Publication Information

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[82, 122, 162], 'Brigham': [83, 123, 163, 1379], "Women's": [85, 125, 165, 867, 1381], 'Harvard': [87, 127, 167], 'Medical': [88, 128, 168], 'School,': [89, 129, 169], 'Boston,': [90, 130, 170], 'Mass.': [91, 131, 171], ',': [92], 'RidkerPaul': [95], 'Ridker': [97, 1369, 1593, 1849, 2034, 2155, 2471, 2695, 2722, 2792], 'LipGregory': [135], 'Lip': [137, 1750, 2431], 'Originally': [172], 'published1': [173], 'Sep': [174], '2002https://doi.org/10.1161/01.STR.0000029008.00497.D3Stroke.': [175], '2002;33:2141–2143Since': [176], 'their': [177, 270], 'development': [178, 1092], 'approximately': [179], 'a': [180, 191, 221, 387, 395, 503, 558, 631, 742, 811, 850, 931, 952, 1160, 1257, 1263, 1276, 1281, 1315, 1373, 1738, 1756, 1834, 2137, 2325, 2522, 2804, 2988, 3725], 'decade': [181], 'ago,': [182], 'cell': [183, 287, 317, 569, 719, 1034, 1326, 1470, 1518, 1548, 1996, 2087, 2133, 2162, 2226, 2282, 2379, 2474, 2595], 'adhesion': [184, 214, 288, 326, 366, 484, 499, 570, 720, 1327, 1465, 1519, 1549, 1575, 1608, 1705, 1710, 1939, 1997, 2024, 2088, 2134, 2163, 2188, 2219, 2283, 2317, 2351, 2375, 2410, 2436, 2439, 2475, 2514, 2591, 2617, 3718, 3796], 'molecules': [185, 215, 251, 289, 327, 367, 485, 606, 629, 1060, 1550, 1576, 1940, 2025, 2189, 2284, 2318, 2352, 2376, 2411, 2476, 2592, 2618], 'have': [186, 232, 441, 750, 858, 940, 1210, 1223, 1228], 'been': [187, 442, 859, 947], 'attracting': [188], 'interest': [189, 1172], 'number': [192, 396], 'reasons.': [194], 'For': [195], 'example,': [196], 'blockade': [198], 'interaction': [201], 'between': [202, 814, 1114, 3445], 'leukocytes': [203], 'endothelium': [206, 385, 511, 1579, 1707], 'by': [207, 516, 880, 1202, 1378, 1708, 3132, 3305, 3607, 3636], 'agents': [208], 'that': [209, 344, 676, 716, 765, 949, 1222, 1239, 1253, 1308, 1383], 'mimic': [210], 'or': [211, 258, 301, 352, 1003, 1028, 1031, 1324, 1363, 2563], 'inhibit': [212], 'these': [213, 304, 605, 623, 628, 792, 824, 843, 1036, 1123, 1303], 'may': [216, 266, 293, 306, 313, 328, 341, 348, 618, 767, 794], 'provide': [217, 267, 795], 'basis': [219], 'new': [222, 1757, 1835], 'class': [223], 'therapeutic': [225, 2926], 'agents,': [226, 2927], 'although': [227, 383, 538, 864], 'promising': [228], 'studies': [229, 1209], 'animals1–3': [231], 'yet': [233], 'be': [235, 241, 294, 307, 329, 342, 377, 619, 768, 832, 839, 1170, 1199, 1273, 1294, 1347], 'translated': [236], 'into': [237, 269], 'products': [238], 'proven': [239], 'effective': [242], 'humans.': [244], 'Study': [245], 'expression': [248, 603, 1545, 2222, 2254], 'on': [252, 477, 607, 1577, 2190, 2589, 2649, 2891], 'surface': [254], 'various': [256, 355, 574, 755], 'cells': [257, 356, 432, 614], 'soluble': [261, 286, 310, 325, 422, 1325, 1434, 1606, 1709, 1754, 1829, 1962, 1966, 2023, 2160, 2350, 2590, 2616], 'form': [262], 'plasma': [265, 292, 440, 820, 911, 1059, 1116, 1678, 1740], 'insights': [268], 'role(s)': [271], 'pathophysiology': [273, 800, 1128], 'cardiovascular,': [275, 634], 'connective': [276], 'tissue': [277, 1582], 'neoplastic': [279, 637], 'diseases,4,5': [280], 'differences': [282], 'levels': [284, 347, 391, 409, 420, 437, 457, 522, 540, 578, 585, 626, 662, 753, 845, 871, 1681, 2021, 2614, 2683, 3415, 3572], 'useful': [295, 330, 649], 'tools': [296], 'stratifying': [298], 'disease': [299, 638, 711, 906, 1642, 2054, 2739, 3449], 