Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity

Name: Work Video:
Duration: 3 min 30 s
Dieter Demon; Petra Van Damme; Tom Vanden Berghe; Annelies Deceuninck; Joost Van Durme; Jelle Verspurten; Kenny Helsens; Francis Impens; Magdalena Wejda; Joost Schymkowitz; Frédéric Rousseau; Annemieke Madder; Joël Vandekerckhove; Wim Declercq; Kris Gevaert; Peter Vandenabeele
{'id': 'https://openalex.org/W2119294728', 'doi': 'https://doi.org/10.1074/mcp.m900310-mcp200', 'title': 'Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity', 'display_name': 'Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity', 'publication_year': 2009, 'publication_date': '2009-09-17', 'ids': {'openalex': 'https://openalex.org/W2119294728', 'doi': 'https://doi.org/10.1074/mcp.m900310-mcp200', 'mag': '2119294728', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19759058', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2816020'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m900310-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620339165/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.mcponline.org/article/S1535947620339165/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034508640', 'display_name': 'Dieter Demon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}, {'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Dieter Demon', 'raw_affiliation_strings': ['Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I2802017950']}, {'raw_affiliation_string': 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I32597200']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079964045', 'display_name': 'Petra Van Damme', 'orcid': 'https://orcid.org/0000-0001-9090-027X'}, 'institutions': [{'id': 'https://openalex.org/I4210151194', 'display_name': 'VIB-UGent Center for Medical Biotechnology', 'ror': 'https://ror.org/04hbttm44', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950', 'https://openalex.org/I32597200', 'https://openalex.org/I4210151194']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Petra Van Damme', 'raw_affiliation_strings': ['Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'Departments of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry', 'institution_ids': []}, {'raw_affiliation_string': 'Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'institution_ids': ['https://openalex.org/I4210151194']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087011923', 'display_name': 'Tom Vanden Berghe', 'orcid': 'https://orcid.org/0000-0002-1633-0974'}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}, {'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Tom Vanden Berghe', 'raw_affiliation_strings': ['Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I32597200']}, {'raw_affiliation_string': 'Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I2802017950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061566409', 'display_name': 'Annelies Deceuninck', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Annelies Deceuninck', 'raw_affiliation_strings': ['Departments of Organic Chemistry, Ghent University, Ghent 9000, Belgium, and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Organic Chemistry, Ghent University, Ghent 9000, Belgium, and', 'institution_ids': ['https://openalex.org/I32597200']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070924824', 'display_name': 'Joost Van Durme', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I13469542', 'display_name': 'Vrije Universiteit Brussel', 'ror': 'https://ror.org/006e5kg04', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I13469542']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Joost Van Durme', 'raw_affiliation_strings': ['Switch Laboratory, Flemish Institute for Biotechnology (VIB), Vrije Universiteit Brussel, Brussels 1050, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Switch Laboratory, Flemish Institute for Biotechnology (VIB), Vrije Universiteit Brussel, Brussels 1050, Belgium', 'institution_ids': ['https://openalex.org/I13469542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091738363', 'display_name': 'Jelle Verspurten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}, {'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jelle Verspurten', 'raw_affiliation_strings': ['Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I32597200']}, {'raw_affiliation_string': 'Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I2802017950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010995955', 'display_name': 'Kenny Helsens', 'orcid': 'https://orcid.org/0000-0002-7366-0638'}, 'institutions': [{'id': 'https://openalex.org/I4210151194', 'display_name': 'VIB-UGent Center for Medical Biotechnology', 'ror': 'https://ror.org/04hbttm44', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950', 'https://openalex.org/I32597200', 'https://openalex.org/I4210151194']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Kenny Helsens', 'raw_affiliation_strings': ['Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'Departments of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'institution_ids': ['https://openalex.org/I4210151194']}, {'raw_affiliation_string': 'Departments of Biochemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040383692', 'display_name': 'Francis Impens', 'orcid': 'https://orcid.org/0000-0003-2886-9616'}, 'institutions': [{'id': 'https://openalex.org/I4210151194', 'display_name': 'VIB-UGent Center for Medical Biotechnology', 'ror': 'https://ror.org/04hbttm44', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950', 'https://openalex.org/I32597200', 'https://openalex.org/I4210151194']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Francis Impens', 'raw_affiliation_strings': ['Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'Departments of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'institution_ids': ['https://openalex.org/I4210151194']}, {'raw_affiliation_string': 'Departments of Biochemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084515146', 'display_name': 'Magdalena Wejda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}, {'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Magdalena Wejda', 'raw_affiliation_strings': ['Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I32597200']}, {'raw_affiliation_string': 'Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I2802017950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031589452', 'display_name': 'Joost Schymkowitz', 'orcid': 'https://orcid.org/0000-0003-2020-0168'}, 'institutions': [{'id': 'https://openalex.org/I13469542', 'display_name': 'Vrije Universiteit Brussel', 'ror': 'https://ror.org/006e5kg04', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I13469542']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Joost Schymkowitz', 'raw_affiliation_strings': ['Switch Laboratory, Flemish Institute for Biotechnology (VIB), Vrije Universiteit Brussel, Brussels 1050, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Switch Laboratory, Flemish Institute for Biotechnology (VIB), Vrije Universiteit Brussel, Brussels 1050, Belgium', 'institution_ids': ['https://openalex.org/I13469542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008256216', 'display_name': 'Frédéric Rousseau', 'orcid': 'https://orcid.org/0000-0002-9189-7399'}, 'institutions': [{'id': 'https://openalex.org/I13469542', 'display_name': 'Vrije Universiteit Brussel', 'ror': 'https://ror.org/006e5kg04', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I13469542']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Frederic Rousseau', 'raw_affiliation_strings': ['Switch Laboratory, Flemish Institute for Biotechnology (VIB), Vrije Universiteit Brussel, Brussels 1050, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Switch Laboratory, Flemish Institute for