Publication Information

{'id': 'https://openalex.org/W2117158095', 'doi': 'https://doi.org/10.18632/oncotarget.1169', 'title': 'A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity', 'display_name': 'A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity', 'publication_year': 2013, 'publication_date': '2013-07-30', 'ids': {'openalex': 'https://openalex.org/W2117158095', 'doi': 'https://doi.org/10.18632/oncotarget.1169', 'mag': '2117158095', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24583601', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3996659'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1169', 'pdf_url': 'https://www.oncotarget.com/article/1169/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.oncotarget.com/article/1169/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048905023', 'display_name': 'Matthew P. Ablett', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Matthew P. Ablett', 'raw_affiliation_strings': ['Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK'], 'affiliations': [{'raw_affiliation_string': 'Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028638789', 'display_name': 'Ciara O’Brien', 'orcid': 'https://orcid.org/0000-0002-3769-1883'}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ciara S. O’Brien', 'raw_affiliation_strings': ['Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK'], 'affiliations': [{'raw_affiliation_string': 'Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047364768', 'display_name': 'Andrew H. Sims', 'orcid': 'https://orcid.org/0000-0001-9082-3665'}, 'institutions': [{'id': 'https://openalex.org/I2802581871', 'display_name': 'Edinburgh Cancer Research', 'ror': 'https://ror.org/05a7t9b67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I2802581871', 'https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Andrew H. Sims', 'raw_affiliation_strings': ['Applied Bioinformatics of Cancer, Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh, EH4 2XU, UK'], 'affiliations': [{'raw_affiliation_string': 'Applied Bioinformatics of Cancer, Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh, EH4 2XU, UK', 'institution_ids': ['https://openalex.org/I2802581871']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091730831', 'display_name': 'Gillian Farnie', 'orcid': 'https://orcid.org/0000-0002-1407-2529'}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gillian Farnie', 'raw_affiliation_strings': ['Cancer Stem Cell Research, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK'], 'affiliations': [{'raw_affiliation_string': 'Cancer Stem Cell Research, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I28407311']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073495103', 'display_name': 'Robert B. Clarke', 'orcid': 'https://orcid.org/0000-0001-5407-3123'}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}, {'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Robert B. Clarke', 'raw_affiliation_strings': ['Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK'], 'affiliations': [{'raw_affiliation_string': 'Breast Biology Group, Institute of Cancer Sciences, Paterson Building, University of Manchester, Wilmslow Road, Manchester,M20 4BX,UK', 'institution_ids': ['https://openalex.org/I28407311', 'https://openalex.org/I4210129527']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5073495103'], 'corresponding_institution_ids': ['https://openalex.org/I28407311', 'https://openalex.org/I4210129527'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.082, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.999952, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '5', 'issue': '3', 'first_page': '599', 'last_page': '612'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/skbr3', 'display_name': 'SKBR3', 'score': 0.72055364}, {'id': 'https://openalex.org/keywords/matrigel', 'display_name': 'Matrigel', 'score': 0.51301616}], 'concepts': [{'id': 'https://openalex.org/C191560914', 'wikidata': 'https://www.wikidata.org/wiki/Q7390592', 'display_name': 'SKBR3', 'level': 5, 'score': 0.72055364}, {'id': 'https://openalex.org/C129470790', 'wikidata': 'https://www.wikidata.org/wiki/Q415718', 'display_name': 'CXCR4', 'level': 4, 'score': 0.68965757}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.63286334}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.6076361}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.56928873}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.54979336}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.52682537}, {'id': 'https://openalex.org/C2778608917', 'wikidata': 'https://www.wikidata.org/wiki/Q6787805', 'display_name': 'Matrigel', 'level': 3, 'score': 