Efficacies of piperacillin-tazobactam and cefepime in rats with experimental intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae

Name: Work Video:
Duration: 3 min 30 s
C Thauvin-Eliopoulos; M. Tripodi; Robert C. Moellering; George M. Eliopoulos
{'id': 'https://openalex.org/W2120588426', 'doi': 'https://doi.org/10.1128/aac.41.5.1053', 'title': 'Efficacies of piperacillin-tazobactam and cefepime in rats with experimental intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae', 'display_name': 'Efficacies of piperacillin-tazobactam and cefepime in rats with experimental intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae', 'publication_year': 1997, 'publication_date': '1997-05-01', 'ids': {'openalex': 'https://openalex.org/W2120588426', 'doi': 'https://doi.org/10.1128/aac.41.5.1053', 'mag': '2120588426', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9145868', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/163849'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.41.5.1053', 'pdf_url': 'https://aac.asm.org/content/aac/41/5/1053.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aac.asm.org/content/aac/41/5/1053.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058774561', 'display_name': 'C Thauvin-Eliopoulos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092960', 'display_name': 'Deaconess Hospital', 'ror': 'https://ror.org/00h2bj464', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092960']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C Thauvin-Eliopoulos', 'raw_affiliation_strings': ['Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.', 'institution_ids': ['https://openalex.org/I4210092960', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109372966', 'display_name': 'M. Tripodi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210092960', 'display_name': 'Deaconess Hospital', 'ror': 'https://ror.org/00h2bj464', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092960']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M F Tripodi', 'raw_affiliation_strings': ['Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I4210092960']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061176730', 'display_name': 'Robert C. Moellering', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092960', 'display_name': 'Deaconess Hospital', 'ror': 'https://ror.org/00h2bj464', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092960']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R C Moellering', 'raw_affiliation_strings': ['Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.', 'institution_ids': ['https://openalex.org/I4210092960', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112775717', 'display_name': 'George M. Eliopoulos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092960', 'display_name': 'Deaconess Hospital', 'ror': 'https://ror.org/00h2bj464', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092960']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G M Eliopoulos', 'raw_affiliation_strings': ['Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.', 'institution_ids': ['https://openalex.org/I4210092960', 'https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.186, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.810056, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '41', 'issue': '5', 'first_page': '1053', 'last_page': '1057'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12167', 'display_name': 'Bacterial Identification and Susceptibility Testing', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ticarcillin', 'display_name': 'Ticarcillin', 'score': 0.819491}, {'id': 'https://openalex.org/keywords/cefepime', 'display_name': 'Cefepime', 'score': 0.7913122}, {'id': 'https://openalex.org/keywords/tazobactam', 'display_name': 'Tazobactam', 'score': 0.6307176}, {'id': 'https://openalex.org/keywords/beta-lactamase', 'display_name': 'Beta-lactamase', 'score': 0.49824834}, {'id': 'https://openalex.org/keywords/beta-lactamase-inhibitors', 'display_name': 'Beta-Lactamase Inhibitors', 'score': 0.44220904}], 'concepts': [{'id': 'https://openalex.org/C2778719061', 'wikidata': 'https://www.wikidata.org/wiki/Q417968', 'display_name': 'Cefotaxime', 'level': 3, 'score': 0.87116015}, {'id': 'https://openalex.org/C2776083883', 'wikidata': 'https://www.wikidata.org/wiki/Q2601832', 'display_name': 'Ticarcillin', 'level': 5, 'score': 0.819491}, {'id': 