Biotechnology (VIB), Vrije Universiteit Brussel, Brussels 1050, Belgium', 'institution_ids': ['https://openalex.org/I13469542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053786692', 'display_name': 'Annemieke Madder', 'orcid': 'https://orcid.org/0000-0003-0179-7608'}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Annemieke Madder', 'raw_affiliation_strings': ['Departments of Organic Chemistry, Ghent University, Ghent 9000, Belgium, and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Organic Chemistry, Ghent University, Ghent 9000, Belgium, and', 'institution_ids': ['https://openalex.org/I32597200']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108378403', 'display_name': 'Joël Vandekerckhove', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151194', 'display_name': 'VIB-UGent Center for Medical Biotechnology', 'ror': 'https://ror.org/04hbttm44', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950', 'https://openalex.org/I32597200', 'https://openalex.org/I4210151194']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Joël Vandekerckhove', 'raw_affiliation_strings': ['Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'Departments of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'institution_ids': ['https://openalex.org/I4210151194']}, {'raw_affiliation_string': 'Departments of Biochemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041261661', 'display_name': 'Wim Declercq', 'orcid': 'https://orcid.org/0000-0002-8218-2017'}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}, {'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Wim Declercq', 'raw_affiliation_strings': ['Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I32597200']}, {'raw_affiliation_string': 'Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I2802017950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072800163', 'display_name': 'Kris Gevaert', 'orcid': 'https://orcid.org/0000-0002-4237-0283'}, 'institutions': [{'id': 'https://openalex.org/I4210151194', 'display_name': 'VIB-UGent Center for Medical Biotechnology', 'ror': 'https://ror.org/04hbttm44', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950', 'https://openalex.org/I32597200', 'https://openalex.org/I4210151194']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Kris Gevaert', 'raw_affiliation_strings': ['Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'Departments of Biochemistry'], 'affiliations': [{'raw_affiliation_string': 'Department for Medical Protein Research, VIB, Ghent 9000, Belgium,', 'institution_ids': ['https://openalex.org/I4210151194']}, {'raw_affiliation_string': 'Departments of Biochemistry', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089113838', 'display_name': 'Peter Vandenabeele', 'orcid': 'https://orcid.org/0000-0002-6669-8822'}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}, {'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Peter Vandenabeele', 'raw_affiliation_strings': ['Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I32597200']}, {'raw_affiliation_string': 'Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent 9052, Belgium,', 'institution_ids': ['https://openalex.org/I2802017950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5089113838'], 'corresponding_institution_ids': ['https://openalex.org/I32597200', 'https://openalex.org/I2802017950'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 3.056, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.918299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '8', 'issue': '12', 'first_page': '2700', 'last_page': '2714'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12254', 'display_name': 'Machine Learning in Bioinformatics', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteome', 'display_name': 'Proteome', 'score': 0.6050502}, {'id': 'https://openalex.org/keywords/caspase-8', 'display_name': 'Caspase 8', 'score': 0.48886174}, {'id': 'https://openalex.org/keywords/caspase-9', 'display_name': 'Caspase-9', 'score': 0.4201114}], 'concepts': [{'id': 'https://openalex.org/C104397665', 'wikidata': 'https://www.wikidata.org/wiki/Q860947', 'display_name': 'Proteome', 'level': 2, 'score': 0.6050502}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.60191214}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5586461}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.5583098}, {'id': 'https://openalex.org/C2994592520', 'wikidata': 'https://www.wikidata.org/wiki/Q5090496', 'display_name': 'Substrate specificity', 'level': 3, 'score': 0.541007}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49386603}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.49113342}, {'id': 'https://openalex.org/C48297814', 'wikidata': 'https://www.wikidata.org/wiki/Q14911965', 'display_name': 'Caspase 8', 'level': 5, 'score': 0.48886174}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.48543292}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4309407}, {'id': 'https://openalex.org/C2775998712', 'wikidata': 'https://www.wikidata.org/wiki/Q14907714', 'display_name': 'Caspase-9', 'level': 5, 'score': 0.4201114}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.3466318}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30498934}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2601618}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.16217068}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16085923}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.1573532}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053179', 'descriptor_name': 'Caspase 7', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053179', 'descriptor_name': 'Caspase 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m900310-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620339165/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2816020', 'pdf_url': 'https://europepmc.org/articles/pmc2816020?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816020', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19759058', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m900310-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620339165/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Reduced inequalities', 'score': 0.73, 'id': 'https://metadata.un.org/sdg/10'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1555151769', 'https://openalex.org/W1569826234', 'https://openalex.org/W1964383790', 'https://openalex.org/W1970724938', 'https://openalex.org/W1974885063', 'https://openalex.org/W1975417521', 'https://openalex.org/W1975860634', 'https://openalex.org/W1977219317', 'https://openalex.org/W1980745149', 'https://openalex.org/W1981593008', 'https://openalex.org/W1982516441', 'https://openalex.org/W1987785848', 'https://openalex.org/W1988002961', 'https://openalex.org/W1989518640', 'https://openalex.org/W1991455654', 'https://openalex.org/W1997252323', 'https://openalex.org/W2002715724', 'https://openalex.org/W2003014847', 'https://openalex.org/W2004588605', 'https://openalex.org/W2010684046', 'https://openalex.org/W2014578146', 'https://openalex.org/W2020165436', 'https://openalex.org/W2022362803', 'https://openalex.org/W2023490488', 'https://openalex.org/W2025554716', 'https://openalex.org/W2029431569', 'https://openalex.org/W2033290380', 'https://openalex.org/W2037467991', 'https://openalex.org/W2041770258', 'https://openalex.org/W2052759051', 'https://openalex.org/W2052788415', 'https://openalex.org/W2056155809', 'https://openalex.org/W2056745135', 'https://openalex.org/W2057000168', 'https://openalex.org/W2065518020', 'https://openalex.org/W2074912245', 'https://openalex.org/W2075293955', 'https://openalex.org/W2083799886', 'https://openalex.org/W2086554981', 'https://openalex.org/W2095011910', 'https://openalex.org/W2095358270', 'https://openalex.org/W2110252008', 