Publication Information

{'id': 'https://openalex.org/W2118330889', 'doi': 'https://doi.org/10.1074/jbc.m211161200', 'title': 'Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein', 'display_name': 'Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein', 'publication_year': 2003, 'publication_date': '2003-06-29', 'ids': {'openalex': 'https://openalex.org/W2118330889', 'doi': 'https://doi.org/10.1074/jbc.m211161200', 'mag': '2118330889', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12707272'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m211161200', 'pdf_url': 'http://www.jbc.org/article/S002192582086880X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S002192582086880X/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030640907', 'display_name': 'Toru Sato', 'orcid': 'https://orcid.org/0000-0002-7866-8671'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}, {'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toru Sato', 'raw_affiliation_strings': ['Department of Life Science, Graduate School of Arts and Science, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan, the', 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}, {'raw_affiliation_string': 'Department of Life Science, Graduate School of Arts and Science, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan, the', 'institution_ids': ['https://openalex.org/I161296585', 'https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019809723', 'display_name': 'Naoshi Dohmae', 'orcid': 'https://orcid.org/0000-0002-5242-9410'}, 'institutions': [{'id': 'https://openalex.org/I4210110652', 'display_name': 'RIKEN', 'ror': 'https://ror.org/01sjwvz98', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoshi Dohmae', 'raw_affiliation_strings': ['Biomolecular Characterization Division, Characterization Center, The Institute of Physical and Chemical Research, Wako, Saitama 351-0198, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Biomolecular Characterization Division, Characterization Center, The Institute of Physical and Chemical Research, Wako, Saitama 351-0198, Japan, the', 'institution_ids': ['https://openalex.org/I4210110652']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039117237', 'display_name': 'Yue Qi', 'orcid': 'https://orcid.org/0000-0003-1914-8710'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yue Qi', 'raw_affiliation_strings': ['Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070254459', 'display_name': 'Nobuto Kakuda', 'orcid': 'https://orcid.org/0000-0001-7011-6891'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobuto Kakuda', 'raw_affiliation_strings': ['Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064635839', 'display_name': 'Hiroaki Misonou', 'orcid': 'https://orcid.org/0000-0001-5892-1804'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Misonou', 'raw_affiliation_strings': ['Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064182538', 'display_name': 'Rie Mitsumori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Rie Mitsumori', 'raw_affiliation_strings': ['Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030974055', 'display_name': 'Hiroko Maruyama', 'orcid': 'https://orcid.org/0000-0002-5619-0099'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hiroko Maruyama', 'raw_affiliation_strings': ['Department of Neurosciences, University of California, San Diego, La Jolla, California 92093'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosciences, University of California, San Diego, La Jolla, California 92093', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084447225', 'display_name': 'Edward H. Koo', 'orcid': 'https://orcid.org/0000-0003-1337-8806'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward H. Koo', 'raw_affiliation_strings': ['Department of Neurosciences, University of California, San Diego, La Jolla, California 92093'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosciences, University of California, San Diego, La Jolla, California 92093', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065084452', 'display_name': 'Christian Haass', 'orcid': 'https://orcid.org/0000-0002-4869-1627'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christian Haass', 'raw_affiliation_strings': ["Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, D-80336 Munich, Germany"], 'affiliations': [{'raw_affiliation_string': "Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, D-80336 Munich, Germany", 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109803841', 'display_name': 'Koji Takio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110652', 'display_name': 'RIKEN', 'ror': 'https://ror.org/01sjwvz98', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koji Takio', 'raw_affiliation_strings': ['Biomolecular Characterization Division, Characterization Center, The Institute of Physical and Chemical Research, Wako, Saitama 351-0198, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Biomolecular Characterization Division, Characterization Center, The Institute of Physical and Chemical Research, Wako, Saitama 351-0198, Japan, the', 'institution_ids': ['https://openalex.org/I4210110652']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005480143', 'display_name': 'Maho Morishima‐Kawashima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Maho Morishima-Kawashima', 'raw_affiliation_strings': ['Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003315468', 'display_name': 'Shoichi Ishiura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}, {'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shoichi Ishiura', 'raw_affiliation_strings': ['Department of Life Science, Graduate School of Arts and Science, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Science, Graduate School of Arts and Science, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan, the', 'institution_ids': ['https://openalex.org/I161296585', 'https://openalex.org/I74801974']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016024085', 'display_name': 'Yasuo Ihara', 'orcid': 'https://orcid.org/0000-0003-3072-2410'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yasuo Ihara', 'raw_affiliation_strings': ['Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, the', 'institution_ids': ['https://openalex.org/I74801974']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5016024085'], 'corresponding_institution_ids': ['https://openalex.org/I74801974'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.861, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 141, 'citation_normalized_percentile': {'value': 0.94736, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '278', 'issue': '27', 'first_page': '24294', 'last_page': '24301'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11419', 'display_name': 'Supramolecular Self-Assembly in Materials', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fragment', 'display_name': 'Fragment (logic)', 'score': 0.78325367}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.61267275}], 'concepts': [{'id': 'https://openalex.org/C2776235265', 'wikidata': 'https://www.wikidata.org/wiki/Q18392052', 'display_name': 'Fragment (logic)', 'level': 2, 'score': 0.78325367}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.61267275}, {'id': 'https://openalex.org/C31705614', 'wikidata': 'https://www.wikidata.org/wiki/Q423510', 'display_name': 'Amyloid precursor protein', 'level': 4, 'score': 0.5759863}, {'id': 'https://openalex.org/C2779664074', 