Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2116431837', 'doi': 'https://doi.org/10.1084/jem.20110921', 'title': 'Analysis of the chronic lymphocytic leukemia coding genome: role of <i>NOTCH1</i> mutational activation', 'display_name': 'Analysis of the chronic lymphocytic leukemia coding genome: role of <i>NOTCH1</i> mutational activation', 'publication_year': 2011, 'publication_date': '2011-06-13', 'ids': {'openalex': 'https://openalex.org/W2116431837', 'doi': 'https://doi.org/10.1084/jem.20110921', 'mag': '2116431837', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21670202', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3135373'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.20110921', 'pdf_url': 'http://jem.rupress.org/content/jem/208/7/1389.full.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://jem.rupress.org/content/jem/208/7/1389.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016948495', 'display_name': 'Giulia Fabbri', 'orcid': 'https://orcid.org/0000-0001-7690-8021'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I4210145812', 'display_name': 'Cancer Genetics (United States)', 'ror': 'https://ror.org/05feyya22', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145812']}, {'id': 'https://openalex.org/I4390039230', 'display_name': 'Herbert Irving Comprehensive Cancer Center', 'ror': 'https://ror.org/051kc1939', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039230']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Giulia Fabbri', 'raw_affiliation_strings': ['Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I4210145812', 'https://openalex.org/I4390039230']}, {'raw_affiliation_string': 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015659332', 'display_name': 'Silvia Rasi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Rasi', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015790909', 'display_name': 'Davide Rossi', 'orcid': 'https://orcid.org/0000-0002-2837-1597'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Davide Rossi', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101464596', 'display_name': 'Владимир Трифонов', 'orcid': 'https://orcid.org/0000-0002-1810-1825'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I4210145812', 'display_name': 'Cancer Genetics (United States)', 'ror': 'https://ror.org/05feyya22', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145812']}, {'id': 'https://openalex.org/I4390039230', 'display_name': 'Herbert Irving Comprehensive Cancer Center', 'ror': 'https://ror.org/051kc1939', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039230']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vladimir Trifonov', 'raw_affiliation_strings': ['Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I4210145812', 'https://openalex.org/I4390039230']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017811469', 'display_name': 'Hossein Khiabanian', 'orcid': 'https://orcid.org/0000-0003-1446-4394'}, 'institutions': [{'id': 'https://openalex.org/I4390039230', 'display_name': 'Herbert Irving Comprehensive Cancer Center', 'ror': 'https://ror.org/051kc1939', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039230']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I4210145812', 'display_name': 'Cancer Genetics (United States)', 'ror': 'https://ror.org/05feyya22', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145812']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hossein Khiabanian', 'raw_affiliation_strings': ['Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4'], 'affiliations': [{'raw_affiliation_string': 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I4390039230', 'https://openalex.org/I4210145812']}, {'raw_affiliation_string': 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002881888', 'display_name': 'Jing Ma', 'orcid': 'https://orcid.org/0000-0001-8925-7686'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Ma', 'raw_affiliation_strings': ['Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105 6'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105 6', 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023203532', 'display_name': 'Adina Grunn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145812', 'display_name': 'Cancer Genetics (United States)', 'ror': 'https://ror.org/05feyya22', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145812']}, {'id': 'https://openalex.org/I4390039230', 'display_name': 'Herbert Irving Comprehensive Cancer Center', 'ror': 'https://ror.org/051kc1939', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039230']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adina Grunn', 'raw_affiliation_strings': ['Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4'], 'affiliations': [{'raw_affiliation_string': 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I4210145812', 