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[97], 'bubonic': [99], 'plague,': [100], 'women': [102, 3992], 'Victorian': [104], 'times': [105, 2742, 2769], 'applied': [106, 3328], 'compounds': [108, 133], 'faces': [111], 'whiten': [113], 'complexions.': [115], 'Hippocrates,': [116], 'father': [118], 'western': [120], 'medicine,': [121], 'recorded': [122], 'usefulness': [124], 'topical': [127], 'remedy': [128], 'skin': [130, 231, 433, 495, 549, 586, 642, 696, 775, 801, 1729, 2616, 2837, 3179], 'ulcers.Today,': [131], 'are': [134, 157, 357, 419, 469, 510, 524, 638, 666, 805, 852, 900, 927, 1070, 1133, 1300, 1431, 1558, 1710, 1740, 1891, 2158, 2256, 2318, 2462, 2690, 2785, 3036, 3156, 3581, 3636, 3776, 3885, 4190, 4322], 'still': [135, 2096, 3705], 'used': [136, 199, 2448], 'pharmaceutical': [138], 'purposes.': [139], 'Arsenic': [140, 739, 1999, 2563, 3132, 3141, 3761, 4265], 'trioxide': [141, 184], 'is': [142, 632, 726, 789, 885, 1115, 1140, 1206, 1216, 1485, 1516, 1540, 1624, 1695, 1767, 1843, 1933, 2014, 2095, 2198, 2241, 2280, 2342, 2423, 2440, 2510, 2676, 3195, 3215, 3287, 3334, 3350, 3449, 3470, 3554, 3591, 3640, 3840, 3925, 3952, 3970, 4210, 4242, 4446, 4483], 'known': [143, 1295, 1541], 'its': [145, 1832, 1856, 1994], 'use': [146, 1498, 3104, 3677, 4380], 'treatment': [149], 'acute': [151, 395, 404], 'promyelocytic': [152], 'leukemia': [153], 'patients': [155], 'who': [156, 637, 665, 706, 1064, 1132, 2302, 2731, 3542], 'unresponsive': [158], 'to,': [159], 'or': [160, 499, 1939, 2157, 2260, 2295, 2362, 2607, 3368, 3516, 3547, 3873, 3889, 4003, 4428], 'have': [161, 186, 257, 539, 1189, 1284, 1574, 1662, 1687, 2077, 2107, 2215, 2775, 3355, 3506, 4062, 4083, 4299, 4390], 'relapsed': [162], 'from,': [163], 'certain': [164, 1150, 3934], 'chemotherapy': [165, 204], 'agents.': [166], 'Research': [167, 283, 307, 742, 979, 2026, 3028, 3758], 'published': [168, 287, 565, 1351, 2027, 2713, 2980], '1': [171, 1723, 2812, 3396, 3750, 3814], 'April': [172, 2030, 2804], '2005': [173, 1034, 1839, 3303], 'issue': [174, 297, 304, 570, 617, 1359, 1417, 1840, 2032, 2534, 2718, 2815, 2986, 3239, 3304, 3399, 3410, 4212], 'Journal': [177, 1362], 'Clinical': [179], 'Oncology': [180], 'suggests': [181, 365], 'that': [182, 195, 215, 320, 366, 574, 634, 663, 982, 1286, 1648, 1778, 1846, 1855, 2005, 2022, 2203, 2390, 2443, 2576, 2722, 2743, 2770, 2797, 2824, 2890, 2931, 2939, 3035, 3055, 3075, 3115, 3177, 3243, 3279, 3327, 3351, 3508, 3552, 3653, 3783, 3796, 3820, 3864, 3882, 3927, 4034, 4061, 4127, 4189, 4263, 4308, 4325, 4492, 4500], 'may': [185, 197, 368, 452, 644, 702, 814, 1163, 1727, 1784, 2165, 2173, 2391, 2453, 2492, 2671, 2901, 2971, 3006, 3116, 3247, 3354, 3510, 3747, 3930, 4016, 4039, 4068, 4309, 4493], 'therapeutic': [187], 'uses': [188], 'malignancies': [191, 382], 'well,': [193], 'it': [196, 813, 1754, 2322, 2603, 2650, 2652, 3454, 3553, 3951, 4366], 'be': [198, 261, 369, 527, 645, 715, 815, 1055, 1164, 1372, 1771, 1785, 2008, 2166, 2174, 2324, 2358, 2392, 2454, 2672, 3080, 3159, 3248, 3511, 3609, 3700, 3748, 3896, 3931, 4017, 4069, 4226, 4238, 4329, 4343, 4399], 'combination': [201], 'with': [202, 313, 403, 544, 774, 830, 940, 1403, 1585, 1613, 1632, 1852, 2249, 2258, 2513, 2553, 2588, 2746, 2842, 2854, 3003, 3017, 3067, 3295, 3323, 3561, 3602, 3647, 3913, 3933, 4094, 4167, 4217, 4502, 4508], 'drugs': [205], 'expand': [207], 'benefits.And': [209], 'no': [211, 1185, 3942], 'toxicologist': [212], 'would': [213, 2426, 3608], 'deny': [214], 'chronic': [216, 375, 397, 463, 476, 517, 592, 1345, 2958, 2965, 3648], 'exposure': [218, 377, 405, 594, 788, 810, 867, 899, 913, 1060, 1125, 1194, 1210, 1399, 2384, 2402, 2435, 2830, 3342, 3416, 3522, 3573, 3746, 3845, 3940, 4432, 4486, 4498], 'places': [219], 'people': [220, 636, 705, 773, 851, 1159, 1288, 1341, 1408, 1430, 1707, 1726, 2301, 3580, 4462], 'at': [221, 270, 689, 744, 853, 968, 1342, 1373, 1432, 1468, 1711, 1952, 2052, 2274, 2397, 2480, 2499, 2594, 2596, 2628, 2638, 2691, 3024, 3206, 3735, 3742, 3917, 3998, 4036, 4076, 4134, 4187], 'risk': [222, 854, 938, 1343, 1374, 1433, 1712, 2419, 2450, 2498, 2551, 