'wikidata': 'https://www.wikidata.org/wiki/Q3518405', 'display_name': 'Terminal (telecommunication)', 'level': 2, 'score': 0.5560867}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4792871}, {'id': 'https://openalex.org/C3019447875', 'wikidata': 'https://www.wikidata.org/wiki/Q417667', 'display_name': 'Amyloid β', 'level': 3, 'score': 0.43530527}, {'id': 'https://openalex.org/C180081513', 'wikidata': 'https://www.wikidata.org/wiki/Q4914721', 'display_name': "Biochemistry of Alzheimer's disease", 'level': 5, 'score': 0.42184162}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40243158}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21090737}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1802946}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.12189689}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.117957234}, {'id': 'https://openalex.org/C11413529', 'wikidata': 'https://www.wikidata.org/wiki/Q8366', 'display_name': 'Algorithm', 'level': 1, 'score': 0.0821819}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.05895132}, {'id': 'https://openalex.org/C179104552', 'wikidata': 'https://www.wikidata.org/wiki/Q11165', 'display_name': 'Inorganic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C76155785', 'wikidata': 'https://www.wikidata.org/wiki/Q418', 'display_name': 'Telecommunications', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002474', 'descriptor_name': 'Cell-Free System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m211161200', 'pdf_url': 'http://www.jbc.org/article/S002192582086880X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12707272', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m211161200', 'pdf_url': 'http://www.jbc.org/article/S002192582086880X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.54, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1522789528', 'https://openalex.org/W1534001036', 'https://openalex.org/W1541961513', 'https://openalex.org/W1626267121', 'https://openalex.org/W1660631781', 'https://openalex.org/W1967027232', 'https://openalex.org/W1974864309', 'https://openalex.org/W1979543098', 'https://openalex.org/W1990962430', 'https://openalex.org/W1991435932', 'https://openalex.org/W2000582255', 'https://openalex.org/W2012968591', 'https://openalex.org/W2019010572', 'https://openalex.org/W2019486380', 'https://openalex.org/W2030082602', 'https://openalex.org/W2032232498', 'https://openalex.org/W2032665239', 'https://openalex.org/W2037318207', 'https://openalex.org/W2055010339', 'https://openalex.org/W2056790763', 'https://openalex.org/W2057709960', 'https://openalex.org/W2063886117', 'https://openalex.org/W2076444547', 'https://openalex.org/W2082022687', 'https://openalex.org/W2086324585', 'https://openalex.org/W2088881960', 'https://openalex.org/W2130144581', 'https://openalex.org/W2133019124', 'https://openalex.org/W2134365974', 'https://openalex.org/W2138447190', 'https://openalex.org/W2164742714', 'https://openalex.org/W2167182434', 'https://openalex.org/W2168087300', 'https://openalex.org/W2169152986', 'https://openalex.org/W2412568181'], 'related_works': ['https://openalex.org/W2465438320', 'https://openalex.org/W2394822779', 'https://openalex.org/W2365040744', 'https://openalex.org/W2257897195', 'https://openalex.org/W2148059849', 'https://openalex.org/W2018753627', 'https://openalex.org/W2003796440', 'https://openalex.org/W1998177934', 'https://openalex.org/W1972034064', 'https://openalex.org/W1585690852'], 'abstract_inverted_index': {'A': [0, 171, 468, 2207, 2224, 2286, 2396, 2673, 2841, 3565, 3653, 4065], 'novel': [1, 172], 'cleavage': [2, 36, 173, 207, 498, 1074, 1093, 3669, 3809, 4099, 4658], 'of': [3, 14, 83, 107, 128, 135, 150, 163, 174, 185, 254, 278, 299, 306, 321, 334, 345, 349, 438, 455, 577, 588, 600, 615, 628, 806, 905, 913, 918, 959, 1060, 1067, 1094, 1109, 1118, 1322, 1354, 1358, 1381, 1388, 1405, 1651, 1684, 1762, 1782, 1811, 1819, 1885, 1997, 2036, 2063, 2099, 2140, 2157, 2161, 2174, 2197, 2203, 2215, 2243, 2252, 2375, 2384, 2399, 2412, 2426, 2454, 2460, 2467, 2537, 2544, 2550, 2557, 2562, 2613, 2632, 2666, 2685, 2690, 2805, 2820, 2857, 2876, 2894, 2932, 2941, 3054, 3084, 3142, 3164, 3186, 3222, 3236, 3265, 3277, 3286, 3291, 3302, 3321, 3330, 3340, 3345, 3354, 3366, 3378, 3389, 3399, 3433, 3470, 3481, 3515, 3546, 3574, 3593, 3644, 3726, 3797, 3805, 3811, 3865, 3876, 3885, 3905, 3914, 3931, 3945, 3952, 3958, 3968, 3975, 3984, 4001, 4045, 4054, 4067, 4090, 4257, 4337, 4348, 4350, 4365, 4374, 4380, 4393, 4427, 4461, 4478, 4496, 4630, 4711, 4781, 4824, 4847, 4853], 'β-amyloid': [4, 175, 364, 405, 492], 'precursor': [5, 176, 365, 406, 493], 'protein': [6, 177, 494, 1649, 1984], '(APP),': [7, 178, 495], 'referred': [8, 179, 501], 'to': [9, 29, 131, 138, 180, 200, 302, 309, 502, 633, 862, 889, 1090, 1221, 1224, 1319, 1332, 1402, 1519, 1615, 1722, 1840, 1879, 1913, 1967, 1974, 2424, 2448, 2542, 2555, 2664, 2692, 2706, 2735, 2817, 2921, 2936, 3078, 3125, 3135, 3270, 3411, 3420, 3437, 3447, 3468, 3696, 3712, 3801, 3814, 3911, 3991, 4024, 4052, 4061, 4094, 4346, 4439, 4664, 4819, 4834, 4843], 'as': [10, 181, 503, 510, 1140, 1142, 1473, 1788, 2048, 2058, 2327, 2778, 2944, 3102, 3557, 3586, 3733, 3766, 3844, 4259], 'ϵ-cleavage,': [11, 182, 1382, 4651], 'occurs': [12, 37, 183, 208, 3835], 'downstream': [13, 184], 'the': [15, 61, 81, 105, 126, 148, 161, 186, 232, 252, 276, 297, 319, 332, 346, 575, 586, 589, 626, 807, 895, 898, 903, 957, 960, 967, 1061, 1081, 1084, 1320, 1378, 1403, 1667, 1671, 1677, 1693, 1702, 1712, 1758, 1842, 1881, 1995, 2000, 2019, 2037, 2127, 2138, 2151, 2167, 2217, 2234, 2322, 2409, 2441, 2461, 2465, 2532, 2535, 2677, 2688, 2713, 2716, 2725, 2728, 2752, 2767, 2775, 2785, 2825, 2850, 2855, 2892, 2900, 2903, 2907, 3193, 3263, 3275, 3300, 3308, 3317, 3335, 3338, 3346, 3352, 3364, 3376, 3383, 3396, 3431, 3513, 3524, 3555, 3569, 3572, 3603, 3635, 3692, 3702, 3705, 3724, 3802, 3808, 3837, 3858, 3874, 3901, 3903, 3912, 3929, 3950, 3973, 4030, 4043, 4088, 4325, 4334, 4341, 4363, 4372, 4391, 4446, 4468, 4485, 4494, 4497, 4660, 4690, 4709, 4775, 4778, 4785, 4789, 4806, 4848], 'γ-cleavage': [16, 44, 165, 187, 215, 336, 1143, 3828, 4077, 4620], 'and': [17, 57, 74, 117, 133, 152, 155, 169, 188, 228, 245, 288, 304, 323, 326, 340, 457, 465, 474, 505, 594, 623, 625, 859, 915, 943, 1087, 1345, 1360, 1362, 1383, 1408, 1424, 1564, 1581, 1587, 1603, 1618, 1670, 1690, 1701, 1720, 1743, 1754, 1765, 1800, 1806, 1830, 1844, 1852, 1888, 1890, 1902, 1970, 1989, 2002, 2065, 2087, 2134, 2145, 2199, 2208, 2225, 2254, 2369, 2377, 2393, 2408, 2443, 2499, 2515, 2526, 2548, 2564, 2568, 2615, 2646, 2668, 2674, 2704, 2741, 2784, 2807, 2831, 2842, 2867, 2911, 3027, 3036, 3044, 3128, 3158, 3160, 3175, 3181, 3192, 3199, 3241, 3245, 3251, 3272, 3280, 3368, 3392, 3419, 3443, 3455, 3463, 3473, 3483, 3487, 3507, 3517, 3537, 3566, 3584, 3595, 3646, 3648, 3654, 3718, 3740, 3780, 3849, 3860, 3936, 3977, 3987, 4034, 4040, 4078, 4255, 4433, 4455, 4463, 4472, 4489, 4621, 4641, 4654, 4692, 4698, 4702, 4798, 4821, 4839], 'generates': [18, 189], 'predominantly': [19, 190, 1373, 1395, 2146, 2749, 2847, 3034, 3258, 3924], 'a': [20, 48, 110, 145, 191, 219, 281, 316, 475, 480, 511, 611, 812, 1065, 1077, 1114, 1341, 1349, 1363, 1385, 1648, 1770, 1789, 2042, 2049, 2091, 2118, 2159, 2170, 2200, 2421, 2510, 2520, 2609, 2659, 3022, 3161, 3327, 3496, 3664, 3854, 3862, 3998, 4073, 4360, 4627, 4636, 4666, 4810, 4836, 4844], 'C-terminal': [21, 192, 597, 