'severity': [300], 'prognosis.6,7': [302], 'However,': [303, 537, 621, 666, 822, 985, 1013], 'aspects': [305], 'related,': [308], 'as': [309, 339, 358, 1336, 1372, 1737, 2136, 2817, 2987, 3576], 'forms': [311, 1878], 'themselves': [312], 'interfere': [314], 'with': [315, 695, 708, 902, 934, 1027, 1086, 1275, 1320, 1921, 2004, 2091, 2289, 2479, 2568, 3023, 3101, 3419, 3424], 'leukocyte/endothelial': [316], 'interactions,': [318], 'at': [319, 972, 1155, 1679], 'least': [320], 'vitro.8,9': [322], 'Despite': [323], 'this,': [324], 'dissecting': [332], 'pathophysiological': [334], 'events': [335], 'cardiovascular': [337, 463, 575, 690, 956, 1094, 1130, 1389, 1862, 2053, 2167, 2738, 3446], 'disease,': [338, 863, 1651, 3271, 3358], 'it': [340], 'presumed': [343], 'changes': [345, 766, 790, 2643], 'relate': [349, 1384], 'activation': [351, 429, 2380, 3537], 'damage': [353, 595, 1471], 'such': [357, 455, 577], 'platelet': [360, 1760], 'endothelium.The': [362], 'selectin': [363, 2406], 'family': [364], 'has': [368, 945, 1140, 1256, 1267], 'two': [369], 'principal': [370], 'members.': [371], 'Soluble': [372, 497, 1672, 1855, 1877, 1909, 2131, 2215, 2316, 2374, 2512, 2982, 3716], 'P-selectin': [373, 1435, 1736, 1755, 1780, 1810, 1830, 1856, 2103], 'is': [374, 502, 553, 557, 668, 740, 951, 1063, 1083, 1234, 1247, 1260, 1291, 1310, 1370, 1674, 1753, 1781, 3020], 'believed': [375], 'product': [379, 505], 'activated': [381, 1703, 1891], 'platelets,': [382], 'displays': [386], 'membrane-bound': [388], 'form.10,11': [389], 'Increased': [390, 1828, 2020, 2613], 'are': [392, 424, 523, 590, 639, 663, 1105, 1111, 1154, 1356, 1884, 2477, 2624], 'found': [393, 524, 715, 907, 1225], 'conditions,': [398, 527], 'including': [399, 509, 528, 1096], 'thrombotic': [400, 1784], 'disorders,': [401], 'diabetes,': [402, 909, 1020], 'ischemic': [404, 452, 1440, 1469, 3102, 3332, 3384, 3483], 'heart': [405, 453, 1943, 1970, 2323, 2656], 'disease,12,13': [406], 'raised': [408, 436, 456, 521, 539, 567, 752, 844, 908], 'predict': [410, 461, 467, 548, 582, 846], 'adverse': [411, 462, 549, 583, 847, 1658], 'events,14': [412], 'even': [413], 'apparently': [415, 1151, 1617, 2741], 'healthy': [416, 544, 1152, 1618, 2742, 3030], 'individuals.15': [417], 'Although': [418], 'increased': [419, 625, 661, 1088, 1782, 1961, 1965], 'E-selectin': [423, 1554, 1967, 1999, 2216], 'result': [426], 'cytokine': [428, 1890, 3571], 'endothelial': [431, 1893, 1937, 2378, 2594, 3026], 'vitro,16': [434, 520], 'reported': [443, 675, 751, 810], 'variant': [445, 1922], '(but': [446], 'not': [447, 939, 1041, 1306, 1357, 1475, 3417], 'stable)': [448], 'angina17': [449, 529], 'disease,18': [454], 'seem': [458, 579, 648], 'unable': [459, 580], 'events19': [464], 'but': [465, 601, 654, 1220, 1474, 3423], 'do': [466, 1122, 1305, 3416], 'restenosis': [468, 2001], 'following': [469, 704, 761, 1831, 2445, 3538], 'percutaneous': [470, 2008], 'angioplasty': [471], 'peripheral': [474, 534, 1640, 2714, 2820], 'arteries.20See': [475], 'article': [476, 879], 'page': [478], '2182The': [479], 'second': [480], 'major': [481], 'group': [482], 'belong': [486], 'immunoglobulin': [489, 2408], 'supergene': [490], 'family,': [491], '2': [493, 3631], 'members': [494], 'warrant': [495], 'attention.': [496], 'intercellular': [498, 1607, 2218, 2435, 2513], 'molecule-1': [500, 571, 1466, 1609, 2089, 2135, 2164, 2220, 2440, 2515], '(sICAM-1)': [501, 2986], 