Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2120706333', 'doi': 'https://doi.org/10.1128/aac.47.2.529-532.2003', 'title': 'Activity of Tigecycline (GAR-936), a Novel Glycylcycline, against Enterococci in the Mouse Peritonitis Model', 'display_name': 'Activity of Tigecycline (GAR-936), a Novel Glycylcycline, against Enterococci in the Mouse Peritonitis Model', 'publication_year': 2003, 'publication_date': '2003-01-23', 'ids': {'openalex': 'https://openalex.org/W2120706333', 'doi': 'https://doi.org/10.1128/aac.47.2.529-532.2003', 'mag': '2120706333', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12543654', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/151755'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.47.2.529-532.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/aac.47.2.529-532.2003', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040562230', 'display_name': 'Esteban C. Nannini', 'orcid': 'https://orcid.org/0000-0002-8472-7965'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Esteban C. Nannini', 'raw_affiliation_strings': ['Center for the Study of Emerging and Re-Emerging Pathogens', 'Division of Infectious Diseases, Department of Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Center for the Study of Emerging and Re-Emerging Pathogens', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Infectious Diseases, Department of Internal Medicine', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018890161', 'display_name': 'Suresh R. Pai', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Suresh R. Pai', 'raw_affiliation_strings': ['Center for the Study of Emerging and Re-Emerging Pathogens', 'Division of Infectious Diseases, Department of Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Division of Infectious Diseases, Department of Internal Medicine', 'institution_ids': []}, {'raw_affiliation_string': 'Center for the Study of Emerging and Re-Emerging Pathogens', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087237131', 'display_name': 'Kavindra V. Singh', 'orcid': 'https://orcid.org/0000-0003-3005-3982'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kavindra V. Singh', 'raw_affiliation_strings': ['Center for the Study of Emerging and Re-Emerging Pathogens', 'Division of Infectious Diseases, Department of Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Center for the Study of Emerging and Re-Emerging Pathogens', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Infectious Diseases, Department of Internal Medicine', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068293016', 'display_name': 'Barbara E. Murray', 'orcid': 'https://orcid.org/0000-0003-4461-6870'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Barbara E. Murray', 'raw_affiliation_strings': ['Center for the Study of Emerging and Re-Emerging Pathogens', 'Department of Microbiology and Molecular Genetics, The University of Texas Medical School, Houston, Texas', 'Division of Infectious Diseases, Department of Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Center for the Study of Emerging and Re-Emerging Pathogens', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Infectious Diseases, Department of Internal Medicine', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Microbiology and Molecular Genetics, The University of Texas Medical School, Houston, Texas', 'institution_ids': ['https://openalex.org/I86519309']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5068293016'], 'corresponding_institution_ids': ['https://openalex.org/I86519309'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.885, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.704092, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '47', 'issue': '2', 'first_page': '529', 'last_page': '532'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10195', 'display_name': 'Methicillin-Resistant Staphylococcus aureus Infections', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10195', 'display_name': 'Methicillin-Resistant Staphylococcus aureus Infections', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Diagnosis, Treatment, and Epidemiology of Nontuberculous Mycobacterial Diseases', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tigecycline', 'display_name': 'Tigecycline', 'score': 0.95853794}, {'id': 'https://openalex.org/keywords/minocycline', 'display_name': 'Minocycline', 'score': 0.8135774}, {'id': 'https://openalex.org/keywords/enterococcus-faecium', 'display_name': 'Enterococcus faecium', 'score': 0.779034}, {'id': 'https://openalex.org/keywords/enterococcus-faecalis', 'display_name': 'Enterococcus faecalis', 'score': 0.6751704}, {'id': 'https://openalex.org/keywords/vancomycin-resistance', 'display_name': 'Vancomycin Resistance', 'score': 0.464882}], 'concepts': [{'id': 'https://openalex.org/C2777027569', 'wikidata': 'https://www.wikidata.org/wiki/Q420595', 'display_name': 'Tigecycline', 'level': 3, 'score': 0.95853794}, {'id': 'https://openalex.org/C2778275353', 'wikidata': 'https://www.wikidata.org/wiki/Q415336', 'display_name': 'Minocycline', 'level': 3, 'score': 0.8135774}, {'id': 'https://openalex.org/C2777677444', 'wikidata': 'https://www.wikidata.org/wiki/Q140010', 'display_name': 'Enterococcus faecium', 'level': 3, 'score': 0.779034}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.75959325}, {'id': 