Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2119061302', 'doi': 'https://doi.org/10.2337/diab.33.5.470', 'title': 'Prevention and Reversal of Defective Axonal Transport and Motor Nerve Conduction Velocity In Rats with Experimental Diabetes by Treatment with the Aldose Reductase Inhibitor Sorbinil', 'display_name': 'Prevention and Reversal of Defective Axonal Transport and Motor Nerve Conduction Velocity In Rats with Experimental Diabetes by Treatment with the Aldose Reductase Inhibitor Sorbinil', 'publication_year': 1984, 'publication_date': '1984-05-01', 'ids': {'openalex': 'https://openalex.org/W2119061302', 'doi': 'https://doi.org/10.2337/diab.33.5.470', 'mag': '2119061302', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6202576'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2337/diab.33.5.470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057795207', 'display_name': 'David R. Tomlinson', 'orcid': 'https://orcid.org/0000-0002-4417-5502'}, 'institutions': [{'id': 'https://openalex.org/I4210137227', 'display_name': "Queen's Medical Centre", 'ror': 'https://ror.org/03ap6wx93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334287468', 'https://openalex.org/I4210137227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David R Tomlinson', 'raw_affiliation_strings': ["Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre\u2008Clifton Boulevard, Nottingham NG7 2UH, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre\u2008Clifton Boulevard, Nottingham NG7 2UH, United Kingdom", 'institution_ids': ['https://openalex.org/I4210137227']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084574306', 'display_name': 'Richard J Moriarty', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210137227', 'display_name': "Queen's Medical Centre", 'ror': 'https://ror.org/03ap6wx93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334287468', 'https://openalex.org/I4210137227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard J Moriarty', 'raw_affiliation_strings': ["Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre\u2008Clifton Boulevard, Nottingham NG7 2UH, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre\u2008Clifton Boulevard, Nottingham NG7 2UH, United Kingdom", 'institution_ids': ['https://openalex.org/I4210137227']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105837061', 'display_name': 'John H. Mayer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210137227', 'display_name': "Queen's Medical Centre", 'ror': 'https://ror.org/03ap6wx93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334287468', 'https://openalex.org/I4210137227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J Heidi Mayer', 'raw_affiliation_strings': ["Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre\u2008Clifton Boulevard, Nottingham NG7 2UH, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre\u2008Clifton Boulevard, Nottingham NG7 2UH, United Kingdom", 'institution_ids': ['https://openalex.org/I4210137227']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.308, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 134, 'citation_normalized_percentile': {'value': 0.944032, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '33', 'issue': '5', 'first_page': '470', 'last_page': '476'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12533', 'display_name': 'Aldose Reductase and Taurine', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12533', 'display_name': 'Aldose Reductase and Taurine', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sorbinil', 'display_name': 'Sorbinil', 'score': 0.988105}, {'id': 'https://openalex.org/keywords/diabetic-neuropathy', 'display_name': 'Diabetic Neuropathy', 'score': 0.4519016}], 'concepts': [{'id': 'https://openalex.org/C2776614240', 'wikidata': 'https://www.wikidata.org/wiki/Q1259458', 'display_name': 'Sorbinil', 'level': 5, 'score': 0.988105}, {'id': 'https://openalex.org/C2777374081', 'wikidata': 'https://www.wikidata.org/wiki/Q4713968', 'display_name': 'Aldose reductase inhibitor', 'level': 4, 'score': 0.8963177}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7243153}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.67127025}, {'id': 'https://openalex.org/C2776439734', 'wikidata': 'https://www.wikidata.org/wiki/Q414213', 'display_name': 'Aldose reductase', 'level': 3, 'score': 0.6422578}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.590339}, {'id': 'https://openalex.org/C179253579', 'wikidata': 'https://www.wikidata.org/wiki/Q6276958', 'display_name': 'Nerve conduction velocity', 'level': 2, 'score': 0.55443865}, {'id': 'https://openalex.org/C2781149210', 'wikidata': 'https://www.wikidata.org/wiki/Q307869', 'display_name': 'Sciatic nerve', 'level': 2, 'score': 0.5014572}, {'id': 'https://openalex.org/C2776779347', 'wikidata': 'https://www.wikidata.org/wiki/Q245280', 'display_name': 'Sorbitol', 'level': 2, 'score': 0.4684598}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46233413}, {'id': 'https://openalex.org/C2779178840', 'wikidata': 'https://www.wikidata.org/wiki/Q2046550', 'display_name': 'Diabetic neuropathy', 'level': 3, 'score': 0.4519016}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.29412368}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.06523883}], 'mesh': [{'descriptor_ui': 