Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2120338011', 'doi': 'https://doi.org/10.1242/dev.072652', 'title': 'SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice', 'display_name': 'SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice', 'publication_year': 2012, 'publication_date': '2012-03-15', 'ids': {'openalex': 'https://openalex.org/W2120338011', 'doi': 'https://doi.org/10.1242/dev.072652', 'mag': '2120338011', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22318228'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.072652', 'pdf_url': 'https://journals.biologists.com/dev/article-pdf/139/6/1153/1177446/1153.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.biologists.com/dev/article-pdf/139/6/1153/1177446/1153.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010146375', 'display_name': 'Satoru Sasagawa', 'orcid': 'https://orcid.org/0000-0001-5769-8700'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}, {'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}, {'id': 'https://openalex.org/I4210151107', 'display_name': 'Osaka Medical Center for Cancer and Cardiovascular Diseases', 'ror': 'https://ror.org/05xvwhv53', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151107']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoru Sasagawa', 'raw_affiliation_strings': ['Department of Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-0025, Japan.', 'Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'Japan Science and Technology Agency, CREST, Tokyo, 102-0075, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Japan Science and Technology Agency, CREST, Tokyo, 102-0075, Japan.', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': 'Department of Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-0025, Japan.', 'institution_ids': ['https://openalex.org/I4210151107']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031128573', 'display_name': 'Hiroshi Takemori', 'orcid': 'https://orcid.org/0000-0002-1815-2964'}, 'institutions': [{'id': 'https://openalex.org/I4210086383', 'display_name': 'National Institute of Biomedical Innovation, Health and Nutrition', 'ror': 'https://ror.org/001rkbe13', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086383']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Takemori', 'raw_affiliation_strings': ['Laboratory of Cell Signal and Metabolism, National Institute of Biomedical Innovation, 7-6-9 Asagi, Ibaraki, Osaka 567-0085, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cell Signal and Metabolism, National Institute of Biomedical Innovation, 7-6-9 Asagi, Ibaraki, Osaka 567-0085, Japan.', 'institution_ids': ['https://openalex.org/I4210086383']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042208164', 'display_name': 'Tatsuya Uebi', 'orcid': 'https://orcid.org/0000-0001-8339-4241'}, 'institutions': [{'id': 'https://openalex.org/I4210086383', 'display_name': 'National Institute of Biomedical Innovation, Health and Nutrition', 'ror': 'https://ror.org/001rkbe13', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086383']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tatsuya Uebi', 'raw_affiliation_strings': ['Laboratory of Cell Signal and Metabolism, National Institute of Biomedical Innovation, 7-6-9 Asagi, Ibaraki, Osaka 567-0085, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cell Signal and Metabolism, National Institute of Biomedical Innovation, 7-6-9 Asagi, Ibaraki, Osaka 567-0085, Japan.', 'institution_ids': ['https://openalex.org/I4210086383']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017697955', 'display_name': 'Daisuke Ikegami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Daisuke Ikegami', 'raw_affiliation_strings': ['Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041389361', 'display_name': 'Kazuko Hiramatsu', 'orcid': 'https://orcid.org/0000-0002-2239-873X'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kunihiko Hiramatsu', 'raw_affiliation_strings': ['Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015693631', 'display_name': 'Shiro Ikegawa', 'orcid': 'https://orcid.org/0000-0003-0316-2147'}, 'institutions': [{'id': 'https://openalex.org/I4210150921', 'display_name': 'RIKEN Center for Integrative Medical Sciences', 'ror': 'https://ror.org/04mb6s476', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210110652', 'https://openalex.org/I4210150921']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shiro Ikegawa', 'raw_affiliation_strings': ['Laboratory of Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo 108-8639, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo 108-8639, Japan.', 'institution_ids': ['https://openalex.org/I4210150921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100601417', 