0.51301616}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43455458}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39523655}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3641608}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.36144686}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.33075362}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.26657295}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2640934}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.19840357}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.18071005}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.12361094}, {'id': 'https://openalex.org/C2994423619', 'wikidata': 'https://www.wikidata.org/wiki/Q9103', 'display_name': 'Human breast', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D019718', 'descriptor_name': 'Receptors, CXCR4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D023102', 'descriptor_name': 'Anoikis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023102', 'descriptor_name': 'Anoikis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001596', 'descriptor_name': 'Benzylamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000080027', 'descriptor_name': 'Cyclams', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006571', 'descriptor_name': 'Heterocyclic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006571', 'descriptor_name': 'Heterocyclic Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019718', 'descriptor_name': 'Receptors, CXCR4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019718', 'descriptor_name': 'Receptors, CXCR4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019718', 'descriptor_name': 'Receptors, CXCR4', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1169', 'pdf_url': 'https://www.oncotarget.com/article/1169/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3996659', 'pdf_url': 'https://europepmc.org/articles/pmc3996659?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996659', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1169&path%5B%5D=1456', 'pdf_url': 'http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1169&path%5B%5D=1456', 'source': {'id': 'https://openalex.org/S4306400662', 'display_name': 'Research Explorer (The University of Manchester)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I28407311', 'host_organization_name': 'University of Manchester', 'host_organization_lineage': ['https://openalex.org/I28407311'], 'host_organization_lineage_names': ['University of Manchester'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24583601', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1169', 'pdf_url': 'https://www.oncotarget.com/article/1169/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.46}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1698416416', 'https://openalex.org/W1816419917', 'https://openalex.org/W1968952693', 'https://openalex.org/W1973968998', 'https://openalex.org/W1979440527', 'https://openalex.org/W1980050427', 'https://openalex.org/W1980541088', 'https://openalex.org/W1983798380', 'https://openalex.org/W1993700321', 'https://openalex.org/W1997280228', 'https://openalex.org/W1998211868', 'https://openalex.org/W1999997314', 'https://openalex.org/W2010867675', 'https://openalex.org/W2022881840', 'https://openalex.org/W2023427658', 'https://openalex.org/W2034320146', 'https://openalex.org/W2038937310', 'https://openalex.org/W2039169692', 'https://openalex.org/W2041232976', 'https://openalex.org/W2047655419', 'https://openalex.org/W2049638120', 'https://openalex.org/W2050300062', 'https://openalex.org/W2055498399', 'https://openalex.org/W2063632352', 'https://openalex.org/W2072178451', 'https://openalex.org/W2082161467', 'https://openalex.org/W2086828029', 'https://openalex.org/W2091647214', 'https://openalex.org/W2099764429', 'https://openalex.org/W2101885447', 'https://openalex.org/W2102790879', 'https://openalex.org/W2109972881', 'https://openalex.org/W2115235864', 'https://openalex.org/W2115504447', 'https://openalex.org/W2116018770', 'https://openalex.org/W2118397294', 'https://openalex.org/W2128215113', 'https://openalex.org/W2130966806', 'https://openalex.org/W2131170195', 'https://openalex.org/W2133985933', 'https://openalex.org/W2135827569', 'https://openalex.org/W2156140889', 'https://openalex.org/W2156323704', 'https://openalex.org/W2159640574', 'https://openalex.org/W2161199652', 'https://openalex.org/W2171581347', 'https://openalex.org/W2171687293', 'https://openalex.org/W2762697978', 'https://openalex.org/W84525201'], 'related_works': ['https://openalex.org/W4386019298', 'https://openalex.org/W3030284990', 'https://openalex.org/W3029688989', 'https://openalex.org/W2563850085', 'https://openalex.org/W2391546368', 'https://openalex.org/W2382249802', 'https://openalex.org/W2371886889', 'https://openalex.org/W2364758432', 'https://openalex.org/W2314009882', 'https://openalex.org/W2030161097'], 'abstract_inverted_index': {'//': [0, 82], 'Matthew': [1], 'P.': [2], 'Ablett': [3], '1': [4, 9, 23, 24], ',': [5, 10, 