'https://openalex.org/W2111650534', 'https://openalex.org/W2135475846', 'https://openalex.org/W2140946052', 'https://openalex.org/W2142911981', 'https://openalex.org/W2150756509', 'https://openalex.org/W2156179144', 'https://openalex.org/W2159583680', 'https://openalex.org/W2166041923', 'https://openalex.org/W2168985772', 'https://openalex.org/W2316070165', 'https://openalex.org/W2329201899', 'https://openalex.org/W4249339624'], 'related_works': ['https://openalex.org/W899441904', 'https://openalex.org/W2358998695', 'https://openalex.org/W2111512232', 'https://openalex.org/W2111507533', 'https://openalex.org/W2044252588', 'https://openalex.org/W2042949990', 'https://openalex.org/W2029377139', 'https://openalex.org/W2020987091', 'https://openalex.org/W1979154669', 'https://openalex.org/W1500396877'], 'abstract_inverted_index': {'Caspase-3': [0, 169, 1425], 'and': [1, 30, 36, 47, 69, 143, 162, 170, 199, 205, 216, 238, 312, 331, 349, 372, 428, 436, 447, 574, 644, 694, 745, 814, 836, 856, 919, 965, 1063, 1101, 1150, 1203, 1236, 1266, 1304, 1353, 1370, 1426, 1449, 1466, 1524, 1617, 1764, 1791, 1888, 1893, 1932, 2042, 2161, 2191, 2296, 2329, 2332, 2337, 2343, 2437, 2611, 2643, 2649, 2796, 2877, 2889, 2927, 3048, 3069, 3100, 3110, 3112, 3143, 3165, 3175, 3206, 3213, 3292, 3403, 3408, 3440, 3459, 3474, 3533, 3730, 3767, 3788, 3871, 3889, 3935, 3972, 4014], '-7': [2, 171, 448, 837, 857, 1237, 1371, 1427, 1894, 1933, 2162, 2210, 2333, 2344, 2512, 2778, 2815, 3214], 'are': [3, 112, 172, 281, 430, 838, 1231, 1468, 1752, 1966, 2000, 2198], 'considered': [4, 173], 'functionally': [5, 174, 1469], 'redundant': [6, 175, 1002], 'proteases': [7, 176], 'with': [8, 177, 841, 2515, 2623, 2781, 2818, 2899, 2969, 3015, 3108, 3173, 3393, 3427, 3455, 3468, 3476, 3808, 3945, 3982, 3999], 'similar': [9, 178, 872], 'proteolytic': [10, 179, 504, 2157, 2363, 3250], 'specificities.': [11, 180], 'We': [12, 181, 2015, 2317], 'performed': [13, 182, 3650], 'a': [14, 18, 57, 183, 187, 226, 339, 406, 541, 602, 876, 949, 976, 1433, 1627, 1650, 1684, 1870, 1896, 1978, 2164, 2294, 2392, 2492, 2543, 2770, 2782, 2803, 2819, 2838, 2895, 2949, 3023, 3051, 3072, 3115, 3178, 3325, 3357, 3503, 3753, 4000], 'proteome-wide': [15, 184], 'screen': [16, 185], 'on': [17, 157, 164, 186, 326, 333, 514, 1025, 1432, 1895, 2445, 2457, 2829, 3449], 'mouse': [19, 188, 2341, 2509, 3303, 3785, 3803, 3811], 'macrophage': [20, 189, 2165], 'lysate': [21, 190, 2952], 'using': [22, 191, 655, 2391, 2571, 2590, 2825, 2894, 3093, 3136, 3158, 3199, 3378, 3722, 3741, 3752], 'the': [23, 60, 65, 74, 77, 126, 130, 134, 192, 229, 234, 243, 246, 295, 299, 303, 438, 493, 503, 622, 691, 804, 842, 850, 994, 1026, 1030, 1099, 1169, 1179, 1224, 1302, 1378, 1594, 1622, 1647, 1687, 1835, 1845, 1860, 2005, 2019, 2205, 2462, 2466, 2568, 2577, 2604, 2614, 2826, 2862, 2878, 2913, 2928, 2956, 2963, 2981, 3016, 3089, 3094, 3125, 3137, 3155, 3159, 3188, 3200, 3224, 3333, 3371, 3438, 3463, 3723, 3742, 3758, 3768, 3946, 3956, 3983, 3997], 'N-terminal': [24, 193, 2021, 2052, 2081, 2129, 2243, 2597, 3230, 3543, 3572, 3620, 3686, 4029, 4034], 'combined': [25, 194, 1712, 2084, 3575], 'fractional': [26, 195, 897, 1713, 2085, 3576], 'diagonal': [27, 196, 898, 1714, 2086, 3577], 'chromatography': [28, 197, 1715, 2087, 3578], 'technology': [29, 198, 3135, 3198], 'identified': [31, 200, 1436, 2318, 3751], '46': [32, 201], 'shared,': [33, 202], 'three': [34, 203, 3410], 'caspase-3-specific,': [35, 204], 'six': [37, 206], 'caspase-7-specific': [38, 75, 116, 207, 244, 285], 'cleavage': [39, 45, 55, 136, 153, 208, 214, 224, 305, 322, 494, 642, 734, 864, 873, 1516, 1583, 1810, 1853, 1864, 1880, 1911, 1948, 1964, 2006, 2320, 2334, 2600, 2646], 'sites.': [40, 209, 2335], 'Further': [41, 210], 'analysis': [42, 211, 1817, 3512, 3648], 'of': [43, 73, 119, 128, 212, 242, 288, 297, 341, 409, 444, 454, 476, 492, 506, 517, 544, 605, 621, 649, 688, 690, 703, 747, 771, 807, 827, 853, 871, 878, 884, 952, 979, 1011, 1029, 1067, 1070, 1145, 1182, 1211, 1270, 1273, 1348, 1392, 1443, 1517, 1558, 1564, 1584, 1593, 1633, 1637, 1649, 1656, 1686, 1781, 1785, 1813, 1818, 1837, 1847, 1862, 1878, 1981, 2018, 2050, 2078, 2125, 2136, 2159, 2184, 2194, 2207, 2239, 2250, 2339, 2382, 2395, 2465, 2528, 2533, 2555, 2633, 2641, 2785, 2806, 2822, 2842, 2856, 2861, 2869, 2990, 3019, 3026, 3038, 3128, 3191, 3216, 3228, 3327, 3332, 3370, 3506, 3541, 3569, 3616, 3627, 3682, 3693, 3757, 3772, 3780, 3793, 3908, 4003, 4028, 4033, 4038], 'these': [44, 213, 507, 828, 997, 1012, 1848, 2885], 'sites': [46, 56, 215, 225, 1965, 2321], 'substitution': [48, 217], 'mutation': [49, 218], 'experiments': [50, 219], 'revealed': [51, 123, 220, 292, 1788], 'that': [52, 109, 124, 139, 221, 278, 293, 308, 831, 996, 1166, 2197], 'for': [53, 94, 115, 167, 222, 263, 284, 336, 700, 731, 834, 1178, 1403, 1590, 1653, 1755, 1816, 1891, 1908, 1945, 2494, 2539, 2917, 2939, 2974, 3006, 3033, 3078, 3362, 3367, 3417, 3431, 3490, 3829, 3951, 3955, 3988], 'certain': [54, 223], 'lysine': [58, 227], 'at': [59, 228, 2399, 2548, 2858, 2977, 3009, 3324, 3340, 3353, 3363, 3420, 3434, 3493, 3932, 3942, 3969, 3979], 'P5': [61, 230], 'position': [62, 231], 'contributes': [63, 232], 'to': [64, 148, 233, 317, 502, 600, 636, 848, 974, 1148, 1351, 1620, 1643, 1768, 1851, 1884, 1976, 2155, 2299, 2560, 2567, 2582, 2866, 2955, 3050, 3065, 3071, 3343, 3441, 3502, 3719, 3738, 3810, 3844, 4011, 4020], 'discrimination': [66, 235], 'between': [67, 236, 1377, 1930, 2794], 'caspase-7': [68, 102, 149, 155, 237, 271, 318, 324, 1175, 1227, 1467, 1520, 1616, 1654, 1682, 1741, 1787, 2648, 3481], '-3': [70, 239, 3484], 'specificity.': [71, 150, 240, 319], 'One': [72, 241], 'substrates,': [76, 245, 1438, 2325], '40': [78, 247], 'S': [79, 248], 'ribosomal': [80, 249], 'protein': [81, 250, 578, 2044, 2080, 2126, 2240, 2324, 2965, 2991, 3535, 3571, 3617, 3683, 3774, 3786, 3795, 3804, 3827, 3847, 3875], 'S18,': [82, 251], 'was': [83, 252, 651, 1882, 2385, 2443, 2454, 2513, 2536, 2558, 2565, 2580, 2601, 2779, 2816, 2847, 2985, 3084, 3106, 3130, 3150, 3171, 3193, 3346, 3499, 3649, 3930, 3940, 3967, 3977, 3994, 4009], 'studied': [84, 253], 'in': [85, 125, 254, 294, 368, 432, 576, 640, 858, 863, 868, 908, 1009, 1019, 1098, 1104, 1168, 1301, 1307, 1639, 1641, 1730, 1772, 1926, 2003, 2163, 2176, 2187, 2289, 2322, 2368, 2402, 2525, 2542, 2665, 2679, 2693, 2707, 2721, 2735, 2764, 2769, 2799, 2802, 2944, 2948, 2980, 3012, 3022, 3114, 3223, 3255, 3307, 3336, 3356, 3385, 3390, 3437, 3452, 3842, 3873], 'detail.': [86, 255], 'The': [87, 96, 256, 265, 404, 422, 472, 539, 618, 647, 825, 947, 2362, 2484, 2531, 2552, 2852, 2874, 2997, 3060, 3080, 3103, 3122, 3146, 3168, 3185, 3209, 3249, 3921], 'RPS18-derived': [88, 257], 'P6–P5′': [89, 258], 'undecapeptide': [90, 259], 'retained': [91, 260], 'complete': [92, 261, 3368], 'specificity': [93, 262, 643, 648, 832, 865, 1783, 1846], 'caspase-7.': [95, 168, 264, 337], 'corresponding': [97, 266, 2569], 'P6–P1': [98, 267], 'hexapeptide': [99, 268], 'still': [100, 269], 'displayed': [101, 270], 'preference': [103, 272], 'but': [104, 138, 273, 307, 631, 1635, 1759], 'lost': [105, 274], 'strict': [106, 275], 'specificity,': [107, 276], 'suggesting': [108, 277, 1245], 'P′': [110, 279], 'residues': [111, 132, 145, 280, 301, 314], 'additionally': [113, 282], 'required': [114, 283], 'cleavage.': [117, 286, 4006], 'Analysis': [118, 287, 2124, 2238, 3615, 3681], 'truncated': [120, 289], 'peptide': [121, 290, 721, 729, 749, 801, 844, 1849, 1898, 1906, 1927, 1943, 2022, 2188, 2520, 2588, 2645, 3714, 3814, 3936, 3952, 3964, 3973, 3989], 'mutants': [122, 291], 'case': [127, 296], 'RPS18': [129, 298, 3083, 3129], 'P4–P1': [131, 300], 'constitute': [133, 302], 'core': [135, 304], 'site': [137, 306, 1854, 2007, 2389], 'P6,': [140, 309], 'P5,': [141, 310], 'P2′,': [142, 311], 'P3′': [144, 