Publication Information

{'id': 'https://openalex.org/W2121419977', 'doi': 'https://doi.org/10.1158/0008-5472.can-10-3978', 'title': 'Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations', 'display_name': 'Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations', 'publication_year': 2011, 'publication_date': '2011-04-30', 'ids': {'openalex': 'https://openalex.org/W2121419977', 'doi': 'https://doi.org/10.1158/0008-5472.can-10-3978', 'mag': '2121419977', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21531761', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3117125'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-10-3978', 'pdf_url': 'https://aacrjournals.org/cancerres/article-pdf/71/12/4172/2655352/4172.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aacrjournals.org/cancerres/article-pdf/71/12/4172/2655352/4172.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077597600', 'display_name': 'Takuya Osada', 'orcid': 'https://orcid.org/0000-0003-1424-5001'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Takuya Osada', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001541342', 'display_name': 'Minyong Chen', 'orcid': 'https://orcid.org/0000-0001-5910-6684'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Minyong Chen', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100772614', 'display_name': 'Yao Xiao', 'orcid': 'https://orcid.org/0000-0003-1246-7065'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiao Yi Yang', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090604007', 'display_name': 'Ivan Spasojević', 'orcid': 'https://orcid.org/0000-0001-9890-6246'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ivan Spasojevic', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060904459', 'display_name': 'Jeffrey VanDeusen', 'orcid': 'https://orcid.org/0000-0002-4171-5649'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey B. Vandeusen', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023821870', 'display_name': 'David S. Hsu', 'orcid': 'https://orcid.org/0000-0002-8149-7180'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Hsu', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111960312', 'display_name': 'Bryan M. Clary', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bryan M. Clary', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104348991', 'display_name': 'Timothy M. Clay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy M. Clay', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100780046', 'display_name': 'Wei Chen', 'orcid': 'https://orcid.org/0000-0002-9934-4000'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Chen', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074731037', 'display_name': 'Michael A. Morse', 'orcid': 'https://orcid.org/0000-0002-5725-4533'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael A. Morse', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012804507', 'display_name': 'H. Kim Lyerly', 'orcid': 'https://orcid.org/0000-0002-0063-4770'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'H. Kim Lyerly', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Department of Surgery, 2Department of Medicine, Division of Gastroenterology, 3Department of Medicine, Clinical Pharmacology Lab, 4Department of Medicine, Division of Medical Oncology, and 5Department of Immunology, Duke University Medical Center, Durham, North Carolina", 'institution_ids': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210126298']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5012804507'], 'corresponding_institution_ids': ['https://openalex.org/I4210126298'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.313, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 253, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '71', 'issue': '12', 'first_page': '4172', 'last_page': '4182'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/niclosamide', 'display_name': 'Niclosamide', 'score': 0.9620935}, {'id': 'https://openalex.org/keywords/adenomatous-polyposis-coli', 'display_name': 'Adenomatous polyposis coli', 'score': 0.66230434}, {'id': 'https://openalex.org/keywords/dishevelled', 'display_name': 'Dishevelled', 'score': 0.5258261}, {'id': 'https://openalex.org/keywords/beta-catenin', 'display_name': 'Beta-catenin', 'score': 0.4469284}], 'concepts': [{'id': 'https://openalex.org/C2776306103', 'wikidata': 'https://www.wikidata.org/wiki/Q418523', 'display_name': 'Niclosamide', 'level': 2, 'score': 0.9620935}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.92562526}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7017494}, {'id': 'https://openalex.org/C2778237340', 'wikidata': 'https://www.wikidata.org/wiki/Q14883378', 'display_name': 'Adenomatous polyposis coli', 'level': 4, 'score': 0.66230434}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.62885153}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.53630173}, {'id': 'https://openalex.org/C2775928862', 'wikidata': 'https://www.wikidata.org/wiki/Q5282208', 'display_name': 'Dishevelled', 'level': 5, 'score': 0.5258261}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.4972985}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.49336782}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.49051255}, {'id': 'https://openalex.org/C2779324961', 'wikidata': 'https://www.wikidata.org/wiki/Q1634046', 'display_name': 'Beta-catenin', 'level': 4, 'score': 0.4469284}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27687097}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26920515}, {'id': 'https://openalex.org/C107300179', 'wikidata': 'https://www.wikidata.org/wiki/Q41797887', 'display_name': 'Frizzled', 'level': 4, 'score': 0.22932917}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.10462734}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000871', 'descriptor_name': 