Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2121089480', 'doi': 'https://doi.org/10.1017/s1461145710001288', 'title': '5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria', 'display_name': '5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria', 'publication_year': 2010, 'publication_date': '2010-11-01', 'ids': {'openalex': 'https://openalex.org/W2121089480', 'doi': 'https://doi.org/10.1017/s1461145710001288', 'mag': '2121089480', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21040618', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3110346'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1017/s1461145710001288', 'pdf_url': 'https://academic.oup.com/ijnp/article-pdf/14/4/479/2170299/14-4-479.pdf', 'source': {'id': 'https://openalex.org/S199972112', 'display_name': 'The International Journal of Neuropsychopharmacology', 'issn_l': '1461-1457', 'issn': ['1461-1457', '1469-5111'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311647', 'host_organization_name': 'University of Oxford', 'host_organization_lineage': ['https://openalex.org/P4310311647'], 'host_organization_lineage_names': ['University of Oxford'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://academic.oup.com/ijnp/article-pdf/14/4/479/2170299/14-4-479.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071038030', 'display_name': 'Diego Andolina', 'orcid': 'https://orcid.org/0000-0002-9143-858X'}, 'institutions': [{'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}, {'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Diego Andolina', 'raw_affiliation_strings': ['Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}, {'raw_affiliation_string': 'Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107141794', 'display_name': 'David Conversi', 'orcid': 'https://orcid.org/0000-0002-3959-0373'}, 'institutions': [{'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}, {'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'David Conversi', 'raw_affiliation_strings': ['Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}, {'raw_affiliation_string': 'Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051277771', 'display_name': 'Simona Cabib', 'orcid': 'https://orcid.org/0000-0001-8781-8603'}, 'institutions': [{'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}, {'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Simona Cabib', 'raw_affiliation_strings': ['Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}, {'raw_affiliation_string': 'Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084663491', 'display_name': 'Antonio Trabalza', 'orcid': 'https://orcid.org/0000-0003-3018-9820'}, 'institutions': [{'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonio Trabalza', 'raw_affiliation_strings': ['Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034771875', 'display_name': 'Rossella Ventura', 'orcid': 'https://orcid.org/0000-0002-7601-8683'}, 'institutions': [{'id': 'https://openalex.org/I26415053', 'display_name': "University of L'Aquila", 'ror': 'https://ror.org/01j9p1r26', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I26415053']}, {'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rossella Ventura', 'raw_affiliation_strings': ["Dipartimento di Scienze e Tecnologie Biomediche, Università dell'Aquila, L'Aquila, Italy", 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': "Dipartimento di Scienze e Tecnologie Biomediche, Università dell'Aquila, L'Aquila, Italy", 'institution_ids': ['https://openalex.org/I26415053']}, {'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021996413', 'display_name': 'Stefano Puglisi‐Allegra', 'orcid': 'https://orcid.org/0000-0002-9433-2000'}, 'institutions': [{'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}, {'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefano Puglisi-Allegra', 'raw_affiliation_strings': ['Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}, {'raw_affiliation_string': 'Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020850981', 'display_name': 'Tiziana Pascucci', 'orcid': 'https://orcid.org/0000-0003-1520-7373'}, 