313], 'critically': [146, 315], 'contribute': [147, 316], 'Interestingly,': [151, 320], 'specific': [152, 321, 1756, 1863], 'by': [154, 160, 323, 329, 351, 441, 654, 905, 1519, 1586, 1727, 1789, 1833, 2046, 2083, 2128, 2168, 2173, 2204, 2242, 2286, 2387, 2586, 2609, 2647, 2987, 3042, 3057, 3086, 3132, 3152, 3195, 3287, 3415, 3510, 3537, 3574, 3619, 3685, 3817], 'relies': [156, 325], 'excluding': [158, 327], 'recognition': [159, 328, 1928], 'caspase-3': [161, 330, 446, 835, 855, 1183, 1235, 1369, 1465, 1608, 1740, 1892, 1931, 2160, 2208, 2331, 2342, 2510, 2776, 2813, 3212], 'not': [163, 332, 628, 1636, 1960, 2451, 2506, 3347], 'increasing': [165, 334], 'binding': [166, 335], 'Caspases,': [338], 'family': [340, 693, 773, 1559], 'evolutionarily': [342], 'conserved': [343], 'proteases,': [344], 'mediate': [345], 'apoptosis,': [346], 'inflammation,': [347], 'proliferation,': [348], 'differentiation': [350], 'cleaving': [352], 'many': [353], 'cellular': [354, 1522, 3285], 'substrates': [355, 750, 802, 880, 1612, 1751, 1850, 2791], '(1Lamkanfi': [356], 'M.': [357, 670, 793, 795, 1116, 1130, 1319, 1333, 1659, 2028, 2115, 2229, 2282, 2351, 2477, 2483, 3238, 3274, 3519, 3606, 3672, 3897], 'Festjens': [358], 'N.': [359, 1189, 2108, 2222, 3599, 3665], 'Declercq': [360, 2352, 3239], 'W.': [361, 1132, 1335, 1543, 1551, 2353, 2359, 3240, 3246, 3280], 'Vanden': [362, 1665], 'Berghe': [363, 1666], 'T.': [364, 668, 764, 1138, 1341, 1667], 'Vandenabeele': [365, 1672, 2360, 2480, 3247, 3904], 'P.': [366, 559, 1093, 1296, 1664, 1673, 2067, 2099, 2213, 2361, 2481, 3248, 3276, 3558, 3590, 3656, 3856, 3895, 3905], 'Caspases': [367, 1061, 1264], 'cell': [369, 477, 909, 1731, 2177, 2290, 3290, 3295, 3380], 'survival,': [370], 'proliferation': [371], 'differentiation.Cell': [373], 'Death': [374, 390, 412, 525, 547, 608, 933, 955, 982, 1406, 1821, 1984, 2371, 3258], 'Differ.': [375, 391, 413, 526, 548, 609, 934, 956, 983, 1407, 1822, 1985, 2372, 3259], '2007;': [376, 392, 414, 483, 527, 549, 935, 957, 1529, 1570, 1795, 3913], '14:': [377, 393, 415, 528, 550, 936, 958], '44-55Crossref': [378], 'PubMed': [379, 395, 417, 463, 486, 530, 552, 587, 613, 715, 740, 785, 820, 938, 960, 987, 1075, 1110, 1159, 1218, 1278, 1313, 1362, 1411, 1479, 1537, 1573, 1601, 1700, 1798, 1826, 1917, 1954, 1989, 2058, 2092, 2150, 2264, 2312, 2376, 2500, 3263, 3549, 3583, 3641, 3707, 3835, 3884, 3916], 'Scopus': [380, 396, 418, 464, 487, 531, 553, 588, 614, 716, 741, 786, 821, 939, 961, 988, 1076, 1111, 1160, 1219, 1279, 1314, 1363, 1412, 1480, 1538, 1574, 1602, 1701, 1799, 1827, 1918, 1955, 1990, 2059, 2093, 2151, 2265, 2313, 2377, 2501, 3264, 3550, 3584, 3642, 3708, 3836, 3885, 3917], '(459)': [381], 'Google': [382, 398, 420, 466, 489, 533, 555, 590, 616, 718, 743, 788, 823, 941, 963, 990, 1078, 1113, 1162, 1221, 1281, 1316, 1365, 1414, 1482, 1540, 1576, 1604, 1703, 1801, 1829, 1920, 1957, 1992, 2061, 2095, 2153, 2267, 2315, 2379, 2503, 3266, 3301, 3552, 3586, 3644, 3710, 3838, 3887, 3919], 'Scholar,': [383, 399, 467, 534, 556, 591, 789, 942, 964, 1079, 1114, 1282, 1317, 1483, 1541, 1577, 1802, 2062, 2096, 2268, 3553, 3587], '2Timmer': [384, 927], 'J.C.': [385, 520, 928], 'Salvesen': [386, 451, 470, 521, 796, 929, 1805], 'G.S.': [387, 452, 471, 522, 797, 930, 1122, 1325, 1806], 'Caspase': [388, 523, 931], 'substrates.Cell': [389, 411, 524, 546, 607, 932, 954, 981, 1983], '66-72Crossref': [394, 529, 937], '(333)': [397, 532, 940], '3Lüthi': [400, 535, 943], 'A.U.': [401, 536, 944, 1459], 'Martin': [402, 537, 945, 1462], 'S.J.': [403, 469, 538, 946, 1463], 'CASBAH:': [405, 540, 948], 'searchable': [407, 542, 950], 'database': [408, 543, 951, 3760], 'caspase': [410, 455, 545, 606, 692, 772, 953, 980, 1146, 1349, 1396, 1757, 1963, 1982, 2562, 2961], '641-650Crossref': [416, 551, 959], '(345)': [419, 554, 962], 'Scholar).': [421, 490, 617, 824, 991, 1163, 1222, 1366, 1605, 1704, 1830, 1921, 1958, 2316, 2380, 3267, 3645, 3711, 3920], 'apoptotic': [423, 1819], 'initiator': [424], 'caspases': [425, 626, 650, 809, 999, 1013, 1771, 2384, 3021], '(caspase-8,': [426], '-9,': [427], '-10)': [429], 'activated': [431], 'large': [433], 'signaling': [434], 'platforms': [435], 'propagate': [437], 'death': [439], 'signal': [440], 'cleavage-induced': [442], 'activation': [443, 1592, 1632, 2365, 3252], 'executioner': [445, 509, 625, 1624, 1786], '(4Boatright': [449], 'K.M.': [450], 'Mechanisms': [453], 'activation.Curr.': [456], 'Opin.': [457], 'Cell': [458, 481, 3349], 'Biol.': [459, 482, 705, 775, 1527], '2003;': [460, 610, 984, 1986, 2055, 3546], '15:': [461, 1824], '725-731Crossref': [462], '(1084)': [465], '5Riedl': [468], 'apoptosome:': [473], 'signalling': [474], 'platform': [475], 'death.Nat.': [478], 'Rev.': [479], 'Mol.': [480], '8:': [484, 2090, 2143, 2257, 3581, 3634, 3700], '405-413Crossref': [485], '(861)': [488], 'Most': [491], 'events': [495, 1069, 1272, 2158, 3849], 'occurring': [496], 'during': [497, 580, 1004, 1423, 1613, 3877], 'apoptosis': [498, 1097, 1149, 1300, 1352, 1444, 1614], 'have': [499, 627, 1000, 1021, 1418, 1858, 2345], 'been': [500, 629, 2346], 'attributed': [501], 'activity': [505, 852, 2442, 2870], 'two': [508, 623, 998], 'caspases,': [510], 'which': [511, 1856, 2180, 3341, 3781], 'can': [512], 'act': [513], 'several': [515], 'hundreds': [516], 'proteins': [518, 3000], '(2Timmer': [519], '6Van': [557, 3854], 'Damme': [558, 563, 1663, 2032, 2066, 2098, 2212, 3523, 3557, 3589, 3655, 3855, 3860, 3894], 'Martens': [560, 2029, 3520, 3857], 'L.': [561, 1487, 2030, 3521, 3820, 3858, 3892], 'Van': [562, 1662, 2031, 2065, 2104, 2218, 2354, 3241, 3522, 3556, 3595, 3661, 3859, 3893], 'J.': [564, 570, 816, 1388, 1493, 1671, 1775, 1794, 2033, 2039, 2073, 2106, 2119, 2121, 2220, 2233, 2235, 3282, 3524, 3530, 3564, 3597, 3610, 3612, 3663, 3676, 3678, 3822, 3861, 3867, 3901], 'Hugelier': [565, 3862], 'K.': [566, 572, 597, 971, 1049, 1081, 1252, 1284, 1675, 1973, 2026, 2069, 2075, 2103, 2123, 2217, 2237, 3517, 3560, 3566, 3594, 3614, 3660, 3680, 3824, 3863, 3869, 3903], 'Staes': [567, 2034, 3525, 3864], 'A.': [568, 1047, 1124, 1128, 1250, 1327, 1331, 1495, 1499, 2035, 2064, 2280, 3526, 3555, 3865], 'Vandekerckhove': [569, 1670, 2038, 2072, 2120, 2234, 3529, 3563, 3611, 3677, 3821, 3866, 3900], 'Gevaert': [571, 1674, 2074, 2122, 2236, 3565, 3613, 3679, 3823, 3868, 3902], 'Caspase-specific': [573, 3870], 'nonspecific': [575, 3872], 'vivo': [577, 3874], 'processing': [579, 2045, 2127, 2241, 3536, 3618, 3684, 3826, 3848, 3876], 'Fas-induced': [581, 3878], 'apoptosis.Nat.': [582, 3879], 'Methods.': [583, 3880], '2005;': [584, 3832, 3881], '2:': [585, 3882], '771-777Crossref': [586, 3883], '(206)': [589, 3886], '7Fischer': [592, 966], 'U.': [593, 967, 1969], 'Jänicke': [594, 968, 1970], 'R.U.': [595, 969, 1971], 'Schulze-Osthoff': [596, 970, 1972], 'Many': [598, 972, 1974], 'cuts': [599, 973, 1975], 'ruin:': [601, 975, 1977], 'comprehensive': [603, 977, 1979], 'update': [604, 978, 1980], '10:': [611, 985, 1987], '76-100Crossref': [612, 986, 1988], '(891)': [615, 989, 1991], 'substrate': [619, 1421, 1562, 1685, 2134, 2248, 2493, 2863, 2872, 3625, 3691], 'degradomes': [620], 'main': [624], 'determined': [630, 2386, 2883, 2898], 'their': [632, 641, 869, 3217], 'identification': [633, 1557, 1861, 1877, 2049, 3540, 3907], 'is': [634, 866, 1588, 2491], 'important': [635], 'gaining': [637], 'greater': [638], 'insight': [639], 'biological': [645, 859], 'functions.': [646], 'rigorously': [652], 'profiled': [653], 'combinatorial': [656, 684], 'tetrapeptide': [657, 1750], 'libraries': [658, 722, 730, 1907, 1944], '(8Thornberry': [659], 'N.A.': [660], 'Rano': [661], 'T.A.': [662], 'Peterson': [663], 'E.P.': [664], 'Rasper': [665, 1190], 'D.M.': [666], 'Timkey': [667], 'Garcia-Calvo': [669], 'Houtzager': [671], 'V.M.': [672], 'Nordstrom': [673], 