'likely': [504, 1292], 'many': [507, 526, 644, 1056], 'cells,': [508, 610], 'leukocytes.': [513], 'Also': [514], 'influenced': [515], 'inflammatory': [517, 1138, 1296, 1386], 'cytokines': [518], 'both': [531, 966], 'coronary': [532, 697, 709, 904, 1917, 2290, 2322], 'artery': [535, 698, 710, 816, 905, 1479, 1641, 2291, 3421], 'disease.21': [536], 'sICAM-1': [542, 587, 870, 915, 964], 'men': [545, 707], 'women': [547], 'events,6,22': [550], 'association': [552], 'weaker': [554], 'when': [555, 1318], 'there': [556, 667], 'background': [559], 'existing': [561, 903], 'atherosclerosis.7': [562], 'Conversely,': [563, 700], 'despite': [564, 622, 823], 'reports': [565, 646], 'vascular': [568, 1162, 1344, 1517, 1585, 2086, 2132, 2161, 2191, 2257, 2438, 2715], '(sVCAM-1)': [572], 'conditions,17,18,21,23,24': [576], 'outcome.7,25Increased': [584], 'sVCAM-1': [589], 'often': [591, 664], 'taken': [592], 'imply': [594, 1307], 'and/or': [596], 'stimulation': [597], 'endothelium,': [600], 'smooth': [608, 2192, 2258], 'muscle': [609, 2193, 2259], 'leukocytes,': [611], 'tumor': [613], 'suggests': [615], 'some': [616, 763, 890], 'caution': [617], 'necessary.26–28': [620], 'caveats,': [624], 'variety': [632, 1283], 'inflammatory,': [635], 'widely': [640, 1075], 'reported,': [641], 'individual': [645], 'they': [647], 'predicting': [651, 1149], 'clinical': [652, 729, 1243, 1264, 1285, 1301, 2852, 3579], 'outcome,': [653, 3580], 'precise': [656], 'mechanisms': [657, 786, 1179], 'consequences': [659], 'unclear.': [665], 'also': [669, 741, 1084], 'possible': [670, 1058], 'conflict:': [671], 'Blankenberg': [672, 2267], 'et': [673, 702, 808, 882, 1510], 'al29': [674], 'baseline': [677], 'sVCAM-1,': [678], 'sICAM-1,': [679, 1050], 'sE-selectin': [681], 'were': [682, 872, 965, 971], 'all': [683], 'significantly': [684], 'related': [685, 769, 1066], 'future': [687, 875, 1161, 1613, 1861, 2519], 'death': [688, 2286, 2565], 'from': [689, 1262, 1314, 2526, 2686], 'causes': [691], 'among': [692], '1246': [693], 'patients': [694, 960, 1153, 1920, 2003, 2288, 2567, 3100, 3575], 'documented': [696], 'disease.': [699, 803, 1944, 1971, 2292, 2657, 2716, 2822], 'Malik': [701, 2298], 'al,30': [703], 'up': [705], '643': [706], '1278': [713], 'controls,': [714], 'measurement': [717], 'molecules,': [721], 'while': [722, 1289], 'having': [723], 'univariate': [724], 'predictive': [725, 873], 'value,': [726], 'had': [727], 'limited': [728], 'utility': [730], 'multivariate': [732], 'models,': [733], 'which': [734, 1135, 1150], 'accounted': [735], 'established': [737, 948], 'risk': [738, 953, 975, 1007, 1089, 1157, 1189, 1859, 2517, 2559, 2653, 2711, 2736, 2776, 2799], 'factors.Stroke': [739], 'case': [743], 'point.': [745, 943], 'Not': [746], 'surprisingly,': [747], 'numerous': [748], 'groups': [749], 'markers': [756, 1117, 1139, 2046], 'short': [759], 'period': [760], 'stroke,31–34': [762], 'proposing': [764], 'profound': [772], 'alterations': [773], 'metabolic': [776], 'homeostasis': [777], 'patients.': [780], 'Therefore,': [781], 'pursuit': [783], 'leading': [787, 1180], 'makers': [793], 'additional': [796], 'clues': [797], 'this': [802, 805, 885, 894, 1254, 1354], 'In': [804], 'respect,': [806], 'Rohde': [807, 2454], 'al35': [809], 'strong': [812], 'correlation': [813], 'carotid': [815, 2386, 2483], 'intima-media': [817], 'thickness': [818], 'sICAM-1.': [821], 'interesting': [825], 'short-term': [826], 