'https://openalex.org/I4390039230']}, {'raw_affiliation_string': 'Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007409312', 'display_name': 'Marco Fangazio', 'orcid': 'https://orcid.org/0000-0001-5414-6134'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Fangazio', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031664151', 'display_name': 'Daniela Capello', 'orcid': 'https://orcid.org/0000-0001-9157-8753'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniela Capello', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076089771', 'display_name': 'Sara Monti', 'orcid': 'https://orcid.org/0000-0002-1800-6772'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sara Monti', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103693074', 'display_name': 'Stefania Cresta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefania Cresta', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069026427', 'display_name': 'Ernesto Gargiulo', 'orcid': 'https://orcid.org/0000-0002-4485-4599'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ernesto Gargiulo', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078295579', 'display_name': 'Francesco Forconi', 'orcid': 'https://orcid.org/0000-0002-2211-1831'}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Forconi', 'raw_affiliation_strings': ['Division of Hematology, University of Siena, 53100 Siena, Italy 7'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, University of Siena, 53100 Siena, Italy 7', 'institution_ids': ['https://openalex.org/I102064193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101725875', 'display_name': 'Anna Guarini', 'orcid': 'https://orcid.org/0000-0002-9594-7330'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Guarini', 'raw_affiliation_strings': ['Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, 00161 Rome, Italy 8'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, 00161 Rome, Italy 8', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019034145', 'display_name': 'Luca Arcaini', 'orcid': 'https://orcid.org/0000-0002-9504-991X'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luca Arcaini', 'raw_affiliation_strings': ['Division of Hematology, Department of Hematology Oncology, University of Pavia Medical School, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy 9'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Hematology Oncology, University of Pavia Medical School, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy 9', 'institution_ids': ['https://openalex.org/I25217355', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013643615', 'display_name': 'Marco Paulli', 'orcid': 'https://orcid.org/0000-0003-2454-5980'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Paulli', 'raw_affiliation_strings': ['Institute of Pathology, University of Pavia, 27100 Pavia, Italy 10'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, University of Pavia, 27100 Pavia, Italy 10', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030806032', 'display_name': 'Luca Laurenti', 'orcid': 'https://orcid.org/0000-0002-8327-1396'}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luca Laurenti', 'raw_affiliation_strings': ['Institute of Hematology 11 and 12', 'Institute of Pathology, Catholic University of the Sacred Heart, 00618 Rome, Italy 11 and 12'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology 11 and 12', 'institution_ids': []}, {'raw_affiliation_string': 'Institute of Pathology, Catholic University of the Sacred Heart, 00618 Rome, Italy 11 and 12', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018323809', 'display_name': 'Luigi Maria Larocca', 'orcid': 'https://orcid.org/0000-0003-1739-4758'}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luigi M. Larocca', 'raw_affiliation_strings': ['Institute of Hematology 11 and 12', 'Institute of Pathology, Catholic University of the Sacred Heart, 00618 Rome, Italy 11 and 12'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology 11 and 12', 'institution_ids': []}, {'raw_affiliation_string': 'Institute of Pathology, Catholic University of the Sacred Heart, 00618 Rome, Italy 11 and 12', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080861890', 'display_name': 'Roberto Marasca', 'orcid': 'https://orcid.org/0000-0002-6431-6878'}, 'institutions': [{'id': 'https://openalex.org/I122346577', 'display_name': 'University of Modena and Reggio Emilia', 'ror': 'https://ror.org/02d4c4y02', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I122346577']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Roberto Marasca', 'raw_affiliation_strings': ['Division of Hematology, Department of Oncology and Hematology, University of Modena and Reggio Emilia, 41124 Modena, Italy 13'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Oncology and Hematology, University of Modena and Reggio Emilia, 41124 Modena, Italy 13', 