1760, 1883], 'fragment': [22, 193, 598], '(CTFγ)': [23, 194], 'that': [24, 103, 134, 195, 274, 305, 608, 891, 920, 947, 1069, 2534, 2543, 2549, 2556, 2661, 2665, 2779, 2951, 3307, 3334, 3358, 3461, 3469, 3558, 3659, 3769, 3778, 3795, 3821, 3834, 3967, 3983, 4053, 4086, 4333, 4441, 4619, 4684, 4777, 4796, 4815], 'begins': [25, 87, 196, 258, 1070], 'at': [26, 88, 122, 197, 259, 293, 1071, 1611, 1626, 1647, 1663, 1824, 1833, 1999, 2318, 2774, 3202, 3326, 3359, 4482, 4689], 'Val-50,': [27, 198], 'according': [28, 199], 'amyloid': [30, 201, 361, 402, 439], 'β-protein': [31, 202, 440], '(Aβ)': [32, 203, 441], 'numbering.': [33, 204], 'Whether': [34, 205], 'this': [35, 206, 1328, 2228, 3660, 4063, 4442], 'independently': [38, 209], 'of,': [39, 210], 'or': [40, 79, 101, 211, 250, 272, 619, 1326, 1463, 1466, 1470, 1501, 1516, 1576, 1981, 2077, 2094, 2111, 2642, 3539, 3542, 3756, 4483, 4650, 4678, 4802, 4829], 'is': [41, 45, 212, 216, 472, 479, 489, 630, 860, 887, 897, 949, 1064, 1076, 1088, 1111, 1138, 1212, 1330, 1340, 1372, 1377, 1390, 1394, 2082, 2379, 2540, 2553, 2662, 2919, 3007, 3021, 3040, 3229, 3313, 3343, 3466, 3657, 3900, 3908, 4059, 4436, 4683, 4686, 4793], 'coordinated': [42, 213], 'with,': [43, 214], 'unknown.': [46, 217, 581], 'Using': [47, 218, 3057], 'cell-free': [49, 220, 1350, 2092, 2229], 'system,': [50, 221], 'we': [51, 222, 942, 1366, 2089, 2635, 2823, 3076, 3349, 3528, 3750, 3819, 4771], 'show': [52, 223, 1367, 3013], 'here': [53, 224, 1368], 'that,': [54, 225, 1369, 3009], 'although': [55, 226, 2687, 3010, 4056, 4770], 'Aβ40': [56, 115, 227, 286, 1371, 2116, 2311, 2376, 2538, 2657, 2693, 2845, 3032, 3257, 3367, 3434, 3462, 3976], 'CTFγ': [58, 84, 129, 136, 153, 229, 255, 300, 307, 324, 1066, 1110, 1344, 1375, 1392, 1766, 1861, 1866, 1892, 1944, 1987, 1990, 2026, 2066, 2095, 2204, 2255, 2388, 2400, 2413, 2438, 2455, 2503, 2507, 2545, 2558, 2566, 2616, 2633, 2701, 2720, 2731, 2755, 2770, 2808, 2872, 2889, 2916, 2942, 3019, 3037, 3055, 3065, 3085, 3093, 3111, 3143, 3179, 3187, 3210, 3223, 3237, 3266, 3322, 3341, 3379, 3390, 3393, 3471, 3474, 3488, 3492, 3499, 3526, 3647, 3676, 3689, 3708, 3727, 3759, 3787, 3866, 3878, 3916, 3932, 3969, 3985, 4004, 4009, 4021, 4046, 4258, 4338, 4375, 4428, 4642, 4668, 4671], '50–99': [59, 130, 230, 301, 1376, 1988, 2546, 2890, 3020, 3159, 3180, 3323, 3391, 3472, 3500, 3709, 3728, 3986], 'were': [60, 231, 1429, 1455, 1493, 1509, 1551, 1570, 1585, 1609, 1709, 1767, 1822, 1911, 1928, 1946, 1972, 1992, 2039, 2114, 2130, 2456, 2469, 2733, 2757, 2815, 2915, 3107, 3133, 3144, 3201, 3214, 3239, 3268, 3297, 3405, 3710, 3729, 4092, 4768], 'predominant': [62, 233, 2119, 3023], 'species': [63, 234, 453, 482, 1325, 2120, 2383, 2453, 2887, 3024, 3066, 3083, 3094, 3141, 3154, 3172, 3195, 3208, 3380, 3677, 3687, 3788, 4376, 4767], 'produced': [64, 235, 490, 2121, 2154, 2194, 2656, 2682, 2700, 2748, 2848, 3086, 3095, 3256, 3288, 3381, 3435, 3445, 3525, 3548, 3640, 3678, 3887, 3997, 4339], 'by': [65, 167, 236, 338, 499, 951, 1113, 1675, 1726, 1769, 1904, 1949, 2011, 2882, 3114, 3118, 3216, 3310, 3382, 3682, 3960, 4452, 4673, 4715], 'membranes': [66, 94, 237, 265, 2100, 2107, 2129, 2152, 2323, 2462, 2501, 2655, 2670, 2681, 2743, 2851, 2864, 2875, 2908, 3029, 3097, 3255, 3276, 3384, 3551, 3562, 3582, 3636, 3681, 3698, 3737, 3763, 3996, 4031, 4343, 4352], 'prepared': [67, 238, 1815, 2101, 2108, 2639], 'from': [68, 95, 239, 266, 491, 1083, 1794, 1816, 1994, 2072, 2102, 2109, 2131, 2166, 2324, 2440, 2622, 2640, 2795, 2828, 2852, 2865, 2874, 2909, 3098, 3415, 3424, 3439, 3449, 3637, 4032], 'cells': [69, 96, 240, 267, 1414, 1454, 1492, 1508, 1569, 1584, 1608, 1821, 2113, 2168, 2878, 2896, 2914, 2924, 2934, 3639, 4036], 'overexpressing': [70, 97, 241, 268, 2169], 'wild-type': [71, 242, 1419], '(wt)': [72, 243, 1420], 'APP': [73, 100, 244, 271, 584, 601, 919, 948, 1068, 1359, 1886, 2800, 3798, 3823], 'wt': [75, 246, 2641, 3538], 'presenilin': [76, 247, 616], '(PS)': [77, 248, 617], '1': [78, 249, 618, 1631, 1838, 1969, 3106, 3127, 3150], '2,': [80, 251, 620, 2672], 'production': [82, 106, 116, 121, 149, 253, 277, 287, 292, 320, 928, 1108, 1347, 2096, 2231, 2251, 2312, 2317, 2374, 2539, 2552, 2631, 2787, 2859, 3039, 3050, 3365, 3372, 3465, 3494, 3501, 3576, 3599, 3875, 3907, 3957, 4044, 4089, 4256, 4451], '49–99,': [85, 256, 2634, 2917, 3475], 'which': [86, 113, 257, 284, 1218, 1858, 1927, 2468, 2745, 2918, 3031, 3048, 3287, 4387], 'Leu-49,': [89, 260], 'was': [90, 261, 508, 1623, 1639, 1661, 1673, 1695, 1704, 1792, 1850, 1867, 1893, 2009, 2027, 2056, 2117, 2142, 2389, 2401, 2414, 2436, 2446, 2509, 2702, 2719, 2747, 2772, 2788, 2846, 2860, 2879, 2888, 3033, 3051, 3112, 3502, 3553, 3577, 3600, 3688, 3764, 3879, 3934, 4011], 'remarkably': [91, 262, 3731], 'enhanced': [92, 263, 2315], 'in': [93, 264, 463, 585, 866, 894, 902, 925, 956, 1553, 1589, 1641, 1654, 1802, 1854, 1935, 2041, 2070, 2239, 2240, 2321, 2458, 2497, 2513, 2523, 2608, 2620, 2724, 2744, 2764, 2780, 2838, 2849, 2863, 2891, 2906, 3025, 3030, 3042, 3047, 3096, 3104, 3188, 3231, 3316, 3337, 3395, 3491, 3498, 3504, 3549, 3560, 3580, 3679, 3691, 3715, 3761, 3770, 3846, 3873, 3894, 4014, 4018, 4029, 4340, 4362, 4371, 4493, 4626, 4762, 4784], 'mutant': [98, 269, 1117, 1425, 2173, 2211], '(mt)': [99, 270, 1426], 'mtPS1/2': [102, 273, 3045, 4035, 4356, 4456, 4462], 'increases': [104, 275], 'Aβ42.': [108, 279], 'Furthermore,': [109, 280, 1210, 3949], 'γ-secretase': [111, 282, 578, 609, 629, 1216, 1364, 2221, 2288, 3662, 4479], 'inhibitor,': [112, 283, 1365, 2289], 'suppresses': [114, 285], 'paradoxically': [118, 289, 2314, 3369], 'enhances': [119, 290], 'Aβ42': [120, 151, 291, 322, 892, 927, 1389, 2064, 2141, 2316, 2378, 2551, 2614, 2691, 2746, 2786, 2806, 2858, 3049, 3292, 3371, 3444, 3464, 3575, 3598, 3816, 3886, 3906, 3923, 3959, 3978, 4091, 4450, 4640], 'low': [123, 294, 2319, 3360], 'concentrations,': [124, 295], 'caused': [125, 166, 296, 337], 'proportion': [127, 298, 2139, 2398, 2411, 2856, 3221, 3339, 3377, 3432, 3573, 3884, 3930, 3974, 4373], 'decrease': [132, 303, 3497], '49–99': [137, 154, 308, 325, 1393, 1991, 2067, 2508, 2559, 2567, 2617, 2732, 2756, 2771, 2809, 3038, 3174, 3182, 3238, 3267, 3342, 3394, 3493, 3690, 3760, 3867, 3933, 3970, 4429, 4643], 'increase': [139, 310, 3336, 3490, 3872, 4087, 4379], 'significantly.': [140, 311], 'These': [141, 312, 3295, 3457, 4320], 'results': [142, 313, 2466, 3301, 3458, 3775, 3938, 4321], 'strongly': [143, 314, 3459, 3776], 'suggest': [144, 315, 3460, 3777], 'link': [146, 317, 1342, 4638], 'between': [147, 318, 1343, 2085, 4076, 4470, 4639, 4850], 'provide': [156, 327], 'an': [157, 328, 1975, 2059, 2802, 2818, 2949, 3058, 3088, 3356, 3520, 3783, 3963, 4369, 4378, 4423], 'important': [158, 329], 'insight': [159, 330], 'into': [160, 331, 2391, 2403], 'mechanisms': [162, 333, 4447], 'altered': [164, 335], 'mtAPP': [168, 339, 2076, 2132, 2524, 3043, 3278, 3482, 3516, 3533, 3594, 3779, 3851, 4015, 4033, 4454, 4464], 'mtPS1/2.': [170, 341], 'Senile': [342], 'plaques,': [343], 'one': [344, 4657], 'neuropathological': [347], 'hallmarks': [348], "Alzheimer's": [350, 358, 399], 'disease': [351], '(AD),': [352], '1The': [353, 394], 'abbreviations': [354, 395], 'used': [355, 396, 2057, 2090], 'are:': [356, 397], 'AD,': [357, 398], 'disease;': [359, 400], 'Aβ,': [360, 401], 'β-protein;': [362, 403], 'APP,': [363, 404], 'protein;': [366, 407], 'PS,': [367, 408], 'presenilin;': [368, 409], 'CTF,': [369, 410], 