'https://openalex.org/C2780923616', 'wikidata': 'https://www.wikidata.org/wiki/Q193045', 'display_name': 'Tetracycline', 'level': 3, 'score': 0.7192138}, {'id': 'https://openalex.org/C2780199535', 'wikidata': 'https://www.wikidata.org/wiki/Q223102', 'display_name': 'Peritonitis', 'level': 2, 'score': 0.71451443}, {'id': 'https://openalex.org/C2779895986', 'wikidata': 'https://www.wikidata.org/wiki/Q140014', 'display_name': 'Enterococcus faecalis', 'level': 4, 'score': 0.6751704}, {'id': 'https://openalex.org/C2778980435', 'wikidata': 'https://www.wikidata.org/wiki/Q424027', 'display_name': 'Vancomycin', 'level': 4, 'score': 0.47407237}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.44261298}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.38983303}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33987617}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32817253}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.13491446}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.13371429}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.10194984}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013293', 'descriptor_name': 'Enterococcus faecalis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016984', 'descriptor_name': 'Enterococcus faecium', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010538', 'descriptor_name': 'Peritonitis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013293', 'descriptor_name': 'Enterococcus faecalis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016984', 'descriptor_name': 'Enterococcus faecium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008813', 'descriptor_name': 'Mice, Inbred ICR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010538', 'descriptor_name': 'Peritonitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013754', 'descriptor_name': 'Tetracyclines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013754', 'descriptor_name': 'Tetracyclines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013754', 'descriptor_name': 'Tetracyclines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000078304', 'descriptor_name': 'Tigecycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.47.2.529-532.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc151755', 'pdf_url': 'https://europepmc.org/articles/pmc151755?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151755', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12543654', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.47.2.529-532.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1505626160', 'https://openalex.org/W1581962345', 'https://openalex.org/W1830055331', 'https://openalex.org/W1904634031', 'https://openalex.org/W1909173073', 'https://openalex.org/W1985725647', 'https://openalex.org/W1988711630', 'https://openalex.org/W2031303083', 'https://openalex.org/W2050894506', 'https://openalex.org/W2064773325', 'https://openalex.org/W2088261352', 'https://openalex.org/W2149365938', 'https://openalex.org/W2157559729', 'https://openalex.org/W2157766752', 'https://openalex.org/W2157977215', 'https://openalex.org/W2165499943', 'https://openalex.org/W2168550647', 'https://openalex.org/W2170590083', 'https://openalex.org/W2256756668', 'https://openalex.org/W2398868417', 'https://openalex.org/W2994668721', 'https://openalex.org/W3217730596'], 'related_works': ['https://openalex.org/W4389941515', 'https://openalex.org/W4282914905', 'https://openalex.org/W2942990762', 'https://openalex.org/W2612294841', 'https://openalex.org/W2407757309', 'https://openalex.org/W2356805842', 'https://openalex.org/W2152666008', 'https://openalex.org/W2144489269', 'https://openalex.org/W2102928406', 'https://openalex.org/W1985435370'], 'abstract_inverted_index': {'ABSTRACT': [0], 'A': [1], 'novel': [2], 'glycylcycline': [3], 'agent,': [4], 'tigecycline': [5, 48], '(GAR-936),': [6], 'was': [7], 'evaluated': [8], 'in': [9, 11], 'vivo': [10], 'the': [12, 71, 77, 97], 'mouse': [13], 'model': [14], 'of': [15, 34, 41, 58], 'peritonitis': [16], 'against': [17, 61, 96], 'three': [18], 'Enterococcus': [19, 23], 'faecalis': [20], 'and': [21, 31, 86, 92], 'four': [22], 'faecium': [24], 'isolates': [25, 98], 'with': [26, 67], 'different': [27], 'susceptibilities': [28], 'to': [29], 'vancomycin': [30], 'tetracyclines,': [32], 'all': [33, 62], 'which': [35, 75], 'were': [36, 94], 'inhibited': [37], 'by': [38], '≤0.125': [39], 'μg': [40], 'tigecycline/ml.': [42], 'Using': [43], 'a': [44, 50], 'single': [45], 'subcutaneous': [46], 'dose,': [47, 55], 'displayed': [49], 'protective': [51, 54], 'effect': [52], '(50%': [53], '≤5.7': [56], 'mg/kg': [57], 'body': [59], 'weight)': [60], 'strains': [63], 'tested,': [64], 'including': [65], 'two': [66], 'Tn': [68, 72, 100], '925': [69, 101], '(from': [70], '916': [73], 'family),': [74], 'contains': [76], 'Tet(M)': [78], 'tetracycline': [79, 91], 'resistance': [80], 'determinant,': [81], 'as': [82, 84], 'well': [83], 'VanA': [85], 'VanB': [87], 'strains.': [88], 'As': [89], 'expected,': [90], 'minocycline': [93], 'ineffective': [95], 'carrying': [99], '.': [102]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2120706333', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-09-23T17:09:18.429019', 'created_date': '2016-06-24'}