15], 'Ciara': [6], 'S.': [7], "O'Brien": [8], 'Andrew': [11], 'H.': [12], 'Sims': [13], '3': [14, 59], 'Gillian': [16], 'Farnie': [17], '2': [18, 41], 'and': [19, 71, 121, 140, 151, 171, 179, 219, 225, 242, 289, 388, 407], 'Robert': [20, 79], 'B.': [21], 'Clarke': [22], 'Breast': [25], 'Biology': [26], 'Group,': [27], 'Institute': [28, 46, 68], 'of': [29, 35, 47, 53, 62, 69, 138, 207, 277, 307, 418], 'Cancer': [30, 42, 48, 65], 'Sciences,': [31, 49], 'Paterson': [32, 50], 'Building,': [33, 51], 'University': [34, 52], 'Manchester,': [36, 54], 'Wilmslow': [37, 55], 'Road,': [38, 56, 75], 'Manchester,M20': [39, 57], '4BX,UK': [40], 'Stem': [43], 'Cell': [44], 'Research,': [45], '4BX,UK.': [58], 'Applied': [60], 'Bioinformatics': [61], 'Cancer,': [63], 'Edinburgh': [64], 'Research': [66], 'Centre,': [67], 'Genetics': [70], 'Molecular': [72], 'Medicine,': [73], 'Crewe': [74], 'Edinburgh,EH4': [76], '2XU,UK.': [77], 'Correspondence:': [78], 'Clarke,': [80], 'email:': [81], 'Keywords': [83], ':': [84, 94, 99, 104], 'CXCR4,': [85], 'stem': [86, 124, 154, 182, 255, 299, 391, 404], 'cells,': [87], 'breast': [88, 127, 153, 176, 262, 280, 291, 310, 390, 402], 'cancer,': [89, 128], 'mammospheres,': [90], 'AMD3100,': [91], 'SDF-1': [92, 274], 'Received': [93], 'July': [95, 100, 105], '10,': [96], '2013': [97, 102, 107], 'Accepted': [98], '28,': [101], 'Published': [103], '30,': [106], 'Abstract': [108], 'C-X-C': [109], 'chemokine': [110], 'receptor': [111], 'type': [112], '4': [113], '(CXCR4)': [114], 'is': [115, 141], 'known': [116], 'to': [117, 134, 143, 213, 246, 266, 350], 'regulate': [118], 'lung,': [119], 'pancreatic': [120], 'prostate': [122], 'cancer': [123, 263, 292, 403], 'cells.': [125, 187, 199, 215, 234, 248, 268, 293, 328, 352], 'In': [126, 216], 'CXCR4': [129, 240, 250, 269, 294, 314, 338, 359, 363, 381, 398], 'signalling': [130, 382, 399], 'has': [131, 157, 383], 'been': [132, 159], 'reported': [133], 'be': [135, 410], 'a': [136, 321], 'mediator': [137], 'metastasis,': [139], 'linked': [142], 'poor': [144], 'prognosis.': [145], 'However': [146], 'its': [147, 272], 'role': [148], 'in': [149, 210, 254, 287, 332, 337, 347, 356, 361, 412], 'normal': [150, 202, 279, 387], 'malignant': [152, 172, 309, 389], 'cell': [155, 177, 183, 300, 311, 392, 405], 'function': [156], 'not': [158], 'investigated.': [160], 'Anoikis': [161], 'resistant': [162], '(AR)': [163], 'cells': [164, 189, 203, 222, 236, 264, 281, 319, 341, 365, 369], 'were': [165], 'collected': [166], 'from': [167], 'immortalised': [168], '(MCF10A,': [169], '226L)': [170], '(MCF7,': [173], 'T47D,': [174], 'SKBR3)': [175], 'lines': [178, 282], 'assessed': [180], 'for': [181, 228, 376], 'enrichment': [184], 'versus': [185], 'unsorted': [186, 198, 214, 233, 247], 'AR': [188, 201, 221, 235], 'had': [190, 223, 344], 'significantly': [191, 238, 322], 'higher': [192, 253], 'mammosphere': [193], 'forming': [194], 'efficiency': [195], '(MFE)': [196], 'than': [197], 'The': [200], 'demonstrated': [204, 320, 336], 'increased': [205, 284, 298, 323], 'formation': [206, 414], '3D': [208], 'structures': [209], 'Matrigel': [211], 'compared': [212, 231, 245, 265, 325, 349, 366], 'vivo,': [217], 'SKBR3': [218], 'T47D': [220, 288], '7-': [224], '130-fold': [226], 'enrichments': [227], 'tumour': [229, 413], 'formationrespectively,': [230], 'with': [232, 326, 367], 'contained': [237], 'elevated': [239], 'transcript': [241], 'protein': [243], 'levels': [244], 'Importantly,': [249], 'mRNA': [251], 'was': [252, 334, 370], 'cell-enriched': [256], 'CD44': [257], '+': [258, 315], '/CD24': [259], '-': [260], 'patient-derived': [261, 290], 'non-enriched': [267], 'stimulation': [270], 'by': [271, 296], 'ligand': [273], 'reduced': [275, 303], 'MFE': [276, 286, 324, 333], 'the': [278, 285, 304, 308, 362, 377, 416], 'but': [283, 302], 'inhibition': [295, 360], 'AMD3100': [297], 'activity': [301], 'self-renewal': [305, 348, 357], 'capacity': [306], 'line': [312], 'T47D.': [313], 'FACS': [316], 'sorted': [317], 'MCF7': [318, 340], 'CXCR4-': [327], 'This': [329], 'significant': [330], 'increase': [331, 346], 'further': [335], 'over-expressing': [339, 364], 'which': [342], 'also': [343, 371], 'an': [345], 'parental': [351, 368], 'A': [353], 'greater': [354], 'reduction': [355], 'following': [358], 'observed.': [372], 'Our': [373], 'data': [374], 'establish': [375], 'first': [378], 'time': [379], 'that': [380, 397], 'contrasting': [384], 'effects': [385], 'on': [386], 'activity.': [393], 'Here,': [394], 'we': [395], 'demonstrate': [396], 'specifically': [400], 'regulates': [401], 'activities': [406], 'may': [408], 'therefore': [409], 'important': [411], 'at': [415], 'sites': [417], 'metastases.': [419]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2117158095', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-16T18:54:49.338134', 'created_date': '2016-06-24'}