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'autoimmune': [720], 'diseases),': [721], 'variants': [723, 1121, 1143], 'MHC': [726], 'imputed.': [728], 'That': [729], 'important': [730, 997, 1131], 'conclusions': [732], 'drawn': [735], 'from': [736, 881], 'such': [737, 1157, 1192], 'powered': [740, 1023], 'might': [742], 'expected;': [744], 'unfortunately,': [745], 'this': [746, 817], 'not': [748, 767], 'case.': [750], 'findings': [753], 'were,': [754], 'first,': [755], 'previously': [758], 'proposed': [759], 'relation': [760, 1280], 'between': [761, 838, 1186], 'true': [769], 'one;': [770], 'rather,': [771], 'it': [772, 1127, 1169], 'driven': [774], 'by': [775, 799, 808, 1110, 1469, 1482], 'young': [779], 'location;': [785], 'second,': [787], '(L2)': [792], 'better': [797, 1467], 'predicted': [798], 'HLA': [801], 'alleles': [803, 811], 'To': [815], 'investigate': [816], 'finding': [818], 'researchers': [821], 'resorted': [822], 'predictive': [824, 955], 'models': [825], 'showed': [830], 'genetically': [836, 879, 1503], 'intermediate': [837], 'colitis.': [844], 'conclude': [873], 'distinct': [880], 'propose': [886], 'nomenclature': [889], '(however,': [894], 'L3': [895], 'disease—the': [896], 'location—is': [900], 'inexplicably': [901], 'left': [902], 'out).': [903], 'Only': [904], 'three': [905, 1470], '(NOD2,': [908], 'MHC,': [909], '3p21/MST1)': [911], 'achieved': [912], 'significance': [914], 'colleagues': [923], 'study,8Cleynen': [924, 1024], 'but': [950], 'when': [951], 'combined': [952], 'model': [956], 'clinical–demographic': [958], 'factors,': [959, 1055, 1182], 'these': [960], 'unable': [963], 'explain': [965], 'variance.': [967], 'Next': [968], 'NOD2,': [970], 'smoking': [975], 'drivers': [979], 'adult': [984], 'whereas,': [987], 'determinant': [998], 'extent,': [1001], 'albeit': [1002], 'modest': [1004], 'effect.': [1005], 'feeble': [1007], 'tone': [1008], 'our': [1010, 1014], 'criticism': [1011], 'merely': [1012], 'reflects': [1013], 'disappointment': [1015], 'that,': [1016], 'essence,': 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'whole-genome': [1159], 'exome': [1161], 'sequencing': [1162], 'will': [1163], 'perhaps': [1164], 'bring': [1165], 'additional': [1166], 'insight.': [1167], 'Fundamentally,': [1168], 'clear': [1171], 'gene–environment': [1173], 'connections': [1174], 'systematically': [1179, 1340], 'interrogated.': [1180], 'Epigenetic': [1181], 'mediating': [1183], 'genetics': [1187], 'complex': [1189], 'exposures': [1191], 'microbiome,': [1195], 'potentially': [1197], 'provide': [1198], 'clues': [1200], 'pathogenesis': [1203], 'years': [1206], 'come.9Fraga': [1208], 'MF': [1209, 1213, 1303], 'Ballestar': [1210], 'E': [1211], 'Paz': [1212], 'al.Epigenetic': [1215], 'differences': [1216], 'arise': [1217], 'during': [1218], 'lifetime': [1220], 'twins.Proc': [1223], 'Natl': [1224], 'Acad': [1225], 'Sci': [1226], 'USA.': [1227], '102:': [1229], '10604-10609Crossref': [1230], '(2722)': [1233], '10Ventham': [1236], 'NT': [1237], 'Kennedy': [1238], 'NA': [1239], 'Nimmo': [1240], 'ER': [1241], 'Beyond': [1244], 'discovery': [1246], 'emerging': [1252], 'role': [1253], 'epigenetics.Gastroenterology.': [1255], '2013;': [1256], '145:': [1257], '293-308Summary': [1258], '(219)': [1266], 'Importantly,': [1269], 'classic': [1273], 'epidemiological': [1276], 'findings—such': [1277], 'smoking,': [1282], 'macroscopic': [1284], 'distribution': [1285], 'mesenteric': [1290], 'fat': [1291], 'hypertrophy': [1292], 'disease—remain': [1295], 'explained.11Colombel': [1298], 'Watson': [1300], 'AJ': [1301], 'Neurath': [1302], '10': [1305], 'remaining': [1306], 'mysteries': [1307], 'disease.Gut.': [1311], '2008;': [1312], '57:': [1313], '429-433Crossref': [1314], '(57)': [1317], 'highlights': [1324], 'urgent': [1326], 'innovative': [1329], 'thinking': [1330], 'development': [1333], 'research': [1337], 'roadmap': [1338], 'integrates': [1341], 'non-genetic': [1344], 'factors.': [1345], 'JT': [1346], 'consultant': [1351, 1366], 'AbbVie': [1353], 'speaker': [1357, 1429], 'Ferring': [1359], 'Falk.': [1361], 'J-FC': [1362, 1424], 'advisory': [1368], 'board': [1369], 'member': [1370], 'AbbVie,': [1372, 1431], 'AB': [1373], 'Science,': [1374], 'Amgen,': [1375], 'Bristol-Myers': [1376], 'Squibb,': [1377], 'Celltrion,': [1378], 'Danone,': [1379], 'Ferring,': [1380, 1432], 'Genentech,': [1381], 'Giuliani': [1382], 'SpA,': [1383], 'Given': [1384], 'Imaging,': [1385], 'Janssen,': [1386, 1433], 'Immune': [1387], 'Pharmaceuticals,': [1388, 1394, 1412], 'MedImmune,': [1389], 'Merck': [1390, 1434], '&': [1391, 1422, 1435], 'Co,': [1392, 1436], 'Millennium': [1393], 'Neovacs,': [1395], 'Nutrition': [1396, 1437], 'Science': [1397, 1438], 'Partners': [1398, 1439], 'Ltd,': [1399, 1440], 'Pfizer,': [1400], 'Prometheus': [1401], 'Laboratories,': [1402], 'Protagonist,': [1403], 'Receptos,': [1404], 'Sanofi,': [1405], 'Schering-Plough,': [1406], 'Second': [1407], 'Genome,': [1408], 'Shire,': [1409], 'Takeda,': [1410], 'Teva': [1411], 'TiGenix,': [1413], 'UCB': [1414], 'Pharma,': [1415], 'Vertex,': [1416], 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