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'can': [21, 35, 151], 'act': [22], 'as': [23], 'chaperone': [25, 97], 'when': [26, 47], 'interacts': [28], 'with': [29, 92], 'monomeric': [30], 'syntaxin': [31, 93, 116], '1A,': [32], 'and': [33, 95, 106, 110, 153], 'activate': [36], 'soluble': [37], 'N-ethylmaleimide-sensitive': [38], 'factor': [39], 'attachment': [40], 'protein': [41], 'receptors': [42], '(SNAREs)': [43], 'for': [44], 'fusion': [46, 109, 126], 'binds': [49], 'SNARE': [51, 104], 'complexes.': [52], 'Although': [53], 'both': [54], 'modes': [55, 147], 'binding': [57, 146], 'involve': [58], 'the': [59, 84, 129, 143], 'central': [60, 85, 131], 'cavity': [61, 86], 'Munc18-1,': [63], 'their': [64], 'precise': [65], 'molecular': [66], 'mechanisms': [67], 'action': [69], 'are': [70], 'not': [71], 'fully': [72], 'understood.': [73], 'In': [74], 'this': [75], 'paper,': [76], 'we': [77], 'describe': [78], 'novel': [80], 'Munc18-1': [81, 122, 130], 'mutant': [82], 'that': [87], 'showed': [88], 'reduced': [90], 'interaction': [91], '1A': [94, 117], 'impaired': [96], 'function,': [98], 'but': [99], 'still': [100], 'bound': [101], 'assembled': [103], 'complexes': [105], 'promoted': [107], 'liposome': [108, 125], 'secretion': [111], 'neuroendocrine': [113], 'cells.': [114], 'Soluble': [115], 'H3': [118], 'domain': [119], 'partially': [120], 'blocks': [121], 'activation': [123], 'by': [127, 148], 'occupying': [128], 'cavity.': [132], 'Our': [133], 'findings': [134], 'lead': [135], 'us': [136], 'propose': [138], 'transition': [140], 'model': [141], 'between': [142], 'two': [144], 'distinct': [145], 'which': [149], 'Munc18': [150], 'control': [152], 'assist': [154], 'SNARE-complex': [156], 'assembly': [157], 'during': [158], 'neurotransmitter': [159], 'release.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2120499783', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-08T13:04:00.403485', 'created_date': '2016-06-24'}