'P.A.': [674], 'Roy': [675, 1194], 'S.': [676, 756, 1085, 1195, 1288, 1489, 1503, 2101, 2215, 3592, 3658], 'Vaillancourt': [677], 'J.P.': [678], 'Chapman': [679], 'K.T.': [680], 'Nicholson': [681, 1198], 'D.W.': [682, 1199], 'A': [683], 'approach': [685, 2298], 'defines': [686], 'specificities': [687, 770, 1422], 'members': [689], 'granzyme': [695, 2137, 2251, 3628, 3694], 'B.': [696, 1553, 1777, 2272], 'Functional': [697], 'relationships': [698], 'established': [699], 'key': [701, 1065, 1268], 'mediators': [702, 1066, 1269], 'apoptosis.J.': [704], 'Chem.': [706, 776, 1528], '1997;': [707, 777], '272:': [708, 778], '17907-17911Abstract': [709], 'Full': [710, 712, 780, 782, 1532, 1534, 1695, 1697, 2145, 2147, 2259, 2261, 2307, 2309, 3636, 3638, 3702, 3704], 'Text': [711, 713, 781, 783, 1533, 1535, 1696, 1698, 2146, 2148, 2260, 2262, 2308, 2310, 3637, 3639, 3703, 3705], 'PDF': [714, 784, 1536, 1699, 2149, 2263, 2311, 3640, 3706], '(1852)': [717], 'Scholar),': [719, 744, 1415, 1993], 'proteome-derived': [720], '(9Schilling': [723, 1900, 1937], 'O.': [724, 1901, 1938], 'Overall': [725, 1902, 1939], 'C.M.': [726, 1903, 1940], 'Proteome-derived,': [727, 1904, 1941], 'database-searchable': [728, 1905, 1942], 'identifying': [732, 1909, 1946], 'protease': [733, 1879, 1910, 1947], 'sites.Nat.': [735, 1912, 1949], 'Biotechnol.': [736, 1913, 1950, 2054, 3545], '2008;': [737, 1476, 1598, 1692, 1823, 1914, 1951, 2089, 3580], '26:': [738, 1915, 1952], '685-694Crossref': [739, 1916, 1953], '(320)': [742, 1919, 1956], 'sets': [746], 'individual': [748, 1770], '(10Talanian': [751], 'R.V.': [752], 'Quinlan': [753], 'C.': [754, 1087, 1185, 1290, 1457, 1461], 'Trautz': [755], 'Hackett': [757], 'M.C.': [758], 'Mankovich': [759], 'J.A.': [760], 'Banach': [761], 'D.': [762, 1089, 1126, 1191, 1292, 1329], 'Ghayur': [763], 'Brady': [765], 'K.D.': [766], 'Wong': [767], 'W.W.': [768], 'Substrate': [769], 'proteases.J.': [774], '9677-9682Abstract': [779], '(776)': [787], '11Stennicke': [790], 'H.R.': [791], 'Renatus': [792], 'Meldal': [794], 'Internally': [798], 'quenched': [799], 'fluorescent': [800], 'disclose': [803], 'subsite': [805], 'preferences': [806, 1890], 'human': [808], '1,': [810], '3,': [811], '6,': [812], '7': [813], '8.Biochem.': [815], '2000;': [817, 2497], '350:': [818], '563-568Crossref': [819], '(264)': [822], 'results': [826], 'studies': [829], 'indicate': [830], 'motifs': [833, 1929], 'nearly': [839], 'indistinguishable': [840], 'canonical': [843], 'substrate,': [845], 'DEVD,': [846], 'used': [847, 892, 1754, 1767, 1883, 2559, 2865, 2936], 'monitor': [849, 1769], 'enzymatic': [851], 'both': [854, 1886, 2383], 'samples.': [860], 'This': [861, 992, 1164], 'overlap': [862, 3133, 3196], 'manifested': [867], 'generation': [870, 2532, 2557], 'fragments': [874], 'from': [875, 1374, 1397, 2603, 2884, 2912, 3088, 3154, 3784], 'variety': [877], 'apoptosis-related': [879], 'such': [881, 1172, 1840, 2013], 'as': [882, 1016, 1173, 1242, 1683, 1841, 2293, 2447, 2469, 2849, 2937, 3233, 3513, 3651, 3948, 3985, 3996], 'inhibitor': [883, 1442], 'caspase-activated': [885], 'DNase,': [886], 'keratin': [887], '18,': [888], 'PARP,': [889], '1The': [890], 'abbreviations': [891], 'are:PARPpoly(ADP-ribose)': [893], 'polymeraseamc7-amino-4-methylcoumarineAbz2-amino-benzoic': [894], 'acidCFScell-free': [895], 'systemCOFRADICcombined': [896], 'chromatographyIAAiodoacetamidekcatcatalytic': [899], 'constantKmMichaelis-Menten': [900], 'constantY(NO2)3-nitrotyrosineRPreverse': [901], 'phaseSILACstable': [902], 'isotope': [903, 1725, 2171, 2284], 'labeling': [904, 1726, 2172, 2285], 'amino': [906, 1728, 2174, 2287], 'acids': [907, 1729, 2175, 2288], 'culturezVAD-fmkbenzyloxycarbonyl-valine-alanine-aspartic': [910], 'acid(OMe)fluoromethyl': [911, 1734], 'ketonepNAp-nitroanilideFmocN-(9-fluorenyl)methoxycarbonylwtwild': [912], 'typeC3caspase-3C7caspase-7HDGFhepatoma-derived': [913], 'growth': [914, 1743], 'factorOtButert-butyl': [915], 'ester.': [916, 1746], 'protein-disulfide': [917], 'isomerase,': [918], 'Rho': [920], 'kinase': [921], 'I': [922], '(for': [923], 'reviews,': [924], 'see': [925], 'Refs.': [926, 3853], 'propagated': [993], 'view': [995], 'completely': [1001], 'functions': [1003], 'apoptosis.': [1005], 'Surprisingly,': [1006], 'mice': [1007, 1017, 1033, 1230, 1240], 'deficient': [1008, 1018, 1229, 1239], 'one': [1010, 4004], '(as': [1014], 'well': [1015], 'both)': [1020], 'distinct': [1022, 1470], 'phenotypes.': [1023], 'Depending': [1024], 'genetic': [1027, 1170], 'background': [1028], 'mice,': [1031], 'caspase-3-deficient': [1032], 'either': [1034, 3314, 3477], 'die': [1035, 1241], 'before': [1036, 3653], 'birth': [1037], '(129/SvJ)': [1038], 'or': [1039, 1995, 2201, 2209, 2511, 2625, 2777, 2787, 2814, 2845, 3045, 3317, 3483, 3486], 'develop': [1040], 'almost': [1041], 'normally': [1042], '(C57BL/6J)': [1043], '(12Lakhani': [1044, 1247], 'S.A.': [1045, 1134, 1248, 1337], 'Masud': [1046, 1249], 'Kuida': [1048, 1251], 'Porter': [1050, 1253], 'Jr.,': [1051, 1254], 'G.A.': [1052, 1255], 'Booth': [1053, 1256], 'C.J.': [1054, 1257], 'Mehal': [1055, 1258], 'W.Z.': [1056, 1259], 'Inayat': [1057, 1260], 'I.': [1058, 1261, 1669, 2274, 2357, 3244], 'Flavell': [1059, 1094, 1262, 1297], 'R.A.': [1060, 1095, 1263, 1298], '3': [1062, 1265], '7:': [1064, 1267, 1693], 'mitochondrial': [1068, 1271], 'apoptosis.Science.': [1071, 1274], '2006;': [1072, 1275], '311:': [1073, 1276], '847-851Crossref': [1074, 1277], '(923)': [1077, 1280], '13Kuida': [1080, 1283], 'Zheng': [1082, 1285], 'T.S.': [1083, 1286], 'Na': [1084, 1287], 'Kuan': [1086, 1289], 'Yang': [1088, 1291], 'Karasuyama': [1090, 1293], 'H.': [1091, 1294, 1547, 2071, 2278, 3278, 3562], 'Rakic': [1092, 1295], 'Decreased': [1096, 1299], 'brain': [1100, 1209, 1303], 'premature': [1102, 1305], 'lethality': [1103, 1306], 'CPP32-deficient': [1105, 1308], 'mice.Nature.': [1106, 1309], '1996;': [1107, 1310], '384:': [1108, 1311], '368-372Crossref': [1109, 1312], '(1713)': [1112, 1315], '14Woo': [1115, 1318], 'Hakem': [1117, 1127, 1320, 1330], 'R.': [1118, 1321, 1507, 1555], 'Soengas': [1119, 1322], 'M.S.': [1120, 1323], 'Duncan': [1121, 1324], 'Shahinian': [1123, 1326], 'Kägi': [1125, 1328], 'McCurrach': [1129, 1332], 'Khoo': [1131, 1334], 'Kaufman': [1133, 1336], 'Senaldi': [1135, 1338], 'G.': [1136, 1339, 1677], 'Howard': [1137, 1340], 'Lowe': [1139, 1342], 'S.W.': [1140, 1343], 'Mak': [1141, 1344], 'T.W.': [1142, 1345], 'Essential': [1143, 1346], 'contribution': [1144, 1347], '3/CPP32': [1147, 1350], 'its': [1151, 1354], 'associated': [1152, 1355], 'nuclear': [1153, 1356], 'changes.Genes': [1154, 1357], 'Dev.': [1155, 1358], '1998;': [1156, 1359, 3298], '12:': [1157, 1360], '806-819Crossref': [1158, 1361], '(768)': [1161, 1364], 'suggests': [1165], 'dynamics': [1167], 'background,': [1171, 1226], 'increased': [1174], 'expression,': [1176], 'compensate': [1177], 'functional': [1180], 'loss': [1181], '(15Houde': [1184], 'Banks': [1186], 'K.G.': [1187], 'Coulombe': [1188], 'Grimm': [1192], 'E.': [1193, 1386, 1497, 2110, 2224, 3601, 3667], 'Simpson': [1196], 'E.M.': [1197], 'Caspase-7': [1200], 'expanded': [1201], 'function': [1202, 1652], 'intrinsic': [1204], 'expression': [1205, 2300], 'level': [1206], 'underlies': [1207], 'strain-specific': [1208], 'phenotype': [1210], 'caspase-3-null': [1212], 'mice.J.': [1213], 'Neurosci.': [1214], '2004;': [1215], '24:': [1216], '9977-9984Crossref': [1217], '(81)': [1220], 'In': [1223, 1606], 'C57BL/6J': [1225], 'single': [1228], 'also': [1232, 2455], 'viable,': [1233], 'whereas': [1234], 'double': [1238], 'embryos,': [1243], 'further': [1244], 'redundancy': [1246], 'However,': [1367, 1922], 'because': [1368], 'probably': [1372], 'arose': [1373], 'gene': [1375], 'duplication': [1376], 'Cephalochordata-Vertebrata': [1379], 