Publication Information

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2829, 2835, 2845, 2881, 2897, 2904, 2908, 2915, 2931, 3040, 3053, 3287, 3315, 3371, 3391, 3497, 3597, 3663, 3710, 3779, 3807, 3811, 3827, 3851, 3860, 3867, 3870, 3876, 3880, 3887, 3890, 3908, 3913, 3917, 3939, 3947, 3977, 3997, 4003, 4010, 4018, 4022, 4164, 4169, 4260, 4295, 4299, 4315, 4334, 4363, 4389, 4393, 4421, 4425, 4429, 4438, 4442, 4452, 4484, 4493, 4502, 4598, 4602, 4621, 4639, 4642, 4646, 4649], 'tumor': [6, 158, 307, 316, 467], 'necrosis': [7, 159, 308, 317], 'factor': [8, 160, 309], 'receptor': [9, 161, 335, 379, 994, 1224, 1480, 1665, 2112, 2437, 2465, 2885, 2943], 'superfamily': [10, 162, 381, 1330], 'and': [11, 26, 31, 44, 54, 91, 110, 121, 141, 163, 178, 183, 196, 206, 243, 262, 273, 293, 372, 384, 424, 453, 465, 556, 800, 812, 998, 1111, 1373, 1437, 1672, 1790, 1940, 2056, 2123, 2138, 2187, 2245, 2250, 2261, 2342, 2349, 2357, 2381, 2431, 2460, 2470, 2479, 2515, 2524, 2544, 2561, 2583, 2657, 2681, 2743, 2748, 2796, 3155, 3178, 3194, 3210, 3257, 3266, 3274, 3283, 3314, 3435, 3459, 3494, 3503, 3519, 3542, 3549, 3688, 3704, 3742, 3757, 3845, 3875, 3930, 3970, 4017, 4029, 4085, 4103, 4121, 4139, 4163, 4192, 4206, 4244, 4267, 4282, 4323, 4371, 4428, 4472, 4476, 4483, 4496, 4648], 'serves': [12, 164, 989], 'as': [13, 165, 419, 450, 551, 578, 804, 990, 1091, 1227, 1381, 2096, 2156, 2333, 2335, 2389, 2750, 2938, 2963, 3039, 3101, 3217, 3326, 3439, 3526, 3601, 4093, 4420, 4437], 'key': [15, 167, 2344], 'regulator': [16, 168, 1094], 'B': [18, 170, 324, 329, 544, 567, 1109], 'cell': [19, 89, 171, 241, 325, 330, 415, 468, 545], 'function.': [20, 172], 'binds': [22, 174, 1003, 1667], 'two': [23, 33, 175, 185, 1332, 1337, 1675, 1801, 2229, 2364, 3158, 3265, 3282], 'ligands,': [24, 176], 'APRIL': [25, 53, 177, 205, 447, 536, 799, 997, 1228, 1477, 1512, 1777, 2137, 2299, 2348, 2386, 2412, 2433, 2472, 2953, 3253, 3885, 4138, 4396, 4431, 4482], 'BAFF,': [27, 55, 179, 207, 323, 2740], 'with': [28, 116, 180, 268, 1674, 2063, 2227, 2577, 2685, 2867, 3383, 3477, 3778, 3810, 3850, 3992, 4158, 4263, 4302, 4309, 4337, 4357, 4388, 4451], 'high': [29, 49, 133, 181, 201, 285, 992, 2133, 2294, 2713, 2839], 'affinity': [30, 50, 100, 134, 182, 202, 252, 286, 993, 2134, 2295, 2356], 'contains': [32, 98, 184, 250, 1282, 3131, 4620], 'cysteine-rich': [34, 186, 341, 1288], 'domains': [35, 187, 1289, 1484], '(CRDs)': [36, 188], 'in': [37, 41, 189, 193, 511, 540, 797, 1089, 1105, 1113, 1293, 1353, 1375, 1658, 1668, 1799, 2106, 2366, 2518, 2633, 2643, 2726, 2813, 2880, 2957, 3446, 3461, 3523, 3675, 3686, 3697, 3916, 3936, 3976, 3999, 4025, 4089, 4100, 4149, 4272, 4305, 4314, 4327, 4353, 4362, 4375, 4487, 4601, 4630], 'its': [38, 190, 509, 2228], 'extracellular': [39, 191, 1276, 2368, 4603], 'region;': [40, 192], 'contrast,': [42, 194, 1376], 'BCMA': [43, 195, 813, 1002, 1172, 1235, 1372, 1941], 'BR3,': [45, 197, 333, 1374, 1650], 'other': [47, 199, 1346, 1393], 'known': [48, 200, 449, 550, 577, 1394], 'receptors': [51, 203, 386, 2248, 2351, 4526], 'for': [52, 101, 204, 253, 561, 995, 1182, 1508, 1931, 2119, 2160, 2280, 2293, 2378, 2468, 2494, 2646, 2663, 2717, 2737, 2889, 2949, 3199, 3279, 3296, 3323, 3803, 3923, 3928, 3934, 3986, 4002, 4255, 4424, 4441, 4492, 4501], 'respectively,': [56, 208], 'contain': [57, 209, 1383, 2052], 'only': [58, 210, 1005, 1384, 1392, 2115, 2125, 2286, 2372, 3398], 'single': [60, 139, 212, 291, 345, 1386, 1399, 2127, 2374, 4609], 'or': [61, 213, 1387, 1478, 1513, 1651, 2113, 2143, 2241, 2300, 2649, 2721, 2954, 3204, 3960, 3973], 'partial': [62, 214, 1388], 'CRD.': [63, 215], 'However,': [64, 216, 986], 'another': [65, 217], 'form': [66, 84, 218, 236, 2270], 'exists': [69, 221], 'wherein': [70, 222, 4593], 'N-terminal': [72, 224, 2275, 2617, 2794], 'CRD': [73, 95, 225, 247, 1400, 2276, 2289, 4600], 'removed': [75, 227, 2700, 4155], 'by': [76, 129, 228, 281, 462, 1946, 2499, 2621, 2701, 2793, 2834, 2865, 3457, 3595, 3736, 3842, 4156, 4270, 4385, 4607, 4614], 'alternative': [77, 229, 2268, 4616], 'splicing.': [78, 230], 'We': [79, 231, 2264], 'find': [80, 232, 4523], 'that': [81, 92, 124, 233, 244, 276, 404, 459, 1099, 1232, 1663, 1787, 1792, 2220, 2266, 2285, 2313, 2999, 4435, 4635], 'this': [82, 234, 1664, 1949, 4026, 4615], 'shorter': [83, 235], 'capable': [86, 238], 'ligand-induced': [88, 240], 'signaling': [90, 242, 570], 'second': [94, 246], 'alone': [96, 248, 988, 1778, 4397], '(TACI_d2)': [97, 249, 2290], 'full': [99, 251], 'both': [102, 254, 806, 996, 1483, 2047, 2148, 2379, 4447], 'ligands.': [103, 255], 'Furthermore,': [104, 256, 2282], 'we': [105, 142, 257, 294, 2252, 2283, 4585], 'report': [106, 258], 'solution': [108, 260, 2303, 2814, 3861, 4126, 4197], 'structure': [109, 261, 1775, 2304, 3740, 3862, 3878, 3919, 3991, 4394, 4495, 4504], 'alanine-scanning': [111, 263, 2318], 'mutagenesis': [112, 264, 2319], 'TACI_d2': [114, 266, 2306, 2705, 3047, 3514, 3874, 4086], 'along': [115, 267], 'co-crystal': [117, 269, 2329], 'structures': [118, 270, 1644, 2330, 3823, 3834, 3849, 3899, 4382, 4448], 'APRIL·TACI_d2': [120, 272, 2332, 4281, 4300, 4426, 4494], 'APRIL·BCMA': [122, 274, 2336, 4172, 4219, 4289, 4335, 4443, 4503], 'complexes': [123, 275, 2337], 'together': [125, 277, 2150], 'reveal': [126, 278], 'mechanism': [128, 280], 'which': [130, 282, 1291, 1496, 2352, 4596], 'engages': [132, 284], 'ligand': [135, 287, 458, 1300, 1935, 2104, 2121, 2154, 2322, 2354, 2855, 2872, 2937], 'binding': [136, 288, 1509, 1795, 1936, 2105, 2155, 2296, 2323, 2355, 2438, 2466, 2818, 2849, 2935, 2950, 3001, 3200, 3381], 'through': [137, 289, 571, 4527], 'CRD,': [140, 292, 340, 1389], 'highlight': [143, 295, 2343], 'sources': [144, 296], 'ligand-receptor': [146, 298, 