'carboxyl-terminal': [370, 411], 'fragment;': [371, 412], 'CHO,': [372, 413], 'Chinese': [373, 414], 'hamster': [374, 415, 1411], 'ovary;': [375, 416], 'HEK,': [376, 417], 'human': [377, 418], 'embryonic': [378, 419, 1505], 'kidney;': [379, 420], 'wt,': [380, 421, 1461, 1467, 1499, 1514, 2829], 'wild': [381, 422], 'type;': [382, 423], 'mt,': [383, 424], 'mutant;': [384, 425], 'RP-HPLC,': [385, 426], 'reverse-phase': [386, 427, 1950], 'high': [387, 428, 1951], 'performance': [388, 429, 1952], 'liquid': [389, 430, 1953], 'chromatography;': [390, 431], 'Pipes,': [391, 432, 1594], '1,4-piperazinediethanesulfonic': [392, 433], 'acid.': [393, 434], 'are': [435, 460, 1219, 3746, 4322, 4344, 4480, 4491, 4623, 4704, 4787], 'composed': [436, 614], 'primarily': [437], '(1Selkoe': [442], 'D.J.': [443, 1131, 1445, 1544, 2186, 2302, 2341, 3627], 'Physiol.': [444], 'Rev.': [445, 643, 935], '2001;': [446, 987, 1009, 1030, 1162, 1183, 1241, 1263, 1284, 2362, 2490, 2973, 4530, 4757], '81:': [447], '741-766Google': [448], 'Scholar).': [449, 804, 885, 940, 1056, 1106, 1209, 1310, 1452, 1490, 1549, 2493, 3002, 3633, 4319, 4616, 4760], 'Two': [450], 'major': [451, 1058, 1379, 2521, 2886, 2904, 3686], 'Aβ': [452, 486, 488, 593, 808, 1324, 1346, 1784, 2093, 2162, 2230, 2235, 2253, 3486, 3645, 3806, 4713, 4766], 'consisting': [454, 2098], '40': [456], '42': [458], 'residues': [459, 1079, 1761], 'generated': [461, 2387, 3861, 3922], 'mainly': [462], 'neurons': [464], 'constitutively': [466], 'secreted.': [467, 4705], 'shorter': [469], 'one,': [470, 477], 'Aβ40,': [471], 'predominant,': [473], 'longer': [476, 4669, 4765], 'Aβ42,': [478, 810, 2686, 4055], 'minor': [481, 2511], '(<10%)': [483], 'among': [484, 2695, 3016, 3942], 'secreted': [485], 'species.': [487], 'through': [496], 'sequential': [497], 'proteases': [500], 'β-': [504], 'γ-secretases.': [506], 'β-Secretase': [507], 'identified': [509, 2457, 3145, 4476], 'type': [512, 4631], 'I': [513, 3250, 4632], 'membrane': [514, 969, 1082, 1637, 1645, 2637, 2826, 2893, 3404, 3839, 4487, 4633, 4813], 'aspartic': [515], 'protease': [516, 1658], 'β-site': [517], 'APP-cleaving': [518], 'enzyme': [519], '(BACE)': [520], '(2Vassar': [521], 'R.': [522, 540, 700, 718, 750, 1024, 1101, 1177, 1278, 1483, 2275, 2967, 4202, 4505], 'Bennett': [523], 'B.D.': [524], 'Babu-Khan': [525], 'S.': [526, 528, 536, 544, 548, 656, 704, 770, 789, 1037, 1190, 1291, 2986, 4109, 4147, 4168, 4216, 4249, 4270, 4314, 4404, 4543, 4551, 4565], 'Kahn': [527], 'Mendiaz': [529], 'E.A.': [530, 4753], 'Denis': [531], 'P.': [532, 538, 682, 708, 711, 2988, 2995, 3623, 4111, 4118, 4180, 4187, 4272, 4279, 4406, 4413, 4535, 4549], 'Teplow': [533, 1003, 1156, 1257, 1442, 1541, 4199], 'D.B.': [534, 1004, 1157, 1258, 1443, 1542, 4200], 'Ross': [535], 'Amarante': [537], 'Loeloff': [539], 'Luo': [541], 'Y.': [542, 684, 698, 880, 973, 983, 1227, 1237, 1477, 1485, 2269, 2277, 2356, 2476, 2486, 2980, 4103, 4176, 4264, 4398, 4514], 'Fisher': [543], 'Fuller': [545], 'J.': [546, 550, 564, 722, 728, 742, 779, 798, 822, 827, 841, 847, 852, 984, 1027, 1180, 1238, 1281, 1446, 2187, 2303, 2342, 2487, 2970, 2996, 4119, 4196, 4231, 4280, 4296, 4414, 4527, 4537, 4559, 4579, 4584, 4612, 4740], 'Edenson': [547], 'Lile': [549], 'Jarosinski': [551], 'M.A.': [552], 'Biere': [553], 'A.L.': [554, 738], 'Curran': [555], 'E.': [556, 666, 680, 692, 766, 2360, 4174, 4178, 4225, 4290], 'Burgess': [557], 'T.': [558, 670, 870, 977, 1018, 1171, 1231, 1272, 1481, 2182, 2273, 2480, 2961, 4166, 4223, 4288, 4518, 4522, 4555, 4600, 4602, 4604, 4606], 'Louis': [559], 'J.C.': [560], 'Collins': [561], 'F.': [562, 668, 2978, 4101, 4162, 4262, 4396], 'Treanor': [563], 'Rogers': [565], 'G.': [566, 652, 720, 772, 797, 1000, 1045, 1051, 1153, 1198, 1204, 1254, 1299, 1305, 2354, 3619, 4135, 4158, 4198, 4539], 'Citron': [567, 2293, 2332], 'M.': [568, 654, 694, 726, 730, 732, 744, 776, 839, 843, 992, 1041, 1145, 1194, 1246, 1295, 1479, 2271, 2294, 2333, 3607, 4160, 4567, 4569, 4592, 4608], 'Science.': [569], '1999;': [570, 1133], '286:': [571], '735-741Google': [572], 'Scholar),': [573, 1136, 2193, 2309], 'but': [574, 964, 2313, 3204, 4367, 4421], 'identity': [576], 'has': [579, 811, 1313, 3519, 3663, 3791], 'remained': [580, 1314], 'γ-Secretase': [582], 'cleaves': [583], 'middle': [587, 958, 4495], 'transmembrane': [590, 961, 4498], 'domain,': [591], 'releasing': [592], 'its': [595], 'counterpart,': [596], 'γ': [599], '(CTFγ).': [602], 'Most': [603], 'recent': [604, 4068], 'studies': [605, 4707], 'have': [606, 3782, 4070], 'shown': [607, 2837, 3103, 3845], 'forms': [610], 'large': [612, 1386, 2213, 3863, 3871, 4425], 'complex': [613], 'nicastrin,': [621], 'PEN-2,': [622], 'APH-1,': [624], 'activity': [627], 'now': [631], 'known': [632, 1220], 'depend': [634], 'on': [635, 1680, 1916, 1956, 2018, 3067, 3375, 3485, 3523, 3597, 3786, 3832, 3857, 4330], 'these': [636, 2813, 3004, 3680, 3722, 3762, 3774], 'proteins': [637, 1708], '(3Steiner': [638], 'H.': [639, 676, 764, 791, 876, 975, 994, 1020, 1147, 1173, 1229, 1248, 1274, 2478, 2963, 2982, 2992, 4105, 4115, 4204, 4208, 4237, 4243, 4266, 4276, 4302, 4308, 4400, 4410, 4526, 4581, 4594, 4598], 'Haass': [640, 777, 1005, 1158, 1259, 4209, 4240, 4305, 4582, 4609], 'C.': [641, 690, 696, 752, 778, 793, 818, 849, 851, 1006, 1014, 1159, 1167, 1260, 1268, 1524, 1530, 2957, 3613, 4182, 4210, 4235, 4241, 4300, 4306, 4571, 4583, 4610], 'Nat.': [642, 934], 'Mol.': [644, 828], 'Cell.': [645, 758], 'Biol.': [646, 780, 799, 829, 853, 985, 1028, 1181, 1239, 1282, 1447, 2188, 2488, 2971, 2997, 4120, 4281, 4415, 4529, 4585], '2000;': [647, 713, 2190, 4189, 4218, 4742], '1:': [648], '217-224Google': [649], 'Scholar,': [650, 716, 762, 785, 833, 990, 1012, 1033, 1165, 1186, 1244, 1266, 1287, 2348, 2976, 4125, 4152, 4192, 4221, 4286, 4510, 4533, 4563, 4590, 4745], '4Yu': [651], 'Nishimura': [653, 4159], 'Arawaka': [655, 2985, 4108, 4167, 4269, 4403], 'Levitan': [657, 4155], 'D.': [658, 756, 768, 835, 1540, 2990, 4113, 4127, 4131, 4156, 4229, 4274, 4294, 4408, 4516, 4577], 'Zhang': [659, 685, 697, 721, 4183], 'L.': [660, 674, 1022, 1175, 1276, 2350, 2352, 2965, 4184, 4194, 4547], 'Tandon': [661, 4163], 'A.': [662, 672, 706, 774, 845, 872, 998, 1035, 1151, 1188, 1252, 1289, 1532, 4148, 4164, 4170, 4206, 4217, 4233, 4250, 4298, 4315, 4541, 4573, 4596, 4747, 4749], 'Song': [663, 2351, 4171], 'Y.Q.': [664, 4172], 'Rogaeva': [665, 4173], 'Chen': [667, 4161], 'Kawarai': [669, 4165], 'Supala': [671, 4169], 'Levesque': [673, 3618], 'Yu': [675, 792, 796, 4157], 'Yang': [677], 'D.S.': [678], 'Holmes': [679, 4177], 'Milman': [681, 4179], 'Liang': [683, 4175], 'D.M.': [686, 4154], 'Xu': [687, 739, 1019, 1172, 1273, 2962], 'D.H.': [688], 'Sato': [689, 976, 1230, 1480, 2272, 2479, 4181], 'Rogaev': [691], 'Smith': [693], 'Janus': [695], 'Aebersold': [699], 'Farrer': [701], 'L.S.': [702, 4755], 'Sorbi': [703], 'Bruni': [705], 'Fraser': [707, 2987, 4110, 4271, 4405], 'St.': [709, 931, 2993, 3620, 4116, 4185, 4277, 4411], 'George-Hyslop': [710, 932, 2994, 4117, 4186, 4278, 4412], 'Nature.': [712, 1102, 1132, 1545, 4506, 4756], '407:': [714], '48-54Google': [715], '5Francis': [717], 'McGrath': [719], 'Ruddy': [723], 'D.A.': [724], 'Sym': [725], 'Apfeld': [727], 'Nicoll': [729], 'Maxwell': [731], 'Hai': [733], 'B.': [734, 820, 837, 2358, 4239, 4304], 'Ellis': [735], 'M.C.': [736], 'Parks': [737], 'W.': [740, 795, 1123, 2180, 2298, 2337, 3617], 'Li': [741, 790], 'Gurney': [743], 'Myers': [745], 