Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2117296712', 'doi': 'https://doi.org/10.1200/jco.2004.06.037', 'title': 'Antiandrogen Withdrawal Alone or in Combination With Ketoconazole in Androgen-Independent Prostate Cancer Patients: A Phase III Trial (CALGB 9583)', 'display_name': 'Antiandrogen Withdrawal Alone or in Combination With Ketoconazole in Androgen-Independent Prostate Cancer Patients: A Phase III Trial (CALGB 9583)', 'publication_year': 2004, 'publication_date': '2004-03-12', 'ids': {'openalex': 'https://openalex.org/W2117296712', 'doi': 'https://doi.org/10.1200/jco.2004.06.037', 'mag': '2117296712', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15020604'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1200/jco.2004.06.037', 'pdf_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2004.06.037?role=tab', 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2004.06.037?role=tab', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007578304', 'display_name': 'Eric J. Small', 'orcid': 'https://orcid.org/0000-0003-3191-6268'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric J. Small', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053535513', 'display_name': 'Susan Halabi', 'orcid': 'https://orcid.org/0000-0003-4135-2777'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan Halabi', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113012755', 'display_name': 'Nancy A. Dawson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy A. Dawson', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088131964', 'display_name': 'Walter M. Stadler', 'orcid': 'https://orcid.org/0000-0002-0435-2527'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Walter M. Stadler', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025529463', 'display_name': 'Brian I. Rini', 'orcid': 'https://orcid.org/0000-0002-2212-080X'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian I. Rini', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034354367', 'display_name': 'Joel Picus', 'orcid': 'https://orcid.org/0000-0002-4038-936X'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joel Picus', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005450124', 'display_name': 'Preston Gable', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Preston Gable', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087773842', 'display_name': 'Frank M. Torti', 'orcid': 'https://orcid.org/0000-0003-3640-6902'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frank M. Torti', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108425439', 'display_name': 'Ellen B. Kaplan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ellen Kaplan', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059219836', 'display_name': 'Nicholas J. Vogelzang', 'orcid': 'https://orcid.org/0000-0002-7665-6079'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}, {'id': 'https://openalex.org/I4210087865', 'display_name': 'University of Chicago Medical Center', 'ror': 'https://ror.org/0076kfe04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087865']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas J. Vogelzang', 'raw_affiliation_strings': ['From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO'], 'affiliations': [{'raw_affiliation_string': 'From the University of California San Francisco, San Francisco, and US Naval Medical Center, University of California San Diego, San Diego, CA; Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, and Wake Forest Comprehensive Cancer Center, Winston-Salem, NC; Greenebaum Cancer Center, University of Maryland, Baltimore, MD; University of Chicago Medical Center, Chicago, IL; and Washington University Barnard Cancer Center, St Louis, MO', 'institution_ids': ['https://openalex.org/I126744593', 'https://openalex.org/I4210126298', 'https://openalex.org/I4210087865']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 20.182, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 503, 'citation_normalized_percentile': {'value': 0.99995, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '22', 'issue': '6', 'first_page': '1025', 'last_page': '1033'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11956', 'display_name': 'Sexual Differentiation and Disorders', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.43868586}, {'id': 'https://openalex.org/keywords/androgen-suppression', 'display_name': 'Androgen Suppression', 'score': 0.4178024}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.89997625}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.87728465}, {'id': 'https://openalex.org/C2781064554', 'wikidata': 'https://www.wikidata.org/wiki/Q407883', 'display_name': 'Ketoconazole', 'level': 3, 'score': 0.7974067}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.68202055}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.6202607}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5403237}, {'id': 'https://openalex.org/C2776476923', 'wikidata': 'https://www.wikidata.org/wiki/Q7725', 'display_name': 'Evening', 'level': 2, 'score': 0.51771754}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.45995274}, {'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.43868586}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.42543343}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.41928148}, {'id': 'https://openalex.org/C2778559712', 'wikidata': 'https://www.wikidata.org/wiki/Q4759442', 'display_name': 'Androgen suppression', 'level': 4, 'score': 0.4178024}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.37081596}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3506869}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.3030401}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.1613333}, {'id': 'https://openalex.org/C2779548794', 'wikidata': 'https://www.wikidata.org/wiki/Q578726', 'display_name': 'Antifungal', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C1276947', 'wikidata': 