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'Google': [32, 63, 92, 119, 245, 285, 360, 402, 422, 603, 698, 748, 761, 835, 882, 915, 947, 1013, 1036, 1063, 1081, 1118, 1149, 1174, 1228, 1258, 1291, 1369, 1451, 1501, 1551, 1591, 1617, 1636, 1840, 1885, 1904, 1921, 1973, 1994, 2065, 2083, 2135, 2196, 2223, 2271, 2327, 2390, 2515, 2540, 2584, 2611, 2648, 2686, 2723, 2764, 2783, 2872, 2897, 2915, 2945, 2976, 2993, 3014, 3065, 3155, 3176, 3234, 3412, 3459, 3538, 3631, 3656, 3681, 3704, 3741, 3766, 3781, 3820, 3839, 3864, 3903, 3924, 3956, 3988, 4012, 4039, 4062, 4092, 4140, 4180, 4205, 4237, 4250, 4300, 4313, 4357, 4382, 4405, 4430, 4505, 4530, 4559, 4584, 4705, 4737], 'Scholar).': [33, 93, 246, 286, 361, 423, 604, 699, 762, 836, 883, 948, 1014, 1082, 1150, 1229, 1370, 1502, 1552, 1841, 1922, 1995, 2084, 2136, 2224, 2272, 2391, 2516, 2541, 2585, 2612, 2687, 2724, 2784, 2916, 2946, 3015, 3066, 3177, 3235, 3413, 3460, 3539, 3705, 3782, 3865, 3957, 4093, 4141, 4181, 4206, 4251, 4431, 4531, 4585, 4738], 'These': [34, 625, 1923, 3067, 3350], 'proteins,': [35, 626, 653, 712], 'which': [36, 992, 1186, 1195, 1260, 1327, 1390, 1925, 2420, 2697, 3542, 4681], 'belong': [37], 'to': [38, 66, 76, 254, 342, 550, 554, 622, 633, 811, 846, 964, 995, 1088, 1121, 1125, 1157, 1239, 1313, 1330, 1338, 1455, 1524, 1555, 1658, 1674, 1684, 1689, 1702, 1715, 1744, 1802, 1861, 2006, 2036, 2107, 2113, 2161, 2246, 2276, 2286, 2349, 2410, 2446, 2484, 2561, 2701, 2800, 2807, 2924, 3051, 3186, 3259, 3325, 3375, 3382, 3501, 3580, 3599, 3686, 3691, 3716, 3968, 4068, 4114, 4124, 4219, 4440, 4446, 4456, 4610, 4618, 4643, 4663, 4715, 4741, 4777], 'bZIP': [40, 2164], 'group': [41, 929, 1048, 1563], 'DNA': [43, 512, 529, 659, 723, 1131, 1379, 1394, 1807, 1929, 2039], 'binding': [44, 160, 172, 193, 205, 438, 455, 478, 495, 513, 530, 660, 724, 982, 1132, 1380, 1808, 1930, 2040, 2147, 2160, 2549, 2705, 3183, 3369], 'proteins': [45, 616, 1337, 1351, 1655, 1785, 3339, 4795], '2Johnson': [50], 'P.F.': [51], 'McKnight': [52], 'S.L.': [53], 'Annu.': [54], 'Rev.': [55], 'Biochem.': [56, 824, 904, 1002, 1163], '1989;': [57, 1363], '58:': [58], '799-839Crossref': [59], '(829)': [62], 'Scholar),': [64, 120, 916, 1037, 1175, 1259, 1292, 1452, 1592, 2328, 2649, 3682, 4063, 4314], 'associate': [65], 'form': [67, 618, 645, 1339, 1765], 'variety': [69], 'homo-': [71], 'heterodimers': [73, 647, 656, 1466], 'that': [74, 129, 302, 311, 322, 509, 569, 620, 671, 767, 899, 925, 956, 1296, 1342, 1557, 1649, 1780, 2092, 2152, 2167, 2330, 2452, 2730, 2738, 2819, 2857, 3071, 3091, 3246, 3565, 3591, 3724, 4151, 4330, 4444, 4616, 4749, 4773, 4789], 'bind': [75, 621, 994, 2238, 3383], 'common': [78], 'site(1Angel': [79], 'First': [94, 612], 'identified': [95, 2155], 'by': [96, 133, 257, 519, 852, 892, 923, 976, 998, 1043, 1185, 1304, 1349, 1430, 1464, 1468, 1809, 1814, 1934, 2095, 2156, 2170, 2367, 2373, 2413, 2419, 2523, 2543, 3094, 3122, 3250, 3270, 3285, 3300, 3340, 3608, 3714, 3795, 4273, 4635, 4654, 4680, 4711], 'its': [97, 215, 248, 552, 1123, 1130, 1202, 1409, 1513, 1803, 1855, 1859, 2159, 2228, 2244, 2477, 2486, 3289, 3431, 3511, 4216, 4661], 'role': [98, 368], 'in': [99, 291, 374, 527, 630, 809, 819, 844, 962, 984, 1152, 1209, 1237, 1322, 1374, 1537, 1663, 1697, 1700, 1739, 2303, 2408, 2431, 2591, 2805, 2927, 3032, 3076, 3198, 3254, 3309, 3575, 3583, 3596, 3869, 3966, 4144, 4215, 4276, 4315, 4689, 4721, 4808], 'human': [100, 572, 3373], 'metallothionein': [101], 'IIA': [102], 'gene': [103, 131, 574], 'regulation(3Lee': [104], 'W.': [105, 4165], 'Haslinger': [106], 'A.': [107, 732, 1053, 1108, 1269, 1271, 1479, 1486, 1978, 1982, 2043, 2045, 2313, 2626, 2633, 2663, 2673, 2875, 2877, 2998, 3002, 3139, 3143, 3169, 3218, 3222, 3634, 3636, 3744, 3746, 3771, 3798, 3800, 3908, 3912, 3991, 3993, 4032, 4071, 4073, 4195, 4225, 4288, 4336, 4338, 4408, 4410, 4484, 4486, 4508, 4510, 4562, 4564], 'Tjian': [110], 'R.': [111, 222, 580, 822, 902, 1000, 1024, 1066, 1070, 1134, 1138, 1161, 1216, 1279, 1477, 1598, 2053, 2624, 2654, 2665, 2713, 2756, 2885, 3400, 3447, 3526, 3644, 3754, 3808, 3944, 4726], 'Nature.': [112, 754, 1056, 1111, 1878, 1897, 1914, 2189, 2216, 2264, 2383, 2577, 2757, 2776, 2865, 2969, 3058, 3674, 3697, 3734, 3774, 3832, 3857, 4133, 4375], '1987;': [113, 236, 594], '325:': [114], '368-372Crossref': [115], '(484)': [118], 'was': [122, 252, 1086, 1769, 2111, 2153, 2481, 2727, 3377, 3380, 3499], 'also': [123, 1233, 1302, 1727, 2301, 2521, 2546, 3019, 3257, 4066, 4208], 'found': [124, 253, 2005, 3381], 'as': [125, 300, 772, 858, 1214, 1242, 1706, 1864, 2469, 3097, 3117, 3573], 'transcription': [127, 166, 199, 447, 487, 556, 635, 778, 799, 958, 1863, 2165, 4658, 4685, 4761, 4784], 'factor': [128, 436, 448, 476, 488, 990, 1709, 2166, 4659, 4686], 'mediates': [130, 841, 889, 921, 1234, 3182], 'induction': [132, 292, 808, 843, 891, 922, 1236, 2801, 3034], 'phorbol': [135, 3612, 3692], 'ester': [136], 'tumor': [137, 1707, 3720], 'promoter': [138, 564, 1402], '12-O-tetradecanoylphorbol-13-acetate': [139], '(TPA)': [140], 'hence': [142], 'name': [144], 'TRE1': [145], '1The': [146, 179], 