Publication Information

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'https://openalex.org/W2355809241', 'https://openalex.org/W2133034461', 'https://openalex.org/W2057250838', 'https://openalex.org/W2036798259', 'https://openalex.org/W2005920859'], 'abstract_inverted_index': {'Epidermal': [0, 299, 598], 'growth': [1, 40, 48, 300, 339, 347, 599, 608, 650, 657, 699, 743, 755, 760, 779, 871, 931, 1216], 'factor': [2, 301, 600, 744, 780, 1217], 'receptor': [3, 302, 884, 1557], '(EGFR)': [4, 303, 885], 'ligands': [5, 304, 968, 1203, 1558, 3357, 3531], 'are': [6, 113, 305, 412, 933, 940, 969, 992, 1129, 1421, 2983, 3760], 'synthesized': [7, 306, 994, 3883], 'as': [8, 76, 78, 97, 176, 192, 194, 228, 307, 375, 377, 396, 475, 491, 493, 527, 935, 995, 998, 1262, 1556, 1852, 1869, 2307, 2450, 2652, 2672, 3478, 3480, 3534, 3853, 3855, 4030, 4065, 4084, 4234], 'type': [9, 308, 1133, 2646, 3321], 'I': [10, 309, 1134, 3793], 'membrane': [11, 310, 1135, 1553, 2247, 2460, 2745], 'protein': [12, 195, 311, 494, 645, 694, 961, 1709, 3798, 3816, 3836, 4277], 'precursors': [13, 53, 312, 352, 938, 1002], 'exposed': [14, 313, 1003, 3427], 'at': [15, 106, 136, 314, 405, 435, 1004, 2262, 3428, 4158, 4178, 4185, 4195, 4367], 'the': [16, 21, 27, 31, 43, 107, 117, 123, 130, 137, 222, 238, 242, 251, 275, 279, 315, 320, 326, 330, 342, 406, 416, 422, 429, 436, 521, 537, 541, 550, 574, 578, 874, 878, 882, 948, 955, 1005, 1009, 1013, 1122, 1138, 1143, 1149, 1154, 1158, 1205, 1208, 1211, 1398, 1403, 1418, 1446, 1465, 1692, 1696, 1703, 1706, 1712, 1725, 1733, 1863, 2113, 2129, 2137, 2148, 2152, 2230, 2235, 2244, 2249, 2265, 2439, 2458, 2580, 2587, 2594, 2598, 2606, 2612, 2614, 2622, 2642, 2732, 2844, 3202, 3285, 3292, 3347, 3352, 3369, 3414, 3429, 3442, 3482, 3502, 3512, 3516, 3527, 3746, 4068, 4074, 4142, 4171, 4204, 4237, 4250, 4273, 4300, 4306, 4330, 4353, 4357, 4368, 4371, 4380], 'cell': [17, 80, 108, 111, 138, 247, 257, 316, 379, 407, 410, 437, 546, 556, 740, 1006, 1433, 1713, 1715, 3165, 3327, 3430, 3485], 'surface.': [18, 109, 139, 317, 408, 438, 1007], 'Shedding': [19, 318], 'of': [20, 23, 38, 46, 59, 120, 129, 155, 224, 250, 253, 281, 319, 322, 337, 345, 358, 419, 428, 454, 523, 549, 552, 580, 751, 754, 947, 1011, 1140, 1177, 1201, 1210, 1255, 1411, 1432, 1448, 1468, 1552, 1695, 1705, 1724, 1728, 1849, 1865, 2144, 2151, 2232, 2243, 2267, 2461, 2466, 2469, 2560, 2597, 2611, 2644, 2647, 2731, 2736, 2747, 2836, 2978, 3263, 3349, 3351, 3354, 3371, 3474, 3481, 3504, 3529, 3748, 3766, 4020, 4073, 4168, 4212, 4255, 4275, 4278, 4356, 4370, 4384], 'ectodomain': [22, 119, 219, 283, 321, 418, 518, 582, 1437, 1569, 2615, 3440, 3448, 3494], 'these': [24, 39, 93, 323, 338, 392, 2865, 3276], 'proteins': [25, 324, 1449, 1554, 3373], 'is': [26, 134, 159, 325, 433, 458, 701, 745, 1391, 1439, 2132, 2255, 2850, 2967, 2972, 3167, 3426, 3511], 'way': [28, 327], 'cells': [29, 94, 149, 166, 328, 393, 448, 465, 1444, 2866, 3199, 3243, 3362, 3899, 4247], 'regulate': [30, 329, 1445], 'equilibrium': [32, 331], 'between': [33, 332], 'cell-associated': [34, 333], 'and': [35, 51, 72, 147, 182, 213, 234, 236, 255, 262, 284, 334, 350, 371, 446, 481, 512, 533, 535, 554, 561, 583, 711, 848, 886, 897, 960, 1019, 1030, 1161, 1171, 1266, 1566, 1737, 1856, 2046, 2118, 2135, 2139, 2258, 2419, 2447, 2542, 2719, 2792, 2821, 2926, 2928, 2932, 2934, 2981, 3218, 3270, 3322, 3325, 3360, 3466, 3491, 3537, 3805, 3815, 3827, 3839, 3851, 3868, 3878, 3895, 3906, 3922, 3949, 3951, 3983, 4009, 4018, 4061, 4188, 4241, 4264, 4315, 4344, 4363], 'diffusible': [36, 335, 707, 2140], 'forms': [37, 336, 1460], 'factors.': [41, 340], 'Whereas': [42, 341], 'regulated': [44, 161, 343, 460, 2153, 2257, 2984, 3162, 3492, 3755], 'shedding': [45, 62, 158, 220, 244, 344, 361, 457, 519, 543, 1570, 1868, 2966, 3163, 3296, 3309, 3370, 3449, 3495, 3498, 3532, 3747, 3752], 'transforming': [47, 346, 649, 698, 759], 'factor-α,': [49, 348], 'HB-EGF,': [50, 349, 2980, 3536], 'amphiregulin': [52, 351, 807, 2047, 2982, 3538], 'have': [54, 353, 3363, 3418], 'been': [55, 65, 354, 364, 1870, 2628, 3342, 3365, 3419], 'clearly': [56, 66, 143, 355, 365, 442, 964, 1424, 2974, 3170], 'established,': [57, 356], 'regulation': [58, 357, 1864, 3350, 3528], 'full-length': [60, 359, 2584, 2871, 3203, 3333], 'pro-EGF': [61, 87, 121, 261, 282, 360, 386, 420, 560, 581, 2116, 2820, 2916, 3205, 3250, 3295, 3308, 3315, 3335, 3425, 3493, 3749, 3751, 4081], 'has': [63, 362, 2626, 3341, 3522], 'not': [64, 185, 273, 363, 484, 572, 993, 1423, 2133, 3168, 3742, 3754], 'demonstrated.': [67, 366], 'Here,': [68, 367], 'using': [69, 368, 4058, 4141, 4266, 4289, 4333], 'both': [70, 369, 2748, 3267, 4261, 4361], 'wild-type': [71, 164, 370, 463], 'M2': [73, 372, 3323], 'mutant': [74, 246, 373, 545, 3484], 'CHO-K1': [75, 374, 3318, 3338], 'well': [77, 193, 376, 492, 3479, 3854], 'HeLa': [79, 148, 256, 378, 447, 555, 3326, 3361, 3757], 'lines': [81, 112, 258, 380, 411, 557, 3328], 'transiently': [82, 381, 3329], 'transfected': [83, 382, 2867, 3200, 3245, 3330], 'with': [84, 232, 241, 383, 531, 540, 1110, 1464, 2248, 2457, 2819, 2853, 2861, 2869, 3197, 3201, 3212, 3241, 3246, 3257, 3266, 3298, 3331, 4170, 4208, 4360], 'epitope-tagged': [85, 384], 'rat': [86, 385, 1020, 1141, 3334, 4080, 4302], 'expression': [88, 297, 387, 596, 3888, 3981, 4232, 4320], 'plasmid,': [89, 388], 'we': [90, 142, 389, 441, 3311, 3417], 'demonstrate': [91, 390, 3422], 'that': [92, 145, 268, 285, 391, 444, 567, 584, 757, 893, 939, 966, 1152, 1388, 1429, 1701, 1731, 2564, 2817, 2976, 2986, 3280, 3287, 3423, 3487, 3497, 3739], 'synthesize': [95, 