'institution_ids': ['https://openalex.org/I122346577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073179633', 'display_name': 'Valter Gattei', 'orcid': 'https://orcid.org/0000-0001-5933-9680'}, 'institutions': [{'id': 'https://openalex.org/I4210128630', 'display_name': 'Centro di Riferimento Oncologico', 'ror': 'https://ror.org/03ks1vk59', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128630', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valter Gattei', 'raw_affiliation_strings': ['Clinical and Experimental Onco-Hematology, Centro di Riferimento Ocologico, Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy 14'], 'affiliations': [{'raw_affiliation_string': 'Clinical and Experimental Onco-Hematology, Centro di Riferimento Ocologico, Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy 14', 'institution_ids': ['https://openalex.org/I4210128630']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110206675', 'display_name': 'David Oscier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799967250', 'display_name': 'Royal Bournemouth Hospital', 'ror': 'https://ror.org/01v14jr37', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799967250', 'https://openalex.org/I4387155041']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Oscier', 'raw_affiliation_strings': ['Department of Hematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK 15'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK 15', 'institution_ids': ['https://openalex.org/I2799967250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066518317', 'display_name': 'Francesco Bertoni', 'orcid': 'https://orcid.org/0000-0001-5637-8983'}, 'institutions': [{'id': 'https://openalex.org/I4210101830', 'display_name': 'Institute of Oncology Research', 'ror': 'https://ror.org/01dpyn972', 'country_code': 'CH', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101830', 'https://openalex.org/I57201433']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Francesco Bertoni', 'raw_affiliation_strings': ['Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland 16'], 'affiliations': [{'raw_affiliation_string': 'Oncology Institute of Southern Switzerland, CH-6500 Bellinzona, Switzerland 16', 'institution_ids': ['https://openalex.org/I4210101830']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048744038', 'display_name': 'Charles G. Mullighan', 'orcid': 'https://orcid.org/0000-0002-1871-1850'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles G. Mullighan', 'raw_affiliation_strings': ['Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105 6'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105 6', 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009431453', 'display_name': 'Robin Foà', 'orcid': 'https://orcid.org/0000-0002-5021-3026'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Robin Foá', 'raw_affiliation_strings': ['Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, 00161 Rome, Italy 8'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, 00161 Rome, Italy 8', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014297834', 'display_name': 'Laura Pasqualucci', 'orcid': 'https://orcid.org/0000-0001-6819-7370'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I4210145812', 'display_name': 'Cancer Genetics (United States)', 'ror': 'https://ror.org/05feyya22', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145812']}, {'id': 'https://openalex.org/I4390039230', 'display_name': 'Herbert Irving Comprehensive Cancer Center', 'ror': 'https://ror.org/051kc1939', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039230']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura Pasqualucci', 'raw_affiliation_strings': ['Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I4210145812', 'https://openalex.org/I4210145812', 'https://openalex.org/I4390039230', 'https://openalex.org/I4390039230']}, {'raw_affiliation_string': 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056128255', 'display_name': 'Raúl Rabadán', 'orcid': 'https://orcid.org/0000-0001-7946-9255'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I4210145812', 'display_name': 'Cancer Genetics (United States)', 'ror': 'https://ror.org/05feyya22', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145812']}, {'id': 'https://openalex.org/I4390039230', 'display_name': 'Herbert Irving Comprehensive Cancer Center', 'ror': 'https://ror.org/051kc1939', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4390039230']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raul Rabadan', 'raw_affiliation_strings': ['Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Development, Columbia University, New York, NY 10032 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center 1 , 2 , 3 , and 4', 'institution_ids': ['https://openalex.org/I4210145812', 'https://openalex.org/I4390039230']}, {'raw_affiliation_string': 'Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics 