Regulatory Roles for APJ, a Seven-transmembrane Receptor Related to Angiotensin-type 1 Receptor in Blood Pressure in Vivo

Name: Work Video:
Duration: 3 min 30 s
Junji Ishida; Tatsuo Hashimoto; Yasumi Hashimoto; Shiro Nishiwaki; Taku Iguchi; Shuichi Harada; Takeshi Sugaya; Hitomi Matsuzaki; Rie Yamamoto; Naotaka Shiota; Hideki Okunishi; Minoru Kihara; Satoshi Umemura; Fumihiro Sugiyama; Ken‐ichi Yagami; Yoshitoshi Kasuya; Naoki Mochizuki; Akiyoshi Fukamizu
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232, 240, 255, 262, 271, 278, 319, 352, 370, 395, 400, 408, 423, 544, 590, 803, 819, 973, 989, 996, 999, 1009, 1043, 1060, 1144, 1158, 1186, 1201, 1210, 1217, 1457, 1477, 1501, 1526, 1561, 1645, 1675, 1713, 1717, 1731, 1768, 1798, 1810, 1832, 1869, 1881, 1886, 1910, 1917, 1925, 1928, 1937, 1946, 1973, 2009, 2021, 2026, 2037, 2051, 2065, 2091, 2132, 2147, 2164, 2273, 2281, 2316, 2328, 2344, 2361, 2374, 2379, 2394, 2418, 2448, 2471, 2485, 2507, 2567, 2598, 2606, 2646, 2653, 2663, 2686, 2786, 2791, 2801, 2871, 2886, 2982, 2988, 2991, 2999, 3024, 3029, 3143, 3243, 3310, 3321, 3340, 3355, 3369, 3391, 3399, 3408, 3568, 3575, 3730, 3760, 3770, 3776, 3781, 3822, 4028, 4047, 4052, 4058, 4066, 4075, 4112, 4129, 4137, 4147, 4164, 4211, 4223, 4252, 4273, 4277, 4313, 4326, 4377, 4412, 4418, 4420, 4443, 4456, 4510, 4626, 4713, 4725, 4731, 4782, 4790, 4793, 4832, 4881, 4910, 4920, 4933, 4950, 4992, 5026, 5094, 5110, 5214, 5235, 5254, 5307, 5313, 5341], 'blood': [34, 54, 77, 151, 233, 253, 276, 350, 553, 976, 1048, 1571, 1679, 1695, 1756, 1785, 1858, 1903, 1912, 2331, 2352, 2809, 2837, 2873, 3015, 3319, 3338, 3373, 3395, 3415, 3556, 3573, 3617, 3742, 3784, 4168, 4206, 4221, 4262, 4285, 4299, 4721, 4734, 4749, 4759, 4780, 4807, 4852, 4887, 4944, 4995, 5092, 5138, 5219], 'pressure.': [35, 234, 2874, 3557, 4750, 5139], 'To': [36, 235, 1132, 3536, 4602, 4751], 'investigate': [37, 236], 'physiological': [39, 238, 416, 815, 2668, 4457, 4931], 'functions': [40, 239, 417, 1008, 5312], 'APJ,': [42, 241, 3030], 'we': [43, 242, 1038, 2461, 2658, 2681, 2805, 3540, 4133, 4239, 4769, 4998], 'have': [44, 243, 3250, 3792], 'generated': [45, 244, 1317, 1388, 1450, 4119, 4999], 'mice': [46, 58, 65, 81, 130, 135, 156, 245, 257, 264, 280, 329, 334, 355, 1077, 1315, 1386, 1440, 1453, 1481, 1623, 1652, 1844, 1942, 2176, 2340, 2549, 2633, 2665, 2744, 2782, 2824, 2827, 2993, 3137, 3301, 3323, 3342, 3357, 3381, 3422, 4197, 4289, 4303, 4335, 4619, 4654, 4905, 4939, 4962, 5002, 5019, 5028, 5097, 5112, 5146, 5240, 5258], 'lacking': [47, 246], 'gene': [49, 248, 1148, 1160, 1177, 1204, 2459, 2480, 2648, 2699, 5238, 5242], 'encoding': [50, 249], 'APJ.': [51, 250, 1010, 3148], 'The': [52, 70, 251, 269, 518, 1173, 1192, 1253, 1516, 1700, 1770, 1790, 1908, 1993, 2081, 2205, 2349, 2547, 2603, 3240, 3307, 3727, 3779, 4026, 4250, 4297, 4787, 4936], 'base-line': [53, 150, 252, 349, 2835, 2872, 3571, 5091], 'pressure': [55, 78, 152, 254, 277, 351, 554, 977, 1049, 1696, 1757, 1777, 1786, 1859, 1904, 1913, 2332, 2353, 2356, 2398, 2810, 2838, 3016, 3320, 3339, 3374, 3396, 3416, 3574, 3618, 3743, 3785, 3825, 4169, 4207, 4222, 4263, 4286, 4300, 4722, 4735, 4760, 4781, 4808, 4853, 4888, 4945, 4996, 5093, 5220], 'APJ-deficient': [57, 103, 129, 134, 256, 302, 328, 333, 1021, 1459, 1837, 1934, 1940, 2175, 2449, 2823, 2992, 3136, 3341, 3380, 4196, 4302, 4618, 4653, 4685, 4785, 4961, 5009], 'equivalent': [60, 259, 2644, 4487], 'to': [61, 98, 141, 260, 297, 340, 435, 1003, 1512, 1522, 1775, 1915, 2061, 2210, 2218, 2269, 2300, 2311, 2371, 2389, 2400, 2528, 2537, 2552, 2641, 2762, 3135, 3138, 3159, 3249, 3401, 3544, 3732, 3736, 3797, 4041, 4176, 4187, 4488, 4516, 4746, 4846, 4900, 4916, 4968, 4988, 5082, 5135, 5152], 'wild-type': [64, 80, 263, 279, 1938, 2173, 2627, 2826, 3000, 3322, 3356, 3376, 4152, 4194, 4267, 4288, 4334, 4616, 4651, 4679, 4783, 4938, 4979, 5027], 'steady': [68, 267, 2816, 3419, 4824], 'state.': [69, 268, 2817], 'administration': [71, 270, 818, 1712, 1767, 1880, 1885, 2373, 2378, 2417, 3023, 3309, 3368, 3567, 3729, 3759, 4210, 4234, 4272, 4315, 4376, 4775, 4845], 'apelin': [73, 99, 272, 298, 602, 647, 806, 820, 930, 962, 974, 990, 1918, 2880, 3134, 3144, 3311, 3331, 3370, 3392, 3542, 3601, 3731, 3761, 3782, 3980, 4053, 4106, 4242, 4253, 4278, 4309, 4337, 4378, 4623, 4674, 4696, 5255], 'transiently': [74, 273, 3019, 3312], 'decreased': [75, 274, 3018, 3315], 'hypertensive': [84, 89, 283, 288, 453, 1029, 3534, 3547, 3765, 3789], 'model': [85, 284, 3548, 3790, 5331], 'animal,': [86, 285, 3549], 'spontaneously': [88, 287, 452, 1028], 'rat.': [90, 289], 'On': [91, 290, 926, 3326, 4956], 'other': [93, 292, 928, 2647, 3328, 4745], 'hand,': [94, 293, 929, 3329], 'this': [95, 294, 598, 969, 1013, 1447, 3389, 3538, 5246], 'hypotensive': [96, 183, 295, 382, 823, 3528, 3754, 4030, 4330, 4718, 5252, 5284], 'response': [97, 107, 140, 296, 306, 339, 4146, 4818], 'abolished': [101, 300], 'mice.': [104, 175, 303, 374, 1462, 2546, 2602, 4153, 4268, 4786, 4902, 5012], 'This': [105, 304, 4202, 4690, 5329], 'apelin-induced': [106, 118, 305, 317, 4029, 4711], 'inhibited': [109, 308], 'by': [110, 309, 1015, 1032, 1305, 1318, 1508, 1575, 1684, 1795, 1897, 2150, 2184, 2201, 2251, 2426, 2496, 2541, 2564, 3020, 3162, 3756, 4120, 4307, 4336, 4434, 4453, 4467, 4473, 4503, 4633, 4658, 4673, 4820, 4829, 4897, 4946, 5007, 5241, 5271, 5287, 5297], 'pretreatment': [111, 310], 'nitric-oxide': [114, 122, 313, 321, 4139], 'synthase': [115, 123, 314, 322, 4140], 'inhibitor,': [116, 315, 4141], 'phosphorylation': [119, 318, 2272, 4474, 4498, 4625, 4636, 4672, 4712], 'endothelial': [121, 126, 320, 325, 464, 1034, 2057, 2083, 2101, 2148, 2170, 4612, 4648, 4680, 4686, 4701, 5274], 'lung': [125, 324, 1476, 1936, 2689, 2694], 'cells': [127, 326, 938, 1035, 1256, 1263, 1302, 1322, 2058, 