Publication Information

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[144], 'tension,': [148], 'whereas': [149], 'much': [157], 'faster': [158], '(Pedersen': [159], '1999);': [162], 'hence,': [163], 'occurs': [171, 1043], 'at': [172, 489, 948, 1260], 'location': [174, 212], 'rapid': [176, 190, 198], 'equilibration': [177], 'arterial': [179], 'blood.': [180], 'Similar': [181], 'differences': [182, 554], 'found': [184, 368], 'responses': [188, 242, 320, 327, 343, 435, 445, 466, 739, 772, 811, 912], 'bicarbonate': [191], 'administration': [192], '(Whitwam': [193], '1976),': [196], 'changes': [199], '(Cunningham': [202, 350, 396], '1986).': [205, 353], 'These': [206, 354, 770, 931], 'various': [207], 'experiments': [208, 356, 549, 614, 787, 879, 933, 1186], 'support': [209], 'for': [213, 1125, 1316, 1342], 'CO2;': [219], 'hypoxia,': [221, 733, 1002], 'sensitive': [226], 'CO2.': [228, 437], 'Therefore,': [229], 'when': [230], 'increases': [232, 292, 1138], 'isoxic': [234, 318, 380, 442, 491, 809, 988], 'both': [236], 'increase.': [243], 'If': [244, 262, 281], 'components': [250], 'add': [251], 'then': [252, 275, 296], 'linear': [258, 326, 386, 469, 536], 'dependence': [259], '.': [261], 'interacts': [266], 'changing': [272], 'its': [273], 'sensitivity': [274, 992], 'becomes': [279], 'non-linear.': [280, 1017], 'positive,': [285], 'so': [286], 'rising': [289], 'sensitivity,': [295], 'combined': [298, 857], 'will': [300, 1265, 1269], 'curve': [301], 'upwards,': [302], 'vice': [304, 1133], 'versa': [305], 'negative.': [310], 'Nielsen': [311], 'Smith': [313], '(1952)': [314], 'published': [315], 'first': [317], 'dioxide.': [323], 'They': [324], 'showed': [325], 'whose': [328], 'slope': [329], 'increased': [330], 'hypoxia.': [332], 'This': [333, 754], 'finding': [334, 805], 'was': [335, 367, 582, 590, 610, 618, 624, 657, 694, 760, 781, 1016], 'quickly': [336], 'verified': [337], 'others': [339, 362], 'eventually': [341], 'were': [344, 724, 773, 798], 'characterized': [345, 450], 'as': [346, 459, 827, 1031, 1053, 1055, 1095, 1212, 1219], "'Oxford'": [348], 'fan': [349], 'steady-state': [355, 395], 'have': [357, 409, 424, 1197], 'been': [358, 425], 'replicated': [359], 'many': [361, 1190, 1294], 'similar': [365, 613], 'result': [366], 'using': [369, 394, 686, 980], 'rebreathing': [370, 401, 487, 984, 990], '1997).': [374, 406], 'Thus,': [375, 1018, 1135], 'experimental': [376], 'measurements': [377, 475, 530], 'most': [388, 471, 1203], '(Fig.': [390], '1),': [391], 'whether': [392, 961, 1114], 'measured': [393], '1986)': [399], 'methods': [402], 'Most': [407], 'modellers': [408], 'therefore': [410, 784], 'assumed': [411], 'additive': [413, 422, 966, 1198, 1209], 'central–peripheral': [414, 544, 580, 622, 779, 824, 890, 1020], '(e.g.': [416], 'Cheng': [417], 'models': [423], 'used': [426, 561, 673, 695], 'separate': [428, 563, 679], 'elements': [432], 'some': [439, 813, 1014, 1142], 'hypoxic': [443, 755, 771, 989], 'may': [448, 821, 1037, 1223, 1248], 'be': [449, 516, 546, 642, 715, 1026, 1147, 1249, 1270, 1299, 1336], 'parabolic': [453, 808], 'fit,': [454], 'indicating': [455, 521], 'positive': [457], 'interaction,': [458, 524, 825], 'discussed': [460], 'Duffin': [462, 485, 496, 982], '(2010);': [463], 'nevertheless': [464], 'such': [465, 826, 962], 'usually': [468], 'individuals.': [472], 'Breath-by': [473], 'breath': [474], 'ventilation,': [477], 'tidal': [478, 526], 'volume': [479, 527], 'frequency': [481, 529], 'obtained': [482], 'during': [483, 732, 746, 757, 767, 987], 'modified': [486, 983], 'test': [488], '=': [492], '40': [493], 'mmHg': [494], 'from': [495, 839, 1184], '(2000).': [499], 'T1': [500], 'recruitment': [504, 709], 'T2': [507], 'patterning': [509], 'threshold.': [510], 'Although': [511], 'might': [515, 1025], 'fitted': [517], 'parabola': [520], 'hyperadditive': [523], 'division': [533], 'into': [534], 'two': [535, 722], 'segments': [537], 'appropriate': [539], 'How': [540], 'else': [541], 'could': [542, 714, 946, 1146, 1297], 'tested?': [547], 'Human': [548], 'often': [551], 'non-invasive.': [552], 'Consequently,': [553], 'chemoreflex': [556, 638, 1058, 1081], 'times': [558], 'frequently': [560], 'components.': [568], 'An': [569], 'early': [570, 840], 'experiment': [571], 'sort': [574], 'Robbins': [576], '(1988)': [577], 'concluded': [578, 599, 619, 1069], 'more': [583], 'than': [584, 1208, 1332], 'additive.': [585, 782], 'However,': [586], 'same': [588], 'protocol': [589], 'repeated': [591], 'St': [593], 'Croix': [594], '(1996),': [597], 'who': [598], 