2694, 2725, 2758, 3442, 3645, 3804, 3811, 3911, 3999], 'host': [225], 'adverse': [227, 601, 857, 3166, 4503], 'health': [228, 1110, 3848, 3982, 4452], 'effects,': [229, 761], 'internal': [233, 699], 'cancers': [234, 700, 2838, 3504], '(of': [235], 'bladder,': [237], 'kidney,': [238], 'liver,': [239], 'lung,': [240, 711], 'colon,': [241], 'uterus,': [242], 'prostate,': [243], 'stomach)': [245], 'diabetes': [247, 552], 'mellitus': [248], 'vascular,': [250], 'reproductive,': [251], 'developmental,': [252], 'neurological': [254], 'effects.': [255], 'Studies': [256, 532, 688], 'shown': [258, 1024, 1285, 1796], 'potent': [263], 'endocrine': [264], 'disruptor,': [265], 'altering': [266], 'hormone-mediated': [267], 'cell': [268, 1826, 2271, 3483, 3485], 'signaling': [269, 345], 'extremely': [271, 3935, 4243], 'low': [272, 2747, 3936, 4096, 4175], 'concentrations.Joshua': [273], 'Hamilton,': [274], 'program': [275, 2043], 'director': [276, 682, 736, 2044, 4250], 'Dartmouth': [279, 2481], 'College': [280], 'Superfund': [281], 'Basic': [282], 'Program,': [284], 'colleagues': [286, 2528, 3058, 3311, 3373], 'papers': [288], 'on': [289, 325, 338, 603, 1037, 1073, 1124, 1134, 1411, 1562, 1816, 1988, 1996, 2465, 2469, 2540, 2883, 3123, 3271, 3596, 3622, 3876, 3980, 4404], 'latter': [291, 4155], 'topic': [292, 838], 'March': [295, 568], '2001': [296, 3765, 4269], 'EHP': [299, 619, 2034, 2806], 'August': [302, 1415, 2813, 3397], '2004': [303, 616, 1358, 1416, 2031, 2533, 2805, 2814, 2879, 2985, 3238, 3398, 3409], 'Chemical': [306], 'Toxicology.': [309], '"We': [310, 3032, 4082], 'demonstrated': [311, 2057], 'glucocorticoid': [315], 'receptor': [316, 344], 'subsequently': [318], 'showed': [319, 573], 'similar': [323, 336, 2058], 'effects': [324, 337, 389, 461, 477, 602, 858, 1858, 1919, 1987, 1995, 2897, 2956, 3167, 3226, 3631, 3849, 3929, 4173, 4315, 4348, 4496, 4504], 'all': [326, 945, 1324, 3490, 4140], 'five': [327], 'steroid': [328], 'receptors,"': [329], 'says': [330, 679, 733, 981, 1348, 2264, 2474, 2618, 2687, 3019, 3430, 3568, 3605, 3768, 3945, 4111, 4247, 4374], 'Hamilton.': [331], '"Furthermore,': [332], 'we': [333, 661, 3277], 'recently': [334, 1023], 'found': [335, 1191, 1486, 2109, 2404, 2721, 3059, 3278, 3533], 'members': [340, 4158], 'nuclear': [343], 'family,': [346], 'including': [347, 1031, 1752, 2181], 'retinoic': [348], 'acid': [349], 'thyroid': [351], 'hormone': [352], 'receptors."': [353], 'Since': [354], 'these': [355, 475, 783, 1113, 1198, 1273, 1352, 1791, 1889, 1918, 2316, 3519, 3743, 4235], 'receptors': [356], 'central': [358], 'many': [361, 381, 521, 758, 1271, 1287, 3673], 'biological': [362, 2024, 2505], 'processes,': [363], 'Hamilton': [364], 'important': [371, 2208, 3556, 3953], 'way': [372], 'by': [373, 529, 580, 992, 998, 1675, 1690, 1829, 1897, 2035, 2144, 2176, 2508, 2709, 3008, 3262, 3339, 4041], 'which': [374, 884, 926, 1004, 2195, 2314, 3847], 'contributes': [378], 'well': [384, 408, 542, 1161, 1175, 2064, 2969, 3101, 3637, 4355], 'nonmalignant': [386], 'diseases.The': [387], 'noncancer': [388, 759, 784], 'arise': [392, 703], 'both': [394, 505, 548, 1527, 1630, 1907, 1916], 'exposures.': [398], 'Among': [399, 1436], 'those': [400, 664, 1568, 2869, 3620, 3996, 4386, 4489], 'symptoms': [401, 523], 'linked': [402, 540, 829, 1612], 'arsenic-laced': [407, 1009], 'water': [409, 543, 628, 871, 879, 987, 1011, 1136, 1139, 1162, 1449, 1609, 2699, 2739, 2765, 2970, 3652, 3698, 4445], '(typically': [410], 'containing': [411, 1450], 'more': [412, 470, 646, 672, 816, 886, 1075, 1337, 1404, 1772, 2152, 2167, 2261, 2393, 2429, 2464, 2866, 3121, 3160, 3250, 3288, 3517, 4029, 4331, 4339], 'than': [413, 889, 1338, 1405, 1454, 2410, 2468, 2868, 3162, 3186, 3252, 3363, 3658, 4072, 4333], '1,200': [414], 'micrograms': [415], 'per': [416], 'liter': [417], '[μg/L])': [418], 'abdominal': [420], 'pain,': [421], 'vomiting,': [422], 'diarrhea,': [423], 'muscular': [424], 'weakness': [425], 'cramping,': [427], 'pain': [428], 'extremities,': [431], 'erythematous': [432], 'eruptions,': [434], 'swelling': [436], 'eyelids,': [439], 'feet,': [440], 'hands.': [442], 