Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2119523362', 'doi': 'https://doi.org/10.4049/jimmunol.1202661', 'title': 'T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response', 'display_name': 'T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response', 'publication_year': 2013, 'publication_date': '2013-03-01', 'ids': {'openalex': 'https://openalex.org/W2119523362', 'doi': 'https://doi.org/10.4049/jimmunol.1202661', 'mag': '2119523362', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23365080'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1202661', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/190/5/2068.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jimmunol.org/content/jimmunol/190/5/2068.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101634943', 'display_name': 'Xiaomei Yang', 'orcid': 'https://orcid.org/0000-0002-4081-4207'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}, {'id': 'https://openalex.org/I173899330', 'display_name': 'Henan University', 'ror': 'https://ror.org/003xyzq10', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173899330']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaomei Yang', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', '†Institute of Immunology, Medical School of Henan University, Kaifeng 475001, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}, {'raw_affiliation_string': '†Institute of Immunology, Medical School of Henan University, Kaifeng 475001, China;', 'institution_ids': ['https://openalex.org/I173899330']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048171845', 'display_name': 'Xingwei Jiang', 'orcid': 'https://orcid.org/0009-0002-1870-640X'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xingwei Jiang', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051594298', 'display_name': 'Guojiang Chen', 'orcid': 'https://orcid.org/0009-0003-7289-0495'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guojiang Chen', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101642129', 'display_name': 'Xiao Yan', 'orcid': 'https://orcid.org/0000-0002-8407-8360'}, 'institutions': [{'id': 'https://openalex.org/I4210132375', 'display_name': 'First Affiliated Hospital of Chinese PLA General Hospital', 'ror': 'https://ror.org/039713658', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210132375']}, {'id': 'https://openalex.org/I4210160531', 'display_name': "Chinese People's Liberation Army", 'ror': 'https://ror.org/05tf9r976', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210160531']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Xiao', 'raw_affiliation_strings': ["‡Department of Respiratory Diseases, First Affiliated Hospital of the Chinese People's Liberation Army General Hospital, Beijing 100037, China; and"], 'affiliations': [{'raw_affiliation_string': "‡Department of Respiratory Diseases, First Affiliated Hospital of the Chinese People's Liberation Army General Hospital, Beijing 100037, China; and", 'institution_ids': ['https://openalex.org/I4210132375', 'https://openalex.org/I4210160531']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086774280', 'display_name': 'Shaoxia Geng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I173899330', 'display_name': 'Henan University', 'ror': 'https://ror.org/003xyzq10', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173899330']}, {'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shaoxia Geng', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', '†Institute of Immunology, Medical School of Henan University, Kaifeng 475001, China;'], 'affiliations': [{'raw_affiliation_string': '†Institute of Immunology, Medical School of Henan University, Kaifeng 475001, China;', 'institution_ids': ['https://openalex.org/I173899330']}, {'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054563037', 'display_name': 'Chunyan Kang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210160531', 'display_name': "Chinese People's Liberation Army", 'ror': 'https://ror.org/05tf9r976', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210160531']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunyan Kang', 'raw_affiliation_strings': ["§Nanlou Respiratory Diseases Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China"], 'affiliations': [{'raw_affiliation_string': "§Nanlou Respiratory Diseases Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China", 'institution_ids': ['https://openalex.org/I4210160531']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028915287', 'display_name': 'Tingting Zhou', 'orcid': 'https://orcid.org/0000-0002-5760-736X'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tingting Zhou', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101814743', 'display_name': 'Yukui Zhang', 'orcid': 'https://orcid.org/0000-0002-7481-095X'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yurong Li', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102204680', 'display_name': 'Xiaoqin Guo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoqin Guo', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101586418', 'display_name': 'Xiao He', 'orcid': 'https://orcid.org/0009-0004-9727-467X'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'He Xiao', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100991473', 'display_name': 'Chunmei