'R.L.': [746], 'Himes': [747], 'C.S.': [748], 'Hiebsch': [749], 'Ruble': [751], 'Nye': [753], 'J.S.': [754], 'Curtis': [755], 'Dev.': [757], '2002;': [759, 782, 801, 937, 1053, 1206, 1307, 2999, 4122, 4251, 4283, 4316, 4417, 4560, 4587, 4613], '3:': [760, 938], '85-97Google': [761], '6Steiner': [763], 'Winkler': [765, 4224, 4289], 'Edbauer': [767, 4228, 4293, 4576], 'Prokop': [769], 'Basset': [771], 'Yamasaki': [773], 'Kostka': [775], 'Chem.': [781, 800, 854, 986, 1029, 1182, 1240, 1283, 1448, 2189, 2305, 2344, 2489, 2972, 2998, 4121, 4282, 4416, 4586], '277:': [783, 802, 3000, 4123, 4284, 4418, 4588], '39062-39065Google': [784], '7Lee': [786], 'S.F.': [787], 'Shah': [788], 'Han': [794], '45013-45019Google': [803], 'One': [805, 4680], 'species,': [809, 3527], 'much': [813, 2758, 3641, 3758], 'higher': [814, 2759], 'aggregation': [815], 'potential': [816, 4637], '(8Hilbich': [817], 'Kisters-Woike': [819], 'Reed': [821], 'Masters': [823, 1046, 1199, 1300], 'C.L.': [824, 1047, 1200, 1301], 'Beyreuther': [825, 1048, 1201, 1302], 'K.': [826, 981, 996, 1043, 1049, 1149, 1196, 1202, 1235, 1250, 1297, 1303, 2484], '1991;': [830], '218:': [831], '149-163Google': [832], '9Burdick': [834], 'Soreghan': [836], 'Kwon': [838], 'Kosmoski': [840], 'Knauer': [842], 'Henschen': [844], 'Yates': [846], 'Cotman': [848], 'Glabe': [850], '1992;': [855, 1546], '267:': [856], '546-554Google': [857], 'Scholar)': [858, 2282, 2365, 4254, 4420], 'believed': [861], 'be': [863, 1400, 2736, 3073, 3713, 3940, 4025, 4050, 4817], 'initially': [864], 'deposited': [865], 'senile': [867], 'plaques': [868], '(10Iwatsubo': [869], 'Odaka': [871], 'Suzuki': [873], 'N.': [874, 878, 979, 1233, 2482, 4520], 'Mizusawa': [875], 'Nukina': [877], 'Ihara': [879, 982, 1236, 1484, 2276, 2485], 'Neuron.': [881], '1994;': [882], '13:': [883], '45-53Google': [884], 'It': [886, 3656, 3790, 4435, 4792], 'reasonable': [888, 4438], 'postulate': [890], 'accumulation': [893], 'brain': [896], 'very': [899, 2257, 3314, 4026], 'initial': [900], 'event': [901], 'development': [904], 'AD': [906, 923, 1356], 'including': [907], 'sporadic': [908], 'AD.': [909], 'Indeed,': [910], 'all': [911, 2929], 'mutations': [912, 917, 1357, 2696, 3796, 3824, 3944, 4085], 'PS1/2': [914, 1225, 1361], 'some': [916, 3014, 4490], 'cause': [921], 'familial': [922, 1355], 'result': [924], 'increased': [926, 2143, 2630, 2791, 2862, 3041, 3269, 3289, 3370, 3579, 3765, 3815, 3883, 3956, 4013, 4028, 4449], '(11Sisodia': [929], 'S.S.': [930, 1026, 1179, 1280, 2969, 4139], 'P.H.': [933], 'Neurosci.': [936], '281-290Google': [939], 'Recently,': [941], 'other': [944, 1882, 2678, 2901, 3570, 3703, 3943], 'groups': [945], 'found': [946, 2734, 3711, 4093], 'cleaved': [950, 4481, 4688, 4694], 'PS-dependent': [952, 1139], 'γ-secretase,': [953, 3812], 'not': [954, 1863, 2248, 2284, 3072, 3747, 3752, 3909, 3980, 4358, 4389], 'only': [955, 2789, 4359], 'domain': [962, 4499], '(γ-cleavage)': [963], 'also': [965, 1213, 2153, 3730, 4049, 4368, 4492, 4794], 'near': [966, 3836, 4484], 'cytoplasmic': [968, 3838, 4486], 'boundary': [970, 1086], '(ϵ-cleavage)': [971], '(12Gu': [972, 1226, 2475], 'Misonou': [974, 1228, 2477], 'Dohmae': [978, 1232, 2481], 'Takio': [980, 1234, 2483], '276:': [988, 1031, 1184, 1242, 1285, 2491, 2974], '35235-35238Google': [989, 1243, 2492], '13Sastre': [991, 1245], 'Steiner': [993, 1146, 1247, 4207, 4242, 4307, 4580, 4593], 'Fuchs': [995, 1148, 1249], 'Capell': [997, 1150, 1251, 4205, 4232, 4297, 4572], 'Multhaup': [999, 1152, 1253, 4197], 'Condron': [1001, 1154, 1255], 'M.M.': [1002, 1155, 1256], 'EMBO': [1007, 1160, 1261, 4558, 4611], 'Rep.': [1008, 1161, 1262], '2:': [1010, 1163, 1264], '835-841Google': [1011, 1164, 1265], '14Yu': [1013, 1166, 1267], 'Kim': [1015, 1168, 1269, 2958], 'S.H.': [1016, 1169, 1270, 2959], 'Ikeuchi': [1017, 1170, 1271, 2960], 'Gasparini': [1021, 1174, 1275, 2964], 'Wang': [1023, 1176, 1277, 2966], 'Sisodia': [1025, 1178, 1279, 2968, 4138], '43756-43760Google': [1032, 1185, 1286, 2975], '15Weidemann': [1034, 1187, 1288], 'Eggert': [1036, 1189, 1290], 'Reinhard': [1038, 1191, 1292], 'F.B.': [1039, 1192, 1293], 'Vogel': [1040, 1193, 1294], 'Paliga': [1042, 1195, 1296], 'Baier': [1044, 1197, 1298], 'Evin': [1050, 1203, 1304], 'Biochemistry.': [1052, 1205, 1306, 1486, 2278, 2361], '41:': [1054, 1207, 1308, 2307, 2346], '2825-2835Google': [1055, 1208, 1309], 'The': [1057, 1621, 1633, 1644, 1706, 1847, 1907, 1964, 2386, 2494, 2871, 2885, 3092, 3122, 3219, 3234, 3387, 3544, 3685, 4458], 'product': [1059, 1380], 'latter': [1062], 'process': [1063], 'Val-50.': [1072], 'This': [1073, 2210, 2530, 3590, 3870, 4383, 4617], 'site': [1075, 1091, 4080, 4097], 'few': [1078], 'inside': [1080], 'cytoplasmic/membrane': [1085], 'similar': [1089, 2258, 2663, 2920, 3937], '3': [1092, 4081, 4098], 'Notch': [1095, 4079, 4096], '(16Schroeter': [1096, 4500], 'E.H.': [1097, 1439, 1538, 4501], 'Kisslinger': [1098, 4502], 'J.A.': [1099, 4503], 'Kopan': [1100, 4504], '1998;': [1103, 2306, 2345, 3630, 4507], '393:': [1104, 4508], '382-386Google': [1105, 4509], 'Since': [1107], 'inhibited': [1112, 1214, 3363], 'dominant': [1115, 2171], 'negative': [1116, 2172], 'PS1': [1119, 1472, 3946, 4084], '(17Wolfe': [1120], 'M.S.': [1121, 2184, 2292, 2331], 'Xia': [1122, 2179, 2297, 2336, 3616, 4226, 4291], 'Ostaszewski': [1124, 1434, 1533, 3614], 'B.L.': [1125, 1435, 1534, 3615], 'Diehl': [1126, 2295, 2334, 3610], 'T.S.': [1127, 2296, 2335, 3611], 'Kimberly': [1128], 'W.T.': [1129, 2178], 'Selkoe': [1130, 1444, 1543, 2185, 2301, 2340, 3626], '398:': [1134], '513-517Google': [1135], 'ϵ-cleavage': [1137, 1211, 1317, 1398, 3011, 3833, 3859, 4366, 4394, 4622, 4799, 4830], 'well': [1141, 4260], '(13Sastre': [1144], 'with': [1215, 1416, 1458, 1496, 1511, 1559, 1573, 1687, 1697, 1711, 1870, 1895, 1898, 1930, 2029, 2261, 2381, 2431, 2471, 2946, 2953, 3299, 3430, 3588, 3602, 3735, 3768, 4324, 4385], 'inhibitors,': [1217], 'selectively': [1222], 'bind': [1223], 'However,': [1311, 3773, 3841, 4761], 'it': [1312, 2518, 3006], 'unknown': [1315], 'how': [1316, 3757, 4655], 'relates': [1318], 'generation': [1321], 'distinct': [1323], 'whether': [1327, 1338, 2080, 2373, 2812, 3512, 3755], 'step': [1329, 2423], 'essential': [1331], 'generate': [1333], 'Aβ.': [1334], 'We': [1335, 2371, 3673, 4662], 'therefore': [1336, 4437], 'examined': [1337, 2636, 2824, 3351], 'there': [1339, 2081], 'using': [1348, 1729, 1779, 2045, 3087], 'system.': [1351], 'Taking': [1352], 'advantage': [1353], 'when': [1370, 1384, 2126], 'produced,': [1374, 1391, 3035], 'amount': [1387, 2202, 3163, 3864, 4000, 4426], 'produced.': [1396, 3789], 'Thus,': [1397, 2227, 3075, 3972, 4042, 4355], 'may': [1399, 3012, 3071, 4048], 'linked': [1401], 'specificity': [1404, 3810], 'γ-cleavage.': [1406], 'APP-': [1407], 'PS1/2-overexpressing': [1409], 'Cells—Chinese': [1410], 'ovary': [1412], '(CHO)': [1413], 'transfected': [1415, 1457, 1495, 1510, 1567], 'cDNA': [1417, 1459, 1497, 1512], 'encoding': [1418, 1460, 1498, 1513], 'APP751': [1421, 1427], '(7WD10': [1422], 'cells)': [1423, 3896], '(V717F)': [1428, 2133, 2525, 3279, 3852], 'described': [1430, 1474], 'previously': [1431, 1475, 2328], '(18Podlisny': [1432], 'M.B.': [1433], 'Squazzo': [1436], 'S.L.': [1437], 'Koo': [1438, 1537], 'Rydell': [1440], 'R.E.': [1441], '1995;': [1449], '270:': [1450], '9564-9570Google': [1451], '7WD10': [1453], 'further': [1456, 1494, 1571, 1624, 1947, 2627, 3332, 4057, 4466, 4645], 'N141I,': [1462], 