'A': [443, 1310, 1812, 2707], 'progressive': [444], 'deterioration': [445], 'motor': [448], 'sensory': [450], 'responses': [451], 'also': [453, 596, 701, 756, 1071, 1395, 2216, 2786, 2859, 2893, 3505], 'result,': [454, 1269], 'finally': [455], 'leading': [456, 2346], 'shock': [458], 'death.The': [460], 'poisoning': [465, 1389, 1715], '(also': [466], 'called': [467], 'arsenicosis)': [468], 'complex.': [471], 'Aside': [472], 'cancer,': [474, 2593, 3807], 'include': [478, 1588, 1649, 2921, 3089, 4488], 'atherosclerosis,': [479], 'diabetes,': [480], 'hypertension,': [481], 'anemia,': [482], 'liver': [483], 'disorders,': [484], 'kidney': [485], 'damage,': [486, 1823], 'headache,': [487], 'confusion,': [488], 'peripheral': [489, 826], 'neuropathy,': [490], 'variety': [493, 2178], 'lesions,': [496], 'notably': [497], 'hyperkeratosis,': [498], 'thickening': [500], 'skin,': [503, 1051], 'hypo-': [506], 'hyperpigmentation.Skin': [508], 'lesions': [509, 550, 587, 643, 776, 1730, 3180], 'most': [512, 907, 995, 1129, 1328, 1547, 2916, 4362, 4449], 'outward': [514, 3197], 'sign': [515], 'exposure,': [519, 1477, 2186, 2556, 2960, 4318], 'though': [520, 1052, 3809], 'dermatologic': [522], 'thought': [525], 'mediated': [528], 'nutritional': [530], 'factors.': [531, 4005], 'conducted': [533], 'Taiwan,': [535, 812], 'India,': [536, 564, 1330, 1572], 'Bangladesh': [538, 660, 1202, 1326, 1570, 2909, 2998, 3671, 4060], 'high-arsenic': [541, 834], 'incidence': [546, 781], 'dose-responsive': [555], 'pattern.': [556], 'One': [557, 1789, 3345], 'recent': [558, 1460], 'population': [559, 1252, 3274, 4010, 4305], 'study': [560, 2543, 2708, 3558, 3822], 'West': [562, 657, 1038, 1204, 2911, 3065], 'Bengal,': [563, 2912], '2003': [569], 'Epidemiology,': [572, 2720], 'lowest': [576], 'peak': [577], 'ingested': [579, 722], 'confirmed': [582], 'case': [583, 4156], 'arsenic-induced': [585, 2337, 4337], '115': [589], 'μg/L.Among': [590], 'children,': [591, 3994], 'reported': [598, 620, 2529, 2822, 2889, 3234, 3393], 'cause': [600, 729], 'digestive,': [605], 'respiratory,': [606], 'cardiovascular,': [607], 'nervous': [609], 'systems.': [610], 'An': [611, 3137, 3212], 'article': [612, 954, 1814, 2807], 'September': [615, 3237], 'intellectual': [621], 'impairment': [622], 'occurring': [623], 'when': [624, 1227, 2246, 3493, 3883, 4365], 'drinking': [627, 835, 870, 1127, 1138, 1160, 1212, 1254, 1700, 1717, 2698, 3651, 3697, 4444], 'exceeded': [629], '50': [630, 1171, 1455, 2411, 3681], 'μg/L.There': [631], 'evidence': [633, 2678], 'arsenic-exposed': [635], 'predisposed': [639], 'noncancerous': [641, 709], 'vulnerable': [647, 2168], 'cancers.': [650, 4358], '"During': [651], 'our': [652, 3269, 4455], 'long': [653, 3513], 'field': [654], 'experience': [655], 'Bengal': [658, 1039, 1205, 3066], 'observed': [662, 3176, 4084], 'suffering': [667], 'severe': [669, 1397, 3633], 'keratosis': [670], 'appear': [671, 2701, 4327], 'likely': [673, 2917], 'develop': [675, 2303], 'cancer': [676, 697, 725, 1196, 1757, 1762, 1802, 2093, 2238, 2304, 2351, 2396, 2550, 2728, 2757, 3537, 3888, 4285], 'later': [677], 'on,"': [678], 'Dipankar': [680], 'Chakraborti,': [681, 1704], 'School': [685, 746, 1464], 'Environmental': [687, 970, 977, 4254], 'Jadavpur': [690], 'University': [691, 750, 1471, 2276], 'Calcutta.': [693], '"Not': [694], 'only': [695, 2558, 2946, 3060, 3329, 4323], 'but': [698, 919, 1546, 1573, 2114, 2557, 2961, 4011, 4026, 4240, 4319], 'show': [707, 1065, 1728, 2122, 3181], 'lesions."The': [710], 'too,': [712], 'seems': [713, 2000, 4224], 'major': [717, 895, 1143, 4205], 'site': [718], 'action': [720], 'arsenic.': [723, 1653, 3344, 3384, 4411], '"Lung': [724], 'main': [728], 'arsenic-related': [731, 1376, 4218], 'death,"': [732], 'Allan': [734], 'Smith,': [735, 3769], 'Health': [740, 975, 1380, 1467], 'Effects': [741, 978], 'Program': [743, 2051], 'Public': [748, 1466], 'Health,': [749], 'California,': [752], 'Berkeley.': [753], '"But': [754], "we're": [755], 'seeing': [757], '[lung]': [760], 'tenfold': [765], '[increase': [766], 'the]': [768], 'rate': [769, 3481], 'bronchiectasis': [771], 