1923, 2811], 'specificity': [147, 299, 1937], 'within': [148, 300], 'APRIL/BAFF': [150, 302], 'system.': [151, 303, 395], 'Members': [304], '(TNF)': [310], '1The': [311], 'abbreviations': [312], 'used': [313, 2414, 2808, 2912, 3092], 'are:': [314], 'TNF,': [315], 'factor;': [318, 327], 'APRIL,': [319, 3202], 'proliferation-inducing': [321], 'ligand;': [322], 'activation': [326, 546], 'BCMA,': [328, 1649, 2251], 'maturation': [331], 'antigen;': [332], 'BLyS/BAFF': [334], '3;': [336], 'CAPS,': [337, 2729, 4247], '3-(cyclohexylamino)propanesulfonic': [338], 'acid;': [339, 350], 'domain;': [342], 'HSQC,': [343], 'heteronuclear': [344], 'quantum': [346], 'coherence;': [347], 'MES,': [348, 4200, 4232], '4-morpholineethanesulfonic': [349], 'NFκB,': [351], 'nuclear': [352, 355], 'factor-κB;': [353], 'NOE,': [354], 'Overhauser': [356], 'effect;': [357], 'NOESY,': [358], 'NOE': [359, 3699, 3705, 3712, 3959, 4023], 'spectroscopy;': [360], 'PEG,': [361], 'polyethylene': [362], 'glycol;': [363], 'r.m.s.d.,': [364], 'root': [365], 'mean': [366, 3990], 'square': [367], 'deviation;': [368], 'TACI,': [369, 1486, 2371, 4626], 'transmembrane': [370, 401], 'activator': [371], 'CAML': [373], 'interactor;': [374], 'TNFR,': [375, 1440], 'TNF': [378, 457], 'superfamily.': [380], 'ligands': [383, 397, 1802], 'their': [385, 795], '(TNFR)': [387], 'are': [388, 398, 802, 1341, 1377, 1401, 2473, 3411], 'critical': [389], 'regulators': [390], 'adaptive': [393], 'immune': [394, 414], 'The': [396, 1169, 1275, 1391, 1774, 2302, 2328, 2785, 2857, 2920, 3299, 3821, 3847, 4135, 4218, 4381, 4611], 'type': [399], 'II': [400], 'protein': [402, 2613, 2661, 4120, 4191, 4643], 'cytokines': [403], 'have': [405, 2057, 2218, 2253], 'diverse': [406], 'and,': [407], 'at': [408, 1087, 2530, 2640, 2837, 3134, 3143, 3163, 3185, 3290, 3309, 3468, 4110, 4181, 4292, 4294], 'times,': [409], 'opposing': [410], 'effects': [411], 'on': [412, 1679, 2569, 2586, 2722, 2853, 3380, 3471, 3950, 4481], 'various': [413], 'types': [416], 'including': [417, 1482, 4644], 'acting': [418], 'costimulatory': [420], 'molecules,': [421], 'apoptotic': [422], 'agents,': [423], 'growth': [425, 469], 'factors': [426], '(1Locksley': [427], 'R.M.': [428, 819], 'Killeen': [429], 'N.': [430, 488, 591, 853, 1251, 1457, 1606, 1868], 'Lenardo': [431], 'M.J.': [432], 'Cell.': [433, 1875], '2001;': [434, 693, 734, 762, 828, 1135, 1424, 4550], '104:': [435], '487-501Abstract': [436], 'Full': [437, 439, 765, 767, 831, 833, 976, 978, 1043, 1045, 1075, 1077, 1159, 1161, 1313, 1315, 1427, 1429, 1537, 1539, 1633, 1635, 1879, 1881, 1974, 1976, 2175, 2177, 2775, 2777, 2988, 2990, 3080, 3082, 3242, 3244, 3353, 3355, 4056, 4058, 4553, 4555], 'Text': [438, 440, 766, 768, 832, 834, 977, 979, 1044, 1046, 1076, 1078, 1160, 1162, 1314, 1316, 1428, 1430, 1538, 1540, 1634, 1636, 1880, 1882, 1975, 1977, 2176, 2178, 2776, 2778, 2989, 2991, 3081, 3083, 3243, 3245, 3354, 3356, 4057, 4059, 4554, 4556], 'PDF': [441, 769, 835, 980, 1047, 1079, 1163, 1317, 1431, 1541, 1637, 1883, 1978, 2179, 2779, 2992, 3084, 3246, 3357, 4060, 4557], 'PubMed': [442, 503, 531, 618, 671, 696, 737, 770, 789, 872, 923, 981, 1048, 1080, 1138, 1164, 1216, 1270, 1318, 1367, 1432, 1470, 1542, 1571, 1600, 1638, 1707, 1736, 1769, 1812, 1831, 1858, 1884, 1913, 1979, 2008, 2041, 2089, 2180, 2213, 2406, 2455, 2780, 2993, 3034, 3085, 3124, 3247, 3358, 3586, 3628, 3730, 3794, 4061, 4080, 4415, 4467, 4558, 4580], 'Scopus': [443, 504, 532, 619, 672, 697, 738, 771, 790, 836, 873, 924, 982, 1049, 1081, 1139, 1165, 1217, 1271, 1319, 1368, 1433, 1471, 1543, 1572, 1601, 1639, 1708, 1737, 1770, 1813, 1832, 1859, 1885, 1914, 1980, 2009, 2042, 2090, 2181, 2214, 2407, 2456, 2781, 2994, 3035, 3086, 3125, 3248, 3359, 3587, 3629, 3652, 3731, 3795, 4062, 4081, 4348, 4416, 4468, 4559, 4581], '(3038)': [444], 'Google': [445, 506, 534, 621, 674, 699, 740, 773, 792, 838, 875, 926, 984, 1051, 1083, 1141, 1167, 1219, 1273, 1321, 1370, 1435, 1473, 1545, 1574, 1603, 1641, 1710, 1739, 1772, 1815, 1834, 1861, 1887, 1916, 1982, 2011, 2044, 2092, 2183, 2216, 2409, 2458, 2783, 2996, 3037, 3088, 3127, 3250, 3361, 3589, 3631, 3654, 3733, 3797, 4064, 4083, 4350, 4418, 4470, 4561, 4583], 'Scholar).': [446, 535, 793, 985, 1084, 1168, 1220, 1274, 1322, 1371, 1474, 1642, 1773, 1917, 2045, 2184, 2410, 2784, 3089, 3128, 3251, 3590, 3655, 3798], '(also': [448, 549, 576], 'TNSF13A,': [451], 'TALL-2,': [452], 'TRDL-1)': [454], 'overexpressed': [461], 'some': [463], 'tumors': [464], 'stimulates': [466], '(2Hahne': [470], 'M.': [471, 476, 480, 524, 638, 687, 724, 743, 755, 817, 894, 902, 1008, 1024, 1116, 1122, 1148, 1560, 1608, 1696, 1837, 1997, 3023, 3617, 3636, 3643, 4531, 4543, 4564], 'Kataoka': [472], 'T.': [473, 486, 935, 1018, 1126, 1408, 1410, 3574, 3717], 'Schro': [474], '̈ter': [475], 'Hofmann': [477, 586], 'K.': [478, 587, 630, 681, 708, 722, 859, 939, 1020, 1257, 1847, 1900, 3334, 3581, 3723], 'Irmler': [479], 'Bodmer': [481, 588], 'J.