'D001370', 'descriptor_name': 'Axonal Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D003929', 'descriptor_name': 'Diabetic Neuropathies', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D048289', 'descriptor_name': 'Imidazolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009431', 'descriptor_name': 'Neural Conduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000449', 'descriptor_name': 'Aldehyde Reductase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000449', 'descriptor_name': 'Aldehyde Reductase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002795', 'descriptor_name': 'Choline O-Acetyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002795', 'descriptor_name': 'Choline O-Acetyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003929', 'descriptor_name': 'Diabetic Neuropathies', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D003929', 'descriptor_name': 'Diabetic Neuropathies', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D003929', 'descriptor_name': 'Diabetic Neuropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007294', 'descriptor_name': 'Inositol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007294', 'descriptor_name': 'Inositol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012584', 'descriptor_name': 'Sciatic Nerve', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012584', 'descriptor_name': 'Sciatic Nerve', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D013012', 'descriptor_name': 'Sorbitol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013012', 'descriptor_name': 'Sorbitol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2337/diab.33.5.470', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6202576', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2358186117', 'https://openalex.org/W217985093', 'https://openalex.org/W2164577386', 'https://openalex.org/W2066905280', 'https://openalex.org/W2064616098', 'https://openalex.org/W2059474142', 'https://openalex.org/W2026940981', 'https://openalex.org/W2003917823', 'https://openalex.org/W2003221507', 'https://openalex.org/W1975378224'], 'abstract_inverted_index': {'This': [0], 'investigation': [1], 'was': [2, 214], 'designed': [3], 'to': [4, 122, 139, 198, 201], 'determine': [5, 140], 'whether': [6, 141], 'the': [7, 13, 56, 84, 94, 99, 142, 178, 184, 225, 256], 'aldose': [8], 'reductase': [9], 'inhibitor': [10], 'Sorbinil': [11, 89, 129, 182, 208, 222, 239], 'prevented': [12, 98, 244, 262], 'development': [14, 100], 'of': [15, 19, 30, 47, 58, 77, 81, 96, 101, 118, 148, 156, 188, 221, 227, 233, 252, 266], 'or': [16, 33, 136], 'reversed': [17, 246, 264], 'defects': [18, 72, 175, 265], 'nerve': [20, 43, 68, 253, 267], 'conduction': [21, 44, 268], 'and': [22, 53, 79, 108, 162, 200, 245, 250, 263, 269], 'axonal': [23, 271], 'transport': [24], 'in': [25, 40, 83, 105, 241, 255], 'streptozotocin-diabetic': [26], 'rats.': [27], 'Untreated': [28], 'diabetes': [29, 97, 126, 150], 'either': [31], '3': [32, 123, 137, 146, 186], '6': [34], 'wk': [35, 124, 138, 147, 187, 220, 232], 'duration': [36], 'caused': [37], 'a': [38, 65, 113, 189], 'fall': [39], 'sciatic': [41, 67, 85, 257], 'motor': [42], 'velocity': [45], '(MNCV)': [46], '6–9': [48], 'm/s': [49], '(P': [50, 166], '<': [51, 167], '0.001)': [52], 'significantly': [54, 158], 'reduced': [55, 216], 'accumulation': [57, 76, 165, 213, 249], 'axonally': [59], 'transported': [60], 'choline': [61, 163], 'acetyltransferase': [62, 164], 'activity': [63], 'against': [64], '24-h': [66], 'crush.': [69], 'These': [70, 235], 'functional': [71], 'were': [73, 120, 196], 'associated': [74], 'with': [75, 88], 'sorbitol': [78], 'depletion': [80, 251], 'myo-/nositol': [82], 'nerve.': [86, 258], 'Treatment': [87], '(25': [90], 'mg/kg/day,': [91], 'p.o.)': [92], 'throughout': [93, 209], 'period': [95, 192], 'all': [102], 'these': [103, 174], 'abnormalities': [104, 143], 'both': [106, 160, 247], '3-': [107], '6-wk': [109, 190], 'diabetic': [110, 191, 202, 242], 'groups.': [111], 'In': [112], 'second': [114, 185], 'study,': [115], 'three': [116], 'groups': [117], 'rats': [119, 203, 243], 'subject': [121], 'untreated': [125, 149], 'followed': [127], 'by': [128, 217], 'treatment': [130, 157, 240, 260], '(as': [131], 'above)': [132], 'for': [133, 183], '1,': [134], '2,': [135], 'expected': [144], 'from': [145], 'could': [151], 'be': [152], 'reversed.': [153], 'One': [154], 'week': [155], 'elevated': [159], 'MNCV': [161], '0.05).': [168], 'The': [169, 259], 'longer': [170], 'treatments': [171], 'progressively': [172], 'ameliorated': [173], 'such': [176], 'that': [177, 180, 195, 204, 238], 'group': [179], 'received': [181], 'gave': [193], 'values': [194], 'similar': [197], 'controls': [199], 'had': [205], 'been': [206], 'given': [207], 'their': [210], 'diabetes.': [211], 'Sorbitol': [212, 248], 'markedly': [215], 'only': [218], '1': [219], 'treatment,': [223], 'but': [224], 'normalization': [226], 'myo-inositol': [228, 254], 'levels': [229], 'required': [230], '2': [231], 'treatment.': [234], 'findings': [236], 'indicate': [237], 'also': [261], 'orthograde': [270], 'transport.': [272]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2119061302', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T20:34:19.918635', 'created_date': '2016-06-24'}