Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2116500923', 'doi': 'https://doi.org/10.1002/jcb.20886', 'title': 'Mesenchymal stem cells as trophic mediators', 'display_name': 'Mesenchymal stem cells as trophic mediators', 'publication_year': 2006, 'publication_date': '2006-04-17', 'ids': {'openalex': 'https://openalex.org/W2116500923', 'doi': 'https://doi.org/10.1002/jcb.20886', 'mag': '2116500923', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16619257'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.20886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086513199', 'display_name': 'Arnold I. Caplan', 'orcid': 'https://orcid.org/0000-0002-8677-6621'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arnold I. Caplan', 'raw_affiliation_strings': ['Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, MSC 118, Cleveland, Ohio 44106-7080'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, MSC 118, Cleveland, Ohio 44106-7080', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062673578', 'display_name': 'James E. Dennis', 'orcid': 'https://orcid.org/0000-0002-2006-7902'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James E. Dennis', 'raw_affiliation_strings': ['Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, MSC 118, Cleveland, Ohio 44106-7080'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, MSC 118, Cleveland, Ohio 44106-7080', 'institution_ids': ['https://openalex.org/I58956616']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 15.414, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2812, 'citation_normalized_percentile': {'value': 0.996727, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '98', 'issue': '5', 'first_page': '1076', 'last_page': '1084'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10176', 'display_name': 'Multipotent Mesenchymal Stem Cells', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10176', 'display_name': 'Multipotent Mesenchymal Stem Cells', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12264', 'display_name': 'Tissue Engineering and Regenerative Medicine', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mesenchymal-stem-cells', 'display_name': 'Mesenchymal Stem Cells', 'score': 0.559703}, {'id': 'https://openalex.org/keywords/stromal-cells', 'display_name': 'Stromal Cells', 'score': 0.524418}], 'concepts': [{'id': 'https://openalex.org/C198826908', 'wikidata': 'https://www.wikidata.org/wiki/Q1922379', 'display_name': 'Mesenchymal stem cell', 'level': 2, 'score': 0.8262072}, {'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.711545}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7009028}, {'id': 'https://openalex.org/C143441281', 'wikidata': 'https://www.wikidata.org/wiki/Q5133858', 'display_name': 'Clinical uses of mesenchymal stem cells', 'level': 5, 'score': 0.5882651}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.57347035}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.49651104}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.48579073}, {'id': 'https://openalex.org/C13685319', 'wikidata': 'https://www.wikidata.org/wiki/Q7607302', 'display_name': 'Stem cell transplantation for articular cartilage repair', 'level': 5, 'score': 0.48518378}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.46177495}, {'id': 'https://openalex.org/C171056886', 'wikidata': 'https://www.wikidata.org/wiki/Q193119', 'display_name': 'Regeneration (biology)', 'level': 2, 'score': 0.43735385}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.43073818}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.4118707}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38516283}, {'id': 'https://openalex.org/C20875687', 'wikidata': 'https://www.wikidata.org/wiki/Q2642600', 'display_name': 'Adult stem cell', 'level': 4, 'score': 0.33952752}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.32604235}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.28073728}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.11223158}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.08643213}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006410', 'descriptor_name': 'Hematopoiesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008592', 'descriptor_name': 'Menisci, Tibial', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008592', 'descriptor_name': 'Menisci, Tibial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D059630', 'descriptor_name': 'Mesenchymal Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.20886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16619257', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.68, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1631250427', 'https://openalex.org/W184818543', 