Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2116505693', 'doi': 'https://doi.org/10.1093/hmg/ddr306', 'title': 'Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways', 'display_name': 'Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways', 'publication_year': 2011, 'publication_date': '2011-07-13', 'ids': {'openalex': 'https://openalex.org/W2116505693', 'doi': 'https://doi.org/10.1093/hmg/ddr306', 'mag': '2116505693', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21752829'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddr306', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1093/hmg/ddr306', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003149780', 'display_name': 'Michela Palmieri', 'orcid': 'https://orcid.org/0000-0001-9373-1133'}, 'institutions': [{'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michela Palmieri', 'raw_affiliation_strings': ["Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,"], 'affiliations': [{'raw_affiliation_string': "Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,", 'institution_ids': ['https://openalex.org/I4210147586', 'https://openalex.org/I181547552', 'https://openalex.org/I4210117334']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088931288', 'display_name': 'Soren Impey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Soren Impey', 'raw_affiliation_strings': ['Oregon Stem Cell Center, Oregon Health and Sciences University, Portland, OR, USA,'], 'affiliations': [{'raw_affiliation_string': 'Oregon Stem Cell Center, Oregon Health and Sciences University, Portland, OR, USA,', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101581131', 'display_name': 'Hyojin Kang', 'orcid': 'https://orcid.org/0000-0002-3403-276X'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hyojin Kang', 'raw_affiliation_strings': ["Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,"], 'affiliations': [{'raw_affiliation_string': "Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,", 'institution_ids': ['https://openalex.org/I181547552', 'https://openalex.org/I4210117334', 'https://openalex.org/I4210147586']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008210618', 'display_name': 'Alberto di Ronza', 'orcid': 'https://orcid.org/0000-0002-9813-5143'}, 'institutions': [{'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alberto di Ronza', 'raw_affiliation_strings': ["Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,"], 'affiliations': [{'raw_affiliation_string': "Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,", 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586', 'https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032987207', 'display_name': 'Carl Pelz', 'orcid': 'https://orcid.org/0000-0002-2235-880X'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carl Pelz', 'raw_affiliation_strings': ['Oregon Stem Cell Center, Oregon Health and Sciences University, Portland, OR, USA,'], 'affiliations': [{'raw_affiliation_string': 'Oregon Stem Cell Center, Oregon Health and Sciences University, Portland, OR, USA,', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081495214', 'display_name': 'Marco Sardiello', 'orcid': 'https://orcid.org/0000-0001-6484-0250'}, 'institutions': [{'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Marco Sardiello', 'raw_affiliation_strings': ["Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,"], 'affiliations': [{'raw_affiliation_string': "Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,", 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586', 'https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077487765', 'display_name': 'Andrea Ballabio', 'orcid': 'https://orcid.org/0000-0003-1381-4604'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}, {'id': 'https://openalex.org/I4210117334', 'display_name': 'Neurological Research Institute', 'ror': 'https://ror.org/02ea83075', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210117334']}, {'id': 'https://openalex.org/I4210147586', 'display_name': "Texas Children's Hospital", 'ror': 'https://ror.org/05cz92x43', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147586']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}, {'id': 'https://openalex.org/I4210152213', 'display_name': 'Telethon Institute Of Genetics And Medicine', 'ror': 'https://ror.org/04xfdsg27', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210152213']}], 'countries': ['IT', 'US'], 'is_corresponding': True, 'raw_author_name': 'Andrea Ballabio', 'raw_affiliation_strings': ["Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,", 'Department of Pediatrics, Federico II University, Naples, Italy', 'Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy and'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Federico II University, Naples, Italy', 'institution_ids': ['https://openalex.org/I4210117450']}, {'raw_affiliation_string': "Department of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA,", 'institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586', 'https://openalex.org/I181547552']}, {'raw_affiliation_string': 'Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy and', 'institution_ids': ['https://openalex.org/I4210152213']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5081495214', 'https://openalex.org/A5077487765'], 'corresponding_institution_ids': ['https://openalex.org/I4210117334', 'https://openalex.org/I4210147586', 'https://openalex.org/I181547552', 'https://openalex.org/I4210117450', 'https://openalex.org/I4210117334', 'https://openalex.org/I4210147586', 'https://openalex.org/I181547552', 'https://openalex.org/I4210152213'], 'apc_list': {'value': 4181, 'currency': 'USD', 'value_usd': 4181, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.653, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 858, 'citation_normalized_percentile': {'value': 0.999878, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '20', 'issue': '19', 'first_page': '3852', 'last_page': '3866'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Calcium signaling and nucleotide metabolism', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tfeb', 'display_name': 'TFEB', 'score': 0.9744046}, {'id': 'https://openalex.org/keywords/proteostasis', 'display_name': 'Proteostasis', 'score': 0.4104761}], 'concepts': [{'id': 'https://openalex.org/C132647116', 'wikidata': 'https://www.wikidata.org/wiki/Q18032677', 'display_name': 'TFEB', 'level': 4, 'score': 0.9744046}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.85511047}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.6935471}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.68367386}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6537111}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5440866}, {'id': 'https://openalex.org/C28005876', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytosis', 'level': 3, 'score': 0.44770366}, {'id': 'https://openalex.org/C2781452922', 'wikidata': 'https://www.wikidata.org/wiki/Q2892805', 'display_name': 'Proteostasis', 'level': 2, 'score': 0.4104761}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23819369}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2259419}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.1913479}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19065171}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.11947438}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D051778', 'descriptor_name': 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053263', 'descriptor_name': 'Gene Regulatory Networks', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051778', 'descriptor_name': 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051778', 'descriptor_name': 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddr306', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21752829', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddr306', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.57}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 92, 'referenced_works': ['https://openalex.org/W1520187505', 'https://openalex.org/W1535022681', 'https://openalex.org/W18034176', 'https://openalex.org/W1966496217', 'https://openalex.org/W1967397444', 'https://openalex.org/W1968423702', 'https://openalex.org/W1972232405', 'https://openalex.org/W1975182596', 'https://openalex.org/W1975200363', 'https://openalex.org/W1977758513', 'https://openalex.org/W1979123940', 'https://openalex.org/W1983831622', 'https://openalex.org/W1985738984', 'https://openalex.org/W1987038381', 'https://openalex.org/W1989749381', 'https://openalex.org/W1989862537', 'https://openalex.org/W1990065094', 'https://openalex.org/W1991143933', 'https://openalex.org/W2000665911', 'https://openalex.org/W2003346910', 'https://openalex.org/W2009070900', 'https://openalex.org/W2014918593', 'https://openalex.org/W2018720126', 'https://openalex.org/W2025176940', 'https://openalex.org/W2027421433', 'https://openalex.org/W2029984090', 'https://openalex.org/W2033953495', 'https://openalex.org/W2034595398', 'https://openalex.org/W2035421116', 'https://openalex.org/W2035805790', 'https://openalex.org/W2039921716', 'https://openalex.org/W2041876692', 'https://openalex.org/W2050258803', 'https://openalex.org/W2051393367', 'https://openalex.org/W2053506736', 'https://openalex.org/W2055616662', 'https://openalex.org/W2056045773', 'https://openalex.org/W2057110063', 'https://openalex.org/W2058818863', 'https://openalex.org/W2065524119', 'https://openalex.org/W2072471477', 'https://openalex.org/W2072566861', 'https://openalex.org/W2077499130', 'https://openalex.org/W2081735322', 'https://openalex.org/W2082538104', 'https://openalex.org/W2083921257', 'https://openalex.org/W2085135498', 'https://openalex.org/W2089198803', 'https://openalex.org/W2092310066', 'https://openalex.org/W2092321143', 'https://openalex.org/W2093640897', 'https://openalex.org/W2098684174', 'https://openalex.org/W2104722369', 'https://openalex.org/W2106771547', 'https://openalex.org/W2108898978', 'https://openalex.org/W2111481682', 'https://openalex.org/W2111650918', 'https://openalex.org/W2113515610', 'https://openalex.org/W2114385219', 'https://openalex.org/W2115761267', 'https://openalex.org/W2123950558', 'https://openalex.org/W2124954099', 