-L.': [482, 589, 1302, 2164], 'Schneider': [483, 715, 777, 842, 879, 1240, 1303, 2165], 'P.': [484, 581, 595, 603, 634, 716, 778, 780, 821, 841, 843, 880, 937, 957, 965, 1146, 1239, 1241, 1304, 1447, 2166, 3720], 'Bornand': [485], 'Holler': [487, 590, 852, 1250], 'French': [489, 1615], 'L.E.': [490], 'Sordat': [491], 'B.': [492, 652, 677, 747, 751, 955, 1120, 1550, 1686, 1987, 3013, 3607, 4535, 4539], 'Rimoldi': [493], 'D.': [494, 601, 636, 642, 931, 949, 951, 1016, 1128, 1144, 1152, 1610, 3572], 'Tschopp': [495, 610, 727, 864, 913, 1262, 1305, 2167], 'J.': [496, 497, 611, 612, 648, 654, 664, 728, 782, 847, 865, 866, 914, 917, 970, 1037, 1058, 1069, 1210, 1245, 1263, 1264, 1306, 1453, 1520, 1531, 1554, 1624, 1690, 1746, 1825, 1852, 1870, 1957, 1968, 1991, 2018, 2168, 2400, 2449, 2758, 2769, 2971, 2982, 3017, 3063, 3074, 3225, 3236, 3342, 3347, 3530, 3611, 3639, 3646, 3724, 3788, 4039, 4050, 4074, 4409], 'Exp.': [498, 613, 867, 918, 1211, 1265], 'Med.': [499, 614, 868, 919, 1212, 1266], '1998;': [500], '188:': [501], '1185-1190Crossref': [502], '(465)': [505], 'Scholar);': [507], 'however,': [508, 1335, 1934, 2316], 'function': [510, 1097, 2940], 'normal': [512, 563], 'biology': [513], 'less': [515, 1174], 'clear': [516], '(3Medema': [517], 'J.P.': [518], 'Planelles-Carazo': [519], 'L.': [520, 849, 884, 1028, 1247, 1406, 1748, 1752, 1866, 2020, 2024], 'Hardenbert': [521], 'G.': [522, 1764, 1804, 1874, 2036, 3576, 3783], 'Hahne': [523], 'Cell': [525], 'Death': [526], 'Differ.': [527], '2003;': [528, 786, 1040, 1156, 1467, 1568, 1597, 1704, 1733, 1766, 2005, 2038, 2086, 2210, 3031, 3350, 3625], '10:': [529, 829, 1598, 1734, 2087, 2211], '1121-1125Crossref': [530], '(42)': [533], 'most': [538], 'similar': [539, 1343, 1785, 1920, 2311, 2464], 'sequence': [541, 1348, 1490, 1502], 'to': [542, 1179, 1344, 1510, 1648, 1782, 1786, 1943, 2061, 2097, 2103, 2131, 2153, 2297, 2312, 2326, 2551, 2559, 2567, 2659, 2669, 2678, 2809, 2823, 2913, 2952, 2955, 3093, 3806, 3858, 3884, 3906, 3911, 3938, 3989, 4105, 4176, 4224, 4522], 'factor,': [547], 'BAFF': [548, 558, 801, 999, 1004, 1096, 1479, 1514, 1646, 1681, 1789, 2064, 2139, 2225, 2350, 2956, 3000, 3203, 3270, 4525], 'TNSF13B,': [552], 'BLyS,': [553], 'TALL-1,': [554], 'THANK,': [555], 'zTNF4).': [557], 'essential': [560], 'development': [564], 'mature': [566], 'cells': [568, 1110, 1189, 1231, 2528], 'via': [569, 1925], 'divergent': [573], 'TNFR': [574, 1281, 1329, 1355, 2240], 'BR3': [575, 1939, 2249], 'BAFF-R)': [579], '(4Schneider': [580], 'MacKay': [582, 889], 'F.': [583, 706, 776, 855, 890, 900, 1012, 1253, 1841, 3785], 'Steiner': [584], 'V.': [585, 650, 1414], 'Ambrose': [592, 731, 862, 915, 1033, 1260], 'C.': [593, 605, 714, 720, 732, 857, 863, 904, 916, 1026, 1034, 1201, 1255, 1261, 1845, 1898], 'Lawton': [594], 'Bixler': [596, 703, 891, 1013], 'S.': [597, 656, 685, 753, 851, 1124, 1249, 1443, 1455, 1459, 1762, 2034, 3119, 3338, 4541], 'Acha-Orbea': [598], 'H.': [599, 1118, 1416, 1591, 1612, 1727, 2080, 2204, 3578, 4570], 'Valmori': [600], 'Romero': [602], 'Werner-Favre': [604], 'Zubler': [606], 'R.H.': [607], 'Browning': [608, 729, 781, 860, 909, 1258], 'J.L.': [609, 679, 730, 861, 910, 1259], '1999;': [615, 668, 3791], '189:': [616], '1747-1756Crossref': [617], '(1151)': [620], 'Scholar,': [622, 675, 700, 741, 774, 839, 876, 927, 1052, 1142, 1546, 1575, 1604, 1711, 1740, 1816, 1835, 1862, 1888, 1983, 2012, 3632, 4065, 4562], '5Moore': [623], 'P.A.': [624, 967], 'Belvedere': [625], 'O.': [626, 646, 1902], 'Orr': [627], 'A.': [628, 825, 912, 1030, 1843, 3109, 3111, 3120, 3787, 4572], 'Pieri': [629], 'LaFleur': [631, 950], 'D.W.': [632], 'Feng': [633, 936], 'Soppet': [635], 'Charters': [637], 'Gentz': [639, 1903], 'R.': [640, 1750, 1904, 2022], 'Parmelee': [641], 'Li': [643, 1891], 'Y.': [644, 906, 929, 941, 1742, 1864, 1892, 1894, 2014], 'Galperina': [645, 1901], 'Giri': [647], 'Roschke': [649], 'Nardelli': [651, 954], 'Carrell': [653, 932], 'Sosnovtseva': [655], 'Greenfield': [657], 'W.': [658, 1614, 4342], 'Ruben': [659, 958], 'S.M.': [660, 959], 'Olsen': [661, 962], 'H.S.': [662, 963], 'Fikes': [663], 'Hilbert': [665], 'D.M.': [666, 1616, 1820, 2395, 2444, 4069, 4404], 'Science.': [667, 692, 733, 1363], '285:': [669], '260-263Crossref': [670], '(1022)': [673], '6Schiemann': [676], 'Gommerman': [678], 'Vora': [680, 707], 'Cachero': [682, 711, 844, 887, 1017, 1242, 1838], 'T.G.': [683, 712, 845, 888, 1243, 1839], 'Shulga-Morskaya': [684], 'Dobles': [686], 'Frew': [688], 'E.': [689, 947, 1022, 1906], 'Scott': [690, 709], 'M.L.': [691, 710], '293:': [694, 735], '2111-2114Crossref': [695], '(906)': [698], '7Thompson': [701], 'J.S.': [702, 878, 1010], 'S.A.': [704, 815, 892, 898, 1014, 1062, 1524, 1961, 2762, 2975, 3067, 3229, 4043, 4566], 'Qian': [705, 854, 899, 1011, 1252, 1840], 'Hession': [713], 'Sizing': [717], 'I.D.': [718], 'Mullen': [719, 856, 1254, 1844], 'Strauch': [721, 858, 1256, 1846], 'Zafari': [723, 893, 1023], 'Benjamin': [725, 907, 1025], 'C.D.': [726, 908], '2108-2111Crossref': [736], '(777)': [739], '8Yan': [742], 'Brady': [744, 4532], 'J.R.': [745, 4533], 'Chan': [746, 1119, 4534], 'Lee': [748, 1580, 1590, 1592, 1613, 1716, 1726, 1728, 2069, 2079, 2081, 2193, 2203, 2205, 4536], 'W.P.': [749, 4537], 'Hsu': [750, 1035, 1848, 4538], 'Harless': [752, 4540], 'Cancro': [754, 4542], 'Grewal': [756, 1129, 1153, 1617, 4544, 4567], 'I.S.': [757, 1130, 1154, 1618, 4545, 4568], 'Dixit': [758, 822, 1131, 1149, 1561, 1627, 1697, 1998, 3024, 3618, 4546, 4573], 'V.M.': [759, 823, 1132, 1150, 1562, 1628, 1698, 1999, 3025, 3619, 4547, 4574], 'Curr.': [760, 826, 1805, 4548], 'Biol.': [761, 827, 971, 1038, 1070, 1532, 1596, 1732, 1808, 1827, 1854, 1909, 1969, 2085, 2209, 2402, 2451, 2770, 2983, 3075, 3237, 3348, 3726, 4051, 4076, 4411, 4462, 4549], '11:': [763, 4551], '1547-1552Abstract': [764, 4552], '(348)': [772, 4560], '9Mackay': [775], 'Rennert': [779], 'Annu.': [783], 'Rev.': [784], 'Immunol.': [785, 1134, 4576], '21:': [787], '231-264Crossref': [788], '(791)': [791, 1218], 'Despite': [794], 'differences': [796, 2345, 3868], 'function,': [798], 'linked': [803], 'they': [805, 1382], 'can': [807, 1229], 'bind': [808, 1292], 'TNFRs': [810, 1380, 1395, 2162], '(10Marsters': [814], 'Yan': [816, 1147, 1559, 1607, 1695, 1996, 3022, 3616], 'Pitti': [818], 'Haas': [820], 'Ashkenazi': [824, 4571], '785-788Abstract': [830], '(315)': [837], '11Rennert': [840], 'Thompson': [846, 1009, 1244], 'Trabach': [848, 1246], 'Hertig': [850, 1248], '2000;': [869, 920, 973, 1267, 3121, 4577], '192:': [870, 921, 1268], '1677-1684Crossref': [871, 1269], '(221)': [874, 1272], '12Thompson': [877], 'Kalled': [881, 1031, 1850], 'S.L.': [882, 1032, 1851], 'Wang': [883, 1117, 1611, 4569], 'Lefevre': [885], 'E.A.': [886], 'Liu': [895, 1415], 'Z.