Abstract: Abstract. The transfer of diazepam and N ‐demethyldiazepam across the placenta in early human pregnancy is studied in a group of 12 patients after a single dose, and in a group of 7 patients after the continued use of diazepam for up to a month. After a single dose the feto‐maternal ratio of the diazepam concentrations is 1.2, while after continued use it is 0.4. The main reason for this difference is probably the incomplete distribution of diazepam after a single dose at the time the samples are taken. The transfer of N ‐demethyl‐diazepam across the placenta occurs just as easily and the feto‐maternal ratio after continued treatment is 0.4, too. The concentration of N ‐demethyldiazepam in the fetal liver is higher than any other concentration measured and this could constitute indirect evidence of metabolism in the fetal liver. The concentrations of diazepam and N ‐demethyldiazepam in fetal tissues are at a level comparable to the concentration of diazepam that has a damaging effect on cells in cellular cultures.
Publication Year: 1974
Publication Date: 1974-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 38
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