'abbreviations': [147, 180], 'used': [148, 181, 4710], 'are:': [149, 182], 'TRETPA': [150, 183], '(12-O-tetradecanoylphorbol-13-acetate)': [151, 184, 425, 465], 'response': [152, 156, 170, 185, 189, 203, 212, 426, 432, 453, 466, 472, 493, 810, 839, 845, 886, 963, 979, 1100, 1238, 1701, 2409, 2806, 3967, 4662], 'elementMAPKmitogen-activated': [153, 186], 'protein': [154, 187, 371, 429, 439, 456, 469, 479, 496, 786, 863, 868, 931, 1522, 2003, 2096, 2148, 2151, 2171, 2441, 4682, 4781], 'kinaseSREserum': [155, 188], 'elementTCFternary': [157, 190], 'complex': [158, 191, 435, 475, 540, 989, 1094], 'factorCBPCREB': [159, 192], 'proteinJAKJanus': [161, 194], 'kinaseERKextracellular': [162, 195], 'stimulus': [163, 196, 443, 483, 969], 'responsive': [164, 197, 444, 484], 'kinaseATFactivating': [165, 198], 'factorJNKJun': [167, 200], 'N-terminal': [168, 201, 450, 490, 2010, 2021, 2229, 2296, 2478], 'kinaseCREBcAMP': [169, 202], 'element': [171, 204, 427, 433, 454, 467, 473, 494, 840, 887, 3562], 'proteinFRKFos': [173, 206], 'regulating': [174, 207, 458, 498], 'kinaseMEKMAPK': [175, 208], 'or': [176, 209, 328, 461, 501, 523, 856, 866, 1298, 1906, 1946, 2284, 2370, 2552, 2853, 3088, 3719, 3926, 4324], 'ERK': [177, 210, 462, 502, 1047, 1187, 1267, 1310, 3709, 4099, 4115, 4592], 'kinase.': [178, 463, 503], 'kinase.(TPA': [211], 'element)': [213], 'for': [214, 565, 607, 1393, 1771, 2117, 2466, 2695, 3209, 3486, 3491, 3727, 4186, 4591, 4766, 4817, 4829], 'recognition': [216], 'site(4Angel': [217], 'Imagawa': [219, 577], 'Chiu': [221, 579], 'Stein': [223, 581, 2666], 'B.': [224, 582, 728, 1275, 1566, 1574, 1626, 1890, 1948, 1956, 2049, 2490, 2498, 2530, 2601, 2667, 2881, 2935, 2983, 3390, 3396, 3437, 3443, 3516, 3522, 3640, 3750, 3804, 3878, 3886, 3934, 3940, 3999, 4079, 4344, 4385, 4492, 4539, 4827], 'Imbra': [225, 583], 'R.J.': [226, 584, 1580, 1628, 1962, 2504, 2532, 2603, 2937, 2985, 3892, 4001, 4081, 4346, 4395, 4397, 4494, 4549, 4551], 'Rahmsdorf': [227, 585, 1246], 'H.J.': [228, 586, 1247], 'Jonat': [229, 587], 'C.': [230, 588, 3997, 4077, 4223, 4286, 4342, 4416, 4490, 4516, 4570], 'Herrlich': [231, 589, 1252, 1483, 2630, 2674], 'Cell.': [235, 392, 593, 740, 1071, 1139, 1283, 1441, 1543, 1581, 1607, 1830, 1963, 2057, 2076, 2505, 2676, 2714, 2889, 2908, 3648, 3758, 3812, 3893, 3978, 4052, 4695, 4727], '49:': [237, 595], '729-739Abstract': [238, 596], 'Full': [239, 396, 414, 416, 597, 829, 909, 1007, 1075, 1143, 1168, 1445, 1585, 1611, 1834, 1967, 2509, 2680, 2718, 3623, 3625, 3897, 3982, 4056, 4699, 4731], 'Text': [240, 397, 415, 417, 598, 830, 910, 1008, 1076, 1144, 1169, 1446, 1586, 1612, 1835, 1968, 2510, 2681, 2719, 3624, 3626, 3898, 3983, 4057, 4700, 4732], 'PDF': [241, 398, 418, 599, 831, 911, 1009, 1077, 1145, 1170, 1447, 1587, 1613, 1836, 1969, 2511, 2682, 2720, 3627, 3899, 3984, 4058, 4701, 4733], '(2152)': [244, 602], 'Following': [247, 1015, 1553, 2225], 'discovery,': [249], 'activity': [251, 295, 514, 531, 537, 1179, 1316, 1381, 1699, 1741, 2142, 2404, 2427, 2488, 2804, 2829, 3594, 3791, 3871, 4623, 4687], 'be': [255, 298, 507, 516, 1158, 1670, 2114, 2350, 2691, 2925, 3030, 3481, 4437, 4611, 4644, 4806], 'induced': [256, 961], 'many': [258], 'other': [259, 897, 1210, 1299, 1305, 1781, 1844, 2951, 3468, 3487, 4464], 'stimuli,': [260], 'including': [261, 713], 'growth': [262, 893, 2414, 3609, 3687, 3796], 'factors,': [263, 894], 'cytokines,': [264, 895], 'T': [265, 3930], 'cell': [266, 789, 1517, 4712], 'activators,': [267], 'neurotransmitters,': [268], 'UV': [270, 1243, 1711, 3717, 3875], 'irradiation': [271, 3718, 3876], '(1Angel': [272], 'Several': [287, 803], 'mechanisms': [288, 321, 3102, 4615, 4679, 4772], 'are': [289, 610, 1199, 1207, 1301, 1343, 1638, 1656, 1757, 1786, 1932, 2000, 2734, 3018, 3073, 3110, 3297, 3304, 3353, 3470, 3604, 3711, 3725, 3872, 3964, 4184, 4596, 4641], 'involved': [290, 2926, 3031, 4807], 'may': [297, 1726, 2138, 2464, 3029, 3480], 'classified': [299], 'those': [301, 310, 1347, 3475], 'increase': [303, 1696, 1738], 'abundance': [305], 'components': [308, 770, 1756, 4798], 'stimulate': [312, 1122, 2485], 'their': [313, 631, 722, 1525, 1682, 1760, 2859, 3077, 3597], 'activity.': [314, 378, 2343], 'A': [315, 562, 837, 865, 884, 2098, 2461], 'complete': [316], 'discussion': [317], 'all': [319, 3546, 3959], 'regulate': [323], 'activity,': [325, 2450, 4473], 'either': [326, 854, 862, 1865, 2368], 'positively': [327], 'negatively,': [329], 'beyond': [331], 'scope': [333], 'this': [335, 539, 608, 950, 1456, 1650, 1764, 3104, 3180, 4657, 4760], 'minireview,': [336], 'reader': [339, 505], 'referred': [341], 'an': [343, 558, 2086, 4280], 'earlier,': [344], 'more': [345, 1182, 1344, 1461, 3483], 'comprehensive': [346], 'review(1Angel': [347], 'The': [362, 379, 504, 605, 972, 1192, 1641, 1747, 2947, 3016, 3100, 3236, 3461, 3489, 3602, 3866, 4108, 4182], 'present': [363], 'focuses': [365], 'on': [366, 721, 1266, 2855, 2949, 3571, 4118, 4462, 4471, 4656], 'mitogen-activated': [370, 428, 468], 'kinases': [372, 932, 1945, 2004, 3963, 4158, 4782], '(MAPKs)': [373], 'regulation': [375, 380, 794, 4620, 4672], 