2084, 2116, 2124, 2149, 2171, 2487, 2510, 4613, 4649, 4666, 4681, 4687, 4702, 5275], 'from': [128, 327, 479, 594, 1036, 1071, 1075, 1180, 1451, 1472, 1931, 2105, 2172, 2404, 2779, 2997, 3152, 4172, 4183, 4431, 4615, 4650, 5277], 'disappeared.': [131, 330], 'In': [132, 331, 2637, 3955, 4269, 4984, 5231, 5269, 5300], 'addition,': [133, 332, 3956, 5270], 'showed': [136, 335], 'an': [137, 336, 412, 2319, 4255, 4941], 'increased': [138, 337, 4170, 4380, 4942, 4966], 'vasopressor': [139, 338, 4767, 4895, 5084, 5157, 5267], 'most': [143, 342], 'potent': [144, 343, 965], 'vasoconstrictor': [145, 344], 'angiotensin': [146, 197, 345, 396, 538, 2362, 2395, 2401, 2419, 3970, 4773, 4794, 4843, 4922, 4934, 4951, 4971, 5155, 5227], 'II,': [147, 346, 539, 2396], 'double': [154, 353, 1024, 5000, 5095], 'mutant': [155, 354, 2601, 2632, 2743, 2781, 5096], 'homozygous': [157, 356, 2554, 2600, 2631, 2679, 2742, 2780, 5098], 'for': [158, 357, 415, 537, 1137, 1441, 1538, 1707, 1754, 1764, 1988, 2046, 2110, 2193, 2386, 2412, 2430, 2583, 2654, 2666, 2868, 3388, 3979, 4842, 4913, 5003, 5099, 5250, 5335, 5350, 5354, 5368], 'both': [159, 358, 4810, 5100], 'angiotensin-type': [162, 172, 361, 371, 437, 446, 4882], '1a': [163, 173, 362, 372], 'significantly': [166, 365, 3314, 3737, 4379, 4657, 5106], 'elevated': [167, 366, 5105], 'compared': [168, 367, 4034, 4663, 4977, 5023, 5107], 'receptor-deficient': [174, 373], 'These': [176, 375, 2770, 3361, 4403, 5126], 'results': [177, 376, 2771, 3362], 'demonstrate': [178, 377, 3364], 'exerts': [181, 380, 547], 'effect': [184, 383, 824, 3529, 3755, 4331, 4719, 5253, 5285], 'vivo': [186, 385, 419, 1007, 3835, 5260, 5339], 'plays': [188, 387, 411, 4706, 4755, 5262], 'counterregulatory': [190, 389, 4764, 4892, 5264], 'role': [191, 390, 414, 4125, 4439, 4709, 4757, 4880, 4991, 5265, 5340], 'against': [192, 391, 2358, 4143, 4328, 4766, 4894, 5222, 5266], 'pressor': [194, 393, 549, 4817], 'action': [195, 394, 550, 972, 3390, 4324, 4411, 5158], 'II.': [198, 397, 2420, 4935], 'A': [398, 2752], 'family': [399], 'G': [401, 473], 'protein-coupled': [402, 474], 'receptors': [403], 'bind': [404], 'large': [406], 'variety': [407, 4455], 'ligands': [409], 'essential': [413, 2867], 'including': [420, 653, 1153, 4062, 4461, 5226, 5319], 'maintenance': [422, 2870], 'homeostasis': [424], 'system.': [428, 4117], '(a': [430], 'putative': [431], 'protein': [433, 4504], 'related': [434], '1': [438, 447, 2387, 4914], '(AT1))': [440], '1The': [441], 'abbreviations': [442], 'used': [443, 1445, 1529, 2659, 3561, 4838], 'are:': [444], 'AT1,': [445, 529], 'receptor;': [448], 'WKY,': [449], 'Wistar-Kyoto;': [450], 'SHR,': [451, 3550], 'rat;': [454], 'DMEM,': [455, 2011], "Dulbecco's": [456], 'modified': [457], "Eagle's": [458], 'medium;': [459], 'NO,': [460], 'nitric': [461, 4114], 'oxide;': [462], 'eNOS,': [463, 4610, 4714], 'NO': [465, 2166, 4118, 4422], 'synthase;': [466], 'l-NAME,': [467, 1882, 4142, 4165], 'NG-nitro-l-arginine': [468], 'methyl': [469], 'ester.': [470], 'isolated': [478, 1070, 1471], 'human': [480, 933, 1126, 4482], 'genomic': [481, 1063], 'DNA': [482, 1064, 2569], 'using': [483, 1016, 1033, 1308, 1482, 1582, 1649, 1841, 2260, 4634, 5272], 'polymerase': [485], 'chain': [486], 'reaction': [487, 2198], "(1O'Dowd": [488, 556], 'B.F.': [489, 557, 874, 2936, 3080, 3474, 3675], 'Heiber': [490, 558], 'M.': [491, 559, 610, 632, 662, 684, 708, 722, 751, 844, 898, 1101, 1276, 1336, 1366, 1415, 1546, 2703, 2725, 2906, 2952, 2964, 3050, 3104, 3168, 3190, 3214, 3228, 3260, 3282, 3444, 3498, 3645, 3699, 3845, 3855, 3877, 3881, 3895, 3929, 4005, 4093, 4360, 5055], 'Chan': [492, 560], 'A.': [493, 503, 561, 571, 735, 828, 1097, 1105, 1368, 1374, 1411, 1419, 1550, 1591, 2890, 2956, 2962, 3034, 3428, 3629, 3915, 3917, 3921, 4007, 4569, 5051, 5059, 5189], 'Heng': [494, 562], 'H.H.': [495, 563], 'Tsui': [496, 564], 'L.C.': [497, 565], 'Kennedy': [498, 566, 2955], 'J.L.': [499, 567], 'Shi': [500, 568], 'X.': [501, 569, 910, 3116, 3510, 3711], 'Petronis': [502, 570], 'George': [504, 572, 871, 2933, 3077, 3471, 3672], 'S.R.': [505, 573, 872, 946, 2934, 3078, 3472, 3673], 'Nguyen': [506, 574, 861, 2923, 3067, 3461, 3662], 'T.': [507, 575, 616, 628, 678, 862, 864, 1079, 1087, 1230, 1268, 1270, 1278, 1328, 1330, 1338, 1393, 1401, 1548, 1603, 2719, 2924, 2926, 3068, 3070, 3184, 3276, 3462, 3464, 3663, 3665, 3937, 3945, 3997, 4529, 5033, 5041, 5179, 5197], 'Gene': [508, 576, 1056], '(Amst.).': [509, 577], '1993;': [510, 578, 1245, 1289, 1349, 1613], '136:': [511, 579], '355-360Crossref': [512, 580], 'PubMed': [513, 581, 640, 696, 729, 759, 795, 852, 880, 904, 921, 955, 1119, 1248, 1292, 1352, 1433, 1494, 1619, 2737, 2914, 2942, 2974, 3058, 3086, 3110, 3127, 3202, 3235, 3294, 3452, 3480, 3504, 3521, 3653, 3681, 3705, 3722, 3863, 3903, 3950, 4021, 4099, 4366, 4549, 4576, 4597, 4872, 5073, 5173, 5202], 'Scopus': [514, 582, 641, 697, 730, 760, 796, 853, 881, 905, 922, 956, 1120, 1249, 1293, 1353, 1434, 1495, 2738, 2915, 2943, 2975, 3059, 3087, 3111, 3128, 3203, 3236, 3295, 3453, 3481, 3505, 3522, 3654, 3682, 3706, 3723, 3864, 3904, 3951, 4022, 4100, 4367, 4550, 4577, 4598, 4873, 5074, 5174, 5203], '(687)': [515, 583], 'Google': [516, 584, 643, 699, 732, 762, 798, 855, 883, 907, 924, 958, 1122, 1251, 1295, 1355, 1383, 1436, 1497, 1558, 1620, 2740, 2917, 2945, 2977, 3061, 3089, 3113, 3130, 3205, 3238, 3297, 3455, 3483, 3507, 3524, 3656, 3684, 3708, 3725, 3866, 3906, 3953, 4024, 4102, 4369, 4552, 4579, 4600, 4875, 5076, 5176, 5205], 'Scholar).': [517, 585, 644, 925, 1252, 1296, 1384, 1437, 1498, 1559, 1621, 3131, 3239, 3298, 3726, 3954, 4025, 4601, 5077, 5206], 'has': [520, 3011, 3246, 3801, 4122, 4436, 5131], '31%': [522], 'amino': [523, 3165], 'acid': [524, 3155], 'sequence': [525, 4484], 'homology': [526], 'but': [530, 2979, 3377, 