1 , 2 , 3 , and 4', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pathology and Cell Biology 1 , 2 , 3 , and 4', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012955086', 'display_name': 'Riccardo Dalla‐Favera', 'orcid': 'https://orcid.org/0000-0002-3502-8826'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Riccardo Dalla-Favera', 'raw_affiliation_strings': ['Columbia University'], 'affiliations': [{'raw_affiliation_string': 'Columbia University', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041745367', 'display_name': 'Gianluca Gaïdano', 'orcid': 'https://orcid.org/0000-0002-4681-0151'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianluca Gaidano', 'raw_affiliation_strings': ['Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'Universita del Piemonte Orientale'], 'affiliations': [{'raw_affiliation_string': 'Universita del Piemonte Orientale', 'institution_ids': ['https://openalex.org/I123338534']}, {'raw_affiliation_string': 'Division of Hematology, Department of Clinical and Experimental Medicine and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy 5', 'institution_ids': ['https://openalex.org/I123338534']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 14, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 41.003, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 595, 'citation_normalized_percentile': {'value': 0.999823, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '208', 'issue': '7', 'first_page': '1389', 'last_page': '1401'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Immunodeficiency and Autoimmune Disorders', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777938653', 'wikidata': 'https://www.wikidata.org/wiki/Q1088156', 'display_name': 'Chronic lymphocytic leukemia', 'level': 3, 'score': 0.8439419}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.57996786}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5793848}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5439901}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.47048974}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.46476305}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.36813834}], 'mesh': [{'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018628', 'descriptor_name': 'Gene Dosage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050438', 'descriptor_name': 'Genes, Immunoglobulin Heavy Chain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051881', 'descriptor_name': 'Receptor, Notch1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017211', 'descriptor_name': 'Treatment Failure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.20110921', 'pdf_url': 'http://jem.rupress.org/content/jem/208/7/1389.full.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3135373', 'pdf_url': 'https://europepmc.org/articles/pmc3135373?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11380/695067', 'pdf_url': 'https://iris.unimore.it/bitstream/11380/695067/1/Fabbri_JEM_2011%20%28Notch1%20mutations%29.pdf', 'source': {'id': 'https://openalex.org/S4306400718', 'display_name': 'IRIS UNIMORE (University of Modena and Reggio Emilia)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I122346577', 'host_organization_name': 'University of Modena and Reggio Emilia', 'host_organization_lineage': ['https://openalex.org/I122346577'], 'host_organization_lineage_names': ['University of Modena and Reggio Emilia'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135373', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21670202', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.20110921', 'pdf_url': 'http://jem.rupress.org/content/jem/208/7/1389.full.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'No poverty', 'score': 0.71, 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1243376384', 'https://openalex.org/W1429374962', 'https://openalex.org/W1605230984', 'https://openalex.org/W1838957180', 'https://openalex.org/W1963687548', 'https://openalex.org/W1964480169', 'https://openalex.org/W1973562447', 'https://openalex.org/W1982023788', 'https://openalex.org/W1983491627', 'https://openalex.org/W1984065010', 'https://openalex.org/W1989773675', 'https://openalex.org/W1993262772', 'https://openalex.org/W1993986769', 'https://openalex.org/W1994711799', 'https://openalex.org/W2000589976', 'https://openalex.org/W2010855093', 'https://openalex.org/W2013834476', 'https://openalex.org/W2014119870', 'https://openalex.org/W2020045401', 'https://openalex.org/W2020069805', 'https://openalex.org/W2022054497', 'https://openalex.org/W2023568503', 'https://openalex.org/W2028330103', 'https://openalex.org/W2030105242', 'https://openalex.org/W2035413537', 'https://openalex.org/W2035918677', 'https://openalex.org/W2037290810', 'https://openalex.org/W2041175983', 'https://openalex.org/W2041675180', 'https://openalex.org/W2044352858', 