2581, 3385, 3616, 3801, 3956, 3984], 'study.': [2582], 'Two': [2583, 4242], 'nanograms': [2584], 'MeOH': [2588, 3410, 3506, 3844], 'added': [2590, 4269, 4339, 4372], 'standard': [2594, 3003, 3034], 'total': [2604], 'extracts': [2605, 2618, 4213], 'hippocampus,': [2607], 'liver,': [2608], 'adrenals': [2610], 'DHEA-S.': [2616, 3979], 'dried,': [2620], 'taken': [2621, 3108, 3838], 'up': [2622, 3839], 'MeOH,': [2627, 3396, 3541], 'sonicated.': [2629], 'applied': [2634, 3412, 3441, 3542, 3577, 3751], '150': [2644], 'whole': [2647], 'Swiss': [2653], 'mice.': [2655, 2982], 'cerebellum': [2662], '91': [2665], 'year': [2666, 2677], 'man': [2668, 2811], 'frontal': [2672], 'cortex': [2673], '88': [2676], 'woman': [2679], 'patients': [2684, 2732, 2796], 'hospitalized': [2686], 'died': [2688], 'geriatric': [2691], 'unit': [2692], '(Service': [2693], 'de': [2694], 'Gérontologie,': [2695], 'Hôpital': [2697], 'Emile': [2698], 'Roux,': [2699], 'Limeil-Brévannes,': [2700], 'postmortem': [2704], 'delay': [2705], 'before': [2706, 3365], 'dissection': [2707], 'less': [2709], '24': [2711, 3200, 3819], 'h.': [2712, 3201], 'study': [2721], 'investigations': [2777], 'French': [2782, 2785], 'legislation': [2783], '(the': [2784], 'bioethic': [2786], 'Huriet': [2787], 'law': [2788], '1994)': [2790], 'explicit': [2793], 'consent': [2794], 'family': [2799], 'medical': [2801], 'research': [2802], 'purposes.': [2803], 'healthy': [2809], 'adult': [2810], '(50': [2812], 'old)': [2814], 'control': [2820], 'validation': [2822], 'methodology.': [2827], 'derived': [2830], 'techniques': [2833], 'period': [2843], '1980–1995': [2844], '(21Corpéchot': [2845], '28Corpechot': [2903], 'Calvel': [2907], 'Wehrey': [2909], 'Veltz': [2911], 'J.N.': [2912], 'Touyer': [2913], 'Mouren': [2915], 'Prasad': [2917], 'V.V.K.': [2918], 'Banner': [2919], 'Sjövall': [2921], 'alpha-hydroxy-5': [2929], 'alpha-pregnan-20-one': [2930], 'plasma,': [2937], 'steroidogenic': [2939], 'female': [2944, 2977], 'rats.Endocrinology.': [2945], '133:': [2947], '1003-1009Crossref': [2948], '(0)': [2951], '29Young': [2954], 'Gobaille': [2960], 'Suppressive': [2966], 'beta-methyl-androst-5-en-17-one': [2972], 'attack': [2974], 'towards': [2975], 'lactating': [2976], 'intruders': [2978], 'II.': [2983], 'Brain': [2984], 'neurosteroids.Biochem.': [2985], 'Commun.': [2988], '174:': [2990], '892-897Crossref': [2991], '(65)': [2994], 'regard': [3006], 'halves': [3018], 'dissected': [3024], 'weighed': [3026], '(∼650': [3027], 'mg).': [3028], 'One-half': [3029], 'described': [3037, 3233, 3299, 3860, 4120, 4240], 'above,': [3038], 'homogenized': [3043], 'PBS': [3048], 'buffer': [3049, 3135], '(10': [3050, 4362], 'mM,': [3051], 'pH': [3052], '7.4)': [3053], '0.8%': [3055], 'NaCl': [3056], 'Teflon/glass': [3059], 'homogenizer': [3060], '4°C.': [3062], 'ethyl': [3068], 'acetate-isooctane': [3069], '(1:1)': [3070, 3379, 3635, 4040, 4089, 4099, 4238, 4297, 4324], 'added.': [3072, 3553], 'mixture': [3074, 4162], 'then': [3082, 3418], 'organic': [3091, 4201, 4212], 'phase': [3092, 4202], 'repeated': [3099, 3464], 'twice.': [3100], 'aqueous': [3102], 'phase,': [3103], 'dryness,': [3110], 'residue': [3113, 4141], 'dissolved': [3115, 3536, 3572, 3741, 3811, 4055, 4143], 'MeOH.': [3120, 3405, 3424], 'experiments': [3122, 3157, 3180], 'performed': [3124, 4118], 