'D366A': [1464, 2176], 'PS2': [1465], 'M146L,': [1468], 'M233T,': [1469, 1500, 2645], 'G384A': [1471, 1502, 2742], '(19Qi': [1476, 2268], 'Morishima-Kawashima': [1478, 2270], 'Mitsumori': [1482, 2274], '2003;': [1487, 2279], '42:': [1488, 2280], '1042-1052Google': [1489, 2281], 'V717F': [1491, 1517, 2832, 2868, 3671, 3697, 3893], 'PS1.': [1503], 'Human': [1504], 'kidney': [1506], 'HEK293': [1507, 2796, 2834, 2877, 2913, 2933, 3994], 'V717G,': [1515, 2830], '(according': [1518], 'APP770': [1520], 'numbering)': [1521], 'APP695': [1522], '(20Haass': [1523], 'Schlossmacher': [1525], 'M.G.': [1526], 'Hung': [1527], 'A.Y.': [1528], 'Vigo-Pelfrey': [1529], 'Mellon': [1531], 'Lieberburg': [1535], 'I.': [1536, 3233, 4141, 4512], 'Schenk': [1539], '359:': [1547], '322-325Google': [1548], 'Cells': [1550, 2074, 2624, 2797], 'maintained': [1552], "Dulbecco's": [1554], 'modified': [1555], "Eagle's": [1556], 'medium': [1557], 'supplemented': [1558], '10%': [1560], 'fetal': [1561], 'bovine': [1562, 2053], 'serum': [1563], 'penicillin/streptomycin.': [1565], 'Stably': [1566], 'CHO': [1568, 2073, 2623, 2821, 2923, 2947, 3895, 3992, 4019], 'added': [1572], 'G418,': [1574], 'zeocin,': [1575], 'puromycin': [1577], '(Invitrogen).': [1578], 'Cell-free': [1579, 2250], 'Assay': [1580], 'Inhibitor': [1582], 'Treatment—Confluent': [1583], 'harvested': [1586], 'homogenized': [1588, 1853], 'homogenization': [1590, 1642, 1655], 'buffer': [1591, 1656, 1715, 1939], '(20': [1592], 'mm': [1593, 1598, 1605, 1937], 'pH': [1595], '7.0,': [1596], '140': [1597], 'KCl,': [1599], '0.25': [1600], 'm': [1601, 1718, 1932], 'sucrose,': [1602], '5': [1604], 'EGTA).': [1606], 'Homogenized': [1607], 'centrifuged': [1610], '800': [1612], '×': [1613, 1628, 1835], 'g': [1614, 1629, 1836], 'remove': [1616, 1880], 'nuclei': [1617], 'cell': [1619, 2245, 2930, 3017, 3100, 3190, 3227, 3347, 3995], 'debris.': [1620], 'supernatant': [1622], 'ultracentrifuged': [1625, 1832], '100,000': [1627, 1834], 'for': [1630, 1666, 1733, 1737, 1745, 1827, 1837, 2220, 2651, 2730, 2754, 2769, 3063, 3184, 3225, 3243, 3274, 3670, 3707, 3892, 4072, 4448, 4827], 'h.': [1632], 'resultant': [1634], 'pellet,': [1635], 'total': [1636, 1747, 4335], 'fraction,': [1638], 'suspended': [1640, 1851], 'buffer.': [1643], 'fraction': [1646, 1849, 2405, 3398], 'concentration': [1650], '2.5': [1652], 'mg/ml': [1653], 'containing': [1657, 1716], 'inhibitor': [1659, 3357], 'mixture': [1660, 1679], 'incubated': [1662, 1823, 2128], '37': [1664, 1825], '°C': [1665, 1826], 'indicated': [1668], 'time,': [1669], 'reaction': [1672, 1678], 'stopped': [1674], 'placing': [1676], 'ice.': [1681], 'After': [1682], 'extraction': [1683], 'lipids': [1685], 'twice': [1686], 'chloroform/methanol': [1688], '(2:1)': [1689], 'chloroform/methanol/water': [1691], '(1:2:0.8),': [1692], 'residue': [1694], 'extracted': [1696, 1860, 1897, 2028], '70%': [1698, 1899], 'formic': [1699, 1900], 'acid,': [1700, 1901, 2032], 'extract': [1703], 'dried.': [1705], 'remaining': [1707, 2410, 3194], 'dissolved': [1710, 1801], 'SDS': [1713], 'sample': [1714], '9': [1717], 'urea': [1719], 'subjected': [1721, 1912, 1973, 2447, 2705, 3134], '16.5%': [1723], 'SDS-PAGE,': [1724], 'followed': [1725, 3117], 'Western': [1727], 'blotting': [1728], 'antibodies': [1730], 'BA27': [1731], '(specific': [1732, 1736], 'Aβ40),': [1734], 'BC05': [1735], 'Aβ42),': [1738], '6E10': [1739], '(raised': [1740, 1756], 'against': [1741, 1757], 'Aβ1–16,': [1742], 'appropriate': [1744], 'assessing': [1746], 'Aβ;': [1748], 'Senetek': [1749, 1874], 'PLC,': [1750, 1875], 'Maryland': [1751, 1876], 'Heights,': [1752, 1877], 'MO),': [1753], 'C4': [1755, 2432], '30': [1759, 1828], 'APP).': [1763], 'Aβ40/42': [1764, 2086, 2198, 3547, 4703], 'quantified': [1768, 1993], 'LAS-1000plus': [1771], 'luminescent': [1772], 'image': [1773], 'analyzer': [1774], '(Fuji': [1775], 'Film,': [1776], 'Tokyo,': [1777, 1925, 1962], 'Japan)': [1778], 'defined': [1780], 'amounts': [1781, 2156, 2196, 2214, 2684, 2940, 3290, 3643, 4336], 'authentic': [1783], '(Bachem,': [1785], 'Bubendorf,': [1786], 'Switzerland)': [1787], 'standard.': [1790, 2061], 'DFK-167': [1791, 2290, 3955], 'purchased': [1793], 'Enzyme': [1795], 'Systems': [1796], 'Products': [1797], '(Livermore,': [1798], 'CA)': [1799], 'Me2SO.': [1803], 'Mass': [1804, 2006], 'Spectrometric': [1805], 'Amino': [1807, 3059], 'Acid': [1808, 3060], 'Sequence': [1809], 'Analyses': [1810], 'CTFγ—': [1812], 'Membrane': [1813], 'fractions': [1814, 1945, 1965, 2445, 2638, 2827, 3123], '80': [1817], 'dishes': [1818], 'cultured': [1820], 'min': [1829, 2267], 'then': [1831, 1891, 4840], 'h': [1839], 'separate': [1841], 'soluble': [1843, 2392, 2404, 2442, 2563, 3397], 'membrane-bound': [1845, 1848, 2394, 2416, 2444, 2565], 'CTFγ.': [1846, 2385], '1%': [1855, 2030], 'Triton': [1856], 'X-100,': [1857], 'completely': [1859], '(data': [1862, 2247, 2283], 'shown).': [1864, 2249, 2285], 'Solubilized': [1865], 'immunoprecipitated': [1868, 1894, 2439, 2703, 2873], 'once': [1869], '4G8': [1871], '(epitope:': [1872], 'Aβ17–24;': [1873], 'MO)': [1878], 'fragments': [1884], '(CTFα': [1887], 'CTFβ),': [1889], 'C4,': [1896], 'dried': [1903], 'vacuum': [1905], 'centrifugation.': [1906], 'partially': [1908], 'purified': [1909, 1948], 'samples': [1910], 'gel': [1914, 3115], 'filtration': [1915], 'two': [1917, 3170, 4851], 'tandemly': [1918], 'arrayed': [1919], 'TSK-gel': [1920], 'Super': [1921], 'SW2000': [1922], 'columns': [1923], '(Tosoh,': [1924], 'Japan),': [1926], 'developed': [1929], '6': [1931], 'guanidine': [1933], 'hydrochloride': [1934], '10': [1936, 3400, 3953], 'phosphate': [1938], '(pH': [1940], '6.0).': [1941], 'Pooled': [1942], 'putative': [1943], 'chromatography': [1954], '(RP-HPLC)': [1955], 'CAPCELL': [1957], 'PAK': [1958], 'Phenyl': [1959], 'SG300': [1960], '(Shiseido,': [1961], 'Japan).': [1963], 'corresponding': [1966, 3124], 'peaks': [1968, 2729, 2753, 2905, 3126, 3706, 3725], '2': [1971, 3129, 3168], 'Applied': [1976], 'Biosystems': [1977], 'model': [1978, 1982], '494': [1979], 'cLC': [1980], '492': [1983], 'sequencer.': [1985, 3091], 'Both': [1986, 3254], 'yields': [1996], 'Val-50': [1998], 'first': [2001, 2422, 4687], 'second': [2003], 'cycles,': [2004], 'respectively.': [2005], 'spectrometric': [2007, 2450, 2708, 3069, 3304, 3744, 4676, 4717], 'analysis': [2008, 2709, 4677, 4718], 'performed': [2010], 'matrix-assisted': [2012], 'laser': [2013], 'desorption/ionization': [2014], 'time-of-flight': [2015], 'mass': [2016, 2449, 2707, 2883, 3068, 3303, 3311, 3683, 3743, 4675, 4716], 'spectrometry': [2017, 3312], 'Voyager': [2020], 'Biospectrometry': [2021], 'Workstation': [2022], '(Applied': [2023], 'Biosystems).': [2024], 'Immunoprecipitated': [2025], 'trifluoroacetic': [2031], '30%': [2033], 'acetonitrile.': [2034], 'Masses': [2035], 'peptides': [2038], 'determined': [2040], 'linear': [2043], 'mode,': [2044], 'sinapinic': [2046], 'acid': [2047, 3090, 3137], 'matrix.': [2050], 'For': [2051, 3918], 'calibration,': [2052], 'insulin': [2054], '(Sigma)': [2055], 'external': [2060], 'Production': [2062, 2612, 2804], 'Is': [2068, 2618, 3324], 'Increased': [2069, 2619, 2803], 'Membranes': [2071, 2165, 2621, 2794], 'Expressing': [2075, 2625, 2798], 'mtPS2—To': [2078], 'learn': [2079], 'any': [2083], 'relationship': [2084, 4075, 4469, 4849], 'CTFγ,': [2088, 2158, 2427, 4003], 'system': [2097, 2232], 'various': [2103], 'stable': [2104, 3530], 'transfectants.': [2105], 'When': [2106], 