'diversion': [1380], '(16Bayascas': [1381], 'J.R.': [1382], 'Yuste': [1383], 'V.J.': [1384], 'Benito': [1385], 'Garcia-Fernàndez': [1387], 'Comella': [1389], 'J.X.': [1390], 'Isolation': [1391], 'AmphiCASP-3/7,': [1393], 'an': [1394, 2367, 2591, 2830, 3229, 3254], 'ancestral': [1395], 'amphioxus': [1398], '(Branchiostoma': [1399], 'floridae).': [1400], 'Evolutionary': [1401], 'considerations': [1402], 'vertebrate': [1404], 'caspases.Cell': [1405], '2002;': [1408, 2304], '9:': [1409], '1078-1089Crossref': [1410], '(36)': [1413], 'they': [1416, 1760, 3445], 'might': [1417], 'acquired': [1419], 'different': [1420, 1430], 'evolution.': [1424], 'do': [1428], 'exhibit': [1429], 'activities': [1431], 'few': [1434], 'arbitrarily': [1435], 'natural': [1437, 1561], 'including': [1439], 'BID,': [1440], 'X-linked': [1441], 'protein,': [1445], 'gelsolin,': [1446], 'caspase-6,': [1447], 'ataxin-7,': [1448], 'co-chaperone': [1450], 'p23': [1451], '(17Walsh': [1452], 'J.G.': [1453], 'Cullen': [1454], 'S.P.': [1455], 'Sheridan': [1456], 'Lüthi': [1458], 'Gerner': [1460], 'Executioner': [1464], 'proteases.Proc.': [1471], 'Natl.': [1472, 1566], 'Acad.': [1473, 1567], 'Sci.': [1474, 1568], 'U.S.A.': [1475, 1569], '105:': [1477], '12815-12819Crossref': [1478], '(415)': [1481], '18Young': [1484], 'J.E.': [1485], 'Gouw': [1486], 'Propp': [1488], 'Sopher': [1490], 'B.L.': [1491], 'Taylor': [1492], 'Lin': [1494], 'Hermel': [1496], 'Logvinova': [1498], 'Chen': [1500, 1502], 'S.F.': [1501], 'Bredesen': [1504], 'D.E.': [1505], 'Truant': [1506], 'Ptacek': [1508], 'L.J.': [1509], 'La': [1510], 'Spada': [1511], 'A.R.': [1512], 'Ellerby': [1513], 'L.M.': [1514], 'Proteolytic': [1515, 2441], 'ataxin-7': [1518], 'modulates': [1521], 'toxicity': [1523], 'transcriptional': [1525], 'dysregulation.J.': [1526], '282:': [1530], '30150-30160Abstract': [1531], '(69)': [1539], '19Ju': [1542], 'Valencia': [1544], 'C.A.': [1545], 'Pang': [1546], 'Ke': [1548], 'Y.': [1549], 'Gao': [1550], 'Dong': [1552], 'Liu': [1554], 'Proteome-wide': [1556, 3906], 'member-specific': [1560], 'repertoire': [1563], 'caspases.Proc.': [1565], '104:': [1571], '14294-14299Crossref': [1572], '(45)': [1575], '20Song': [1578], 'J.J.': [1579], 'Lee': [1580], 'Y.J.': [1581], 'Differential': [1582], 'Mst1': [1585], 'caspase-7/-3': [1587], 'responsible': [1589], 'TRAIL-induced': [1591], 'MAPK': [1595], 'superfamily.Cell.': [1596], 'Signal.': [1597], '20:': [1599], '892-906Crossref': [1600], '(59)': [1603], 'addition,': [1607], 'generally': [1609, 2011], 'cleaves': [1610], 'more': [1611, 3850], 'than': [1615], 'therefore': [1618], 'appears': [1619], 'be': [1621, 1766, 1935], 'major': [1623], 'caspase.': [1625], 'Moreover,': [1626], 'recent': [1628], 'report': [1629], 'describing': [1630], 'caspase-1-dependent': [1631], 'caspase-7,': [1634], 'caspase-3,': [1638], 'macrophages': [1640, 3304], 'response': [1642], 'microbial': [1644], 'stimuli': [1645], 'supports': [1646], 'idea': [1648], 'non-redundant': [1651], 'downstream': [1655, 3227, 3511], 'caspase-1': [1657, 1688], '(21Lamkanfi': [1658], 'Kanneganti': [1660], 'T.D.': [1661], 'Vanoverberghe': [1668], 'Núñez': [1676], 'Targeted': [1678], 'peptidecentric': [1679], 'proteomics': [1680, 1873, 2130, 2244, 3621, 3687], 'reveals': [1681, 2131, 2245, 3622, 3688], 'inflammasomes.Mol.': [1689], 'Cell.': [1690, 2140, 2254, 2302, 3631, 3697], 'Proteomics.': [1691, 2141, 2255, 2303, 3632, 3698], '2350-2363Abstract': [1694], '(244)': [1702], 'poly(ADP-ribose)': [1705], 'polymerase': [1706], '7-amino-4-methylcoumarine': [1707], '2-amino-benzoic': [1708], 'acid': [1709], 'cell-free': [1710, 2403], 'system': [1711, 2404, 2953], 'iodoacetamide': [1716, 2972, 3430], 'catalytic': [1717, 2879], 'constant': [1718, 1720, 2880], 'Michaelis-Menten': [1719, 2875], '3-nitrotyrosine': [1721, 2839], 'reverse': [1722], 'phase': [1723], 'stable': [1724, 2170], 'culture': [1732, 2178], 'benzyloxycarbonyl-valine-alanine-aspartic': [1733], 'ketone': [1735], 'p-nitroanilide': [1736], 'N-(9-fluorenyl)methoxycarbonyl': [1737], 'wild': [1738], 'type': [1739], 'hepatoma-derived': [1742], 'factor': [1744], 'tert-butyl': [1745], 'Commercially': [1747], 'available': [1748], '"caspase-specific"': [1749], 'widely': [1753], 'detection,': [1758], 'display': [1761], 'substantial': [1762], 'promiscuity': [1763], 'cannot': [1765], 'cells': [1773, 3375], '(22Agniswamy': [1774], 'Fang': [1776], 'Weber': [1778], 'I.T.': [1779], 'Plasticity': [1780], 'S2-S4': [1782], 'pockets': [1784], 'structural': [1790, 1994], 'kinetic': [1792, 2619], 'analysis.FEBS': [1793], '274:': [1796], '4752-4765Crossref': [1797], '(47)': [1800], '23McStay': [1803], 'G.P.': [1804], 'Green': [1807], 'D.R.': [1808], 'Overlapping': [1809], 'motif': [1811], 'selectivity': [1812], 'caspases:': [1814], 'implications': [1815], 'pathways.Cell': [1820], '322-331Crossref': [1825], '(258)': [1828], 'Detecting': [1831], 'proteolysis': [1832], 'measuring': [1834], 'release': [1836], 'C-terminal': [1838, 2615], 'fluorophores,': [1839], '7-amino-4-methylcoumarin': [1842], '(amc),': [1843], 'restricts': [1844], 'non-prime': [1852, 1887], 'residues,': [1855], 'may': [1857], 'hampered': [1859], 'events.': [1865], 'To': [1866], 'address': [1867], 'this': [1868], 'limitation,': [1869], 'recently': [1871], 'developed': [1872], 'technique,': [1874], 'called': [1875], 'proteomic': [1876], 'sites,': [1881], 'map': [1885], 'prime': [1889], 'tryptic': [1897], 'library': [1899], 'no': [1923], 'clear': [1924], 'distinction': [1925], 'could': [1934], 'observed': [1936], 'Because': [1959], 'all': [1961, 2859], 'classical': [1962], 'processed': [1967], '(7Fischer': [1968], 'post-translational': [1996], 'higher': [1997], 'order': [1998], 'constraints': [1999], 'likely': [2001], 'involved': [2002], 'steering': [2004], 'selectivity.': [2008], 'Peptide-based': [2009], 'approaches': [2010], 'overlook': [2012], 'aspects.': [2014], 'made': [2016, 2635, 3816], 'use': [2017, 2989], 'COFRADIC': [2020], 'sorting': [2023], 'methodology': [2024], '(24Gevaert': [2025, 3516], 'Goethals': [2027, 2114, 2228, 3518, 3605, 3671], 'Thomas': [2036, 3527], 'G.R.': [2037, 3528], 'Exploring': [2040, 3531], 'proteomes': [2041, 3532], 'analyzing': [2043, 3534], 'mass': [2047, 3538, 3928, 3938, 3965, 3975], 'spectrometric': [2048, 3539], 'sorted': [2051, 3542], 'peptides.Nat.': [2053, 3544], '21:': [2056, 3547, 3833], '566-569Crossref': [2057, 3548], '(508)': [2060, 3551], '25Staes': [2063, 3554], 'Helsens': [2068, 3559], 'Demol': [2070, 3561], 'Improved': [2076, 3567], 'recovery': [2077, 3568], 'proteome-informative,': [2079, 3570], 'peptides': [2082, 2636, 3573], '(COFRADIC).Proteomics.': [2088, 3579], '1362-1370Crossref': [2091, 3582], '(129)': [2094, 3585], '26Van': [2097, 3588], 'Maurer-Stroh': [2100, 2214, 3591, 3657], 'Plasman': [2102, 2216, 3593, 3659], 'Durme': [2105, 2219, 3596, 3662], 'Colaert': [2107, 2221, 3598, 3664], 'Timmerman': [2109, 2223, 3600, 3666], 'De': [2111, 2225, 3602, 3668], 'Bock': [2112, 2226, 3603, 3669], 'P.J.': [2113, 2227, 3604, 3670], 'Rousseau': [2116, 2230, 3607, 3673], 'F.': [2117, 2231, 3608, 3674], 'Schymkowitz': [2118, 2232, 3609, 3675], 'novel': [2132, 2246, 3623, 3689], 'species-specific': [2133, 2247, 3624, 3690], 'determinants': [2135, 2249, 3626, 3692], 'B': [2138, 2252, 3629, 3695], 'orthologs.Mol.': [2139, 2253, 3630, 3696], '2009;': [2142, 2256, 3633, 3699], '258-272Abstract': [2144, 2258, 3635, 3701], '(95)': [2152, 2266, 3643, 3709], 'Scholar)': [2154, 2504, 3302, 3839], 'profile': [2156], 'proteome': [2166], 'labeled': [2167, 2616, 3372], 'triple': [2169], '(SILAC),': [2179], 'allowed': [2181], 'direct': [2182], 'comparison': [2183], 'peak': [2185], 'intensities': [2186], 'MS': [2189], 'spectra': [2190, 3716, 3735], 'consequent': [2192], 'quantification': [2193], 'N': [2195], 'termini': [2196], 