Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2117532213', 'doi': 'https://doi.org/10.4049/jimmunol.1402303', 'title': 'Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1', 'display_name': 'Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1', 'publication_year': 2015, 'publication_date': '2015-02-15', 'ids': {'openalex': 'https://openalex.org/W2117532213', 'doi': 'https://doi.org/10.4049/jimmunol.1402303', 'mag': '2117532213', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25595774', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4319313'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1402303', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/194/4/1417.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jimmunol.org/content/jimmunol/194/4/1417.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030338603', 'display_name': 'Christine B. Read', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Christine B. Read', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062042970', 'display_name': 'Joseph L. Kuijper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph L. Kuijper', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022576050', 'display_name': 'Siv A. Hjorth', 'orcid': 'https://orcid.org/0000-0002-6470-650X'}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Siv A. Hjorth', 'raw_affiliation_strings': ['Novo Nordisk Research Center, Seattle, WA 98109', '†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': 'Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}, {'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002334737', 'display_name': 'Mark Heipel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark D. Heipel', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086545566', 'display_name': 'Xiaoting Tang', 'orcid': 'https://orcid.org/0000-0001-8971-3119'}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaoting Tang', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035045404', 'display_name': 'Andrew J. Fleetwood', 'orcid': 'https://orcid.org/0000-0002-6803-3533'}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Andrew J. Fleetwood', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083299317', 'display_name': 'Jeffrey L. Dantzler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey L. Dantzler', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024022763', 'display_name': 'S. Grell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Susanne N. Grell', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004688282', 'display_name': 'Jesper Kastrup', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jesper Kastrup', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046131657', 'display_name': 'Camilla Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Camilla Wang', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027818709', 'display_name': 'Cameron Brandt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cameron S. Brandt', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037911986', 'display_name': 'Anker Jón Hansen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Anker J. Hansen', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045217032', 'display_name': 'Nicolai Wagtmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Nicolai R. Wagtmann', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101818464', 'display_name': 'Wenfeng Xu', 'orcid': 'https://orcid.org/0000-0003-0896-4309'}, 'institutions': [{'id': 'https://openalex.org/I4210106615', 'display_name': 'Novo Nordisk (United States)', 'ror': 'https://ror.org/011y67d23', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210106615', 'https://openalex.org/I4210159963']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wenfeng Xu', 'raw_affiliation_strings': ['†Novo Nordisk Research Center, Seattle, WA 98109'], 'affiliations': [{'raw_affiliation_string': '†Novo Nordisk Research Center, Seattle, WA 98109', 'institution_ids': ['https://openalex.org/I4210106615']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001021182', 'display_name': 'Vibeke W. Stennicke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189090001', 'display_name': 'Novo Nordisk (Denmark)', 'ror': 'https://ror.org/0435rc536', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I189090001', 'https://openalex.org/I2801134892', 'https://openalex.org/I4210159963']}], 'countries': ['DK'], 'is_corresponding': True, 'raw_author_name': 'Vibeke W. Stennicke', 'raw_affiliation_strings': ['*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and'], 'affiliations': [{'raw_affiliation_string': '*Novo Nordisk A/S, DK-2760 Måløv, Denmark; and', 'institution_ids': ['https://openalex.org/I189090001']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5001021182'], 'corresponding_institution_ids': ['https://openalex.org/I189090001'], 'apc_list': None, 'apc_paid': None, 'fwci': 6.891, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 129, 'citation_normalized_percentile': {'value': 0.999924, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '194', 'issue': '4', 'first_page': '1417', 'last_page': '1421'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T14165', 'display_name': 'Role of TREM-1 and Endocan in