'four': [602], 'five': [605], 'subjects': [606], 'studied': [607], 'no': [608, 1303], 'evident.': [611], 'involving': [615], 'exercise': [616], 'absent': [625, 750], '(Clement': [626], '1992)': [629], 'because': [630, 653], 'dynamics': [632], 'pathways': [639], 'appeared': [640], 'largely': [643], 'each': [646], 'other': [647, 819], '(Macfarlane': [648], 'Cunningham,': [650], '1992),': [651], 'hypoxic–CO2': [655], 'mediated': [658], 'solely': [659], '(Yang': [664], 'Khoo,': [666], '1994).': [667], 'Recently': [668], 'Cui': [669], '(2011)': [672, 1091], 'different': [675, 775], 'temporal': [676], 'sequence': [677], 'responses.': [683, 1040], 'Instead': [684], 'period': [688], 'sustained': [690, 699], 'hypercapnia,': [692], 'hyperventilation': [693, 719], 'produce': [697], 'hypocapnia.': [701], 'With': [702], 'eliminated': [716], 'altogether.': [717], 'After': [718], 'one': [720], 'stimuli': [723], 'used:': [725], 'normoxia.': [735], 'The': [736, 1284, 1311], 'difference': [737], 'yielded': [740], 'low': [748], 'drive.': [753], 'hypocapnia': [759], 'compared': [761], 'hypercapnia.': [769], '10': [777], 'subjects;': [778], 'It': [783], 'appears': [785], 'detect': [791], 'modulation': [794], 'chemoreception': [797], 'unable': [799], 'do': [801], 'so.': [802], 'Nevertheless,': [803, 974, 1110], 'possible': [807], '(Duffin,': [815], 'suggests': [817], 'factors': [820, 1222], 'long-term': [828, 859, 884, 919, 944, 1008, 1035, 1161], 'facilitation': [829, 885, 920, 945, 1036, 1077, 1115, 1162], 'which': [830, 1261], 'enhances': [831], 'sinus': [833], 'phrenic': [835], 'nerve': [836], 'activities.': [837], 'Findings': [838], 'work': [841], 'cats': [843], '(Eldridge': [844], '1981)': [847], 'suggested': [848], 'chemoreflexes,': [856], 'facilitation,': [860], 'negative;': [862], 'possibly': [863], 'consequence': [865, 1033, 1149, 1214], 'saturation': [867], 'inter-neuronal': [870], 'pool': [871], 'receiving': [872], 'convergence': [874], 'these': [876, 1023], 'signals.': [877], 'Indeed,': [878], 'rats': [881, 905], 'without': [883], 'also': [886], 'negative': [889], '(Day': [892], 'Wilson,': [894], '2009).': [895], 'But': [896, 960], 'contrast': [898], "Eldridge's": [900], 'findings,': [901], 'recent': [902], 'studies': [903, 1296], 'chemosensitivity': [909], 'hypercapnia': [914, 1045], 'enhanced': [922, 997], 'multiplicative': [925, 968, 1029, 1151], 'manner': [926], '(Molkov': [927], '2011).': [930], 'animal': [932], 'number': [950], 'sites': [952], '(Guyenet': [956], 'Mulkey,': [958], '2010).': [959], 'interactions': [963, 1030, 1152], 'negative,': [965], 'requires': [971], 'additional': [972], 'investigation.': [973], 'Mateika': [975], '(2004)': [978], 'showed,': [979], 'technique,': [985], 'after': [998, 1085, 1255], 'exposure': [999], 'intermittent': [1001], 'known': [1005], 'initiate': [1007], 'facilitation.': [1009], 'Moreover,': [1010], 'under': [1022, 1189], 'conditions': [1024], 'multiplicative.': [1027], 'Such': [1028], 'involve': [1038], 'sympathetic': [1039, 1108, 1128, 1168], 'Sympathetic': [1041], 'excitation': [1042], '(Pitsikoulis': [1049], '2008)': [1052], 'well': [1054], 'contribution': [1059], '(Shoemaker': [1060], '2002).': [1063], 'Furthermore,': [1064], 'Dahan': [1065], '(2007)': [1068], 'exert': [1074], 'tonic': [1076], 'lost': [1084], 'resection.': [1086], 'Lastly,': [1087], 'Battisti-Charbonney': [1088], 'recently': [1092], 'observed': [1093], 'exceeded': [1098], 'threshold,': [1100], 'blood': [1101], 'increased;': [1103], 'probably': [1104], 'due': [1105, 1288], 'activation.': [1109], 'remains': [1112], 'unclear': [1113], 'responsible': [1124, 1315], 'enhancement': [1126], 'nervous': [1129], 'system': [1130], 'activity': [1131], 'versa.': [1134], 'non-linear': [1137], 'mentioned': [1144], 'earlier': [1145], 'induced': [1159], 'directly': [1163], 'indirectly': [1165], 'via': [1166], 'response.': [1169], 'Further': [1170], 'experimentation': [1171], 'needed': [1173], 'explore': [1175], 'possibility.': [1177], 'We': [1178], 'argue': [1179], 'that,': [1180], 'taken': [1181], 'altogether,': [1182], 'evidence': [1183], 'human': [1185], 'shows': [1187], 'circumstances': [1191, 1216], 'chemoreflexes': [1196], 'effects': [1199], 'individuals,': [1204], 'anything': [1206], 'greater': [1207], 'occurring': [1210], 'only': [1211], 'where': [1217], 'other,': [1218], 'yet': [1220], 'unknown,': [1221], 'apply.': [1224], 'Readers': [1225], 'invited': [1227, 1271], 'give': [1229], 'their': [1230], 'views': 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