Hou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunmei Hou', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042614311', 'display_name': 'Renxi Wang', 'orcid': 'https://orcid.org/0000-0003-4130-3334'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Renxi Wang', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089197766', 'display_name': 'Lin Zhou', 'orcid': 'https://orcid.org/0000-0001-6908-0764'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhou Lin', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100609634', 'display_name': 'Xinying Li', 'orcid': 'https://orcid.org/0000-0001-9835-2191'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinying Li', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100518170', 'display_name': 'Jiannan Feng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiannan Feng', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022857808', 'display_name': 'Yuanfang Ma', 'orcid': 'https://orcid.org/0000-0001-5635-2660'}, 'institutions': [{'id': 'https://openalex.org/I173899330', 'display_name': 'Henan University', 'ror': 'https://ror.org/003xyzq10', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I173899330']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuanfang Ma', 'raw_affiliation_strings': ['†Institute of Immunology, Medical School of Henan University, Kaifeng 475001, China;'], 'affiliations': [{'raw_affiliation_string': '†Institute of Immunology, Medical School of Henan University, Kaifeng 475001, China;', 'institution_ids': ['https://openalex.org/I173899330']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060514130', 'display_name': 'Beifen Shen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Beifen Shen', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100380313', 'display_name': 'Yan Li', 'orcid': 'https://orcid.org/0000-0002-2323-8105'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan Li', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101886909', 'display_name': 'Gencheng Han', 'orcid': 'https://orcid.org/0000-0003-1408-878X'}, 'institutions': [{'id': 'https://openalex.org/I142415962', 'display_name': 'Beijing Institute of Education', 'ror': 'https://ror.org/03aefdx31', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I142415962']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gencheng Han', 'raw_affiliation_strings': ['*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China;', 'institution_ids': ['https://openalex.org/I142415962']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.784, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 125, 'citation_normalized_percentile': {'value': 0.999928, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '190', 'issue': '5', 'first_page': '2068', 'last_page': '2079'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12387', 'display_name': 'Role of Galectins in Immunity and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12387', 'display_name': 'Role of Galectins in Immunity and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12463', 'display_name': 'Amoebiasis: Pathogenesis and Clinical Management', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Calcineurin-NFAT Signaling in Transcriptional Regulation', 'score': 0.984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.60976356}, {'id': 'https://openalex.org/keywords/immune-responses', 'display_name': 'Immune Responses', 'score': 0.555723}, {'id': 'https://openalex.org/keywords/immune-regulation', 'display_name': 'Immune Regulation', 'score': 0.528428}], 'concepts': [{'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.7810406}, {'id': 'https://openalex.org/C2776070231', 'wikidata': 'https://www.wikidata.org/wiki/Q14914098', 'display_name': 'TLR4', 'level': 3, 'score': 0.69628716}, {'id': 'https://openalex.org/C2778384902', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Sepsis', 'level': 2, 'score': 0.6690574}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.6120635}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.60976356}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.54721075}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.5430358}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.5238226}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.47531992}, {'id': 'https://openalex.org/C193419808', 'wikidata': 'https://www.wikidata.org/wiki/Q1645075', 'display_name': 'Acquired immune system', 'level': 3, 'score': 0.47027022}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45212367}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.44910973}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.4424843}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43828928}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.40790725}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.30371025}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.28767502}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.048692882}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072597', 'descriptor_name': 'Hepatitis A Virus Cellular Receptor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008262', 'descriptor_name': 'Macrophage Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051197', 'descriptor_name': 'Toll-Like Receptor 4', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1202661', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/190/5/2068.