'functions': [382, 4754], 'these': [384, 655, 2822, 3307], 'important': [385, 4628, 4745], 'signal-transducing': [386], 'enzymes': [387], 'were': [388], 'recently': [389, 2482, 2728], 'reviewed(5Marshall': [390], 'C.J.': [391, 4132], '1995;': [393, 411, 1630, 2534, 2605, 2758, 2777, 2939, 2987, 3620, 3833, 4399, 4424, 4524, 4553, 4578, 4728], '80:': [394, 4729], '179-185Abstract': [395], '(4225)': [401], 'Scholar,': [403, 749, 1064, 1886, 1974, 2066, 2197, 2765, 2873, 2898, 2977, 2994, 3156, 3632, 3657, 3742, 3767, 3821, 3840, 3904, 3989, 4013, 4040, 4238, 4301, 4358, 4383, 4406, 4506, 4560], '6Cobb': [404], 'Goldsmith': [406, 3615], 'E.J.': [407, 3616], 'J.': [408, 1068, 1136, 1357, 1494, 1873, 2128, 2174, 2186, 2249, 2261, 2641, 3617, 3671, 3854, 4370, 4387, 4393, 4541, 4547], 'Biol.': [409, 741, 1284, 1544, 2058, 2075, 2890, 2907, 3618, 3649, 3759, 3813], 'Chem.': [410, 3619], '270:': [412, 3621], '14843-14846Abstract': [413, 3622], '(1659)': [421, 3630], 'TPA': [424, 464], 'kinase': [430, 441, 445, 451, 459, 470, 481, 485, 491, 499, 864, 2097, 2172, 3485, 4104, 4150, 4213, 4329, 4588], 'serum': [431, 471, 885, 978, 1099], 'ternary': [434, 474, 988, 1093], 'CREB': [437, 477, 2146, 2283], 'Janus': [440, 480], 'extracellular': [442, 482, 816, 968, 2812, 3600, 4664], 'activating': [446, 486], 'cAMP': [452, 492, 838, 855], 'MAPK': [460, 500, 1941, 2377, 4803], 'should': [506], 'aware': [508], 'although': [510, 3190], 'can': [515, 617, 2237, 2242, 2615, 2740, 4479, 4805], 'conveniently': [517], 'measured': [518, 3466], 'electrophoretic': [520], 'mobility': [521], 'shift': [522], 'footprinting': [524], 'assays,': [525], 'changes': [526], 'do': [532, 1926, 2849, 2921, 2962, 3082, 3362], 'not': [533, 954, 1813, 1927, 2232, 2365, 2429, 2850, 2922, 2963, 3083, 3194, 3240, 3268, 3283, 3298, 3354, 3363, 3471, 3549, 3690, 4267, 4535], 'mirror': [534], 'factor.': [541], 'Therefore,': [542], 'when': [543], 'dealing': [544], 'with': [545, 648, 1334, 1398, 1909, 2457, 2593, 3113, 3467, 3567, 3784, 4717], 'AP-1,': [546], 'it': [547, 952, 1293, 1383, 1459, 1777, 2650, 2726, 3559, 4265, 4270, 4317, 4435, 4455], 'critical': [549], 'measure': [551], 'ability': [553, 632, 1124, 1683, 1860, 2245], 'activate': [555, 634, 900, 926, 1126, 1558, 1685, 1730, 1862, 2247, 4480, 4536], 'AP-1-dependent': [559], 'reporter': [560], 'gene.': [561], 'useful': [563], 'such': [566, 1213, 1241], 'experiments': [567], 'collagenase': [573], '(4Angel': [575], 'reasons': [606], 'discrepancy': [609], 'several.': [611], 'foremost,': [614], 'several': [615, 710, 1021], 'complexes': [619, 3192], 'sites.': [624], 'however,': [627, 3352], 'differ': [628, 3595], 'considerably': [629, 3472, 3712], 'target': [637, 4629, 4747], 'genes.': [638], 'For': [639], 'instance,': [640], 'both': [641, 1593, 1750, 2453, 2746], 'c-Fos': [642, 665, 1721, 2309, 2341, 2363, 2425, 2846, 2854, 3053], 'Fra-1': [644, 677], 'stable': [646, 1345], 'any': [649, 719, 966, 3086], 'have': [657, 3193], 'similar': [658, 2444, 2462, 2700, 3264], 'activities': [661, 1748, 3710], 'specificities,': [663, 3585], 'yet': [664, 3195, 4642], 'has': [666, 1261, 4261, 4466, 4649], 'potent': [668], 'transactivation': [669, 1856, 2120], 'domain': [670, 1205, 2041, 2307, 2480], 'absent': [673], 'from': [674, 1425, 3474, 4112], 'smaller': [676], 'protein(7Suzuki': [678], 'T.': [679, 683, 685, 726, 751, 1273, 1353, 1438, 1572, 1576, 1600, 1819, 1829, 1888, 1911, 1954, 1958, 1980, 2047, 2122, 2182, 2257, 2317, 2380, 2496, 2500, 2862, 2879, 2966, 3000, 3055, 3141, 3220, 3274, 3388, 3435, 3514, 3638, 3665, 3694, 3731, 3748, 3802, 3848, 3884, 3888, 3910, 3932, 3975, 4167, 4171, 4173, 4389, 4543, 4692, 4824], 'Okuno': [680], 'H.': [681, 687, 689, 1051, 1106, 1473, 2620, 2659, 3769, 4412, 4512, 4566], 'Yoshida': [682], 'Endo': [684], 'Nishina': [686], 'Iba': [688], 'Nucleic': [690], 'Acids': [691], 'Res.': [692], '1992;': [693, 742, 826, 906, 1004, 1057, 1112, 1165, 1608, 2077, 2321, 2578, 2909, 3170, 3775, 4033, 4053, 4175, 4199, 4696], '19:': [694], '5537-5542Crossref': [695], '(194)': [697], 'Second,': [700], 'phosphorylation': [701, 1651, 1794, 1846, 2102, 2226, 2331, 2421, 2438, 2471, 2594, 2831, 2929, 3022, 3121, 3210, 3249, 3336, 4187, 4683], 'at': [702, 1194, 1795, 1849, 2332, 2422, 2472, 3331], 'specific': [703, 3075, 3344, 4810], 'sites': [704, 1193, 1799, 2011, 2023, 2033, 2856, 2956, 3570], 'enhances': [705], 'transactivating': [707], 'potential': [708], 'c-Jun': [714, 1521, 1594, 1678, 1717, 1745, 1810, 1848, 2025, 2091, 2140, 2236, 2285, 2299, 2852, 2958, 3185, 3214, 3245, 3296, 3376, 3420, 3429, 3498], 'c-Fos,': [716, 1326, 1773], 'without': [717, 1128], 'having': [718], 'effect': [720, 1265, 4470], 'activities(8Smeal': [725], 'Binetruy': [727, 1889], 'Mercola': [729, 1891], 'D.': [730, 1539, 1624, 2528, 2599, 2750, 2933, 2981], 'Grover-Bardwick': [731], 'Heidecker': [733], 'G.': [734, 3398, 3445, 3524, 3942, 4047, 4229, 4292], 'Rapp': [735], 'U.R.': [736], 'Mol.': [739, 1282, 1542, 2056, 2074, 2888, 2906, 3647, 3757, 3811], '12:': [743, 1496, 2643], '3507-3513Crossref': [744], '(305)': [747], '9Deng': [750], '1994;': [755, 