'https://openalex.org/C2777050379', 'wikidata': 'https://www.wikidata.org/wiki/Q2552927', 'display_name': 'Cefepime', 'level': 5, 'score': 0.7913122}, {'id': 'https://openalex.org/C2776968632', 'wikidata': 'https://www.wikidata.org/wiki/Q808845', 'display_name': 'Ceftazidime', 'level': 4, 'score': 0.74415773}, {'id': 'https://openalex.org/C2779631663', 'wikidata': 'https://www.wikidata.org/wiki/Q425152', 'display_name': 'Imipenem', 'level': 4, 'score': 0.7236872}, {'id': 'https://openalex.org/C2778193466', 'wikidata': 'https://www.wikidata.org/wiki/Q423787', 'display_name': 'Piperacillin', 'level': 4, 'score': 0.72289264}, {'id': 'https://openalex.org/C2778266534', 'wikidata': 'https://www.wikidata.org/wiki/Q423376', 'display_name': 'Tazobactam', 'level': 5, 'score': 0.6307176}, {'id': 'https://openalex.org/C2777058267', 'wikidata': 'https://www.wikidata.org/wiki/Q132592', 'display_name': 'Klebsiella pneumoniae', 'level': 4, 'score': 0.6207637}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.6096131}, {'id': 'https://openalex.org/C64778159', 'wikidata': 'https://www.wikidata.org/wiki/Q271021', 'display_name': 'Cephalosporin', 'level': 3, 'score': 0.52130455}, {'id': 'https://openalex.org/C2781288988', 'wikidata': 'https://www.wikidata.org/wiki/Q311379', 'display_name': 'Beta-lactamase', 'level': 4, 'score': 0.49824834}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4883718}, {'id': 'https://openalex.org/C2910641391', 'wikidata': 'https://www.wikidata.org/wiki/Q310286', 'display_name': 'Beta-Lactamase Inhibitors', 'level': 3, 'score': 0.44220904}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.43820804}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.39001858}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29813504}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.07276875}, {'id': 'https://openalex.org/C94665300', 'wikidata': 'https://www.wikidata.org/wiki/Q63391344', 'display_name': 'Antibiotic resistance', 'level': 3, 'score': 0.04625398}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.04485002}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018784', 'descriptor_name': 'Abdominal Abscess', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D018784', 'descriptor_name': 'Abdominal Abscess', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007710', 'descriptor_name': 'Klebsiella Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010397', 'descriptor_name': 'Penicillanic Acid', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D010878', 'descriptor_name': 'Piperacillin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018784', 'descriptor_name': 'Abdominal Abscess', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077723', 'descriptor_name': 'Cefepime', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007710', 'descriptor_name': 'Klebsiella Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007711', 'descriptor_name': 'Klebsiella pneumoniae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007711', 'descriptor_name': 'Klebsiella pneumoniae', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007711', 'descriptor_name': 'Klebsiella pneumoniae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010397', 'descriptor_name': 'Penicillanic Acid', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D010397', 'descriptor_name': 'Penicillanic Acid', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D010397', 'descriptor_name': 'Penicillanic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010878', 'descriptor_name': 'Piperacillin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010878', 'descriptor_name': 'Piperacillin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000078142', 'descriptor_name': 'Tazobactam', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.41.5.1053', 'pdf_url': 'https://aac.asm.org/content/aac/41/5/1053.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc163849', 'pdf_url': 'https://europepmc.org/articles/pmc163849?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163849', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9145868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.41.5.1053', 'pdf_url': 'https://aac.asm.org/content/aac/41/5/1053.