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'accumulation': [64], 'phosphatidylinositol-(3,4,5)-P3,': [66], 'which': [67, 155, 201], 'is': [68, 211], 'required': [69], 'for': [70, 194], 'activation': [71], 'protein': [73], 'kinase': [74], 'B': [75], '(PKB)/Akt,': [76], 'downstream': [78], 'target': [79], 'PI3-kinase': [81], 'cell': [85], 'survival': [86], 'factor.4-8': [87], '\n\nWhile': [88], 'up': [89], '81%': [91], 'CS': [93, 152, 196], 'approximately': [95], '60%': [96], 'BRR': [98, 198], 'cases': [99, 199], 'detectable': [101], 'germline': [103], 'mutations,': [104], 'no': [105, 202, 221], 'coding': [109], 'region': [110, 171], 'exon-intron': [112], 'boundaries': [113], 'found': [118], 'remaining': [121], 'affected': [122], 'subjects.2': [123], '9-13Informative': [124], 'mutation': [126, 204], 'negative': [127], 'families': [128, 153], 'shown': [131], 'be': [133, 192], 'linked': [134], '10q23': [137, 158], 'region,': [138, 185], 'where': [139], 'lies,2': [141], '14': [142], 'although': [143], 'there': [145], 'report': [149], 'linkage': [156], 'excluded.9': [161], 'This': [162], 'raised': [164], 'possibility': [166], 'either': [168], 'regulatory': [170], 'not': [176], 'included': [177], 'previous': [179], 'studies,': [180], 'such': [181, 218], 'promoter': [184], 'another,': [187], 'closely': [188], 'located': [189], 'might': [191], 'responsible': [193], 'found.': [207], 'The': [208], 'first': [209], 'alternative': [210], 'unlikely': [212], 'represent': [214], 'majority': [216], 'cases,': [219], 'evidence': [222], 'transcriptional': [225], 'silencing': [226], 'detected': [229], '…': [231]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2119733304', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-15T13:10:40.400010', 'created_date': '2016-06-24'}