-Y.': [896], 'Woodcock': [897], 'Batten': [901], 'Madry': [903], 'Richard': [905], 'Tsapis': [911], '129-135Crossref': [922], '(336)': [925], '13Wu': [928], 'Bressette': [930], 'J.A.': [933, 1412], 'Kaufman': [934], 'Taylor': [938], 'Gan': [940], 'Cho': [942], 'Y.H.': [943], 'Garcia': [944], 'A.D.': [945], 'Gollatz': [946], 'Dimke': [948], 'Migone': [952], 'T.S.': [953, 1896], 'Wei': [956], 'Ullrich': [960], 'S.J.': [961], 'Kanakaraj': [964], 'Moore': [966], 'Baker': [968, 1125], 'K.P.': [969], 'Chem.': [972, 1039, 1071, 1533, 1970, 2771, 2984, 3076, 3238, 3349, 4052], '275:': [974], '35478-35485Abstract': [975], '(216)': [983], 'because': [1000, 2418], 'monovalent': [1001], 'weakly': [1006], '(14Pelletier': [1007], 'Gong': [1015], 'Gilbride': [1019], 'Day': [1021], 'Gorelik': [1027], 'Whitty': [1029], 'Y.-M.': [1036, 1849], '278:': [1041, 1365, 3351], '33127-33133Abstract': [1042], '(77)': [1050, 1915], '15Patel': [1053], 'D.R.': [1054, 1516, 1583, 1719, 1953, 2072, 2196, 2754, 2967, 3059, 3221, 4035], 'Wallweber': [1055, 1517, 1954, 2755, 2968, 3060, 3222, 4036], 'H.J.A.': [1056, 1518, 1818, 1955, 2393, 2442, 2756, 2969, 3061, 3223, 4037, 4067, 4402], 'Yin': [1057, 1519, 1553, 1623, 1689, 1956, 1990, 2757, 2970, 3016, 3062, 3224, 3341, 3610, 4038], 'Shriver': [1059, 1521, 1958, 2759, 2972, 3064, 3226, 4040], 'S.K.': [1060, 1461, 1522, 1959, 2760, 2973, 3065, 3227, 4041], 'Marsters': [1061, 1523, 1960, 2761, 2974, 3066, 3228, 4042, 4565], 'Gordon': [1063, 1525, 1621, 1962, 2763, 2976, 3068, 3230, 4044], 'N.C.': [1064, 1526, 1548, 1622, 1684, 1963, 1985, 2764, 2977, 3011, 3069, 3231, 3605, 4045], 'Starovasnik': [1065, 1527, 1565, 1625, 1701, 1821, 1964, 2002, 2396, 2445, 2765, 2978, 3028, 3070, 3232, 3622, 4046, 4070, 4405], 'M.A.': [1066, 1528, 1566, 1626, 1702, 1822, 1965, 2003, 2397, 2446, 2766, 2979, 3029, 3071, 3233, 3623, 4047, 4071, 4406], 'Kelley': [1067, 1529, 1555, 1691, 1966, 1992, 2767, 2980, 3018, 3072, 3234, 3612, 4048], 'R.F.': [1068, 1530, 1556, 1692, 1967, 1993, 2768, 2981, 3019, 3073, 3235, 3613, 4049], '2004;': [1072, 1213, 1534, 1809, 1828, 1971, 2403, 2452, 2772, 2985, 3077, 3239, 4053, 4077, 4412], '279:': [1073, 1535, 1972, 2773, 2986, 3078, 3240, 4054], '16727-16735Abstract': [1074, 1536, 1973, 2774, 2987, 3079, 3241, 4055], '(51)': [1082, 1544, 1981, 2782, 2995, 3087, 3249, 4063], 'functions,': [1086], 'least': [1088, 3291], 'part,': [1090], 'negative': [1093], 'given': [1098, 3378], 'loss': [1100], 'expression': [1103, 2607, 2682, 4528], 'results': [1104], 'overproduction': [1107], 'autoimmunity': [1112], 'mice': [1114], '(16Yan': [1115], 'Roose-Girma': [1121], 'Erickson': [1123, 1194], 'Tumas': [1127, 1151], 'Nat.': [1133, 1594, 1730, 1907, 2083, 2207, 4575], '2:': [1136], '638-643Crossref': [1137], '(341)': [1140], '17Seshasayee': [1143], 'Valdez': [1145], 'Immunity.': [1155, 1423, 1629], '18:': [1157], '279-288Abstract': [1158], '(342)': [1166], 'role': [1170], 'clear,': [1175], 'although': [1176], 'it': [1177, 2419], 'appears': [1178, 1942], 'be': [1180, 1783, 1944], 'important': [1181], 'survival': [1184], 'long': [1186], 'lived': [1187], 'plasma': [1188], "(18O'Connor": [1190], 'B.P.': [1191], 'Raman': [1192], 'V.S.': [1193], 'L.D.': [1195], 'Cook': [1196], 'W.J.': [1197, 1564, 1700, 2001, 3027, 3532, 3621, 3645], 'Weaver': [1198], 'L.K.': [1199], 'Ahonen': [1200], 'Lin': [1202], 'L.-L.': [1203], 'Mantchev': [1204], 'G.T.': [1205], 'Bram': [1206, 1361], 'R.J.': [1207, 1209, 1362], 'Noelle': [1208], '199:': [1214], '91-97Crossref': [1215], 'A': [1221, 2900, 3451, 4275], 'third': [1222], 'APRIL-specific': [1223], 'may': [1225, 4007], 'exist': [1226], 'stimulate': [1230], 'express': [1233], 'neither': [1234], 'nor': [1236], '(11Rennert': [1238], 'domain': [1277, 2100, 2128, 2310, 2369, 2375, 2619, 3882], 'typical': [1280, 1352], 'multiple': [1283], 'copies': [1284], 'so-called': [1286, 1493], '∼40-residue': [1287], '(CRDs),': [1290], 'monomer-monomer': [1295], 'interfaces': [1296, 2341], 'trimeric': [1299], '(19Bodmer': [1301, 2163], 'Trends': [1307, 2169], 'Biochem.': [1308, 2170], 'Sci.': [1309, 2171, 3117], '2002;': [1310, 1630, 1855, 1876, 1910, 2172, 3727, 3831], '27:': [1311, 2173], '19-26Abstract': [1312, 2174], '(724)': [1320, 2182], 'possessing': [1331, 1396], 'CRDs;': [1333], 'interestingly': [1334], 'CRDs': [1338, 2048, 2149, 2365], 'more': [1342, 2236, 2246], 'each': [1345, 2099, 3297, 3310, 3324], '(∼50%': [1347], 'identity)': [1349], 'than': [1350, 2424, 3007, 3404], 'family': [1356], '(20von': [1357], 'Bu': [1358], '̈low': [1359], 'G.-U.': [1360], '1997;': [1364, 4345], '138-141Crossref': [1366], '(313)': [1369], 'unusually': [1378], 'small': [1379, 2244, 3393], 'respectively.': [1390, 3268, 3285], 'just': [1397], 'FN14': [1402], '(21Wiley': [1403], 'S.R.': [1404], 'Cassiano': [1405], 'Lofton': [1407], 'Davis-Smith': [1409], 'Winkles': [1411], 'Lindner': [1413], 'Daniel': [1417], 'T.O.': [1418], 'Smith': [1419], 'C.A.': [1420], 'Fanslow': [1421], 'W.C.': [1422], '15:': [1425], '837-846Abstract': [1426], '(319)': [1434], 'Scholar)': [1436, 2217, 3038, 3362, 3734, 4084, 4351, 4471, 4584], 'Drosophila': [1439], 'Wengen': [1441], '(22Kauppila': [1442], 'Maaty': [1444], 'W.S.': [1445], 'Chen': [1446], 'Tomar': [1448], 'R.S.': [1449], 'Eby': [1450], 'M.T.': [1451, 3340], 'Chapo': [1452], 'Chew': [1454], 'Rathore': [1456], 'Zachariah': [1458], 'Sinha': [1460], 'Abrams': [1462], 'J.M.': [1463], 'Chaudhary': [1464], 'P.M.': [1465], 