394], 'EGF': [96, 395, 611, 660, 883, 1155, 1256, 1389, 1416, 2145, 2233, 2444, 2448, 2565, 2634, 2824, 2918, 3210, 3264], 'a': [98, 160, 225, 294, 397, 459, 524, 593, 702, 752, 1166, 1172, 2813, 2834, 2870, 3247, 3261, 3271, 3332, 3461, 3505, 4121, 4334], 'high': [99, 398, 1404, 2452, 3764, 4144, 4279], 'molecular': [100, 399, 1113, 1405, 1413, 1455, 2453, 2471, 3799, 4280], 'weight': [101, 400, 1406, 1414, 2454, 3800, 4281], 'membrane-associated': [102, 401, 1001, 2827], 'precursor': [103, 131, 402, 430, 973, 1025, 1127, 1407, 1708, 2130, 2455, 2585, 2640], 'glycoprotein': [104, 403], 'expressed': [105, 404, 1450], 'All': [110, 409], 'able': [114, 413, 3420], 'to': [115, 204, 259, 290, 414, 503, 558, 589, 737, 748, 876, 1118, 1131, 1215, 1409, 1461, 1719, 2475, 2593, 2603, 2605, 2617, 2833, 2841, 2843, 2922, 2936, 3208, 3254, 3304, 3313, 3345, 3367, 3421, 3436, 3762, 4055, 4079, 4117, 4130, 4165, 4249, 4271, 4341], 'release': [116, 152, 415, 451, 2231, 2596, 2919, 3265, 3437], 'entire': [118, 417, 2599, 3439, 4307], 'in': [122, 163, 278, 421, 462, 577, 944, 954, 1157, 1207, 1257, 1862, 2147, 2234, 2478, 2579, 2621, 2631, 2851, 2856, 3284, 3317, 3441, 3526, 3745, 3756, 4203, 4286], 'extracellular': [124, 423, 956, 1150, 2623, 3443], 'medium': [125, 424, 3971], 'following': [126, 425, 4172], 'juxtamembrane': [127, 426, 1159, 2581], 'cleavage': [128, 427, 1431, 2578], 'once': [132, 431, 3424], 'it': [133, 168, 432, 467, 2838, 3278, 3432], 'present': [135, 434, 3415], 'More': [140, 439, 3509], 'significantly': [141, 440], 'established': [144, 443, 2975], 'CHO-M2': [146, 243, 445, 542, 3483], 'only': [150, 449, 2136], 'constitutively': [151, 450], 'low': [153, 452], 'levels': [154, 453], 'pro-EGF.': [156, 455], 'This': [157, 456, 742, 2253, 2574, 2847, 4373], 'phenomenon': [162, 461, 2254], 'CHO': [165, 254, 464, 553], 'where': [167, 466], 'can': [169, 468, 2566, 2987, 3288, 3433, 3450], 'be': [170, 205, 274, 291, 469, 504, 573, 590, 749, 1132, 1720, 2260, 2567, 2618, 2636, 2988, 3289, 3434, 3451, 3743], 'induced': [171, 470], 'by': [172, 186, 230, 237, 471, 485, 529, 536, 717, 942, 1722, 2990, 3453, 3884, 4067, 4086, 4200, 4236, 4260, 4285, 4328, 4378], 'different': [173, 472, 2561, 2645], 'agents': [174, 473], 'such': [175, 474, 1261, 1555, 1851, 2306, 2651, 2671, 3533], 'phorbol': [177, 476, 637, 686], '12-myristate': [178, 477, 638, 687], '13-acetate': [179, 478], '(PMA),': [180, 479], 'pervanadate,': [181, 480], 'serum': [183, 214, 482, 513, 627, 676, 2999, 3213, 3465, 3965], 'but': [184, 483, 997, 3259, 4207], 'calcium': [187, 486, 2995, 3268], 'ionophores.': [188, 487], 'Using': [189, 488], 'specific': [190, 489, 3475], 'inhibitors': [191, 490, 2924, 2938, 3477], 'kinase': [196, 495, 646, 695, 891], 'C': [197, 496], '(PKC)': [198, 497], 'depletion,': [199, 498], 'PMA': [200, 499, 2991, 3215, 3258, 3458], 'stimulation': [201, 215, 265, 500, 514, 564, 3262], 'was': [202, 501, 2445, 2586, 2839, 2920, 3499, 3753, 3846, 3936, 3992, 3998, 4006, 4076, 4139, 4162, 4222, 4225, 4258, 4282, 4312, 4326, 4350, 4375], 'shown': [203, 502, 2629, 2840], 'completely': [206, 505], 'dependent': [207, 506], 'on': [208, 507, 734, 1451, 2830, 3294], 'PKC': [209, 508, 2993], 'activation': [210, 509, 2266, 3503], 'whereas': [211, 510, 3216, 3464, 3515, 4125], 'pervanadate': [212, 511, 3001, 3467], 'were': [216, 515, 3818, 3831, 3841, 3861, 3872, 3882, 3900, 3912, 3929, 3953, 3987, 4028, 4052], 'not.': [217, 516], 'Regulated': [218, 517], 'involves': [221, 520, 2239], 'activity': [223, 522, 892, 1698, 2816], 'zinc': [226, 525], 'metalloprotease': [227, 526, 2923, 3507, 3518], 'determined': [229, 528], 'inhibition': [231, 530], 'phenantrolin': [233, 532], 'TAPI-2': [235, 534, 3948], 'results': [239, 538, 2854, 3737], 'obtained': [240, 539, 2855, 3819, 3832, 3847, 3873], 'defective': [245, 544], 'line.': [248, 547], 'Comparison': [249, 548], 'ability': [252, 551, 736, 875, 4270], 'shed': [260, 559, 3435], 'pro-TNF-α': [263, 562], 'upon': [264, 563], 'greatly': [266, 565], 'suggests': [267, 566, 1428], 'TACE': [269, 568, 3740, 3945], '(ADAM': [270, 569], '17)': [271, 570], 'may': [272, 571, 2259, 3741], 'ectoprotease': [276, 575], 'involved': [277, 576], 'secretion': [280, 579, 1390, 1410, 2119, 2977, 3211, 3256, 3316, 3353], 'this': [286, 585, 2228, 3447], 'protease,': [287, 586], 'which': [288, 587, 3759, 4224], 'remains': [289, 588], 'identified,': [292, 591], 'shows': [293, 592], 'restricted': [295, 594], 'cellular': [296, 595, 895, 1399, 2251, 3339], 'pattern.': [298, 597], '(EGF)': [601], '1The': [602], 'abbreviations': [603, 652], 'used': [604, 653, 3343, 3366], 'are:': [605, 654], 'EGF,': [606, 655, 1012, 3160], 'epidermal': [607, 656], 'factor;': [609, 658], 'EGFR,': [610, 659], 'receptor;': [612, 661], 'DMEM,': [613, 662], "Dulbecco's": [614, 663, 3968], 'modified': [615, 664, 3969, 4377], "Eagle's": [616, 665, 3970], 'medium;': [617, 666], 'FCS,': [618, 667], 'fetal': [619, 668, 3963], 'calf': [620, 669, 3964], 'serum;': [621, 670], 'PBS,': [622, 671], 'phosphate-buffered': [623, 672], 'saline;': [624, 673], 'BSA,': [625, 674], 'bovine': [626, 675], 'albumin;': [628, 677], 'HA,': [629, 678], 'hemagglutinin;': [630, 679], 'RIA,': [631, 680], 'radioimmunoassay;': [632, 681], 'WT,': [633, 682], 'wild': [634, 683, 3320], 'type;': [635, 684], 'PMA,': [636, 685, 3454, 3809], '13-acetate;': [639, 688], 'CHO,': [640, 689], 'chinese': [641, 690], 'hamster': [642, 691], 'ovary;': [643, 692], 'PKC,': [644, 693], 'C;': [647, 696], 'TGF-α,': [648, 697, 2979, 3535], 'factor-α.1The': [651], 'factor-α.': [700], 