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'No poverty', 'score': 0.67, 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1539678687', 'https://openalex.org/W1581962345', 'https://openalex.org/W1789686925', 'https://openalex.org/W1972592665', 'https://openalex.org/W1979910535', 'https://openalex.org/W1985111854', 'https://openalex.org/W2003026290', 'https://openalex.org/W2014133550', 'https://openalex.org/W2014655100', 'https://openalex.org/W2016815689', 'https://openalex.org/W2034941908', 'https://openalex.org/W2039118393', 'https://openalex.org/W2045908270', 'https://openalex.org/W2046492569', 'https://openalex.org/W2048101866', 'https://openalex.org/W2068459979', 'https://openalex.org/W2076374902', 'https://openalex.org/W2078340635', 'https://openalex.org/W2079949412', 'https://openalex.org/W2081217984', 'https://openalex.org/W2091078208', 'https://openalex.org/W2119630062', 'https://openalex.org/W2120939603', 'https://openalex.org/W2121282317', 'https://openalex.org/W2124512418', 'https://openalex.org/W2128940357', 'https://openalex.org/W2143065304', 'https://openalex.org/W2146241292', 'https://openalex.org/W2152283677', 'https://openalex.org/W2153743397', 'https://openalex.org/W2159445367', 'https://openalex.org/W2165488979'], 'related_works': ['https://openalex.org/W3134087599', 'https://openalex.org/W2425760945', 'https://openalex.org/W2348497797', 'https://openalex.org/W2228625187', 'https://openalex.org/W2136654843', 'https://openalex.org/W2102368355', 'https://openalex.org/W2051636921', 'https://openalex.org/W2016031091', 'https://openalex.org/W1996500197', 'https://openalex.org/W1963659521'], 'abstract_inverted_index': {'The': [0], 'in': [1, 18, 60, 71, 125, 131, 175], 'vivo': [2, 126], 'activities': [3], 'of': [4, 12, 22, 28, 39, 42, 55, 111, 143, 173, 178, 201], 'piperacillin-tazobactam': [5], 'and': [6, 16, 140, 157, 199], 'cefepime': [7], 'were': [8, 74], 'compared': [9, 57], 'with': [10, 25, 58], 'those': [11, 59], 'ticarcillin-clavulanate,': [13, 89], 'ceftazidime,': [14, 40, 81], 'cefotaxime,': [15, 97], 'imipenem': [17], 'a': [19, 26, 137, 196], 'rat': [20], 'model': [21], 'intra-abdominal': [23], 'abscess': [24], 'strain': [27], 'Klebsiella': [29], 'pneumoniae': [30, 186], 'elaborating': [31], 'an': [32], 'extended-spectrum': [33, 183], 'beta-lactamase': [34], '(TEM-26).': [35], 'With': [36], 'the': [37, 43, 53, 112, 171, 176], 'exception': [38], 'all': [41], 'antimicrobial': [44], 'agents': [45], 'significantly': [46], 'reduced': [47], 'bacterial': [48], 'counts': [49, 66], 'within': [50], 'abscesses': [51], 'at': [52], 'end': [54], 'therapy': [56, 144], 'untreated': [61], 'controls.': [62], 'Residual': [63], 'viable': [64], 'cell': [65], '(mean': [67], '+/-': [68, 79, 83, 87, 91, 95, 99, 103], 'standard': [69], 'deviation': [70], 'log10': [72], 'CFU/gram)': [73], 'as': [75], 'follows:': [76], 'control,': [77], '8.76': [78], '0.97;': [80], '8.00': [82], '0.76;': [84], 'piperacillin-tazobactam,': [85], '3.87': [86], '1.72;': [88], '3.74': [90], '1.34;': [92], 'cefepime,': [93], '3.15': [94], '1.19;': [96], '2.61': [98], '0.77;': [100], 'imipenem,': [101], '2.41': [102], '0.93.': [104], 'Imipenem': [105], 'was': [106, 119], 'more': [107], 'effective': [108, 121], 'than': [109], 'either': [110], 'inhibitor': [113], 'combinations': [114], '(P': [115], '&lt;': [116], '0.05).': [117], 'Cefotaxime': [118], 'unexpectedly': [120], 'given': [122], 'its': [123], 'poor': [124], 'activity': [127], 'against': [128], 'this': [129], 'organism': [130, 198], 'our': [132], 'earlier': [133], 'studies,': [134], 'which': [135], 'used': [136], 'different': [138], 'dose': [139], 'total': [141], 'duration': [142], '(L.': [145], 'B.': [146], 'Rice,': [147], 'J.': [148], 'D.': [149], 'C.': [150, 159], 'Yao,': [151], 'K.': [152, 185], 'Klimm,': [153], 'G.': [154], 'M.': [155], 'Eliopoulos,': [156], 'R.': [158], 'Moellering,': [160], 'Jr.,': [161], 'Antimicrob.': [162], 'Agents': [163], 'Chemother.': [164], '35:1243-1244,': [165], '1991).': [166], 'These': [167], 'observations': [168], 'suggest': [169], 'that': [170], 'effectiveness': [172], 'cephalosporins': [174], 'treatment': [177], 'experimental': [179], 'infections': [180], 'caused': [181], 'by': [182], 'beta-lactamase-producing': [184], 'may': [187], 'be': [188], 'highly': [189], 'dependent': [190], 'on': [191], 'dosing': [192], 'regimens,': [193], 'even': [194], 'for': [195], 'specific': [197], 'site': [200], 'infection.': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2120588426', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-17T10:00:06.564040', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
