Abstract:The role of lipoprotein(a) [Lp(a)] in coronary heart disease (CHD), once considered to be well established, has recently been put into question. For example, in a prospective, nested case-control stud...The role of lipoprotein(a) [Lp(a)] in coronary heart disease (CHD), once considered to be well established, has recently been put into question. For example, in a prospective, nested case-control study of the Helsinki Heart Study participants, Jauhiainen et al<sup>1</sup>found no significant increase in risk of CHD associated with higher levels of Lp(a) among 138 hyperlipidemic men who developed coronary events compared with 130 controls. A similar lack of association between Lp(a) and clinical CHD was reported by Simons et al<sup>2</sup>from a cross-sectional analysis of 1202 men and 1512 women older than 60 years. The skewed and broad distribution of Lp(a) levels, ranging from 1.0 mg/dL (0.03 mmol/L) to 210.0 mg/dL (5.25 mmol/L), was strikingly similar in the two groups. Finally, in a report published recently inThe JOURNALinvolving the prospective Physicians' Health Study, Ridker et al<sup>3</sup>found a "virtually identical" Lp(a) distribution among 296Read More
Publication Year: 1994
Publication Date: 1994-04-06
Language: en
Type: editorial
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 26
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