'institutions': [{'id': 'https://openalex.org/I4210142264', 'display_name': 'European Brain Research Institute', 'ror': 'https://ror.org/03ay27p09', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210142264']}, {'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Tiziana Pascucci', 'raw_affiliation_strings': ['Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Santa Lucia Foundation, European Centre for Brain Research CERC, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210142264']}, {'raw_affiliation_string': 'Dipartimento di Psicologia and Centro ‘Daniel Bovet’, ‘Sapienza’ University, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1945, 'currency': 'GBP', 'value_usd': 2385, 'provenance': 'doaj'}, 'apc_paid': {'value': 1945, 'currency': 'GBP', 'value_usd': 2385, 'provenance': 'doaj'}, 'fwci': 1.627, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.840063, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '14', 'issue': '04', 'first_page': '479', 'last_page': '489'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/5-hydroxytryptophan', 'display_name': '5-Hydroxytryptophan', 'score': 0.7538667}, {'id': 'https://openalex.org/keywords/phenylalanine-hydroxylase', 'display_name': 'Phenylalanine hydroxylase', 'score': 0.5883305}, {'id': 'https://openalex.org/keywords/infralimbic-cortex', 'display_name': 'Infralimbic cortex', 'score': 0.529984}], 'concepts': [{'id': 'https://openalex.org/C2779399491', 'wikidata': 'https://www.wikidata.org/wiki/Q238544', 'display_name': '5-Hydroxytryptophan', 'level': 4, 'score': 0.7538667}, {'id': 'https://openalex.org/C2781195155', 'wikidata': 'https://www.wikidata.org/wiki/Q18680', 'display_name': 'Prefrontal cortex', 'level': 3, 'score': 0.70320165}, {'id': 'https://openalex.org/C174884520', 'wikidata': 'https://www.wikidata.org/wiki/Q902079', 'display_name': 'Dendritic spine', 'level': 3, 'score': 0.63448954}, {'id': 'https://openalex.org/C207009774', 'wikidata': 'https://www.wikidata.org/wiki/Q420604', 'display_name': 'Phenylalanine hydroxylase', 'level': 4, 'score': 0.5883305}, {'id': 'https://openalex.org/C2781291010', 'wikidata': 'https://www.wikidata.org/wiki/Q178580', 'display_name': 'Period (music)', 'level': 2, 'score': 0.56627315}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5418236}, {'id': 'https://openalex.org/C2779934784', 'wikidata': 'https://www.wikidata.org/wiki/Q16259058', 'display_name': 'Infralimbic cortex', 'level': 4, 'score': 0.529984}, {'id': 'https://openalex.org/C37000724', 'wikidata': 'https://www.wikidata.org/wiki/Q50430226', 'display_name': 'Serotonergic', 'level': 4, 'score': 0.5122263}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.4478628}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.44385937}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.41099912}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39517683}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.38856685}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27611756}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19544691}, {'id': 'https://openalex.org/C2777431362', 'wikidata': 'https://www.wikidata.org/wiki/Q170545', 'display_name': 'Phenylalanine', 'level': 3, 'score': 0.17702422}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006916', 'descriptor_name': '5-Hydroxytryptophan', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003071', 'descriptor_name': 'Cognition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003423', 'descriptor_name': 'Critical Period, Psychological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D049229', 'descriptor_name': 'Dendritic Spines', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008607', 'descriptor_name': 'Intellectual Disability', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006916', 'descriptor_name': '5-Hydroxytryptophan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D003072', 'descriptor_name': 'Cognition Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049229', 'descriptor_name': 'Dendritic Spines', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D049229', 