'India."The': [778], 'prevalence': [779], 'manifestations': [785], 'highly': [790], 'variable': [791], 'one': [793, 2016, 2226, 2343, 3267], 'country': [794, 3578], 'next.': [797], 'For': [798, 906, 1903, 3529, 4050], 'example,': [799, 1904, 2914, 3530, 4051], 'whereas': [800, 4133], 'pigmentation': [802], 'hyperkeratosis': [804], 'indicators': [807], 'India': [819], 'see': [821, 2644, 3126, 4274], 'respiratory': [822], 'stress,': [823, 1879], 'polyneuropathy,': [824], 'vascular': [827], 'disease': [828, 4055, 4219], 'habitual': [831], 'ingestion': [832, 2967, 3649], 'water.': [836, 1007, 1309, 1701, 2752], 'This': [837, 1221, 2013, 2171, 3448, 4412], 'remains': [839], 'very': [841, 3474, 3534, 3919, 4276], 'active': [842, 3289], 'area': [843, 1317, 1491, 1601], 'epidemiologic': [845, 1120, 3722, 3906, 3948, 4340], 'research.A': [846], 'World': [847, 1379], 'ExposedGlobally,': [848], 'millions': [849, 4460], 'exposure.': [861, 941, 1147, 1946, 2310, 2444, 2944, 3084, 3211, 3566], 'The': [862, 893, 1108, 1514, 1636, 2084, 2849, 3151, 3464, 3661], 'majority': [863], 'harmful': [865, 3871], 'wells': [873, 1274, 1447, 1661], 'drilled': [874, 1263], 'through': [875, 901, 1078, 1211, 1860], 'arsenic-bearing': [876], 'sediments.': [877], 'Drinking': [878, 3763, 4267], 'contains': [880, 3654], 'primarily': [881, 923], 'inorganic': [882, 958, 1765, 2112, 2253, 3692], 'acutely': [887, 1773], 'toxic': [888, 1857, 2955, 3172], 'organic': [891, 924, 1780, 1833], 'form.': [892], 'sources': [896], 'food,': [902, 918], 'soil,': [903], 'air.': [905], 'people,': [908, 3753], 'fact,': [910], 'primary': [912, 1697], 'dietary': [920, 1507, 3069, 3113], 'includes': [922], 'forms,': [925], 'relatively': [928, 3010], 'nontoxic': [929], 'contribute': [931], 'little,': [932], 'if': [933, 3359, 3364, 3588, 3613, 4105], 'any,': [934], 'overall': [937], 'associated': [939, 1631, 2552, 3646, 3912, 4507], '(Unless': [942], 'otherwise': [943], 'indicated,': [944], 'mentions': [946], 'remainder': [951], 'refer': [955], 'form.)Rebecca': [959], 'Calderon,': [960], 'chief': [961, 2622], 'Epidemiology': [964], 'Biomarker': [966], 'Branch': [967], 'Protection': [971, 3627], 'Agency': [972], '(EPA)': [973], 'National': [974, 2630, 3757], 'Laboratory,': [980], 'preparing': [983], 'foods': [984, 1533], 'arsenic-containing': [986], 'increases': [988, 1761], 'content': [991, 1017, 2515], '10–30%': [993], 'foods,': [996], '200–250%': [999], 'beans': [1001], 'grains,': [1003], 'absorb': [1005], 'cooking': [1006], 'Moreover,': [1008], 'irrigation': [1010], 'can': [1012, 1054, 2932, 3495], 'substantially': [1013, 4330], 'increase': [1014, 2835, 3439], 'rice': [1019], 'vegetables,': [1021], 'several': [1026, 1809, 3390, 4377], 'studies': [1027, 1283, 2283, 2312, 2778, 3270, 3499, 3787, 4169], 'Southeast': [1029, 4465], 'Asia,': [1030], 'February': [1033], 'Chemosphere': [1035], 'report': [1036, 1461, 3760], 'crops': [1040], 'soil.Soil-': [1042], 'waterborne': [1044, 1242], 'does': [1046, 1848, 1979, 2578, 2947], 'readily': [1048], 'permeate': [1049], 'soil': [1053], 'key': [1057, 4019, 4228], 'source': [1058, 1144, 1698], 'young': [1062], 'children': [1063, 3155, 3185, 3222, 3246, 3292, 3546], 'significant': [1066, 1187, 1332, 3562, 4143], 'hand-to-mouth': [1067], 'activity.': [1068], 'exposed': [1072, 1165, 1302, 2844, 2872, 3291, 3296, 3544, 3582], 'sporadic': [1076], 'basis': [1077], 'hodgepodge': [1080], 'human': [1082, 2068, 2102, 2488], 'activities,': [1083], 'burning': [1087, 1481], 'fossil': [1089], 'fuels,': [1090], 'waste': [1091], 'incineration,': [1092], 'smelting': [1093], 'ores,': [1095], 'pesticide': [1096], 'herbicide': [1098], 'use,': [1099], 'coal': [1100, 1500, 1515], 'burning,': [1101], 'semiconductor': [1102], 'production,': [1103], 'manufacturing': [1106], 'processes.': [1107], 'public': [1109], 'impact': [1111, 3358], 'exposures': [1114, 2422, 3353, 3461, 3736, 3915, 4351], 'largely': [1116], 'unknown': [1117], 'focus': [1121, 3595, 4482], 'via': [1126, 1868, 2517], 'water.For': [1128], 'U.S.': [1130, 3696], 'citizens': [1131], 'piped': [1135], 'systems,': [1137, 3094], 