Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2118548006', 'doi': 'https://doi.org/10.1212/wnl.47.2.449', 'title': 'Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein', 'display_name': 'Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein', 'publication_year': 1996, 'publication_date': '1996-08-01', 'ids': {'openalex': 'https://openalex.org/W2118548006', 'doi': 'https://doi.org/10.1212/wnl.47.2.449', 'mag': '2118548006', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8757019'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1212/wnl.47.2.449', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091608192', 'display_name': 'Jörg Tatzelt', 'orcid': 'https://orcid.org/0000-0001-5017-5528'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. Tatzelt', 'raw_affiliation_strings': ['Department of Neurology, University of California, San Francisco 94143-0518, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, University of California, San Francisco 94143-0518, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055092354', 'display_name': 'Nobuyo Maeda', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'N. Maeda', 'raw_affiliation_strings': ['Pathology and Laboratory Medicine'], 'affiliations': [{'raw_affiliation_string': 'Pathology and Laboratory Medicine', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078058223', 'display_name': 'Milos Pekny', 'orcid': 'https://orcid.org/0000-0003-1607-8075'}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'M. Pekny', 'raw_affiliation_strings': [' University of Gothenburg'], 'affiliations': [{'raw_affiliation_string': ' University of Gothenburg', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110102432', 'display_name': 'Shu Lian Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S.-L. Yang', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051005847', 'display_name': 'Christer Betsholtz', 'orcid': 'https://orcid.org/0000-0002-8494-971X'}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'C. Betsholtz', 'raw_affiliation_strings': [' University of Gothenburg'], 'affiliations': [{'raw_affiliation_string': ' University of Gothenburg', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076436285', 'display_name': 'Camilla Eliasson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'C. Eliasson', 'raw_affiliation_strings': [' University of Gothenburg'], 'affiliations': [{'raw_affiliation_string': ' University of Gothenburg', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010315238', 'display_name': 'Juliana Cayetano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. Cayetano', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000785421', 'display_name': 'Almerian P Camerino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A. P. Camerino', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111954411', 'display_name': 'S. J. DeArmond', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. J. DeArmond', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066991343', 'display_name': 'Stanley B. Prusiner', 'orcid': 'https://orcid.org/0000-0003-1955-5498'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S. B. Prusiner', 'raw_affiliation_strings': ['University of California at San Francisco,'], 'affiliations': [{'raw_affiliation_string': 'University of California at San Francisco,', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.159, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.843198, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '47', 'issue': '2', 'first_page': '449', 'last_page': '453'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13481', 'display_name': 'Neurological diseases and metabolism', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gliosis', 'display_name': 'Gliosis', 'score': 0.9270584}, {'id': 'https://openalex.org/keywords/apolipoprotein-e', 'display_name': 'Apolipoprotein E', 'score': 0.65329516}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.51387763}, {'id': 'https://openalex.org/keywords/neuroglia', 'display_name': 'Neuroglia', 'score': 0.4619397}, {'id': 'https://openalex.org/keywords/slow-virus', 'display_name': 'Slow virus', 'score': 0.43484095}], 'concepts': [{'id': 'https://openalex.org/C2777682930', 'wikidata': 'https://www.wikidata.org/wiki/Q1531490', 'display_name': 'Gliosis', 'level': 2, 'score': 0.9270584}, {'id': 'https://openalex.org/C2780495277', 'wikidata': 'https://www.wikidata.org/wiki/Q905442', 'display_name': 'Glial fibrillary acidic protein', 'level': 3, 'score': 0.91356146}, {'id': 'https://openalex.org/C2776735649', 'wikidata': 'https://www.wikidata.org/wiki/Q170102', 'display_name': 'Scrapie', 'level': 4, 'score': 0.87293065}, {'id': 'https://openalex.org/C57089818', 'wikidata': 'https://www.wikidata.org/wiki/Q424728', 'display_name': 'Apolipoprotein E', 'level': 3, 'score': 0.65329516}, {'id': 'https://openalex.org/C2777542381', 'wikidata': 'https://www.wikidata.org/wiki/Q502961', 'display_name': 'Astrocyte', 'level': 3, 'score': 0.63497007}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.51387763}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48226506}, {'id': 'https://openalex.org/C2780884517', 'wikidata': 'https://www.wikidata.org/wiki/Q177105', 