'small': [703], '(about': [704], '6': [705, 2141, 2442, 2474], 'kDa)': [706, 2477], 'polypeptide': [708], 'first': [709, 4053, 4163, 4313], 'discovered': [710], 'purified': [712], 'from': [713, 972, 1016, 1116, 1402, 1457, 1711, 2570, 2638, 2825, 3164, 3291, 3820, 3833, 3842, 3848, 3862, 3874, 3901, 3913, 3931, 3937, 3954, 3988, 3993, 3999, 4007, 4011, 4024], 'rodent': [714], 'submaxillary': [715, 2127], 'glands': [716, 2421], 'Cohen': [718, 2274, 2334, 2524, 2656], '(1Cohen': [719], 'S.': [720, 783, 859, 1320, 1658, 1930, 2033, 2206, 2275, 2335, 2525, 2657, 3045, 3595, 3697], 'J.': [721, 796, 838, 976, 1035, 1073, 1272, 1284, 1298, 1348, 1374, 1380, 1473, 1494, 1572, 1593, 1650, 1660, 1661, 1824, 1828, 1830, 1831, 1922, 1932, 1933, 1952, 1956, 1958, 1959, 1998, 2037, 2070, 2096, 2160, 2204, 2214, 2218, 2219, 2312, 2336, 2348, 2372, 2393, 2431, 2481, 2503, 2511, 2526, 2547, 2553, 2658, 2677, 2683, 2695, 2711, 2778, 2798, 2882, 2896, 2899, 2949, 3006, 3027, 3037, 3047, 3048, 3074, 3093, 3094, 3107, 3109, 3110, 3131, 3152, 3185, 3221, 3224, 3404, 3587, 3597, 3598, 3617, 3621, 3623, 3624, 3662, 3701, 3720, 4042], 'Biol.': [722, 798, 1101, 1189, 1662, 1682, 1796, 1812, 1832, 1934, 1960, 1999, 2071, 2097, 2337, 2527, 2659, 2884, 2900, 2951, 3049, 3075, 3095, 3112, 3132, 3187, 3225, 3599, 3625, 3663, 3721, 4099], 'Chem.': [723, 1663, 1833, 1935, 1961, 2000, 2072, 2098, 2338, 2528, 2660, 2901, 3050, 3076, 3096, 3133, 3226, 3600, 3626, 3664, 3722], '1962;': [724], '237:': [725], '1555-1561Abstract': [726], 'Full': [727, 1667, 1669, 1837, 1839, 1939, 1941, 1965, 1967, 2004, 2006, 2076, 2078, 2102, 2104, 2342, 2532, 2534, 2664, 2905, 2907, 3054, 3056, 3080, 3082, 3100, 3137, 3139, 3230, 3232, 3604, 3606, 3630, 3632, 3668, 3670, 3726, 3728], 'Text': [728, 1668, 1670, 1838, 1840, 1940, 1942, 1966, 1968, 2005, 2007, 2077, 2079, 2103, 2105, 2343, 2533, 2535, 2665, 2906, 2908, 3055, 3057, 3081, 3083, 3101, 3138, 3140, 3231, 3233, 3605, 3607, 3631, 3633, 3669, 3671, 3727, 3729], 'PDF': [729, 1671, 1841, 1943, 1969, 2008, 2080, 2106, 2344, 2536, 2666, 2909, 3058, 3084, 3102, 3141, 3234, 3608, 3634, 3672, 3730], 'PubMed': [730, 771, 802, 843, 865, 908, 925, 985, 1050, 1065, 1088, 1105, 1193, 1231, 1248, 1277, 1304, 1366, 1482, 1498, 1545, 1581, 1597, 1644, 1672, 1686, 1786, 1800, 1816, 1842, 1916, 1944, 1970, 2009, 2041, 2081, 2107, 2175, 2198, 2282, 2295, 2327, 2364, 2383, 2414, 2436, 2497, 2537, 2716, 2762, 2787, 2807, 2888, 2910, 2955, 3015, 3031, 3059, 3085, 3103, 3116, 3142, 3156, 3191, 3235, 3387, 3408, 3581, 3609, 3635, 3673, 3705, 3731, 4047, 4103], 'Google': [731, 774, 805, 846, 868, 911, 928, 988, 1053, 1068, 1091, 1108, 1196, 1234, 1251, 1280, 1290, 1307, 1334, 1369, 1385, 1485, 1501, 1548, 1584, 1600, 1647, 1675, 1689, 1789, 1803, 1819, 1845, 1919, 1947, 1973, 2012, 2044, 2084, 2110, 2178, 2201, 2225, 2285, 2298, 2330, 2345, 2367, 2386, 2398, 2417, 2437, 2500, 2516, 2540, 2558, 2667, 2688, 2700, 2717, 2742, 2765, 2790, 2810, 2891, 2913, 2958, 3018, 3034, 3062, 3088, 3104, 3119, 3145, 3157, 3194, 3238, 3390, 3411, 3584, 3612, 3638, 3676, 3708, 3734, 4048, 4106], 'Scholar)': [732, 1109, 1386, 1974, 2541, 2559, 2668, 2718, 2791, 2811, 2892, 2914, 3195, 3239], 'based': [733], 'its': [735, 888, 2451, 2571, 2639, 2826, 2831, 2968, 3161, 3438], 'stimulate': [738, 3209, 3255], 'epithelial': [739, 2462], 'growth.': [741], 'now': [746, 2973], 'known': [747, 3761], 'part': [750, 1176], 'family': [753], 'factors': [756, 872, 932], 'includes': [758, 1153], 'factor-α': [761], '(TGF-α)': [762], '(2Derynck': [763], 'R.': [764, 785, 834, 1096, 1184, 1322, 2021, 2187, 2212, 2352, 2485, 2507, 2770, 3150, 3685, 4094], 'Adv.': [765], 'Cancer': [766], 'Res.': [767, 2194, 2359, 2492], '1992;': [768, 1102, 1190, 2513, 4100], '58:': [769], '27-52Crossref': [770], 'Scopus': [772, 803, 844, 866, 909, 926, 986, 1051, 1066, 1089, 1106, 1194, 1232, 1249, 1278, 1305, 1367, 1483, 1499, 1546, 1582, 1598, 1645, 1673, 1687, 1787, 1801, 1817, 1843, 1917, 1945, 1971, 2010, 2042, 2082, 2108, 2176, 2199, 2283, 2296, 2328, 2365, 2384, 2415, 2498, 2538, 2763, 2788, 2808, 2889, 2911, 2956, 3016, 3032, 3060, 3086, 3117, 3143, 3192, 3236, 3388, 3409, 3582, 3610, 3636, 3674, 3706, 3732, 4104], '(249)': [773], 'Scholar),': [775, 806, 823, 847, 2045, 2399, 2418, 2438, 3735], 'heparin': [776], 'binding': [777], 'EGF-like': [778], '(HB-EGF)': [781], '(3Higashiyama': [782], 'Iwamoto': [784, 2020, 3684], 'Goishi': [786], 'K.': [787, 836, 1324, 1344, 1346, 2025, 2521, 2523, 2879, 2946, 3182, 3400, 3689], 'Raab': [788], 'G.': [789, 828, 901, 1283, 2185, 2189, 2519, 2727, 2776, 3130], 'Tanigushi': [790], 'N.': [791, 1041, 1526, 1625, 1767, 1897, 3562], 'Klagsburn': [792], 'M.': [793, 810, 857, 1037, 1239, 1312, 1981, 2017, 2053, 2774, 3122, 3402, 3645, 3681], 'Mekada': [794], 'E.': [795, 2035, 2753, 3393, 3699], 'Cell': [797, 1100, 1188, 1285, 1681, 1795, 1811, 2193, 2220, 2883, 2950, 3111, 3186, 4098], '1995;': [799, 862, 2529, 3113], '128:': [800, 3114], '929-938Crossref': [801], '(279)': [804], '(AR)': [808], '(4Shoyab': [809], 'Plowman': [811, 2090, 3068, 3714], 'G.D.': [812, 2091, 2796, 3069, 3715], 'McDonald': [813], 'V.L.': [814], 'Bradley': [815], 'J.G.': [816], 'Todaro': [817], 'G.J.': [818], 'Science.': [819, 839, 1046, 1541, 1640, 1782, 1912, 3577, 3916], '1989;': [820, 1228, 1331, 1353, 2411], '269:': [821], '234-238Google': [822], 'betacellulin': [824], '(5Shing': [825], 'Y.': [826, 832, 855, 1310, 1314, 2015, 2027, 2877, 2944, 3180, 3679, 3691], 'Christofori': [827], 'Hanahan': [829], 'D.': [830, 1077, 2164, 2316], 'Ono': [831], 