877, 941, 1030, 1222, 1285, 1582, 1915, 1964, 2059, 2129, 2190, 2217, 2265, 2384, 2506, 2715, 2866, 2891, 2970, 3059, 3406, 3453, 3532, 3650, 3675, 3698, 3735, 3760, 3814, 3858, 3894, 3950, 4007, 4087, 4134, 4244, 4307, 4352, 4376, 4500], '371:': [756, 1916, 2385, 2867, 2971, 3060, 3699, 3736], '171-175Crossref': [757, 1917, 2386, 2868, 2972, 3061, 3700, 3737], '(318)': [760, 1920, 2389, 2871, 2975, 3064, 3703, 3740], 'Most': [763, 3557, 4666], 'genes': [766, 776, 4630, 4748], 'encode': [768], 'behave': [771], '“immediate-early”': [773], 'genes,': [774], 'i.e.': [775], 'whose': [777, 981, 2403, 4631], 'rapidly': [780, 960, 1039, 1639, 2406], 'induced,': [781], 'independently': [782], 'de': [784, 1480, 2627], 'novo': [785], 'synthesis,': [787, 2847], 'following': [788], 'stimulation.': [790, 1526], 'Among': [791], 'these,': [792], 'c-fos': [796, 807, 842, 890, 957, 1190, 1235, 1318, 1529, 3033], 'c-jun': [798, 1401, 1418, 1532, 1646, 1660, 1690, 2617], 'best': [801], 'understood.': [802], 'cis': [804, 1415], 'elements': [805], 'mediate': [806], 'diverse': [813, 2809], 'spectrum': [814], 'stimuli': [817, 898, 924, 1240, 1556, 1704, 3723], '(reviewed': [818, 4688, 4720], '10Treisman': [821], 'Trends': [823, 903, 1001, 1162], 'Sci.': [825, 905, 1003, 1164, 3166, 4029], '17:': [827, 907, 1005, 1166], '423-426Abstract': [828, 908, 1006, 1167], '(349)': [834, 914, 1012, 1173], 'neurotransmitters': [847], 'polypeptide': [849], 'hormones': [850], 'which,': [851], 'using': [853], 'Ca2+': [857], 'second': [859], 'messengers,': [860], 'activated': [861, 2169, 4272], 'calmodulin-dependent': [867], 'kinases,': [869], 'respectively(11Sheng': [870], 'M.E.': [871, 875, 2771, 3827], 'Thompson': [872], 'M.A.': [873, 2572], 'Greenberg': [874], 'Science.': [876, 940, 1629, 2533, 2604, 2938, 2986, 4006, 4086, 4174, 4198, 4230, 4243, 4293, 4306, 4351, 4398, 4423, 4499, 4523, 4552, 4577], '252:': [878], '1427-1430Crossref': [879], '(1279)': [881], '(SRE)': [888], 'MAPKs(10Treisman': [901], 'Sis-inducible': [919], 'enhancer': [920], 'JAK': [928], '(12Darnell': [933], 'Jr.,': [934, 2072, 2904], 'J.E.': [935, 2073, 2905], 'Kerr': [936], 'I.M.': [937], 'Stark': [938], 'G.R.': [939], '264:': [942], '1415-1421Crossref': [943], '(4974)': [946], 'Given': [949], 'complexity,': [951], 'surprising': [955], 'almost': [965], 'imaginable': [967], '(Fig.': [970, 1420, 2836, 4106, 4603], '1A).': [971], 'SRE': [973, 997, 1104, 1155, 1232], 'recognized': [975, 1463], 'factor,': [980, 1101, 3722, 4762], 'results': [983, 1321, 1373, 3068, 4143], 'recruitment': [985, 2144, 2556, 4121], '(TCF),': [991], 'cannot': [993], 'itself(10Treisman': [999], 'mitogenic': [1016], 'stimulation,': [1017], 'Elk-1,': [1018], 'one': [1019, 1413, 2029], 'candidate': [1022, 1211], 'TCFs(13Treisman': [1023], 'Curr.': [1025, 1217], 'Opin.': [1026, 1218], 'Genet.': [1027, 1219], '&': [1028, 1220, 1361, 1986, 2319, 3006, 3147, 3226, 3404, 3451, 3530, 3916, 3948], 'Dev.': [1029, 1221, 1362, 1987, 2320, 3007, 3148, 3227, 3405, 3452, 3531, 3917, 3949], '4:': [1031, 1223], '96-101Crossref': [1032, 1224], '(619)': [1035, 1227], 'phosphorylated,': [1040], 'most': [1041, 1407, 1516, 3605, 4625], 'likely': [1042, 1183, 1779], 'MAPKs(14Gille': [1050], 'Sharrocks': [1052, 1107, 3770], 'Shaw': [1054, 1109, 3772], '358:': [1058, 1113, 2579, 3776], '414-417Crossref': [1059, 1114, 3777], '(814)': [1062, 1117, 3780], '15Marais': [1065], 'Wynne': [1067, 1135], 'Treisman': [1069, 1137, 4725], '1993;': [1072, 1140, 1495, 1545, 1988, 2642, 3008, 3149, 3228, 3918, 4231, 4294], '73:': [1073, 1141], '381-393Abstract': [1074, 1142], '(1104)': [1080, 1148], 'Phosphorylation': [1083, 1676, 2137], 'Elk-1': [1085, 1177, 1196, 1297, 1668], 'reported': [1087], 'facilitate': [1089], 'formation': [1090], 'itself,': [1097], '(14Gille': [1105], 'Scholar)': [1119, 1618, 1637, 1905, 3925, 4706], 'transcription,': [1127, 1686], 'affecting': [1129, 2827], 'properties(15Marais': [1133], 'Since': [1151, 1230], 'vivo': [1153, 4316], 'appears': [1156], 'constitutively': [1159, 1508, 1535], 'occupied(10Treisman': [1160], 'increased': [1176, 1323, 1716], 'mechanism': [1184, 2418], 'activation': [1188, 1204, 1311, 2280, 2306, 2412, 2454, 2479, 2559, 3024, 3729, 3928, 4097, 4145, 4189, 4459, 4595], 'causes': [1189], 'induction.': [1191, 1319, 1691], 'phosphorylated': [1198, 1303, 1671, 1933, 2094, 2279, 2366, 2522, 3269, 3284], 'clustered': [1200], 'within': [1201, 1854, 2476], 'C-terminal': [1203, 2038, 2234, 2305], 'conserved': [1208, 2302], 'TCFs,': [1212], 'SAP-1(13Treisman': [1215], 'irradiation(16Buscher': [1244], 'Liftin': [1248], 'Oncogene.': [1254], '1988;': [1255, 1442, 3979], '3:': [1256, 1364, 2078, 2910], '301-311PubMed': [1257], 'only': [1262, 2002, 3049, 3242, 4467], 'marginal': [1264, 4469], 'activity(17Minden': [1268], 'Lin': [1270, 1977, 2044, 2876, 2997, 3138, 3217, 3635, 3745, 3799, 3907, 3992, 4072, 4337, 4485], 'Smeal': [1272, 1437, 1599, 1818, 1979, 2046, 2181, 2256, 2878, 2999, 3140, 3219, 3637, 3747, 3801, 3909, 3974], 'Dérijard': [1274, 2048, 2880, 3395, 3442, 3521, 3639, 3749, 3803, 3939], 