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'down-regulation': [66, 140], '30%': [71], 'occurred': [75], '48': [76], 'h': [77, 175], 'after': [78, 176], 'addition.': [80], 'T47D': [81, 144], 'showed': [85], 'similar': [87], 'with': [89, 187], 'mibolerone,': [90], 'while': [91, 146], 'normal': [95], 'skin': [96], 'fibroblasts': [97], 'did': [98, 184], 'not': [99, 147, 185], 'respond': [100], 'treatment.': [103, 178], 'As': [104], 'shown': [105], 'nuclease': [107], 'S1': [108], 'analysis,': [109], 'transcripts': [111], 'initiate': [112], 'at': [113], 'three': [114], 'principal': [115], 'start': [116], 'sites,': [117], 'all': [118], 'which': [120], 'are': [121], 'equally': [122], 'sensitive': [123], 'androgen.': [125], 'Steroidal': [126], 'as': [127, 129], 'well': [128], 'nonsteroidal': [130], 'were': [132], 'capable': [133], 'partially': [135], 'antagonizing': [136], 'androgen-mediated': [137], 'cells,': [145], 'exerting': [148], 'significant': [150], 'when': [152], 'administered': [153], 'alone.': [154], 'While': [155], 'stability': [158], 'increased': [160], 'hormone,': [162], 'nuclear': [163], 'run-on': [164], '4-fold': [168], 'reduction': [169], 'gene': [172, 261], 'transcription': [173], '96': [174], 'Although': [179], 'decreased': [180], 'coincide': [186], 'parallel': [189], 'AR': [192, 246], 'protein': [193], 'levels,': [194, 233], 'androgen-inducible': [197], 'reporter': [198], 'constructs': [199], 'demonstrated': [200], 'that': [201, 222], 'prolonged': [202, 223], 'administration': [204], 'results': [207, 220], 'progressively': [210], 'impaired': [211], 'sensitivity': [212], 'intracellular': [215], 'response': [217], 'mechanism.': [218], 'These': [219], 'show': [221], 'exposure': [225], 'leads,': [226], 'besides': [227], 'its': [228], 'functional': [235], 'inactivation': [236], 'AR.': [239], 'Thus,': [240], 'vivo,': [242], 'posttranslational': [243], 'activity': [247], 'appears': [248], 'be': [250], 'novel': [252], 'negative': [255], 'autoregulation': [256], 'effects': [259], 'expression.': 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