'Sasada': [833], 'Igarashi': [835], 'Folkman': [837], '1993;': [840, 922, 982, 1245, 1479, 1578, 2395, 2697, 3012], '259:': [841, 1383, 2556, 2686], '1604-1607Crossref': [842], '(375)': [845], 'epiregulin': [849], '(6Toyoda': [850], 'H.': [851, 1318, 2019, 2216, 2423, 2425, 2703, 2705, 2724, 3148, 3683, 4034, 4036], 'Komurasaki': [852], 'T.': [853, 1297, 1316, 1342, 2023, 2029, 3687, 3693], 'Ikeda': [854], 'Yoshimoto': [856], 'Morimoto': [858], 'FEBS': [860], 'Lett.': [861], '377:': [863], '403-407Crossref': [864], '(73)': [867], 'Scholar).': [869, 929, 989, 1197, 1252, 1549, 1690, 1846, 2111, 2226, 2299, 2743, 2959, 3158, 3412, 4049], 'These': [870, 1126], 'share': [873], 'bind': [877], 'same': [879, 4205], 'receptor,': [880], 'i.e.': [881, 1436, 2241], 'activate': [887], 'intrinsic': [889], 'tyrosine': [890, 3272], 'induces': [894], 'differentiation': [896], 'mitogenic': [898], 'effects': [899], '(7Carpenter': [900], 'Annu.': [902, 919, 979, 1225, 1242, 1476, 1575, 3009], 'Rev.': [903, 920, 980, 1226, 1243, 1362, 1477, 1576, 3010], 'Biochem.': [904, 921, 981, 1478, 1493, 1577, 1592, 2357, 2490, 3011, 3026], '1987;': [905], '56:': [906], '881-914Crossref': [907], '(1046)': [910], 'Scholar,': [912, 1054, 1069, 1092, 1235, 1281, 1291, 1308, 1335, 1356, 1370, 1486, 1502, 1585, 1601, 1648, 1676, 1790, 1804, 1820, 1920, 1948, 2013, 2085, 2179, 2202, 2286, 2331, 2346, 2368, 2387, 2501, 2517, 2689, 2701, 2766, 3019, 3035, 3063, 3089, 3105, 3120, 3146, 3391, 3585, 3613, 3639, 3677, 3709, 4107], '8Fantl': [913], 'W.J.': [914], 'Jonhson': [915], 'D.E.': [916], 'Williams': [917], 'L.T.': [918], '62:': [923, 983, 1480, 1579, 3013], '453-481Crossref': [924], '(929)': [927], 'Most': [930], 'produced': [934], 'soluble': [936, 996, 1415, 1462, 2823], 'inactive': [937], 'activated': [941], 'proteolysis': [943, 1717], 'vesicular': [945], 'compartments': [946], 'secretory': [949, 1395, 2149, 2155, 2245], 'pathway': [950, 2156, 3463], 'before': [951], 'being': [952], 'released': [953, 2568, 2637, 2822], 'medium.': [957, 2624, 3444], 'Both': [958], 'cDNA': [959, 1014, 3206, 3251, 4016, 4075, 4082, 4161, 4221, 4304, 4359, 4374], 'structure': [962], 'analysis': [963, 1015, 4263], 'indicate': [965], 'EGFR': [967, 1202, 1561, 1866, 2964, 3300, 3356, 3530], 'also': [970, 3252, 3364], 'derived': [971], 'molecules': [974, 1026, 1128], '(9Massagué': [975, 1472, 1571, 3005], 'Pandiella': [977, 1474, 1573, 3007], 'A.': [978, 1056, 1060, 1295, 1475, 1574, 1822, 1950, 2031, 2183, 2772, 3008, 3091, 3395, 3615, 3695], '515-541Crossref': [984, 1481, 1580, 3014], '(600)': [987, 1484, 1583, 3017], 'However,': [990, 1397], 'they': [991], 'nondiffusible,': [999], 'glycosylated': [1000, 1124], 'In': [1008, 1137, 2125, 2227, 2300, 2601, 2864, 3302, 3413, 3445], 'case': [1010, 1139], 'human,': [1017], 'mouse,': [1018], 'species': [1021, 1456, 2562], 'predicted': [1022, 1130], 'very': [1023], 'large': [1024], '(respectively': [1027], '1207,': [1028], '1217,': [1029], '1133': [1031], 'amino': [1032, 1146, 1179], 'acids)': [1033], '(10Scott': [1034], 'Urdea': [1036], 'Sanchez-Pescador': [1038], 'M.Q.R.': [1039], 'Fong': [1040], 'Rutter': [1042], 'M.S.W.J.': [1043], 'Bell': [1044, 1082, 2169, 2209, 2321], 'G.I.': [1045, 1083, 2170, 2210, 2322], '1983;': [1047, 1062, 1274], '221:': [1048], '236-240Crossref': [1049], '(306)': [1052], '11Gray': [1055], 'Thomas': [1057], 'J.D.': [1058], 'Ullrich': [1059], 'Nature.': [1061, 1084, 2171, 2323], '303:': [1063], '722-725Crossref': [1064], '(337)': [1067], '12Rall': [1070], 'L.B.': [1071, 2158, 2310], 'Scott': [1072, 2159, 2311], 'Crawford': [1074, 2161, 2211, 2313], 'J.R.': [1075, 2162, 2314], 'Penshow': [1076, 2163, 2213, 2315], 'Niall': [1078, 2165, 2215, 2317], 'H.D.': [1079, 2166, 2318], 'Coghlan': [1080, 2167, 2319], 'J.P.': [1081, 2168, 2320, 2391, 2693], '1985;': [1085, 1287, 2172, 2222, 2324], '313:': [1086, 2173, 2325], '228-231Crossref': [1087, 2174, 2326], '(441)': [1090, 2177, 2329], '13Saggi': [1093, 4091], 'S.S.J.': [1094, 1182, 4092], 'Safirstein': [1095, 1183, 4093], 'Price': [1097, 1185, 4095], 'P.M.': [1098, 1186, 4096], 'DNA': [1099, 1187, 3869, 4097], '11:': [1103, 1191, 1364, 4101], '481-487Crossref': [1104, 1192, 4102], '(48)': [1107, 1195, 1306, 4105], 'an': [1111, 1393, 1440, 3523, 4134, 4152, 4346], 'apparent': [1112], 'mass': [1114], 'ranging': [1115], '150': [1117], '185': [1119], 'kDa': [1120, 2142, 2443], 'for': [1121, 1872, 2590, 4155, 4175, 4182, 4190, 4215], 'mature': [1123, 2138, 2441, 2608, 2633], 'precursors.': [1125], 'proteins.': [1136], 'pro-EGF,': [1142], '1035': [1144], 'N-terminal': [1145], 'acids': [1147, 1180], 'constitute': [1148], 'domain': [1151], 'sequence': [1156, 4083, 4254, 4309], 'region': [1160], 'eight': [1162], 'additional': [1163], '"EGF-like"': [1164], 'modules,': [1165], '22-amino': [1167], 'acid': [1168], 'transmembrane': [1169], 'domain,': [1170], 'short': [1173], 'C-terminal': [1174], 'intracellular': [1175], '76': [1178], '(13Saggi': [1181], 'The': [1198, 1253, 1847, 2464, 2583, 3337, 3472, 4112, 4253, 4323], 'biological': [1199, 1259, 1470, 2236], 'importance': [1200], 'underscores': [1204], 'interest': [1206], 'study': [1209, 3314, 3368], 'enzymatic': [1212], 'processing': [1213], 'leading': [1214, 1401, 2592, 4248], 'bioavailability': [1218], '(14Fisher': [1219], 'D.A.': [1220, 1358, 2356, 2374, 2489, 2509], 'Salido': [1221, 2349, 2482, 2504], 'A.C.': [1222], 'Barajas': [1223, 2353, 2377, 2486], 'L.': [1224, 1340, 1360, 1652, 1924, 2191, 2208, 2354, 2378, 2487, 3039, 3589], 'Physiol.': [1227, 1244, 1381, 2394, 2432, 2512, 2554, 2684, 