'Cobb': [1276, 2050, 2882, 3641, 3751, 3805, 4024], 'Davis': [1278, 1579, 1627, 1961, 2052, 2503, 2531, 2602, 2884, 2936, 2984, 3399, 3446, 3525, 3643, 3753, 3807, 3891, 3943, 4000, 4080, 4345, 4396, 4493, 4550], '14:': [1286, 2060, 2892, 3651, 3761, 3815], '6683-6688Crossref': [1287, 2061, 2893, 3652, 3762, 3816], '(436)': [1290, 2064, 2896, 3655, 3765, 3819], 'possible': [1295], 'TCFs': [1300], 'MAPKs': [1306, 2825, 3072, 3590], '(see': [1307], 'below).': [1308, 1733], 'Nevertheless,': [1309], 'leads': [1312], 'elevated': [1314], 'via': [1317], 'This': [1320, 1422, 2344, 2688, 3540, 4142], 'synthesis': [1324, 1718, 1722], 'upon': [1328, 2548], 'translocation': [1329], 'nucleus': [1332, 4719], 'combines': [1333], 'pre-existing': [1335, 1751], 'dimers': [1341], 'than': [1346, 1467, 3386, 3423], 'formed': [1348], 'alone(18Smeal': [1352], 'Angel': [1354, 1487, 1822, 2634], 'Meek': [1356], 'Genes': [1360, 1985, 2318, 3005, 3146, 3225, 3403, 3450, 3529, 3915, 3947], '2091-2100Crossref': [1365], '(185)': [1368], 'Increased': [1371], 'stability': [1372], 'higher': [1375, 3493], 'levels': [1376], 'because': [1382, 3253, 3288], 'shifts': [1384], 'equilibrium': [1386], 'toward': [1387, 3419, 3428, 3497], 'dimer': [1388], 'formation,': [1389], 'essential': [1392, 3208], 'binding.': [1395], 'By': [1396], 'comparison': [1397], 'c-fos,': [1399, 1667], 'somewhat': [1404], 'simpler,': [1405], 'inducers': [1410], 'operate': [1411], 'through': [1412, 1759, 2143, 2555, 2693, 2830, 3262, 4102], 'major': [1414, 4109, 4764], 'element,': [1416], 'TRE': [1419, 1423, 1428, 1533, 1647], '1B).': [1421], 'differs': [1424], 'consensus': [1427], 'sequence': [1429, 2293], '1-base': [1431], 'pair': [1432], 'insertion(19Angel': [1433], 'Hattori': [1435, 3972], 'K.': [1436, 3973, 4227, 4290, 4366], '55:': [1443, 3980], '875-885Abstract': [1444, 3981], '(990)': [1450, 3987], 'due': [1454, 1714, 1743], 'subtle': [1457], 'change': [1458], 'efficiently': [1462, 2007, 3606], 'c-Jun·ATF2': [1465, 2467], 'conventional': [1469], 'complexes(20van': [1471], 'Dam': [1472, 2619, 2658], 'Duyndam': [1474, 2621], 'Rottier': [1476, 2623], 'Bosch': [1478, 2625], 'Vries-Smits': [1481, 2628], 'L.': [1482, 2629, 4169], 'Zantema': [1485, 2632], 'van': [1489, 2636, 2657, 2670], 'der': [1490, 2637, 2671], 'Eb': [1491, 2638, 2672], 'A.J.': [1492, 2315, 2639], 'EMBO': [1493, 2127, 2640], '479-487Crossref': [1497, 2644], '(342)': [1500, 2647], 'Unlike': [1503], 'c-Jun,': [1504, 1772, 1793, 2339, 2518, 3572], 'ATF2': [1505, 1620, 1680, 2470, 2519, 2544, 2564, 2928, 2960], 'expressed': [1509], 'protein.': [1510], 'However,': [1511, 2352, 4094], 'despite': [1512, 2353], 'inducible': [1514], 'expression,': [1515], 'types': [1518, 2790, 2823, 3588, 3961], 'contain': [1519], 'some': [1520, 4675], 'prior': [1523], 'Like': [1527, 2392, 2517], 'SRE,': [1530], 'occupied': [1536], 'vivo(21Rozek': [1538], 'Pfeifer': [1540], 'G.P.': [1541], '13:': [1546, 2130], '5490-5499Crossref': [1547], '(115)': [1550], 'exposure': [1554, 3715], 'JNK': [1562, 3365, 3728, 3790, 3870, 4101, 4458, 4594], 'MAPKs(22Dérijard': [1565], 'Hibi': [1567, 1949, 2123, 2491, 3879], 'Wu': [1569, 1951, 2493, 3881, 4390, 4544], 'I.-H.': [1570, 1952, 2494, 3882], 'Barrett': [1571, 1953, 2495, 3883, 4388, 4542], 'Su': [1573, 1955, 2497, 3389, 3436, 3515, 3885, 3933, 4828], 'Deng': [1575, 1957, 2499, 3317, 3887], '76:': [1583, 1965, 2507, 3895], '1-20Abstract': [1584, 1966, 2508, 3896], '(2953)': [1590, 1972, 2514, 3902], '(23Devary': [1595], 'Y.': [1596, 1604], 'Gottlieb': [1597], 'Bauskin': [1601], 'A.R.': [1602], 'Ben-Neriah': [1603], '71:': [1609], '1081-1091Abstract': [1610], '(795)': [1616], '(24Gupta': [1621, 2930], 'S.': [1622, 2068, 2526, 2568, 2597, 2656, 2900, 2931, 2979, 3162, 3168, 4031, 4049], 'Campbell': [1623, 2527, 2598, 2932, 2980], 'Derijard': [1625, 2529, 2600, 2934, 2982, 3998, 4078, 4343, 4491], '267:': [1631, 2535, 2606, 2940, 2988, 4400, 4554], '389-393Crossref': [1632, 2536, 2607, 2941, 2989], '(1336)': [1635, 2539, 2610, 2944, 2992], 'phosphorylated.': [1640], 'constitutive': [1642], 'occupancy': [1643], 'indicates': [1648], 'occurs': [1652], 'while': [1653, 1672], 'bound': [1657, 1673], 'promoter.': [1661], 'Similarly,': [1662], 'case': [1665, 1791], 'must': [1669], 'DNA.': [1675], 'stimulates': [1681, 2424], 'thereby': [1687, 2844], 'leading': [1688, 4111], 'Thus,': [1692, 4586], 'part': [1693, 1735, 3356, 3551], 'JNK-activating': [1703], '(such': [1705], 'necrosis': [1708, 3721], 'α,': [1710], 'irradiation)': [1712], 'possibly': [1720], '(as': [1723], 'JNKs': [1725, 1999, 3017, 3124, 3261, 3287, 3342, 3374, 4065, 4482], 'phosphorylate': [1728, 2008, 2028, 2841, 2851, 2953, 2964, 3084], 'Elk-1;': [1731], 'Another': [1734], 'phosphorylation.': [1746, 1761], 'newly': [1753, 1936], 'synthesized': [1754], 'modulated': [1758, 4634], 'So': [1762, 1996, 4252], 'far,': [1763, 1997, 3047, 4253], 'posttranslational': [1767], 'control': [1768], 'demonstrated': [1770, 2112], 'ATF2,': [1775], 'but': [1776, 1812, 2231, 2372, 2961, 3266, 3689], 'similarly': [1787], 'regulated.': [1788], 'In': [1789, 2917, 3178, 3323, 