Title: Constitutive expression of hepatic cytochrome P450 genes
Abstract: The FASEB JournalVolume 10, Issue 10 p. 1112-1117 Cytochromes P450 6 Constitutive expression of hepatic cytochrome P450 genes Frank J. Gonzalez, Corresponding Author Frank J. Gonzalez n/[email protected] Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20892 USATo whom correspondence and reprint requests should be addressed, at: Building 37, Room 3E24, National Institutes of Health, Bethesda, MD 20892, USASearch for more papers by this authorYing-Hue Lee, Ying-Hue Lee Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20892 USASearch for more papers by this author Frank J. Gonzalez, Corresponding Author Frank J. Gonzalez n/[email protected] Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20892 USATo whom correspondence and reprint requests should be addressed, at: Building 37, Room 3E24, National Institutes of Health, Bethesda, MD 20892, USASearch for more papers by this authorYing-Hue Lee, Ying-Hue Lee Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20892 USASearch for more papers by this author First published: 01 August 1996 https://doi.org/10.1096/fasebj.10.10.8751713Citations: 94AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Cytochromes P450 are a superfamily of heme proteins involved in oxidative metabolism of endogenous chemicals such as steroid hormones and human-made xenobiotics including drugs and environmental pollutants. Hundreds of P450s have been demonstrated by cDNA and gene cloning in animals, plants, fungi, and bacteria. Most of the mammalian xenobiotic-metabolizing P450s, found within the eight subfamilies comprising the CYP2 family, are constitutively expressed in the liver. Transcriptional activation of individual P450 genes in the liver commences at distinct stages of development. Some P450 genes are preferentially expressed in one sex. The mechanisms of liver-specific expression of the P450 genes are quite diverse. Recent studies have found that several different liver-enriched transcription factors including HNF-1 α, HNF-3, HNF-4, and C/EBPβ, and the more ubiquitously expressed factors Spl, GABP α/β, and NF2d9 are responsible for governing the transcription of P450 genes. In some cases, more than one factor can influence expression depending on the developmental stage of the animal, and ubiquitously expressed factors such as Spl have been found to cooperate with liver-enriched factors to maximally activate transcription of P450 genes. STAT protein- and phospholipase A2-mediated signal transduction have also been implicated in sex-dependent expression of certain P4S0 genes. These studies indicate that P450 genes, even within the same subfamily in the same mammalian species, can have unique regulatory circuits.—Gonzalez, F. J., Lee, Y.-H. Constitutive expression of hepatic cytochrome P450 genes. FASEB J. 10, 1112-1117 Citing Literature Volume10, Issue10August 1996Pages 1112-1117 RelatedInformation
Publication Year: 1996
Publication Date: 1996-08-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 126
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