2696, 2712, 4043], '51:': [1229], '67-80Crossref': [1230], '(162)': [1233], '15Hammerman': [1236], 'M.R.': [1237], "O'Shea": [1238], 'Miller': [1240], 'S.B.': [1241], '55:': [1246], '305-321Crossref': [1247], '(44)': [1250], 'presence': [1254, 2465], 'external': [1258, 1419], 'fluids': [1260], 'saliva,': [1263], 'urine,': [1264], 'milk,': [1265], 'tears': [1267], '(16Beardmore': [1268], 'J.M.': [1269, 1808], 'Richards': [1270], 'R.C.': [1271], 'Endocrinol.': [1273, 1361, 2410], '96:': [1275, 2381], '287-292Crossref': [1276], '(85)': [1279], '17Carpenter': [1282], 'Sci.': [1286, 1330, 2221], '3:': [1288, 2223, 2412], '1-9Crossref': [1289], '18Tsutsumi': [1292], 'O.': [1293, 1378, 2551, 2681], 'Tsutsumi': [1294], 'Oka': [1296], 'Clin.': [1299], 'Investig.': [1300, 1327], '1988;': [1301], '81:': [1302], '1067-1071Crossref': [1303], '19Ohashi': [1309], 'Mtokura': [1311], 'Kinoshita': [1313, 1319], 'Mano': [1315], 'Watanabe': [1317], 'Manabe': [1321], 'Oshiden': [1323], 'Yanaihara': [1325], 'C.': [1326], 'Ophtalmol.': [1328, 1352], 'Vis.': [1329], '30:': [1332], '1879-1882PubMed': [1333], '20Van': [1336], 'Setten': [1337, 2726], 'G.B.': [1338], 'Viinikka': [1339], 'Tervo': [1341], 'Pesonen': [1343], 'Tarkkanen': [1345], 'Perheentupa': [1347], 'Graefes': [1349], 'Arch.': [1350], 'Exp.': [1351, 2192], '227:': [1354], '82-87Google': [1355], '21Fisher': [1357], 'Lakshmanan': [1359, 2371], '1990;': [1363, 1382, 2339, 2361, 2494, 2555, 2661, 2685], '418-442Crossref': [1365], '(345)': [1368], '22Schaudies': [1371], 'R.P.': [1372, 2389, 2408, 2545, 2675, 2691, 2802], 'Grimes': [1373, 2546, 2676], 'Wray': [1375, 2548, 2678], 'H.G.': [1376, 2549, 2679], 'Koldovsky': [1377, 2550, 2680], 'Am.': [1379, 2392, 2430, 2510, 2552, 2682, 2694, 2710, 4041], '1056-1061PubMed': [1384, 2557, 2687], 'indicates': [1387, 2563], 'mainly': [1392], 'exocrine': [1394, 2154], 'process.': [1396], 'events': [1400], 'molecule': [1408, 2131], 'lower': [1412], 'into': [1417, 3307, 4229, 4244, 4299, 4317], 'fluid': [1420, 2237], 'currently': [1422], 'identified.': [1425], 'Recent': [1426], 'evidence': [1427, 2849], 'proteolytic': [1430, 2577, 2815], 'surface': [1434, 1716, 3166], 'proteins,': [1435], 'shedding,': [1438, 2591], 'important': [1441, 1693, 2961, 3281, 3510, 3524], 'mechanism': [1442, 3348], 'whereby': [1443], 'repertoire': [1447], 'their': [1452, 1458, 1469], 'surface,': [1453, 1714, 3431], 'shifting': [1454], 'membrane-bound': [1459, 2814], 'ones': [1463], 'potential': [1466, 2969], 'modification': [1467], 'properties': [1471], '23Hooper': [1487, 1586, 3020], 'N.M.': [1488, 1587, 3021], 'Karran': [1489, 1588, 3022], 'E.H.': [1490, 1589, 3023], 'Turner': [1491, 1590, 3024], 'A.J.': [1492, 1591, 3025], '1997;': [1495, 1594, 2784, 2885, 2952, 3028, 3188], '321:': [1496, 1595, 3029], '265-279Crossref': [1497, 1596, 3030], '(560)': [1500, 1599, 3033], '24Peschon': [1503, 1602], 'J.J.': [1504, 1603, 1745, 1875, 1987, 2059, 3540, 3651], 'Slack': [1505, 1604, 1746, 1876, 3541], 'J.L.': [1506, 1605, 1747, 1877, 3542], 'Reddy': [1507, 1606, 1748, 1825, 1878, 1953, 3543, 3618], 'P.': [1508, 1607, 1654, 1749, 1826, 1879, 1926, 1954, 2429, 2709, 2780, 3041, 3544, 3591, 3619, 4040], 'Stocking': [1509, 1608, 1750, 1880, 3545], 'K.L.': [1510, 1609, 1751, 1881, 3546], 'Sunnarborg': [1511, 1610, 1752, 1882, 3547], 'S.W.': [1512, 1611, 1753, 1883, 1977, 2049, 3548, 3641], 'Lee': [1513, 1612, 1754, 1884, 1996, 2068, 3549, 3660], 'D.C.': [1514, 1613, 1755, 1885, 1997, 2069, 3550, 3661], 'Russel': [1515, 1614, 1756, 1886, 3551], 'W.E.': [1516, 1615, 1757, 1887, 1983, 2055, 3552, 3647], 'Castner': [1517, 1616, 1758, 1888, 1988, 2060, 3553, 3652], 'B.J.': [1518, 1617, 1759, 1889, 1989, 2061, 3554, 3653], 'Johnson': [1519, 1618, 1760, 1890, 2390, 2692, 3555], 'R.S.': [1520, 1619, 1761, 1891, 3556], 'Fitzner': [1521, 1620, 1762, 1892, 3557], 'J.N.': [1522, 1621, 1763, 1893, 3558], 'Boyce': [1523, 1622, 1764, 1894, 3559], 'R.W.': [1524, 1623, 1765, 1895, 3560], 'Nelson': [1525, 1624, 1766, 1896, 3561], 'Kozloski': [1527, 1626, 1768, 1898, 3563], 'C.J.': [1528, 1538, 1627, 1637, 1769, 1779, 1899, 1909, 3564, 3574], 'Wolfson': [1529, 1628, 1770, 1900, 3565], 'M.F.': [1530, 1629, 1771, 1901, 3566], 'Rauch': [1531, 1630, 1772, 1902, 3567], 'C.T.': [1532, 1631, 1773, 1903, 2404, 3568], 'Cerretti': [1533, 1632, 1774, 1904, 3569], 'D.P.': [1534, 1633, 1775, 1905, 3570], 'Paxton': [1535, 1634, 1776, 1906, 1992, 2064, 3571, 3656], 'R.J.': [1536, 1635, 1777, 1907, 1993, 2065, 2093, 2881, 2948, 3071, 3184, 3572, 3657, 3717], 'March': [1537, 1636, 1778, 1908, 3573], 'Black': [1539, 1638, 1780, 1910, 1994, 2066, 3575, 3658], 'R.A.': [1540, 1639, 1781, 1806, 1911, 1995, 2067, 3576, 3659], '1998;': [1542, 1641, 1783, 1813, 1834, 1913, 1962, 2038, 2099, 2741, 3077, 3134, 3578, 3627, 3702, 3723], '282:': [1543, 1642, 1784, 1914, 3579], '1281-1284Crossref': [1544, 1643, 1785, 1915, 3580], '(1359)': [1547, 1646, 1788, 1918, 3583], 'Several': [1550], 'types': [1551], '(among': [1559], 'them': [1560], 'ligands),': [1562], 'receptors,': [1563], 'cell-adhesion': [1564], 'molecules,': [1565], 'ectoenzymes': [1567], 'undergo': [1568], '25Arribas': [1649, 1921, 3036, 3586], 'Coodly': [1651, 1923, 3038, 3588], 'Vollmer': [1653, 1925, 3040, 3590], 'Kishimoto': [1655, 1927, 3042, 3592], 'T.K.': [1656, 1928, 3043, 3593], 'Rose-John': [1657, 1929, 3044, 3594], 'Massague': [1659, 1931, 3046, 3596], '1996;': [1664, 1936, 3051, 3601, 4044], '271:': [1665, 1937, 3052, 3602], '11376-11382Abstract': [1666, 1938, 3053, 3603], '(359)': [1674, 1946, 3061, 3611], '26Blobel': [1677, 