Publication Information

{'id': 'https://openalex.org/W2119825626', 'doi': 'https://doi.org/10.1172/jci27698', 'title': 'Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity', 'display_name': 'Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity', 'publication_year': 2006, 'publication_date': '2006-06-08', 'ids': {'openalex': 'https://openalex.org/W2119825626', 'doi': 'https://doi.org/10.1172/jci27698', 'mag': '2119825626', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16767218', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1474818'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci27698', 'pdf_url': 'http://www.jci.org/articles/view/27698/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/27698/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001092701', 'display_name': 'Jeremy Chien', 'orcid': 'https://orcid.org/0000-0003-4744-8374'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'J. Chien', 'raw_affiliation_strings': ['Mayo Clinic College of Medicine and Science;'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic College of Medicine and Science;', 'institution_ids': ['https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5001092701'], 'corresponding_institution_ids': ['https://openalex.org/I1330342723'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.082, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 146, 'citation_normalized_percentile': {'value': 0.950055, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '116', 'issue': '7', 'first_page': '1994', 'last_page': '2004'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13648', 'display_name': 'Cerebrovascular and genetic disorders', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13648', 'display_name': 'Cerebrovascular and genetic disorders', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12049', 'display_name': 'Tuberous Sclerosis Complex Research', 'score': 0.983, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9767, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.8782816}, {'id': 'https://openalex.org/C2777292972', 'wikidata': 'https://www.wikidata.org/wiki/Q423762', 'display_name': 'Paclitaxel', 'level': 3, 'score': 0.839977}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.7957322}, {'id': 'https://openalex.org/C2780427987', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian cancer', 'level': 3, 'score': 0.725502}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.7022071}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.6082446}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5998182}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4548058}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4480878}, {'id': 'https://openalex.org/C2777807008', 'wikidata': 'https://www.wikidata.org/wiki/Q87324999', 'display_name': 'Serine protease', 'level': 4, 'score': 0.4398115}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36799282}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32169136}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28178066}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.18677953}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.17638063}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.10173285}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0664168}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004358', 'descriptor_name': 'Drug Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074289', 'descriptor_name': 'High-Temperature Requirement A Serine Peptidase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci27698', 'pdf_url': 'http://www.jci.org/articles/view/27698/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2434/574496', 'pdf_url': 'https://air.unimi.it/bitstream/2434/574496/2/gep055.pdf', 'source': {'id': 'https://openalex.org/S4306400516', 'display_name': 'Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I189158943', 'host_organization_name': 'University of Milan', 'host_organization_lineage': ['https://openalex.org/I189158943'], 'host_organization_lineage_names': ['University of Milan'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1474818', 'pdf_url': 'https://europepmc.org/articles/pmc1474818?