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23365080', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1202661', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/190/5/2068.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.89, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1493428717', 'https://openalex.org/W1498311899', 'https://openalex.org/W1500123828', 'https://openalex.org/W1501750993', 'https://openalex.org/W1585589080', 'https://openalex.org/W1628148187', 'https://openalex.org/W1758328146', 'https://openalex.org/W1963504987', 'https://openalex.org/W1973662758', 'https://openalex.org/W1973879517', 'https://openalex.org/W1974872064', 'https://openalex.org/W1980547319', 'https://openalex.org/W1985117788', 'https://openalex.org/W1992412089', 'https://openalex.org/W1997700476', 'https://openalex.org/W1997731331', 'https://openalex.org/W1998077350', 'https://openalex.org/W2001123056', 'https://openalex.org/W2006809031', 'https://openalex.org/W2010817360', 'https://openalex.org/W2013177587', 'https://openalex.org/W2013469022', 'https://openalex.org/W2018207514', 'https://openalex.org/W2035480905', 'https://openalex.org/W2036574174', 'https://openalex.org/W2040665228', 'https://openalex.org/W2043801813', 'https://openalex.org/W2044153851', 'https://openalex.org/W2054142977', 'https://openalex.org/W2055148102', 'https://openalex.org/W2056411965', 'https://openalex.org/W2060678877', 'https://openalex.org/W2066558479', 'https://openalex.org/W2070631889', 'https://openalex.org/W2080735658', 'https://openalex.org/W2082890018', 'https://openalex.org/W2098532474', 'https://openalex.org/W2101363646', 'https://openalex.org/W2105249740', 'https://openalex.org/W2106530602', 'https://openalex.org/W2107777135', 'https://openalex.org/W2109491705', 'https://openalex.org/W2112400160', 'https://openalex.org/W2114445825', 'https://openalex.org/W2119344429', 'https://openalex.org/W2129218540', 'https://openalex.org/W2133449490', 'https://openalex.org/W2135275823', 'https://openalex.org/W2142015379', 'https://openalex.org/W2145577370', 'https://openalex.org/W2149545956', 'https://openalex.org/W2152009213', 'https://openalex.org/W2152358904', 'https://openalex.org/W2159022177', 'https://openalex.org/W2161074777', 'https://openalex.org/W2169288408', 'https://openalex.org/W2172223853', 'https://openalex.org/W2768146862'], 'related_works': ['https://openalex.org/W4231524083', 'https://openalex.org/W4225914417', 'https://openalex.org/W3030144597', 'https://openalex.org/W2951371476', 'https://openalex.org/W2498374562', 'https://openalex.org/W2135436588', 'https://openalex.org/W2088215039', 'https://openalex.org/W2050558417', 'https://openalex.org/W2044757050', 'https://openalex.org/W1551592253'], 'abstract_inverted_index': {'Sepsis': [0], 'is': [1, 104], 'an': [2, 121], 'excessive': [3], 'inflammatory': [4, 86], 'condition': [5], 'with': [6, 48], 'a': [7, 43, 68, 105, 153, 163], 'high': [8], 'mortality': [9], 'rate': [10], 'and': [11, 14, 37, 67, 116, 143, 157], 'limited': [12], 'prediction': [13], 'therapeutic': [15], 'options.': [16], 'In': [17], 'this': [18], 'study,': [19], 'for': [20, 168], 'the': [21, 60, 84, 114, 129], 'first': [22], 'time,': [23], 'to': [24, 77, 83, 124], 'our': [25], 'knowledge,': [26], 'we': [27], 'found': [28], 'that': [29, 53, 102], 'downregulation': [30, 73], 'and/or': [31, 72], 'blockade': [32], 'of': [33, 50, 62, 74, 108, 128, 150, 165], 'T': [34], 'cell': [35], 'Ig': [36], 'mucin': [38], 'domain': [39], 'protein': [40], '3': [41], '(Tim-3),': [42], 'negative': [44, 106, 126, 147], 'immune': [45, 110, 131], 'regulator,': [46], 'correlated': [47], 'severity': [49], 'sepsis,': [51, 89], 'suggesting': [52], 'Tim-3': [54, 75, 91, 103, 115, 133, 151], 'plays': [55], 'important': [56, 122], 'roles': [57], 'in': [58, 64, 88, 93, 160, 172], 'maintaining': [59], 'homeostasis': [61], 'sepsis': [63, 161], 'both': [65], 'humans': [66], 'mouse': [69], 'model.': [70], 'Blockade': [71], 'led': [76], 'increased': [78], 'macrophage': [79], 'activation,': [80], 'which': [81], 'contributed': [82], 'systemic': [85], 'response': [87], 'whereas': [90], 'overexpression': [92], 'macrophages': [94], 'significantly': [95], 'suppressed': [96], 'TLR-mediated': [97, 109], 'proinflammatory': [98], 'cytokine': [99], 'production,': [100], 'indicating': [101], 'regulator': [107], 'responses.': [111], 'Cross-talk': [112], 'between': [113], 'TLR4': [117, 120], 'pathways': [118], 'makes': [119], 'contributor': [123], 'Tim-3-mediated': [125], 'regulation': [127], 'innate': [130, 170], 'response.': [132], 'signaling': [134], 'inhibited': [135], 'LPS-TLR4-mediated': [136], 'NF-κB': [137], 'activation': [138], 'by': [139], 'increasing': [140], 'PI3K-AKT': [141], 'phosphorylation': [142], 'A20': [144], 'activity.': [145], 'This': [146], 'regulatory': [148], 'role': [149], 'reflects': [152], 'new': [154], 'adaptive': [155], 'compensatory': [156], 'protective': [158], 'mechanism': [159], 'victims,': [162], 'finding': [164], 'potential': [166], 'importance': [167], 'modulating': [169], 'responses': [171], 'these': [173], 'patients.': [174]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2119523362', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-16T05:05:22.329173', 'created_date': '2016-06-24'}