Publication Information

{'id': 'https://openalex.org/W2117220263', 'doi': None, 'title': 'P2Y12 inhibitors in acute coronary syndromes: which and when?', 'display_name': 'P2Y12 inhibitors in acute coronary syndromes: which and when?', 'publication_year': 2013, 'publication_date': '2013-10-08', 'ids': {'openalex': 'https://openalex.org/W2117220263', 'mag': '2117220263', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24093982'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24093982', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110510607', 'display_name': 'Prem Pais', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145302', 'display_name': "St.John's Medical College Hospital", 'ror': 'https://ror.org/04z7fc725', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I4210129261', 'https://openalex.org/I4210145302']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Prem Pais', 'raw_affiliation_strings': ["Department of Medicine, Clinical Trials Division, St John's Medical College, Bengaluru 5600334, Karnataka, India, [email protected]."], 'affiliations': [{'raw_affiliation_string': "Department of Medicine, Clinical Trials Division, St John's Medical College, Bengaluru 5600334, Karnataka, India, [email protected].", 'institution_ids': ['https://openalex.org/I4210145302']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5110510607'], 'corresponding_institution_ids': ['https://openalex.org/I4210145302'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '26', 'issue': '2', 'first_page': '84', 'last_page': '90'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Venous Thromboembolism Diagnosis and Management', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thienopyridine', 'display_name': 'Thienopyridine', 'score': 0.9002609}], 'concepts': [{'id': 'https://openalex.org/C2777028646', 'wikidata': 'https://www.wikidata.org/wiki/Q416232', 'display_name': 'Prasugrel', 'level': 4, 'score': 0.97641116}, {'id': 'https://openalex.org/C2780890252', 'wikidata': 'https://www.wikidata.org/wiki/Q420542', 'display_name': 'Ticagrelor', 'level': 4, 'score': 0.9517393}, {'id': 'https://openalex.org/C2777849778', 'wikidata': 'https://www.wikidata.org/wiki/Q410237', 'display_name': 'Clopidogrel', 'level': 3, 'score': 0.93098533}, {'id': 'https://openalex.org/C2779837110', 'wikidata': 'https://www.wikidata.org/wiki/Q3074941', 'display_name': 'Thienopyridine', 'level': 4, 'score': 0.9002609}, {'id': 'https://openalex.org/C49059817', 'wikidata': 'https://www.wikidata.org/wiki/Q14916330', 'display_name': 'P2Y12', 'level': 4, 'score': 0.8631345}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.79194605}, {'id': 'https://openalex.org/C2777698277', 'wikidata': 'https://www.wikidata.org/wiki/Q266018', 'display_name': 'Acute coronary syndrome', 'level': 3, 'score': 0.7224394}, {'id': 'https://openalex.org/C2777628954', 'wikidata': 'https://www.wikidata.org/wiki/Q18216', 'display_name': 'Aspirin', 'level': 2, 'score': 0.71328264}, {'id': 'https://openalex.org/C140840227', 'wikidata': 'https://www.wikidata.org/wiki/Q3737532', 'display_name': 'CYP2C19', 'level': 4, 'score': 0.44601607}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4385309}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.417711}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.41684696}, {'id': 'https://openalex.org/C2778213512', 'wikidata': 'https://www.wikidata.org/wiki/Q844935', 'display_name': 'Coronary artery disease', 'level': 2, 'score': 0.41407076}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33377504}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.18421724}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D058921', 'descriptor_name': 'Purinergic P2Y Receptor Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077144', 'descriptor_name': 'Clopidogrel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000068799', 'descriptor_name': 'Prasugrel Hydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058921', 'descriptor_name': 'Purinergic P2Y Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052999', 'descriptor_name': 'Quinazolinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052999', 'descriptor_name': 'Quinazolinones', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000077486', 'descriptor_name': 'Ticagrelor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24093982', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.87, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W113146421', 'https://openalex.org/W1553345686', 'https://openalex.org/W1569796594', 