Publication Information

{'id': 'https://openalex.org/W2116419063', 'doi': 'https://doi.org/10.1159/000069313', 'title': 'A Pilot Phase II Study of Capecitabine in Advanced or Recurrent Gastric Cancer', 'display_name': 'A Pilot Phase II Study of Capecitabine in Advanced or Recurrent Gastric Cancer', 'publication_year': 2003, 'publication_date': '2003-01-01', 'ids': {'openalex': 'https://openalex.org/W2116419063', 'doi': 'https://doi.org/10.1159/000069313', 'mag': '2116419063', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12697963'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1159/000069313', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S198727964', 'display_name': 'Oncology', 'issn_l': '0030-2414', 'issn': ['0030-2414', '1423-0232'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068425977', 'display_name': 'Wasaburo Koizumi', 'orcid': 'https://orcid.org/0000-0001-9972-1083'}, 'institutions': [{'id': 'https://openalex.org/I4210111955', 'display_name': 'Kitasato University Hospital', 'ror': 'https://ror.org/02b3e2815', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111955']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Wasaburo Koizumi', 'raw_affiliation_strings': ['Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Kanagawa,'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Kanagawa,', 'institution_ids': ['https://openalex.org/I4210111955']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108472312', 'display_name': 'Katsunori Saigenji', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210111955', 'display_name': 'Kitasato University Hospital', 'ror': 'https://ror.org/02b3e2815', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111955']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Katsunori Saigenji', 'raw_affiliation_strings': ['Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Kanagawa,'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, East Hospital, Kitasato University School of Medicine, Kanagawa,', 'institution_ids': ['https://openalex.org/I4210111955']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109897774', 'display_name': 'S Ujiie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107389', 'display_name': 'Miyagi Prefectural Hospital Organization', 'ror': 'https://ror.org/01qt7mp11', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107389']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shigeki Ujiie', 'raw_affiliation_strings': ['Department of Drug Therapy, Miyagi Prefectural Cancer Center, Miyagi,'], 'affiliations': [{'raw_affiliation_string': 'Department of Drug Therapy, Miyagi Prefectural Cancer Center, Miyagi,', 'institution_ids': ['https://openalex.org/I4210107389']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026555298', 'display_name': 'Masanori Terashima', 'orcid': 'https://orcid.org/0000-0002-2967-8267'}, 'institutions': [{'id': 'https://openalex.org/I180680657', 'display_name': 'Iwate Medical University', 'ror': 'https://ror.org/04cybtr86', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I180680657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masanori Terashima', 'raw_affiliation_strings': ['First Department of Surgery, Iwate Medical University School of Medicine, Iwate,'], 'affiliations': [{'raw_affiliation_string': 'First Department of Surgery, Iwate Medical University School of Medicine, Iwate,', 'institution_ids': ['https://openalex.org/I180680657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110724607', 'display_name': 'Yu Sakata', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090794', 'display_name': 'Aomori Prefectural Central Hospital', 'ror': 'https://ror.org/00bq8v746', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210090794']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yu Sakata', 'raw_affiliation_strings': ['Department of Gastroenterology, Aomori Prefectural Central Hospital, Aomori, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Aomori Prefectural Central Hospital, Aomori, and', 'institution_ids': ['https://openalex.org/I4210090794']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112141513', 'display_name': 'T Taguchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140891', 'display_name': 'Japan Society of Chemotherapy', 'ror': 'https://ror.org/040vema78', 'country_code': 'JP', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210140891']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuo Taguchi', 'raw_affiliation_strings': ['Japan Society for Cancer Chemotherapy, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Japan Society for Cancer Chemotherapy, Osaka, Japan', 'institution_ids': ['https://openalex.org/I4210140891']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.542, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 85, 'citation_normalized_percentile': {'value': 0.904133, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '64', 'issue': '3', 'first_page': '232', 'last_page': '236'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10696', 'display_name': 'Gastric Cancer Management and Outcomes', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10696', 'display_name': 'Gastric Cancer Management and Outcomes', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777909004', 'wikidata': 'https://www.wikidata.org/wiki/Q420207', 'display_name': 'Capecitabine', 'level': 4, 'score': 