'Nonetheless,': [1148], 'areas': [1151, 1392, 1557, 2306, 4057, 4424], 'West,': [1154], 'Midwest,': [1155], 'Southwest,': [1156], 'Northeast,': [1158], 'levels': [1168, 1276, 1306, 2399, 2501, 2963, 3209, 3585, 3656, 3744, 3937], 'ranging': [1169], '90': [1173], 'μg/L,': [1174, 1456, 3702], 'above': [1176], "EPA's": [1178, 4253], 'guideline': [1179, 3679], '10': [1181, 1666, 3667, 3701, 3714, 3738], 'μg/L.': [1182, 1667, 3682, 3739], 'To': [1183, 4294], 'date,': [1184, 4295], 'statistically': [1186], 'relationships': [1188, 2059], 'between': [1192, 2075, 2683, 3956, 4279], 'areas.The': [1199], 'situation': [1200, 1222], 'radically': [1207], 'different:': [1208], 'naturally': [1213], 'contaminated': [1214], 'groundwater': [1215, 1333, 1401, 1694, 3005], 'widespread': [1217], 'often': [1219], 'excessive.': [1220], 'began': [1223], '1970s,': [1226], 'United': [1229, 2407], 'Nations': [1230], "Children's": [1231], 'Fund,': [1232], 'response': [1234, 1943, 4161, 4403], 'epidemics': [1236], 'cholera,': [1238], 'dysentery,': [1239], 'infectious': [1243], 'diseases,': [1244, 1377, 3892], 'spearheaded': [1245], 'effort': [1247], 'switch': [1249], "region's": [1251], 'surface': [1255], 'waters': [1256], 'groundwater.': [1258], 'Millions': [1259], 'tube-wells': [1261], 'were': [1262, 2863, 3374, 3543, 3791, 4107, 4128, 4131, 4157], 'into': [1264, 3131], 'arsenic-rich': [1265, 1483, 1586], 'sediments;': [1266], 'reach': [1277], '500–1,000': [1278], 'μg/L': [1279, 3668, 3715], 'even': [1281, 3203, 3808], 'higher.Field': [1282], 'living': [1289], 'vast': [1292], 'geological': [1293], 'zone': [1294], 'Ganga-Meghna-Brahmaputra': [1298], 'plain': [1299], 'being': [1301, 1534, 2097, 3087], 'high': [1304, 2308, 2735, 2962, 3475, 3480, 3535, 3584, 4063, 4099], 'large': [1311, 1650, 3559, 3784], 'portion': [1312], 'plain,': [1315], 'totaling': [1318], '500,000': [1319, 1706], 'square': [1320], 'kilometers': [1321], 'spanning': [1323], 'shows': [1331], 'contamination,': [1335, 1402], 'putting': [1336], 'million': [1340, 1407], 'poisoning,': [1347], 'Chakraborti.': [1349], 'He': [1350, 3071, 3550, 3778, 4032], 'alarming': [1353, 3456], 'estimates': [1354, 1412], 'Environment': [1364], 'Monitoring.': [1365], 'With': [1366, 4457], '80%': [1367], 'Bangladeshis': [1369], 'estimated': [1370, 1428], 'Organization': [1381], '(WHO)': [1382], 'labeled': [1384], '"the': [1386], 'worst': [1387], 'mass': [1388], 'history."Large': [1391], 'China': [1394, 1469, 1549, 1565], 'face': [1396], '3': [1406], 'affected,': [1409], 'based': [1410, 2463], 'Toxicology': [1419, 2050, 2817, 3401], 'Applied': [1421, 2819, 3403], 'Pharmacology.': [1422], 'Shanxi': [1424], 'Province': [1425], 'alone,': [1426], '900,000': [1429], 'arsenicosis.': [1435, 1494], 'investigated': [1438], 'villages': [1439], 'Shanxi,': [1441], 'average': [1443], '52%': [1445], 'give': [1448], 'concentrations': [1452, 1651, 1664, 2749], 'higher': [1453], 'according': [1457, 2977, 3754], 'Medical': [1470], 'Shenyang.A': [1473], 'unique': [1474, 2294, 4402, 4415], 'type': [1475, 2191], 'resulting': [1478, 1523, 2924], 'coal,': [1484], 'Guizhou': [1488, 1495], 'Province,': [1489], 'endemic': [1493, 1556, 4065], 'inhabitants': [1496], 'commonly': [1497], 'cooking,': [1502], 'heating,': [1503], 'drying': [1505], 'staples': [1508], 'corn': [1510], 'hot': [1512], 'peppers.': [1513], 'burned': [1517], 'open': [1519], 'stoves': [1520], 'without': [1521, 2761], 'chimneys,': [1522], 'contamination': [1525, 1605, 3635, 4067, 4442], 'indoor': [1529], 'air': [1530], 'prepared.': [1535], 'At': [1536, 1654, 2413, 2877], 'time,': [1538, 2379, 2416, 3829], 'arsenicosis': [1539, 1563, 2920], 'affect': [1543, 2933], 'eight': [1544], 'provinces,': [1545], 'studied,': [1553], 'new': [1555], 'continuously': [1559], 'emerging.': [1560], 'Reports': [1561], 'actually': [1566, 2236], 'preceded': [1567], 'overlooked': [1576], 'due': [1577, 3254, 3965, 4000], 'limited': [1579, 4392], 'scientific': [1580, 3893], 'exchange': [1581], 'publication.Other': [1583], 'countries': [1584, 3002, 3621, 3676], 'groundwaters': [1587], 'Argentina,': [1589], 'Chile,': [1590], 