'equally,': [2199], 'preferably,': [2200], 'exclusively': [2202], 'generated': [2203, 3131, 3194], 'action': [2206], '(26Van': [2211, 3654], '27Ong': [2269], 'S.E.': [2270], 'Blagoev': [2271], 'Kratchmarova': [2273], 'Kristensen': [2275], 'D.B.': [2276], 'Steen': [2277], 'Pandey': [2279], 'Mann': [2281], 'Stable': [2283], 'culture,': [2291], 'SILAC,': [2292], 'simple': [2295], 'accurate': [2297], 'proteomics.Mol.': [2301], '1:': [2305], '376-386Abstract': [2306], '(4625)': [2314], '55': [2319], '48': [2323], 'encompassing': [2326], 'mutual,': [2327], 'preferred,': [2328], 'unique': [2330], 'Expression': [2336], 'purification': [2338, 2608], 'recombinant': [2340, 2775, 2812, 3020, 3480], 'described': [2347, 2448, 2470, 2850, 2932, 3234, 3514, 3652], '(28Van': [2348, 3235], 'de': [2349, 2475, 3236], 'Craen': [2350, 2476, 3237], 'den': [2355, 3242], 'brande': [2356, 3243], 'Fiers': [2358, 3245, 3279], 'procaspase': [2364, 3251], 'network:': [2366, 3253], 'vitro': [2369, 2945, 3256], 'analysis.Cell': [2370, 3257], '1999;': [2373, 3260], '6:': [2374, 3261, 3914], '1117-1124Crossref': [2375, 3262], '(175)': [2378, 3265], 'Activity': [2381, 2453], 'active': [2388], 'titration': [2390], 'serial': [2393, 2783, 2820], 'dilution': [2394, 2784, 2821], 'zVAD-fmk': [2396], '(25': [2397], 'min': [2398, 2541, 2976, 3035, 3419, 3433], '37': [2400, 3010, 3354, 3494], '°C)': [2401], '(CFS)': [2405], 'buffer': [2406, 2801, 3014, 3382], 'containing': [2407, 3313, 3776, 3797], '220': [2408], 'mm': [2409, 2412, 2415, 2418, 2421, 2426, 2439, 2971, 3405, 3429, 3471], 'mannitol,': [2410], '170': [2411], 'sucrose,': [2413], '5': [2414, 2417, 2970, 3428], 'NaCl,': [2416], 'MgCl2,': [2419], '10': [2420, 2438, 3034], 'HEPES,': [2422], 'pH': [2423], '7.5,': [2424], '2.5': [2425], 'KH2PO4,': [2427], '2.1': [2428, 3394, 3764], 'µm': [2429, 2432, 2435, 2517, 3329, 3395, 3398, 3401], 'leupeptin,': [2430, 3396, 3456], '0.15': [2431, 3397], 'aprotinin,': [2433, 3399, 3457], '100': [2434, 2516, 2810, 3400], 'PMSF,': [2436, 3402, 3458], 'DTT.': [2440], 'quantified': [2444, 2456], 'Ac-DEVD-amc': [2446, 2519], 'below': [2449], '(data': [2450, 2505], 'shown).': [2452, 2507], 'proendothelial': [2458], 'monocyte-activating': [2459, 2486], 'polypeptide': [2460, 2487], 'II,': [2461], 'p43': [2463], 'component': [2464], 'aminoacyl-tRNA': [2467], 'complex': [2468], 'previously': [2471, 3515], '(29Behrensdorf': [2472], 'H.A.': [2473], 'van': [2474], 'Knies': [2478], 'U.E.': [2479], 'Clauss': [2482], 'endothelial': [2485], 'II': [2488], '(EMAP': [2489], 'II)': [2490], 'caspase-7.FEBS': [2495], 'Lett.': [2496], '466:': [2498], '143-147Crossref': [2499], '(67)': [2502], 'Recombinant': [2508], 'incubated': [2514, 2780, 2817, 3005, 3475], 'fluorogenic': [2518, 2789], '(Peptide': [2521], 'Institute,': [2522], 'Osaka,': [2523], 'Japan)': [2524], '150': [2526], 'µl': [2527], 'CFS': [2529, 2800, 3013], 'buffer.': [2530], 'free': [2534, 2843, 2900], 'amc': [2535, 2844], 'continuously': [2537], 'monitored': [2538, 2848], '50': [2540, 2773], 'fluorometer': [2544], '(CytoFluor,': [2545], 'PerSeptive': [2546], 'Biosystems)': [2547], '360/460-nm': [2549], 'excitation/emission': [2550], 'wavelengths.': [2551], 'linear': [2553, 2854], 'rate': [2554], 'fluorophore': [2556], 'quantify': [2561], 'activity.': [2563], 'Fmoc-Asp(OtBu)-OH': [2564], 'converted': [2566, 3718, 3737], 'amide': [2570], 'amc.': [2572, 2901], 'After': [2573], 'side': [2574], 'chain': [2575], 'deprotection,': [2576], 'Fmoc-Asp-amc': [2578], 'residue': [2579], 'attached': [2581], '2-chlorotrityl': [2583], 'resin': [2584], 'followed': [2585, 3509], 'automated': [2587], 'synthesis': [2589], 'O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium': [2592], 'hexafluorophosphate/diisopropylethylamine': [2593], 'protocol.': [2594], 'Subsequently,': [2595, 3462], 'following': [2596, 3095, 3138, 3160, 3201, 3922], 'acetylation,': [2598], 'acidic': [2599], 'done': [2602], 'solid': [2605], 'support.': [2606], 'Finally,': [2607], 'precipitation': [2610], 'lyophilization': [2612], 'yielded': [2613], 'Ac-peptide-amc.': [2617], 'Identical': [2618], 'values': [2620, 2891], 'were': [2621, 2864, 2882, 2892, 2935, 2967, 3003, 3031, 3063, 3221, 3270, 3305, 3351, 3376, 3413, 3425, 3446, 3466, 3717, 3736, 3750, 3806, 3840, 3925, 4018], 'obtained': [2622], 'commercial': [2624], 'in-house': [2626, 2634], 'synthesized': [2627], 'Ac-DEVD-amc,': [2628], 'illustrating': [2629], 'sufficiently': [2630], 'high': [2631], 'quality': [2632], '(Table': [2637], 'I).Table': [2638], 'IKinetic': [2639], 'parameters': [2640, 3924], 'DEVD-': [2642, 2786], 'DVKD-based': [2644, 2788], '-3SubstratekcatKmkcat/KmC7C3C7C3C7C3s−1µmm−1': [2650], 's−1DEVDaCommercial': [2651], 'source.0.17': [2652], '±': [2653, 2655, 2657, 2659, 2661, 2663, 2667, 2669, 2671, 2673, 2675, 2677, 2681, 2683, 2685, 2687, 2689, 2691, 2695, 2697, 2699, 2701, 2703, 2705, 2709, 2711, 2713, 2715, 2717, 2719, 2723, 2725, 2727, 2729, 2731, 2733, 2737, 2739, 2741, 2743, 2745, 2747, 2749, 2751, 2753, 2755, 2757, 2759], '0.008.32': [2654], '0.329.0': [2656], '0.6108': [2658], '1418,900': [2660], '1,28076,500': [2662], '10,800DEVDbSynthesized': [2664], 'house.0.14': [2666], '0.008.39': [2668], '0.477.9': [2670], '0.6112': [2672], '1117,800': [2674], '1,38074,700': [2676], '8,700DVKDbSynthesized': [2678], 'house.0.23': [2680], '0.010.74': [2682], '0.0353': [2684], '6267': [2686], '274,330': [2688], '5902,790': [2690], '312ADVKDbSynthesized': [2692], 'house.0.11': [2694], '0.000.77': [2696], '0.0335': [2698], '4243': [2700], '273,080': [2702], '4373,180': [2704], '389KDVKDbSynthesized': [2706], 'house.0.59': [2708], '0.020.79': [2710], '0.03133': [2712], '13407': [2714], '364,390': [2716], '4941,940': [2718], '188AKDVKDbSynthesized': [2720], 'house.0.63': [2722], '0.020.48': [2724], '0.01129': [2726], '11439': [2728], '274,840': [2730], '4441,100': [2732], '77QKDVKDbSynthesized': [2734], 'house.0.43': [2736], '0.020.19': [2738], '0.0192': [2740], '12356': [2742], '394,690': [2744], '657560': [2746], '69"Quencher"cAbz-QKDVKDGKYSQY(NO2).0.25': [2748], '0.020.005': [2750], '0.001173': [2752], '27192': [2754], '681,450': [2756], '25326': [2758], '10a': [2760], 'Commercial': [2761], 'source.b': [2762], 'Synthesized': [2763], 'house.c': [2765], 'Abz-QKDVKDGKYSQY(NO2).': [2766], 'Open': [2767], 'table': [2768], 'new': [2771], 'tab': [2772], 'nm': [2774, 2811, 3479], 'amc-linked': [2790], '(concentration': [2792], 'ranging': [2793], '1': [2795, 3404], '1200': [2797], 'µm)': [2798], 'final': [2804, 3472, 3504], 'volume': [2805, 3025], '80': [2807], 'µl.': [2808, 3028], 'Similarly,': [2809], 'Abz-QKDVKDGKYSQY(NO2)': [2823], '(synthesized': [2824], 'Fmoc': [2827], 'chemistry': [2828], 'Applied': [2831], 'Biosystems': [2832], '433A': [2833], 'Peptide': [2834, 3927, 4007], 'Synthesizer;': [2835], 'Y(NO2)': [2836], 'denotes': [2837], 'residue).': [2840], 'Generation': [2841], 'Abz': [2846], 'above.': [2851], 'initial': [2853], 'rates': [2855], 'fluorescence': [2857], 'concentrations': [2860, 3018], 'obtain': [2867], 'plots': [2868], 'versus': [2871], 'concentration.': [2873], '(Km)': [2876], '(kcat)': [2881], 'plots.': [2886], 'Absolute': [2887], 'Km': [2888], 'kcat': [2890], 'calculated': [2893], 'standard': [2896], 'curve': [2897], 'pCMV-SPORT6-GSTP1,': [2902], 'pCMV-': [2903], 'SPORT6-HDGF,': [2904], 'pCMV-SPORT6-MYBBP1a,': [2905], 'pCMV-SPORT6-NUCKS1,': [2906], 'pCMV-SPORT6-PKM2,': [2907], 'pCMV-SPORT6-RPL28,': [2908], 'pCMV-SPORT6.1-MKI67ip,': [2909], 'pYX-ASC-FAM21': [2910], '(all': [2911], 'German': [2914], 'Resource': [2915], 'Center': [2916], 'Genome': [2918], 'Research': [2919], '(RZPD),': [2920], 'Berlin,': [2921], 'Germany),': [2922], 'pFLCI-ACTA2': [2923], '(from': [2924], 'Geneservice': [2925], 'Ltd.),': [2926], 'four': [2929], 'pCR3-based': [2930], 'plasmids': [2931, 