'https://openalex.org/W2047259755', 'https://openalex.org/W2054051862', 'https://openalex.org/W2059145105', 'https://openalex.org/W2060710804', 'https://openalex.org/W2063627118', 'https://openalex.org/W2064519910', 'https://openalex.org/W2066663722', 'https://openalex.org/W2097938836', 'https://openalex.org/W2101035019', 'https://openalex.org/W2103441770', 'https://openalex.org/W2108258898', 'https://openalex.org/W2113503593', 'https://openalex.org/W2113895281', 'https://openalex.org/W2116382435', 'https://openalex.org/W2116860515', 'https://openalex.org/W2116965161', 'https://openalex.org/W2129961058', 'https://openalex.org/W2133545780', 'https://openalex.org/W2134061682', 'https://openalex.org/W2135314242', 'https://openalex.org/W2135763107', 'https://openalex.org/W2138155367', 'https://openalex.org/W2139216037', 'https://openalex.org/W2142099365', 'https://openalex.org/W2143686181', 'https://openalex.org/W2144064491', 'https://openalex.org/W2144924266', 'https://openalex.org/W2150608281', 'https://openalex.org/W2150677022', 'https://openalex.org/W2153010521', 'https://openalex.org/W2159833518', 'https://openalex.org/W2164021955', 'https://openalex.org/W2164261107', 'https://openalex.org/W2168156874', 'https://openalex.org/W2318933236', 'https://openalex.org/W2503110302', 'https://openalex.org/W2610048824', 'https://openalex.org/W4247053599', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W88401132', 'https://openalex.org/W579273576', 'https://openalex.org/W4386544784', 'https://openalex.org/W4386277455', 'https://openalex.org/W3014999046', 'https://openalex.org/W2987420353', 'https://openalex.org/W2486297723', 'https://openalex.org/W2418031697', 'https://openalex.org/W2076631739', 'https://openalex.org/W1491897707'], 'abstract_inverted_index': {'The': [0, 17], 'pathogenesis': [1], 'of': [2, 20, 36, 82, 95, 111, 116, 144, 151, 164, 175, 185], 'chronic': [3], 'lymphocytic': [4], 'leukemia': [5, 10], '(CLL),': [6], 'the': [7, 27, 32, 56, 80, 142, 152, 173, 176], 'most': [8, 94], 'common': [9], 'in': [11, 26, 91, 103, 114, 136], 'adults,': [12], 'is': [13], 'still': [14], 'largely': [15], 'unknown.': [16], 'full': [18], 'spectrum': [19], 'genetic': [21], 'lesions': [22], 'that': [23, 55], 'are': [24], 'present': [25], 'CLL': [28, 58, 106, 117, 138, 157, 177], 'genome,': [29], 'and': [30, 34, 48, 71, 180, 187], 'therefore': [31], 'number': [33, 50, 74], 'identity': [35], 'dysregulated': [37, 183], 'cellular': [38], 'pathways,': [39], 'have': [40], 'not': [41, 85], 'been': [42], 'identified.': [43], 'By': [44], 'combining': [45], 'next-generation': [46], 'sequencing': [47], 'copy': [49, 73], 'analysis,': [51], 'we': [52], 'show': [53], 'here': [54], 'typical': [57], 'coding': [59, 178], 'genome': [60, 179], 'contains': [61], '&lt;20': [62], 'clonally': [63], 'represented': [64], 'gene': [65], 'alterations/case,': [66], 'including': [67], 'predominantly': [68], 'nonsilent': [69], 'mutations,': [70], 'fewer': [72], 'aberrations.': [75], 'These': [76, 167], 'analyses': [77], 'led': [78], 'to': [79, 88], 'discovery': [81], 'several': [83], 'genes': [84, 97], 'previously': [86], 'known': [87], 'be': [89], 'altered': [90], 'CLL.': [92], 'Although': [93], 'these': [96], 'were': [98], 'affected': [99], 'at': [100, 118, 122, 156], 'low': [101], 'frequency': [102, 125], 'an': [104, 161], 'expanded': [105], 'screening': [107], 'cohort,': [108], 'mutational': [109], 'activation': [110, 155], 'NOTCH1,': [112], 'observed': [113], '8.3%': [115], 'diagnosis,': [119], 'was': [120], 'detected': [121], 'significantly': [123], 'higher': [124], 'during': [126], 'disease': [127], 'progression': [128], 'toward': [129], 'Richter': [130], 'transformation': [131], '(31.0%),': [132], 'as': [133, 135, 160], 'well': [134], 'chemorefractory': [137], '(20.8%).': [139], 'Consistent': [140], 'with': [141, 147], 'association': [143], 'NOTCH1': [145, 154], 'mutations': [146], 'clinically': [148], 'aggressive': [149], 'forms': [150], 'disease,': [153], 'diagnosis': [158], 'emerged': [159], 'independent': [162], 'predictor': [163], 'poor': [165], 'survival.': [166], 'results': [168], 'provide': [169], 'initial': [170], 'data': [171], 'on': [172], 'complexity': [174], 'identify': [181], 'a': [182], 'pathway': [184], 'diagnostic': [186], 'therapeutic': [188], 'relevance.': [189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2116431837', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 21}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 28}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 51}, {'year': 2017, 'cited_by_count': 43}, {'year': 2016, 'cited_by_count': 51}, {'year': 2015, 'cited_by_count': 48}, {'year': 2014, 'cited_by_count': 63}, {'year': 2013, 'cited_by_count': 89}, {'year': 2012, 'cited_by_count': 83}], 'updated_date': '2025-01-12T19:41:01.258476', 'created_date': '2016-06-24'}