1791], 'C.P.': [1678, 1792], 'Curr.': [1679, 1793, 1809], 'Opinion': [1680, 1794], '2000;': [1683, 1797, 2902, 3227], '12:': [1684, 1798], '606-612Crossref': [1685, 1799], '(224)': [1688, 1802], 'With': [1691], 'exception': [1694], 'β-secretase': [1697], '(an': [1699], 'aspartylprotease)': [1700], 'sheds': [1702], 'prodomain': [1704], 'β-amyloid': [1707], '(β-APP)': [1710], 'appears': [1718, 3279], 'mediated': [1721], 'members': [1723], 'metzincin': [1726], 'superfamily': [1727], 'zinc-dependent': [1729, 3506, 3517], 'proteases': [1730, 1850], 'include': [1732], 'matrix': [1734], 'metalloproteinases': [1735], '(MMPs)': [1736], 'ADAMs': [1738], '(for': [1739], 'A': [1740, 4218], 'Disintegrin': [1741], 'And': [1742], 'Metalloproteinase)': [1743], '(24Peschon': [1744, 1874, 3539], '27Black': [1805], 'White': [1807], 'Opin.': [1810], '10:': [1814], '654-659Crossref': [1815], '(428)': [1818], '28Merlos-Suarez': [1821, 1949, 3614], 'Fernadez-Larrea': [1823, 1951, 3616], 'Baselga': [1827, 1955, 3620], 'Arribas': [1829, 1957, 3622], '273:': [1835, 1963, 2100, 3078, 3135, 3628, 3724], '24955-24962Abstract': [1836, 1964, 3629], '(82)': [1844, 1972, 2890, 2957, 3144, 3193, 3637], 'involvement': [1848], 'ADAM': [1853, 1859, 3519], '9': [1854], '(MDC9/meltrin-γ)': [1855], 'more': [1857, 2123], 'importantly': [1858], '17': [1860, 3520], '(TACE)': [1861, 3521], 'ligand': [1867, 2965], 'proposed': [1871], 'TGF-α': [1873], 'HB-EGF': [1975, 3375], '(29Sunnarborg': [1976, 2048], 'Hinkle': [1978, 2050, 3642], 'C.L.': [1979, 2051, 2087, 3065, 3126, 3643, 3711], 'Stevenson': [1980, 2052, 3644], 'Russell': [1982, 2054, 3646], 'Raska': [1984, 2056, 3648], 'C.S.': [1985, 2057, 3649], 'Peschon': [1986, 2058, 3650], 'Gerhart': [1990, 2062, 3654], 'M.J.': [1991, 2063, 3655], '2002;': [2001, 2073, 3665], '277:': [2002, 2074, 3666], '12838-12845Abstract': [2003, 2075, 3667], '(366)': [2011, 2083, 3675], '30Izumi': [2014, 3678], 'Hirata': [2016, 3680], 'Hasuwa': [2018, 3682], 'Umata': [2022, 3686], 'Miyado': [2024, 3688], 'Tamai': [2026, 3690], 'Kurisaki': [2028, 3692], 'Sehara-Fujisawa': [2030, 3694], 'Ohno': [2032, 3696], 'Mekada.': [2034, 3698], 'EMBO': [2036, 3151, 3403, 3700], '17:': [2039, 3703], '7260-7272Crossref': [2040, 3704], '(474)': [2043, 3707], '31Brown': [2086, 3064, 3710], 'Meise': [2088, 2874, 2941, 3066, 3177, 3712], 'K.S.': [2089, 2875, 2942, 3067, 3178, 3713], 'Coffey': [2092, 2880, 2947, 3070, 3183, 3716], 'Dempsey': [2094, 3072, 3127, 3172, 3718], 'P.J.': [2095, 2873, 2940, 3073, 3128, 3176, 3719], '17258-17268Abstract': [2101, 3079, 3725], '(104)': [2109, 3087, 3733], 'Unfortunately,': [2112], 'information': [2114], 'concerning': [2115, 2963], 'maturation': [2117], 'does': [2120], 'appear': [2121], 'much': [2122], 'controversial.': [2124], 'rodents': [2126], 'glands,': [2128], 'detectable': [2134], 'form': [2143, 2610], 'accumulates': [2146], 'granules': [2150], '(12Rall': [2157, 2309], '32Pasquini': [2180], 'F.': [2181, 2768], 'Petris': [2182], 'Sbaraglia': [2184], 'Scopelliti': [2186], 'Cenci': [2188], 'Frati': [2190], '1974;': [2195, 2279], '86:': [2196], '233-236Crossref': [2197], '(21)': [2200, 2764, 2809], '33Scott': [2203], 'Patterson': [2205], 'Rall': [2207], 'Goghlan': [2217], '19-28Crossref': [2224], 'case,': [2229], '(saliva)': [2238], 'exocytosis,': [2240], 'fusion': [2242], 'granule': [2246], 'apical': [2250, 2459], 'membrane.': [2252], 'highly': [2256], 'achieved': [2261, 3500], 'least': [2263], 'through': [2264, 2576, 2641, 3460, 3469, 3501], 'adrenergic': [2268], 'receptors': [2269], '(34Byyny': [2270], 'R.L.': [2271], 'Orth': [2272], 'D.N.': [2273], 'Doyne': [2276], 'E.S.': [2277], 'Endocrinology.': [2278, 2803], '95:': [2280], '776-782Crossref': [2281], '(322)': [2284], '35Roberts': [2287], 'M.L.': [2288], 'Biochim.': [2289, 2756, 2781], 'Biophys.': [2290, 2358, 2491, 2757, 2782], 'Acta.': [2291, 2758, 2783], '1978;': [2292], '540:': [2293], '246-252Crossref': [2294], '(7)': [2297], 'other': [2301, 3299, 3355], 'tissues': [2302], 'studied': [2303], 'so': [2304, 3169], 'far': [2305], 'kidney': [2308, 2749], '36Breyer': [2332], 'J.A.': [2333, 2655], '265:': [2340, 2662], '16565-16570Abstract': [2341, 2663], '37Lakshmanan': [2347], 'E.C.': [2350, 2370, 2483, 2505], 'Lam': [2351, 2484, 2506], 'Fisher': [2355, 2373, 2488, 2508], 'Commun.': [2360, 2493], '173:': [2362, 2495], '902-911Crossref': [2363, 2496], '(17)': [2366, 2499], '38Salido': [2369], 'Shapiro': [2375], 'L.J.': [2376], 'Histochemistry.': [2379], '1991;': [2380, 2759, 3097], '65-72Crossref': [2382], '(61)': [2385], '39Schaudies': [2388, 2690], '264:': [2396, 2698], 'F523-F531PubMed': [2397, 2699], 'mammary': [2400, 2793, 3242], '(40Brown': [2401], 'C.F.': [2402], 'Teng': [2403], 'Pencost': [2405], 'B.T.': [2406], 'Diaugustine': [2407, 2801], 'Mol.': [2409], '1077-1083Crossref': [2413], '(55)': [2416], 'lacrimal': [2420], '(41Maréchal': [2422], 'Jammes': [2424, 2704, 4035], 'Rossignol': [2426, 2706, 2728, 4037], 'B.': [2427, 2707, 2729, 4038], 'Mauduit': [2428, 2708, 4039], '1999;': [2433, 2713, 3153], '276:': [2434, 2714], 'C734-C746Crossref': [2435, 2715], 'fully': [2440], 'undetectable,': [2446], 'accumulated': [2449], 'associated': [2456], 'cells.': [2463, 2863], 'EGF-containing': [2467], 'peptides': [2468], 'varying': [2470], 'masses': [2472], '(from': [2473], '160': [2476], 'urine': [2479], '(37Lakshmanan': [2480], '42Lakshmanan': [2502], '263:': [2514], 'E142-E150PubMed': [2515], '43Parries': [2518], 'Chen': [2520], 'Misono': [2522], '270:': [2530, 4045], '27954-27960Abstract': [2531], '(31)': [2539], 