3269], 'under': [2933], '"Plasmids"': [2934], 'templates': [2938], '[35S]methionine': [2940], '(PerkinElmer': [2941], 'Life': [2942], 'Sciences)-radiolabeled': [2943], 'coupled': [2946], 'transcription/translation': [2947], 'rabbit': [2950], 'reticulocyte': [2951], 'according': [2954], "manufacturer's": [2957], 'instructions': [2958], '(Promega).': [2959], 'Before': [2960], 'treatment,': [2962], 'translated': [2964, 2999], 'samples': [2966, 3030, 3465], 'alkylated': [2968, 3426, 4035], '(IAA)': [2973], '30': [2975, 2978, 3027, 3432, 3435], '°C': [2979, 3011, 3355, 3436], 'dark.': [2982], 'Excess': [2983], 'IAA': [2984, 3444], 'removed': [2986], 'making': [2988], 'desalting': [2992], 'spin': [2993], 'columns': [2994, 3451], '(Perbio': [2995], 'Science).': [2996], 'desalted': [2998, 3448], '(2': [3001], 'µl)': [3002], 'subsequently': [3004], '1.5': [3007, 3491], 'h': [3008, 3492], 'indicated': [3017], 'total': [3024], 'Next,': [3029], 'boiled': [3032], 'after': [3036], 'addition': [3037], 'Laemmli': [3039], 'buffer,': [3040], 'separated': [3041], '10,': [3043], '15,': [3044], '20%': [3046], 'SDS-PAGE,': [3047], 'transferred': [3049], 'nitrocellulose': [3052], 'membrane': [3053], '(Schleicher': [3054], '&': [3055], 'Schuell)': [3056], 'semidry': [3058], 'blotting.': [3059], 'blotted': [3061], 'membranes': [3062], 'sealed': [3064], 'keep': [3066], 'them': [3067], 'humid': [3068], 'exposed': [3070], 'film': [3073], '(Amersham': [3074], 'Biosciences': [3075], 'Hyperfilm™': [3076], 'ECL)': [3077], 'radiography.': [3079], 'cDNA': [3081, 3123, 3147, 3186], 'encoding': [3082, 3124, 3148, 3187, 3211], 'amplified': [3085, 3104, 3151, 3169], 'PCR': [3087, 3134, 3153, 3197], 'pYX-ASC-RPS18': [3090], 'vector': [3091, 3120, 3183, 3226], '(RZPD)': [3092], 'primer': [3096, 3139, 3161, 3202], 'pair:': [3097, 3140, 3162, 3203], 'RPS18-forward,': [3098], '5′-CTGAATTCGCCATGTCTCTAGTGATCCC-3′,': [3099], 'RPS18-reverse,': [3101], '5′-ATATGCGGCCGCTCATTTCTTCTTGGATACACCC-3′.': [3102], 'product': [3105, 3170], 'digested': [3107, 3172], 'EcoRI': [3109], 'NotI': [3111, 3174], 'cloned': [3113, 3176, 3222], 'multiple': [3116, 3179], 'cloning': [3117, 3180], 'site-modified': [3118, 3181], 'pCR3': [3119, 3182], '(Invitrogen).': [3121, 3184], '"ADVKD"': [3126], 'mutant': [3127, 3190], 'RPS18-K88A-forward,': [3141], '5′-AACAGACAGGCGGATGTGAAGGATGGGAAG-3′,': [3142], 'RPS18-K88A-reverse,': [3144], '5′-TTCACATCCGCCTGTCTGTTCAGGAACCAG-3′.': [3145], 'PARP': [3149, 3192], 'pGEM-PARP1': [3156], 'plasmid': [3157], 'PARP-forward,': [3163], '5′-ATCTGCGGCCGCTCATGGCGGAGTCTTCGGATAAGC-3′,': [3164], 'PARP-reverse,': [3166], '5′-TATAGCGGCCGCTCCCAATTACCACAGGGAGGTC-3′.': [3167], 'into': [3177], '"KDEVD"': [3189], 'PARP-G210K-forward,': [3204], '5′-AGAGAAAAAAGGATGAGGTGGATGGAGTGG-3′,': [3205], 'PARP-G210K-reverse,': [3207], '5′-ACCTCATCCTTTTTTCTCTTTCCTTCACTCTTGC-3′.': [3208], 'cDNAs': [3210], 'devoid': [3215], 'prodomain': [3218], '(i.e.': [3219, 3330], 'caspase-p30)': [3220], 'pLT10TH': [3225], 'His6': [3231], 'tag': [3232], 'All': [3268], 'sequence-verified.': [3271], 'Mf4/4': [3272, 3374], '(30Desmedt': [3273], 'Rottiers': [3275], 'Dooms': [3277], 'Grooten': [3281], 'Macrophages': [3283], 'induce': [3284], 'immunity': [3286], 'activating': [3288], 'Th1': [3289], 'responses': [3291], 'suppressing': [3293], 'Th2': [3294], 'responses.J.': [3296], 'Immunol.': [3297], '160:': [3299], '5300-5308PubMed': [3300], 'grown': [3306], 'lipopolysaccharide-free': [3308], 'RPMI': [3309, 3337], '1640': [3310, 3338], 'medium': [3311, 3339], '(Invitrogen)': [3312], 'l-[12C6]arginine,': [3315], 'l-[13C6]arginine,': [3316], 'l-[13C6,15N4]arginine': [3318], '(Cambridge': [3319], 'Isotope': [3320], 'Laboratories,': [3321], 'Andover,': [3322], 'MA)': [3323], 'concentration': [3326, 3335, 3505], '287': [3328], '25%': [3331], 'normal': [3334], 'l-arginine': [3342], 'proline': [3344], 'conversion': [3345], 'observed).': [3348], 'populations': [3350], 'cultured': [3352], 'humidified': [3358], '5%': [3359], 'CO2': [3360], 'atmosphere': [3361], 'least': [3364], 'five': [3365], 'doublings': [3366], 'incorporation': [3369], 'l-arginine.': [3373], 'detached': [3377], 'enzyme-free': [3379], 'dissociation': [3381], '(Invitrogen),': [3383], 'washed': [3384], 'D-PBS': [3386, 3391, 3453], "(Dulbecco's": [3387], 'PBS),': [3388], 'resuspended': [3389], 'supplemented': [3392, 3454, 3467], 'oxidized': [3406, 3460], 'glutathione,': [3407], 'freeze-thawed': [3409], 'times.': [3411], 'Lysates': [3412], 'cleared': [3414], 'centrifugation': [3416], '15': [3418], '20,000': [3421], '×': [3422], 'g.': [3423], 'Proteins': [3424], 'dark,': [3439], 'remove': [3442], 'excess': [3443], 'separately': [3447], 'NAP-10': [3450], 'glutathione.': [3461], 'separate': [3464], 'DTT': [3469], '(10': [3470], 'concentration)': [3473], '130': [3478], '(l-[12C6]Arg)': [3482], '(l-[13C6]Arg)': [3485], 'left': [3487], 'untreated': [3488], '(l-[13C6,15N4]Arg)': [3489], '°C.': [3495], 'Solid': [3496], 'guanidinium': [3497], 'hydrochloride': [3498], 'then': [3500], 'added': [3501], '4': [3507], 'm': [3508], 'ESI': [3646, 3731], 'LC-MS/MS': [3647], 'ESI-Q-TOF': [3712], 'MS/MS': [3713, 3734], 'fragmentation': [3715, 3953, 3990], 'pkl': [3720], 'files': [3721, 3740], 'MassLynx®': [3724], 'software': [3725, 3745], '(version': [3726, 3746, 3770, 3791], '4.1,': [3727], 'Waters': [3728], 'Corp.),': [3729], 'ion': [3732, 3961], 'trap': [3733, 3962], 'mgf': [3739], 'Automation': [3743], 'Engine': [3744], '3.2,': [3747], 'Bruker).': [3748], 'Peptides': [3749], 'locally': [3754], 'installed': [3755], 'version': [3756, 3763], 'Mascot': [3759], 'search': [3761, 3923], 'engine': [3762], '(Matrix': [3765], 'Science)': [3766], 'Swiss-Prot': [3769], '53.2': [3771], 'UniProtKB/Swiss-Prot': [3773], 'database,': [3775, 3796], '269,293': [3777], 'sequence': [3778, 3799], 'entries': [3779, 3800], '13,316': [3782], 'originated': [3783], 'sequences)': [3787], 'TrEMBL': [3789], 'databases': [3790, 3815, 3828], '35.0': [3792], 'UniProtKB/TrEMBL': [3794], '3,874,166': [3798], 'comprising': [3801], '52,403': [3802], 'entries)': [3805], 'searched': [3807, 3841], 'restriction': [3809], 'proteins.': [3812], 'Truncated': [3813], 'DBToolkit': [3818], '(31Martens': [3819], 'DBToolkit:': [3825], 'peptide-centric': [3830], 'proteomics.Bioinformatics.': [3831], '3584-3585Crossref': [3834], '(121)': [3837], 'parallel': [3843], 'pick': [3845], 'up': [3846], 'efficiently': [3851], '(e.g.': [3852], 'Scholar': [3888], '32Vande': [3890], 'Walle': [3891], 'Lamkanfi': [3896], 'Saelens': [3898], 'X.': [3899], 'HtrA2/Omi': [3909], 'substrates.J.': [3910], 'Proteome': [3911], 'Res.': [3912], '1006-1015Crossref': [3915], '(103)': [3918], 'used.': [3926], 'tolerance': [3929, 3939, 3966, 3976], 'set': [3931, 3941, 3968, 3978, 3995, 4010, 4019], '0.2': [3933], 'Da,': [3934, 3971], 'fragment': [3937, 3974], '0.1': [3943], 'Da': [3944, 3981], '"ESI-QUAD-TOF"': [3947], 'selected': [3949, 3986], 'instrument': [3950, 3987], 'rules': [3954], 'Q-TOF': [3957], 'Premier': [3958], 'data.': [3959], 'For': [3960], 'data,': [3963], '0.5': [3970, 3980], '"ESI-IT"': [3984], 'rules.': [3991], 'Endoproteinase': [3992], 'Arg-C/P': [3993], 'enzyme': [3998], 'maximum': [4001], 'number': [4002], 'missed': [4005], 'charge': [4008], '1+,': [4012], '2+,': [4013], '3+.': [4015], 'Variable': [4016], 'modifications': [4017], 'methionine': [4021, 4024], 'oxidation': [4022], '(to': [4023], 'sulfoxide),': [4025], 'pyroglutamate': [4026], 'formation': [4027, 4032], 'glutamine,': [4030], 'pyrocarbamidomethyl': [4031], 'cysteine,': [4036], 'deamidation': [4037], 'asparagine,': [4039], 'ace': [4040]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2119294728', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-10T13:44:29.089529', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