'https://openalex.org/W158289124', 'https://openalex.org/W1976361153', 'https://openalex.org/W1985059672', 'https://openalex.org/W1990963444', 'https://openalex.org/W1998764586', 'https://openalex.org/W2001688139', 'https://openalex.org/W2006624707', 'https://openalex.org/W2007957848', 'https://openalex.org/W2058217708', 'https://openalex.org/W2062155815', 'https://openalex.org/W2065390746', 'https://openalex.org/W2073399805', 'https://openalex.org/W2081548185', 'https://openalex.org/W2083488580', 'https://openalex.org/W2097546384', 'https://openalex.org/W2100089051', 'https://openalex.org/W2100209149', 'https://openalex.org/W2105005467', 'https://openalex.org/W2109577952', 'https://openalex.org/W2113671215', 'https://openalex.org/W2124078235', 'https://openalex.org/W2127042742', 'https://openalex.org/W2140501627', 'https://openalex.org/W2144206796', 'https://openalex.org/W2145425156', 'https://openalex.org/W2152376036', 'https://openalex.org/W2157833432', 'https://openalex.org/W2161055506', 'https://openalex.org/W2163050713', 'https://openalex.org/W2168722424', 'https://openalex.org/W2169387542', 'https://openalex.org/W2170312517', 'https://openalex.org/W2170949977', 'https://openalex.org/W2529190803', 'https://openalex.org/W311320695'], 'related_works': ['https://openalex.org/W2401127246', 'https://openalex.org/W2292174085', 'https://openalex.org/W2290033884', 'https://openalex.org/W2127586058', 'https://openalex.org/W2117220263', 'https://openalex.org/W2115826049', 'https://openalex.org/W2110314351', 'https://openalex.org/W2086997288', 'https://openalex.org/W1995953692', 'https://openalex.org/W1706301048'], 'abstract_inverted_index': {'Acute': [0], 'coronary': [1, 10], 'syndromes': [2], '(ACS)': [3], 'are': [4, 27, 36, 62, 138, 155], 'the': [5, 28, 39, 45, 76, 85, 99, 110, 113, 210], 'commonest': [6], 'acute': [7], 'manifestation': [8], 'of': [9, 17, 41, 50, 66, 78, 90, 107, 127, 165, 172, 217], 'artery': [11], 'disease': [12], 'and': [13, 19, 23, 101, 122, 150, 154, 182, 214], 'a': [14, 104, 119, 124, 147], 'major': [15, 185], 'cause': [16], 'hospitalization': [18], 'death.': [20], 'Plaque': [21], 'rupture': [22], 'subsequent': [24], 'platelet': [25], 'activation': [26], 'key': [29], 'factors': [30], 'in': [31, 38, 56, 75, 132, 188, 195, 205, 221], 'its': [32], 'pathogenesis.': [33], 'Platelet': [34, 58], 'inhibitors': [35, 61, 81, 220], 'crucial': [37], 'management': [40, 77], 'ACS.': [42, 57, 79], 'Aspirin': [43], 'remains': [44], 'standard': [46], 'antiplatelet': [47, 52, 67, 152], 'but': [48], 'use': [49], 'dual': [51], 'drugs': [53], 'is': [54, 200], 'beneficial': [55], 'P2Y12': [59, 80, 218], 'receptor': [60, 100, 219], 'an': [63], 'important': [64], 'group': [65, 89, 134], 'compounds': [68, 115, 131], 'that': [69, 171, 180], 'can': [70], 'be': [71, 160], 'combined': [72], 'with': [73, 98, 170], 'aspirin': [74], 'may': [82], 'belong': [83], 'to': [84, 140, 159, 191, 197], 'thienopyridine': [86], 'or': [87, 137], 'nonthienopyridine': [88], 'compounds.': [91], 'The': [92, 143], 'former': [93], '(clopidogrel,': [94], 'prasugrel)': [95], 'combine': [96], 'irreversibly': [97], 'therefore': [102], 'have': [103, 118, 135, 146, 178], 'prolonged': [105], 'duration': [106, 126], 'action.': [108, 128], 'On': [109], 'other': [111], 'hand,': [112], 'non-thienopyridine': [114], '(ticagrelor,': [116], 'elinogrel)': [117], 'reversible': [120], 'action': [121], 'hence': [123], 'shorter': [125], 'Several': [129], 'new': [130], 'this': [133], 'become': [136, 141], 'likely': [139, 158], 'available.': [142], 'newer': [144], 'agents': [145], 'more': [148], 'uniform': [149], 'complete': [151], 'effect': [153], 'much': [156], 'less': [157], 'affected': [161], 'by': [162, 202], 'genetic': [163], 'variability': [164], 'CYP2C19': [166], 'enzyme': [167], 'activity': [168], 'compared': [169, 190], 'clopidogrel.': [173], 'Large': [174], 'phase': [175], '3': [176], 'trials': [177], 'shown': [179], 'ticagrelor': [181], 'prasugrel': [183], 'reduce': [184], 'cardiovascular': [186], 'events': [187], 'ACS': [189], 'clopidogrel': [192], 'when': [193], 'given': [194], 'addition': [196], 'aspirin.': [198], 'This': [199, 207], 'accompanied': [201], 'some': [203], 'increase': [204], 'bleeding.': [206], 'review': [208], 'discusses': [209], 'properties,': [211], 'clinical': [212, 222], 'profile': [213], 'possible': [215], 'place': [216], 'practice.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2117220263', 'counts_by_year': [], 'updated_date': '2024-12-10T14:25:24.384481', 'created_date': '2016-06-24'}