3767, 4682], 'does': [532], 'not': [533, 2161, 2620, 2635, 2829, 2866, 2995, 3008, 3359, 3378, 3793, 4236, 4305, 4395, 4683, 4827], 'display': [534], 'specific': [535, 1000], 'binding': [536], 'which': [540, 2062, 4715], 'ligand': [543, 589, 3028], 'AT1': [545, 1127, 4821, 5229], 'Recently,': [586], 'bovine': [595, 2098, 2106, 2190, 4489], 'stomach,': [596], 'peptide': [599, 4243, 4310], 'named': [601], '(for': [603], 'ligand)': [606], '(2Tatemoto': [607], 'K.': [608, 747, 840, 886, 888, 896, 1083, 1089, 1093, 1103, 1107, 1362, 1372, 1376, 1397, 1403, 1407, 1417, 1421, 1593, 1607, 1609, 2902, 2950, 3046, 3092, 3094, 3102, 3440, 3486, 3488, 3496, 3641, 3687, 3689, 3697, 3995, 4081, 4083, 4091, 4348, 4350, 4358, 4565, 5037, 5043, 5047, 5057, 5061], 'Hosoya': [609, 707, 3213], 'Habata': [611, 669, 703, 2710, 3175, 3209, 3267], 'Y.': [612, 620, 664, 670, 702, 704, 868, 1095, 1240, 1272, 1280, 1284, 1332, 1340, 1344, 1358, 1370, 1409, 2705, 2711, 2930, 3074, 3170, 3176, 3208, 3210, 3262, 3268, 3468, 3669, 4563, 5049, 5187], 'Fujii': [613, 667, 709, 2708, 3173, 3215, 3265], 'R.': [614, 668, 710, 860, 2709, 2922, 3066, 3174, 3216, 3266, 3460, 3661, 3887, 3891, 3919, 3931, 4590], 'Kakegawa': [615], 'Zou': [617, 889, 3095, 3489, 3690, 4084, 4351], 'M.X.': [618, 890, 3096, 3490, 3691, 4085, 4352], 'Kawamata': [619, 663, 2704, 3169, 3261], 'Fukusumi': [621, 665, 705, 2706, 3171, 3211, 3263], 'S.': [622, 624, 666, 672, 676, 706, 712, 745, 838, 1081, 1091, 1232, 1242, 1274, 1286, 1334, 1346, 1395, 1405, 1601, 2707, 2713, 2717, 2900, 2948, 2966, 3044, 3172, 3178, 3182, 3212, 3218, 3264, 3270, 3274, 3438, 3639, 3843, 3849, 4003, 4531, 4582, 5035, 5045, 5185], 'Hinuma': [623, 671, 711, 2712, 3177, 3217, 3269], 'Kitada': [625, 673, 715, 2714, 3179, 3221, 3271], 'C.': [626, 674, 716, 753, 773, 846, 2715, 2908, 2960, 3052, 3180, 3222, 3272, 3446, 3647, 3983, 4588, 5183], 'Kurokawa': [627, 677, 2718, 3183, 3275], 'Onda': [629, 679, 717, 2720, 3185, 3223, 3277], 'H.': [630, 680, 718, 1099, 1236, 1413, 2721, 3186, 3224, 3278, 3847, 3857, 3893, 3939, 5053], 'Fujino': [631, 683, 721, 2724, 3189, 3227, 3281], 'Biochem.': [633, 1244, 1288, 1348, 1490, 2967, 3896], 'Biophys.': [634, 724, 2968, 3230, 3897], 'Res.': [635, 2969, 3859, 3898], 'Commun.': [636, 2970, 3899], '1998;': [637], '251:': [638], '471-476Crossref': [639], '(1349)': [642], 'several': [651, 3160], 'tissues': [652, 5318], 'central': [658, 4124, 5321], 'nervous': [659, 5322], 'systems': [660, 4741, 5325], '(3Hosoya': [661, 2702, 3167, 3259], 'Honda': [675, 2716, 3181, 3273], 'Nishimura': [681, 719, 2722, 3187, 3225, 3279], 'O.': [682, 720, 2723, 3188, 3226, 3280, 3875], 'J.': [685, 754, 790, 847, 875, 916, 950, 1108, 1364, 1422, 1552, 1610, 2726, 2909, 2937, 3053, 3081, 3122, 3191, 3283, 3447, 3475, 3516, 3648, 3676, 3717, 3851, 3853, 3991, 3993, 4010, 4561, 5062], 'Biol.': [686, 1109, 1423, 1611, 2727, 3192, 3284, 4011, 4540, 5063], 'Chem.': [687, 1110, 1424, 1612, 2728, 3193, 3285, 4012, 5064], '2000;': [688, 877, 1555, 2729, 2939, 3083, 3194, 3286, 3477, 3678], '275:': [689, 2730, 3195, 3287], '21061-21067Abstract': [690, 2731, 3196, 3288], 'Full': [691, 693, 1114, 1116, 1428, 1430, 1616, 2732, 2734, 3197, 3199, 3289, 3291, 4016, 4018, 4544, 4546, 5068, 5070], 'Text': [692, 694, 1115, 1117, 1429, 1431, 1617, 2733, 2735, 3198, 3200, 3290, 3292, 4017, 4019, 4545, 4547, 5069, 5071], 'PDF': [695, 1118, 1432, 1618, 2736, 3201, 3293, 4020, 4548, 5072], '(430)': [698, 2739, 3204, 3296], 'Scholar,': [700, 733, 763, 856, 884, 908, 1356, 2918, 2946, 3062, 3090, 3114, 3206, 3456, 3484, 3508, 3657, 3685, 3709, 3867, 3907, 4553, 4580, 5177], '4Kawamata': [701, 3207], 'Nishizawa': [713, 3219], 'N.': [714, 738, 831, 1234, 1238, 1282, 1342, 1488, 1605, 2893, 3037, 3220, 3431, 3632], 'Biochim.': [723, 3229], 'Acta.': [725, 3231], '2001;': [726, 756, 849, 901, 952, 2911, 3055, 3107, 3232, 3449, 3501, 3650, 3702, 4096, 4363], '1538:': [727, 3233], '162-171Crossref': [728, 3234], '(435)': [731, 3237], '5Reaux': [734], 'De': [736, 829, 2891, 3035, 3429, 3630], 'Mota': [737, 830, 2892, 3036, 3430, 3631], 'Skultetyova': [739, 832, 2894, 3038, 3432, 3633], 'I.': [740, 833, 892, 2895, 3039, 3098, 3433, 3492, 3634, 3693, 3837, 3873, 4087, 4354, 4527, 4584, 5193], 'Lenkei': [741, 834, 2896, 3040, 3434, 3635], 'Z.': [742, 835, 2897, 3041, 3435, 3636, 3889, 3941], 'El': [743, 836, 2898, 3042, 3436, 3637], 'Messari': [744, 837, 2899, 3043, 3437, 3638], 'Gallatz': [746, 839, 2901, 3045, 3439, 3640], 'Corvol': [748, 841, 2903, 3047, 3441, 3642], 'P.': [749, 787, 842, 1486, 2904, 3048, 3442, 3643, 3839, 3985, 4009], 'Palkovits': [750, 843, 2905, 3049, 3443, 3644], 'Llorens-Cortes': [752, 845, 2907, 3051, 3445, 3646], 'Neurochem.': [755, 791, 848, 876, 2910, 2938, 3054, 3082, 3448, 3476, 3649, 3677], '77:': [757, 850, 2912, 3056, 3450, 3651], '1085-1096Crossref': [758, 851, 2913, 3057, 3451, 3652], '(319)': [761, 854, 2916, 3060, 3454, 3655], '6Medhurst': [764], 'A.D.': [765], 'Jennings': [766], 'C.A.': [767], 'Robbins': [768, 3930], 'M.J.': [769], 'Davis': [770], 'R.P.': [771], 'Ellis': [772], 'Winborn': [774], 'K.Y.': [775], 'Lawrie': [776], 'K.W.': [777], 'Hervieu': [778], 'G.': [779, 781, 3841, 3869], 'Riley': [780], 'Bolaky': [782], 'J.E.': [783, 4523], 'Herrity': [784], 'N.C.': [785], 'Murdock': [786], 'Darker': [788], 'J.G.': [789], '2003;': [792, 918, 3124, 3518, 3719, 3900, 3947], '84:': [793], '1162-1172Crossref': [794], '(355)': [797], 'Scholar),': [799, 959, 2741, 2978, 3525], 'structure': [802], 'conserved': [809], 'among': [810], 'species,': [811], 'roles.': [816], 'Intravenous': [817, 1715], 'suggested': [821, 5281], 'rat': [826, 1030, 3032], '(5Reaux': [827, 2889, 3033, 3427, 3628], '7Lee': [857, 2919, 3063, 3457, 3658], 'D.K.': [858, 2920, 3064, 3458, 3659], 'Cheng': [859, 