'Oncogene.': [1466], '22:': [1468], '4860-4867Crossref': [1469], '(132)': [1472], 'All': [1475, 3482], 'human': [1476, 2050, 2426, 2432, 2471, 2595, 2741, 2744, 4591], 'CRDs,': [1481], 'share': [1487], 'common': [1489, 1950], 'feature,': [1491], 'DXL': [1494, 1656, 1794, 1927, 2054], 'motif,': [1495], 'consists': [1497], 'conserved': [1500, 1676, 1798], '6-residue': [1501], '(Phe/Tyr/Trp)-Asp-Xaa-Leu-(Val/Thr)-(Arg/Gly).': [1503], 'This': [1504], 'motif': [1505, 1657, 1666, 1951, 2055], 'required': [1507, 2292], 'either': [1511, 2298, 2709, 2951], '(15Patel': [1515, 1952, 2753, 2966, 3058, 3220, 4034], '23Gordon': [1547, 1984], 'Pan': [1549, 1685, 1753, 1986, 2025, 3012, 3606], 'Hymowitz': [1551, 1687, 1823, 1988, 2398, 2447, 3014, 3608, 4072, 4407], 'S.G.': [1552, 1688, 1824, 1989, 2399, 2448, 3015, 3609, 4073, 4408], 'Cochran': [1557, 1619, 1693, 1994, 3020, 3614], 'A.G.': [1558, 1620, 1694, 1995, 3021, 3535, 3615], 'Fairbrother': [1563, 1699, 2000, 3026, 3531, 3620], 'Biochemistry.': [1567, 1703, 2004, 3030, 3582, 3624], '42:': [1569, 1705, 2006, 3032, 3626], '5977-5983Crossref': [1570, 1706, 2007, 3033, 3627], '(52)': [1573, 1709, 1833, 2010, 2408, 2457, 3036, 3630, 4082, 4417], '24Kim': [1576, 1712], 'H.M.': [1577, 1713, 2066, 2190], 'Yu': [1578, 1714, 2067, 2191], 'K.S.': [1579, 1715, 2068, 2192], 'M.E.': [1581, 1717, 2070, 2194], 'Shin': [1582, 1718, 2071, 2195], 'Kim': [1584, 1720, 2073, 2186, 2197], 'Y.S.': [1585, 1721, 2074, 2198], 'Paik': [1586, 1722, 2075, 2199], 'S.-G.': [1587, 1723, 2076, 2200], 'Yoo': [1588, 1724, 2077, 2201], 'O.J.': [1589, 1725, 2078, 2202], 'J.-O.': [1593, 1729, 2082, 2206], 'Struct.': [1595, 1731, 1807, 1908, 2084, 2208], '342-348Crossref': [1599, 1735, 2088, 2212], '(80)': [1602, 1738, 2091, 2215], '25Kayagaki': [1605], 'Seshasayee': [1609], '17:': [1631], '515-524Abstract': [1632], '(411)': [1640], 'Crystal': [1643], 'bound': [1647, 3883], 'peptide': [1653], 'presenting': [1654], 'β-hairpin': [1660], 'scaffold': [1661], 'show': [1662, 2265, 2338], 'hydrophobic': [1670], 'pocket': [1671], 'interacts': [1673], 'arginine': [1677], 'residues': [1678, 2600, 3987, 4624, 4634], 'surface': [1682, 2859], '(23Gordon': [1683, 3010, 3604], '26Liu': [1741, 2013], 'Hong': [1743, 2015], 'X.': [1744, 2016], 'Kappler': [1745, 1869, 2017], 'Jiang': [1747, 2019], 'Zhang': [1749, 1763, 1873, 2021, 2035], 'Xu': [1751, 1865, 2023], 'C.-H.': [1754, 2026], 'Martin': [1755, 2027], 'W.E.': [1756, 2028], 'Murphy': [1757, 2029], 'R.C.': [1758, 2030], 'Shu': [1759, 1871, 2031], 'H.-B.': [1760, 1872, 2032], 'Dai': [1761, 2033], 'Nature.': [1765, 2037], '423:': [1767, 2039], '49-56Crossref': [1768, 2040], '(116)': [1771, 2043], 'was': [1779, 2387, 2413, 2557, 2564, 2602, 2631, 2676, 2691, 2699, 2706, 2807, 2821, 2850, 2860, 2911, 3050, 3091, 3307, 3312, 3321, 3455, 3900, 4141, 4154, 4166, 4252, 4449, 4605], 'recently': [1780], 'shown': [1781, 2059], 'very': [1784], 'indicates': [1791], 'site': [1796, 1928, 2439], '(27Zhang': [1803], 'Opin.': [1806], '14:': [1810], '154-160Crossref': [1811], '(61)': [1814], '28Wallweber': [1817, 2441, 4066], 'Compaan': [1819, 2394, 2443, 4068, 4403], 'Mol.': [1826, 1853, 2401, 2450, 3725, 4075, 4410], '343:': [1829, 2404, 2453, 4078, 4413], '283-290Crossref': [1830, 2405, 2454, 4079, 4414], '29Karpusas': [1836], 'Boriack-Sjodin': [1842], '315:': [1856], '1145-1154Crossref': [1857], '(122)': [1860], '30Liu': [1863], 'Opalka': [1867], '108:': [1877], '383-394Abstract': [1878], '(178)': [1886], '31Oren': [1889], 'D.A.': [1890], 'Volovik': [1893], 'Morris': [1895], 'Dharia': [1897], 'Das': [1899], 'Arnold': [1905], '9:': [1911], '288-292Crossref': [1912], 'Thus,': [1918, 2359, 3894], 'mode': [1921], 'interaction': [1924, 2257], 'expected': [1930], 'APRIL-receptor': [1932], 'complexes;': [1933], 'determined': [1945], 'interactions': [1947, 2812], 'outside': [1948, 2435], 'Since': [2046], 'been': [2058], 'qualitatively': [2060], 'interact': [2062], '(24Kim': [2065, 2189], 'Scholar),': [2093, 2997], 'questions': [2094], 'remain': [2095], 'whether': [2098, 2114, 2136, 2233], 'actively': [2101], 'contributes': [2102], 'context': [2108], 'full-length': [2111], 'one': [2116, 3138], 'exploited': [2118], 'optimal': [2120], 'binding;': [2122], 'if': [2124], 'sufficient': [2130], 'achieve': [2132], 'binding,': [2135, 3254, 3271], 'favor': [2140], 'same': [2142, 2490, 3881], 'different': [2144], 'domains.': [2146], 'Alternatively,': [2147], 'could': [2151], 'contribute': [2152], 'typically': [2158, 3417], 'observed': [2159, 2909, 3915], 'multidomain': [2161, 2239], 'Additionally,': [2185], 'co-workers': [2188], 'postulated': [2219], 'might': [2222], 'span': [2223], 'adjacent': [2224], 'trimers': [2226], 'CRDs.': [2230], 'To': [2231], 'understand': [2232], 'functions': [2235], 'like': [2237, 2242], 'specific': [2247], 'characterized': [2254], 'APRIL-TACI': [2256], 'using': [2258, 2487, 2710, 2815, 2828, 2925, 3487, 3496, 3709, 3826, 3837, 3902, 4392], 'cell-based,': [2259], 'biochemical': [2260], 'structural': [2262], 'studies.': [2263], 'an': [2267, 2616, 2670, 2723, 3440, 4097, 4145, 4225, 4488, 4497, 4520], 'splice': [2269, 4588], 'lacking': [2273], 'still': [2278], 'functional': [2279, 3318], 'signaling.': [2281, 2383], 'found': [2284, 3308], 'membrane-proximal': [2288], 'BAFF.': [2301], 'reveals': [2307], 'compact': [2309], 'BCMA;': [2315], 'combinatorial': [2317], 'identified': [2320], 'additional': [2321, 3944, 4216, 4524], 'determinants': [2324], 'unique': [2325, 3135], 'TACI_d2.': [2327, 2629], 'well': [2334], 'remarkably': [2339], 'large': [2340], 'among': [2346], 'influence': [2353], 'specificity.': [2358], 'despite': [2360], 'presence': [2362, 2882], 'employed': [2377], 'APRIL-': [2380], 'BAFF-dependent': [2382], 