'Mexico,': [1591, 2289], 'Cambodia,': [1592], 'Vietnam,': [1593], 'Thailand,': [1594], 'Nepal,': [1595, 1673], 'Ghana.': [1597], 'Obuasi': [1600, 1622], 'Ghana,': [1603], 'food': [1607], 'gold-mining': [1614], 'activities.': [1615], 'Much': [1616, 3626], 'gold': [1619, 1640], 'mines': [1623], 'locked': [1625], 'pyrite': [1627], 'arsenopyrite,': [1629], 'sulfur.': [1635], 'extraction': [1637], 'results': [1641], 'release': [1644], 'airborne': [1646], 'particles': [1647], 'least': [1655, 2595], '10%': [1656], "Ghana's": [1658], 'rural': [1659], 'borehole': [1660], 'exceeding': [1665], 'Terai': [1670, 1709], 'region': [1671], 'inhabited': [1674], 'half': [1676, 3466], "country's": [1678], 'total': [1679], 'population,': [1680, 2129], 'hundreds': [1681, 4458], 'thousands': [1683], 'shallow': [1685], 'tubewells': [1686], 'installed': [1689], 'various': [1691, 2139, 3967], 'agencies,': [1692], 'According': [1702], 'water,': [1719], 'up': [1721, 3182], '20': [1725, 3407], 'indicative': [1731], 'arsenicosis.The': [1733], 'Arsenic–Cancer': [1734], 'EquationToday,': [1735], 'researchers': [1736, 1776], 'world': [1739, 3790], 'racing': [1741], 'against': [1742, 2953, 4312], 'clock': [1744], 'unravel': [1746], 'secrets': [1748], 'workings,': [1751], 'how': [1753, 2229, 2437], 'influences': [1755], 'process': [1758], 'thereby': [1760], 'risk.': [1763, 2239], 'Although': [1764], 'generally': [1768], 'held': [1769], 'toxic,': [1774], 'some': [1775, 2148, 2222, 2597, 2608, 3068, 3263, 3818], 'argue': [1777, 3819], 'metabolites': [1781, 1834, 2089, 2119, 2140, 2156, 2317, 3326], 'ultimate': [1787], 'carcinogens.': [1788], 'metabolites,': [1792], 'DMA,': [1793], 'rodents': [1798, 4381], 'induce': [1800], 'bladder': [1801, 3501], 'promote': [1805, 2592], 'tumor': [1806, 2011], 'growth': [1807], 'organs.': [1811], 'review': [1813], 'focusing': [1815], 'induced': [1817], 'disturbances': [1818], 'calcium': [1820], 'homeostasis,': [1821], 'genomic': [1822], 'apoptotic': [1825], 'death': [1827], 'caused': [1828], 'appears': [1835, 2585, 4397], 'EHP.There': [1842], 'general': [1844], 'agreement': [1845], 'directly': [1850, 4191], 'interact': [1851], 'DNA,': [1853], 'occur': [1859], 'indirect': [1861, 1931], 'alteration': [1862], 'gene': [1864, 3488, 4091], 'expression,': [1865], 'perturbation': [1870], 'DNA': [1872, 1876, 1912], 'methylation,': [1873], 'inhibition': [1874], 'repair,': [1877, 1913], 'oxidative': [1878, 1908], 'altered': [1881], 'modulation': [1882], 'signal': [1884], 'transduction': [1885], 'pathways.': [1886, 4164], 'Many': [1887], 'mechanisms': [1890, 2021], 'overlapping,': [1892], 'interdependent,': [1893], 'heavily': [1895], 'influenced': [1896], 'factors': [1898, 2590], 'cellular': [1901], 'environment.': [1902], 'promotes': [1906], 'stress': [1909, 4160], 'impaired': [1911], 'yet': [1915, 2227], 'tend': [1920], 'amplify': [1922], 'mutation': [1923], 'rates,': [1924], 'thus': [1925, 2105], 'increasing': [1926], 'likelihood': [1928], 'cancer.Another': [1930], 'mechanism': [1932], 'influence': [1935], 'growth-stimulating': [1937], 'chemicals': [1938], 'cytokines': [1940, 1977, 1989], 'generated': [1941], 'Dori': [1947], 'Germolec,': [1948], 'research': [1950, 2979, 3907, 4209, 4341], 'scientist': [1951], 'NIEHS': [1954], 'Laboratory': [1955, 2633], 'Molecular': [1957, 2047], 'Toxicology,': [1958], 'approaching': [1961], 'question': [1964, 2244, 3836], 'standpoint': [1967], 'cytokine': [1969], 'biology.': [1970], '"Arsenic': [1971], 'alters': [1972], 'production': [1974], 'inflammatory': [1976], 'persistently': [1981], 'over': [1982, 2903], 'time,"': [1983], 'Germolec': [1984], 'says.': [1985, 3299], '"These': [1986], 'seem': [1990, 2949], 'relate': [1992], 'skin.': [1998], 'stimulate': [2002], 'progenitor': [2003], 'cells': [2004], 'could': [2006, 2386, 3433, 3615], 'ultimately': [2007], 'responsible': [2009], 'formation.': [2012], 'just': [2015, 3045], 'number': [2019, 4124], 'plausibility."': [2025], 'Toby': [2036], 'Rossman,': [2037], 'environmental': [2039, 4451], 'science': [2040], 'professor': [2041, 2273, 2479], 'Genetic': [2049], 'New': [2053, 2285, 