3578, 4432, 4739], 'cluster': [1797], 'located': [1800, 1853, 2034, 3129, 3509], 'next': [1801, 2035], 'basic': [1804], 'region': [1805, 3265, 3504], 'inhibits': [1806], 'homodimers': [1811], 'c-Jun·c-Fos': [1815, 2436], 'heterodimers(25Boyle': [1816], 'W.J.': [1817], 'Defize': [1820], 'L.H.K.': [1821], 'Woodgett': [1824, 1876, 3672, 3855, 4367], 'J.R.': [1825, 1877, 2201, 2767, 3673, 3823, 3856, 4368], 'Hunter': [1828], '64:': [1832], '573-584Abstract': [1833], '(852)': [1839], 'On': [1842], 'hand,': [1845, 2952, 4465], 'Ser-73': [1850, 2104, 2337, 3294], 'Ser-63,': [1852], 'domain,': [1857], 'potentiates': [1858, 2340], 'homodimer': [1867], '(26Pulverer': [1868], 'B.J.': [1869, 4364], 'Kyriakis': [1870], 'J.M.': [1871, 3659, 3842, 4372], 'Avruch': [1872, 3670, 3853], 'Nikolakaki': [1874, 3662, 3845], 'E.': [1875, 2752, 3663, 3846, 4019], '353:': [1880], '670-674Crossref': [1881], '(1191)': [1884], '27Smeal': [1887], 'D.A.': [1892], 'Birrer': [1893], '354:': [1899], '494-496Crossref': [1900], '(697)': [1903], 'heterodimer': [1908], 'c-Fos(9Deng': [1910, 2965], 'residues,': [1924, 3351], 'affect': [1928, 3052, 3364, 3592], 'activities,': [1931], 'discovered': [1937], 'family,': [1942], 'JNKs(22Dérijard': [1947], '28Hibi': [1975, 2995, 3905], 'Minden': [1981, 3001, 3142, 3221, 3911, 4409, 4509, 4563], '7:': [1989, 3009, 3150, 3229, 3919], '2135-2148Crossref': [1990, 3010, 3151, 3230, 3920], '(1708)': [1993, 3013, 3154, 3233, 3923], 'c-Jun.': [2013], 'Interestingly,': [2014, 2291], 'neither': [2015], 'ERK1': [2016], 'nor': [2017, 3708], 'ERK2': [2018], 'phosphorylates': [2019, 4152, 4331], 'stimulatory': [2022, 2955], 'instead': [2027, 2099], 'inhibitory': [2032], '(17Minden': [2042], '29Chou': [2067, 2899], 'Baichval': [2069, 2901], 'V.': [2070, 2902, 3158], 'Ferrell': [2071, 2903], '1117-1180Crossref': [2079, 2911], '(59)': [2082, 2914], 'Using': [2085], 'altered': [2087], 'specificity': [2088, 3109, 4157, 4328, 4449, 4776], 'mutant': [2089], 'JNK,': [2101], '(and': [2105], 'Ser-63': [2106, 3292], 'lesser': [2109], 'extent)': [2110], 'directly': [2115], 'responsible': [2116, 4185, 4590], 'potentiating': [2118], 'function(30Smeal': [2121], '6006-6010Crossref': [2131], '(84)': [2134], 'potentiate': [2139, 2243, 2858], '(CBP),': [2149], 'originally': [2154], 'virtue': [2157], 'phospho-CREB,': [2162], 'another': [2163], 'A(31Arias': [2173], 'Alberts': [2175, 2250], 'A.S.': [2176, 2251], 'Brindle': [2177, 2252], 'Claret': [2179, 2254, 4413, 4513, 4567], 'F.X.': [2180, 2255, 4414, 4514, 4568], 'Feramisco': [2185, 2260], 'Montminy': [2187, 2262], '370:': [2191, 2218, 2266], '226-229Crossref': [2192, 2267], '(680)': [2195, 2270], '32Kwok': [2198], 'R.P.': [2199], 'Lundblad': [2200], 'Chrivia': [2202], 'J.C.': [2203], 'Richards': [2204], 'J.P.': [2205], 'Bachinger': [2206], 'H.P.': [2207], 'Brennan': [2208], 'R.G.': [2209], 'Roberts': [2210, 4170], 'S.G.': [2211], 'Green': [2212, 2575], 'M.R.': [2213, 2576], 'Goodman': [2214, 2774, 3830], 'R.H.': [2215, 2775, 3831], '223-226Crossref': [2219], '(1280)': [2222], 'sites,': [2230, 2235, 2360], 'CBP': [2239, 2241, 2273, 2733], 'transcription(31Arias': [2248], 'postulated': [2275], 'connect': [2277], 'domains': [2281, 2455, 2560], 'basal': [2288], 'machinery.': [2290, 2460], 'surrounding': [2294], 'phosphoacceptors': [2297], '(33Sutherland': [2310], 'J.A.': [2311], 'Cook': [2312], 'Bannister': [2314], 'Kouzarides': [2316], '6:': [2322], '1810-1819Crossref': [2323], '(99)': [2326, 2685], 'suggesting': [2329, 2451, 3027], 'Thr-232,': [2333], 'homolog': [2335], 'prediction': [2345], 'had': [2346, 4673], 'turned': [2347], 'out': [2348], 'correct.': [2351], 'similarity': [2355], 'between': [2356, 3130, 4257], 'two': [2358, 3372], 'phosphoacceptor': [2359, 3348], 'Thr-232': [2361, 2423], 'JNK1': [2369, 3427, 3479], 'JNK2': [2371, 3379, 3418, 3465, 3496, 3564], 'novel': [2375], '88-kDa': [2376], 'termed': [2378], 'FRK(9Deng': [2379], 'ERKs': [2394, 2840, 2920, 3603], 'JNKs,': [2397, 2796, 2948, 3188, 3252], 'FRK': [2398, 3684, 3707], 'proline-directed': [2401], 'kinase,': [2402], 'stimulated': [2407, 3607, 3713, 3794, 3965], 'Ha-Ras': [2411], 'factors.': [2415, 4785], 'Although': [2416, 2613, 3958, 4275], 'clear,': [2430], 'context': [2433], 'heterodimer,': [2437], 'each': [2440, 2820], 'makes': [2442], 'contribution': [2445], 'stimulation': [2447, 3212], 'interact': [2456], 'situation': [2463], 'apply': [2465], 'heterodimers,': [2468], 'Thr-63': [2473], 'Thr-71': [2475], 'shown': [2483, 2729], '(22Dérijard': [2489, 3877], 'JNKs(24Gupta': [2525], 'Transactivation': [2542], 'potentiated': [2547], 'Rb': [2551, 2589], 'E1A,': [2553], 'probably': [2554], 'additional': [2558], 'DNA-bound': [2563], 'dimer(34Kim': [2565], 'S.J.': [2566, 4128], 'Wagner': [2567], 'Liu': [2569], 'F.': [2570, 2707, 4418, 4518, 4572], "O'Reilly": [2571], 'Robbins': [2573], 'P.D.': [2574], '331-334Crossref': [2580], '(212)': [2583], 'Both': [2586], 'E1A': [2587, 2614, 2704, 2739], 'act': [2590], 'concert': [2592], 'ATF2(24Gupta': [2596], 'induce': [2616, 2845], 'transcription(20van': [2618], 'represses': [2651], 