Inflammation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T14165', 'display_name': 'Role of TREM-1 and Endocan in Inflammation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/trem-1', 'display_name': 'TREM-1', 'score': 0.551102}], 'concepts': [{'id': 'https://openalex.org/C2776634448', 'wikidata': 'https://www.wikidata.org/wiki/Q206920', 'display_name': 'Peptidoglycan', 'level': 3, 'score': 0.8662583}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.729766}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6718954}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.60312265}, {'id': 'https://openalex.org/C116569031', 'wikidata': 'https://www.wikidata.org/wiki/Q899107', 'display_name': 'Ligand (biochemistry)', 'level': 3, 'score': 0.57707995}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5298072}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.526101}, {'id': 'https://openalex.org/C14036430', 'wikidata': 'https://www.wikidata.org/wiki/Q3736076', 'display_name': 'Function (biology)', 'level': 2, 'score': 0.50532633}, {'id': 'https://openalex.org/C88045685', 'wikidata': 'https://www.wikidata.org/wiki/Q174576', 'display_name': 'Activator (genetics)', 'level': 3, 'score': 0.48107767}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.43655753}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.39268273}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3421037}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2030924}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1595616}], 'mesh': [{'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020349', 'descriptor_name': 'Surface Plasmon Resonance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073871', 'descriptor_name': 'Triggering Receptor Expressed on Myeloid Cells-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1402303', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/194/4/1417.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4319313', 'pdf_url': 'https://europepmc.org/articles/pmc4319313?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319313', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25595774', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1402303', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/194/4/1417.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1601476460', 'https://openalex.org/W1892925516', 'https://openalex.org/W1970190307', 'https://openalex.org/W1971748489', 'https://openalex.org/W1996891899', 'https://openalex.org/W2007372372', 'https://openalex.org/W2012811488', 'https://openalex.org/W2110202168', 'https://openalex.org/W2112580008', 'https://openalex.org/W2128413447', 'https://openalex.org/W2128988773', 'https://openalex.org/W2141766281', 'https://openalex.org/W2146857507', 'https://openalex.org/W2156153766', 'https://openalex.org/W2167556553', 'https://openalex.org/W2170000318'], 'related_works': ['https://openalex.org/W4391065353', 'https://openalex.org/W2374919600', 'https://openalex.org/W2123750465', 'https://openalex.org/W2071136414', 'https://openalex.org/W2052779789', 'https://openalex.org/W2043705438', 'https://openalex.org/W2024451654', 'https://openalex.org/W1986837396', 'https://openalex.org/W1893905942', 'https://openalex.org/W1823527730'], 'abstract_inverted_index': {'Triggering': [0], 'receptor': [1, 10], 'expressed': [2], 'on': [3], 'myeloid': [4, 120], 'cells': [5], '(TREM)-1': [6], 'is': [7], 'an': [8, 39], 'orphan': [9], 'implicated': [11], 'in': [12, 21, 29, 86, 97, 129], 'innate': [13, 130], 'immune': [14, 30], 'activation.': [15], 'Inhibition': [16], 'of': [17, 38, 47, 69, 79, 100], 'TREM-1': [18, 48, 71, 75, 87, 109], 'reduces': [19], 'sepsis': [20], 'mouse': [22], 'models,': [23], 'suggesting': [24], 'a': [25, 44, 65, 108, 112], 'role': [26, 104], 'for': [27, 84, 105], 'it': [28], 'responses': [31], 'triggered': [32], 'by': [33, 115], 'bacteria.': [34], 'However,': [35], 'the': [36, 82, 91, 98], 'absence': [37, 99], 'identified': [40, 51], 'ligand': [41, 67], 'has': [42], 'hampered': [43], 'full': [45], 'understanding': [46], 'function.': [49], 'We': [50], 'complexes': [52], 'between': [53], 'peptidoglycan': [54, 62, 85], 'recognition': [55], 'protein': [56], '1': [57], '(PGLYRP1)': [58], 'and': [59, 72], 'bacterially': [60], 'derived': [61], 'that': [63, 90], 'constitute': [64], 'potent': [66], 'capable': [68], 'binding': [70], 'inducing': [73], 'known': [74], 'functions.': [76], 'Interestingly,': [77], 'multimerization': [78], 'PGLYRP1': [80, 106], 'bypassed': [81], 'need': [83], 'activation,': [88], 'demonstrating': [89], 'PGLYRP1/TREM-1': [92], 'axis': [93], 'can': [94, 118], 'be': [95], 'activated': [96], 'bacterial': [101], 'products.': [102], 'The': [103], 'as': [107], 'activator': [110], 'provides': [111], 'new': [113], 'mechanism': [114], 'which': [116], 'bacteria': [117], 'trigger': [119], 'cells,': [121], 'linking': [122], 'two': [123], 'known,': [124], 'but': [125], 'previously': [126], 'unrelated,': [127], 'pathways': [128], 'immunity.': [131]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2117532213', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 5}], 'updated_date': '2024-08-21T16:45:56.028473', 'created_date': '2016-06-24'}