911, 2921, 3065, 3117, 3459, 3511, 3660, 3712], 'Fan': [863, 2925, 3069, 3463, 3664], 'Kariyawasam': [865, 2927, 3071, 3465, 3666], 'A.P.': [866, 948, 2928, 3072, 3466, 3667], 'Liu': [867, 2929, 3073, 3467, 3668], 'Osmond': [869, 2931, 3075, 3469, 3670], 'D.H.': [870, 2932, 3076, 3470, 3671], "O'Dowd": [873, 2935, 3079, 3473, 3674], '74:': [878, 2940, 3084, 3478, 3679], '34-41Crossref': [879, 2941, 3085, 3479, 3680], '(577)': [882, 2944, 3088, 3482, 3683], '8Tatemoto': [885, 3091, 3485, 3686], 'Takayama': [887, 3093, 3487, 3688, 4082, 4349], 'Kumaki': [891, 3097, 3491, 3692, 4086, 4353], 'Zhang': [893, 3099, 3493, 3694, 4088, 4355], 'W.': [894, 2958, 3100, 3494, 3695, 4089, 4356], 'Kumano': [895, 3101, 3495, 3696, 4090, 4357], 'Fujimiya': [897, 3103, 3497, 3698, 4092, 4359], 'Regul.': [899, 3105, 3499, 3700, 4094, 4361], 'Pept.': [900, 3106, 3500, 3701, 4095, 4362], '99:': [902, 3108, 3502, 3703, 4097, 4364], '87-92Crossref': [903, 3109, 3503, 3704, 4098, 4365], '(565)': [906, 3112, 3506, 3707, 4101, 4368], '9Cheng': [909, 3115, 3509, 3710], 'X.S.': [912, 3118, 3512, 3713], 'Pang': [913, 3119, 3513, 3714], 'C.C.': [914, 3120, 3514, 3715], 'Eur.': [915, 3121, 3515, 3716], 'Pharmacol.': [917, 951, 3123, 3517, 3718], '470:': [919, 3125, 3519, 3720], '171-175Crossref': [920, 3126, 3520, 3721], '(170)': [923, 3129, 3523, 3724], 'potently': [931], 'contracts': [932], 'saphenous': [934], 'vein': [935, 1816], 'smooth': [936, 2114], 'muscle': [937, 2115], 'vitro': [940, 1052, 3258], '(10Katugampola': [941], 'S.D.': [942], 'Maguire': [943], 'J.J.': [944], 'Matthewson': [945], 'Davenport': [947], 'Br.': [949], '132:': [953], '1255-1260Crossref': [954], '(187)': [957], 'indicating': [960, 2593], 'vasoconstrictor.': [966], 'Thus,': [967, 3752], 'at': [968, 1638, 1687, 1704, 1728, 1943, 1985, 2042, 2128, 2341, 2455, 2515, 2559, 3254, 4229, 4244, 4475, 4628], 'moment,': [970], 'controversial,': [980], 'it': [982, 2876, 3800, 5141, 5279], 'still': [984], 'unclear': [985], 'whether': [986, 2673, 2794, 3140, 4604, 4753], 'these': [987, 1211, 2660, 3141], 'actions': [988, 3142, 4896, 5085], 'really': [992, 3146, 3386], 'through': [993, 1814, 1998, 3147, 5292], 'because': [995], 'absence': [998], 'blocker': [1002], 'clarify': [1004, 4847, 4989], 'Therefore,': [1011, 4132], 'study,': [1014, 2640], 'animal': [1017, 3820, 5330], 'models': [1018, 3815, 3821], 'such': [1019], 'as': [1020, 1129, 1264, 1389, 1530, 1587, 2121, 2318, 2346, 2442, 3351, 3353, 3562, 3625, 3975, 4762, 4890, 5029, 5211], 'mice,': [1022, 1026, 1037, 2531, 5278], 'APJ/AT1a': [1023], 'knock-out': [1025, 1439, 5001], 'evaluated': [1039, 4878], 'functional': [1041], 'importance': [1042], 'apelin-APJ': [1044, 3410, 3806, 4148, 4413, 4605, 5288, 5308, 5342], 'signaling': [1045, 3411, 3807, 4149, 4414, 4606, 5289, 5343], 'vivo.': [1055], 'Targeting': [1057], 'Generation': [1059, 2447], 'Mutant': [1061], 'Mice—The': [1062, 1935], 'containing': [1065, 1983, 2034, 2095, 2229], 'locus': [1068], 'were': [1069, 1205, 1257, 1316, 1387, 1449, 1503, 1542, 1573, 1624, 1647, 1702, 1733, 1747, 1839, 1919, 2029, 2059, 2068, 2086, 2117, 2125, 2177, 2208, 2368, 2409, 2424, 2522, 2550, 2581, 2590, 2776, 3302, 3560, 3809, 4620], 'phage': [1073], 'library': [1074], 'C57BL/6': [1076], '(11Sugaya': [1078, 1392, 5032], 'Nishimatsu': [1080, 1394, 5034, 5362], 'Tanimoto': [1082, 1361, 1396, 5036], 'Takimoto': [1084, 1398, 1594, 5038], 'E.': [1085, 1399, 1595, 2954, 3925, 3999, 5039], 'Yamagishi': [1086, 1400, 5040], 'Imamura': [1088, 1402, 5042], 'Goto': [1090, 1404, 5044], 'Imaizumi': [1092, 1406, 5046], 'Hisada': [1094, 1408, 5048], 'Otsuka': [1096, 1410, 5050], 'Uchida': [1098, 1412, 5052], 'Sugiura': [1100, 1414, 5054], 'Fukuta': [1102, 1416, 5056], 'Fukamizu': [1104, 1373, 1418, 1549, 5058, 5365], 'Murakami': [1106, 1371, 1420, 1608, 5060], '1995;': [1111, 1380, 1425, 4869, 5065, 5170, 5199], '270:': [1112, 1426, 5066], '18719-18722Abstract': [1113, 1427, 5067], '(358)': [1121, 1435, 5075], 'Scholar)': [1123, 4103, 4370, 4876], 'cDNA': [1128], 'probe.': [1131], 'construct': [1133], 'targeting': [1135, 2464, 2490, 5243], 'vector': [1136, 2465], 'gene,': [1140, 2657], '156-bp': [1142], 'fragment': [1143, 1195, 1200, 1519], 'mouse': [1146, 1539, 2457, 2517, 4492], 'between': [1149, 2626], 'NcoI': [1151], 'site': [1152, 1164], 'translation': [1155], 'initiation': [1156], 'codon': [1157], 'Csp45I': [1163], 'replaced': [1166], 'nuclear': [1169, 1188], 'localization': [1170, 1189], 'signal-lacZ': [1171, 1190], 'cassette.': [1172], 'neomycin': [1174], 'phosphotransferase': [1175], '(neo)': [1176], 'cassette': [1178, 1225], 'derived': [1179, 3151, 4614, 5276], 'pMC1neoPolyA': [1181], '(Stratagene)': [1182], 'placed': [1184], 'downstream': [1185, 1209, 4508], 'gene.': [1191, 4835], '6.3-kb': [1193], 'XhoI/NcoI': [1194], '1.6-kb': [1198], 'Csp45I/Sau3AI': [1199], 'included': [1206], 'upstream': [1207], 'cassettes,': [1212], 'respectively': [1213], '(Fig.': [1214, 2499, 2570, 2750, 3324, 3343, 3423, 3621, 3748, 4293, 4316, 4812, 4981], '1A).': [1215, 2482], 'Details': [1216], 'negative': [1219], 'selection': [1220], 'diphtheria': [1223], 'toxin-A': [1224], 'described': [1227, 1265, 1390, 1543, 1588, 4214, 5030], 'elsewhere': [1228], '(12Yagi': [1229], 'Nada': [1231, 1273, 1333], 'Watanabe': [1233], 'Tamemoto': [1235], 'Kohmura': [1237], 'Ikawa': [1239, 1283, 1343], 'Aizawa': [1241, 1285, 1345], 'Anal.': [1243, 1287, 1347, 1489], '214:': [1246, 1290, 1350], '77-86Crossref': [1247], '(209)': [1250], 'TT2': [1254, 1300, 2486], 'ES': [1255, 1301, 1321], 'grown': [1258], 'on': [1259, 3393, 3783, 4072, 4480, 4720, 5086], 'embryonic': [1260, 2596], 'fibroblast': [1261], 'feeder': [1262], 'previously': [1266, 1391, 1544, 1589, 3627, 3796, 4215, 4877, 5031], '(13Yagi': [1267, 1327], 'Tokunaga': [1269, 