'display_name': 'Hideki Yoshikawa', 'orcid': 'https://orcid.org/0000-0002-0268-9409'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideki Yoshikawa', 'raw_affiliation_strings': ['Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072360761', 'display_name': 'Noriyuki Tsumaki', 'orcid': 'https://orcid.org/0000-0002-0520-3654'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}, {'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}, {'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Noriyuki Tsumaki', 'raw_affiliation_strings': ['Center for iPS Cell Research and Application, Kyoto-University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.', 'Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'Japan Science and Technology Agency, CREST, Tokyo, 102-0075, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Department of Orthopedic Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Japan Science and Technology Agency, CREST, Tokyo, 102-0075, Japan.', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': 'Center for iPS Cell Research and Application, Kyoto-University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.', 'institution_ids': ['https://openalex.org/I22299242']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.572, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 84, 'citation_normalized_percentile': {'value': 0.89954, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '139', 'issue': '6', 'first_page': '1153', 'last_page': '1163'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11219', 'display_name': 'Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11219', 'display_name': 'Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11591', 'display_name': 'NF-?B Signaling in Inflammation and Cancer', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis and Cartilage Repair', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/endochondral-ossification', 'display_name': 'Endochondral ossification', 'score': 0.7181014}, {'id': 'https://openalex.org/keywords/chondrocyte', 'display_name': 'Chondrocyte', 'score': 0.535043}], 'concepts': [{'id': 'https://openalex.org/C2781403057', 'wikidata': 'https://www.wikidata.org/wiki/Q775480', 'display_name': 'Chondrocyte', 'level': 3, 'score': 0.85830414}, {'id': 'https://openalex.org/C17938293', 'wikidata': 'https://www.wikidata.org/wiki/Q3312710', 'display_name': 'Endochondral ossification', 'level': 3, 'score': 0.7181014}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6897264}, {'id': 'https://openalex.org/C2778842504', 'wikidata': 'https://www.wikidata.org/wiki/Q1121544', 'display_name': 'Ossification', 'level': 2, 'score': 0.56230396}, {'id': 'https://openalex.org/C167414201', 'wikidata': 'https://www.wikidata.org/wiki/Q1955391', 'display_name': 'Muscle hypertrophy', 'level': 2, 'score': 0.5520749}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5366122}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.50882155}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.44099277}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34281817}], 'mesh': [{'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020219', 'descriptor_name': 'Chondrogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024161', 'descriptor_name': 'Collagen Type XI', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024161', 'descriptor_name': 'Collagen Type XI', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004392', 'descriptor_name': 'Dwarfism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004392', 'descriptor_name': 'Dwarfism', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006655', 'descriptor_name': 'Histone Deacetylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006655', 'descriptor_name': 'Histone Deacetylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006984', 'descriptor_name': 'Hypertrophy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064326', 'descriptor_name': 'MEF2 Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018006', 'descriptor_name': 'Myogenic Regulatory Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018006', 'descriptor_name': 'Myogenic Regulatory Factors', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.072652', 'pdf_url': 'https://journals.biologists.com/dev/article-pdf/139/6/1153/1177446/1153.