'Protein': [2384, 2630, 3538], 'Production—Murine': [2385], 'produced': [2388, 2484], 'described': [2390, 2751, 2964, 3056, 3102, 3218, 3327, 3527, 3602], 'previously': [2391, 2752, 2965, 3057, 3103, 3219, 3328, 3528, 3603], '(28Wallweber': [2392, 4401], 'Murine': [2411], 'throughout': [2415], 'study': [2417], 'better': [2421], 'behaved': [2422], 'biochemically': [2423], 'recombinant': [2425], 'APRIL.': [2427], 'Differences': [2428], 'between': [2429, 2862, 3869], 'murine': [2430, 2469], 'lie': [2434], '(Ref.': [2440], 'Scholar': [2459, 3548], 'see': [2461, 3550], 'below),': [2462], 'thus,': [2463], 'affinities': [2467], 'expected.': [2474], 'Human': [2475, 2739], 'TACI_d1d2': [2476], '(residues': [2477, 2481, 3048], '21–116)': [2478], 'TACI_d1': [2480], '32–67)': [2482], 'were': [2483, 2504, 2522, 2549, 2581, 2746, 2791, 2887, 2893, 2923, 2946, 3197, 3215, 3260, 3277, 3294, 3466, 3485, 3515, 3559, 3593, 3658, 3701, 3707, 3749, 3770, 3801, 3824, 3835, 3856, 4087, 4174, 4212, 4221, 4290, 4383], 'from': [2485, 2526, 3262, 3517, 3561, 3660, 3751, 3772, 4009, 4113, 4184, 4434], 'baculovirus': [2486, 2508], 'essentially': [2488, 3100], 'procedure.': [2491], 'DNA': [2492, 2597], 'coding': [2493], 'fragments': [2497], 'followed': [2498, 2620, 3735, 3841], 'C-terminal': [2501, 3891], 'His': [2502, 2623], 'tag': [2503], 'subcloned': [2505, 2603, 3051], 'into': [2506, 2604, 3052], 'transfer': [2509], 'vector': [2510, 2608], 'pAcGP67B': [2511], '(Pharmingen).': [2512], 'After': [2513, 2575, 2666], 'transfection': [2514], 'viral': [2516], 'amplification': [2517], 'Sf9': [2519], 'cells,': [2520], 'proteins': [2521, 2790], 'expressed': [2523, 2632, 2747], 'secreted': [2525], 'Hi5': [2527], 'grown': [2529, 2639], '27': [2531], '°C.': [2532], '50': [2533, 2877, 3422, 3428, 3436], 'mm': [2534, 2539, 2542, 2687, 2728, 2733, 2869, 3420, 3423, 3429, 3432, 4242, 4246], 'Tris,': [2535], 'pH': [2536, 2556, 2730, 3426, 4133, 4201, 4233, 4248], '8.0,': [2537], '1': [2538, 2545, 2686, 4106, 4117, 4122, 4188, 4193], 'NiCl2,': [2540], '5': [2541], 'CaCl2,': [2543], 'μm': [2546, 3437], 'phenylmethylsulfonyl': [2547], 'fluoride': [2548], 'added': [2550], 'culture': [2553], 'medium,': [2554], 'adjusted': [2558], '7.6,': [2560], 'medium': [2563, 2645, 2652], 'filtered': [2565], 'prior': [2566], 'loading': [2568], 'nickel-nitrilotriacetic': [2571, 2695], 'acid': [2572, 2696, 3306], '(Qiagen)': [2573], 'column.': [2574, 2591, 2697, 4171], 'elution': [2576], 'imidazole,': [2578], 'relevant': [2579], 'fractions': [2580, 4173], 'pooled': [2582], 'purified': [2584, 2692, 2707, 2749, 2789, 4092, 4143], 'further': [2585, 2708], 'Superdex-75': [2588], '(S-75)': [2589], 'sizing': [2590, 4147], 'For': [2592, 3252, 3269, 3286], 'production': [2593], 'TACI_d2,': [2596], 'encoding': [2598, 3046], '68–109': [2601], 'pET32a': [2606], '(Novagen),': [2609], 'creating': [2610], 'fusion': [2612], 'consisting': [2614, 4258], 'thioredoxin': [2618], 'tag,': [2624], 'thrombin': [2625, 2702], 'cleavage': [2626, 4157], 'site,': [2627], 'then': [2628, 2704, 2894, 4152, 4268, 4638], 'Escherichia': [2634], 'coli': [2635], 'Origami': [2636], '(DE3)': [2637], 'cultures': [2638, 2667], '37': [2641], '°C': [2642, 2680, 3470, 4112, 4183], 'LB': [2644], 'unlabeled': [2647], 'protein,': [2648, 3421], 'M9': [2650], 'minimal': [2651], 'containing': [2653, 4116, 4187, 4229], 'uniformly': [2654], '13C-labeled': [2655, 3569], 'glucose': [2656], '[15N]NH4Cl': [2658], 'generate': [2660], 'samples': [2662, 2720, 3416], 'NMR': [2664, 2719, 3414, 3464, 3483, 3539, 3871], 'spectroscopy.': [2665], 'grew': [2668, 4109, 4180], 'A600': [2671], '0.7,': [2673], 'temperature': [2675], 'lowered': [2677], '16': [2679], 'induced': [2683], 'overnight': [2684], 'isopropyl': [2688], '1-thio-β-d-galactopyranoside.': [2689], 'Thioredoxin-TACI_d2': [2690], 'over': [2693, 2896, 4096, 4144, 4168], 'Thioredoxin': [2698], 'cleavage,': [2703], 'reverse': [2711], 'phase': [2712], 'performance': [2714], 'liquid': [2715, 4273], 'chromatography': [2716], 'S-75': [2724, 4098, 4146, 4170], 'column': [2725, 4099, 4148], '20': [2727, 3848, 4623], '9.7,': [2731], '400': [2732, 4241], 'NaCl': [2734], '(buffer': [2735], 'A)': [2736], 'crystallography.': [2738], 'BCMA-Fc,': [2742], 'BCMA-Z': [2745, 4140], 'identities': [2786], 'all': [2788], 'verified': [2792], 'sequencing': [2795], 'mass': [2797], 'spectrometry.': [2798], 'Competitive': [2799], 'Binding': [2800], 'Assays—A': [2801], 'BIAcore': [2802], '3000': [2803], 'instrument': [2804], '(BIAcore,': [2805], 'Inc.)': [2806], 'measure': [2810, 3369], 'competitive': [2817], 'format.': [2819], 'BCMA-Fc': [2820], 'coupled': [2822], 'CM4': [2825], 'sensor': [2826], 'chip,': [2827], 'amine': [2830], 'coupling': [2831], 'protocol': [2832], 'supplied': [2833], 'manufacturer,': [2836], 'density': [2840], '(4,500': [2841], 'resonance': [2842, 3480, 3511, 3521], 'units)': [2843], 'so': [2844], 'initial': [2846, 2905], 'rate': [2847, 2933], 'linearly': [2851], 'dependent': [2852], 'free': [2854, 2918, 2936], 'concentration.': [2856, 2944], 'chip': [2858], 'regenerated': [2861], 'sample': [2863, 3454, 3570], 'injections': [2864], 'washing': [2866], '10': [2868, 4245], 'HCl.': [2870], 'Fixed': [2871], 'concentrations': [2873, 2886], '(12.5': [2874], 'nm': [2875, 2878], 'BAFF;': [2876], 'thioredoxin-APRIL)': [2879], 'varying': [2884], 'incubated': [2888], '2': [2890], 'h.': [2891], 'Samples': [2892], 'passed': [2895], 'BCMA-Fc-coupled': [2898], 'surface.': [2899], 'linear': [2901], 'fit': [2902, 2929], 'on-rate': [2906], 'sensorgrams': [2910], 'calculate': [2914], 'concentration': [2916], 'ligand.': [2919], 'IC50': [2921], 'values': [2922, 3384, 3966], 'calculated': [2924, 3322, 3825, 3836, 3901], 'four-parameter': [2927], 