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474818', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16767218', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci27698', 'pdf_url': 'http://www.jci.org/articles/view/27698/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.88, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1211118294', 'https://openalex.org/W1480984787', 'https://openalex.org/W1489284756', 'https://openalex.org/W1492521210', 'https://openalex.org/W1604468403', 'https://openalex.org/W161930446', 'https://openalex.org/W1740666950', 'https://openalex.org/W1819407996', 'https://openalex.org/W1966798559', 'https://openalex.org/W1970930172', 'https://openalex.org/W1979088094', 'https://openalex.org/W1980331623', 'https://openalex.org/W1994117795', 'https://openalex.org/W1996474536', 'https://openalex.org/W2006434892', 'https://openalex.org/W2007608938', 'https://openalex.org/W2009885873', 'https://openalex.org/W2019533472', 'https://openalex.org/W2020999669', 'https://openalex.org/W2031138807', 'https://openalex.org/W2032413974', 'https://openalex.org/W2033799417', 'https://openalex.org/W2034915619', 'https://openalex.org/W2050425919', 'https://openalex.org/W2055397209', 'https://openalex.org/W2065825082', 'https://openalex.org/W2067000923', 'https://openalex.org/W2068285413', 'https://openalex.org/W2069657245', 'https://openalex.org/W2070055534', 'https://openalex.org/W2070718488', 'https://openalex.org/W2071202158', 'https://openalex.org/W2079119334', 'https://openalex.org/W2080156248', 'https://openalex.org/W2086189280', 'https://openalex.org/W2087450028', 'https://openalex.org/W2099617191', 'https://openalex.org/W2102443458', 'https://openalex.org/W2110075925', 'https://openalex.org/W2110483280', 'https://openalex.org/W2110975163', 'https://openalex.org/W2117612500', 'https://openalex.org/W2125988618', 'https://openalex.org/W2126654232', 'https://openalex.org/W2126699849', 'https://openalex.org/W2134065531', 'https://openalex.org/W2147787249', 'https://openalex.org/W2150863963', 'https://openalex.org/W2152974369', 'https://openalex.org/W2153456878', 'https://openalex.org/W2153689486', 'https://openalex.org/W2164277862', 'https://openalex.org/W2167805334', 'https://openalex.org/W2415874177', 'https://openalex.org/W4252125722', 'https://openalex.org/W4253057903', 'https://openalex.org/W4388156733', 'https://openalex.org/W45574792', 'https://openalex.org/W61514466'], 'related_works': ['https://openalex.org/W4385496679', 'https://openalex.org/W3152185824', 'https://openalex.org/W3149674127', 'https://openalex.org/W3147219444', 'https://openalex.org/W2077985528', 'https://openalex.org/W2053380829', 'https://openalex.org/W2053306150', 'https://openalex.org/W2030595392', 'https://openalex.org/W2002655626', 'https://openalex.org/W1987294960'], 'abstract_inverted_index': {'Resistance': [0], 'to': [1, 41, 107, 152, 180], 'chemotherapy': [2, 42, 108], 'presents': [3], 'a': [4, 91, 101, 133, 154], 'serious': [5], 'challenge': [6], 'in': [7, 35, 78, 90, 111, 173, 181], 'the': [8], 'successful': [9], 'treatment': [10], 'of': [11, 29, 48, 58, 83, 98, 104, 130, 143, 171], 'various': [12], 'cancers': [13, 177], 'and': [14, 52, 62, 72, 81, 114, 164, 167, 175], 'is': [15, 32], 'mainly': [16], 'responsible': [17], 'for': [18], 'mortality': [19], 'associated': [20], 'with': [21, 122, 138, 140], 'disseminated': [22], 'cancers.': [23], 'Here': [24], 'we': [25, 150], 'show': [26], 'that': [27, 169], 'expression': [28, 57, 66], 'HtrA1,': [30], 'which': [31, 158], 'frequently': [33], 'downregulated': [34], 'ovarian': [36, 113, 123, 174], 'cancer,': [37], 'influences': [38], 'tumor': [39], 'response': [40, 106, 135], 'by': [43, 69, 157], 'modulating': [44], 'chemotherapy-induced': [45], 'cytotoxicity.': [46, 64], 'Downregulation': [47], 'HtrA1': [49, 59, 65, 86, 99, 131, 144, 161, 172], 'attenuated': [50], 'cisplatin-': [51, 61], 'paclitaxel-induced': [53, 63], 'cytotoxicity,': [54], 'while': [55], 'forced': [56], 'enhanced': [60], 'was': [67, 109], 'upregulated': [68], 'both': [70, 112], 'cisplatin': [71], 'paclitaxel': [73], 'treatment.': [74], 'This': [75], 'upregulation': [76], 'resulted': [77], 'limited': [79], 'autoproteolysis': [80], 'activation': [82], 'HtrA1.': [84], 'Active': [85], 'induces': [87], 'cell': [88], 'death': [89], 'serine': [92, 159], 'protease-dependent': [93], 'manner.': [94], 'The': [95], 'potential': [96], 'role': [97], 'as': [100], 'predictive': [102], 'factor': [103], 'clinical': [105], 'assessed': [110], 'gastric': [115, 125, 176], 'cancer': [116], 'patients': [117], 'receiving': [118], 'cisplatin-based': [119], 'regimens.': [120], 'Patients': [121], 'or': [124], 'tumors': [126], 'expressing': [127], 'higher': [128, 134], 'levels': [129, 142], 'showed': [132], 'rate': [136], 'compared': [137], 'those': [139], 'lower': [141], 'expression.': [145], 'These': [146], 'findings': [147], 'uncover': [148], 'what': [149], 'believe': [151], 'be': [153], 'novel': [155], 'pathway': [156], 'protease': [160], 'mediates': [162], 'paclitaxel-': [163], 'cisplatin-induced': [165], 'cytotoxicity': [166], 'suggest': [168], 'loss': [170], 'may': [178], 'contribute': [179], 'vivo': [182], 'chemoresistance.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2119825626', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-14T21:52:01.823398', 'created_date': '2016-06-24'}