1329], 'Furuta': [1271, 1331], 'Yoshida': [1275, 1335], 'Tsukada': [1277, 1337], 'Saga': [1279, 1339], 'Takeda': [1281, 1341], '70-76Crossref': [1291, 1351], '(425)': [1294, 1354], 'Homologous': [1297], 'recombination': [1298, 2493, 2514], 'detected': [1304, 2250, 2563], 'Southern': [1306, 2497, 2565], 'blotting': [1307, 2152, 2302, 2498], 'probe': [1309, 1534, 2761], '(687-bp': [1311], 'BanIII-Sau3AI': [1312], 'fragment).': [1313], 'Chimeric': [1314], 'injecting': [1319], 'into': [1323, 1626, 1749, 1759, 1963, 2031, 2524, 3604], 'ICR': [1324, 2525], '8-cell': [1325, 2526], 'embryos': [1326, 2527], '14Goto': [1357], 'Sugiyama': [1359, 1369, 1596], 'F.': [1360, 1597, 3871, 4001, 5191], 'Ishida': [1363], 'Syoji': [1365], 'Takahashi': [1367, 1600], 'Yagami': [1375, 1606], 'Lab.': [1377], 'Anim.': [1378], 'Sci.': [1379], '45:': [1381], '601-603PubMed': [1382], 'AT1a-deficient': [1385, 1461, 5011, 5018, 5088, 5111], 'Double': [1438], 'AT1a': [1444, 5006, 5103], 'study': [1448], 'heterozygous': [1452, 2548, 2629, 2664], 'after': [1454, 1710, 1865, 1878, 2134, 2415, 4233, 4247], 'crossing': [1456, 5008], 'single': [1458, 4156], 'RNA': [1463, 1469, 1502, 2670, 2766], 'Preparation': [1464, 1927], 'Northern': [1466, 2683], 'Blot': [1467], 'Analysis—Total': [1468], 'heart': [1474, 1564, 2687, 2692, 2812, 2851, 3349, 3832], 'four': [1478], 'independent': [1479, 2504], 'age-matched': [1480], 'ISOGEN': [1483], '(NipponGene)': [1484], '(15Chomczynski': [1485], 'Sacchi': [1487], '1987;': [1491], '162:': [1492], '156-159Crossref': [1493], '(63196)': [1496], 'Fifteen': [1499], 'micrograms': [1500], 'denatured': [1504], 'glyoxal,': [1506], 'separated': [1507], 'electrophoresis,': [1509], 'transferred': [1511, 2217], 'nylon': [1514, 2002], 'membrane.': [1515], '728-bp': [1517], 'NcoI/NaeI': [1518], 'corresponds': [1521], 'coding': [1524, 2474], 'regions': [1525], 'receptor-specific': [1533], '(probe': [1535], 'b).': [1536], 'Probes': [1537], 'glyceraldehyde-3-phosphate': [1540, 2759], 'dehydrogenase': [1541, 2760], '(16Miyagishi': [1545], 'Nakajima': [1547], 'Int.': [1551], 'Mol.': [1553], 'Med.': [1554], '5:': [1556], '27-31PubMed': [1557], 'Measurement': [1560, 2785], 'Blood': [1562, 2787], 'Pressure—The': [1563], 'rate': [1565, 2813, 2852, 3350], 'systolic,': [1567], 'mean,': [1568], 'diastolic': [1570], 'pressures': [1572], 'measured': [1574, 1698, 1788, 1862, 1906, 2334, 2369, 2806, 3552, 3581, 4777], 'programmable': [1577], 'sphygmomanometer': [1578], '(BP-200,': [1579], 'Softron,': [1580], 'Japan)': [1581], 'tail': [1584, 2568], 'cuff': [1585], 'method': [1586], '(17Fukamizu': [1590], 'Sugimura': [1592], 'Seo': [1598], 'M.S.': [1599], 'Hatae': [1602], 'Kajiwara': [1604], '268:': [1614], '11617-11621Abstract': [1615], 'Unanesthetized': [1622], 'introduced': [1625], 'holder': [1628], 'mounted': [1629], 'thermostatically': [1632], 'controlled': [1633], 'warning': [1634], 'plate': [1635], 'maintained': [1637, 1794], '37': [1639, 1986], '°C': [1640, 1987], 'during': [1641], 'measurement.': [1642], 'Intraperitoneal': [1643, 1830, 2326], 'Injection': [1644, 1716, 1831, 2327], 'Apelin—Experiments': [1646], 'performed': [1648, 1840, 1896, 2682, 4770], '4-month-old': [1650, 1842], 'male': [1651, 1843, 1941, 3300], 'under': [1653, 1845, 2139, 2814, 3417, 4340], 'conscious': [1655, 1847, 2336], 'unrestrained': [1657, 1849, 2338], 'conditions.': [1658, 1850, 2142], '[Pyr1]Apelin-13': [1659, 1805], '(Peptide': [1660], 'Institute': [1661], '4361-v)': [1662], 'suspended': [1664, 1854], 'saline': [1666, 1811, 1893], '(0.9%': [1667], 'NaCl': [1668], 'distilled': [1670], 'water).': [1671], 'After': [1672, 2223, 2275, 2376, 2483, 4154], 'measurement': [1674], 'basal': [1677, 2350], 'systolic': [1678, 1694, 1902, 1911, 2351, 2808, 2836, 3318, 3337, 4167, 4205, 4220, 4261, 4284, 4298, 4779, 4806, 4943], 'pressure,': [1680], '[Pyr1]apelin-13': [1681, 1887, 2185], 'administered': [1683, 1813, 3133, 3541], 'intraperitoneal': [1685, 1867, 1898, 2359, 4157, 4788, 4948], 'injection': [1686, 1797, 1868, 1899, 2360, 3332, 4159, 4251, 4311, 4338, 4789, 4949], '285': [1688], 'μg/kg': [1689, 1889], 'body': [1690, 1873, 1890, 4162], 'weight': [1691], 'continuously.': [1699, 1789, 1907], 'data': [1701, 2423, 5127], 'calculated': [1703, 1920], '5-min': [1705], 'intervals': [1706], '20': [1708, 1971, 2007], 'min': [1709, 1877, 1990, 2414, 4232, 4246], 'apelin.': [1714, 1926], 'Apelin': [1718, 1833, 3149, 3400, 4076], 'Wistar-Kyoto': [1720], '(WKY)': [1721], 'Rat': [1722], 'SHR—SHR': [1724], 'WKY': [1726, 3558, 3576, 3607, 3777, 4036], 'rats': [1727, 3426, 3559, 3577, 4037, 4399], '12': [1729, 2035], 'weeks': [1730, 1945], 'age': [1732, 1947, 2345], 'anesthetized': [1734], 'sodium': [1736], 'pentobarbital': [1737, 1801], '(35': [1738], 'mg/kg': [1739, 1800, 1872, 4161], 'intraperitoneal).': [1740], 'PE-10': [1741], 'catheters': [1742], '(Clay': [1743], 'Adams,': [1744], 'Parsippany,': [1745], 'NJ)': [1746], 'inserted': [1748], 'right': [1751, 1761, 2572], 'femoral': [1752, 1762], 'artery': [1753], 'measuring': [1755], 'vain': [1763], 'allowing': [1765], '[Pyr1]apelin-13.': [1769], 'arterial': [1771, 3555, 3616, 3741], 'catheter': [1772, 1817], 'connected': [1774], 'transducer': [1778], '(TP-200T,': [1779], 'Nihon': [1780], 'Kohden,': [1781], 'Tokyo,': [1782], 'Japan),': [1783], 'anesthetic': [1791], 'level': [1792], 'subcutaneous': [1796], '10': [1799, 1821, 2503, 4231, 4954, 4975], 'every': [1802], '40': [1803, 2413], 'min.': [1804, 2048], 'dissolved': [1806], '0.1': [1808], 'ml': [1809, 1972, 2008, 2020, 2025, 2036, 2050, 2064, 2090], '(2,': [1818], '4,': [1819], 'nmol/kg).': [1822], 'Pretreatment': [1823], 'NG-Nitro-l-Arginine': [1825], 'Methyl': [1826], 'Ester': [1827], '(l-NAME)': [1828], 'Wild-type': [1835, 1932], 'Mice—Experiments': [1838], 