'descriptor_name': 'Dendritic Spines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008607', 'descriptor_name': 'Intellectual Disability', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008607', 'descriptor_name': 'Intellectual Disability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008607', 'descriptor_name': 'Intellectual Disability', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008817', 'descriptor_name': 'Mice, Mutant Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010651', 'descriptor_name': 'Phenylalanine Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010651', 'descriptor_name': 'Phenylalanine Hydroxylase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D010661', 'descriptor_name': 'Phenylketonurias', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D017397', 'descriptor_name': 'Prefrontal Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1017/s1461145710001288', 'pdf_url': 'https://academic.oup.com/ijnp/article-pdf/14/4/479/2170299/14-4-479.pdf', 'source': {'id': 'https://openalex.org/S199972112', 'display_name': 'The International Journal of Neuropsychopharmacology', 'issn_l': '1461-1457', 'issn': ['1461-1457', '1469-5111'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311647', 'host_organization_name': 'University of Oxford', 'host_organization_lineage': ['https://openalex.org/P4310311647'], 'host_organization_lineage_names': ['University of Oxford'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3110346', 'pdf_url': 'https://europepmc.org/articles/pmc3110346?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110346', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21040618', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1017/s1461145710001288', 'pdf_url': 'https://academic.oup.com/ijnp/article-pdf/14/4/479/2170299/14-4-479.pdf', 'source': {'id': 'https://openalex.org/S199972112', 'display_name': 'The International Journal of Neuropsychopharmacology', 'issn_l': '1461-1457', 'issn': ['1461-1457', '1469-5111'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311647', 'host_organization_name': 'University of Oxford', 'host_organization_lineage': ['https://openalex.org/P4310311647'], 'host_organization_lineage_names': ['University of Oxford'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.68, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W1484645141', 'https://openalex.org/W1500274950', 'https://openalex.org/W1522048223', 'https://openalex.org/W1558637398', 'https://openalex.org/W1571283914', 'https://openalex.org/W1589319164', 'https://openalex.org/W1650245142', 'https://openalex.org/W1713895945', 'https://openalex.org/W1793725714', 'https://openalex.org/W1964879653', 'https://openalex.org/W1968741038', 'https://openalex.org/W1972655969', 'https://openalex.org/W1977964638', 'https://openalex.org/W1978127185', 'https://openalex.org/W1983075534', 'https://openalex.org/W1984854704', 'https://openalex.org/W2014789681', 'https://openalex.org/W2014883692', 'https://openalex.org/W2022425690', 'https://openalex.org/W2024034126', 'https://openalex.org/W2024323646', 'https://openalex.org/W2028496416', 'https://openalex.org/W2031499048', 'https://openalex.org/W2037565912', 'https://openalex.org/W2037888238', 'https://openalex.org/W2039508969', 'https://openalex.org/W2043555322', 'https://openalex.org/W2045283840', 'https://openalex.org/W2047493204', 'https://openalex.org/W2052551104', 'https://openalex.org/W2053711620', 'https://openalex.org/W2054675346', 'https://openalex.org/W2056326536', 'https://openalex.org/W2057422453', 'https://openalex.org/W2058743419', 'https://openalex.org/W2071255650', 'https://openalex.org/W2071962431', 'https://openalex.org/W2073680886', 'https://openalex.org/W2085595657', 'https://openalex.org/W2089743996', 'https://openalex.org/W2100901337', 'https://openalex.org/W2105814835', 'https://openalex.org/W2106267269', 'https://openalex.org/W2110328061', 'https://openalex.org/W2111408945', 'https://openalex.org/W2120181048', 'https://openalex.org/W2124683806', 'https://openalex.org/W2126593074', 'https://openalex.org/W2132820737', 