2545, 2782, 4203], 'York': [2054], 'University,': [2055], 'animal': [2061, 4384], 'models': [2062, 2601], 'cultured': [2067], 'cells.Studies': [2069], 'differences': [2071, 3256], 'metabolism': [2074, 2235, 4223], 'individuals': [2076, 2130], 'led': [2078, 2831], 'further': [2080, 2082, 3978], 'insights—and': [2081], 'questions.': [2083], 'importance': [2085, 4183], 'individual': [2087, 2197, 2433, 2470], 'terms': [2091], 'induction': [2094], 'determined.': [2098], 'All': [2099], 'populations': [2103, 3560], 'studied': [2104], 'far': [2106], 'methylate': [2111], 'patterns': [2116, 4047, 4053, 4074], 'urine': [2121, 2298, 2367], 'substantial': [2123], 'interindividual': [2124, 2231, 2332], 'variation.': [2125], 'Within': [2126], 'any': [2127, 3577], 'given': [2128], 'differ': [2131], 'quantity': [2134], 'distribution': [2136], 'excreted': [2143], 'kidney.': [2146], 'If': [2147, 2353, 3040, 3191], 'happen': [2149], 'excrete': [2151], 'carcinogenic': [2155, 2418, 2801, 2896, 3381, 4231, 4314], 'unable': [2159], 'metabolize': [2161], 'efficiently,': [2163], 'they': [2164, 2461, 2821, 3187, 3593, 4106], 'cancer.': [2170], 'variation': [2172, 2232, 2333], 'affected': [2175, 4463], 'factors,': [2180], 'dose': [2182, 4100], 'level,': [2183], 'route(s)': [2184], 'diet,': [2187], 'particular': [2190, 4281], 'exposed.': [2199], 'Polymorphisms': [2200], 'genes': [2202, 4126, 4152], 'code': [2204], 'enzymes': [2207], 'metabolism,': [2210, 3258, 3319], 'methyltransferase,': [2214], 'implicated': [2218], 'accounting': [2220], 'variability.No': [2225], 'knows': [2228], 'affects': [2237], '"This': [2240, 3432], 'difficult': [2243, 4244], 'since': [2245], 'you': [2247, 2255, 2642], 'deal': [2248], 'carcinogenicity': [2251], 'dealing': [2257], 'six': [2259], 'distinct': [2262], '[metabolites],"': [2263], 'H.': [2265], 'Vasken': [2266], 'Aposhian,': [2267], 'molecular': [2269, 4429], 'biology': [2272], 'Arizona.': [2278], 'Aposhian': [2279], 'involved': [2281, 4145], 'England,': [2286], 'Mongolia,': [2287], 'Romania,': [2288], 'Kazakhstan': [2291], 'identify': [2293, 2388, 3378], 'abnormal': [2296], 'profiles': [2299], 'Once': [2311], 'reveal': [2313], 'promoters': [2319], 'and/or': [2320], 'carcinogens,': [2321], 'will': [2323, 3699, 3771, 4237, 4342], 'possible': [2325, 3926], 'better': [2327], 'answer': [2328, 3834], 'riddle': [2330], 'vulnerability': [2335], 'effects.The': [2338], 'metabolite': [2339], 'MMAIII': [2340, 2354], 'presently': [2341], 'candidates': [2347], 'potential': [2350, 2375, 3217, 3382, 4439], 'inducer.': [2352], 'turns': [2355], 'out': [2356, 2496, 2996, 4234], 'carcinogenic,': [2359], 'increased': [2361, 2549, 2693, 3062, 3219, 3803, 4129], 'decreased': [2363], 'amount': [2364], 'might': [2368], 'prove': [2369, 3773], 'useful': [2370], 'marker': [2373, 2506], 'future': [2376, 4208], 'arsenic-mediated': [2377], 'cancer.In': [2378], 'identification': [2381], 'reliable': [2383], 'markers': [2385, 2486], 'help': [2387, 2493, 2951, 3725], 'groups': [2389], 'susceptible': [2394, 2705, 3161, 3251, 3987, 4013], 'typically': [2403], 'States': [2408], '(less': [2409], 'μg/L).': [2412], 'present': [2415], 'unclear.': [2424], 'Biomarkers': [2425], 'provide': [2427, 3830], 'detailed': [2430], 'picture': [2431], 'body': [2439], 'responding': [2441], '"The': [2445], 'low-dose': [2446], 'extrapolations': [2447], 'assessment': [2451], 'purposes': [2452], 'subject': [2455], 'error': [2457], 'part': [2459, 4406], 'because': [2460, 3477], 'ecologic': [2466], 'data': [2467, 3723, 3832, 3979], 'measures': [2471], 'exposure,"': [2473], 'Margaret': [2475], 'Karagas,': [2476], 'epidemiology': [2478, 3770], 'College.': [2482], '"Use': [2483], 'relevant': [2485, 4192], 'tissue': [2489], 'samples': [2490], 'eventually': [2491, 3794], 'us': [2494], 'sort': [2495], 'lower': [2500, 3657, 4078], 'exposure."One': [2503], 'practical': [2504], 'identified': [2507, 3312, 4301], 'Karagas': [2509], 'toenail': [2511], 'clippings,': [2512], 'measured': [2516], 'instrumental': [2518], 'neutron': [2519], 'activation': [2520, 4146], 'analysis.': [2521], 'Using': [2522], 'measure,': [2524], 