'cross-sectional': [828], 'reports,': [829], 'what': [830, 1110, 1121, 1338], 'would': [831, 838], 'most': [833, 1074, 1142], 'valuable': [834], 'clinician': [837], 'know': [841], 'whether': [842], 'outcome': [848, 3480], 'long-term': [851], 'study.': [852, 2786], 'To': [853, 1206], 'date,': [854, 1207], 'few': [855, 1208], 'prospective': [856, 2326, 2347], 'data': [857, 1304], 'available': [860], 'cerebrovascular': [862, 1132, 3270, 3357, 3448], 'Health': [868], 'Study,': [869], 'thromboembolic': [876], 'stroke': [877, 1009, 2383, 2779], 'events.22The': [878], 'Tanne': [881, 2494], 'al36': [883], 'current': [886], 'issue': [887], 'ofStroke': [888], 'goes': [889], 'way': [891], 'answer': [893, 1165, 1194], 'question.': [895], 'Their': [896], 'nested': [897, 2523], 'case-control': [898, 2524], 'study': [899, 2327, 2348, 2525, 2532], 'subjects': [901], 'smoking,': [910, 1021, 1072, 1652], 'fibrinogen,': [912, 1213, 1323, 2809], 'serum': [914, 2685], '(see': [916, 982, 1043], 'Table': [917, 1044], '1': [918, 1422], 'article)': [921], '134': [924, 935], 'cases': [925], 'who,': [926], 'after': [927, 1014, 1472, 3331], '8.2': [928], 'years,': [929], 'suffered': [930], 'stroke,': [932, 977, 3103, 3333, 3385, 3484, 3542], 'compared': [933, 1212, 1319], 'controls': [936], 'who': [937], 'did': [938], 'an': [941, 979, 1087, 1333, 3476, 3507], 'end': [942], 'It': [944, 1233], 'long': [946, 1258], 'fibrinogen': [950, 962, 1030, 1053, 1070], 'factor': [954, 2444], 'disease,37': [957], 'those': [959, 1174, 1221, 1359], 'whose': [961], 'highest': [969, 974, 1156], 'tertile': [970], 'suggesting': [978], 'additive': [980], 'effect': [981, 2886], 'Figure': [983], '2).': [984], 'smoking': [986, 993, 1002, 2588, 2645], 'diabetes': [988, 1526, 1814, 2622], 'can': [989, 994, 1272], 'influence': [990], 'sICAM-1,38,39': [991], 'increase': [995], 'fibrinogen.40': [996], 'After': [997, 3612], 'multivariable': [998], 'adjustment': [999, 1015], 'either': [1001], 'lipids,': [1004], 'relative': [1006], 'became': [1010, 1040], 'more': [1011, 1312], 'significant.': [1012], 'combination': [1018], 'hypertension,': [1022], 'previous': [1024], 'myocardial': [1025, 1439, 1614, 1832, 2561], 'infarction,': [1026], 'without': [1029], 'white': [1032, 1994], 'blood': [1033, 1995, 3354, 3503], 'count,': [1035], 'previously': [1037], 'significant': [1038, 1042], 'trends': [1039], '2).A': [1045], 'further': [1046], 'mechanism': [1047], 'linking': [1049], 'thrombosis,': [1051, 1182], '(and,': [1054], 'indeed,': [1055], 'other': [1057, 2045, 2647], 'markers)': [1062], 'inflammation,': [1064], 'possibly': [1065], 'smoking.16,41,42': [1068], 'Like': [1069], 'accepted': [1076], 'marker': [1077, 1758, 1836, 3478], 'inflammation': [1079, 1119, 1345, 2048, 3301], '(C-reactive': [1080], 'protein': [1081, 1711, 2043, 2682, 2709, 2774, 2848, 3414], '[CRP])': [1082], 'associated': [1085, 3022], 'disease,43': [1095], 'stroke.22,44,45': [1097], 'Two': [1098], 'questions,': [1099], 'one': [1100, 1103], 'pathophysiologic': [1101], 'clinical,': [1104], 'therefore': [1106, 1331], 'immediately': [1107], 'relevant.': [1108], 'First,': [1109], 'interrelationships': [1113], 'different': [1115], 'tell': [1124], 'us': [1125], 'about': [1126], 'disease?': [1133], 'Second,': [1134], 'offer': [1144], 'clinically': [1145], 'terms': [1147], 'suffering': [1159], 'event?': [1163], 'The': [1164, 1193, 1733, 1993, 3032, 3377, 3443], 