'l-NAME': [1851, 1870, 4212, 4248, 4292, 4314, 4327], '(Sigma)': [1852], 'saline.': [1856], 'Systolic': [1857], 'continuously': [1861, 2411, 3553, 4926], 'before': [1863], 'acute': [1866, 3308, 4256], '(10': [1871, 2186, 2364, 4160, 4796], 'weight).': [1874], 'At': [1875], '15': [1876, 2047, 4245], 'additional': [1884], '(285': [1888], 'weight)': [1891, 4163], 'or': [1892, 2188, 2630], 'alone': [1894], 'maxima': [1909], 'responses': [1914, 2357, 2399], 'injections': [1916], '0–5': [1923], 'min-post-injection': [1924], 'Endothelial': [1929, 2165, 4429], 'Cells': [1930, 4430], '11': [1944], 'perfused': [1949], '0.25%': [1951, 1959], 'heparin/phosphate-buffered': [1952, 1960], 'saline(-)': [1953], 'removed': [1955], 'aseptically,': [1956], 'rinsed': [1957], 'saline(-),': [1961], 'minced': [1962], '∼1': [1964], '×': [1965, 2044], '2-mm': [1966], 'squares,': [1967], 'digested': [1969], 'collagenase': [1974], 'type': [1975], 'I': [1976], '(4': [1977], 'mg/ml,': [1978], 'Worthington)': [1979], 'serum-free': [1981, 2010, 2022, 2066], 'DMEM': [1982, 2067], 'antibiotic': [1984], '60': [1989], 'shaking.': [1992], 'cellular': [1994], 'digest': [1995], 'filtered': [1997], 'sterile': [2000], '40-μm': [2001], 'mesh': [2003], 'washed': [2005], 'cell': [2014, 2027, 2102, 2206, 2505], 'pellet': [2015], 'resuspended': [2017, 2087], '4': [2019, 2089, 2342, 3584], 'DMEM.': [2023], '2': [2024, 2049, 2063, 3593, 4883], 'suspension': [2028], 'put': [2030], 'tube': [2033], '30%': [2038], 'Percoll': [2039, 2073], 'centrifuged': [2041], '800': [2043], 'g': [2045], 'concentrated': [2053], 'fraction': [2054], 'recovered': [2060], 'added,': [2069], 'then': [2071, 2085, 2216, 4925], 'density': [2074], 'gradient': [2075], 'centrifugation': [2076], 'carried': [2078], 'out': [2079], 'again.': [2080], 'collected': [2082], 'growth': [2092, 2103, 4464], 'medium': [2093], '(DMEM': [2094], '10%': [2096], 'fetal': [2097, 2189], 'serum': [2099, 2191, 2257, 4659], 'supplement': [2104], 'neural': [2107], 'tissue': [2108], '(Sigma))': [2109], 'culture.': [2111], 'Contaminated': [2112], 'vascular': [2113, 4130, 4444], 'stripped': [2118], 'off': [2119], 'physically': [2120], 'necessary.': [2122], 'Confluent': [2123], 'passed': [2126], 'routinely': [2127], 'split': [2130], 'ratio': [2131], '1–3': [2133], 'trypsin/EDTA': [2135], 'digestion': [2136], 'cultured': [2138, 2178], 'same': [2141, 2296, 4275], 'We': [2143, 3132, 4836, 4903, 5358], 'ascertained': [2144], 'purity': [2146], 'Western': [2151, 2261, 2301], 'monoclonal': [2154, 2305], 'anti-mouse': [2155], 'CD-31': [2156], 'antibody': [2157, 2242, 2248, 2307], '(BD': [2158, 2308], 'Biosciences)': [2159, 2259], '(data': [2160, 2634, 3007, 3358, 4235], 'shown).': [2162, 2636, 3009, 3360, 4237], 'Detection': [2163], 'Synthase': [2167, 4070], '(eNOS)': [2168], 'Phosphorylation—Isolated': [2169], '6-well': [2180], 'plates': [2181], 'stimulated': [2183, 4621], 'μm)': [2187], '(10%)': [2192], '5': [2194], 'min,': [2195], 'terminated': [2200], 'adding': [2202], 'Laemmli': [2203], 'buffer.': [2204], 'lysates': [2207], 'subjected': [2209, 2299], 'SDS/7.5%': [2211], 'polyacrylamide': [2212], 'gel': [2213], 'electrophoresis': [2214], 'polyvinylidene': [2219], 'difluoride': [2220], 'membrane': [2221, 2233, 2297], '(Millipore).': [2222], 'blocking': [2224, 2227], 'buffer': [2228, 2280], '5%': [2230], 'milk,': [2231], 'incubated': [2235], 'polyclonal': [2238], 'anti-human': [2239], 'phospho-eNOS': [2240], '(Ser1177)': [2241], '(Cell': [2243], 'Signaling': [2244], 'Technology)': [2245], 'bound': [2247], 'horseradish': [2252], 'peroxydase-labeled': [2253], 'donkey': [2254], 'anti-(rabbit': [2255], 'IgG)': [2256], '(Amersham': [2258], 'Lightning': [2262], 'Plus': [2263], 'chemiluminescence': [2264], 'reagents': [2265], '(Perkin-Elmer': [2266], 'Life': [2267], 'Sciences)': [2268], 'measure': [2270], 'eNOS.': [2274], 'washing': [2276], 'reprobing': [2279], 'composition': [2283], '(62.5': [2284], 'mm': [2285, 2290, 2846, 3585, 3594, 4180, 4191, 5120], 'Tris-HCl': [2286], '(pH': [2287], '6.7),': [2288], '100': [2289], 'β-mercaptoethanol,': [2291], '2%': [2293], 'SDS),': [2294], 'anti-eNOS': [2306], 'Transduction': [2309], 'Laboratories)': [2310], 'detect': [2312], 'expression': [2314], 'levels': [2315], 'eNOS': [2317, 4121, 4426, 4435, 4450, 4470, 4483, 4497, 4518, 4627, 4638, 4645, 4670, 4699, 5298], 'internal': [2320], 'control.': [2321, 3564], 'Treatment': [2322], 'Captopril': [2324], 'Angiotensin': [2329, 4732], 'II—Systolic': [2330], 'female': [2339], 'months': [2343], 'mentioned': [2347], 'above.': [2348], 'II': [2363, 2402, 4774, 4795, 4844, 4923, 4952, 4972], '30': [2366, 4798], 'μg/kg)': [2367, 2408, 4799, 4976], 'prior': [2370], 'captopril.': [2375], 'captopril': [2380, 4899], '(500': [2381], 'mg/liter': [2382], 'drinking': [2384, 2887], 'water)': [2385], 'week': [2388, 4915], 'inhibit': [2390], 'production': [2393, 4049, 4919], 'given': [2403], 'lower': [2405, 3738, 4928, 5136], 'dose': [2406, 4276, 4970, 5154], '(3–30': [2407], 'recorded': [2410], 'Statistical': [2421], 'Analysis—The': [2422], 'analyzed': [2425, 2756], "Student's": [2427], 't': [2428], 'test': [2429, 4752], 'unpaired': [2431], 'values.': [2432], 'p': [2433, 5123], '<': [2434, 5124], '0.05': [2435], 'considered': [2437], 'significant.': [2438], 'Results': [2439], 'means': [2444], '±': [2445, 2840, 2844, 2854, 2858, 3583, 3592, 4174, 4178, 4185, 4189, 5114, 5118], 'S.E.': [2446], 'Mice—To': [2450], 'generate': [2451, 2529], 'null': [2453], 'mutation': [2454, 2558], 'locus,': [2460], 'designed': [2462], 'would': [2467], 'replace': [2468], 'portion': [2470], 'region': [2475], 'promoterless': [2478], 'lacZ': [2479], '(Fig,': [2481], 'electroporation': [2484], 'vector,': [2491], 'homologous': [2492, 2513, 2582], 'confirmed': [2495], '1B,': [2500, 