'activity(35Offringa': [2653], 'Gebel': [2655], 'Timmers': [2660], 'Smits': [2662], 'Zwart': [2664], 'Bos': [2668], 'J.L.': [2669], '1990;': [2677], '62:': [2678], '527-538Abstract': [2679], 'repression': [2689], 'could': [2690], 'mediated': [2692], 'competition': [2694], 'CBP,': [2696], 'very': [2699, 4600], 'p300': [2703, 2731], 'protein(36Arany': [2706], 'Sellers': [2708], 'W.R.': [2709], 'Livingstone': [2710], 'D.M.': [2711, 2754], 'Eickner': [2712], '97:': [2716], '799-800Abstract': [2717], '(370)': [2722], 'Indeed,': [2725], 'functionally': [2735], 'interchangeable': [2736], 'inhibit': [2741], 'coactivation': [2743], 'function': [2744], 'factors(37Arany': [2747], 'Z.': [2748], 'Newsome': [2749], 'Oldread': [2751], 'Livingston': [2753], 'Eckner': [2755], '374:': [2759, 2778, 3834], '81-84Crossref': [2760], '(490)': [2763], '38Lundblad': [2766, 3822], 'Kwok': [2768, 3824], 'R.P.S.': [2769, 3825], 'Laurance': [2770, 3826], 'Harter': [2772, 3828], 'M.L.': [2773, 3829], '85-88Crossref': [2779, 3835], '(531)': [2782, 3838], 'As': [2785], 'described': [2786], 'above,': [2787], 'three': [2788, 3587, 3960], 'different': [2789, 2834, 3473, 4103, 4637, 4757], 'MAPKs,': [2792, 3547], 'ERKs,': [2794, 3789], 'FRKs,': [2798], 'contribute': [2799, 4445, 4617], 'array': [2810], 'stimuli.': [2813, 3601, 4665], 'It': [2814, 4786], 'considerable': [2817], 'interest': [2818, 4439], 'substrate': [2835, 3108, 3584], '2).': [2837], 'While': [2838, 4605], 'TCF/Elk-1': [2842], 'they': [2848, 3028], 'activities(9Deng': [2861], '17Minden': [2874, 3633, 3743], 'addition,': [2918], 'appear': [2923], '24Gupta': [2978], 'capable': [3020], 'TCF/Elk-1,': [3026], 'under': [3035], 'certain': [3036], 'circumstances.2': [3037], '2M.': [3038], 'Cavigelli': [3039], 'Karin,': [3042, 3278, 3320], 'unpublished': [3043, 3279, 3321], 'results.': [3044, 3280, 3322], 'FRK,': [3045], 'so': [3046, 4652], 'known': [3050], 'activity(9Deng': [3054], 'clearly': [3069], 'indicate': [3070], 'highly': [3074, 4809], 'choice': [3078], 'substrates': [3080, 3469], 'just': [3085], 'Ser': [3087], 'Thr': [3089], 'residue': [3090], 'followed': [3093, 3299], 'Pro,': [3096], 'previously': [3098], 'assumed.': [3099], 'molecular': [3101], 'underlying': [3103], 'high': [3105], 'degree': [3106], 'being': [3111], 'explored': [3112], 'Jun-JNK': [3115], 'interaction': [3116, 4256], 'paradigm.': [3119], 'Efficient': [3120], 'requires': [3125, 3343], 'docking': [3127, 3205, 3237, 3327, 3359, 3569], 'site': [3128, 3181, 3206, 3238, 3328, 3360], 'residues': [3131, 3345, 3508], '30': [3132], '60': [3134], 'c-Jun(28Hibi': [3136], '39Adler': [3157], 'Franklin': [3159], 'C.C.': [3160], 'Kraft': [3161], 'Proc.': [3163, 4026], 'Natl.': [3164, 4027], 'Acad.': [3165, 4028], 'U.': [3167, 4030], '89:': [3171, 4034], '5341-5345Crossref': [3172], '(138)': [3175], 'vitro,': [3179], 'c-Jun·JNK': [3191], 'been': [3196, 4262, 4650], 'detected': [3197], 'living': [3199], 'cells,': [3200], 'integrity': [3202], 'activity(28Hibi': [3215], 'feature': [3243], 'ensures': [3247], 'efficient': [3248, 3335, 4281], 'vitro': [3255, 4277], 'JunB': [3256, 3281], 'binds': [3258], 'them.3': [3271], '3T.': [3272], 'Deng,': [3273], 'Kallunki,': [3275], 'homologs': [3290], 'prolines.': [3301], 'Once': [3302], 'prolines': [3303], 'inserted': [3305], 'after': [3306, 3874], 'serines': [3308], 'JunB,': [3310], 'resulting': [3312], 'variant': [3313], 'becomes': [3314], 'JNK-responsive.4': [3315], '4T.': [3316], 'addition': [3324, 3579, 4740], 'Pro': [3330], 'P+1': [3333], 'position,': [3334], 'flanking': [3346], 'site.': [3349], 'binding.3': [3366], 'When': [3367], 'compared,': [3378], 'much': [3384], 'better': [3385], 'JNK1(40Kallunki': [3387], 'Tsigelny': [3391, 3438, 3517, 3935], 'I.': [3392, 3439, 3518, 3936, 4360], 'Sluss': [3393, 3440, 3519, 3937], 'H.K.': [3394, 3441, 3520, 3938], 'Moore': [3397, 3444, 3523, 3941], '8:': [3407, 3454, 3533, 3951], '2996-3007Crossref': [3408, 3455, 3534, 3952], '(593)': [3411, 3458, 3537, 3955], 'Consequently,': [3414], 'Km': [3416, 3425], 'lower': [3422], 'Vm': [3432], 'higher(40Kallunki': [3434], 'catalytic': [3462, 3512, 3554], 'properties': [3463], 'JNK1,': [3477], 'effective': [3484, 3726], 'substrates.': [3488], 'basis': [3490], 'affinity': [3494], 'traced': [3500], 'small': [3503], 'approximately': [3506], '20': [3507], 'near': [3510], 'pocket(40Kallunki': [3513], 'region,': [3541], 'variable': [3544], 'among': [3545], 'pocket': [3555], 'itself.': [3556], 'likely,': [3558], 'interacts': [3566], 'illustrated': [3574], 'Fig.': [3576], '3.': [3577], 'differences': [3582], 'responses': [3598], 'factors': [3610, 3688, 4443], 'esters(6Cobb': [3613], '41Kyriakis': [3658, 3841], 'Banerjee': [3660, 3843], 'Dai': [3664, 3847], 'Rubie': [3666, 3849], 'E.A.': [3667, 3850], 'Ahmad': [3668, 3851], 'M.F.': [3669, 3852], '369:': [3676, 3859, 4135], '156-160Crossref': [3677, 3860], '(2411)': [3680, 3863], 'whereas': [3683], 'responds': [3685], 'esters(9Deng': [3693], 'Neither': [3706], '(9Deng': [3730], '14Gille': [3768], 'Compared': [3783], 'FRKs': [3786], 'modestly': [3793], 'factors(17Minden': [3797], 'largest': [3867], 