'wtAPP-overexpressing': [2110, 2853, 2895], 'wtPS2-overexpressing': [2112], 'incubated,': [2115], '(Fig.': [2122, 2147, 2163, 2205, 2222, 2366, 2463, 2671, 2697, 2710, 2750, 2760, 2782, 2792, 2897, 3120, 3259, 3293, 3373, 3477, 3563, 3651, 3699, 3897, 3947, 4006, 4430], '1A).': [2123, 2148, 3260, 3294, 3898], 'In': [2124, 2712, 2722, 2739, 2762, 3261, 3721, 3989], 'contrast,': [2125, 2723, 2763, 3262], 'mtPS2': [2135, 2527, 3281, 3920, 4342], '(N141I)': [2136, 2528, 3282, 3921], 'cells,': [2137, 2326, 2822, 2854, 2948, 3283, 3993, 4020], 'specifically': [2144, 3362], 'Besides': [2149], 'Aβ40/42,': [2150], 'comparable': [2155], 'counterpart': [2160], '1B).': [2164], 'PS2,': [2175], '(21Kimberly': [2177], 'Rahmati': [2181], 'Wolfe': [2183], '275:': [2191], '3173-3178Google': [2192], 'negligible': [2195, 3205], 'trace': [2201, 3162], '1,': [2206, 2223, 2367], 'B).': [2209, 2226, 2675, 3567, 3655], 'accumulated': [2212, 3649], 'CTFα/β,': [2216], 'immediate': [2218], 'substrates': [2219, 4477], 'reflects': [2233], 'secretion': [2236], 'profile': [2237], 'observed': [2238, 3503, 3559], 'vitro': [2241], 'culture': [2242], 'each': [2244, 2459, 3081, 3189, 3226, 4453], 'line': [2246, 3228], 'took': [2256], 'time': [2259], 'courses,': [2260], 'both': [2262, 3285, 3716], 'gradually': [2263], 'declining': [2264], 'after': [2265], '10–20': [2266], 'specific': [2287, 4825], '(22Wolfe': [2291, 2330], 'Donkor': [2299, 2338], 'I.O.': [2300, 2339], 'Med.': [2304, 2343], '6-9Google': [2308, 2347], 'suppressed': [2310], 'concentrations': [2320, 3361], 'wtPS2': [2325, 2500, 2516, 2669, 3246, 3403, 4351], 'reported': [2329, 4708], '23Zhang': [2349], 'Terracina': [2353], 'Liu': [2355], 'Pramanik': [2357], 'Parker': [2359], '40:': [2363], '5049-5055Google': [2364], 'C': [2368, 3803], 'D).': [2370], 'wondered': [2372], 'correlated': [2380], 'particular': [2382, 4443, 4628, 4667, 4837], 'separated': [2390], 'forms.': [2395], 'larger': [2397, 2683, 2939], 'released': [2402], 'during': [2406], 'incubation,': [2407], 'left': [2415], '(see': [2417, 2433, 2925, 3130, 3146], 'Table': [2418, 3232], 'I).': [2419, 3386, 4354], 'As': [2420, 2836, 3899], 'purification': [2425], 'highly': [2428], 'efficient': [2429], 'immunoprecipitation': [2430], '"Experimental': [2434], 'Procedures")': [2435], 'employed.': [2437], 'analysis;': [2451], 'several': [2452, 3064], '1E),': [2464], 'consistent': [2470, 3298, 3601, 4323], 'our': [2472, 4763], 'previous': [2473, 2954, 3604], 'report': [2474, 3605], 'largest': [2495, 2717], 'peak': [2496, 2768, 3149, 3167], 'wtAPP': [2498, 2514, 2667, 3026, 3244], 'represented': [2502], '50–99.': [2504, 2721], 'Notably,': [2505], 'whereas': [2506, 2844, 3166, 3928], 'signal': [2512, 2522, 2718], 'membranes,': [2517, 2715, 2727, 2766, 3046, 3247, 3694, 3723], 'became': [2519], 'membranes.': [2529, 3720, 4016, 4457], 'raises': [2531, 4644], 'possibility': [2533, 4776], 'extent': [2536, 3904, 3913, 3964, 4364, 4392], 'related': [2541, 2554, 3467, 4051], 'production,': [2547], 'production.Table': [2560], 'IQuantification': [2561], '50–99Cell': [2569], 'LinesMolecular': [2570], 'speciesYieldProportionsSolubleMembrane-boundTotalSolubleMembrane-boundTotalpmol%%%wtAPPCTFγ': [2571], '50-994.402.366.7770.4': [2572], '±': [2573, 2576, 2580, 2583, 2586, 2589, 2594, 2597, 2601, 2604, 3413, 3417, 3422, 3426, 3890, 3926], '4.374.971.3CTFγ': [2574], '49-992.190.692.8929.6': [2575], '4.325.128.7mtAPP': [2577], '(V717F)CTFγ': [2578], '50-991.131.552.6821.9': [2579], '4.134.827.8CTFγ': [2581], '49-994.452.917.3678.1': [2582], '4.165.272.2wtPS2CTFγ': [2584], '50-998.781.209.9881.5': [2585], '3.772.380.7CTFγ': [2587], '49-991.470.391.8618.5': [2588], '3.727.719.3wtPS2': [2590], '+': [2591], 'DFK-167CTFγ': [2592], '50-994.291.235.52*74.8': [2593], '0.972.874.6CTFγ': [2595], '49-991.370.481.85*25.2': [2596], '0.927.225.4mtPS2': [2598], '(N141I)CTFγ': [2599], '50-992.101.033.1343.0': [2600], '2.864.849.7CTFγ': [2602], '49-992.480.533.0157.0': [2603], '2.835.250.3': [2605], 'Open': [2606], 'table': [2607], 'new': [2610], 'tab': [2611], 'mtPS1—To': [2626], 'confirm': [2628, 4062], 'such': [2629, 3822, 4782], 'mtPS1': [2643, 2680, 2726, 3484, 3518, 3540, 3581, 3596, 3781], '(M146L,': [2644], 'G384A)-overexpressing': [2647], 'cells.': [2648, 2835, 2870, 3509], 'By': [2649], 'incubation': [2650], '20': [2652], 'min,': [2653], 'wtPS1': [2654, 2714, 2781, 3550], 'predominantly,': [2658], 'situation': [2660], 'On': [2676, 2899, 3568, 3701], 'hand,': [2679, 2902, 3571, 3704], 'ratios': [2689], 'differed': [2694], '2A).': [2698, 2793], 'Concomitantly': [2699], '2C).': [2711, 2761], 'significantly': [2737, 2861, 2938, 3406, 3578, 4012], 'larger.': [2738], 'M233T': [2740], '2A),': [2751], 'M146L': [2765], 'almost': [2773, 3554], 'same': [2776, 3556], 'level': [2777], '2C),': [2783], 'slightly': [2790, 4027], 'mt': [2799], 'Show': [2801], '—To': [2810], 'determine': [2811], 'differences': [2814], 'due': [2816], 'idiosyncrasy': [2819], 'APP-overexpressing': [2833, 2869], 'Fig.': [2839, 2926, 3105, 3131, 3147, 3252], '3,': [2840], 'B,': [2843], 'V717G': [2866], 'similarly': [2880, 3695], 'analyzed': [2881, 3675], 'spectrometry.': [2884, 3684], '3C).': [2898, 4007], 'V717G-': [2910], 'V717F-overexpressing': [2912], 'mtAPP-expressing': [2922], '1E).': [2927], 'Interestingly,': [2928, 3634], 'lines': [2931, 3101], 'appeared': [2935], 'produce': [2937], '52–99': [2943, 4005, 4010, 4022, 4047], 'compared': [2945, 3587, 3734, 3767], 'observation': [2950], 'agrees': [2952], 'reports': [2955, 4069], '(14Yu': [2956], '24Chen': [2977], 'Gu': [2979, 4102, 4263, 4397], 'Hasegawa': [2981, 4104, 4265, 4399], 'Ruan': [2983, 4106, 4267, 4401], 'X.': [2984, 4107, 4227, 4268, 4292, 4402], 'Westaway': [2989, 4112, 4273, 4407], 'Mount': [2991, 4114, 4275, 4409], '36521-36526Google': [3001, 4124, 4285, 4419], 'From': [3003], 'results,': [3005], 'likely': [3008], 'variability': [3015], 'lines,': [3018], 'wtPS1/2': [3028], 'increased.': [3052], 'Quantification': [3053], 'Species': [3056], 'Sequencer—Peak': [3061], 'heights': [3062], 'profiles': [3070], 'quantitative.': [3074], 'sought': [3077], 'quantify': [3079], 'precisely': [3080], 'molecular': [3082, 3153, 3171], 'amino': [3089, 3136], 'four': [3099, 3152], 'carefully': [3108], 'analyzed.': [3109], 'C4-immunoprecipitated': [3110], 'fractionated': [3113], 'filtration,': [3116], 'RP-HPLC': [3119], '4A).': [3121], '4A)': [3132], 'sequence': [3138, 3217], 'analysis.': [3139, 3218], 'Five': [3140], '1E);': [3148], 'contained': [3151, 3169], '(CTFγ': [3155, 3173, 3196], '52–99,': [3156, 3197], '51–99,': [3157, 3198], '49–99),': [3165], '48–99).': [3176], 'Among': [3177], 'them,': [3178], 'accounted': [3183], '>90%': [3185], 'line,': [3191], '48–99)': [3200], 'detectable': [3203], 'levels.': [3206], 'Other': [3207], '(e.g.': [3209, 3868, 3888], '53–99,': [3211], '54–99,': [3212], 'etc.)': [3213], 'undetectable': [3215], 'accurate': [3220], '49–99/50–99': [3224], 'provided': [3230], 'proportions': [3235, 3264, 3388], '28.7': [3240], '19.3%': [3242], 'respectively': [3248, 3476], '(Table': [3249, 3385, 4353], '4B).': [3253, 3456], '72.2': [3271], '50.3%': [3273], 'respectively,': [3284, 3428], 'data': [3296, 4328], 'analysis,': [3305], 'indicating': [3306], 'evaluation': [3309], 'informative': [3315], 'present': [3318, 4326], 'study.': [3319], 'Proportion': [3320], 'Decreased': [3325], 'Low': [3328], 'Concentration': [3329], 'DFK-167—To': [3331], 