0.9195216}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.7013446}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6313346}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5265513}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4719495}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.20357981}], 'mesh': [{'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009364', 'descriptor_name': 'Neoplasm Recurrence, Local', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069287', 'descriptor_name': 'Capecitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009364', 'descriptor_name': 'Neoplasm Recurrence, Local', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010865', 'descriptor_name': 'Pilot Projects', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1159/000069313', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S198727964', 'display_name': 'Oncology', 'issn_l': '0030-2414', 'issn': ['0030-2414', '1423-0232'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310317820', 'host_organization_name': 'Karger Publishers', 'host_organization_lineage': ['https://openalex.org/P4310317820'], 'host_organization_lineage_names': ['Karger Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12697963', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W121414984', 'https://openalex.org/W1571748472', 'https://openalex.org/W1773171357', 'https://openalex.org/W1847455118', 'https://openalex.org/W1849818006', 'https://openalex.org/W1876804437', 'https://openalex.org/W1888050314', 'https://openalex.org/W1905936368', 'https://openalex.org/W1910716144', 'https://openalex.org/W1919810009', 'https://openalex.org/W1939003096', 'https://openalex.org/W1941365207', 'https://openalex.org/W1966574632', 'https://openalex.org/W1970876591', 'https://openalex.org/W1974734959', 'https://openalex.org/W1974775657', 'https://openalex.org/W1980253503', 'https://openalex.org/W1984254136', 'https://openalex.org/W1986952772', 'https://openalex.org/W2008575122', 'https://openalex.org/W2018619890', 'https://openalex.org/W2026255963', 'https://openalex.org/W2039310969', 'https://openalex.org/W2044970916', 'https://openalex.org/W2055977724', 'https://openalex.org/W2058029442', 'https://openalex.org/W2077637101', 'https://openalex.org/W2085328261', 'https://openalex.org/W2095181507', 'https://openalex.org/W2098627619', 'https://openalex.org/W2099658604', 'https://openalex.org/W2123732467', 'https://openalex.org/W2128447158', 'https://openalex.org/W2131770017', 'https://openalex.org/W2137194656', 'https://openalex.org/W2138577761', 'https://openalex.org/W2138926750', 'https://openalex.org/W2140626944', 'https://openalex.org/W2155421004', 'https://openalex.org/W2171343672', 'https://openalex.org/W2227311140', 'https://openalex.org/W2314927739', 'https://openalex.org/W2473787171', 'https://openalex.org/W2499418920', 'https://openalex.org/W2602544133', 'https://openalex.org/W2612574275'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3144346200', 'https://openalex.org/W3109960249', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W192535437'], 'abstract_inverted_index': {'To': [0], 'evaluate': [1], 'the': [2, 66, 101, 110, 168], 'efficacy': [3], 'and': [4, 109, 134, 147, 165], 'safety': [5], 'of': [6, 46, 96, 119, 141, 155, 170, 180], 'capecitabine': [7, 34, 71, 181], 'in': [8, 23, 65, 74, 126, 167], 'patients': [9, 62, 128], 'with': [10, 25], 'advanced': [11, 26, 171], 'or': [12, 27, 50, 122, 158, 172], 'recurrent': [13, 28, 173], 'gastric': [14, 29, 174], 'cancer,': [15], 'we': [16], 'conducted': [17], 'a': [18, 183], 'pilot': [19], 'phase': [20, 177], 'II': [21, 178], 'study': [22], 'Japan.Patients': [24], 'cancer': [30], 'were': [31, 53, 63, 124], 'given': [32], 'oral': [33], '828': [35], 'mg/m(2)': [36], 'twice': [37], 'daily': [38], 'for': [39], '3': [40, 121, 157], 'weeks,': [41], 'followed': [42], 'by': [43], '1': [44, 78, 135], 'week': [45], 'no': [47], 'treatment.': [48], 'Two': [49], 'more': [51], 'cycles': [52], 'administered.': [54], 'From': [55], 'July': [56], '1996': [57], 'to': [58, 70, 80, 104, 162], 'December': [59], '1997,': [60], '32': [61], 'enrolled': [64], 'study.': [67], 'The': [68, 93], 'response': [69, 84, 97], 'was': [72, 86, 98, 160], 'evaluated': [73], '31': [75], 'patients,': [76], 'excluding': [77], 'found': [79], 'be': [81, 163], 'ineligible.The': [82], 'overall': [83], 'rate': [85], '19.4%': [87], '(6/31,': [88], '95%': [89], 'confidence': [90], 'interval:': [91], '7.5-37.5%).': [92], 'median': [94, 102, 111], 'duration': [95], '124.5': [99], 'days,': [100, 108], 'time': [103, 113], 'disease': [105], 'progression': [106], '85.0': [107], 'survival': [112], '247.5': [114], 'days.': [115], 'Drug-related': [116], 'adverse': [117], 'events': [118], 'grade': [120, 156], 'higher': [123], 'infrequent:': [125], '2': [127], '(6.3%)': [129], 'total': [130], 'bilirubin': [131], 'concentration': [132], 'increased,': [133], 'patient': [136, 151], '(3.1%)': [137], 'each': [138], 'had': [139, 152], 'elevation': [140], 'GOT,': [142], 'anemia,': [143], 'lymphopenia,': [144], 'increased': [145], 'creatinine,': [146], 'hand-foot': [148], 'syndrome.': [149], 'No': [150], 'gastrointestinal': [153], 'toxicity': [154], 'higher.Capecitabine': [159], 'suggested': [161], 'safe': [164], 'effective': [166], 'treatment': [169], 'cancer.': [175], 'Further': [176], 'studies': [179], 'on': [182], 'large': [184], 'scale': [185], 'are': [186], 'warranted.': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2116419063', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T14:45:53.477835', 'created_date': '2016-06-24'}