'Anthelmintics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D017491', 'descriptor_name': 'Genes, APC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009534', 'descriptor_name': 'Niclosamide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000871', 'descriptor_name': 'Anthelmintics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000072261', 'descriptor_name': 'Dishevelled Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D009534', 'descriptor_name': 'Niclosamide', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D009534', 'descriptor_name': 'Niclosamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009944', 'descriptor_name': 'Organoplatinum Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009944', 'descriptor_name': 'Organoplatinum Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077150', 'descriptor_name': 'Oxaliplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-10-3978', 'pdf_url': 'https://aacrjournals.org/cancerres/article-pdf/71/12/4172/2655352/4172.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3117125', 'pdf_url': 'https://europepmc.org/articles/pmc3117125?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117125', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22388664', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_from_Antihelminth_Compound_Niclosamide_Downregulates_Wnt_Signaling_and_Elicits_Antitumor_Responses_in_Tumors_with_Activating_APC_Mutations/22388664/1/files/39834153.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21531761', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-10-3978', 'pdf_url': 'https://aacrjournals.org/cancerres/article-pdf/71/12/4172/2655352/4172.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1495670272', 'https://openalex.org/W1935863539', 'https://openalex.org/W1967803088', 'https://openalex.org/W1968064237', 'https://openalex.org/W1969534054', 'https://openalex.org/W1969892000', 'https://openalex.org/W1972747946', 'https://openalex.org/W1986724654', 'https://openalex.org/W1990633837', 'https://openalex.org/W2001943317', 'https://openalex.org/W2009684443', 'https://openalex.org/W2010339083', 'https://openalex.org/W2012336255', 'https://openalex.org/W2026569756', 'https://openalex.org/W2035192365', 'https://openalex.org/W2035809306', 'https://openalex.org/W2039435520', 'https://openalex.org/W2041856923', 'https://openalex.org/W2048229668', 'https://openalex.org/W2059857664', 'https://openalex.org/W2068017239', 'https://openalex.org/W2072573412', 'https://openalex.org/W2073683774', 'https://openalex.org/W2097689792', 'https://openalex.org/W2110345152', 'https://openalex.org/W2125070068', 'https://openalex.org/W2131729719', 'https://openalex.org/W2138544728', 'https://openalex.org/W2144030492', 'https://openalex.org/W2150032631', 'https://openalex.org/W2167638513', 'https://openalex.org/W2184295157', 'https://openalex.org/W2399410610'], 'related_works': ['https://openalex.org/W4206653363', 'https://openalex.org/W3037544169', 'https://openalex.org/W2363071306', 'https://openalex.org/W2157198584', 'https://openalex.org/W2155308439', 'https://openalex.org/W2097268699', 'https://openalex.org/W2005440429', 'https://openalex.org/W2001943261', 'https://openalex.org/W1987109815', 'https://openalex.org/W1975306683'], 'abstract_inverted_index': {'Wnt/β-catenin': [0, 49, 73], 'pathway': [1, 50, 74], 'activation': [2], 'caused': [3], 'by': [4, 96], 'adenomatous': [5], 'polyposis': [6], 'coli': [7], '(APC)': [8], 'mutations': [9, 104], 'occurs': [10], 'in': [11, 34, 51, 62, 86, 105, 120], 'approximately': [12], '80%': [13], 'of': [14, 25, 65, 99, 103, 110, 163], 'sporadic': [15], 'colorectal': [16], 'cancers': [17], '(CRC).': [18], 'The': [19], 'antihelminth': [20], 'compound': [21], 'niclosamide': [22, 45, 71, 134, 159], 'downregulates': [23], 'components': [24], 'the': [26, 48, 63, 161], 'Wnt': [27], 'pathway,': [28], 'specifically': [29], 'Dishevelled-2': [30], '(Dvl2)': [31], 'expression,': [32], 'resulting': [33], 'diminished': [35], 'downstream': [36, 79], 'β-catenin': [37, 80], 'signaling.': [38], 'In': [39, 107, 125], 'this': [40], 'study,': [41], 'we': [42], 'determined': [43], 'whether': [44, 55], 'could': [46], 'inhibit': [47], 'human': [52, 87, 129], 'CRCs': [53], 'and': [54, 82, 92, 140, 147], 'its': [56], 'inhibition': [57, 109], 'might': [58], 'elicit': [59], 'antitumor': [60], 'effects': [61, 85, 119], 'presence': [64], 'APC': [66], 'mutations.': [67], 'We': [68], 'found': [69], 'that': [70], 'inhibited': [72], 'activation,': [75], 'downregulated': [76], 'Dvl2,': [77], 'decreased': [78], 'signaling,': [81], 'exerted': [83], 'antiproliferative': [84, 118], 'colon': [88], 'cancer': [89], 'cell': [90], 'lines': [91], 'CRC': [93, 122, 130], 'cells': [94], 'isolated': [95], 'surgical': [97], 'resection': [98], 'metastatic': [100], 'disease,': [101], 'regardless': [102], 'APC.': [106], 'contrast,': [108], 'NF-κB': [111], 'or': [112], 'mTOR': [113], 'did': [114], 'not': [115], 'exert': [116], 'similar': [117], 'these': [121], 'model': [123], 'systems.': [124], 'mice': [126], 'implanted': [127], 'with': [128, 144], 'xenografts,': [131], 'orally': [132], 'administered': [133], 'was': [135], 'well': [136], 'tolerated,': [137], 'achieved': [138], 'plasma': [139], 'tumor': [141, 150], 'levels': [142], 'associated': [143], 'biologic': [145], 'activity,': [146], 'led': [148], 'to': [149, 157], 'control.': [151], 'Our': [152], 'findings': [153], 'support': [154], 'clinical': [155], 'explorations': [156], 'reposition': [158], 'for': [160], 'treatment': [162], 'CRC.': [164]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2121419977', 'counts_by_year': [{'year': 2024, 'cited_by_count': 20}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 32}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-23T11:32:40.674072', 'created_date': '2016-06-24'}