'verify': [3333], 'independent': [3344], 'type,': [3348], 'next': [3350, 3674], 'effect': [3353, 3522, 3592, 3785, 3856], 'DFK-167,': [3355], '1D),': [3374], 'μm': [3401, 3954], 'inhibitor-treated': [3402], '(p': [3407], '<': [3408], '0.05)': [3409], 'changed': [3410], '74.8': [3412], '0.9%': [3414, 3423], '81.5': [3416], '3.7%': [3418], '25.2': [3421], '18.5': [3425], '3.7%,': [3427], 'concomitantly': [3429], 'decreasing': [3436], '∼60%': [3438], 'more': [3440, 3881, 3965], 'than': [3441, 3451, 3882, 3966, 4670], '80%': [3442], 'increasing': [3446], '∼40%': [3448], 'less': [3450], '20%': [3452], '(Figs.': [3453, 3738, 4037], '1D': [3454], '4C).': [3478, 4434], 'Additive': [3479], 'Effects': [3480], 'Species—An': [3489], 'accompanying': [3495], 'mtAPP-,': [3505], 'mtPS1-,': [3506], 'mtPS2-overexpressing': [3508], 'To': [3510], 'examine': [3511], 'combination': [3514], 'additional': [3521], 'established': [3529], 'transfectants': [3531], 'co-expressing': [3532], '(V717F;': [3534], 'hereafter': [3535], 'VF)': [3536], '(M233T': [3541], 'G384A).': [3543], 'ratio': [3545], '(VF/wtPS1)': [3552], 'V717F-only': [3561], '5,': [3564, 3652], '(VF/M233T': [3583], 'VF/G384A)': [3585], 'VF/wtPS1.': [3589], 'additive': [3591, 3784], '(25Citron': [3606], 'Eckman': [3608], 'C.B.': [3609], 'Corcoran': [3612], 'George': [3621], 'Hyslop': [3622], 'Younkin': [3624], 'S.G.': [3625], 'Neurobiol.': [3628], 'Dis.': [3629], '5:': [3631], '107-116Google': [3632], 'VF/G384A': [3638, 3719], 'smaller': [3642, 3714, 3732], 'CTFα/β': [3650], 'possible': [3658, 4681, 4795], 'mtPS1-associated': [3661], 'lower': [3665], 'affinity': [3666], 'and/or': [3667], 'inefficient': [3668], 'substrate.': [3672], 'VF/wtPS1': [3693], '5C).': [3700, 3741, 4041], 'VF/M233T': [3717], 'mtPS1-only': [3736], '2C': [3739], 'Because': [3742], 'analyses': [3745], 'so': [3748, 4804], 'quantitative,': [3749], 'could': [3751], 'accurately': [3753], 'assess': [3754], 'VF/wt-PS1': [3771], 'membrane.': [3772], 'long': [3792, 3877, 3915, 4381, 4712], 'been': [3793], 'claimed': [3794], 'clustered': [3799], 'close': [3800], 'terminus': [3804], 'alter': [3807], 'leading': [3813], 'production.': [3817, 3917], 'Accordingly,': [3818], 'thought': [3820], 'would': [3825], 'preferentially': [3826], 'affect': [3827, 4390, 4659], 'without': [3829], 'substantial': [3830], 'effects': [3831], 'boundary.': [3840], 'most': [3842], 'unexpectedly,': [3843], 'Figs.': [3847], '1E': [3848], '3C,': [3850, 4432], 'had': [3853], 'remarkable': [3855], '72.2%).': [3869], 'far': [3880, 4475], '39.5': [3889], '0.98%': [3891], 'case,': [3902], 'proportionate': [3910], 'example,': [3919], '(81.6': [3925], '2.1%),': [3927], '50.3%,': [3935], 'can': [3939], 'seen': [3941], '2).': [3948], 'presence': [3951], 'about': [3961], '2-fold,': [3962], '(∼1.3-fold).': [3971], 'does': [3979, 4388, 4656], 'faithfully': [3981], 'reflect': [3982], '49–99.': [3988], 'contrast': [3990], 'significant': [3999], 'another': [4002], 'Moreover,': [4008], 'Even': [4017], 'appears': [4023], '1E,': [4038, 4431], '2C,': [4039], 'study': [4058], 'required': [4060], 'view.': [4064], 'number': [4066], 'argued': [4071], 'reciprocal': [4074], 'cleavage.': [4082, 4854], 'Several': [4083], 'reduce': [4095], '(24Chen': [4100, 4261, 4395], '26Levitan': [4126], 'Doyle': [4128], 'T.G.': [4129, 4736], 'Brousseau': [4130], 'Lee': [4132], 'M.K.': [4133], 'Thinakaran': [4134], 'Slunt': [4136], 'H.H.': [4137], 'Greenwald': [4140], 'Proc.': [4142, 4211, 4244, 4309], 'Natl.': [4143, 4212, 4245, 4310], 'Acad.': [4144, 4213, 4246, 4311], 'Sci.': [4145, 4214, 4247, 4312], 'U.': [4146, 4215, 4248, 4313], '1996;': [4149], '93:': [4150], '14940-14944Google': [4151], '27Zhang': [4153], 'NeuroReport.': [4188], '11:': [4190], '3227-3230Google': [4191], '28Kulic': [4193], 'Walter': [4195, 4578], 'Baumeister': [4201], 'Romig': [4203], '97:': [4219], '5913-5918Google': [4220], '29Moehlmann': [4222, 4287], 'Murrell': [4230, 4295], 'Kaether': [4234, 4299, 4570], 'Zheng': [4236, 4301], 'Ghetti': [4238, 4303], '99:': [4252, 4317], '8025-8030Google': [4253, 4318], 'quantitative': [4327], 'based': [4329], 'sequencing,': [4331], 'showing': [4332], 'reduced': [4345], '∼50%': [4347], 'those': [4349], 'causes': [4357], 'reduction': [4361], 'alteration': [4370], '(i.e.': [4377], 'CTFγ).': [4382], 'contrasts': [4384], 'mtAPP,': [4386], 'produces': [4422], 'unexpectedly': [4424], 'speculate': [4440], 'characteristic': [4444], 'underlies': [4445], 'differing': [4459], 'characteristics': [4460], 'might': [4465, 4831], 'complicate': [4467], 'γ-': [4471, 4649, 4797, 4828], 'ϵ-cleavage.': [4473], 'Thus': [4474], 'boundary,': [4488], '30Okamoto': [4511], 'Kawano': [4513], 'Murakami': [4515], 'Sasayama': [4517], 'Araki': [4519], 'Miki': [4521], 'Wong': [4523], 'A.J.': [4524], 'Saya': [4525], 'Cell': [4528], '155:': [4531], '755-762Google': [4532], '31Marambaud': [4534], 'Shioi': [4536], 'Serban': [4538], 'Georgakopoulos': [4540], 'Sarner': [4542], 'Nagy': [4544], 'V.': [4545], 'Baki': [4546], 'Wen': [4548], 'Efthimiopoulos': [4550], 'Shao': [4552], 'Z.': [4553], 'Wisniewski': [4554], 'Robakis': [4556], 'N.K.': [4557], '21:': [4561, 4614], '1948-1956Google': [4562], '32Lammich': [4564], 'Okochi': [4566], 'Takeda': [4568, 4607], 'Zimmer': [4574], 'A.K.': [4575], '44754-44759Google': [4589], '33Okochi': [4591], 'Fukumori': [4595], 'Tanii': [4597], 'Tomita': [4599], 'Tanaka': [4601], 'Iwatsubo': [4603], 'Kudo': [4605], '5408-5416Google': [4615], 'suggests': [4618], 'universal': [4624], 'phenomena': [4625], 'subset': [4629], 'proteins.': [4634], 'Further,': [4635], 'questions.': [4646], 'Which': [4647], 'cleavage,': [4648], 'comes': [4652], 'first,': [4653], 'other?': [4661], 'failed': [4663], 'detect': [4665], '48–99': [4672], 'either': [4674], 'sequencing.': [4679], 'interpretation': [4682], 'CTFβ': [4685, 4807], 'ϵ-site,': [4691], 'thus': [4693], 'products': [4695], '(Aβ': [4696], '1–48': [4697], '1–49)': [4699], 'undergo': [4700], 'γ-cleavage,': [4701], 'Previous': [4706], 'existence': [4710], '1–46': [4714], '(34Kuo': [4719], 'Y.M.': [4720], 'Kokjohn': [4721], 'T.A.': [4722], 'Watson': [4723], 'M.D.': [4724], 'Woods': [4725], 'A.S.': [4726], 'Cotter': [4727], 'R.J.': [4728], 'Sue': [4729], 'L.I.': [4730], 'Kalback': [4731], 'W.M.': [4732], 'Emmerling': [4733], 'M.R.': [4734], 'Beach': [4735], 'Roher': [4737], 'A.E.': [4738], 'Am.': [4739], 'Pathol.': [4741], '156:': [4743], '797-805Google': [4744], '35Kamal': [4746], 'Almenar-Queralt': [4748], 'LeBlanc': [4750], 'J.F.': [4751], 'Roberts': [4752], 'Goldstein': [4754], '414:': [4758], '643-648Google': [4759], 'hands,': [4764], 'undetectable,': [4769], 'cannot': [4772], 'rule': [4773], 'out': [4774], 'steady-state': [4779], 'levels': [4780], 'intermediates': [4783], 'lysates': [4786], 'below': [4788], 'detection': [4790], 'limit.': [4791], 'occur': [4800], 'simultaneously': [4801], 'nearly': [4803], 'along': [4805], 'molecule,': [4808], 'leaving': [4809], 'small': [4811], 'hydrophobic': [4812], 'peptide': [4814], 'must': [4816], 'difficult': [4818], 'isolate': [4820], 'detect.': [4822], 'Development': [4823], 'inhibitors': [4826], 'help': [4832], 'us': [4833, 4842], 'identify': [4835], 'intermediate(s)': [4838], 'lead': [4841], 'better': [4845], 'understanding': [4846], 'kinds': [4852]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2118330889', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-31T02:28:17.533049', 'created_date': '2016-06-24'}