'curve': [2928], 'fractional': [2932], 'competing': [2942], 'Receptors': [2945], 'also': [2947], 'tested': [2948], 'competition': [2959], 'enzyme-linked': [2960], 'immunosorbent': [2961], 'assay': [2962], 'except': [2998], 'assays': [3002], 'utilized': [3003], 'biotinylated': [3004, 3008], 'BR3·ECD': [3005], 'rather': [3006], '"mini-BR3"': [3009], 'probe.': [3041], 'Phage': [3042], 'Display': [3043], 'TACI_d2—DNA': [3045], '68–109)': [3049], 'phagemid': [3054], 'BCMA2-g3': [3055], 'TACI_d2-g3': [3090], 'prepare': [3094], 'three': [3095, 3180], '"shotgun': [3096], 'alanine"': [3097], 'scanning': [3098], 'libraries': [3099, 3263, 3280], '(32Weiss': [3104], 'G.A.': [3105], 'Watanabe': [3106], 'C.K.': [3107], 'Zhong': [3108], 'Goddard': [3110, 3502], 'Sidhu': [3112, 3345], 'S.S.': [3113, 3346], 'Proc.': [3114], 'Natl.': [3115], 'Acad.': [3116], 'U.': [3118], '97:': [3122], '8950-8954Crossref': [3123], '(265)': [3126], 'Each': [3129], 'library': [3130, 3137, 3157, 3179], 'shotgun': [3132, 3141, 3161, 3183], 'codons': [3133, 3142, 3162, 3184], 'positions:': [3136], 'has': [3139, 3159, 3181], '11': [3140], 'positions': [3144, 3164, 3186], '72,': [3145], '73,': [3146], '74,': [3147], '75,': [3148], '76,': [3149], '77,': [3150], '78,': [3151], '80,': [3152], '81,': [3153, 3166], '83,': [3154], '85;': [3156], '13': [3160], '79,': [3165], '82,': [3167], '84,': [3168], '87,': [3169], '88,': [3170], '91,': [3171], '92,': [3172], '94,': [3173], '95,': [3174], '96,': [3175], '97,': [3176], '98;': [3177], '8': [3182], '99,': [3187], '102,': [3188], '103,': [3189], '105,': [3190], '106,': [3191], '107,': [3192], '108,': [3193], '109.': [3195], 'Libraries': [3196], 'sorted': [3198], 'against': [3201], 'anti-tag': [3205], 'antibody': [3206], '(3C8:2F4': [3207], 'Genentech,': [3208], 'Inc.),': [3209], 'sequences': [3211, 3259, 3276, 3293, 3396], 'phage': [3213], 'clones': [3214], 'analyzed': [3216, 3261, 3278, 3295, 3495], '71,': [3255], '40,': [3256], '54': [3258], 'one,': [3264, 3281], 'three,': [3267, 3284], '70,': [3272], '50,': [3273], '53': [3275], 'display': [3288], 'selection,': [3289], '47': [3292, 4633], 'library.': [3298], 'number': [3300, 3394], 'times': [3302], 'particular': [3304], 'amino': [3305], 'position': [3311, 3325], 'tabulated,': [3313], 'normalized': [3316], 'wild-type/mutant': [3317], 'ratio,': [3319], 'F,': [3320], '(33Skelton': [3329], 'N.J.': [3330, 3537, 3634], 'Koehler': [3331], 'M.F.T.': [3332], 'Zobel': [3333], 'Wong': [3335], 'W.L.': [3336], 'Yeh': [3337], 'Pisabarro': [3339], 'Lasky': [3343], 'L.A.': [3344], '7645-7654Abstract': [3352], '(126)': [3360], '(see': [3363], 'Table': [3364, 3551], 'S3).': [3365], 'F': [3366, 3408], 'represents': [3367], 'apparent': [3372], 'effect': [3373, 3406, 3949], 'mutation': [3375], 'residue': [3379, 4629], 'affinity,': [3382], '>1': [3385], 'representing': [3386], 'deleterious': [3387], 'mutations.': [3388], 'Because': [3389], 'relatively': [3392], 'analyzed,': [3397], 'those': [3399], 'mutations': [3400], 'showing': [3401], 'greater': [3403], '10-fold': [3405], '(i.e.': [3407], '>': [3409], '10)': [3410], 'considered': [3412], 'significant.': [3413], 'Spectroscopy—NMR': [3415], 'contained': [3418], '∼1': [3419], 'sodium': [3424, 3433], 'phosphate,': [3425], '7.2,': [3427], 'NaCl,': [3430, 4243], '0.1': [3431, 4130, 4230], 'azide,': [3434], '1,4-dioxane': [3438], 'internal': [3441], 'chemical': [3442, 3776, 3808], 'shift': [3443], 'reference': [3444], 'standard': [3445], '90%': [3447], 'H2O,': [3448], '10%': [3449, 4207, 4238], 'D2O.': [3450, 3463, 3698], '"100%': [3452], 'D2O"': [3453], 'prepared': [3456], 'lyophilization': [3458], 'resuspension': [3460], '99.995%': [3462], 'spectra': [3465], 'acquired': [3467], '17': [3469], 'Bruker': [3473], 'DRX600': [3474], 'spectrometer': [3475], 'equipped': [3476], 'triple': [3479, 3520], 'cryoprobe.': [3481], 'data': [3484, 4278, 4286, 4301, 4307, 4336, 4355], 'processed': [3486], 'FELIX': [3488], '(version': [3489, 3500, 3830], '2000.1;': [3490], 'Accelrys,': [3491], 'San': [3492, 3508, 3546], 'Diego)': [3493], 'program': [3498, 3714, 3780, 3828, 4390, 4453], 'Sparky': [3499], '3.11,': [3501], 'Kneller,': [3504], 'University': [3505], 'California,': [3507], 'Francisco).': [3509], 'Backbone': [3510, 3591, 3766], 'assignments': [3512, 3554, 3706], 'obtained': [3516, 3560, 3659, 3708, 3750, 3771], 'double': [3518], 'experiments': [3522], 'H2O': [3524], 'solution,': [3525], '(34Cavanagh': [3529], 'Palmer': [3533, 3640], 'III,': [3534], 'Skelton': [3536], 'Spectroscopy:': [3540], 'Principles': [3541], 'Practice.': [3543], 'Academic': [3544], 'Press,': [3545], 'Diego1995Google': [3547], 'S1).': [3552], 'Stereospecific': [3553], 'leucine': [3556], 'methyl': [3557], 'groups': [3558], '1H-13C': [3563], 'HSQC': [3564], 'spectrum': [3565], '15%': [3568], '(35Neri': [3571], 'Szyperski': [3573], 'Otting': [3575], 'Senn': [3577], 'Wu': [3579, 3721], '̈thrich': [3580, 3722], '1989;': [3583], '28:': [3584], '7510-7516Crossref': [3585], '(568)': [3588], 'dynamics': [3592, 3840, 3844], 'investigated': [3594], 'analyzing': [3596], 'steady': [3598], 'state': [3599], '{1H}-15N-NOE': [3600], '36Skelton': [3633], 'Akke': [3635], 'Ko': [3637], '̈rdel': [3638], 'A.G.P.': [3641], 'Rance': [3642], 'Chazin': [3644], 'Magn.': [3647], 'Reson.': [3648], '1993;': [3649], '102:': [3650], '253-264Crossref': [3651], '(174)': [3653], 'Distance': [3656], 'restraints': [3657, 3748, 3769, 3800, 3905, 3945, 3994, 4016, 4024, 4478], 'analysis': [3661, 3752, 3773], 'following': [3664], 'NOESY': [3665, 3669, 3680, 3691], 'spectra:': [3666], 'three-dimensional': [3667, 3678, 3754, 3758], '1H-15N-edited': [3668], '(200': [3670], 'ms': [3671, 3682, 3693, 3762], 'mixing': [3672, 