'https://openalex.org/W1861117943', 'https://openalex.org/W1963852894', 'https://openalex.org/W1965484767', 'https://openalex.org/W1974864607', 'https://openalex.org/W1982426523', 'https://openalex.org/W1982561969', 'https://openalex.org/W1986300999', 'https://openalex.org/W1986457784', 'https://openalex.org/W1989560466', 'https://openalex.org/W1996682859', 'https://openalex.org/W2005848913', 'https://openalex.org/W2013542629', 'https://openalex.org/W2016662872', 'https://openalex.org/W2021293655', 'https://openalex.org/W2028036560', 'https://openalex.org/W2034452944', 'https://openalex.org/W2036452348', 'https://openalex.org/W2045820871', 'https://openalex.org/W2065427776', 'https://openalex.org/W2068135722', 'https://openalex.org/W2068380542', 'https://openalex.org/W2070435400', 'https://openalex.org/W2072386632', 'https://openalex.org/W2073420780', 'https://openalex.org/W2086793358', 'https://openalex.org/W2090041902', 'https://openalex.org/W2098234683', 'https://openalex.org/W2098734814', 'https://openalex.org/W2102824270', 'https://openalex.org/W2112619023', 'https://openalex.org/W2117412164', 'https://openalex.org/W2138732093', 'https://openalex.org/W2142226770', 'https://openalex.org/W2143022774', 'https://openalex.org/W2143677869', 'https://openalex.org/W2144268541', 'https://openalex.org/W2149790590', 'https://openalex.org/W2156393739', 'https://openalex.org/W2158048826', 'https://openalex.org/W2164260413', 'https://openalex.org/W2170811901', 'https://openalex.org/W2215584599', 'https://openalex.org/W2495267585', 'https://openalex.org/W2910567225', 'https://openalex.org/W4301481375'], 'related_works': ['https://openalex.org/W2889829380', 'https://openalex.org/W2802895030', 'https://openalex.org/W2351914518', 'https://openalex.org/W2143441328', 'https://openalex.org/W2036904838', 'https://openalex.org/W1986604564', 'https://openalex.org/W1985229106', 'https://openalex.org/W1980255205', 'https://openalex.org/W1979388177', 'https://openalex.org/W1184053576'], 'abstract_inverted_index': {'Abstract': [0], 'Adult': [1], 'marrow‐derived': [2], 'Mesenchymal': [3], 'Stem': [4], 'Cells': [5], '(MSCs)': [6], 'are': [7, 14, 87, 93, 124], 'capable': [8, 16], 'of': [9, 17, 21, 44, 78, 99, 110, 114, 129], 'dividing': [10], 'and': [11, 35, 46, 53, 69, 73, 76], 'their': [12], 'progeny': [13], 'further': [15], 'differentiating': [18], 'into': [19, 101], 'one': [20], 'several': [22], 'mesenchymal': [23], 'phenotypes': [24], 'such': [25], 'as': [26, 90], 'osteoblasts,': [27], 'chondrocytes,': [28], 'myocytes,': [29], 'marrow': [30], 'stromal': [31], 'cells,': [32], 'tendon‐ligament': [33], 'fibroblasts,': [34], 'adipocytes.': [36], 'In': [37], 'addition,': [38], 'these': [39], 'MSCs': [40, 100, 111], 'secrete': [41], 'a': [42], 'variety': [43], 'cytokines': [45], 'growth': [47], 'factors': [48, 59], 'that': [49], 'have': [50], 'both': [51], 'paracrine': [52], 'autocrine': [54], 'activities.': [55], 'These': [56, 84], 'secreted': [57], 'bioactive': [58], 'suppress': [60], 'the': [61, 96, 108, 127], 'local': [62], 'immune': [63], 'system,': [64], 'inhibit': [65], 'fibrosis': [66], '(scar': [67], 'formation)': [68], 'apoptosis,': [70], 'enhance': [71], 'angiogenesis,': [72], 'stimulate': [74], 'mitosis': [75], 'differentiation': [77, 98], 'tissue‐intrinsic': [79], 'reparative': [80], 'or': [81, 120], 'stem': [82], 'cells.': [83], 'effects,': [85, 92], 'which': [86, 106], 'referred': [88], 'to': [89], 'trophic': [91, 131], 'distinct': [94], 'from': [95], 'direct': [97], 'repair': [102], 'tissue.': [103], 'Several': [104], 'studies': [105], 'tested': [107], 'use': [109], 'in': [112, 133], 'models': [113, 123], 'infarct': [115], '(injured': [116], 'heart),': [117], 'stroke': [118], '(brain),': [119], 'meniscus': [121], 'regeneration': [122], 'reviewed': [125], 'within': [126], 'context': [128], 'MSC‐mediated': [130], 'effects': [132], 'tissue': [134], 'repair.': [135], 'J.': [136], 'Cell.': [137], 'Biochem.': [138], '98:': [139], '1076–1084,': [140], '2006.': [141], '©': [142], '2006': [143], 'Wiley‐Liss,': [144], 'Inc.': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2116500923', 'counts_by_year': [{'year': 2024, 'cited_by_count': 61}, {'year': 2023, 'cited_by_count': 104}, {'year': 2022, 'cited_by_count': 132}, {'year': 2021, 'cited_by_count': 185}, {'year': 2020, 'cited_by_count': 203}, {'year': 2019, 'cited_by_count': 177}, {'year': 2018, 'cited_by_count': 176}, {'year': 2017, 'cited_by_count': 200}, {'year': 2016, 'cited_by_count': 202}, {'year': 2015, 'cited_by_count': 224}, {'year': 2014, 'cited_by_count': 195}, {'year': 2013, 'cited_by_count': 217}, {'year': 2012, 'cited_by_count': 193}], 'updated_date': '2024-09-13T23:30:35.288962', 'created_date': '2016-06-24'}