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22318228', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dev.072652', 'pdf_url': 'https://journals.biologists.com/dev/article-pdf/139/6/1153/1177446/1153.pdf', 'source': {'id': 'https://openalex.org/S86558740', 'display_name': 'Development', 'issn_l': '0950-1991', 'issn': ['0950-1991', '1477-9129'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1521657513', 'https://openalex.org/W1965306136', 'https://openalex.org/W1967273423', 'https://openalex.org/W1970083434', 'https://openalex.org/W1976492308', 'https://openalex.org/W1983529894', 'https://openalex.org/W1990638016', 'https://openalex.org/W1993851741', 'https://openalex.org/W1997812904', 'https://openalex.org/W2036982172', 'https://openalex.org/W2049157134', 'https://openalex.org/W2054141235', 'https://openalex.org/W2059182847', 'https://openalex.org/W2094192662', 'https://openalex.org/W2098326006', 'https://openalex.org/W2098537129', 'https://openalex.org/W2102884982', 'https://openalex.org/W2107016002', 'https://openalex.org/W2122367477', 'https://openalex.org/W2127015656', 'https://openalex.org/W2138319716', 'https://openalex.org/W2138960046', 'https://openalex.org/W2149193631', 'https://openalex.org/W2150134228', 'https://openalex.org/W2150681906', 'https://openalex.org/W2156726032', 'https://openalex.org/W2158973504', 'https://openalex.org/W2160572920', 'https://openalex.org/W4230453603', 'https://openalex.org/W4239370680'], 'related_works': ['https://openalex.org/W4232436370', 'https://openalex.org/W3209083126', 'https://openalex.org/W3186518064', 'https://openalex.org/W3121676392', 'https://openalex.org/W3113789775', 'https://openalex.org/W2761250921', 'https://openalex.org/W2745197840', 'https://openalex.org/W2147083273', 'https://openalex.org/W2010247342', 'https://openalex.org/W1579653634'], 'abstract_inverted_index': {'Chondrocyte': [0, 104], 'hypertrophy': [1, 30, 100, 105, 125, 245], 'is': [2, 13], 'crucial': [3, 157, 198], 'for': [4, 188, 240], 'endochondral': [5], 'ossification,': [6], 'but': [7, 169], 'the': [8, 55, 63, 69, 86, 94, 112, 116, 119, 135, 149, 164, 173, 192, 221, 232], 'mechanism': [9], 'underlying': [10], 'this': [11], 'process': [12], 'not': [14], 'fully': [15], 'understood.': [16], 'We': [17], 'report': [18], 'that': [19, 184], 'salt-inducible': [20], 'kinase': [21], '3': [22], '(SIK3)': [23], 'deficiency': [24], 'causes': [25], 'severe': [26], 'inhibition': [27], 'of': [28, 54, 66, 89, 118, 137, 159, 200, 211, 215], 'chondrocyte': [29, 99, 124, 160, 201, 244], 'in': [31, 62, 68, 79, 85, 93, 126, 134, 142, 145, 148, 152, 163, 166, 172, 175, 191, 207, 218, 231, 242], 'mice.': [32, 81, 154], 'SIK3-deficient': [33, 80, 90, 127, 167, 222], 'mice': [34, 91], 'showed': [35], 'dwarfism': [36], 'as': [37], 'they': [38], 'aged,': [39], 'whereas': [40], 'body': [41], 'size': [42], 'was': [43, 92, 101, 106, 132, 170, 186, 225], 'unaffected': [44], 'during': [45, 246], 'embryogenesis.': [46], 'Anatomical': [47], 'and': [48, 58, 72, 74, 111, 139, 147, 180, 220, 248], 'histological': [49], 'analyses': [50, 182], 'revealed': [51], 'marked': [52], 'expansion': [53], 'growth': [56, 150, 216, 249], 'plate': [57, 250], 'articular': [59], 'cartilage': [60, 223], 'regions': [61], 'limbs,': [64], 'accumulation': [65], 'chondrocytes': [67, 114, 141], 'sternum,': [70], 'ribs': [71], 'spine,': [73], 'impaired': [75, 123], 'skull': [76], 'bone': [77], 'formation': [78], 'The': [82], 'primary': [83], 'phenotype': [84, 224], 'skeletal': [87], 'tissue': [88], 'humerus': [95], 'at': [96], 'E14.5,': [97], 'where': [98], 'markedly': [102], 'delayed.': [103], 'severely': [107], 'blocked': [108], 'until': [109], 'E18.5,': [110], 'proliferative': [113], 'occupied': [115], 'inside': [117], 'humerus.': [120, 233], 'Consistent': [121], 'with': [122], 'mice,': [128], 'native': [129], 'SIK3': [130, 185, 212, 229, 241], 'expression': [131, 230], 'detected': [133], 'cytoplasm': [136, 174], 'prehypertrophic': [138], 'hypertrophic': [140, 177], 'developing': [143], 'bones': [144], 'embryos': [146], 'plates': [151, 217], 'postnatal': [153], 'HDAC4,': [155], 'a': [156, 197], 'repressor': [158], 'hypertrophy,': [161, 202], 'remained': [162], 'nuclei': [165], 'chondrocytes,': [168], 'localized': [171], 'wild-type': [176], 'chondrocytes.': [178], 'Molecular': [179], 'cellular': [181], 'demonstrated': [183], 'required': [187], 'anchoring': [189], 'HDAC4': [190, 206], 'cytoplasm,': [193], 'thereby': [194], 'releasing': [195], 'MEF2C,': [196], 'facilitator': [199], 'from': [203], 'suppression': [204], 'by': [205, 227], 'nuclei.': [208], 'Chondrocyte-specific': [209], 'overexpression': [210], 'induced': [213], 'closure': [214], 'adulthood,': [219], 'rescued': [226], 'transgenic': [228], 'These': [234], 'results': [235], 'demonstrate': [236], 'an': [237], 'essential': [238], 'role': [239], 'facilitating': [243], 'skeletogenesis': [247], 'maintenance.': [251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2120338011', 'counts_by_year': [{'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-11T15:22:12.351744', 'created_date': '2016-06-24'}