Title: Serum Creatine Kinase and Lactate Dehydrogenase during Cardiac Irradiation
Abstract:ABSTRACT Thirty patients irradiated to a major part of the heart had serial determinations of serum total creatine kinase (S‐CK), creatine kinase subunit B (S‐CK‐B), total lactate dehydrogenase (S‐LD)...ABSTRACT Thirty patients irradiated to a major part of the heart had serial determinations of serum total creatine kinase (S‐CK), creatine kinase subunit B (S‐CK‐B), total lactate dehydrogenase (S‐LD) and lactate dehydrogenase isoenzyme 1 (S‐LD‐1) activity at the beginning, at the end and 14 months after radiotherapy. One patient had an elevated total S‐CK activity three months after radiotherapy, but none of the patients had an elevated S‐CK‐B activity during follow‐up. Three patients had elevated serum LD before irradiation, two patients during and two patients after radiotherapy, but only one patient had an elevated S‐LD‐1 activity, which decreased during irradiation. We conclude that the heart muscle is not injured by cardiac irradiation to such an extent that CK, CK‐B, LD and LD‐1 activities rise in serum, if moderate doses (39–62 Gy, NSD 1137–1775 rets) are delivered to the heart.Read More
Publication Year: 1987
Publication Date: 1987-01-12
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 4
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