'homogenate': [3127, 3143, 3167], 'Tris': [3133], 'hypotonic': [3134], '(pH': [3136], '7.4).': [3137], 'Aliquots': [3138], '∼300': [3140], 'incubated': [3145], '1,': [3149, 3866], '4,': [3150], '48': [3152], 'h': [3153, 3170, 3820], '37°C.': [3155], 'Control': [3156], 'carried': [3159, 3182], 'out': [3160, 3183], 'incubating': [3162], 'boiled': [3166], '4': [3169, 3795], 'absence': [3174, 3829], 'homogenate.': [3178], 'Analogous': [3179], 'tritiated': [3186], 'methanolic': [3192], '0': [3198], 'first': [3203], 'step': [3207, 3357, 3793, 4085, 4193], 'achieved': [3209], 'SPE': [3211, 3519, 3668, 3808, 3849, 4047, 4083, 4103, 4234, 4293, 4310, 4375], 'C18': [3213, 3388, 3500, 3754, 3848, 4082, 4233], 'columns': [3214], '(500': [3215], 'mg,': [3216], '6': [3217, 3786], 'ml;': [3218], 'International': [3219], 'Sorbent': [3220, 3757], 'Technology,': [3221], 'Mid': [3222], 'Glamorgan,': [3223], 'UK).': [3224], 'has': [3227, 4172], 'changed': [3229], 'relative': [3230, 4182], 'reasons': [3289], 'explained': [3290], 'below.': [3291], 'recent': [3302], 'except': [3353, 4127], 'washing': [3356, 3429, 3792], 'water': [3362, 3435, 3508, 4195], 'introduced': [3364], 'elution': [3367, 3661], 'each': [3376], 'MeOH/water': [3378, 3381, 3437, 3452, 3466, 3468, 3550, 3574, 3601, 3606, 4039, 4042, 4320], '(9:1),': [3382, 3607], 'respectively.': [3383, 3614], 'system,': [3386, 4298], 'cartridge': [3389, 3501, 3755], 'conditioned': [3391, 3762], 'water,': [3400, 3568, 3589, 3771], 'cartridge,': [3415, 3458, 3545], 'washed': [3419], 'flow-through': [3426, 3448, 3555], 'combined': [3431, 4211], 'diluted': [3433, 3450], '(8:2)': [3438], 'again': [3440], 'cartridge.': [3445, 3580], 'Then,': [3446, 3832], '(6:4)': [3453], 'reapplied': [3455], 'process': [3462], '(4:6),': [3467], '(2:8),': [3469], 'finally': [3471], 'water.': [3472], 'sequence': [3474], 'adsorptions': [3476], 'defined': [3478], 'SPE.': [3484], 'second': [3486, 3847], 'part': [3487], 'stepwise': [3493], 'recovery': [3494, 3652], 'eluting': [3498], 'increasing': [3503], '0%': [3510], '100%': [3512], '5%': [3514], 'increments.': [3515], 'simplified': [3517, 4312], 'recycling/elution': [3518], 'established': [3522], 'sulfated,': [3525, 3590, 3852, 3867], 'unconjugated,': [3526, 3853, 3868], '(Fig.': [3532], '1).': [3533], 'Samples': [3534], '(85:15)': [3551], 'collected': [3557, 3858], 'dried.': [3559], 'column': [3561], 'reconditioned': [3563], '(2:8)': [3575], 'After': [3581], 'wash': [3584], 'free,': [3591], 'eluted': [3596, 3631, 3646, 3784], '(1:1),': [3602, 3613, 3777], 'paper,': [3617], 'designate': [3626], 'unknown': [3629], 'fraction.': [3636, 3650], 'Fatty': [3637], 'increased': [3658], 'additional': [3660], 'hexane.': [3666], 'Another': [3667], 'proposed': [3679, 4003], 'Aguilera': [3681], 'et': [3682], 'al.': [3683], '(30Aguilera': [3684], 'Catlin': [3686], 'Becchi': [3688], 'Phillips': [3690], 'Wang': [3692], 'Swerdloff': [3694], 'R.S.': [3695], 'Pope': [3696], 'H.G.': [3697], 'Hatton': [3698], 'C.K.': [3699], 'Screening': [3700], 'urine': [3701], 'exogenous': [3703], 'testosterone': [3704], 'isotope': [3706], 'ratio': [3707], 'spectrometric': [3709], 'one': [3712], 'pregnanediol': [3713], 'two': [3715], 'androstanediols.J.': [3716], '727:': [3723], '95-105Crossref': [3724], '(95)': [3727], 'heptafluorobutyrate': [3731], 