'increases': [3868], 'observed': [3873], 'costimulatory': [3927], 'cells(40Kallunki': [3931], 'Ras': [3969, 4096, 4113, 4207, 4258], 'activation(19Angel': [3970], '42Minden': [3990], 'McMahon': [3994, 4074, 4339, 4487], 'Lange-Carter': [3996, 4076, 4341, 4415, 4489, 4515, 4569], 'Johnson': [4002, 4082, 4228, 4241, 4291, 4304, 4347, 4419, 4495, 4519, 4573], 'G.L.': [4003, 4083, 4242, 4305, 4348, 4420, 4496, 4520, 4574], '226:': [4008, 4088, 4353, 4501], '1719-1723Crossref': [4009, 4089, 4354, 4502], '(1011)': [4011, 4091, 4356, 4504], '43Robbins': [4014], 'D.J.': [4015], 'Cheng': [4016], 'Zhen': [4018], 'Vanderbilt': [4020], 'C.A.': [4021, 4221, 4240, 4284, 4303], 'Feig': [4022], 'L.A.': [4023], 'M.H.': [4025], '6924-6928Crossref': [4035], '(148)': [4038], '44Thomas': [4041], 'S.M.': [4042], 'De': [4043], 'Marco': [4044], "D'Arcangelo": [4046], 'Halegoua': [4048], 'Brugge': [4050], 'J.S.': [4051], '68:': [4054], '1031-1040Abstract': [4055], '(503)': [4061], 'respond': [4067], 'Ras-independent': [4069], 'signals(42Minden': [4070], 'even': [4095, 4790], 'affects': [4098], 'cascades': [4105, 4589, 4804], '4).': [4107, 4604], 'pathway': [4110], 'based': [4117], 'Ras-mediated': [4120], 'Raf-1': [4123], 'plasma': [4126], 'membrane(45Leevers': [4127], 'Paterson': [4129], 'H.F.': [4130], 'Marshall': [4131], '411-414Crossref': [4136], '(881)': [4139], 'Raf-1,': [4147, 4461], 'Ser/Thr': [4149, 4212], 'activates': [4154, 4209, 4319, 4333], 'dual': [4156, 4327], 'MEK1': [4159], 'MEK2': [4161], '(46Dent': [4162], 'Hasar': [4164], 'Haystead': [4166], 'Vincent': [4168], 'Sturgill': [4172], '254:': [4176], '1404-1407Crossref': [4177], '(498)': [4179], 'latter': [4183], 'ERKs(47Crews': [4192], 'C.G.': [4193], 'Alessandrini': [4194], 'Erickson': [4196], 'R.L.': [4197], '258:': [4200], '478-480Crossref': [4201], '(738)': [4204], 'MEKK1,': [4210], 'unrelated': [4214], 'primary': [4217], 'structure': [4218], 'Raf(48Lange-Carter': [4220], 'Pleiman': [4222, 4285], 'Gardner': [4224, 4287], 'Blumer': [4226, 4289], '260:': [4232, 4295], '315-319Crossref': [4233, 4296], '(873)': [4236, 4299], '49Lange-Carter': [4239, 4302], '265:': [4245, 4308], '1458-1461Crossref': [4246, 4309], '(295)': [4249, 4312], 'no': [4254], 'direct': [4255], 'MEKK1': [4260, 4278, 4451], 'observed,': [4263], 'clear': [4268, 4788], 'how': [4269], 'Ras.': [4274], 'MEK': [4282], 'activator(48Lange-Carter': [4283], 'mostly': [4318], 'JNKK1': [4320, 4472, 4533], '(also': [4321], 'called': [4322], 'SEK1': [4323], 'MKK4),': [4325], 'JNKs(42Minden': [4335], '50Sanchez': [4359], 'Hughes': [4361], 'R.T.': [4362], 'Mayer': [4363], 'Yee': [4365], 'Arrach': [4369], 'Kyrriakes': [4371], 'Zon': [4373], 'L.I.': [4374], '372:': [4377], '794-798Crossref': [4378], '(916)': [4381], '51Dérijard': [4384], 'Raingeaud': [4386, 4540], 'I.H.': [4391, 4545], 'Han': [4392, 4546], 'Ulevitch': [4394, 4548], '682-685Crossref': [4401, 4555], '(1407)': [4404, 4558], '52Lin': [4407, 4507, 4561], 'Martinetto': [4411, 4511, 4565], 'Mercurio': [4417, 4517, 4571], '268:': [4425, 4525, 4579], '286-290Crossref': [4426, 4526, 4580], '(708)': [4429, 4529, 4583], 'future': [4434, 4768], 'would': [4436], 'identify': [4441], 'limiting': [4447], 'action': [4452], 'confine': [4454], 'cascade.': [4460], 'none': [4475], 'MEKs': [4478], '(42Minden': [4483], 'Likewise,': [4532], 'does': [4534], 'ERKs(51Dérijard': [4538], 'distinct': [4597], 'exhibit': [4599], 'little': [4601], 'cross-talk': [4602], 'great': [4607], 'deal': [4608], 'remains': [4609], 'learned': [4612], 'about': [4613], 'expression': [4632], 'forms': [4638, 4758], 'identified,': [4645], 'quite': [4646], 'lot': [4648], 'revealed': [4651, 4674], 'far': [4653], 'focusing': [4655], 'importantly,': [4667], 'investigation': [4669], 'general': [4678], 'modulates': [4684], '53Hunter': [4691], '70:': [4697], '375-387Abstract': [4698], '(1118)': [4704], 'strategies': [4709], 'surface': [4713], 'receptors': [4714], 'communicate': [4716], '54Hill': [4723], 'C.S.': [4724], '199-211Abstract': [4730], '(1195)': [4736], 'identification': [4743], 'will': [4750], 'explain': [4751], 'physiological': [4753], 'challenge': [4765], 'understanding': [4770], 'confer': [4774], 'biological': [4775, 4811], 'actions': [4779], 'generic': [4791], 'ubiquitous': [4793], 'signaling': [4794], 'like': [4796], 'responses.': [4812], 'I': [4813], 'thank': [4814], 'Alford': [4816], 'preparation': [4818, 4830], 'manuscript': [4821], 'Drs.': [4823], 'Kallunki': [4825], 'figures.': [4833]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2118897660', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 21}, {'year': 2022, 'cited_by_count': 44}, {'year': 2021, 'cited_by_count': 45}, {'year': 2020, 'cited_by_count': 48}, {'year': 2019, 'cited_by_count': 41}, {'year': 2018, 'cited_by_count': 53}, {'year': 2017, 'cited_by_count': 50}, {'year': 2016, 'cited_by_count': 53}, {'year': 2015, 'cited_by_count': 54}, {'year': 2014, 'cited_by_count': 60}, {'year': 2013, 'cited_by_count': 55}, {'year': 2012, 'cited_by_count': 47}], 'updated_date': '2024-12-25T03:40:31.817635', 'created_date': '2016-06-24'}