'https://www.wikidata.org/wiki/Q333', 'display_name': 'Astronomy', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007654', 'descriptor_name': 'Ketoconazole', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006854', 'descriptor_name': 'Hydrocortisone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006854', 'descriptor_name': 'Hydrocortisone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D007654', 'descriptor_name': 'Ketoconazole', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D007654', 'descriptor_name': 'Ketoconazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1200/jco.2004.06.037', 'pdf_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2004.06.037?role=tab', 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15020604', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1200/jco.2004.06.037', 'pdf_url': 'https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2004.06.037?role=tab', 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1580788756', 'https://openalex.org/W1854708637', 'https://openalex.org/W1885677122', 'https://openalex.org/W1907260682', 'https://openalex.org/W1960373985', 'https://openalex.org/W1979300931', 'https://openalex.org/W1990639292', 'https://openalex.org/W2013407137', 'https://openalex.org/W2013614953', 'https://openalex.org/W2036951632', 'https://openalex.org/W2045828086', 'https://openalex.org/W2049715100', 'https://openalex.org/W2074407985', 'https://openalex.org/W2103090668', 'https://openalex.org/W2108955823', 'https://openalex.org/W2109694492', 'https://openalex.org/W2117399653', 'https://openalex.org/W2118906905', 'https://openalex.org/W2120079339', 'https://openalex.org/W2126134811', 'https://openalex.org/W2134113204', 'https://openalex.org/W2151232297', 'https://openalex.org/W2155679349', 'https://openalex.org/W2160064859', 'https://openalex.org/W2165631552', 'https://openalex.org/W2171724045', 'https://openalex.org/W2337912524', 'https://openalex.org/W2340799873', 'https://openalex.org/W2396454073', 'https://openalex.org/W2464502417', 'https://openalex.org/W27570217', 'https://openalex.org/W4239330499', 'https://openalex.org/W4293241248'], 'related_works': ['https://openalex.org/W3148026613', 'https://openalex.org/W2468654524', 'https://openalex.org/W2429123467', 'https://openalex.org/W2165611177', 'https://openalex.org/W2120032813', 'https://openalex.org/W2092991204', 'https://openalex.org/W2080966978', 'https://openalex.org/W2036335596', 'https://openalex.org/W2022088631', 'https://openalex.org/W1816722347'], 'abstract_inverted_index': {'Purpose': [0], 'Antiandrogen': [1], 'withdrawal': [2], '(AAWD)': [3], 'results': [4], 'in': [5, 12, 18, 138, 149, 161, 169, 183, 197, 200, 217], 'a': [6, 117, 198], 'prostate-specific': [7], 'antigen': [8], '(PSA)': [9], 'response': [10], '(decline': [11], 'PSA': [13, 118, 163], 'level': [14], 'of': [15, 22, 44, 111, 123, 140, 174, 209, 240, 258], '≥': [16], '50%)': [17], '15%': [19], 'to': [20, 62, 121, 147, 252, 254], '30%': [21], 'androgen-independent': [23], 'prostate': [24], 'cancer': [25], '(AiPCa)': [26], 'patients.': [27], 'Thereafter,': [28], 'adrenal': [29, 201], 'androgen': [30, 202, 227], 'ablation': [31], 'with': [32, 49, 71, 106, 143, 152, 185, 190, 230, 232], 'agents': [33], 'such': [34], 'as': [35], 'ketoconazole': [36], '(K)': [37], 'is': [38], 'commonly': [39], 'utilized.': [40], 'The': [41], 'therapeutic': [42], 'effect': [43], 'AAWD': [45, 51, 64, 99, 114, 127, 144, 187, 221], 'alone': [46, 65, 100, 115, 145, 222], 'was': [47, 158, 192], 'compared': [48, 120, 146], 'simultaneous': [50, 129], 'and': [52, 56, 78, 128, 164, 171, 179, 195, 234], 'K': [53, 72, 130, 191, 213, 233, 248], 'therapy.': [54], 'Patients': [55, 93], 'Methods': [57], 'AiPCa': [58, 218], 'patients': [59, 112, 124, 141, 150, 175, 184], 'were': [60, 101, 136, 167, 180], 'randomized': [61], 'undergo': [63], '(n': [66], '=': [67, 91, 132, 155], '132),': [68], 'or': [69], 'together': [70], '(400': [73], 'mg': [74, 81, 86], 'orally': [75], '[po]': [76], 'tid)': [77], 'hydrocortisone': [79], '(30': [80], 'po': [82, 87], 'each': [83, 88], 'morning,': [84], '10': [85], 'evening;': [89], 'n': [90], '128).': [92], 'who': [94, 125], 'developed': [95], 'progressive': [96, 244], 'disease': [97, 210, 245], 'after': [98], 'eligible': [102], 'for': [103], 'deferred': [104, 177], 'treatment': [105, 231], 'K.': [107, 259], 'Results': [108], 'Eleven': [109], 'percent': [110], 'undergoing': [113], 'had': [116], 'response,': [119], '27%': [122], 'underwent': [126], '(P': [131, 154], '.0002).': [133], 'Objective': [134], 'responses': [135, 166], 'observed': [137, 168], '2%': [139], 'treated': [142, 151], '20%': [148], 'AAWD/K': [153], '.02).': [156], 'There': [157], 'no': [159], 'difference': [160], 'survival.': [162], 'objective': [165], '32%': [170], '7%,': [172], 'respectively,': [173], 'receiving': [176], 'K,': [178], 'more': [181], 'common': [182], 'prior': [186], 'response.': [188], 'Treatment': [189], 'well': [193], 'tolerated,': [194], 'resulted': [196], 'decline': [199], 'levels,': [203], 'which': [204], 'rose': [205], 'at': [206, 237], 'the': [207, 238, 255], 'time': [208, 239], 'progression.': [211], 'Conclusion': [212], 'has': [214, 223], 'modest': [215], 'activity': [216], 'patients,': [219], 'while': [220, 246], 'minimal': [224], 'activity.': [225], 'Adrenal': [226], 'levels': [228], 'fall': [229], 'then': [235], 'climb': [236], 'progression,': [241], 'suggesting': [242], 'that': [243], 'on': [247], 'may': [249], 'be': [250], 'due': [251], 'tachyphylaxis': [253], 'adrenolytic': [256], 'properties': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2117296712', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 18}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 31}, {'year': 2014, 'cited_by_count': 50}, {'year': 2013, 'cited_by_count': 45}, {'year': 2012, 'cited_by_count': 62}], 'updated_date': '2024-12-10T08:00:43.079783', 'created_date': '2016-06-24'}