3683, 3694, 3763], 'time)': [3673, 3684, 3695, 3764], 'measured': [3674, 3685, 3696], 'H': [3676], 'O;': [3677], '13C-edited': [3679, 3759], '(150': [3681, 3692], 'D2O;': [3687], 'two-dimensional': [3689], '1H-1H': [3690], 'peaks': [3700], 'picked': [3702], 'manually,': [3703], 'automated': [3711], 'assignment': [3713], 'CANDID': [3715], '(37Herrmann': [3716], 'Gu': [3718], '̈ntert': [3719], '319:': [3728], '209-227Crossref': [3729], '(1335)': [3732], 'several': [3737], 'rounds': [3738], 'calculation': [3741], 'manual': [3743], 'restraint': [3744, 3853, 3963], 'checking.': [3745], 'Dihedral': [3746, 3799], 'angle': [3747, 3768, 3839, 3904, 3962, 4015], '15N-1H': [3755], 'HNHB': [3756], 'NOESY-HSQC': [3760], '(50': [3761], 'spectra.': [3765], 'dihedral': [3767, 3903, 3961, 4014], 'backbone': [3775, 3978, 3984], 'shifts': [3777, 3809], 'TALOS': [3781], '(38Cornilescu': [3782], 'Delaglio': [3784], 'Bax': [3786], 'Biomol.': [3789], 'NMR.': [3790], '13:': [3792], '289-302Crossref': [3793], '(2740)': [3796], 'applied': [3802], 'good': [3804], 'fits': [3805], 'allowed': [3812], 'range': [3813], '±30°': [3815], '(for': [3816, 3819], 'φ),': [3817], '±40°': [3818], 'Ψ).': [3820], 'final': [3822], 'CNX': [3829], 'Accelrys).': [3832], '100': [3833], 'torsion': [3838], 'Cartesian': [3843], 'minimization.': [3846], 'lowest': [3852], 'violation': [3854], 'energy': [3855], 'chosen': [3857], 'represent': [3859], '(Table': [3863, 4379, 4505], 'S2).': [3864], 'One': [3865], 'ensemble': [3872], 'crystal': [3877, 3918], 'conformation': [3888, 3914, 3979, 4000], 'disulfide': [3892, 3909, 3951, 4005], '(Cys93/Cys104).': [3893], 'separate': [3896], 'set': [3897, 4279, 4287, 4308, 4356], 'force': [3907], 'bonds': [3910], 'adopt': [3912], '(-60': [3920], '±': [3921, 3926, 3932, 3981], '20°': [3922, 3927, 3933], 'χ1,': [3924], '-60°': [3925], 'χ2,': [3929], '-90': [3931], 'χ3)': [3935], 'addition': [3937], 'NMR-derived': [3940, 3993], 'restraints.': [3941], 'Using': [3942], 'these': [3943], 'had': [3946], 'desired': [3948], 'bond': [3952, 4006], 'geometry': [3953], 'yet': [3954], 'did': [3955], 'not': [3956], 'introduce': [3957], 'significant': [3958], 'violations': [3964], '(r.m.s.d.': [3965], '0.008': [3968], 'Å': [3969, 3983, 4277, 4285, 4317, 4365], '0.36°,': [3971], 'respectively)': [3972], 'noticeable': [3974], 'changes': [3975], '(0.58': [3980], '0.09': [3982], 'r.m.s.d.': [3985], '76–104': [3988], 'only).': [3995], 'Thus': [3996], 'difference': [3998], 'seen': [4001], 'Cys93/Cys104': [4004], 'result': [4008], 'lack': [4011], 'experimental': [4013], 'imprecise': [4019], 'nature': [4020], 'region.': [4027], 'Production': [4028], 'Crystallization': [4030], 'APRIL-Receptor': [4032], 'Complexes—A-PRIL': [4033], 'combined': [4088], 'buffer': [4090, 4101, 4150], 'A,': [4091, 4102, 4151], 'complex': [4095, 4136, 4165, 4436], 'concentrated': [4104, 4175], 'mg/ml.': [4107, 4178], 'Crystals': [4108, 4179], '19': [4111, 4182], 'sitting': [4114, 4185], 'drops': [4115, 4186], 'μl': [4118, 4123, 4189, 4194], 'reservoir': [4125, 4196], '(70%': [4127], 'methylpentane': [4128], 'diol,': [4129], 'm': [4131, 4199, 4231], 'Hepes,': [4132], '7.5).': [4134], 'first': [4142, 4222, 4599, 4622], 'Z-domain': [4153], 'endoproteinase': [4159], 'Lys-C': [4160], '(EMD': [4161], 'Biosciences),': [4162], 'repurified': [4167], '8.4': [4177], '(0.1': [4198], '5.0,': [4202, 4234], '5%': [4203, 4235], 'PEG': [4204, 4208, 4236, 4239, 4265], '8000,': [4205, 4237], '1000).': [4209], 'Crystallography—APRIL·TACI_d2': [4210], 'crystals': [4211, 4220], 'cryocooled': [4213], 'without': [4214], 'any': [4215], 'cryoprotectant.': [4217], 'transferred': [4223], 'artificial': [4226], 'mother': [4227, 4261], 'liquor': [4228, 4251, 4262], '1000,': [4240], '9.7.': [4249], 'Mother': [4250], 'slowly': [4253], 'exchanged': [4254], 'cryoprotectant': [4257], '20%': [4264], '300': [4266], 'cooled': [4269], 'immersion': [4271], 'nitrogen.': [4274], '1.9': [4276], '2.35': [4284], 'collected': [4291], '19BM': [4293], 'APS.': [4296], 'Processing': [4297], 'HKL': [4303, 4338], 'resulted': [4304, 4352], 'Rsym': [4310, 4358], '=': [4311, 4325, 4359, 4373], '8.6%': [4312], '(35%': [4313], '1.97–1.90': [4316], 'shell),': [4318, 4366], '99.6%': [4319], 'completeness,': [4320, 4368], '6.5-fold': [4321], 'redundancy,': [4322, 4370], '<I/σI>': [4324, 4372], '7.4': [4326], 'space': [4328, 4376], 'group': [4329, 4377], 'P212121,': [4330], 'whereas': [4331], 'processing': [4332], '(39Otwinowski': [4339], 'Z.': [4340], 'Minor': [4341], 'Methods': [4343], 'Enzymol.': [4344], '176:': [4346], '307-326Crossref': [4347], '(38619)': [4349], '6.7%': [4360], '(43%': [4361], '2.43–2.35': [4364], '99.9%': [4367], '9.4-fold': [4369], '11.7': [4374], 'P61': [4378], 'S4).': [4380, 4506], 'solved': [4384], 'molecular': [4386], 'replacement': [4387], 'AMoRe': [4391], '(PDB': [4398], 'code': [4399], '1U5Z': [4400], 'Scholar))': [4419], 'search': [4422, 4439], 'model': [4423, 4440], 'data,': [4427], 'refined': [4430], 'trimer': [4432], 'coordinates': [4433], 'data.': [4444], 'Refinement': [4445], 'performed': [4450], 'REFMAC5': [4454], '(40Project': [4455], 'Collaborative': [4456], 'Computational': [4457], 'Acta': [4458], 'Crystallogr.': [4459, 4463], 'Sect.': [4460], 'D': [4461], '1994;': [4464], '50:': [4465], '760-763Crossref': [4466], '(19797)': [4469], 'included': [4473], 'TLS': [4474], 'refinement': [4475], 'NCS': [4477], 'imposed': [4479], 'separately': [4480], 'receptor,': [4485], 'resulting': [4486], 'R/Rfree': [4489, 4498], '16.7/20.3%': [4491], '17.8/21.3%': [4500], '"ShortTACI":': [4507], 'An': [4508], 'Alternatively': [4509], 'Spliced': [4510], 'Form': [4511], 'Containing': [4514], 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