'former': [1168], 'will': [1169, 1198], 'seeking': [1175], 'understand': [1177], 'thus': [1184], 'how': [1185], 'minimize': [1187], 'its': [1191], 'occurrence.': [1192], 'latter': [1197], 'eagerly': [1200], 'awaited': [1201], 'epidemiologists': [1203], 'clinicians.': [1205], 'directly': [1211], 'IL-6,': [1214], 'ICAM,': [1215], 'VCAM,': [1216], 'P-selectin,': [1217], 'CRP,': [1219], 'consistently': [1224], 'CRP': [1226, 1246, 1290, 1309], 'greatest': [1230], 'prognostic': [1231], 'utility.22,46': [1232], 'important': [1235, 1313], 'recognize,': [1237], 'however,': [1238], 'apparent': [1241], 'superior': [1242], 'performance': [1244], 'due': [1248], 'largely': [1249], 'fact': [1252], 'biomarker': [1255, 1297], 'half-life,': [1259], 'stable': [1261], 'chemistry': [1265], 'perspective,': [1266], 'no': [1268], 'circadian': [1269], 'variation,': [1270], 'measured': [1274], 'simple': [1277], 'reproducible': [1278], 'bioassay': [1279], 'wide': [1282], 'outpatient': [1286], 'settings.47': [1287], 'Thus,': [1288], 'choice': [1299], 'purposes,': [1302], 'necessarily': [1311, 1358], 'biologic': [1316], 'perspective': [1317], 'upstream': [1321], 'cytokines,': [1322], 'molecules.': [1328], 'We': [1329], 'must': [1330], 'keep': [1332], 'open': [1334], 'mind': [1335], 'appropriate': [1340], 'pharmacologic': [1341], 'targets': [1342], 'might': [1346], 'future.The': [1350], 'opinions': [1351], 'expressed': [1352], 'editorial': [1355], 'editors': [1362], 'American': [1366], 'Stroke': [1367, 3175, 3236, 3247, 3450, 3635, 3662, 3668, 3701, 3763], 'Association.Dr': [1368], 'listed': [1371], 'co-inventor': [1374], 'patents': [1376], 'filed': [1377], 'Hospital': [1382], 'biomarkers': [1387, 3024, 3267, 3328, 3355], 'disease.FootnotesCorrespondence': [1390], 'Dr': [1392], 'AD': [1393], 'Thrombosis,': [1398], 'Unit,': [1402], 'Dudley': [1412], 'Rd,': [1413], 'Birmingham': [1414], 'B18': [1415], '7QH,': [1416], 'UK.': [1417], 'E-mail': [1418], '[email': [1419], 'protected]': [1420], 'References': [1421], 'Hayward': [1423], 'R,': [1424, 1430, 1509, 1568, 1720, 1870, 1988, 2116, 2124, 2206, 2396, 3406, 3593, 3685, 3742], 'Campbell': [1425], 'B,': [1426, 1598, 1667, 1770, 1793, 2608, 2610, 3220, 3744], 'Shin': [1427], 'YK,': [1428], 'Scalia': [1429], 'Lefer': [1431], 'AM.': [1432], 'Recombinant': [1433], 'ligand-1': 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'23:4,': [3428], '(785-790),': [3429], '1-Apr-2009.': [3433], 'Chapter': [3441, 3630], '51': [3442], 'interactions': [3444], 'Part': [3451], 'III:': [3452], 'Investigation': [3453], 'Management,': [3455], '10.1016/S0072-9752(08)94051-3,': [3456], '(1039-1057),': [3457], 'Waje-Andreassen': [3459], 'Krakenes': [3461], 'Ulvestad': [3463], 'Thomassen': [3465], 'Myhr': [3467], 'Aarseth': [3469], 'Vedeler': [3472], 'C': [3473], '(2005)': [3474, 3501], 'IL-6:': [3475], 'early': [3477], 'Acta': [3485], 'Neurologica': [3486], 'Scandinavica,': [3487], '10.1111/j.1600-0404.2005.00416.x,': [3488], '(360-365),': [3490], '1-Jun-2005.': [3494], 'Napoli': [3496], 'Papa': [3499], 'F': [3500], 'pressure,': [3504], 'opportunity': [3508], 'target': [3510], 'primary': [3511], 'prevention?,': [3512], 'Hypertension': [3514], 'Reports,': [3515], '10.1007/s11906-005-0054-8,': [3516], '7:1,': [3517], '(44-51),': [3518], '1-Jan-2005.': [3522], 'PEDERSEN': [3523], 'WAJE-ANDREASSEN': [3525], 'VEDELER': [3527], 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