'milk': [2543], '(22Schaudies': [2544, 2674], '(shed)': [2569], 'membrane-anchored': [2572], 'precursor.': [2573, 2828], 'occurs': [2575], 'region.': [2582], 'major': [2588], 'substrate': [2589], 'initial': [2595, 4153], 'ectodomain.': [2600], 'order': [2602, 3303], 'lead': [2604], 'ultimate,': [2607], '6-kDa': [2609], 'molecule,': [2613], 'needs': [2616], 'further': [2619, 4283, 4376], 'maturated': [2620], 'It': [2625, 2971], 'already': [2627], 'that,': [2630, 3514], 'vitro,': [2632], 'could': [2635], 'action': [2643], 'proteases;': [2648], 'acidic': [2649], 'protease': [2650, 3476], 'pepsin': [2653], '(36Breyer': [2654], 'or': [2669, 2893, 3000, 3214, 3456, 3897], 'serine-proteases': [2670], 'trypsin': [2673, 3772, 3778], '41Maréchal': [2702], 'plasmin': [2720], '(44Mauduit': [2721], 'P': [2722], 'Maréchal': [2723], 'Van': [2725], 'Proceedings': [2730], 'XIII': [2733], 'International': [2734], 'Congress': [2735], 'Eye': [2737], 'Research,': [2738], 'Paris,': [2739], '1998.': [2740], 'Moreover,': [2744], 'fractions': [2746], '(45Jorgensen': [2750], 'P.E.': [2751], 'Nexo': [2752], 'Poulsen': [2754], 'S.S.': [2755], '1074:': [2760], '284-288Crossref': [2761], '46Journe': [2767], 'Wattiez': [2769], 'Piron': [2771], 'Carion': [2773], 'Laurent': [2775], 'Heuson-Stiennon': [2777], 'Falmagne': [2779], '1357:': [2785], '18-30Crossref': [2786], '(11)': [2789], 'gland': [2794], '(47Jahnke': [2795], 'Chao': [2797], 'Walker': [2799], 'M.P.': [2800], '1994;': [2804], '135:': [2805], '2022-2029Crossref': [2806], 'contain': [2812], 'colocalized': [2818], 'Based': [2829], 'sensitivity': [2832], 'set': [2835], 'inhibitors,': [2837], 'belong': [2842], 'serine-protease': [2845], 'family.': [2846], 'experimental': [2848], 'conflict': [2852], 'two': [2857], 'independent': [2858], 'studies': [2859, 3293], 'performed': [2860, 4077, 4140], 'cultured': [2862], 'either': [2868], '(48Dempsey': [2872, 2939, 3175], 'Yoshitake': [2876, 2943, 3179], 'Nishikawa': [2878, 2945, 3181], '138:': [2886, 2953, 3189], '747-758Crossref': [2887, 2954, 3190], 'truncated': [2894], '(49Dong': [2895, 3220], 'Wiley': [2897, 3219, 3222], 'H.S.': [2898, 3223], '275:': [2903, 3228], '557-564Abstract': [2904, 3229], '(64)': [2912, 3237], 'human': [2915, 3204, 3249], 'cDNA,': [2917], 'sensitive': [2921], '(batimastat': [2925], 'BB-2116)': [2927], 'cation': [2929], 'chelators': [2930], '(EDTA': [2931], 'EGTA)': [2933], 'insensitive': [2935], 'non-metalloprotease': [2937], 'Another': [2960], 'feature': [2962], 'regulation.': [2970], 'phenomena': [2985], 'triggered': [2989], '(through': [2992], 'activation),': [2994], 'ionophore': [2996, 3269], '(calcium': [2997], 'influx),': [2998], '(tyrosine': [3002], 'phosphatase': [3003, 3273], 'inhibition)': [3004], '50Pandiella': [3090], 'Massagué': [3092, 3108], '266:': [3098], '5769-5773Abstract': [3099], '51Arribas': [3106], '433-441Crossref': [3115], '(130)': [3118], '52Vecchi': [3121], 'Rudolph-Owen': [3123], 'L.A.': [3124], 'Brown': [3125], 'Carpenter': [3129], '20589-20595Abstract': [3136], '53Fan': [3147], 'Derynck': [3149], '18:': [3154], '6962-6972Crossref': [3155], 'Concerning': [3159], 'established.': [3171], 'et': [3173, 4088], 'al.': [3174, 4089], 'working': [3196, 3240], 'MDCK': [3198], 'failed': [3207, 3253], 'Dong': [3217], '(HB2)': [3244], 'prodomain-truncated': [3248], 'observed': [3260], 'inhibitor.': [3274], 'From': [3275], 'studies,': [3277], 'discrepancies': [3282], 'exist': [3283], 'conclusions': [3286], 'drawn': [3290], 'compared': [3297], 'ligands.': [3301], 'provide': [3305], 'insights': [3306], 'properties,': [3310], 'decided': [3312], '(both': [3319], 'mutant)': [3324], 'cDNA.': [3336, 4372], 'model': [3340], 'previously': [3344, 4032], 'establish': [3346], '(TGF-α,': [3358], 'HB-EGF),': [3359], 'various': [3372], 'including': [3374], '(54Davis-Fleische': [3376], 'K.M.': [3377], 'Brigstock': [3378], 'D.R.': [3379], 'Besner': [3380], 'G.E.': [3381], 'Growth': [3382], 'Factors.': [3383], '2001;': [3384, 3405], '19:': [3385], '127-143Crossref': [3386], '(6)': [3389], '55Nishi': [3392], 'Prat': [3394], 'Hospita': [3396], 'l': [3397], 'V.': [3398], 'Elenius': [3399], 'Klagsbrun': [3401], '20:': [3406], '3342-3350Crossref': [3407], '(110)': [3410], 'study,': [3416], 'CHO-K1,': [3446], 'stimulated': [3452], 'serum,': [3455], 'pervanadate.': [3457], 'acts': [3459], 'PKC-dependent': [3462], 'act': [3468], 'PKC-independent': [3470], 'pathway(s).': [3471], 'use': [3473], 'line': [3486], 'displays': [3488], 'impaired': [3489], 'constitutive': [3490], 'demonstrated': [3496], 'activity.': [3508], 'fact': [3513], 'role': [3525], '29Sunnarborg': [3640], 'our': [3736], 'suggest': [3738], 'relevant': [3744], 'since': [3750], 'cells,': [3758], 'possess': [3763], 'amounts': [3765], 'TACE.': [3767], 'Chemicals—Peroxidase-conjugated': [3768], 'goat': [3769], 'anti-mouse': [3770], 'IgG,': [3771], '(10000': [3773], 'BAEE': [3774], 'units/mg),': [3775], 'extravidin-peroxidase,': [3776], 'soybean': [3777], 'inhibitor': [3779], '(SBTI,': [3780], '1': [3781], 'mg': [3782], 'inhibits': [3783], '10000': [3784], 'units': [3785], 'trypsin),': [3786], 'aprotinin,': [3787], 'pepstatin': [3788], 'A,': [3789], 'E-64,': [3790], 'phenantrolin,': [3791], 'bisindolylmaleimide': [3792], '(BIM': [3794, 3940], 'I),': [3795], 'EDTA,': [3796], 'tunicamycin,': [3797], 'markers,': [3801], 'DMEM': [3802], 'without': [3803], 'methionine': [3804], 'cysteine,': [3806], 'A23187,': [3807], 'ionomycin,': [3808], 'ampicillin,': [3810], 'LB': [3811, 3813], 'broth,': [3812], 'agar,': [3814], 'G-Sepharose': [3817], 'Sigma': [3821], 