'https://openalex.org/W2124985265', 'https://openalex.org/W2125404510', 'https://openalex.org/W2126489732', 'https://openalex.org/W2128266248', 'https://openalex.org/W2132290516', 'https://openalex.org/W2135099287', 'https://openalex.org/W2136292095', 'https://openalex.org/W2136338518', 'https://openalex.org/W2140624072', 'https://openalex.org/W2141222038', 'https://openalex.org/W2148014281', 'https://openalex.org/W2149198894', 'https://openalex.org/W2149616074', 'https://openalex.org/W2150158059', 'https://openalex.org/W2150470627', 'https://openalex.org/W2153824991', 'https://openalex.org/W2154362705', 'https://openalex.org/W2156351032', 'https://openalex.org/W2156566257', 'https://openalex.org/W2157065169', 'https://openalex.org/W2157973824', 'https://openalex.org/W2158217645', 'https://openalex.org/W2158266834', 'https://openalex.org/W2158272128', 'https://openalex.org/W2158535498', 'https://openalex.org/W2160379721', 'https://openalex.org/W2164620224', 'https://openalex.org/W2169760054', 'https://openalex.org/W2171437346', 'https://openalex.org/W4230496537'], 'related_works': ['https://openalex.org/W4306971719', 'https://openalex.org/W4304091936', 'https://openalex.org/W4283330211', 'https://openalex.org/W4243180838', 'https://openalex.org/W4237382727', 'https://openalex.org/W3114379697', 'https://openalex.org/W3004905553', 'https://openalex.org/W2811264456', 'https://openalex.org/W2809738004', 'https://openalex.org/W2731930109'], 'abstract_inverted_index': {'In': [0], 'metazoans,': [1], 'lysosomes': [2], 'are': [3, 33, 183], 'the': [4, 7, 49, 116, 126, 136, 145, 153, 173, 187, 199], 'center': [5], 'for': [6, 205], 'degradation': [8, 137, 174], 'of': [9, 19, 30, 77, 83, 88, 94, 102, 115, 131, 138, 155, 175, 186, 221], 'macromolecules': [10], 'and': [11, 26, 39, 54, 58, 70, 98, 129, 142, 162, 165, 181], 'play': [12], 'a': [13, 17, 75, 122, 203, 219], 'key': [14], 'role': [15], 'in': [16, 152, 172, 218], 'variety': [18, 220], 'cellular': [20, 216], 'processes,': [21, 158], 'such': [22, 178], 'as': [23, 179, 202], 'autophagy,': [24, 160], 'exocytosis': [25], 'membrane': [27], 'repair.': [28], 'Defects': [29], 'lysosomal': [31, 36, 68, 132, 195], 'pathways': [32], 'associated': [34], 'with': [35, 40], 'storage': [37], 'disorders': [38], 'several': [41], 'late': [42], 'onset': [43], 'neurodegenerative': [44], 'diseases.': [45], 'We': [46], 'recently': [47], 'discovered': [48], 'CLEAR': [50, 117, 146, 188, 200], '(Coordinated': [51], 'Lysosomal': [52], 'Expression': [53], 'Regulation)': [55], 'gene': [56, 61], 'network': [57, 147, 201], 'its': [59], 'master': [60], 'transcription': [62], 'factor': [63], 'EB': [64], '(TFEB),': [65], 'which': [66], 'regulates': [67], 'biogenesis': [69], 'function.': [71], 'Here,': [72], 'we': [73, 191], 'used': [74], 'combination': [76], 'genomic': [78], 'approaches,': [79], 'including': [80, 159], 'ChIP-seq': [81], '(sequencing': [82], 'chromatin': [84], 'immunoprecipitate)': [85], 'analysis,': [86], 'profiling': [87], 'TFEB-mediated': [89], 'transcriptional': [90], 'induction,': [91], 'genome-wide': [92], 'mapping': [93], 'TFEB': [95, 103, 108], 'target': [96], 'sites': [97], 'recursive': [99], 'expression': [100], 'meta-analysis': [101], 'targets,': [104], 'to': [105, 149, 214], 'identify': [106], '471': [107], 'direct': [109], 'targets': [110, 213], 'that': [111, 134], 'represent': [112], 'essential': [113, 176], 'components': [114], 'network.': [118, 189], 'This': [119, 208], 'analysis': [120], 'revealed': [121], 'comprehensive': [123], 'system': [124], 'regulating': [125], 'expression,': [127], 'import': [128], 'activity': [130], 'enzymes': [133, 170], 'control': [135], 'proteins,': [139], 'glycosaminoglycans,': [140], 'sphingolipids': [141], 'glycogen.': [143], 'Interestingly,': [144], 'appears': [148], 'be': [150], 'involved': [151, 171], 'regulation': [154], 'additional': [156], 'lysosome-associated': [157], 'exo-': [161], 'endocytosis,': [163], 'phagocytosis': [164], 'immune': [166], 'response.': [167], 'Furthermore,': [168], 'non-lysosomal': [169], 'proteins': [177, 196], 'hemoglobin': [180], 'chitin': [182], 'also': [184], 'part': [185], 'Finally,': [190], 'identified': [192], 'nine': [193], 'novel': [194], 'by': [197], 'using': [198], 'tool': [204], 'prioritizing': [206], 'candidates.': [207], 'study': [209], 'provides': [210], 'potential': [211], 'therapeutic': [212], 'modulate': [215], 'clearance': [217], 'disease': [222], 'conditions.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2116505693', 'counts_by_year': [{'year': 2024, 'cited_by_count': 95}, {'year': 2023, 'cited_by_count': 102}, {'year': 2022, 'cited_by_count': 86}, {'year': 2021, 'cited_by_count': 124}, {'year': 2020, 'cited_by_count': 80}, {'year': 2019, 'cited_by_count': 71}, {'year': 2018, 'cited_by_count': 74}, {'year': 2017, 'cited_by_count': 58}, {'year': 2016, 'cited_by_count': 58}, {'year': 2015, 'cited_by_count': 33}, {'year': 2014, 'cited_by_count': 35}, {'year': 2013, 'cited_by_count': 24}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2025-01-11T18:16:42.510288', 'created_date': '2016-06-24'}