'https://openalex.org/W2136403062', 'https://openalex.org/W2138492455', 'https://openalex.org/W2141167930', 'https://openalex.org/W2142401824', 'https://openalex.org/W2144529104', 'https://openalex.org/W2147276634', 'https://openalex.org/W2148386452', 'https://openalex.org/W2151251384', 'https://openalex.org/W2152769084', 'https://openalex.org/W2158106222', 'https://openalex.org/W2169845675', 'https://openalex.org/W2171096494', 'https://openalex.org/W2777548161', 'https://openalex.org/W2999584823', 'https://openalex.org/W4239803780', 'https://openalex.org/W4248905402', 'https://openalex.org/W4285719527', 'https://openalex.org/W57548255'], 'related_works': ['https://openalex.org/W3023930216', 'https://openalex.org/W2802290580', 'https://openalex.org/W2603422891', 'https://openalex.org/W2416494485', 'https://openalex.org/W2286673904', 'https://openalex.org/W2067075854', 'https://openalex.org/W2055075586', 'https://openalex.org/W2047129629', 'https://openalex.org/W1996838710', 'https://openalex.org/W1985131704'], 'abstract_inverted_index': {'Although': [0], 'phenylketonuria': [1], '(PKU)': [2], 'is': [3, 82], 'the': [4, 12, 26, 47, 60, 65, 77, 99, 104, 165, 169, 184], 'most': [5], 'common': [6], 'genetic': [7, 27], 'cause': [8], 'of': [9, 30, 49, 56, 79, 101, 116, 128, 158, 164, 168, 195], 'mental': [10, 187], 'retardation,': [11], 'cellular': [13], 'mechanisms': [14], 'underlying': [15], 'impaired': [16], 'brain': [17, 41, 91, 126, 196], 'function': [18], 'are': [19, 174], 'still': [20], 'unclear.': [21], 'Using': [22], 'PAHenu2': [23], 'mice': [24, 138], '(ENU2),': [25], 'mouse': [28], 'model': [29], 'PKU,': [31], 'we': [32, 97], 'previously': [33], 'demonstrated': [34], 'that': [35, 186, 202], 'high': [36], 'phenylalanine': [37], 'levels': [38, 127], 'interfere': [39], 'with': [40, 204], 'tryptophan': [42, 80], 'hydroxylase': [43], 'activity': [44], 'by': [45, 119, 152, 177], 'reducing': [46], 'availability': [48, 194], 'serotonin': [50], '(5-hydroxytryptamine,': [51], '5-HT),': [52], 'crucial': [53], 'for': [54, 72], 'maturation': [55, 157, 206], 'neuronal': [57], 'connectivity': [58], 'in': [59, 108, 112, 130, 145, 155, 161, 189], 'prefrontal': [61], 'cortex': [62], '(PFC),': [63], 'around': [64], 'third': [66], 'postnatal': [67, 106], 'week,': [68], 'a': [69, 86, 213], 'critical': [70, 199], 'period': [71, 107], 'cortical': [73, 113, 205], 'maturation.': [74], '5-Hydroxytryptophan': [75], '(5-HTP),': [76], 'product': [78], 'hydroxylation,': [81], 'known': [83], 'to': [84, 89, 209, 218], 'be': [85], 'better': [87], 'treatment': [88, 141], 'increase': [90, 154], '5-HT': [92, 102, 129, 197], 'levels.': [93], 'In': [94, 135], 'this': [95], 'study': [96], 'investigated': [98], 'role': [100], 'during': [103, 198], 'early': [105, 139], 'cognitive': [109, 143], 'disturbances': [110], 'and': [111, 147, 207], 'dendritic': [114], 'alterations': [115], 'PKU': [117, 190, 220], 'subjects': [118], 'restoring': [120], 'temporarily': [121], '(postnatal': [122], 'days': [123], '14–21)': [124], 'physiological': [125], 'ENU2': [131, 137], 'through': [132], '5-HTP': [133, 140, 210], 'treatment.': [134, 178], 'adult': [136], 'reverses': [142], 'deficits': [144, 173], 'spatial': [146], 'object': [148], 'recognition': [149], 'tests': [150], 'accompanied': [151], 'an': [153], 'spine': [156], 'pyramidal': [159], 'neurons': [160], 'layer': [162], 'V': [163], 'prelimbic/infralimbic': [166], 'area': [167], 'PFC,': [170], 'although': [171], 'locomotor': [172], 'not': [175], 'recovered': [176], 'Taken': [179], 'together,': [180], 'our': [181], 'results': [182], 'support': [183], 'hypothesis': [185], 'retardation': [188], 'depends': [191], 'on': [192], 'reduced': [193], 'developmental': [200], 'periods': [201], 'interferes': [203], 'point': [208], 'supplementation': [211], 'as': [212], 'highly': [214], 'promising': [215], 'additional': [216], 'tool': [217], 'heal': [219], 'patients.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2121089480', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-11T18:56:11.075118', 'created_date': '2016-06-24'}