'she': [2525, 3972], 'her': [2527], 'Cancer': [2536, 2631, 3740], 'Causes': [2537], '&': [2538], 'Control': [2539], 'case–control': [2542], 'Hampshire': [2546], 'suggesting': [2547], 'moderate': [2554, 4177], 'smokers.An': [2560], 'Emerging': [2561], 'Consensus:': [2562], 'Does': [2564], 'Not': [2565, 2945], 'Act': [2566], 'AloneStudies': [2567], "Karagas's": [2570], 'point': [2571, 4196, 4287], 'growing': [2574], 'recognition': [2575], 'operate': [2581], 'alone.': [2582, 2848, 2876], 'Rather,': [2583], 'work': [2587], 'target': [2598], 'sites.': [2599], '"Animal': [2600], 'indicate': [2602], 'takes': [2604], 'promoter': [2606], 'genotoxic': [2609], 'carcinogen': [2610], 'get': [2612], 'produce': [2615], 'cancers,"': [2617], 'Michael': [2619], 'Waalkes,': [2620], 'section': [2621], 'Inorganic': [2625], 'Carcinogenesis': [2626, 4255], 'Section': [2627], 'Institute': [2632, 3029], 'Comparative': [2635, 2884], 'Carcinogenesis,': [2636], 'housed': [2637], 'NIEHS.': [2640], '"When': [2641], 'kind': [2646], 'cotreatment': [2648], 'effect,': [2649], 'makes': [2651], 'harder': [2653], 'nail': [2655], 'down': [2656], 'precise': [2658], 'contribution': [2659], 'final': [2664], 'tumor."The': [2665], 'classic': [2666], 'cofactor': [2667], 'regard': [2670], 'tobacco': [2673], 'smoke.': [2674], '"There': [2675], 'mounting': [2677], 'malignant': [2681, 3527], 'synergy': [2682], 'smoking': [2684], 'arsenic,"': [2686, 4373], 'Smith.': [2688], '"Smokers': [2689], 'comprise': [2703], 'subpopulation."': [2706], 'Smith': [2710, 3053, 3567], 'colleagues,': [2712], 'November': [2716], '2000': [2717], 'relative': [2724], 'lung': [2727, 2756, 3503, 3536, 3806], 'Chileans': [2730], 'smoked': [2732], 'had': [2734, 3801, 4391], '32': [2741], 'nonsmokers': [2745, 3797], 'contrast,': [2754], 'smokers': [2760, 3800], 'nonsmokers.': [2772], 'Similar': [2773], 'findings': [2774, 4321], 'come': [2776], 'Taiwan': [2780], 'Hampshire.Other': [2783], 'cofactors': [2784, 2918], 'gaining': [2787], 'attention.': [2788], "Rossman's": [2789], 'group': [2790], 'among': [2792, 4447], 'first': [2794, 3376, 3465], 'hypothesize': [2796], 'requires': [2799], 'partner—in': [2802], 'another': [2809], 'Pharmacology,': [2820], 'finding': [2823, 3388], 'plus': [2826, 2856], 'ultraviolet': [2827], '(UV)': [2828], 'radiation': [2829], 'dose-related': [2834], 'mice': [2840, 2843, 2852, 2871, 3418], 'compared': [2841], 'UV': [2846, 2857, 2874], 'light': [2847, 2858, 2875], 'tumors': [2850], 'treated': [2853], 'arsenite': [2855], 'appeared': [2860], 'earlier': [2861], 'larger': [2864, 3825], 'invasive': [2867], 'Third': [2880], 'International': [2881], 'Conference': [2882], 'Physiology': [2885], 'Biochemistry,': [2887], 'Rossman': [2888], 'selenium': [2891, 2927, 2948], 'deficiency': [2892, 2925], 'enhanced': [2894], 'arsenic.Such': [2899], 'insights': [2900], 'carry': [2902], 'epidemiological': [2906], 'realm.': [2907], 'malnutrition': [2922], '(with': [2923], 'nutrients': [2930], 'metabolism)': [2935], 'agricultural': [2937], 'activities': [2938], 'lead': [2940, 3434, 3496], 'frequent': [2942], 'sun': [2943], 'protect': [2952], 'accelerate': [2972], 'excretion': [2974], 'selenium,': [2976], '5': [2983], 'May': [2984, 3408], 'Science': [2988], 'Total': [2991], 'Environment."We': [2992], 'need': [2993, 3033, 3976, 4272, 4470], 'find': [2995], 'whether': [2997, 3838], 'poverty-stricken': [3001], 'arsenic-tainted': [3004], 'benefit': [3007], 'cheap': [3011, 3037], 'strategy': [3012], 'supplementing': [3014], 'diet': [3016], 'selenium,"': [3018], 'Floyd': [3020], 'Frost,': [3021], 'epidemiologist': [3023], 'Lovelace': [3026], 'Respiratory': [3027], 'Albuquerque.': [3031], 'solutions': [3034], 'doable.': [3039], "you're": [3041], 'Bangladesh,': [3043, 3276], 'there': [3044, 3509, 3639, 3839, 3884], "isn't": [3046], 'much': [3047, 3641], 'money': [3048], 'expensive': [3050], 'mitigation': [3051, 4474], 'strategies."However,': [3052], 'notes': [3054, 3551], 'he': [3056, 3298, 3531, 4117], 'modest': [3061], 'risks': [3063, 3538, 3741, 3775], 'deficiencies.': 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