'display_name': 'Neuroglia', 'level': 3, 'score': 0.4619397}, {'id': 'https://openalex.org/C148632171', 'wikidata': 'https://www.wikidata.org/wiki/Q7542129', 'display_name': 'Slow virus', 'level': 4, 'score': 0.43484095}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.34736848}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24358341}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.21444327}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.18386367}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.14588574}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12355664}, {'id': 'https://openalex.org/C3019804061', 'wikidata': 'https://www.wikidata.org/wiki/Q14881255', 'display_name': 'Prion protein', 'level': 3, 'score': 0.12112588}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.11076045}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.109941155}, {'id': 'https://openalex.org/C2780640218', 'wikidata': 'https://www.wikidata.org/wiki/Q8277', 'display_name': 'Multiple sclerosis', 'level': 2, 'score': 0.088306546}, {'id': 'https://openalex.org/C2780644213', 'wikidata': 'https://www.wikidata.org/wiki/Q704930', 'display_name': 'Progressive multifocal leukoencephalopathy', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D005904', 'descriptor_name': 'Glial Fibrillary Acidic Protein', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D012608', 'descriptor_name': 'Scrapie', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005904', 'descriptor_name': 'Glial Fibrillary Acidic Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012608', 'descriptor_name': 'Scrapie', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1212/wnl.47.2.449', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8757019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.48, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1536955134', 'https://openalex.org/W1543396712', 'https://openalex.org/W1617626072', 'https://openalex.org/W194253135', 'https://openalex.org/W1996218943', 'https://openalex.org/W1997441257', 'https://openalex.org/W2005141599', 'https://openalex.org/W2014178085', 'https://openalex.org/W2021561354', 'https://openalex.org/W2027957445', 'https://openalex.org/W2028206171', 'https://openalex.org/W2040753345', 'https://openalex.org/W2053547329', 'https://openalex.org/W2056526354', 'https://openalex.org/W2070692986', 'https://openalex.org/W2076583884', 'https://openalex.org/W2085127080', 'https://openalex.org/W2085407614', 'https://openalex.org/W2089958271', 'https://openalex.org/W2142209458', 'https://openalex.org/W2164216215', 'https://openalex.org/W2325211721', 'https://openalex.org/W2409802673', 'https://openalex.org/W2411110185', 'https://openalex.org/W2969886792', 'https://openalex.org/W4231687994', 'https://openalex.org/W4234400242', 'https://openalex.org/W4237792806', 'https://openalex.org/W4240585096', 'https://openalex.org/W49982654'], 'related_works': ['https://openalex.org/W2400648149', 'https://openalex.org/W2372521946', 'https://openalex.org/W2118548006', 'https://openalex.org/W2095989144', 'https://openalex.org/W2086329643', 'https://openalex.org/W2083045022', 'https://openalex.org/W2075370332', 'https://openalex.org/W1985134652', 'https://openalex.org/W1976767726', 'https://openalex.org/W1968884955'], 'abstract_inverted_index': {'In': [0], 'the': [1, 16, 23, 32, 43, 65, 99, 124, 127, 131], 'prion': [2], 'diseases,': [3], 'extensive': [4], 'reactive': [5, 66], 'gliosis': [6, 27, 67], 'is': [7], 'often': [8], 'found': [9], 'to': [10, 15, 111], 'be': [11], 'out': [12], 'of': [13, 18, 25, 31, 54, 64, 92, 101, 126, 133], 'proportion': [14], 'degree': [17], 'apparent': [19], 'neuronal': [20], 'damage.To': [21], 'evaluate': [22], 'role': [24], 'astrocytic': [26], 'in': [28, 38, 59, 74, 98, 105, 123, 130], 'experimental': [29], 'scrapie': [30], 'mouse,': [33], 'we': [34], 'inoculated': [35, 79], 'mice': [36, 72, 103], 'deficient': [37, 73, 104], 'apolipoprotein': [39], 'E': [40], '(apoE)': [41], 'or': [42, 77, 129], 'glial': [44], 'fibrillary': [45], 'acidic': [46], 'protein': [47, 107], '(GFAP)': [48], 'with': [49, 80], 'mouse': [50], 'prions.': [51], 'The': [52, 90], 'expression': [53], 'both': [55], 'apoE': [56, 76, 119], 'and': [57, 94], 'GFAP': [58, 78, 121], 'astrocytes': [60], 'increases': [61], 'as': [62], 'part': [63], 'that': [68, 117], 'accompanies': [69], 'scrapie.': [70], 'Null': [71], 'either': [75, 106], 'prions': [81], 'exhibited': [82], 'incubation': [83], 'times': [84], 'indistinguishable': [85], 'from': [86], 'untargeted': [87], 'control': [88, 112], 'mice.': [89, 113], 'level': [91], 'PrP<sup>Sc</sup>': [93], 'its': [95], 'regional': [96], 'deposition': [97], 'brains': [100], 'ill': [102], 'were': [108], 'also': [109], 'similar': [110], 'Our': [114], 'findings': [115], 'demonstrate': [116], 'neither': [118], 'nor': [120], 'participates': [122], 'pathogenesis': [125], 'disease': [128], 'production': [132], 'PrP<sup>Sc</sup>.': [134], '<b>NEUROLOGY': [135], '1996;47:': [136], '</b>': [137], '449-453': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2118548006', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-11T11:14:15.836063', 'created_date': '2016-06-24'}