2571], 'left': [2501], 'panel).': [2502, 2573], 'lines': [2506], '195': [2508], 'G418-resistant': [2509], 'had': [2511, 2745], 'undergone': [2512], 'locus.': [2519], 'Eight': [2520], 'clones': [2521, 2534], 'injected': [2523, 3304, 3603, 4240, 4927], 'chimeric': [2530], 'two': [2533], 'gave': [2535], 'rise': [2536], 'germ': [2538], 'line': [2539], 'transmission': [2540], 'backcross': [2542], 'mating': [2543], 'C57BL/6J': [2545], 'intercrossed': [2551, 2661], 'produce': [2553], 'offspring,': [2555], 'loci': [2561], 'analysis': [2566, 2685], 'Of': [2574], '396': [2576], 'offspring': [2577], 'analyzed,': [2578], '76': [2579], '(19%)': [2580], 'disrupted': [2585], 'allele': [2586], '103': [2588], '(26%)': [2589], 'wild': [2591], 'type,': [2592], 'normal': [2595, 4748, 5345], 'development': [2597], 'histological': [2604], 'sections': [2605], 'heart,': [2607], 'lung,': [2608], 'kidney,': [2609], 'spleen,': [2610], 'brain,': [2611], 'ovary,': [2612], 'skeletal': [2613], 'muscle,': [2614], 'liver,': [2615], 'white': [2617], 'adipose': [2618], 'did': [2619, 2828], 'reveal': [2621], 'any': [2622, 2831], 'differences': [2623, 4043], 'morphology': [2625], 'following': [2639], 'gain': [2642], 'effects': [2645, 3780, 4031, 4136, 5306], 'backgrounds': [2649], 'exception': [2652], 'littermates': [2662, 3001, 4980], 'further': [2667], 'experiments.': [2669], 'Analysis—To': [2671], 'determine': [2672, 4603], 'message': [2675, 2749], 'present': [2677], 'mutants,': [2680], 'blot': [2684, 2754], 'RNA.': [2690], 'Although': [2691], 'express': [2696], 'rodents': [2701], 'no': [2746, 3334, 4281], 'detectable': [2747], '1C).': [2751], 'duplicate': [2753], 'confirm': [2763], 'sample': [2767], 'intact.': [2769], 'indicated': [2772, 5128, 5244], 'transcripts': [2775], 'absent': [2777], 'completely': [2778], '(APJ-deficient': [2783], 'mice).': [2784], 'Pressure': [2788], 'Administration': [2790, 3398], 'Apelin—To': [2792], 'ascertain': [2793, 3139], 'APJ-mediated': [2795, 4059, 4342], 'pathways': [2796, 3412, 3808], 'participate': [2797], 'As': [2818, 4640, 5013], 'shown': [2819, 4641, 5014], 'Fig.': [2821, 4643, 5016], '2A,': [2822], 'show': [2830], 'difference': [2832], '(106.7': [2839], '2.0': [2841], '105.9': [2843], '2.5': [2845, 4190], 'Hg,': [2847, 3586, 3595, 5121], 'respectively)': [2848], '(632.0': [2853], '19.2': [2855], '616.1': [2857], '32.8': [2859], 'cpm,': [2860], 'respectively),': [2861], 'Furthermore,': [2875], 'reported': [2878, 3013, 3248, 3626, 3804, 4448], 'concerned': [2882], 'behavior': [2888], '18Taheri': [2947], 'Murphy': [2949], 'Cohen': [2951], 'Sujkovic': [2953], 'Dhillo': [2957], 'Dakin': [2959], 'Sajedi': [2961], 'Ghatei': [2963], 'Bloom': [2965], '2002;': [2971, 3860, 4013], '291:': [2972], '1208-1212Crossref': [2973], '(279)': [2976], 'volume': [2981], 'water': [2983, 3003], 'intake': [2984], 'concentration': [2987, 4384, 4393], 'urinary': [2989], 'electrolytes': [2990], 'distinguishable': [2996], 'those': [2998], 'when': [3002], 'freely': [3005], 'available': [3006], 'It': [3010, 4446], 'been': [3012, 3247, 3794, 3802], 'systemic': [3022, 3367, 3758, 4375, 4772, 5305], '77-amino': [3154], 'precursor': [3156], 'processed': [3158], 'isoforms': [3161], 'deleting': [3163], 'terminus': [3166], 'pyroglutamylated': [3241], 'form': [3242], 'apelin-13,': [3244], '[pGlu]apelin-13,': [3245], 'effective': [3252], 'activity': [3253], 'Conscious': [3299], 'intraperitoneally': [3303], '[pGlu]apelin-13.': [3306], '2B).': [3325], 'revealed': [3333, 4940, 4963], 'change': [3335, 3347, 4282], '2C)': [3344], 'without': [3345], 'well': [3352], 'clearly': [3363], 'lowers': [3371, 3413], 'responsible': [3387, 5249], 'regulation.': [3397, 4723, 4854], 'Spontaneously': [3402], 'Hypertensive': [3403], 'Rat—Given': [3404], 'activation': [3407, 4111, 4519], 'state': [3420, 4825], '2B)': [3424], 'also': [3530, 4371], 'evoked': [3531, 3763], 'conditions?': [3535], 'address': [3537], 'question,': [3539], 'intravenously': [3543], 'chronic': [3546, 3823, 3831], 'Before': [3565], 'mean': [3572, 3615, 3740], 'SHR': [3579, 3733, 4033], '(77': [3582], 'n': [3587, 3596], '=': [3588, 3597, 4199], '10,': [3589], '117': [3591], '9,': [3598], 'respectively).': [3599], 'When': [3600], 'normotensive': [3606], 'rats,': [3608, 4386], 'dose-dependent': [3610, 3746], 'significant': [3612, 4965], 'decrease': [3613, 4259], 'elicited': [3620], '2D,': [3622, 3749], 'closed': [3623, 4295], 'bar)': [3624, 4662], 'intravenous': [3728], 'found': [3735], 'manner': [3747], 'open': [3750], 'bar).': [3751, 4296, 4668, 4689], 'animals,': [3766], 'degree': [3769], 'decrement': [3771], 'less': [3773], 'than': [3774], 'rats.': [3778], 'animals': [3791], 'explored': [3795], 'date,': [3798], 'although': [3799], 'recently': [3803], 'down-regulated': [3810], 'mechanical': [3813, 4468], 'stretch': [3814], 'vitro,': [3817], 'ventricular': [3824], 'overload,': [3826], 'patients': [3829], 'failure': [3833], '(19Szokodi': [3836], 'Tavi': [3838], 'Foldes': [3840], 'Voutilainen-Myllyla': [3842], 'Ilves': [3844, 3876], 'Tokola': [3846], 'Pikkarainen': [3848], 'Piuhola': [3850], 'Rysa': [3852], 'Toth': [3854, 3894], 'Ruskoaho': [3856, 3892], 'Circ.': [3858], '91:': [3861], '434-440Crossref': [3862], '(529)': [3865], '20Foldes': [3868], 'Horkay': [3870], 'Szokodi': [3872], 'Vuolteenaho': [3874], 'Lindstedt': [3878], 'K.A.': [3879], 'Mayranpaa': [3880], 'Sarman': [3882], 'B.': [3883, 3923, 4586], 'Seres': [3884], 'L.': [3885, 3935, 3989, 4859, 5160], 'Skoumal': [3886], 'Lako-Futo': [3888], 'deChatel': [3890], '308:': [3901], '480-485Crossref': [3902], '(224)': [3905], '21Chen': [3908], 'M.M.': [3909], 'Ashley': [3910], 'E.A.': [3911], 'Deng': [3912, 3916], 'D.X.': [3913], 'Tsalenko': [3914], 'Tabibiazar': [3918], 'Ben-Dor': [3920], 'Fenster': [3922], 'Yang': [3924], 