'Chemical': [3822], 'Co.': [3823], 'QIAquick': [3824], 'Gel': [3825], 'Extraction': [3826], 'PCR': [3828, 3910, 4071, 4146], 'purification': [3829, 3859], 'kits': [3830, 3860], 'Qiagen.': [3834], 'BCA': [3835], 'assay': [3837], 'kit': [3838], 'Sulfo-NHS-LC-Biotin': [3840], 'Perbio.': [3843], 'Triton': [3844], 'X-100': [3845], 'MERCK.': [3849], 'N-': [3850], 'O-deglycosylation': [3852], 'Quantum': [3856], 'Prep': [3857], 'Plasmid': [3858], 'BioRad': [3863], 'Laboratories.': [3864], 'Desoxynucleotide': [3865], 'trisphosphates,': [3866], 'agarose,': [3867], 'size': [3870], 'markers': [3871], 'Amersham': [3875], 'Biosciences.': [3876], 'Upstream': [3877], 'downstream': [3879], 'oligonucleotide': [3880], 'primers': [3881], 'MWG-biotech.': [3885], 'pTargeT™': [3886, 4230], 'mammalian': [3887, 3980, 4231, 4319], 'vector': [3889, 3982, 4233, 4321], 'system,': [3890], 'TnT-coupled': [3891], 'reticulocyte': [3892, 4291], 'lysate': [3893, 4292], 'systems': [3894, 4293], 'JM-109': [3896, 4245], 'DH5α-competent': [3898], 'Promega.': [3902], 'Expand™': [3903, 3907, 4062, 4143], 'Reverse': [3904, 4063], 'Transcriptase': [3905, 4064], 'High': [3908], 'Fidelity': [3909], 'System': [3911], 'Roche': [3914], 'Applied': [3915, 4149], '125I-Na': [3917], '(100': [3918], 'μCi/ml,': [3919], '3.7': [3920], 'MBq/ml)': [3921], 'Renaissance®': [3923], 'Western': [3924], 'blot': [3925], 'Chemiluminescence': [3926], 'Reagent': [3927], 'Plus': [3928], 'purchased': [3930], 'PerkinElmer': [3932], 'Life': [3933], 'Sciences.': [3934], 'TRAN35S-Label': [3935], 'ICN.': [3938], 'Ro-31-8220': [3939], 'IX;': [3941], 'methanesulfonate),': [3942], 'polyclonal': [3943], 'anti-human': [3944], '(AB1)': [3946], 'antibody,': [3947], 'TIMP1': [3950], '3': [3952], 'Calbiochem.': [3955], 'Phosphate-buffered': [3956], 'saline': [3957], '(PBS),': [3958], 'NUT.': [3959], 'MIX.F12(HAM)': [3960], 'Glutamax': [3961], '(HAM-F12),': [3962], '(FCS),': [3966], 'OptiMEM,': [3967], '(DMEM)': [3972], 'Glutamax,': [3973], 'fungizone,': [3974], 'penicillin-streptomycin': [3975], 'solution,': [3976], 'random': [3977, 4059], 'primers,': [3978], 'PcDNA3.1/Myc-His': [3979, 4318], 'monoclonal': [3984], 'anti-Myc': [3985], 'antibody': [3986, 3997, 4005], 'Invitrogen.': [3989], 'Exgen': [3990], '500': [3991], 'Euromedex.': [3994], 'Monoclonal': [3995], 'anti-HA': [3996], 'Covance.': [4000], 'Polyclonal': [4001], 'rabbit': [4002], 'antihuman': [4003], 'TNF-α': [4004, 4010], 'Promocell': [4008], 'PreproTech': [4012], 'Inc.': [4013], 'Rat': [4014], 'Pro-EGF': [4015], 'Cloning': [4017], 'Construction': [4019], 'Epitope-tagged': [4021], 'Pro-EGF—Total': [4022], 'RNAs': [4023, 4051], 'Sprague': [4025], 'Dawley': [4026], 'rats': [4027], 'prepared': [4029], 'described': [4031, 4066, 4235], '(56Maréchal': [4033], 'C1164-C1174Crossref': [4046], 'Kidney': [4050], 'subjected': [4054, 4164], 'reverse': [4056], 'transcription': [4057, 4288], 'priming': [4060], "manufacturer's": [4069, 4238], 'protocol.': [4070], 'amplification': [4072, 4169], 'according': [4078], 'published': [4085], 'Saggi': [4087], '(Ref.': [4090], 'GenBank™': [4108], 'accession': [4109], 'number:': [4110], 'M63585).': [4111], '5′': [4113], 'sense': [4114], 'primer,': [4115, 4128], 'complementary': [4116, 4129, 4340], 'nucleotides': [4118, 4131, 4342], '350–368,': [4119], 'carries': [4120, 4133], 'HindIII': [4122], 'restriction': [4123, 4136, 4262, 4348], 'site': [4124, 4349], '3′': [4126], 'antisense': [4127, 4338], '3881–3900,': [4132], 'EcoRI': [4135], 'site.': [4137], 'Amplification': [4138], 'fidelity': [4145], 'system': [4147], '(Roche': [4148], 'Science).': [4150], 'After': [4151], 'denaturation': [4154, 4174], '2': [4156, 4191], 'min': [4157, 4192], '94': [4159, 4179], '°C,': [4160, 4180, 4187], '10': [4166], 'cycles': [4167, 4202], 'conditions:': [4173], '15': [4176], 's': [4177, 4184, 4194, 4214], 'annealing': [4181], '30': [4183, 4193], '55': [4186], 'extension': [4189, 4209], '68': [4196], '°C': [4197], 'then': [4198], 'followed': [4199], '25': [4201], 'conditions': [4206], 'time': [4210], 'incremented': [4211], '5': [4213], 'each': [4216], 'cycle.': [4217], '3550': [4219], 'bp': [4220], 'obtained,': [4223], 'purified,': [4226], 'A-tailed,': [4227], 'inserted': [4228], 'protocols': [4239], '(Promega)': [4240], 'finally': [4242], 'cloned': [4243, 4301], 'bacterial': [4246], 'pT12': [4251, 4257], 'clone.': [4252], 'clone': [4256], 'confirmed': [4259, 4284], 'sequencing': [4265], 'selected': [4267], 'primers.': [4268], 'Its': [4269], 'drive': [4272], 'synthesis': [4274], 'prepro-EGF': [4276, 4303, 4358], 'vitro': [4287], 'TnT®-coupled': [4290], '(Promega).': [4294], 'To': [4295], 'introduce': [4296], 'epitope': [4297, 4382], 'tags': [4298], 'sequence,': [4305], 'coding': [4308], '(HindIII-EcoRI': [4310], 'fragment)': [4311], 'excised': [4314], 'subcloned': [4316], '(Invitrogen).': [4322], 'prepro-EGF/Myc-His': [4324], 'construct': [4325], 'generated': [4327], 'suppressing': [4329], 'stop': [4331], 'codon': [4332], 'PCR-based': [4335], 'strategy.': [4336], 'An': [4337], 'oligonucleotides': [4339], '3768–3787': [4343], 'carrying': [4345], 'ApaI': [4347], 'used,': [4351], 'allowing': [4352], 'in-frame': [4354], 'ligation': [4355], 'c-Myc': [4362], 'His6': [4364], 'epitopes': [4365], 'sequences': [4366], '3′-end': [4369], 'inserting': [4379], 'HA1': [4381], '(YPYDVPDYA)': [4383], 'influenza': [4385], 'virus': [4386], 'hemagg': [4387]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2117939120', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-14T16:08:30.893917', 'created_date': '2016-06-24'}