'CH3CN/water': [3746, 3776, 3798, 4088, 4237, 4296], '(1:1).': [3747, 3799], 'solution': [3749], '(International': [3756], 'Technology;': [3758], '500': [3759], 'mg)': [3760], 'previously': [3761], 'CH3CN,': [3767], 'CH3CN': [3789], 'For': [3800], 'purpose,': [3802], 'fraction': [3805, 4100, 4273], 'different': [3813, 3822], '30': [3816, 4078, 4166, 4277, 4344], 'temperatures': [3823], 'light.': [3831], 'dried': [3836, 4215], 'fractionation.': [3850, 4315], 'above.': [3861, 4241], 'As': [3862], 'shown': [3863], 'Fig.': [3865, 4036], 'separately.': [3874], 'Simultaneous': [3875], 'hydrolysis/derivatization': [3876], 'HFBA': [3882, 3915, 4064, 4110, 4116, 4157, 4226, 4332], 'investigated.': [3884], 'Dobbins': [3887, 3890], '(31Touchstone': [3888], 'M.F.': [3891], 'Direct': [3892, 3933, 4012], 'determination': [3893], 'steroidal': [3895], 'sulfates.J.': [3896], '1975;': [3899], '1389-1392Crossref': [3901], '(16)': [3904], 'react': [3913], 'conversion': [3918], 'into': [3919], 'heptafluorobutyrates': [3920, 4221], 'analysis,': [3924], 'Murray': [3926, 4005], 'Baillie': [3928, 3931, 4007, 4010], '(32Murray': [3929, 4008], 'chromatography': [3942, 4021], 'spectrometry.Biomed.': [3944, 4023], 'Mass': [3945, 4024], 'Spectrom.': [3946, 4025], '1979;': [3947, 4026], '82-89Crossref': [3949, 4028], '(28)': [3951, 4030], 'showed': [3954], 'single-step': [3957], 'quantitative': [3960], 'only': [3961, 4093], 'case': [3964], 'aromatic': [3966], '3β-sulfoxy-Δ5': [3973], 'structure,': [3974], 'potential': [3981], 'usefulness': [3982], 'interest': [3988], 'because': [3989], 'simplicity': [3992], 'selectivity': [3995], 'hydrolysis/acylation': [3998], 'reaction.': [3999], 'mechanism': [4002], 'schematized': [4034], '2.': [4037], '(9:1)': [4043, 4321], 'steroids,': [4052], 'μl': [4058, 4146, 4150, 4155, 4261, 4330, 4335], 'acetone.': [4060], 'Twenty': [4061], 'microliters': [4062, 4256], 'added,': [4066, 4159], 'allowed': [4071], 'stand': [4073], 'subsequent': [4081], 'steroids.': [4096], 'TEA/HFBA.': [4112], 'above': [4121], 'kept': [4132], '70°C.': [4134, 4169, 4219], 'Concerning': [4135], 'TEA/HFBA,': [4139], 'acetone,': [4148], '20': [4149, 4154, 4329], 'heated': [4164], 'optimized': [4174], 'according': [4175], 'parameters,': [4178], 'amount': [4183], 'reagent,': [4185], 'duration,': [4187], 'temperature.': [4189], 'liquid-liquid': [4191], 'partition': [4192], 'hexane': [4197], 'performed.': [4199], 'removed,': [4204], 'repeated.': [4209], 'under': [4216], 'nitrogen': [4217], 'both': [4224], 'TEA/HFBA': [4228], 'reactions': [4229], 'purified': [4231, 4291], 'analyzing': [4249], 'GC-MS.': [4254], 'Fifty': [4255], 'MSTFA': [4258, 4283], '(2%': [4265], 'pyridine)': [4267], '70°C': [4275, 4347], 'product': [4281], '[i.e.,': [4284], 'trimethylsilyl': [4285], 'ether': [4286], '(PREG-TMS)]': [4289], 'PREG-20-methoxime': [4301], '(PREG-20-MO)': [4302], 'submitted': [4308], 'case,': [4319], 'acetone': [4337], 'form': [4349], '3-heptafluorobutyrate-20-methoxime': [4351], '(PREG-3-HFB-20-MO).': [4354], 'experiments,': [4357], 'stearate': [4361], 'ng': [4363, 4367], 'each),': [4364]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2121753150', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-08T05:04:07.374395', 'created_date': '2016-06-24'}
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