'King': [3926], 'J.Y.': [3927], 'Fowler': [3928], 'Johnson': [3932], 'F.L.': [3933], 'Bruhn': [3934], 'McDonagh': [3936], 'Dargie': [3938], 'Yakhini': [3940], 'Tsao': [3942], 'P.S.': [3943], 'Quertermous': [3944], 'Circulation.': [3946], '108:': [3948], '1432-1439Crossref': [3949], '(291)': [3952], 'angiotensin-converting': [3958, 4911], 'enzyme-related': [3959], 'carboxypeptidase': [3960], '(ACE2),': [3961], 'zinc': [3963], 'metalloprotease': [3964], 'whose': [3965], 'closest': [3966], 'homolog': [3967], 'I-converting': [3971], 'enzyme,': [3972, 4912], 'breakdown': [3977], 'enzyme': [3978], 'peptides': [3981], '(22Vickers': [3982], 'Hales': [3984], 'Kaushik': [3986], 'V.': [3987], 'Dick': [3988], 'Gavin': [3990], 'Tang': [3992], 'Godbout': [3994], 'Parsons': [3996], 'Baronas': [3998], 'Hsieh': [4000], 'Acton': [4002], 'Patane': [4004], 'Nichols': [4006], 'Tummino': [4008], '277:': [4014], '14838-14843Abstract': [4015], '(1144)': [4023], 'reduction': [4027], 'might': [4038], 'be': [4039, 5327, 5333], 'attributed': [4040], 'balance': [4046], 'degradation': [4051], 'sensitivity': [4057, 4967, 5151], 'intracellular': [4060], 'signalings': [4061], 'desensitization.': [4064], 'Effects': [4065], 'Nitric': [4068], 'Oxide': [4069], 'Inhibitor': [4071], 'Action': [4074, 4730], 'Administration—Tatemoto': [4077], 'et': [4078, 4345, 4856], 'al.': [4079, 4346, 4857], '(8Tatemoto': [4080, 4347], 'suggest': [4104], 'causes': [4107], 'vasodilatation': [4108], 'via': [4109], 'oxide': [4115], '(NO)/l-arginine': [4116], 'tone.': [4131, 4445], 'examined': [4134], 'depressor': [4145, 4410], 'observed': [4150, 4332, 4396], 'bolus': [4158], 'similarly': [4171], '111.0': [4173], '2.2': [4175], '142.3': [4177], '2.9': [4179], 'Hg': [4181, 4192], '108.1': [4184], '2.4': [4186], '142.4': [4188], '(n': [4198], '7–8/group),': [4200], 'respectively.': [4201], 'increase': [4203, 4389, 4804, 5149], 'rat,': [4217], 'each': [4224, 4744], 'group': [4225], 'reached': [4226], 'plateau': [4228], 'around': [4230], 'Accordingly,': [4238], 'administration.': [4249], 'induced': [4254, 5286], 'transient': [4258], 'non-treated': [4266, 4665], 'contrast,': [4270], 'caused': [4279], 'almost': [4280], 'pretreated': [4290, 4400, 4904], '3A,': [4294, 4317], 'changed': [4306], 'regardless': [4312], 'opened': [4318], 'bar),': [4319], 'suppressive': [4323], 'point': [4325], 'exists': [4339], 'signalings.': [4343], 'Tatemoto': [4344], 'report': [4372, 4694], 'plasma': [4382], 'NOx': [4383, 4392], 'whereas': [4387], 'l-NAME.': [4402], 'findings': [4404], 'provided': [4405], 'possibility': [4407], 'result': [4417], 'stimulation': [4419, 4660, 4675], 'production.': [4423], 'Apelin-mediated': [4424], 'Ser1176': [4425, 4629, 4671], 'Phosphorylation': [4427], 'Mice—NO': [4432], 'produced': [4433], 'crucial': [4438], 'activated': [4452, 4472, 4656, 5296], 'pathophysiological': [4459, 5347], 'stimuli,': [4460], 'hormones': [4462], 'factors,': [4465], 'stimuli.': [4469], 'Ser1177': [4477], 'residue': [4478, 4630], '(based': [4479], 'eNOS-Ser1179': [4490], 'eNOS-Ser1176),': [4493], 'best': [4495], 'characterized': [4496], 'site,': [4499], 'phosphorylated': [4502], 'kinase': [4505], 'Akt,': [4506], 'mediator': [4509], 'phosphatidylinositol': [4511], '3-kinase,': [4512], 'greatly': [4514], 'contributes': [4515], '(23Michell': [4520], 'B.J.': [4521], 'Griffiths': [4522], 'Mitchelhill': [4524], 'K.I.': [4525], 'Rodriguez-Crespo': [4526], 'Tiganis': [4528], 'Bozinovski': [4530], 'de': [4532], 'Montellano': [4533], 'P.R.': [4534], 'Kemp': [4535], 'B.E.': [4536], 'Pearson': [4537], 'R.B.': [4538], 'Curr.': [4539], '1999;': [4541, 4573, 4594], '9:': [4542], '845-848Abstract': [4543], '(412)': [4551], '24Fulton': [4554], 'D.': [4555], 'Gratton': [4556], 'J.P.': [4557], 'McCabe': [4558], 'T.J.': [4559], 'Fontana': [4560], 'Fujio': [4562], 'Walsh': [4564], 'Franke': [4566], 'T.F.': [4567], 'Papapetropoulos': [4568], 'Sessa': [4570], 'W.C.': [4571], 'Nature.': [4572, 4593, 4868, 5169, 5198], '399:': [4574, 4595], '597-601Crossref': [4575], '(2233)': [4578], '25Dimmeler': [4581], 'Fleming': [4583], 'Fisslthaler': [4585], 'Hermann': [4587], 'Busse': [4589], 'Zeiher': [4591], 'A.M.': [4592], '601-605Crossref': [4596], '(3047)': [4599], 'can': [4607, 4697], 'actually': [4608], 'activate': [4609, 4698], 'assessed': [4632], 'state-specific': [4637], 'antibody.': [4639], '3B,': [4644], '(gray': [4661], '(open': [4667], 'Interestingly,': [4669], 'promoted': [4677], '(closed': [4688], 'first': [4693], 'critical': [4708], 'potentializes': [4716], 'Association': [4724], 'Mouse': [4726], 'Pressor': [4729], 'II—In': [4733], 'regulation,': [4736], 'vasoconstriction': [4738, 5224], 'vasorelaxation': [4740, 5216], 'constantly': [4742], 'antagonized': [4743], 'maintain': [4747], 'component': [4765, 4893], 'actions,': [4768], 'pharmacological': [4791], 'doses': [4792, 4932], 'resulted': [4800], 'similar': [4803], 'groups': [4811], '3A),': [4813], 'mediated': [4819, 5291], 'affected': [4828], 'disruption': [4831], 'next': [4837], 'different': [4840], 'protocol': [4841], 'function': [4850, 5210], 'Hein': [4855], '(26Hein': [4858, 5159], 'Barsh': [4860, 5161], 'G.S.': [4861, 5162], 'Pratt': [4862, 5163], 'R.E.': [4863, 5164], 'Dzau': [4864, 5165], 'V.J.': [4865, 5166], 'Kobilka': [4866, 5167], 'B.K.': [4867, 5168], '377:': [4870, 5171, 5200], '744-747Crossref': [4871, 5172], '(696)': [4874, 5175], '(AT2)': [4885], 'administrating': [4898], 'AT2-deficient': [4901, 5145], 'captopril,': [4907], 'inhibitor': [4909], 'block': [4917], 'more': [4930], 'captopril-treated': [4937, 4960], '(above': [4953], 'μg/kg).': [4955], 'contrary,': [4958], 'low': [4969, 5153], '(3': [4973], '4A,': [4982], 'captopril).': [4983], 'making': [4985], 'another': 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